Alignment of the gene Family HBG080254 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN KVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRF Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE KVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRF A2AFQ0_MOUSE A2AFQ0_MOUSE KVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRF Q4JG03_MOUSE Q4JG03_MOUSE KVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRF HUWE1_MOUSE HUWE1_MOUSE KVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRF MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN DGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTT Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE DGILADAGQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTT A2AFQ0_MOUSE A2AFQ0_MOUSE DGILADAGQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTT Q4JG03_MOUSE Q4JG03_MOUSE DGILADAGQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTT HUWE1_MOUSE HUWE1_MOUSE DGILADAGQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTT MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN LLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAE Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE LLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAE A2AFQ0_MOUSE A2AFQ0_MOUSE LLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAE Q4JG03_MOUSE Q4JG03_MOUSE LLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAE HUWE1_MOUSE HUWE1_MOUSE LLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAE MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN CCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIME Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE CCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIME A2AFQ0_MOUSE A2AFQ0_MOUSE CCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIME Q4JG03_MOUSE Q4JG03_MOUSE CCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIME HUWE1_MOUSE HUWE1_MOUSE CCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIME MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN SLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSIL Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE SLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSIL A2AFQ0_MOUSE A2AFQ0_MOUSE SLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSIL Q4JG03_MOUSE Q4JG03_MOUSE SLTKMYSIPKDRQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSIL HUWE1_MOUSE HUWE1_MOUSE SLTKMYSIPKDRQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSIL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN YNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPV Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE YNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPV A2AFQ0_MOUSE A2AFQ0_MOUSE YNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPV Q4JG03_MOUSE Q4JG03_MOUSE YNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPV HUWE1_MOUSE HUWE1_MOUSE YNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN LVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGD Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE LVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGD A2AFQ0_MOUSE A2AFQ0_MOUSE LVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGD Q4JG03_MOUSE Q4JG03_MOUSE LVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGD HUWE1_MOUSE HUWE1_MOUSE LVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGD MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN EQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQR Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE EQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQR A2AFQ0_MOUSE A2AFQ0_MOUSE EQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQR Q4JG03_MOUSE Q4JG03_MOUSE EQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQR HUWE1_MOUSE HUWE1_MOUSE EQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQR MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN PNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLK Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE PSTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLK A2AFQ0_MOUSE A2AFQ0_MOUSE PSTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLK Q4JG03_MOUSE Q4JG03_MOUSE PSTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLK HUWE1_MOUSE HUWE1_MOUSE PSTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLK MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN HIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVL Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE HIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVL A2AFQ0_MOUSE A2AFQ0_MOUSE HIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVL Q4JG03_MOUSE Q4JG03_MOUSE HIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVL HUWE1_MOUSE HUWE1_MOUSE HIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN GSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGS Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE GSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGS A2AFQ0_MOUSE A2AFQ0_MOUSE GSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGS Q4JG03_MOUSE Q4JG03_MOUSE GSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGS HUWE1_MOUSE HUWE1_MOUSE GSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGS MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN AVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHA Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE AVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHA A2AFQ0_MOUSE A2AFQ0_MOUSE AVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHA Q4JG03_MOUSE Q4JG03_MOUSE AVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHA HUWE1_MOUSE HUWE1_MOUSE AVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHA MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN AEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESIL Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE AEEASSEDEEEEEVQAMQSFNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESIL A2AFQ0_MOUSE A2AFQ0_MOUSE AEEASSEDEEEEEVQAMQSFNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESIL Q4JG03_MOUSE Q4JG03_MOUSE AEEASSEDEEEEEVQAMQSFNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESIL HUWE1_MOUSE HUWE1_MOUSE AEEASSEDEEEEEVQAMQSFNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESIL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN SNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVL Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE SNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVL A2AFQ0_MOUSE A2AFQ0_MOUSE SNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVL Q4JG03_MOUSE Q4JG03_MOUSE SNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVL HUWE1_MOUSE HUWE1_MOUSE SNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN QEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHA Q5H924_HUMAN Q5H924_HUMAN ------------------------------------------------------------ A2AFQ1_MOUSE A2AFQ1_MOUSE QEGLLQLDLILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHA A2AFQ0_MOUSE A2AFQ0_MOUSE QEGLLQLDLILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHA Q4JG03_MOUSE Q4JG03_MOUSE QEGLLQLDLILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHA HUWE1_MOUSE HUWE1_MOUSE QEGLLQLDLILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHA MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN YIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLP Q5H924_HUMAN Q5H924_HUMAN ---------------------------------------------------------SLP A2AFQ1_MOUSE A2AFQ1_MOUSE YIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLP A2AFQ0_MOUSE A2AFQ0_MOUSE YIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLP Q4JG03_MOUSE Q4JG03_MOUSE YIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLP HUWE1_MOUSE HUWE1_MOUSE YIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLP MATCH CONSENSUS ?????????????????????????????????????????????????????????SLP

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN SGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAP Q5H924_HUMAN Q5H924_HUMAN SGCEFGQADMQKLVPKDEKA---------DGEQDGAAGSMDASTQGLLEGIGLDGDTLAP A2AFQ1_MOUSE A2AFQ1_MOUSE SGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLAP A2AFQ0_MOUSE A2AFQ0_MOUSE SGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLAP Q4JG03_MOUSE Q4JG03_MOUSE SGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLAP HUWE1_MOUSE HUWE1_MOUSE SGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLAP MATCH CONSENSUS SGCEFGQADMQKLVPKDEKA?????????DGEQDG?AGSMDAS?QGLLEGI?LDGDTLAP

Q4RVZ2_TETNG Q4RVZ2_TETNG -------------------------------FTASSRLGRALAELFGLLVKLCVGSPVRQ HUWE1_HUMAN HUWE1_HUMAN METDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ Q5H924_HUMAN Q5H924_HUMAN METDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ A2AFQ1_MOUSE A2AFQ1_MOUSE METDEPSSSDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ A2AFQ0_MOUSE A2AFQ0_MOUSE METDEPSSSDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ Q4JG03_MOUSE Q4JG03_MOUSE METDEPSSSDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ HUWE1_MOUSE HUWE1_MOUSE METDEPSSSDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ MATCH ::*************************** CONSENSUS METDEP??SDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ

Q4RVZ2_TETNG Q4RVZ2_TETNG RRSHHATSTGTTPTPAARATASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM HUWE1_HUMAN HUWE1_HUMAN RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM Q5H924_HUMAN Q5H924_HUMAN RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM A2AFQ1_MOUSE A2AFQ1_MOUSE RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM A2AFQ0_MOUSE A2AFQ0_MOUSE RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM Q4JG03_MOUSE Q4JG03_MOUSE RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM HUWE1_MOUSE HUWE1_MOUSE RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM MATCH ******:** *:******:***************************************** CONSENSUS RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPM

Q4RVZ2_TETNG Q4RVZ2_TETNG LFDERKYPYHLMLQKFFCSGGHDALFETFNWALSMGGKVPVSEGLEHTDLPDGTGEFLDA HUWE1_HUMAN HUWE1_HUMAN LFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDA Q5H924_HUMAN Q5H924_HUMAN LFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDA A2AFQ1_MOUSE A2AFQ1_MOUSE LFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDA A2AFQ0_MOUSE A2AFQ0_MOUSE LFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDA Q4JG03_MOUSE Q4JG03_MOUSE LFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDA HUWE1_MOUSE HUWE1_MOUSE LFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDA MATCH ****************:*****:************************:************ CONSENSUS LFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDA

Q4RVZ2_TETNG Q4RVZ2_TETNG WLMLVEKMVNPSTVLDSPHSLPAKMPGVTPTIPQFSALRFLIVTQKAAFSCIRSLWNRKP HUWE1_HUMAN HUWE1_HUMAN WLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKP Q5H924_HUMAN Q5H924_HUMAN WLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKP A2AFQ1_MOUSE A2AFQ1_MOUSE WLMLVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWNRKP A2AFQ0_MOUSE A2AFQ0_MOUSE WLMLVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWNRKP Q4JG03_MOUSE Q4JG03_MOUSE WLMLVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWNRKP HUWE1_MOUSE HUWE1_MOUSE WLMLVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWNRKP MATCH ***********:***:********:** . .:*********:*******:**:.****** CONSENSUS WLMLVEKMVNPTTVLESPHSLPAKLPGGVQ?FPQFSALRFLVVTQKAAFTCIKNLWNRKP

Q4RVZ2_TETNG Q4RVZ2_TETNG LKVYGGRMAESMLAILCHILRGEPVIQERLAKEREGTVRTDDETGSTPGGLADESTNSTP HUWE1_HUMAN HUWE1_HUMAN LKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGS-RGEEDTGQEEGG---------S Q5H924_HUMAN Q5H924_HUMAN LKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGS-RGEEDTGQEEGG---------S A2AFQ1_MOUSE A2AFQ1_MOUSE LKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGS-RGEEEAGQEEGG---------S A2AFQ0_MOUSE A2AFQ0_MOUSE LKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGS-RGEEEAGQEEGG---------S Q4JG03_MOUSE Q4JG03_MOUSE LKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGS-RGEEEAGQEEGG---------S HUWE1_MOUSE HUWE1_MOUSE LKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGS-RGEEEAGQEEGG---------S MATCH **************************:***:**:**: * ::::*. ** . CONSENSUS LKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGS?RGEE??GQEEGG?????????S

Q4RVZ2_TETNG Q4RVZ2_TETNG RREPQVNQSQLTQLMDMGFSREHALEALLNTSTMEQATEYLLTHPPPLLGGAVRDLTMSE HUWE1_HUMAN HUWE1_HUMAN RREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSE Q5H924_HUMAN Q5H924_HUMAN RREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSE A2AFQ1_MOUSE A2AFQ1_MOUSE RREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSE A2AFQ0_MOUSE A2AFQ0_MOUSE RREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSE Q4JG03_MOUSE Q4JG03_MOUSE RREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSE HUWE1_MOUSE HUWE1_MOUSE RREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSE MATCH ********.** *******:****:**********************::**.****:*** CONSENSUS RREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPI?GGVVRDLSMSE

Q4RVZ2_TETNG Q4RVZ2_TETNG EDQMMRAIAMSLGQEVSMEQRSDSPEEAARRREEEDRRARERAEEEEARCLERFMEAEPL HUWE1_HUMAN HUWE1_HUMAN EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPL Q5H924_HUMAN Q5H924_HUMAN EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPL A2AFQ1_MOUSE A2AFQ1_MOUSE EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPL A2AFQ0_MOUSE A2AFQ0_MOUSE EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPL Q4JG03_MOUSE Q4JG03_MOUSE EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPL HUWE1_MOUSE HUWE1_MOUSE EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPL MATCH **************::.*:**::****.* *:***:*:***: *****:***:* :*:** CONSENSUS EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPL

Q4RVZ2_TETNG Q4RVZ2_TETNG DPKDLHTFTDSMLPGCFHLLDELPDTVYRLCDLLMTAIKRNGPEYRDLILGQVVHQVWEA HUWE1_HUMAN HUWE1_HUMAN EQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA Q5H924_HUMAN Q5H924_HUMAN EQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA A2AFQ1_MOUSE A2AFQ1_MOUSE EQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA A2AFQ0_MOUSE A2AFQ0_MOUSE EQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA Q4JG03_MOUSE Q4JG03_MOUSE EQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA HUWE1_MOUSE HUWE1_MOUSE EQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA MATCH : .:******:******************:***:********.:***:** ***:***** CONSENSUS EQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA

Q4RVZ2_TETNG Q4RVZ2_TETNG ADVLIKAAEPLTTSDTKTVSEWTRQMATLPQASKLATRILLLTLLFE------------- HUWE1_HUMAN HUWE1_HUMAN ADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESS Q5H924_HUMAN Q5H924_HUMAN ADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESS A2AFQ1_MOUSE A2AFQ1_MOUSE ADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESS A2AFQ0_MOUSE A2AFQ0_MOUSE ADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESS Q4JG03_MOUSE Q4JG03_MOUSE ADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESS HUWE1_MOUSE HUWE1_MOUSE ADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESS MATCH ******** ************* *********:************* CONSENSUS ADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESS

Q4RVZ2_TETNG Q4RVZ2_TETNG ------------------------------------------------------------ HUWE1_HUMAN HUWE1_HUMAN GILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQ Q5H924_HUMAN Q5H924_HUMAN GILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQ A2AFQ1_MOUSE A2AFQ1_MOUSE GILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQ A2AFQ0_MOUSE A2AFQ0_MOUSE GILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQ Q4JG03_MOUSE Q4JG03_MOUSE GILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQ HUWE1_MOUSE HUWE1_MOUSE GILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQ MATCH CONSENSUS GILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQ

Q4RVZ2_TETNG Q4RVZ2_TETNG --------------------------------------------------------VNEE HUWE1_HUMAN HUWE1_HUMAN SNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEE Q5H924_HUMAN Q5H924_HUMAN SNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEE A2AFQ1_MOUSE A2AFQ1_MOUSE SNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEE A2AFQ0_MOUSE A2AFQ0_MOUSE SNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEE Q4JG03_MOUSE Q4JG03_MOUSE SNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEE HUWE1_MOUSE HUWE1_MOUSE SNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEE MATCH **** CONSENSUS SNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEE

Q4RVZ2_TETNG Q4RVZ2_TETNG TGNRRPVMLTVQRVPRLPKPAKTGSTTDPEREEGEKSKALETHADLESSATLEIITPKDD HUWE1_HUMAN HUWE1_HUMAN TGNRRPVMLTLLRVPRLNKNSKNSNGQELEK-------------TLEESKEMDIKRKENK Q5H924_HUMAN Q5H924_HUMAN TGNRRPVMLTLLRVPRLNKNSKNSNGQELEK-------------TLEESKEMDIKRKENK A2AFQ1_MOUSE A2AFQ1_MOUSE TGNRRPVMLTLLRVPRLSKNSKSSNGQELEK-------------TLEESKETDIKHKENK A2AFQ0_MOUSE A2AFQ0_MOUSE TGNRRPVMLTLLRVPRLSKNSKSSNGQELEK-------------TLEESKETDIKHKENK Q4JG03_MOUSE Q4JG03_MOUSE TGNRRPVMLTLLRVPRLSKNSKSSNGQELEK-------------TLEESKETDIKHKENK HUWE1_MOUSE HUWE1_MOUSE TGNRRPVMLTLLRVPRLSKNSKSSNGQELEK-------------TLEESKETDIKHKENK MATCH **********: ***** * :*... : *: **.* :* ::. CONSENSUS TGNRRPVMLTLLRVPRL?KNSK?SNGQELEK?????????????TLEESKE?DIK?KENK

Q4RVZ2_TETNG Q4RVZ2_TETNG SNQLKETISVPSSSLES--DYSQGSDIVVQGLTEDMTTVLIRACVSMISVPVDPDTLHAT HUWE1_HUMAN HUWE1_HUMAN GNDTPLALESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHAT Q5H924_HUMAN Q5H924_HUMAN GNDTPLALESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHAT A2AFQ1_MOUSE A2AFQ1_MOUSE GNDIPLALESTNTEKEASLDETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHAT A2AFQ0_MOUSE A2AFQ0_MOUSE GNDIPLALESTNTEKEASLDETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHAT Q4JG03_MOUSE Q4JG03_MOUSE GNDIPLALEITNTEKEASLDETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHAT HUWE1_MOUSE HUWE1_MOUSE GNDIPLALESTNTEKEASLDETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHAT MATCH .*: ::. ..:. *: : :: .:*::*******.**********:.*********** CONSENSUS GND?PLALE?TNTEKE?SL?ETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHAT

Q4RVZ2_TETNG Q4RVZ2_TETNG LRLCLRLTRNHRYAMMFAELKSTRMILGLTQSSGFNGFTPLVTLLFRHIIEDPATLRHTM HUWE1_HUMAN HUWE1_HUMAN LRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM Q5H924_HUMAN Q5H924_HUMAN LRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM A2AFQ1_MOUSE A2AFQ1_MOUSE LRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM A2AFQ0_MOUSE A2AFQ0_MOUSE LRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM Q4JG03_MOUSE Q4JG03_MOUSE LRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM HUWE1_MOUSE HUWE1_MOUSE LRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM MATCH *********:*:***************.*****************:*******.****** CONSENSUS LRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM

Q4RVZ2_TETNG Q4RVZ2_TETNG EKVVRSAVTSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPECFVETASSCVRIALP HUWE1_HUMAN HUWE1_HUMAN EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP Q5H924_HUMAN Q5H924_HUMAN EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP A2AFQ1_MOUSE A2AFQ1_MOUSE EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP A2AFQ0_MOUSE A2AFQ0_MOUSE EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP Q4JG03_MOUSE Q4JG03_MOUSE EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP HUWE1_MOUSE HUWE1_MOUSE EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP MATCH *******.************************************: *.*.*..*:***** CONSENSUS EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP

Q4RVZ2_TETNG Q4RVZ2_TETNG APRGAGTASDDEFENLRIKGPNAVQLVKTTPVKLSALPTIPETIKDVIYDMLNALAAYHA HUWE1_HUMAN HUWE1_HUMAN APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHA Q5H924_HUMAN Q5H924_HUMAN APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHA A2AFQ1_MOUSE A2AFQ1_MOUSE APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALAAYHA A2AFQ0_MOUSE A2AFQ0_MOUSE APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALAAYHA Q4JG03_MOUSE Q4JG03_MOUSE APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALAAYHA HUWE1_MOUSE HUWE1_MOUSE APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALAAYHA MATCH ****:**************************:* *.**.**:***:************** CONSENSUS APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPS?LPVIPDTIKEVIYDMLNALAAYHA

Q4RVZ2_TETNG Q4RVZ2_TETNG PDEPERTEERAAVVPGG--QDLCQILQDVGDDVYQQYR-LTRQGSDFDSQSAFHINTQVF HUWE1_HUMAN HUWE1_HUMAN PEEADKSDPK----PGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVF Q5H924_HUMAN Q5H924_HUMAN PEEADKSDPK----PGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVF A2AFQ1_MOUSE A2AFQ1_MOUSE PEEADKSDPK----PGGTTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQVF A2AFQ0_MOUSE A2AFQ0_MOUSE PEEADKSDPK----PGGTTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQVF Q4JG03_MOUSE Q4JG03_MOUSE PEEADKSDPK----PGGTTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQVF HUWE1_MOUSE HUWE1_MOUSE PEEADKSDPK----PGGTTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQVF MATCH *:*.:::: : ** *:: *:***:********* ****.****:**.* :*:*** CONSENSUS PEEADKSDPK????PG??TQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFS?NSQVF

Q4RVZ2_TETNG Q4RVZ2_TETNG AADGAVPESSQSGTPQGEGKYKLNAPYRQLTIADKLLLFIPIFFFSFFNTQASTPEEMRE HUWE1_HUMAN HUWE1_HUMAN AADGASTETSASGTSQGE---------------------------------ASTPEESRD Q5H924_HUMAN Q5H924_HUMAN AADGASTETSASGTSQGE---------------------------------ASTPEESRD A2AFQ1_MOUSE A2AFQ1_MOUSE AADGAPAETSTTGTSQGE---------------------------------ASTPEETRE A2AFQ0_MOUSE A2AFQ0_MOUSE AADGAPAETSTTGTSQGEG--------------------------------ASTPEETRE Q4JG03_MOUSE Q4JG03_MOUSE AADGAPAETSTTGTSQGEG--------------------------------ASTPEETRE HUWE1_MOUSE HUWE1_MOUSE AADGAPAETSTTGTSQGE---------------------------------ASTPEETRE MATCH ***** .*:* :**.*** ****** *: CONSENSUS AADGA??ETS??GTSQGE?????????????????????????????????ASTPEE?R?

Q4RVZ2_TETNG Q4RVZ2_TETNG EKKEQEGEKNTSSEESKAAKVKASKPLMPTSTILRLLAELVRSYVGIATLIASYSYTAGQ HUWE1_HUMAN HUWE1_HUMAN GKKDKEGDR--ASEEGK-QKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQ Q5H924_HUMAN Q5H924_HUMAN GKKDKEGDR--ASEEGK-QKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQ A2AFQ1_MOUSE A2AFQ1_MOUSE GKKDKEGDR--TSEEGK-QKSKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQ A2AFQ0_MOUSE A2AFQ0_MOUSE GKKDKEGDR--TSEEGK-QKSKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQ Q4JG03_MOUSE Q4JG03_MOUSE GKKDKEGDR--TSEEGK-QKSKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQ HUWE1_MOUSE HUWE1_MOUSE GKKDKEGDR--TSEEGK-QKSKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQ MATCH **::**:: :***.* * *.*****************************.****.** CONSENSUS GKKDKEGDR???SEEGK?QK?KGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQ

Q4RVZ2_TETNG Q4RVZ2_TETNG SELIKEDCSVLAFVLDHLLPHTQNSEDKDTPALARLFLASLAAAGTGTDAQVALVNEVKA HUWE1_HUMAN HUWE1_HUMAN SELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKA Q5H924_HUMAN Q5H924_HUMAN SELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKA A2AFQ1_MOUSE A2AFQ1_MOUSE SELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKA A2AFQ0_MOUSE A2AFQ0_MOUSE SELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKA Q4JG03_MOUSE Q4JG03_MOUSE SELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKA HUWE1_MOUSE HUWE1_MOUSE SELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKA MATCH ************************:********************:************** CONSENSUS SELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKA

Q4RVZ2_TETNG Q4RVZ2_TETNG ALSRALAMPEGAEKHARLQAVMCIISTIMESCPSTSSFYSTAAAKTQHNGMNNIIRLFLK HUWE1_HUMAN HUWE1_HUMAN ALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLK Q5H924_HUMAN Q5H924_HUMAN ALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLK A2AFQ1_MOUSE A2AFQ1_MOUSE ALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLK A2AFQ0_MOUSE A2AFQ0_MOUSE ALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLK Q4JG03_MOUSE Q4JG03_MOUSE ALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLK HUWE1_MOUSE HUWE1_MOUSE ALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLK MATCH **.*****.*.:****************************:*:***************** CONSENSUS ALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLK

Q4RVZ2_TETNG Q4RVZ2_TETNG KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKGSSSKSKAEHD HUWE1_HUMAN HUWE1_HUMAN KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQD Q5H924_HUMAN Q5H924_HUMAN KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQD A2AFQ1_MOUSE A2AFQ1_MOUSE KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQD A2AFQ0_MOUSE A2AFQ0_MOUSE KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQD Q4JG03_MOUSE Q4JG03_MOUSE KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQD HUWE1_MOUSE HUWE1_MOUSE KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQD MATCH *************************************************.:***.*:*:* CONSENSUS KGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQD

Q4RVZ2_TETNG Q4RVZ2_TETNG TVGTARDTNSNTQDQGESGEAEPVEGNHRV---QGPDNDLMDGETEGDTVVIAGQPEVLS HUWE1_HUMAN HUWE1_HUMAN AQGASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLS Q5H924_HUMAN Q5H924_HUMAN AQGASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLS A2AFQ1_MOUSE A2AFQ1_MOUSE AQGASQDSSSHQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLS A2AFQ0_MOUSE A2AFQ0_MOUSE AQGASQDSSSHQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLS Q4JG03_MOUSE Q4JG03_MOUSE AQGASQDSSSHQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLS HUWE1_MOUSE HUWE1_MOUSE AQGASQDSSSHQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLS MATCH : *:::*:.*: ** **.**** * :* * : .*.*:****:* *:*********** CONSENSUS AQGASQDSSS?QQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLS

Q4RVZ2_TETNG Q4RVZ2_TETNG TQAMQVENELVDLIDELLERDAGTVNSTIIVGRSGEVESQEDVLMDEAPSNISQASTLQA HUWE1_HUMAN HUWE1_HUMAN SQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQA Q5H924_HUMAN Q5H924_HUMAN SQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQA A2AFQ1_MOUSE A2AFQ1_MOUSE SQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQA A2AFQ0_MOUSE A2AFQ0_MOUSE SQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQA Q4JG03_MOUSE Q4JG03_MOUSE SQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQA HUWE1_MOUSE HUWE1_MOUSE SQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQA MATCH :* ******* **********.*: ******.**** **************:******** CONSENSUS SQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQA

Q4RVZ2_TETNG Q4RVZ2_TETNG NREDSMNILEPEDEE-HTQEEDSSGSNDDE-DSQDEEEEEEEEEEEDQDD---EEGDEDD HUWE1_HUMAN HUWE1_HUMAN NREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDD Q5H924_HUMAN Q5H924_HUMAN NREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDD A2AFQ1_MOUSE A2AFQ1_MOUSE NREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDD A2AFQ0_MOUSE A2AFQ0_MOUSE NREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDD Q4JG03_MOUSE Q4JG03_MOUSE NREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDD HUWE1_MOUSE HUWE1_MOUSE NREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDD MATCH *********:***** ***********:** ***********:**:**:* ******* CONSENSUS NREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDD

Q4RVZ2_TETNG Q4RVZ2_TETNG DDEGSEMELDEDFPEINAAPHIRFERFDRDDDLIIEFDNMFSNNADIPPSPGNIPTSHPL HUWE1_HUMAN HUWE1_HUMAN DDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPL Q5H924_HUMAN Q5H924_HUMAN DDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPL A2AFQ1_MOUSE A2AFQ1_MOUSE DDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPL A2AFQ0_MOUSE A2AFQ0_MOUSE DDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPL Q4JG03_MOUSE Q4JG03_MOUSE DDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPL HUWE1_MOUSE HUWE1_MOUSE DDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPL MATCH **:*********:*::**:* :*******:************. :***********:*** CONSENSUS DDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPL

Q4RVZ2_TETNG Q4RVZ2_TETNG MVRHVDHGSLSLGVAGTSTRLAQGMGRSQRTLRQLTANSGHTIHVHYPGNRQPNPPLILQ HUWE1_HUMAN HUWE1_HUMAN MVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQ Q5H924_HUMAN Q5H924_HUMAN MVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQ A2AFQ1_MOUSE A2AFQ1_MOUSE MVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQ A2AFQ0_MOUSE A2AFQ0_MOUSE MVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQ Q4JG03_MOUSE Q4JG03_MOUSE MVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQ HUWE1_MOUSE HUWE1_MOUSE MVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQ MATCH ****.**.**:** ..::***:**:*************:********************* CONSENSUS MVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQ

Q4RVZ2_TETNG Q4RVZ2_TETNG RLLGPSAAADILQLSNSLPLQSRGRARLLVGNEDVHIIARSDDELLDDFFHEQSSTGGQA HUWE1_HUMAN HUWE1_HUMAN RLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQA Q5H924_HUMAN Q5H924_HUMAN RLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQA A2AFQ1_MOUSE A2AFQ1_MOUSE RLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQA A2AFQ0_MOUSE A2AFQ0_MOUSE RLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQA Q4JG03_MOUSE Q4JG03_MOUSE RLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQA HUWE1_MOUSE HUWE1_MOUSE RLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQA MATCH ***************.****************:******************:**:: .** CONSENSUS RLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQA

Q4RVZ2_TETNG Q4RVZ2_TETNG GTLSSIPTALTRWTDECKVLDAESMHDCVAVVKVPILQHLESLRDEELEERREKRRRQLA HUWE1_HUMAN HUWE1_HUMAN GTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLA Q5H924_HUMAN Q5H924_HUMAN GTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLA A2AFQ1_MOUSE A2AFQ1_MOUSE GTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLA A2AFQ0_MOUSE A2AFQ0_MOUSE GTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLA Q4JG03_MOUSE Q4JG03_MOUSE GTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLA HUWE1_MOUSE HUWE1_MOUSE GTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLA MATCH **************:**************:****.*::*** **************:*** CONSENSUS GTLSSIPTALTRWTEECKVLDAESMHDCVSVVKV?IVNHLEFLRDEELEERREKRRKQLA

Q4RVZ2_TETNG Q4RVZ2_TETNG EEE--------ESKQNERRASGAEQTREQSLQVNNCGISPPSEAVTPTTPAPHEQALVSL HUWE1_HUMAN HUWE1_HUMAN EEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSES Q5H924_HUMAN Q5H924_HUMAN EEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSES A2AFQ1_MOUSE A2AFQ1_MOUSE EEETKIIDKGKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSES A2AFQ0_MOUSE A2AFQ0_MOUSE EEETKIIDKGKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSES Q4JG03_MOUSE Q4JG03_MOUSE EEETKIIDKGKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSES HUWE1_MOUSE HUWE1_MOUSE EEETKIIDKGKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSES MATCH *** *.*:*. ::: . :: :. :* . ..* ****:. : . . CONSENSUS EEETKI?DKGKEDKENRDQSAQCT??K?NDSTEQN?SDGTPMPDSYPTTPSSTDA?TSES

Q4RVZ2_TETNG Q4RVZ2_TETNG ETAIG------QQVHQP-------IADLLQ--AESHTSSLAALAGTGLSLSGSERPNSEV HUWE1_HUMAN HUWE1_HUMAN KETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEA Q5H924_HUMAN Q5H924_HUMAN KETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEA A2AFQ1_MOUSE A2AFQ1_MOUSE KETLGTLQPSQQQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPTRPSGEA A2AFQ0_MOUSE A2AFQ0_MOUSE KETLGTLQPSQQQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPTRPSGEA Q4JG03_MOUSE Q4JG03_MOUSE KETLGTLQPSQQQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPTRPSGEA HUWE1_MOUSE HUWE1_MOUSE KETLGTLQPSQQQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPTRPSGEA MATCH : ::* ** * :.: ** * . .* * . *. **..*. CONSENSUS KETLGTLQ?SQQQP?LP?PP?LGE?PQELQSPA?E???STQLLMP?E?EELGPTRPSGEA

Q4RVZ2_TETNG Q4RVZ2_TETNG EASQMEMSPAPTTASLSPDIVESTEPAVVGVSQLEGSPMDTSSPASATQEE-----PATN HUWE1_HUMAN HUWE1_HUMAN ETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAG Q5H924_HUMAN Q5H924_HUMAN ETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAG A2AFQ1_MOUSE A2AFQ1_MOUSE ETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAG A2AFQ0_MOUSE A2AFQ0_MOUSE ETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAG Q4JG03_MOUSE Q4JG03_MOUSE ETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAG HUWE1_MOUSE HUWE1_MOUSE ETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAG MATCH *::***:***** :****: .*.::. .. ************ **.* ** .*:. CONSENSUS ETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDT?AAG

Q4RVZ2_TETNG Q4RVZ2_TETNG PAQTVQLSQELSGSGESGLTDRQTDAETGSTSVSSPGETMPRSDSADS------------ HUWE1_HUMAN HUWE1_HUMAN SSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGA Q5H924_HUMAN Q5H924_HUMAN SSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGA A2AFQ1_MOUSE A2AFQ1_MOUSE SSEQPTAGSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGA A2AFQ0_MOUSE A2AFQ0_MOUSE SSEQPTAGSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGA Q4JG03_MOUSE Q4JG03_MOUSE SSEQPTAGSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGA HUWE1_MOUSE HUWE1_MOUSE SSEQPTAGSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGA MATCH .:: ... .*.. . ::: * .: . * ..* :: * :.* .* CONSENSUS SSEQP?AGSSTPGDAP??VAEVQGR?D?S?ES?QPPEDSSPPASSESSSTRDSAVAISGA

Q4RVZ2_TETNG Q4RVZ2_TETNG QSQAIQEEPLPSTSNEEEDPLAGISLPEGVDPSFLAALPEDIRREVLQNQLGIRPPSRPP HUWE1_HUMAN HUWE1_HUMAN DSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTR-- Q5H924_HUMAN Q5H924_HUMAN DSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTR-- A2AFQ1_MOUSE A2AFQ1_MOUSE DSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTR-- A2AFQ0_MOUSE A2AFQ0_MOUSE DSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTR-- Q4JG03_MOUSE Q4JG03_MOUSE DSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTR-- HUWE1_MOUSE HUWE1_MOUSE DSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTR-- MATCH :*:.* ********.************************:****************:* CONSENSUS DSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTR??

Q4RVZ2_TETNG Q4RVZ2_TETNG VSASLSSTTAP-VLGGPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQQPPQGDT HUWE1_HUMAN HUWE1_HUMAN -TAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNAS-SDT Q5H924_HUMAN Q5H924_HUMAN -TAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNAS-SDT A2AFQ1_MOUSE A2AFQ1_MOUSE -SAPSSNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNAS-SDT A2AFQ0_MOUSE A2AFQ0_MOUSE -SAPSSNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNAS-SDT Q4JG03_MOUSE Q4JG03_MOUSE -SAPSSNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNAS-SDT HUWE1_MOUSE HUWE1_MOUSE -SAPSSNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNAS-SDT MATCH :*. :.::** *:*.*************************************:.. .** CONSENSUS ??APS?NSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNAS?SDT

Q4RVZ2_TETNG Q4RVZ2_TETNG PLDPVTFIQTLPSELRRSVLEDMEDSVLAVMPPDIAAEAAALRREQEARQRQLMHERLFG HUWE1_HUMAN HUWE1_HUMAN PMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFG Q5H924_HUMAN Q5H924_HUMAN PMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFG A2AFQ1_MOUSE A2AFQ1_MOUSE PMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFG A2AFQ0_MOUSE A2AFQ0_MOUSE PMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFG Q4JG03_MOUSE Q4JG03_MOUSE PMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFG HUWE1_MOUSE HUWE1_MOUSE PMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFG MATCH *:***********:************************* ******************** CONSENSUS PMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFG

Q4RVZ2_TETNG Q4RVZ2_TETNG HSSSSALSAILRSPAFTSRLGSNRGVQYTRLAVQRGGTFQMGGGTNH-RPSGSSVDSLLR HUWE1_HUMAN HUWE1_HUMAN HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLR Q5H924_HUMAN Q5H924_HUMAN HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLR A2AFQ1_MOUSE A2AFQ1_MOUSE HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLR A2AFQ0_MOUSE A2AFQ0_MOUSE HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLR Q4JG03_MOUSE Q4JG03_MOUSE HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLR HUWE1_MOUSE HUWE1_MOUSE HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLR MATCH ***:****************..*********************.:.* *****.**:*** CONSENSUS HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLR

Q4RVZ2_TETNG Q4RVZ2_TETNG LRGRL-----PLSCLLVLLFVDEPTLNTSRLHRVLRNLCYHSQTRGWVIRSLLSILQRSS HUWE1_HUMAN HUWE1_HUMAN LRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS Q5H924_HUMAN Q5H924_HUMAN LRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS A2AFQ1_MOUSE A2AFQ1_MOUSE LRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS A2AFQ0_MOUSE A2AFQ0_MOUSE LRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS Q4JG03_MOUSE Q4JG03_MOUSE LRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS HUWE1_MOUSE HUWE1_MOUSE LRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS MATCH ***** .*************.****************:*** ************** CONSENSUS LRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS

Q4RVZ2_TETNG Q4RVZ2_TETNG ESEVCVETPRL--EDSRGKRNSQGSCGGKGTASSLSSSSSSSSSSLELLNRVESRSSSQL HUWE1_HUMAN HUWE1_HUMAN ESELCIETPKLTTSEEKGKKSSK-SCG----------SSSHENRPLDLLHKMESKSSNQL Q5H924_HUMAN Q5H924_HUMAN ESELCIETPKLTTSEEKGKKSSK-SCG----------SSSHENRPLDLLHKMESKSSNQL A2AFQ1_MOUSE A2AFQ1_MOUSE ESELCIETPKLSTSEERGKKSSK-SCA----------SSSHENRPLDLLHKMESKSSNQL A2AFQ0_MOUSE A2AFQ0_MOUSE ESELCIETPKLSTSEERGKKSSK-SCA----------SSSHENRPLDLLHKMESKSSNQL Q4JG03_MOUSE Q4JG03_MOUSE ESELCIETPKLSTSEERGKKSSK-SCA----------SSSHENRPLDLLHKMESKSSNQL HUWE1_MOUSE HUWE1_MOUSE ESELCIETPKLSTSEERGKKSSK-SCA----------SSSHENRPLDLLHKMESKSSNQL MATCH ***:*:***:* .:.:**:.*: **. *** .. .*:**:::**:**.** CONSENSUS ESELCIETPKL?TSEE?GKKSSK?SC???????????SSSHENRPLDLLHKMESKSSNQL

Q4RVZ2_TETNG Q4RVZ2_TETNG SWLSVSMDAALGCRTNIFQIQRVSSRKHADRHSTGVTCGGGGGTTVHIHPQAAPVVCRHV HUWE1_HUMAN HUWE1_HUMAN SWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHAS-------GGSTVHIHPQAAPVVCRHV Q5H924_HUMAN Q5H924_HUMAN SWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHAS-------GGSTVHIHPQAAPVVCRHV A2AFQ1_MOUSE A2AFQ1_MOUSE SWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHAS-------SGSTVHIHPQAAPVVCRHV A2AFQ0_MOUSE A2AFQ0_MOUSE SWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHAS-------SGSTVHIHPQAAPVVCRHV Q4JG03_MOUSE Q4JG03_MOUSE SWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHAS-------SGSTVHIHPQAAPVVCRHV HUWE1_MOUSE HUWE1_MOUSE SWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHAS-------SGSTVHIHPQAAPVVCRHV MATCH ********************** ..***:::*:: .*:**************** CONSENSUS SWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHAS????????GSTVHIHPQAAPVVCRHV

Q4RVZ2_TETNG Q4RVZ2_TETNG LDTLIQLAKVFPSHFTQQRLPQPQSNTTSNSSTQNSLGATAANLQSLGISTDFWDLLVKL HUWE1_HUMAN HUWE1_HUMAN LDTLIQLAKVFPSHFTQQRTKETNCESDRERGNKA-CSPCSSQSSSSGICTDFWDLLVKL Q5H924_HUMAN Q5H924_HUMAN LDTLIQLAKVFPSHFTQQRTKETNCESDRERGNKA-CSPCSSQSSSSGICTDFWDLLVKL A2AFQ1_MOUSE A2AFQ1_MOUSE LDTLIQLAKVFPSHFTQQRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKL A2AFQ0_MOUSE A2AFQ0_MOUSE LDTLIQLAKVFPSHFTQQRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKL Q4JG03_MOUSE Q4JG03_MOUSE LDTLIQLAKVFPSHFTQQRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKL HUWE1_MOUSE HUWE1_MOUSE LDTLIQLAKVFPSHFTQQRTKETNCE