Alignment of the gene Family HBG081468 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
INT6_DANRE INT6_DANRE PILLFLIDTSASMNQRTYLGTTYLDIAKGAVEIFMKLRARDPASRGDRYMLVTFDDPPYG B1WAU4_XENTR B1WAU4_XENTR PILLFLIDTSASMNQRTYLGTTYLDIAKGAVEIFMKLRARDPASRGDRYMLVTYDEPPYC DX26B_MOUSE DX26B_MOUSE PILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKLRARDPASRGDRYMLVTYDEPPYC B9EIK3_HUMAN B9EIK3_HUMAN PILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKLRARDPASRGDRYMLVTYDEPPYC DX26B_HUMAN DX26B_HUMAN PILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKLRARDPASRGDRYMLVTYDEPPYC Q4RTK0_TETNG Q4RTK0_TETNG PVLLFLIDTSASMNQRTHLGTTYLDIAKGAVETFIKLRGRDPASRGDRYMLVNFEDVPYG B0UYL7_DANRE B0UYL7_DANRE PVLLFLIDTSASMNQRSHLGTSYLDIAKGAVETFLKLRSRDPASRGDRYMLVSFEEAPAG INT6_MOUSE INT6_MOUSE PILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYA B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN ------------MNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYA INT6_HUMAN INT6_HUMAN PILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYA B3KQH5_HUMAN B3KQH5_HUMAN ------------------------------------------------------------ Q95LX6_MACFA Q95LX6_MACFA ------------------------------------------------------------ Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA PILLFLLDTSASMNQRSHLGTTYLDIAKGAVETFMKLRSRDPASRGDRYMLVTVEEPPYG INT6B_XENLA INT6B_XENLA PILLFLLDTSASMNQRSHLGTTYLDIAKGAVETFMKLRSRDPASRGDRYMLVTLEELPYG MATCH CONSENSUS ????????????????????????????????????????????????????????????

INT6_DANRE INT6_DANRE VK------------------------------------------------------AGWK B1WAU4_XENTR B1WAU4_XENTR IK------------------------------------------------------AGWK DX26B_MOUSE DX26B_MOUSE IK------------------------------------------------------AGWK B9EIK3_HUMAN B9EIK3_HUMAN IK------------------------------------------------------AGWK DX26B_HUMAN DX26B_HUMAN IK------------------------------------------------------AGWK Q4RTK0_TETNG Q4RTK0_TETNG IKVEFCFRVMSGFTLPRSAVRPRLRHALIATSIVSRKIFRRSFHTPFKTWPTFCFNAGWK B0UYL7_DANRE B0UYL7_DANRE IK------------------------------------------------------AGWK INT6_MOUSE INT6_MOUSE IK------------------------------------------------------AGWK B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN IK------------------------------------------------------AGWK INT6_HUMAN INT6_HUMAN IK------------------------------------------------------AGWK B3KQH5_HUMAN B3KQH5_HUMAN ------------------------------------------------------------ Q95LX6_MACFA Q95LX6_MACFA ------------------------------------------------------------ Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA IK------------------------------------------------------AGWK INT6B_XENLA INT6B_XENLA IK------------------------------------------------------AGWK MATCH CONSENSUS ????????????????????????????????????????????????????????????

INT6_DANRE INT6_DANRE ENHATFMSELKNLQASGLTTLGHALRAAFDLLNLNRLVSGIDNYGQ-------------- B1WAU4_XENTR B1WAU4_XENTR ENHATFMNELKNLQASGLTTLGQALRSSFDLLNLNRLVSGIDNYGQ-------------- DX26B_MOUSE DX26B_MOUSE ENHATFMNELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQ-------------- B9EIK3_HUMAN B9EIK3_HUMAN ENHATFMSELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQ-------------- DX26B_HUMAN DX26B_HUMAN ENHATFMSELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQ-------------- Q4RTK0_TETNG Q4RTK0_TETNG ESHATFMTELRNLQATGLTTIGQSLRNAFDLLNLNRLVTGIDNYGQKKTDRWVLLECQVS B0UYL7_DANRE B0UYL7_DANRE DSHATFMTELRNLQAVGLTSFGQALRTAFDLLNLNRLVSGIDNYGQ-------------- INT6_MOUSE INT6_MOUSE ENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQ-------------- B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN ENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQ-------------- INT6_HUMAN INT6_HUMAN ENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQ-------------- B3KQH5_HUMAN B3KQH5_HUMAN ------------------------------------------------------------ Q95LX6_MACFA Q95LX6_MACFA ------------------------------------------------------------ Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA ENHATFMNELKNLQAVGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQ-------------- INT6B_XENLA INT6B_XENLA ENHATFMNELKNLQAVGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQ-------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

INT6_DANRE INT6_DANRE --------GRNPFFLEPSVIITITDGNKLTHSSGVAEELHLPLNSPLPGSELTKEPFRWD B1WAU4_XENTR B1WAU4_XENTR --------GRNPFFLEPSILITITDGNKLTSTASVQEELHLPLNSPLPGSELTKEPFRWD DX26B_MOUSE DX26B_MOUSE --------GRNPFFLEPSILITITDGNKLTSTASVQEELHLPLNSPLPGSELTKEPFRWD B9EIK3_HUMAN B9EIK3_HUMAN --------GRNPFFLEPSILITITDGNKLTSTAGVQEELHLPLNSPLPGSELTKEPFRWD DX26B_HUMAN DX26B_HUMAN --------GRNPFFLEPSILITITDGNKLTSTAGVQEELHLPLNSPLPGSELTKEPFRWD Q4RTK0_TETNG Q4RTK0_TETNG EGSSGSPPGRNPFFLEPAIIIAISDGNKLTSGSGVQEELHLPLTTPLPGSELTKEPFRWD B0UYL7_DANRE B0UYL7_DANRE --------GRNPFFLEPAIIVAITDGSKLTGSSGVQDELHLPLTTPLPGSELTKEPFRWD INT6_MOUSE INT6_MOUSE --------GRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWD B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN --------GRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWD INT6_HUMAN INT6_HUMAN --------GRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWD B3KQH5_HUMAN B3KQH5_HUMAN ------------------------------------------------------------ Q95LX6_MACFA Q95LX6_MACFA ------------------------------------------------------------ Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA --------GRNPFFLEPSIIIVITDGSKLTTANGVQDELHLPLYSPLPGSELTKEPFRWD INT6B_XENLA INT6B_XENLA --------GRNPFFLEPSIIVAITDGSKLTTANGVQDELHLPLNSPLPGSELTKEPFRWD MATCH CONSENSUS ????????????????????????????????????????????????????????????

INT6_DANRE INT6_DANRE QRLFALVLRLPGVAVPDSEQLGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQ B1WAU4_XENTR B1WAU4_XENTR QRLFALVLRLPGASSVEPEQVGGVPSDDSAISQMCEVTGGRSYCVRTQRMLNQCLESLVQ DX26B_MOUSE DX26B_MOUSE QRLFALVLRLPGVASTEPEQLGSVPSDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQ B9EIK3_HUMAN B9EIK3_HUMAN QRLFALVLRLPGVASTEPEQLGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQ DX26B_HUMAN DX26B_HUMAN QRLFALVLRLPGVASTEPEQLGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQ Q4RTK0_TETNG Q4RTK0_TETNG QRLFALVLRIPGNASVEPEPVGGVPPDDSPITPMCEVTGGRSYSVFSQRTLNQCLESLVQ B0UYL7_DANRE B0UYL7_DANRE QRLFSLVLRVPGHASADPEPVGGVPLDSSPITPMCEVTGGRSYSVFSQRMLNQCLESLVQ INT6_MOUSE INT6_MOUSE QRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQ B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN QRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQ INT6_HUMAN INT6_HUMAN QRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQ B3KQH5_HUMAN B3KQH5_HUMAN -------------MSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQ Q95LX6_MACFA Q95LX6_MACFA ------------------------------------------------------------ Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA QRLFALVLRLPGASLVEQEQPPAVQFDESPITAMCDVTGGRSYSVTSQRILNQCLESLVQ INT6B_XENLA INT6B_XENLA QRLFALVLRLPGATAVEQEQPTAVQFDESPITAMCDVTGGRSYSVTSQRILNQCLESLVQ MATCH CONSENSUS ??????????????????E????V??D?S?I??MC?VTGGRSY?V???R?LNQCLESLVQ

INT6_DANRE INT6_DANRE KVLSGVVIHFEKTGPDPPVIGEDGLVDPARPLTSFSPQPWHSCHKLIYVRPNPKTGVPVG B1WAU4_XENTR B1WAU4_XENTR KVQSGVVINFEKTGPDPTPNSEDGLADSLRPTHSFAPQAWHTCHKLIYVRPNPKTGVPVG DX26B_MOUSE DX26B_MOUSE KVQSGVVINFEKTGPDPLPVGEDTLMELCRPSNLFAAQPWHSCHKLIYVRPNSKTGVPVG B9EIK3_HUMAN B9EIK3_HUMAN KVQSGVVINFEKTGPDPLPIGEDGLMDSSRPSNSFAAQPWHSCHKLIYVRPNSKTGVPVG DX26B_HUMAN DX26B_HUMAN KVQSGVVINFEKTGPDPLPIGEDGLMDSSRPSNSFAAQPWHSCHKLIYVRPNSKTGVPVG Q4RTK0_TETNG Q4RTK0_TETNG KIQSGVVIKFEKTGPDPPPL-EDAPAEAQKS----GVQPWHCCHKLIYVRPNPKTGVPIG B0UYL7_DANRE B0UYL7_DANRE KIQSGVVINFEKTGPDPSPT-EDGPIEVKH-----GPQVWHSCHKLIYVRPNPKTGVPVG INT6_MOUSE INT6_MOUSE KVQSGVVINFEKAGPDPPPA-EEGQPDISRP---FGSQPWHSCHKLIYVRPNPKTGVPIG B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN KVQSGVVINFEKAGPDPSPV-EDGQPDISRP---FGSQPWHSCHKLIYVRPNPKTGVPIG INT6_HUMAN INT6_HUMAN KVQSGVVINFEKAGPDPSPV-EDGQPDISRP---FGSQPWHSCHKLIYVRPNPKTGVPIG B3KQH5_HUMAN B3KQH5_HUMAN KVQSGVVINFEKAGPDPSPV-EDGQPDISRP---FGSQPWHSCHKLIYVRPNPKTGVPIG Q95LX6_MACFA Q95LX6_MACFA ------------------------------------------------------------ Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA KVQSGVVIHFEKSGPDP-PILEDGLTDPVRS---VGSQPWHNCHKLIYVRPNPKTGVPLG INT6B_XENLA INT6B_XENLA KIQSGVVINFEKSGPDP-PILEDGLTDPVRS---VGSQPWHSCHKLIYVRPNPKTGVPIG MATCH CONSENSUS K??SGVVI?FEK?GPDP????E???????????????Q?WH?CHKLIYVRPN?KTGVP?G

INT6_DANRE INT6_DANRE HWPISESFWPDQNSPTLPPRSAHPVVRFSCVDCEPMVIDKLPFDKYELEPSPLTQYILER B1WAU4_XENTR B1WAU4_XENTR HWPIPESFWPDQNSPTLPPRTAHPVVRFSCLDCEPMVIDKLPFDKYELEPSPLTQFILER DX26B_MOUSE DX26B_MOUSE HWPIPESFWPEQNLPSLPPRTSHPVVRFSCVDCEPMVIDKLPFDKYELEPSPLTQYILER B9EIK3_HUMAN B9EIK3_HUMAN HWPIPESFWPDQNLPSLPPRTSHPVVRFSCVDCEPMVIDKLPFDKYELEPSPLTQYILER DX26B_HUMAN DX26B_HUMAN HWPIPESFWPDQNLPSLPPRTSHPVVRFSCVDCEPMVIDKLPFDKYELEPSPLTQYILER Q4RTK0_TETNG Q4RTK0_TETNG HWPIPEAFWPDQNSPTLPPRSAHPHVRFSCLDAEPMVIDKVPFDKYELEPSPLTQYILER B0UYL7_DANRE B0UYL7_DANRE HWPIPESFWPDQNSPTLPPRAAHPHVKFSCVDSEPMVVDKVPFDKYELEPSPLTQYILER INT6_MOUSE INT6_MOUSE HWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILER B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN HWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILER INT6_HUMAN INT6_HUMAN HWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILER B3KQH5_HUMAN B3KQH5_HUMAN HWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILER Q95LX6_MACFA Q95LX6_MACFA -----------------------------------MVIDKLPFDKYELEPSPLTQFILER Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA HWPIPESFWPDQNSPTLPPRTSHPVVKFSCTDSEPMIIDKLPFDKYELEPSPLTQFILER INT6B_XENLA INT6B_XENLA HWPIPESFWPDQNSPTLPPRTSHPVVKFSCTDSEPLVIDKLPFDKYELEPSPLTQFILER MATCH CONSENSUS HWP??E?FWP?QN?P?LPPR??HP?V?FSC?D?EPMVIDK?PFDKYELEPSPLTQ?ILER

INT6_DANRE INT6_DANRE KSPHMCWQVFVNCSGKHSDVAHPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHK B1WAU4_XENTR B1WAU4_XENTR KSPHTCWQVFVNSSGKYSEIGQPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHK DX26B_MOUSE DX26B_MOUSE KSPHTCWQVFVTSSSKYNELGYPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHK B9EIK3_HUMAN B9EIK3_HUMAN KSPHTCWQVFVTSSGKYNELGYPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHK DX26B_HUMAN DX26B_HUMAN KSPHTCWQVFVTSSGKYNELGYPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHK Q4RTK0_TETNG Q4RTK0_TETNG KSPHTCWQVFVCNSAKYSDLGQPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLIKVHK B0UYL7_DANRE B0UYL7_DANRE KSPHTCWQVFVCNSAKYGELGQPFGYLKASTALNCVNLFVMPYNYPVVLPLLDDLIVVHK INT6_MOUSE INT6_MOUSE KSPQTCWQVYVSNSAKYNELGHPFGYLKASTALTCVNLFVMPYNYPVLLPLLDDLFKVHK B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------------------------------ A8MV98_HUMAN A8MV98_HUMAN KSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHK INT6_HUMAN INT6_HUMAN KSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHK B3KQH5_HUMAN B3KQH5_HUMAN KSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHK Q95LX6_MACFA Q95LX6_MACFA KSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHK Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA KSPHSCWPVFVANSAKYSELGHPFGYLKASTALNCVNLFVLPYNYPVFLPLLDDLFKIHK INT6B_XENLA INT6B_XENLA KSPHTCWPVFVPNSAKYCELGHPFGYLKASTALNCVNLFVLPYNYPVLLPLLDDLFKMHK MATCH CONSENSUS KSP??CW?V?V??S?KY???G?PFGYLKAST?L?CVNLFV?PYNYPV?LPLLDDL?K?HK

INT6_DANRE INT6_DANRE LKPNLKWRQSFEMYLKSMPPYYLLPLKKALRMMGAPNLISDNMDCGLSYSVISYLKKLSQ B1WAU4_XENTR B1WAU4_XENTR LKPTLKWRQTFDNYLKTMPPYFLMPLKKALRMMGAPNLISENLDCGLSYSVISYLKKLSQ DX26B_MOUSE DX26B_MOUSE LKPNLKWRQAFDSYLKTLPPYYL------------------------------------- B9EIK3_HUMAN B9EIK3_HUMAN LKPNLKWRQAFDSYLKTLPPYYL------------------------------------- DX26B_HUMAN DX26B_HUMAN LKPNLKWRQAFDSYLKTLPPYYL------------------------------------- Q4RTK0_TETNG Q4RTK0_TETNG FKPTLKWRQSFENYLKTMPPYYIGSLRKALRIMGAPNLLADNMEYGLSYSVVSYLKKLSQ B0UYL7_DANRE B0UYL7_DANRE FKPPVKWRQSFENYLKTMPPYYIPALRKALRMMGAPNLLADNMEYGLSYSVVSYLKKLSQ INT6_MOUSE INT6_MOUSE AKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQ B4E2C8_HUMAN B4E2C8_HUMAN -------------------------------MMGAPNLIADSMEYGLSYSVISYLKKLSQ A8MV98_HUMAN A8MV98_HUMAN AKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQ INT6_HUMAN INT6_HUMAN AKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQ B3KQH5_HUMAN B3KQH5_HUMAN AKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQ Q95LX6_MACFA Q95LX6_MACFA AKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQ Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA NKPSLKWRQLFENYLKTMPPYYIGPLKKALRMMGAPNLMPDSMEYGLSYSVVSYLKKLSQ INT6B_XENLA INT6B_XENLA NKPPLKWRQPFENYLKTMPPYYIGPLKKALRMMGTPNLMPDSMEYGLSYSVVSYLKKLSQ MATCH CONSENSUS ?KP?LKWRQ?F??YLKT?PPYY??????????????????????????????????????

INT6_DANRE INT6_DANRE ------------------------------------QAKIESDRLIVSVGKKPPPETGIK B1WAU4_XENTR B1WAU4_XENTR ------------------------------------QTKIESERIIASVGKKAPQETGIK DX26B_MOUSE DX26B_MOUSE ------------------------------------ITKLESDQILASVGKKPPQEIGIK B9EIK3_HUMAN B9EIK3_HUMAN ------------------------------------LTKLESERILASVGKKPPQEIGIK DX26B_HUMAN DX26B_HUMAN ------------------------------------LTKLESERILASVGKKPPQEIGIK Q4RTK0_TETNG Q4RTK0_TETNG QVGTSASVRRDEAFGAVFICQKQSKYDNSAGLFHLLQSKIEYDRLISSIGKKLPAEAGIK B0UYL7_DANRE B0UYL7_DANRE ------------------------------------QAKIEADRVCASVGKKVAPEGGIK INT6_MOUSE INT6_MOUSE ------------------------------------QAKIESDRVIGSVGKKVVQETGIK B4E2C8_HUMAN B4E2C8_HUMAN ------------------------------------QAKIESDRVIGSVGKKVVQETGIK A8MV98_HUMAN A8MV98_HUMAN ------------------------------------QAKIESDRVIGSVGKKVVQETGIK INT6_HUMAN INT6_HUMAN ------------------------------------QAKIESDRVIGSVGKKVVQETGIK B3KQH5_HUMAN B3KQH5_HUMAN ------------------------------------QAKIESDRVIGSVGKKVVQETGIK Q95LX6_MACFA Q95LX6_MACFA ------------------------------------QAKIESDRVIGSVGKKVVQETGIK Q4R5Z8_MACFA Q4R5Z8_MACFA ------------------------------------------------------------ INT6A_XENLA INT6A_XENLA ------------------------------------QAKVESDRVIGSIGKKFPQETGIK INT6B_XENLA INT6B_XENLA ------------------------------------QAKVESDRVIGSIGKKYPQETSIK MATCH CONSENSUS ??????????????????????????????????????K?ES?R???S?GKK???E?GIK

INT6_DANRE INT6_DANRE VKNHSN-ALSLAHRRDFKQLLQGITGEVPLRLIDMNFKEFAGFQIALLNK---------- B1WAU4_XENTR B1WAU4_XENTR VKNNST-RLSLVHNRDFKQLLQGFCNESSIRVSEINVKEFPGFQVGLLNK---------- DX26B_MOUSE DX26B_MOUSE VKNHSACGLPLAHNKSFRKLLKEIIGESAPRLTELNPKEFAGFQVGLLNK---------- B9EIK3_HUMAN B9EIK3_HUMAN VKNHSGGGMSLTHNKNFRKLLKEITGETALRLTELNTKEFAGFQIGLLNK---------- DX26B_HUMAN DX26B_HUMAN VKNHSGGGMSLTHNKNFRKLLKEITGETALRLTELNTKEFAGFQIGLLNK---------- Q4RTK0_TETNG Q4RTK0_TETNG VRWRGG-GISLAQRRDFIQQLQSLTGDGPSLPLELNPKEFQGFHLAMLNKVSGPAGKGPP B0UYL7_DANRE B0UYL7_DANRE LRCRSS-ALSLANRKDFTQLLQSIMGDGPALPMEANTKEFAGFQLASLNK---------- INT6_MOUSE INT6_MOUSE VRSRSH-GLSMAHRKGF-QVLQGISEDVPHRLLDLNMKEYTGFQVALLNK---------- B4E2C8_HUMAN B4E2C8_HUMAN VRSRSH-GLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNK---------- A8MV98_HUMAN A8MV98_HUMAN VRSRSH-GLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNK---------- INT6_HUMAN INT6_HUMAN VRSRSH-GLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNK---------- B3KQH5_HUMAN B3KQH5_HUMAN VRSRSH-GLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNK---------- Q95LX6_MACFA Q95LX6_MACFA VRSRSH-GLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNK---------- Q4R5Z8_MACFA Q4R5Z8_MACFA ----------MAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNK---------- INT6A_XENLA INT6A_XENLA VRSGSN-ALSLALRKDFKQLLQEITGEVPQRPMDLNMKEFAGFQIALLNK---------- INT6B_XENLA INT6B_XENLA VRSGSN-ALSLALRKDFKQLLQEITGEVPQRPMDLNMKEFAGFQIALLNK---------- MATCH :. .:.* : *: : : . : * **: **::. *** CONSENSUS V???S????S?A??K?F?QLLQ?I??????R???LN?KE??GFQ??LLNK??????????

INT6_DANRE INT6_DANRE ----------------DLKPQAYRNAYDIPRRNLLDQVTRMRSNLLRTTQKLIRGQDD-- B1WAU4_XENTR B1WAU4_XENTR ----------------DLKPQTYRNAYDIPRRNLLDQLTRMRTNLLK-THKLIVGQDE-- DX26B_MOUSE DX26B_MOUSE ----------------DLKPQTYRNAYDIPRRGLLDQLTRMRSNLLQ-TRKFIVGQDE-- B9EIK3_HUMAN B9EIK3_HUMAN ----------------DLKPQTYRNAYDIPRRGLLDQLTRMRSNLLK-THKFIVGQDE-- DX26B_HUMAN DX26B_HUMAN ----------------DLKPQTYRNAYDIPRRGLLDQLTRMRSNLLK-THKFIVGQDE-- Q4RTK0_TETNG Q4RTK0_TETNG PPVSEGKKTHLFCLCQGLKPQSFRNPYDIPRSHLLDQLSRMRRNLLNTSVCTLRGQDSGR B0UYL7_DANRE B0UYL7_DANRE ----------------ALKPQGLRNPYDIPRAHLLDQLSRMRRNLLHASICILKGQDQ-- INT6_MOUSE INT6_MOUSE ----------------DLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRKFLKGQDE-- B4E2C8_HUMAN B4E2C8_HUMAN ----------------DLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDE-- A8MV98_HUMAN A8MV98_HUMAN ----------------DLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDE-- INT6_HUMAN INT6_HUMAN ----------------DLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDE-- B3KQH5_HUMAN B3KQH5_HUMAN ----------------DLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDE-- Q95LX6_MACFA Q95LX6_MACFA ----------------DLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDE-- Q4R5Z8_MACFA Q4R5Z8_MACFA ----------------DLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDE-- INT6A_XENLA INT6A_XENLA ----------------DIKPQTFRNAYDVPRTNLLDHLTRMRVNLLRSTRQFLKGQDE-- INT6B_XENLA INT6B_XENLA ----------------DIKPQTFRNAYDIPRTNLLDHLTRMRANLLKSTRQFLKGQDE-- MATCH :*** **.**:** ***:::*** ***. : : ***. CONSENSUS ????????????????DLKPQT?RNAYDIPR??LLD?LTRMR?NLL??T?????GQDE??

INT6_DANRE INT6_DANRE ---------------------DSLHSIPVGQMGNYQEYLKMMPSPLREIDPDQPKRLHTF B1WAU4_XENTR B1WAU4_XENTR ---------------------DCLHSVPVAQMGNYQEYLKSMPSPLREIDPDQPKRLHTF DX26B_MOUSE DX26B_MOUSE ---------------------DSLHSVPVAQMGNYQEYLKMLASPLRELDPDQPKRLHTF B9EIK3_HUMAN B9EIK3_HUMAN ---------------------DSFHSVPVAQMGNYQEYLKTLASPLREIDPDQPKRLHTF DX26B_HUMAN DX26B_HUMAN ---------------------DSLHSVPVAQMGNYQEYLKTLASPLREIDPDQPKRLHTF Q4RTK0_TETNG Q4RTK0_TETNG SPPGGLPPSSSSPLMRLGASPDQLHSVPIAQMGNYQDFLKSAPQPLRDADPEQPKRLHTF B0UYL7_DANRE B0UYL7_DANRE ---------------------DQLHSVPIAQMGNYQDFLKHCPSPLREADPDQPKRLHTF INT6_MOUSE INT6_MOUSE ---------------------DQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTF B4E2C8_HUMAN B4E2C8_HUMAN ---------------------DQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTF A8MV98_HUMAN A8MV98_HUMAN ---------------------DQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTF INT6_HUMAN INT6_HUMAN ---------------------DQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTF B3KQH5_HUMAN B3KQH5_HUMAN ---------------------DQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTF Q95LX6_MACFA Q95LX6_MACFA ---------------------DQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTF Q4R5Z8_MACFA Q4R5Z8_MACFA ---------------------DQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTF INT6A_XENLA INT6A_XENLA ---------------------DQAHSIPIVQMGNYQEFLKHIPSPLRELDYDQPRRLHTF INT6B_XENLA INT6B_XENLA ---------------------DQAHSIPIVQMGNYQEYLKHIPSPLRELDYDQPRRLHTF MATCH * **:*: ******::** ..***: * :**:***** CONSENSUS ?????????????????????D??HSVP?AQMGNYQEYLK??PSPLRE?DPDQP?RLHTF

INT6_DANRE INT6_DANRE GNPFKQDKK-----------------GMMIDEADEFVTGPQNKKRGNTGD---LNSGTAL B1WAU4_XENTR B1WAU4_XENTR GNPFKQDKK-----------------GMMIDEADEFVAGPQNKIK-RPGE---LNTPASL DX26B_MOUSE DX26B_MOUSE GNPFKQDKK-----------------GMMIDEADEFVVGPQNKVK-RPGE---PNSPMSS B9EIK3_HUMAN B9EIK3_HUMAN GNPFKQDKK-----------------GMMIDEADEFVAGPQNKVK-RPGE---PNSPMSS DX26B_HUMAN DX26B_HUMAN GNPFKQDKK-----------------GMMIDEADEFVAGPQNKVK-RPGE---PNSPMSS Q4RTK0_TETNG Q4RTK0_TETNG GNPFKLDKKASLGEPSGPPAGGCGLQGMMIDEADEFVTGPQSKGK-RPGDSSNNTGGGGP B0UYL7_DANRE B0UYL7_DANRE GNPFKLDKK-----------------AMMVDEADEFVTGTQGKGK-RPGESSSPTVGGAP INT6_MOUSE INT6_MOUSE GNPFKLDKK-----------------GMMIDEADEFVAGPQNKHK-RPGE---PSMQGIP B4E2C8_HUMAN B4E2C8_HUMAN GNPFRLDKK-----------------GMMIDEADEFVAGPQNKHK-RPGE---PNMQGIP A8MV98_HUMAN A8MV98_HUMAN GNPFKLDKK-----------------GMMIDEADEFVAGPQNKHK-RPGE---PNMQGIP INT6_HUMAN INT6_HUMAN GNPFKLDKK-----------------GMMIDEADEFVAGPQNKHK-RPGE---PNMQGIP B3KQH5_HUMAN B3KQH5_HUMAN GNPFKLDKK-----------------GMMIDEADEFVAGPQNKHK-RPGE---PNMQGIP Q95LX6_MACFA Q95LX6_MACFA GNPFKLDKK-----------------GMMIDEADEFVAGPQNKHK-RPGE---PNMQGIP Q4R5Z8_MACFA Q4R5Z8_MACFA GNPFKLDKK-----------------GMMIDEADEFVAGPQNKHK-RPGE---PNMQGIP INT6A_XENLA INT6A_XENLA GNPFKLDKK-----------------GMMIDEADEFVSGNQNKHK-RTGE---PNMQGVP INT6B_XENLA INT6B_XENLA GNPFKLDKK-----------------GMMIDEADEFVSGNQNKLK-RTGE---PNMQGVP MATCH ****: *** .**:******* * *.* : ..*: . CONSENSUS GNPFK?DKK?????????????????GMMIDEADEFV?GPQNK?K?RPGE???PN?????

INT6_DANRE INT6_DANRE KRRRSMSPLLR--RPQTPPIITNHVLGKGPTGT--------------------------- B1WAU4_XENTR B1WAU4_XENTR KRRRSMSPLLL-RRPQTPPIITNHVGGKGPPTSPGG------------------------ DX26B_MOUSE DX26B_MOUSE KRRRSMSLLLR--RAQTAPTVTNHVGGKGPLSASWF------------------------ B9EIK3_HUMAN B9EIK3_HUMAN KRRRSMSLLLR--KPQTPPTVTNHVGGKGPPSASWF------------------------ DX26B_HUMAN DX26B_HUMAN KRRRSMSLLLR--KPQTPPTVTNHVGGKGPPSASWF------------------------ Q4RTK0_TETNG Q4RTK0_TETNG KRRRCMSPLLRLGRAYTPPVSPPA-----SPRPAAGGVGSGWGRNASARESGAKCPLCRR B0UYL7_DANRE B0UYL7_DANRE KRRRCMSPLLRPGRAYTPPRT--------PSRTPD------------------------- INT6_MOUSE INT6_MOUSE KRRRCASPLLR-GRRQSP-AVNSHIGGKGPPAPMT------------------------- B4E2C8_HUMAN B4E2C8_HUMAN KRRRCMSPLLR-GRQQNP-VVNNHIGGKGPPAPTT------------------------- A8MV98_HUMAN A8MV98_HUMAN KRRRCMSPLLR-GRQQNP-VVNNHIGGKGPPAPTT------------------------- INT6_HUMAN INT6_HUMAN KRRRCMSPLLR-GRQQNP-VVNNHIGGKGPPAPTT------------------------- B3KQH5_HUMAN B3KQH5_HUMAN KRRRCMSPLLR-GRQQNP-VVNNHIGGKGPPAPTT------------------------- Q95LX6_MACFA Q95LX6_MACFA KRRRCMSPLLR-GRQQNP-VVNNHIGGKGPPAPTT------------------------- Q4R5Z8_MACFA Q4R5Z8_MACFA KRRRCMSPLLR-GRQQNP-VVNNHIGGKGPPAPTT------------------------- INT6A_XENLA INT6A_XENLA KRRRCMSPLLR-SRPQSPAVINNHIGGKDPPISVN------------------------- INT6B_XENLA INT6B_XENLA KRRRCMSPLLH-SRPQSPSVINNHISGKDSPVSVN------------------------- MATCH ****. * ** : .. . . CONSENSUS KRRR?MSPLLR??R?Q?P????NH??GK?PP?????????????????????????????

INT6_DANRE INT6_DANRE -----------QGQQGIIKPIPLHKGAE--GNNVGGTES-------NGERVAGTDAGDCW B1WAU4_XENTR B1WAU4_XENTR -----------SITHNLIKPIPVHKDTNNVLTAEGNGERLDNGQ--PLEKQMDGLPPLIV DX26B_MOUSE DX26B_MOUSE -----------PSCPSLVKHTFGHPDTT--VIHDTHEEKMENGQSPPDGFLLKSAPAEFM B9EIK3_HUMAN B9EIK3_HUMAN -----------PSYPNLIKPTLVHTDAT--IIHDGHEEKMENGQITPDGFLSKSAPSELI DX26B_HUMAN DX26B_HUMAN -----------PSYPNLIKPTLVHTDAT--IIHDGHEEKMENGQITPDGFLSKSAPSELI Q4RTK0_TETNG Q4RTK0_TETNG GLERQLARVRPDGQPPDPEPLRRRRRPG--LGGGPLLGPR-RPPGEPRGGRRREAPGRAG B0UYL7_DANRE B0UYL7_DANRE -----------NNHLELENHITNHLEPN--CDSDSDINPV------PESEVIQQ------ INT6_MOUSE INT6_MOUSE -----------QAQPGLIKPLPLHKEAT----NDSIVDDV------VENHVADQLSSDMT B4E2C8_HUMAN B4E2C8_HUMAN -----------QAQPDLIKPLPLHKISE--TTNDSIIHDV------VENHVADQLSSDIT A8MV98_HUMAN A8MV98_HUMAN -----------QAQPDLIKPLPLHKISE--TTNDSIIHDV------VENHVADQLSSDIT INT6_HUMAN INT6_HUMAN -----------QAQPDLIKPLPLHKISE--TTNDSIIHDV------VENHVADQLSSDIT B3KQH5_HUMAN B3KQH5_HUMAN -----------QAQPDLIKPLPLHKISE--TTNDSIIHDV------VENHVADQLSSDIT Q95LX6_MACFA Q95LX6_MACFA -----------QAQPDLIKPLPLHKISE--TTNDSIIHDV------VENHVADQLSSDIT Q4R5Z8_MACFA Q4R5Z8_MACFA -----------QAQPDLIKPLPLHKISE--TTNDSIIHDV------VENHVADQLSSDIT INT6A_XENLA INT6A_XENLA -----------QVSPDLPKPVAVHKNTD--LSNNATVNEA------TENHVADHFCDDLL INT6B_XENLA INT6B_XENLA -----------QVLCDLPKPVAVHKNTD--MSNNVAINEA------TENHVADHLCDDLL MATCH : : . CONSENSUS ????????????????L?KP???H????????????????????????????????????

INT6_DANRE INT6_DANRE PGEVDGESGEPAP---VEDREDAAAPDGEEEILALENCLDDRSPDHTQNCEELSPPGQEG B1WAU4_XENTR B1WAU4_XENTR SSALDDEVVVSNDFHTVTDELNCFSDDGLEQKPVNN--VKGPSDNYMPAEESG-----DV DX26B_MOUSE DX26B_MOUSE N--VSGESFISSQLDSLSDDFTGLRKDGFIHKPGNNILLGGAKTCSLSVADQK-----IT B9EIK3_HUMAN B9EIK3_HUMAN N--MTGDLMPPNQVDSLSDDFTSLSKDGLIQKPGSNAFVGGAKNCSLSVDDQK-----DP DX26B_HUMAN DX26B_HUMAN N--MTGDLMPPNQVDSLSDDFTSLSKDGLIQKPGSNAFVGGAKNCSLSVDDQK-----DP Q4RTK0_TETNG Q4RTK0_TETNG ERAGAGGRAPAGPRGGRGGPAGGGAP--------GPLPVGRLAEAAHPHRDHQGEQRAPS B0UYL7_DANRE B0UYL7_DANRE --------SNHLQTEEVENQQDCVQENG--QSSDSELSLGSEGEEEAPHRYQY-----PC INT6_MOUSE INT6_MOUSE PNAMDTEFLTSPP-NLLEPSTNHTEALGHEHLGNNDLTVGGFLENHEEPRNKE-----QS B4E2C8_HUMAN B4E2C8_HUMAN PNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKE-----QC A8MV98_HUMAN A8MV98_HUMAN PNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKE-----QC INT6_HUMAN INT6_HUMAN PNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKE-----QC B3KQH5_HUMAN B3KQH5_HUMAN PNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKE-----QC Q95LX6_MACFA Q95LX6_MACFA PNAMDTEFSTSSPAGLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKE-----QC Q4R5Z8_MACFA Q4R5Z8_MACFA PNAMDTEFSTSSPAGLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKE-----QC INT6A_XENLA INT6A_XENLA I--TKSEPFGTLSSAALEATEGYAAEKDSNFRPNDISDV--FLENTKETGDNE-----SC INT6B_XENLA INT6B_XENLA I--TKSESFGTLPNAALEASESYAAGGDSNFSPNDTSDV--LLDKTRESGDTE-----SC MATCH : CONSENSUS ???????????????????????????G??????????V?????????????????????

INT6_DANRE INT6_DANRE EMEVNEGDTPAQGTIVMIP--LEGSNAELRTRVIKEVRKPGRNYE--------------A B1WAU4_XENTR B1WAU4_XENTR QECTSGSCVPNTLK--RVHSMIEGSNADIKIKVMKEVRKPGRNYE--------------K DX26B_MOUSE DX26B_MOUSE MASALET-VPNSMQ--ITPAMAQGINADIKHQLMKEVRKFGRKYE--------------R B9EIK3_HUMAN B9EIK3_HUMAN VASTLGA-MPNTLQ--ITPAMAQGINADIKHQLMKEVRKFGRKYE--------------R DX26B_HUMAN DX26B_HUMAN VASTLGA-MPNTLQ--ITPAMAQGINADIKHQLMKEVRKFGRKYE--------------R Q4RTK0_TETNG Q4RTK0_TETNG AHHQGDQETRQALREDLPPPEADPGNPGHAAHLPPEHHQRGSQVGPEPSVGGRVGWARPR B0UYL7_DANRE B0UYL7_DANRE QLKK------------IRNQESQELNSELRVLITKEIRKPGRRYE--------------K INT6_MOUSE INT6_MOUSE AEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYE--------------R B4E2C8_HUMAN B4E2C8_HUMAN AEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYE--------------R A8MV98_HUMAN A8MV98_HUMAN AEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYE--------------R INT6_HUMAN INT6_HUMAN AEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYE--------------R B3KQH5_HUMAN B3KQH5_HUMAN AEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYE--------------R Q95LX6_MACFA Q95LX6_MACFA AEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYE--------------R Q4R5Z8_MACFA Q4R5Z8_MACFA AEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYE--------------R INT6A_XENLA INT6A_XENLA LPNNNAA-FTHRKRRLQQCRSYEEANIELKAQILKEIRKPGRKYG--------------I INT6B_XENLA INT6B_XENLA LLNNNTA-FVHRKRRLHQCRSYEEANIELKAQILKEIRKPGRKYG--------------I MATCH : * : * :: * . CONSENSUS ?????????????????????????N???K????KE?RK?GR?YE???????????????

INT6_DANRE INT6_DANRE I------FRLLEEVKGPVSVQRYFIHHAIKEAA------------RFKKRMLIQQLETAL B1WAU4_XENTR B1WAU4_XENTR I------FTLLEEVQGSPEVQKTFIEFTIKEAA------------RFKKRVLIQHLERVL DX26B_MOUSE DX26B_MOUSE I------FILLEEVQGPLETKKQFVEFTIKEAA------------RFKRRVLIQYLEKVL B9EIK3_HUMAN B9EIK3_HUMAN I------FILLEEVQGPLEMKKQFVEFTIKEAA------------RFKRRVLIQYLEKVL DX26B_HUMAN DX26B_HUMAN I------FILLEEVQGPLEMKKQFVEFTIKEAA------------RFKRRVLIQYLEKVL Q4RTK0_TETNG Q4RTK0_TETNG VTHPPLPFAGSRSASSSSSWRTSWRRFTAEPTTSTTWTRSENTSPRPSLLLALRPLRGLP B0UYL7_DANRE B0UYL7_DANRE I------FYLLKQIQGSLETRLIFLQSIIKEAA------------RFKKRVLIEQLEIFI INT6_MOUSE INT6_MOUSE I------FTLLKHVQGSLQTRLIFLQNVIKEAS------------RFKKRMLIEQLENFL B4E2C8_HUMAN B4E2C8_HUMAN I------FTLLKHVQGSLQTRLIFLQNVIKEAS------------RFKKRMLIEQLENFL A8MV98_HUMAN A8MV98_HUMAN I------FTLLKHVQGSLQTRLIFLQNVIKEAS------------RFKKRMLIEQLENFL INT6_HUMAN INT6_HUMAN I------FTLLKHVQGSLQTRLIFLQNVIKEAS------------RFKKRMLIEQLENFL B3KQH5_HUMAN B3KQH5_HUMAN I------FTLLKHVQGSLQTRLIFLQNVIKEAS------------RFKKRMLIEQLENFL Q95LX6_MACFA Q95LX6_MACFA I------FTLLKHVQGSLQTRLIFLQNVIKEAS------------RFKKRMLIEQLENFL Q4R5Z8_MACFA Q4R5Z8_MACFA I------FTLLKHVQGSLQTRLIFLQNVIKEAS------------RFKKRMLIEQLENFL INT6A_XENLA INT6A_XENLA I------FTLLKDVQGDLQTRLLFLQNVIQEAA------------RFKKRNLIEQLEGFL INT6B_XENLA INT6B_XENLA I------FTLLKDVQGDLQTRLLFLQHVIKEAT------------RFKKRMLIEQLEGFL MATCH : * . .. . : : . : :: * . :. *. CONSENSUS I??????F?LL??VQG?L?????F????IKEA?????????????RFK?R?LI??LE??L

INT6_DANRE INT6_DANRE EEIEDRQMLPAQINNIHSR--- B1WAU4_XENTR B1WAU4_XENTR SNVDYSG-LPNSLNHINSR--- DX26B_MOUSE DX26B_MOUSE EKIDSHH-LLNNVNHINSRSSC B9EIK3_HUMAN B9EIK3_HUMAN EKINSHH-LHNNISHINSRSSC DX26B_HUMAN DX26B_HUMAN EKINSHH-LHNNISHINSRSSC Q4RTK0_TETNG Q4RTK0_TETNG GACWKHS---YLLLR------- B0UYL7_DANRE B0UYL7_DANRE EEIHLRA---NGMNHLDSF--- INT6_MOUSE INT6_MOUSE DEIHRRA---NQINHINSN--- B4E2C8_HUMAN B4E2C8_HUMAN DETHRRA---NQINHINSN--- A8MV98_HUMAN A8MV98_HUMAN DEIHRRA---NQINHINSN--- INT6_HUMAN INT6_HUMAN DEIHRRA---NQINHINSN--- B3KQH5_HUMAN B3KQH5_HUMAN DEIHRRA---NQINHINSN--- Q95LX6_MACFA Q95LX6_MACFA DEIHRRA---NQINHINSN--- Q4R5Z8_MACFA Q4R5Z8_MACFA DEIHRRA---NQINHINSN--- INT6A_XENLA INT6A_XENLA EEIHRRA---SQVNHLSSC--- INT6B_XENLA INT6B_XENLA EEIHRRT---NQVNHLSSC--- MATCH : . CONSENSUS ??I???????N??NH??S????


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