Alignment of the gene Family HBG080559 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
B9EKX1_MOUSE B9EKX1_MOUSE ----------------MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSAL B4DTR9_HUMAN B4DTR9_HUMAN ------------------------------------------------------------ B2RPC0_HUMAN B2RPC0_HUMAN ------------------------------------------------------------ B4DRK3_HUMAN B4DRK3_HUMAN CFLRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSAL CF138_HUMAN CF138_HUMAN ----------------MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSAL PTHD1_DANRE PTHD1_DANRE ----------------MLRQVIHRGLKASFYWLGLFVSRHPVFFLTVPAVLTIIFGSTVL Q4RF24_TETNG Q4RF24_TETNG ------GASACRILWRMLRQVIHRGLKASFYWLGLFVSRHPVFFLTVPAVLTIIFGSTVL Q4S1N7_TETNG Q4S1N7_TETNG ----------------LFEQL--------------------------------------- B1AZU9_MOUSE B1AZU9_MOUSE ----------------MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGAS-F PTHD1_MOUSE PTHD1_MOUSE ----------------MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGAS-F B4DQH0_HUMAN B4DQH0_HUMAN ----------------MLRQALHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGAS-F PTHD1_HUMAN PTHD1_HUMAN ----------------MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGAS-F MATCH CONSENSUS ???????????????????Q????????????????????????????????????????

B9EKX1_MOUSE B9EKX1_MOUSE NRFQTEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSSPG B4DTR9_HUMAN B4DTR9_HUMAN ------------------------------------------------------------ B2RPC0_HUMAN B2RPC0_HUMAN ------------------------------------------------------------ B4DRK3_HUMAN B4DRK3_HUMAN NRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTG CF138_HUMAN CF138_HUMAN NRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTG PTHD1_DANRE PTHD1_DANRE SRFKPETDLEILVAPTHSLAKIERSLANSLFPIDQSKHKLYSDLHTPGRYGRLILLARSG Q4RF24_TETNG Q4RF24_TETNG SRFKPETDLEVLVAPTHSLAKIERSLANSLFPIDQSKHKLYSDLHTPGRYGRLILLARSG Q4S1N7_TETNG Q4S1N7_TETNG ------------------------------------HSQIYQ------------------ B1AZU9_MOUSE B1AZU9_MOUSE SRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSYQK PTHD1_MOUSE PTHD1_MOUSE SRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSYQK B4DQH0_HUMAN B4DQH0_HUMAN SRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQK PTHD1_HUMAN PTHD1_HUMAN SRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQK MATCH CONSENSUS ????????????????????????????????????????Y???????????????????

B9EKX1_MOUSE B9EKX1_MOUSE DNILLQ--AEGILQTHRAVMEMKVNHKGYNYTFSHLCVLRNQDKKCVLDDIISVLEDLRQ B4DTR9_HUMAN B4DTR9_HUMAN ------------------------------------------------------------ B2RPC0_HUMAN B2RPC0_HUMAN ------------------------------------------------------------ B4DRK3_HUMAN B4DRK3_HUMAN DNILLQ--AEGILQTHRAVLEM-------------------------------------- CF138_HUMAN CF138_HUMAN DNILLQ--AEGILQTHRAVLEM-------------------------------------- PTHD1_DANRE PTHD1_DANRE GNILEL--AEQVLQVHKKVLDMRVNYKGFNYTFAHLCVLRHRDKRCLLDDIITIFEDIRL Q4RF24_TETNG Q4RF24_TETNG GNILEL--ADQVLQVHKQVLDLRVNYKGFNYTFAHLCVLRHRDKRCLLDDIITIFEDIRQ Q4S1N7_TETNG Q4S1N7_TETNG -------------------MQVTVPTSTFNYSFSYLCLH-DEKNVCIIDDIIRAMEEIQL B1AZU9_MOUSE B1AZU9_MOUSE ANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAHICVL-NNDKTCIVDDIVHVLEELKN PTHD1_MOUSE PTHD1_MOUSE ANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAHICVL-NNDKTCIVDDIVHVLEELKN B4DQH0_HUMAN B4DQH0_HUMAN ANMLDQHHTDLILKLHAAVTKIQVPRPGFNYTFAHICIL-NNDKTCIVDDIVHVLEELKN PTHD1_HUMAN PTHD1_HUMAN ANMLDQHHTDLILKLHAAVTKIQVPRPGFNYTFAHICIL-NNDKTCIVDDIVHVLEELKN MATCH CONSENSUS ????????????????????????????????????????????????????????????

B9EKX1_MOUSE B9EKX1_MOUSE AAVSNKTTARVQVRYPNTKLKDGRNSFIGHQLGGVV----------EVPNSKDQRVKSAR B4DTR9_HUMAN B4DTR9_HUMAN ------------------------------------------------------------ B2RPC0_HUMAN B2RPC0_HUMAN ------------------------------------------------------------ B4DRK3_HUMAN B4DRK3_HUMAN --------------------KDGRNSFIGHQLGGVV----------EVPNSKDQRVKSAR CF138_HUMAN CF138_HUMAN --------------------KDGRNSFIGHQLGGVV----------EVPNSKDQRVKSAR PTHD1_DANRE PTHD1_DANRE AVLSNSTFSKVPVSYPNTTLKDGRVSFIGHQLGGVA----------LPANNRDQQVKFAR Q4RF24_TETNG Q4RF24_TETNG AVLSNSTFHKVPVSYPNTTLKDGRVSFIGHQLGGVS----------FSPNSRDQQVKFAR Q4S1N7_TETNG Q4S1N7_TETNG ARSSNRS--APALHYPITRLTDGRQAYIGHQLGGVQGWGPGGSVHGPRAGARGEGVRSAR B1AZU9_MOUSE B1AZU9_MOUSE ARATNRT--NFAITYPITHLKDGRAVYNGHQLGGVT-------------VHSKDRVKSAE PTHD1_MOUSE PTHD1_MOUSE ARATNRT--NFAITYPITHLKDGRAVYNGHQLGGVT-------------VHSKDRVKSAE B4DQH0_HUMAN B4DQH0_HUMAN ARATNRT--NFAITYPITHLKDGRAVYNGHQLGGVT-------------VHSKDRVKSAE PTHD1_HUMAN PTHD1_HUMAN ARATNRT--NFAITYPITHLKDGRAVYNGHQLGGVT-------------VHSKDRVKSAE MATCH CONSENSUS ?????????????????????DGR????GHQLGGV????????????????????V??A?

B9EKX1_MOUSE B9EKX1_MOUSE AIQITYYLQTYGSATQDLIGEKWENEFCKLMRKLQEEHQ-----DLQLYSLASFSLWRDF B4DTR9_HUMAN B4DTR9_HUMAN ------------------------------------------------------------ B2RPC0_HUMAN B2RPC0_HUMAN ------------------------------------------------------------ B4DRK3_HUMAN B4DRK3_HUMAN AIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQ-----ELQLYSLASFSLWRDF CF138_HUMAN CF138_HUMAN AIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQ-----ELQLYSLASFSLWRDF PTHD1_DANRE PTHD1_DANRE AIQITYYLRNLGPVVQDIIAEKWETEFCKLVHQLATDSQ-----ELHIQSLTSFSLWRDF Q4RF24_TETNG Q4RF24_TETNG AVQITYYLSNHGPAMQDVIAERWENEFCALVDRLSTAEAPHATDQLHIHSLTSFSLWRDF Q4S1N7_TETNG Q4S1N7_TETNG ALQLTYYLQGRGE-LMDRVASQWEKAFCTELQHFAALHP-----KLGLYPSTSSSLKTDF B1AZU9_MOUSE B1AZU9_MOUSE AIQLTYYLQSINS-LNDMVAERWESSFCDTVKLFQKSNS-----KVKIYPYTSSSLREDF PTHD1_MOUSE PTHD1_MOUSE AIQLTYYLQSINS-LNDMVAERWESSFCDTVKLFQKSNS-----KVKIYPYTSSSLREDF B4DQH0_HUMAN B4DQH0_HUMAN AIQLTYYLQSINS-LNDMVAERWESSFCDTVRLFQKSNS-----KVKMYPYTSSSLREDF PTHD1_HUMAN PTHD1_HUMAN AIQLTYYLQSINS-LNDMVAERWESSFCDTVRLFQKSNS-----KVKMYPYTSSSLREDF MATCH CONSENSUS A?Q?TYYL????????D?????WE??FC????????????????????????S?SL??DF

B9EKX1_MOUSE B9EKX1_MOUSE HKTSILTRSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIATAAGIFFIT B4DTR9_HUMAN B4DTR9_HUMAN ---------------------------MKDCLRSKPFLGLLGVLTVCISIITAAGIFFIT B2RPC0_HUMAN B2RPC0_HUMAN ------------------------------------------------------------ B4DRK3_HUMAN B4DRK3_HUMAN HKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFIT CF138_HUMAN CF138_HUMAN HKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFIT PTHD1_DANRE PTHD1_DANRE HKTGVLAKSEVLVSLVLVLLAATISSSMRDCLRGKPFLGLLGVLTICIANVTAAGIFFIS Q4RF24_TETNG Q4RF24_TETNG HQTGVLAKGEVLVSLVLVLLAATISSSMRDCLRGKPFLGLLGVLTICIANVTAAGIFFIS Q4S1N7_TETNG Q4S1N7_TETNG QFSSVLARRPLLASLGLCGVLAVLCCSMRDCVRSKPWLGLLALLSVTLSGLTAAGILNLT B1AZU9_MOUSE B1AZU9_MOUSE QKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLT PTHD1_MOUSE PTHD1_MOUSE QKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLT B4DQH0_HUMAN B4DQH0_HUMAN QKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLT PTHD1_HUMAN PTHD1_HUMAN QKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLT MATCH CONSENSUS ?????????????SL?L????A????SM?DC?R?KP?LGLLG??T??????TAAGI????

B9EKX1_MOUSE B9EKX1_MOUSE DGKYNSTLLGIPFFAMG-----------------------------HGTKGVFELLSGWR B4DTR9_HUMAN B4DTR9_HUMAN DGKYNSTLLGIPFFAMG-----------------------------HGTKGVFELLSGWR B2RPC0_HUMAN B2RPC0_HUMAN ------------------------------------------------------------ B4DRK3_HUMAN B4DRK3_HUMAN DGKYNSTLLGIPFFAMG-----------------------------HGTKGVFELLSGWR CF138_HUMAN CF138_HUMAN DGKYNSTLLGIPFFAMG-----------------------------HGTKGVFELLSGWR PTHD1_DANRE PTHD1_DANRE DGKFNSTLLGIPFFAMG-----------------------------HGTKGVFELLAGWR Q4RF24_TETNG Q4RF24_TETNG DGKFNSTLLGIPFFAMGETVDATPSISPSQSATRLVVMVIKEGVWCHGTKGVFELLAGWR Q4S1N7_TETNG Q4S1N7_TETNG GATYNSTYLGIPFVMLG-----------------------------HGLFGSFEMLSSWR B1AZU9_MOUSE B1AZU9_MOUSE GGKYNSTFLGVPFVMLG-----------------------------HGLYGTFEMLSSWR PTHD1_MOUSE PTHD1_MOUSE GGKYNSTFLGVPFVMLG-----------------------------HGLYGTFEMLSSWR B4DQH0_HUMAN B4DQH0_HUMAN GGKYNSTFLGVPFVMLG-----------------------------HGLYGTFEMLSSWR PTHD1_HUMAN PTHD1_HUMAN GGKYNSTFLGVPFVMLG-----------------------------HGLYGTFEMLSSWR MATCH CONSENSUS ?GK?NST?LG?PF???G?????????????????????????????HG??G?FE?L??WR

B9EKX1_MOUSE B9EKX1_MOUSE RTKENLPFKDRVADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKIFCQNMCVSILL B4DTR9_HUMAN B4DTR9_HUMAN RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL B2RPC0_HUMAN B2RPC0_HUMAN -------------------MVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL B4DRK3_HUMAN B4DRK3_HUMAN RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL CF138_HUMAN CF138_HUMAN RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILL PTHD1_DANRE PTHD1_DANRE RTRESLPFKERVADAFADVMVCYTMTSSLYIITFGMGASPFTNIESVKVFCQSMCVAVLV Q4RF24_TETNG Q4RF24_TETNG RTRENLPFKERVADAFADVMVCYTMTSSLYIITFGMGASPFTNIESVKIFCQSMCVAILV Q4S1N7_TETNG Q4S1N7_TETNG RTREDQHVKERMASVFEDVMLRFSGSTLIHLLTLGLAASPLTNMEAVRLFCRTASLAVTI B1AZU9_MOUSE B1AZU9_MOUSE KTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAILF PTHD1_MOUSE PTHD1_MOUSE KTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAILF B4DQH0_HUMAN B4DQH0_HUMAN KTREDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFF PTHD1_HUMAN PTHD1_HUMAN KTREDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFF MATCH *: :: :: ::::*:*:.***:**:*:.::** . .::: . CONSENSUS ?T?E????K?R?A????D?M?????T???Y??TFG?GASPFTNIEA???FC???C??I??

B9EKX1_MOUSE B9EKX1_MOUSE NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQ--TSH B4DTR9_HUMAN B4DTR9_HUMAN NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQ--TSH B2RPC0_HUMAN B2RPC0_HUMAN NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQ--TSH B4DRK3_HUMAN B4DRK3_HUMAN NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQ--TSH CF138_HUMAN CF138_HUMAN NYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQ--TSH PTHD1_DANRE PTHD1_DANRE NYFYVFSFYGSCLVFAGQLEQNRYHSVFCCKIPSVEYLDRQPTWFKTMMSDGHDL--STH Q4RF24_TETNG Q4RF24_TETNG NYFYVFSFYGSCLVFAGQLEQNRYHSVFCCKIPSVEYLDRQPTWFKTMMSDGHDL--STH Q4S1N7_TETNG Q4S1N7_TETNG SYIYMLSFYGSCLVFTGYLETGYRHGCFCRRVPKPDRLDSKPAWYRCLMYTRYQEETQNH B1AZU9_MOUSE B1AZU9_MOUSE NYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPDVLQEKPAWYRFLLTARFSEETAEG PTHD1_MOUSE PTHD1_MOUSE NYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPDVLQEKPAWYRFLLTARFSEETAEG B4DQH0_HUMAN B4DQH0_HUMAN NYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEG PTHD1_HUMAN PTHD1_HUMAN NYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEG MATCH .*:*::**:**.***:* :* . *. ** ::*. : *: :*.*:: :: .. CONSENSUS NY?Y??SF?GS?LVF?G??E?N??HS?FC?K?P????L??KP?W????????????????

B9EKX1_MOUSE B9EKX1_MOUSE H--------------------------------------------ETNPYQHHFIQHFLR B4DTR9_HUMAN B4DTR9_HUMAN H--------------------------------------------ETNPYQHHFIQHFLR B2RPC0_HUMAN B2RPC0_HUMAN H--------------------------------------------ETNPYQHHFIQHFLR B4DRK3_HUMAN B4DRK3_HUMAN H--------------------------------------------ETNPYQHHFIQHFLR CF138_HUMAN CF138_HUMAN H--------------------------------------------ETNPYQHHFIQHFLR PTHD1_DANRE PTHD1_DANRE H--------------------------------------------DSVPYQNHFIQHFLR Q4RF24_TETNG Q4RF24_TETNG H--------------------------------------------DSVPYQNHFIQHFLR Q4S1N7_TETNG Q4S1N7_TETNG QPHGVGPGNAPTTNLTHTHTTHHPEAHGHDCTANSTHPQPPSSAGEPHPQDSHLLLGCVR B1AZU9_MOUSE B1AZU9_MOUSE E--------------------------------------------EANTYESHLLVCFLK PTHD1_MOUSE PTHD1_MOUSE E--------------------------------------------EANTYESHLLVCFLK B4DQH0_HUMAN B4DQH0_HUMAN E--------------------------------------------EANTYESHLLVCFLK PTHD1_HUMAN PTHD1_HUMAN E--------------------------------------------EANTYESHLLVCFLK MATCH . :. . : *:: :: CONSENSUS ?????????????????????????????????????????????E???Y??H????FL?

B9EKX1_MOUSE B9EKX1_MOUSE EHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGASIINLLASDSPSVSYAMVQQKY B4DTR9_HUMAN B4DTR9_HUMAN EHYNEWITNIYVKPLVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKY B2RPC0_HUMAN B2RPC0_HUMAN EHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKY B4DRK3_HUMAN B4DRK3_HUMAN EHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKY CF138_HUMAN CF138_HUMAN EHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKY PTHD1_DANRE PTHD1_DANRE EHYTEWITNTYVKPFVVILYLIYASFSFMGCLQISDGSNIINLLASNSPSVSFALTQQKY Q4RF24_TETNG Q4RF24_TETNG EHYTEWITNTYVKPFVVILYLIYASFSFMGCLQISDGSNIVNLLASNSPSVSFALTQQKY Q4S1N7_TETNG Q4S1N7_TETNG HCFGDWITNTYVKPFVVLLYLVYISFGLMGFLQITQGSDPSALVAMDTATVSYTRAQQRY B1AZU9_MOUSE B1AZU9_MOUSE RYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKY PTHD1_MOUSE PTHD1_MOUSE RYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKY B4DQH0_HUMAN B4DQH0_HUMAN RYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKY PTHD1_HUMAN PTHD1_HUMAN RYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKY MATCH . : :**** ****:**::**:* **.:** **:::*:. ::* : ::.:: .:*:* CONSENSUS ??Y??WITN?YVKPFVV??YLIY?SF??MG?LQ?S?G????N??A???????Y???QQKY

B9EKX1_MOUSE B9EKX1_MOUSE FSNYSPVIGFYVYEPLEYWNSSVQEDLQRLCSGFTAVSWVEQYYQFLKTSNISANN-KTD B4DTR9_HUMAN B4DTR9_HUMAN FSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANN-KSD B2RPC0_HUMAN B2RPC0_HUMAN FSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANN-KSD B4DRK3_HUMAN B4DRK3_HUMAN FSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANN-KSD CF138_HUMAN CF138_HUMAN FSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANN-KSD PTHD1_DANRE PTHD1_DANRE FSNYSPVIGFYIYEPIEYWNSTVQEHLKTLGQGFNKISWIDNYFHFLRVVNISAST-KSD Q4RF24_TETNG Q4RF24_TETNG FSNYSPVIGFYIYEPIEYWNSTVQEHLKTLSHGFNKISWMDNFFHYLKVVNVSAST-KND Q4S1N7_TETNG Q4S1N7_TETNG FSSYSPVIGFYIYESAPYWNASVQQDLLEYAKGFQRISWLEAYLNYLSERNQSTSQPREN B1AZU9_MOUSE B1AZU9_MOUSE FNNYSPVIGFYIYESIEYWNSSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTDLPKKN PTHD1_MOUSE PTHD1_MOUSE FNNYSPVIGFYIYESIEYWNSSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTDLPKKN B4DQH0_HUMAN B4DQH0_HUMAN FSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTGLPKKN PTHD1_HUMAN PTHD1_HUMAN FSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTGLPKKN MATCH *..********:**. ***::**:.: ** :**.: : ::* * *:. : : CONSENSUS FSNYSPVIGFY?YE??EYWN?SVQ?D??????GF???SW?E?Y???L???N?S????K??

B9EKX1_MOUSE B9EKX1_MOUSE FISVLQSSFLKKPEFQHFRNDIIFSRA--GDENNIIASRLYLVARTSRDKQKEVIEVLDK B4DTR9_HUMAN B4DTR9_HUMAN FISVLQSSFLKKPEFQHFRNDIIFSKA--GDESNIIASRLYLVARTSRDKQKEITEVLEK B2RPC0_HUMAN B2RPC0_HUMAN FISVLQSSFLKKPEFQHFRNDIIFSKA--GDESNIIASRLYLVARTSRDKQKEITEVLEK B4DRK3_HUMAN B4DRK3_HUMAN FISVLQSSFLKKPEFQHFRNDIIFSKA--GDESNIIASRLYLVARTSRDKQKEITEVLEK CF138_HUMAN CF138_HUMAN FISVLQSSFLKKPEFQHFRNDIIFSKA--GDESNIIASRLYLVARTSRDKQKEITEVLEK PTHD1_DANRE PTHD1_DANRE FISILKTSFLRSPEYQHFVDDIIFSKN--GAEYDIIASKMYLVARTTEKTREEVVELLER Q4RF24_TETNG Q4RF24_TETNG FINILKDSFLRSPEYQHFTEDVIFSKNRETDEYNIIASRMYLVARTTEKKREEVVELLEK Q4S1N7_TETNG Q4S1N7_TETNG FTRTLRHLFLREPQFAHFADDIIFAERGQGEEPDLAASRIFLVAKTTENKREEMSVLLDT B1AZU9_MOUSE B1AZU9_MOUSE FTDMLRNSFLKTPQFSHFQEDIIFSKK-YNDEVDVVASRMFLVAKTMETNREELYDLLET PTHD1_MOUSE PTHD1_MOUSE FTDMLRNSFLKTPQFSHFQEDIIFSKK-YNDEVDVVASRMFLVAKTMETNREELYDLLET B4DQH0_HUMAN B4DQH0_HUMAN FTDMLRNSFLKAPQFSHFQEDIIFSKK-YNDEVDVVASRMFLVAKTMETNREELYDLLET PTHD1_HUMAN PTHD1_HUMAN FTDMLRNSFLKAPQFSHFQEDIIFSKK-YNDEVDVVASRMFLVAKTMETNREELYDLLET MATCH * *: **: *:: ** :*:**:. * :: **:::***:* . .::*: :*: CONSENSUS F???L??SFL??P?F?HF??DIIFSK????DE????ASR??LVA?T??????E????LE?

B9EKX1_MOUSE B9EKX1_MOUSE LRPLSLSKSIRFIVFNPSFVFTDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWL B4DTR9_HUMAN B4DTR9_HUMAN LRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWL B2RPC0_HUMAN B2RPC0_HUMAN LRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWL B4DRK3_HUMAN B4DRK3_HUMAN LRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWL CF138_HUMAN CF138_HUMAN LRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWL PTHD1_DANRE PTHD1_DANRE LRPLSLINSIKFIVFNPTFVFMDRYSSSIISPILTSGFSVLTILILTFFLVINPLGNFWL Q4RF24_TETNG Q4RF24_TETNG LRPLMLINSIKFIAFNPTFVFMDRYSSSVISPILTSGFSVLTILILTFFLVINPLGNFWL Q4S1N7_TETNG Q4S1N7_TETNG LRRLSLTSRVRFLIFNPSFVYLDRYATAVSSPLRHSLLAVLFLLGLSSLAVVEPLVSVWL B1AZU9_MOUSE B1AZU9_MOUSE LRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWI PTHD1_MOUSE PTHD1_MOUSE LRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWI B4DQH0_HUMAN B4DQH0_HUMAN LRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWI PTHD1_HUMAN PTHD1_HUMAN LRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWI MATCH ** * : . ::*: ***:**: *:*: :: *: : :..* :* :: : * ..* ..*: CONSENSUS LR?LS??????FIVFNPSFV?MD?Y??S???P????????L??L????FLV???L?N?W?

B9EKX1_MOUSE B9EKX1_MOUSE ILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLYTFVLATEHTRTQCI B4DTR9_HUMAN B4DTR9_HUMAN ILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCI B2RPC0_HUMAN B2RPC0_HUMAN ILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCI B4DRK3_HUMAN B4DRK3_HUMAN ILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCI CF138_HUMAN CF138_HUMAN ILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCI PTHD1_DANRE PTHD1_DANRE ILTVTSVELGVLGLMTLWNVDMDSISILCLIYTLNFAMDHCAPHLYTFVLATEHTRTQCI Q4RF24_TETNG Q4RF24_TETNG ILTVTSVELGVLGLMTLWNVGMDSISILCLIYTLNFAMDHCAPHLYTFVLATEHTRTQCI Q4S1N7_TETNG Q4S1N7_TETNG GLTLLSVQFGVLGFMTLWGVELDCMSVLCLISALGHSADCSGPLLCGFASGRGDSRTRWV B1AZU9_MOUSE B1AZU9_MOUSE TLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWV PTHD1_MOUSE PTHD1_MOUSE TLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWV B4DQH0_HUMAN B4DQH0_HUMAN TLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKDFTRTKWV PTHD1_HUMAN PTHD1_HUMAN TLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKDFTRTKWV MATCH *:: *:::**:*:**** * :*.:*:**** :..: * ..* * *. . :**: : CONSENSUS ?L?V?S?E?GV?G?MTLW?V??DCIS?LCLIY??N???D?CAP?L?TFVL????TRT???

B9EKX1_MOUSE B9EKX1_MOUSE KSSLQEHGT-AILQNITSFLIGLLPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFL B4DTR9_HUMAN B4DTR9_HUMAN KSSLQDHGT-AILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFL B2RPC0_HUMAN B2RPC0_HUMAN KSSLQDHGT-AILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFL B4DRK3_HUMAN B4DRK3_HUMAN KSSLQDHGT-AILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFL CF138_HUMAN CF138_HUMAN KSSLQDHGT-AILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFL PTHD1_DANRE PTHD1_DANRE KISLEEHGA-AILQNTSCFVIGIMPLLFVPSNLTYTLFKCSLLTAGCTVLHCFVILPVFL Q4RF24_TETNG Q4RF24_TETNG KLALEEHGA-AILQNTSCFLMGIMPLVFVPSNLTYTLFKCSLLTAGCTVLHCFVILPVFL Q4S1N7_TETNG Q4S1N7_TETNG RVALERHGVPSSAEPSLCYGAALVPVGSVRSNLTHTLFRCLVLTAGCSALHTLAFLPTLL B1AZU9_MOUSE B1AZU9_MOUSE KNALEVHGV-AILQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVIL PTHD1_MOUSE PTHD1_MOUSE KNALEVHGV-AILQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFTILPVIL B4DQH0_HUMAN B4DQH0_HUMAN KNALEVHGV-AILQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVIL PTHD1_HUMAN PTHD1_HUMAN KNALEVHGV-AILQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVIL MATCH : :*: **. : : .: .:.*: * **** ***:* .* . : :* :.:**.:* CONSENSUS K??L??HG??AILQ???????GL?PL??VPSNLT?TLF?CL?L????T??HCF?ILPV?L

B9EKX1_MOUSE B9EKX1_MOUSE TFFPPSKKHHKKKKRAKRK--------------EREEIECIEIQE-----NPDHVTTV B4DTR9_HUMAN B4DTR9_HUMAN TFFPPSKKHHKKKKRAKRK--------------EREEIECIEIQE-----NPDHVTTV B2RPC0_HUMAN B2RPC0_HUMAN TFFPPSKKHHKKKKRAKRK--------------EREEIECIEIQE-----NPDHVTTV B4DRK3_HUMAN B4DRK3_HUMAN TFFPPSKKHHKKKKRAKRK--------------EREEIECIEIQE-----NPDHVTTV CF138_HUMAN CF138_HUMAN TFFPPSKKHHKKKKRAKRK--------------EREEIECIEIQE-----NPDHVTTV PTHD1_DANRE PTHD1_DANRE TFFPPSKKRHKKKKRAKRK----EREREREREREREEIECIEVRE-----NPDHVTNV Q4RF24_TETNG Q4RF24_TETNG TFFPPSKKRHKKKKRAKRKEREREREREREREREREEIECIEVRE-----NPDHVTNV Q4S1N7_TETNG Q4S1N7_TETNG TFLPPSKTRGHRPEGEG----------------PRQAVECVEMND-GNTRVVDQITTV B1AZU9_MOUSE B1AZU9_MOUSE TFLPPSKKKRKEKKNPE----------------NREEIECVEMVDIDSTRVVDQITTV PTHD1_MOUSE PTHD1_MOUSE TFLPPSKKKRKEKKNPE----------------NREEIECVEMVDIDSTRVVDQITTV B4DQH0_HUMAN B4DQH0_HUMAN TFLPPSKKKRKEKKNPE----------------NREEIECVEMVDIDSTRVVVQITTV PTHD1_HUMAN PTHD1_HUMAN TFLPPSKKKRKEKKNPE----------------NREEIECVEMVDIDSTRVVDQITTV MATCH **:****.: :. : *: :**:*: : ::*.* CONSENSUS TF?PPSKK??K?KK????????????????????REEIEC?E??????????D??TTV


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