Alignment of the gene Family HBG096290 of HOVERGEN

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Isoforms are ON
Q4SV81_TETNG Q4SV81_TETNG ETEGF----------------HTDARYPEAVSLWHVVPNSGGLDS--------------- SHRM2_XENTR SHRM2_XENTR LVLGCLQCFTSAWGFASRRICHSSSATPGQHSVGLGHGYQHGAQSWAERFLLRYKGLLWF B6Z9Q5_BOVIN B6Z9Q5_BOVIN -MEGA----------------EPRAR-PERLAEA-------------------------- SHRM2_HUMAN SHRM2_HUMAN -MEGA----------------EPRAR-PERLAEA-------------------------- SHRM2_RAT SHRM2_RAT ------------------------------------------------------------ A7TU71_MOUSE A7TU71_MOUSE -MEGA----------------EPRAR-PERLAEA-------------------------- SHRM2_MOUSE SHRM2_MOUSE -MEGA----------------EPRAR-PERLAEA-------------------------- MATCH CONSENSUS ???G???????????????????????P????????????????????????????????

Q4SV81_TETNG Q4SV81_TETNG -RCREAEAWKLVSVCLSGGAPW-------GFTLRGGLEHREPLLITKVEEGSQAAAVN-L SHRM2_XENTR SHRM2_XENTR VGSRAHSGGEETNGKLQAGGCYSYWRGSLGIYFERGKEHGEPLIITKVEDGNKAADI--L B6Z9Q5_BOVIN B6Z9Q5_BOVIN -EARTADGGRLVEVQLSGGAPW-------GFTLKGGREHGEPLVITKVEEGSKAAAVDKL SHRM2_HUMAN SHRM2_HUMAN -ETRAADGGRLVEVQLSGGAPW-------GFTLKGGREHGEPLVITKIEEGSKAAAVDKL SHRM2_RAT SHRM2_RAT ------------------------------------------------------------ A7TU71_MOUSE A7TU71_MOUSE -EAPATDGVRLVEVQLSGGAPW-------GFTLKGGREHGEPLVITKIEEGSKAAAVDKL SHRM2_MOUSE SHRM2_MOUSE -EAPATDGVRLVEVQLSGGAPW-------GFTLKGGREHGEPLVITKIEEGSKAAAVDKL MATCH CONSENSUS ???????????????L??G??????????G?????G?EH?EPL?ITK?E?G??AA????L

Q4SV81_TETNG Q4SV81_TETNG QVGDELVNINEVPLSGYRQEAICLVKGSHKTLSLVVKRRNDPISRPHSWHSTKFNENQSD SHRM2_XENTR SHRM2_XENTR MAGDEIVNINDQQLLGYRQEAICLVKGSHKILKMIVKRRNDISYRPHSWHSNKLIESAMD B6Z9Q5_BOVIN B6Z9Q5_BOVIN LAGDEIVGINDVGLSGFRQEAICLVKGSHKTLKLVVKRRNELNWRPHSWHATKFSDSQSE SHRM2_HUMAN SHRM2_HUMAN LAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPE SHRM2_RAT SHRM2_RAT -------------------------------------------MRPSTVT---------- A7TU71_MOUSE A7TU71_MOUSE LAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPE SHRM2_MOUSE SHRM2_MOUSE LAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPE MATCH ** : CONSENSUS ??GDE?V?IN???L?G?RQEAICLVKGSHK?L???VKR??????RPHSWH??K???????

Q4SV81_TETNG Q4SV81_TETNG TAKAQSPP---MPVWHTTYDASSSSTDLS-SSWERTNLRRASDQFSSLGSMDSLEQGSHP SHRM2_XENTR SHRM2_XENTR TVTPQMSNA--SPFWNARYRSSSSSHDLS-NPWDQTSLQRNSGHFSSMGSMDSIDQT--- B6Z9Q5_BOVIN B6Z9Q5_BOVIN PAAPLLP----CPSRPSRYHASSSSQDLSGGAWEPANLQRTSDHFSSLGSVDSLDPSSQP SHRM2_HUMAN SHRM2_HUMAN LAASPFTSTSGCPSWSGRHHASSSSHDLS-SSWEQTNLQRTLDHFSSLGSVDSLDH---- SHRM2_RAT SHRM2_RAT -----------SRIWWSE-SSSSSSHDLS-GSWEHTSLQRTSDHFSSMGSIDSLDHSSQL A7TU71_MOUSE A7TU71_MOUSE PAASLFLNTSGSPSWKSQHQASSSSHDLS-GSWEHTSLQRTSDHFSSMGSIDSLDHSSQL SHRM2_MOUSE SHRM2_MOUSE PAASLFLNTSGSPSWKSQHQASSSSHDLS-GSWEHTSLQRTSDHFSSMGSIDSLDHSSQL MATCH :**** *** ..*: :.*:* .:***:**:**:: CONSENSUS ????????????P?W??????SSSS?DLS???WE?T?LQR?SDHFSS?GS?DSLD?????

Q4SV81_TETNG Q4SV81_TETNG YAAGQLSPTKSSSSIDRLGA-GKRDSAYSSFSTSSGTPDYTISKSNAASTENMLHRCSQW SHRM2_XENTR SHRM2_XENTR YQFGRLSSAKSNNSIDYVGSQNKRDSAYGSFSASFSTPDHTLSKTASASTENILYKNNEW B6Z9Q5_BOVIN B6Z9Q5_BOVIN DPSGRLSAAKSSSSIDRLGGASKRDSAYGSFSTRSSTPDHTLPKADASSAENILYKVGLW SHRM2_HUMAN SHRM2_HUMAN -PSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLW SHRM2_RAT SHRM2_RAT YPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLW A7TU71_MOUSE A7TU71_MOUSE YPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLW SHRM2_MOUSE SHRM2_MOUSE YPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLW MATCH .:** :**..*** :*. .******.***: .***:*:.*: ::*:**:*: . * CONSENSUS ???G?LS?AKS?SSID?LG???KRDSAYGSFST?SSTPDHTL?K????S?ENILY????W

Q4SV81_TETNG Q4SV81_TETNG DSGGKG-------VGGRNSQDERLAY--SNLPGVSCEAPPTEESSGSRHSISSKTSFGPV SHRM2_XENTR SHRM2_XENTR DNTKLGYGKTSPSMNEVRRSADRQVLQSTSIN-ETSKIQRTEDNTEPRYS--GRSNFGPV B6Z9Q5_BOVIN B6Z9Q5_BOVIN EASAAADRRPGLAAGDPQGTEEPLGCFPPRVP---------EDGPEPKLAACGRSSSGPV SHRM2_HUMAN SHRM2_HUMAN EAPRQG-GRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPV SHRM2_RAT SHRM2_RAT EASRPGSSRQSQSTGDPQGLQDRPSSFLPRVPGNSSKSPRPEDNIEPKIATSGRSNFGPV A7TU71_MOUSE A7TU71_MOUSE EASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPV SHRM2_MOUSE SHRM2_MOUSE EASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPV MATCH : . . . : . : * . .: : .::. *** CONSENSUS ?????G????????G????????????????P?????????E???EP?????GRS?FGPV

Q4SV81_TETNG Q4SV81_TETNG WHVPEKKKAAGPSPPPPPPPPLAPPPPPPPARSDSFA-ATRVHERGFMAQSEGPELK-PS SHRM2_XENTR SHRM2_XENTR WNIPDKKKT-----------A-SPPPPPPPQRSDSYA-VTKIHEK-----PTNLMHL-DA B6Z9Q5_BOVIN B6Z9Q5_BOVIN WYVPDKRRA-----------PPSPPPPPPPLRRDSFA-ATRIHEQ-----TQGPTVSADA SHRM2_HUMAN SHRM2_HUMAN WYVPDKKKA-----------PSSPPPPPPPLRSDSFA-ATKSHEK-----AQGPVFS-EA SHRM2_RAT SHRM2_RAT WYVPDKKKA-----------P-SPPPLGLPLRSDSFAVAARGHEK-----ARGPPFS-DL A7TU71_MOUSE A7TU71_MOUSE WYVPDKKKA-----------P-SPPPLGLPLRSDSFSVAARGHEK-----ARGPPFS-DL SHRM2_MOUSE SHRM2_MOUSE WYVPDKKKA-----------P-SPPPLGLPLRSDSFSVAARGHEK-----ARGPPFS-DL MATCH * :*:*::: . :*** * * **:: .:: **: . . CONSENSUS W?VPDKKKA???????????P?SPPP???P?RSDSF??A???HE????????GP??????

Q4SV81_TETNG Q4SV81_TETNG LESRRSSNLSPKMDRDAFHSSDRSILKQFSSHKQFSLSGSDVQQSQACQQRLHSDKGALP SHRM2_XENTR SHRM2_XENTR SSTQHFNVANRSQAKPDWSLEISEQQRPIRAHDRTVADTRRTSNS-SYHAGLNADQGLSP B6Z9Q5_BOVIN B6Z9Q5_BOVIN APAQPLPGLSCVQPHGGDWKRPEPADQLLRPARGAD--GRRAASS-GCAPGAHVDCGWPA SHRM2_HUMAN SHRM2_HUMAN AAAQHFTALAQAQPRGD--RRPELTDRPWRSAHPGSL-GKGSGGP-GCPQEAHADGSWPP SHRM2_RAT SHRM2_RAT ASMQHFTTLPHVQPRGD--RRMETTDRQWKLAHPSS--GKEIGNV-GYQPEGHLDCRWLC A7TU71_MOUSE A7TU71_MOUSE ASMQHFITLPHVQPRGD--HRMETTDRQWKLTHLSS--GKEIGNV-GYQSEGHLDCRWLC SHRM2_MOUSE SHRM2_MOUSE ASMQHFITLPHVQPRGD--HRMETTDRQWKLTHLSS--GKEIGNV-GYQSEGHLDCRWLC MATCH : : : . : * CONSENSUS ???Q????L???Q?????????????????????????G?????????????H?D?????

Q4SV81_TETNG Q4SV81_TETNG SQPWAPS------------------FPKPQSGGG--SYCSTPEPPVNGSAQHF------- SHRM2_XENTR SHRM2_XENTR YKDKYPSNLPNVSRIQASLSTNDVRFAQPAYNYHHQRQYSDESTLFQSTRTSAQHKSQQQ B6Z9Q5_BOVIN B6Z9Q5_BOVIN CDSGSRALLGAPSRLQASLSSTDVRRPQPSPVCQHPRHLSDEGPFFRKGPRATT------ SHRM2_HUMAN SHRM2_HUMAN SKDGASS------RLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCAD------------ SHRM2_RAT SHRM2_RAT SDDRAGRPSGAPGRHQFSLSSTDVHFLKSYHGSQHPQPCSDESPRFPSSPRELLRITP-- A7TU71_MOUSE A7TU71_MOUSE SDDRAGRPSGPPGRLQFS----DVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITP-- SHRM2_MOUSE SHRM2_MOUSE SDDRAGRPSGPPGRLQFS----DVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITP-- MATCH . :. * . CONSENSUS ?????????????R?Q?S????DV?F????????H????SD??P????????????????

Q4SV81_TETNG Q4SV81_TETNG -----GQTQRKSSTASSSN----------------TVADPSADISGQNQYYCVTTNLPCK SHRM2_XENTR SHRM2_XENTR PMKYESSVNQVPSDLTYVYHPHQ--FRAPATSAGFSSGKQNVENNGQNHFHVVSIKHPQG B6Z9Q5_BOVIN B6Z9Q5_BOVIN -----WLGEPLPADCLGDNTPAAIVIGGP------RAADQRGDCSAQSRYYCVMSRP--- SHRM2_HUMAN SHRM2_HUMAN -----SLGQEPGAASFQNDSPPQ--VRGL------SSCDQKLGSGWQGP------RPCVQ SHRM2_RAT SHRM2_RAT -----SGCLQEPPELSQDDNPAQ--VRWP------GSVNQKLDDRGRSHYFSVPHRQPVH A7TU71_MOUSE A7TU71_MOUSE -----GGGLQEPPEPSQDDNPTQ--VRWP------GSAHQKLDDRGRSHYFPGSLRQPVQ SHRM2_MOUSE SHRM2_MOUSE -----GGGLQEPPEPSQDDNPTQ--VRWP------GSAHQKLDDRGRSHYFPGSLRQPVQ MATCH . . :. . CONSENSUS ????????????????????P??????????????????Q????????????????????

Q4SV81_TETNG Q4SV81_TETNG PEEQAKGGNQQKPVSPPALTKARYSLPQPQQQVKETSGYSRHPVAMAAESCMPKSN---T SHRM2_XENTR SHRM2_XENTR NTTHHQFKEEENYAPEVNSGRKSVQPENTVISIEIPAYSLPQESFEPSQINCEKNYLKIS B6Z9Q5_BOVIN B6Z9Q5_BOVIN ---------GPQWGAPAP----------------QPRCYPSRLEGAPG-----------A SHRM2_HUMAN SHRM2_HUMAN GDLQAAQLWAGCWPSDTALGALESLPPPTVGQ--SPRHHLPQPEGPPD-----------A SHRM2_RAT SHRM2_RAT GSAHVLIPRSDYWHSDTTPVDLECPLLRP-----DQRGYPQQYEETPA-----------S A7TU71_MOUSE A7TU71_MOUSE GSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQ----RTYLQQHEETPA-----------S SHRM2_MOUSE SHRM2_MOUSE GSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQ----RTYLQQHEETPA-----------S MATCH . : . : CONSENSUS ??????????????????????????????????????????????P?????????????

Q4SV81_TETNG Q4SV81_TETNG DERGGHRGL-----GTPTPASNSPSGRQLEQRRPSQPPHRESFQEIRNQSQASNKMCPQS SHRM2_XENTR SHRM2_XENTR EKKDNYLGNNEQIINKTTGYSEEKCNDRFSQLDHSEKGSYRSSQDYSWRKEEN-KITPLV B6Z9Q5_BOVIN B6Z9Q5_BOVIN RQRSRADPVDR-------APEDPPGAGLLDR-----GGRKRVVGSL---DDGGGEICPLQ SHRM2_HUMAN SHRM2_HUMAN RETGRCYPLDKGAEGCSAGAQEPPRASRAEK------ASQRLAASITWADGESSRICPQE SHRM2_RAT SHRM2_RAT HERGGYQQLNAGIEGCCSGIHEPPRASHTVR-----AGLQCPGNDFKLVDAESGRISRQR A7TU71_MOUSE A7TU71_MOUSE HEKEGYHQLNAGIEGCCSGIQEPPRASRTVR-----TGLQCPSNDFKLVDGESGRISRQR SHRM2_MOUSE SHRM2_MOUSE HEKEGYHQLNAGIEGCCSGIQEPPRASRTVR-----TGLQCPSNDFKLVDGESGRISRQR MATCH : : : . . . .: CONSENSUS ???????????????????????P???????????????????????????????I????

Q4SV81_TETNG Q4SV81_TETNG APLLHSLTVD--------DGAGLERTGASESLESKQLRRSERFATTLRNEIQMRKAQLQK SHRM2_XENTR SHRM2_XENTR TPMLHSLAQEGRNRSESFPDTGNEKLSFPDA--GKQSRRSDRFATTLRNEIQQRRARLQK B6Z9Q5_BOVIN B6Z9Q5_BOVIN TPMLHSLSRERACPPETRHKDMAPAPP--EALAGKPLRRSDRFATTLRNEIQQRRARLQK SHRM2_HUMAN SHRM2_HUMAN TPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQK SHRM2_RAT SHRM2_RAT TPMLHSLTQDGAWRPGNSKDCGNEKPPLLDAQVGKPTRRSDRFATTLRNEIQMRRAKLQK A7TU71_MOUSE A7TU71_MOUSE TPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQK SHRM2_MOUSE SHRM2_MOUSE TPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQK MATCH :*:****: : :: .* ***:*********** ::*:*** CONSENSUS TP?LHSL???????????????????????A??GK??RRSDRFATTLRNEIQ?RRA?LQK

Q4SV81_TETNG Q4SV81_TETNG SKSVSTLPNLEAETD---------DDQELWESKHPPHVSA--AGSFT-NTYKVNLKEAQA SHRM2_XENTR SHRM2_XENTR SKSTAALTE-SNETE----------TSDNWKQDSLESMSPTSEGSFS-STYRSHLQEAQA B6Z9Q5_BOVIN B6Z9Q5_BOVIN SRSTATLAS-SAEEEGEVEDDVETEARGSWAQPVG---AP--ETTFPSGTYKDHLKEAQA SHRM2_HUMAN SHRM2_HUMAN SRSTVALTA-AGEAE---------DGTGRWRAGLGGG-TQ--EGPLA-GTYKDHLKEAQA SHRM2_RAT SHRM2_RAT SKSTVTLAG-DSEAE---------DCAGDWRVDVGA--VP--EGSFP-STYKEHLKEAQT A7TU71_MOUSE A7TU71_MOUSE SKSTVTLAG-DSEAE---------DCAGDWRADVGA--VP--EGSFP-STYKEHLKEAQT SHRM2_MOUSE SHRM2_MOUSE SKSTVTLAG-DSEAE---------DCAGDWRADVGA--VP--EGSFP-STYKEHLKEAQT MATCH *:*. :*. * : * .:. .**: :*:***: CONSENSUS S?ST??L?????E?E??????????????W????????????EG?F???TYK?HLKEAQ?

Q4SV81_TETNG Q4SV81_TETNG RVLMATSFQRKDLEPVLLD-NPAAEAPPNYPPPGLPC-----KDAHSLPPVLESEISKPG SHRM2_XENTR SHRM2_XENTR RVLRATSFKRRDLDTGISD-HLSLFQDRNMQISSFSGLSLDPVQPKKNTAVNSSQ----- B6Z9Q5_BOVIN B6Z9Q5_BOVIN RVLRATSFRRRDLDLSLADPEPAP---RVWE-----------GAPGARPPLCAAG----- SHRM2_HUMAN SHRM2_HUMAN RVLRATSFKRRDLDPNPGDLYPESLEHRM-------------GDPDTVPHFWEAGLAQPP SHRM2_RAT SHRM2_RAT RVLKATSFQRRDLDPTPADQYPGPPEHRTCDHSASSSLSSFPGEPDSAPRLCEAGLAKPP A7TU71_MOUSE A7TU71_MOUSE RVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAP SHRM2_MOUSE SHRM2_MOUSE RVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAP MATCH *** ****:*:**: * . . . : CONSENSUS RVL?ATSF?RRDLD????D????????R????????????????P???P???????????

Q4SV81_TETNG Q4SV81_TETNG AASG---QVSRIGCRKRFPAEKKVRSFSEPDKIHEVGVNEELSCLESPSSS-------FD SHRM2_XENTR SHRM2_XENTR -------NVSRIGARKRFTTQQKLMSYSEPEKINEVGVEDQYN-FRTENSTKRTVGSFAD B6Z9Q5_BOVIN B6Z9Q5_BOVIN --SGSGSGSARIGSRRRFTAEQKLKSYSEPEKMNAVGLTGDQSPAPH----DETLWTFAD SHRM2_HUMAN SHRM2_HUMAN SSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFAD SHRM2_RAT SHRM2_RAT SSAGGVPHILRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHSPHPTIRTSEDSVGTFAD A7TU71_MOUSE A7TU71_MOUSE SSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFAD SHRM2_MOUSE SHRM2_MOUSE SSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFAD MATCH *** *:**.:::*: *:***:*:: **: * CONSENSUS ??????????RIG?R?RFTAEQKL?SYSEPEK?NEVG????????????????????FAD

Q4SV81_TETNG Q4SV81_TETNG QDSLFKESGKSAVFSYAPPQSVMENPPKPKEEAPSSRSDTGGANT--------------G SHRM2_XENTR SHRM2_XENTR RWKFFEETSKC-AQPKVPPKVVSSSQSEETSEIAINRDYAKSSEGQES---KRALAVSGQ B6Z9Q5_BOVIN B6Z9Q5_BOVIN RWKFFEETSKP-VGPQPGPRPAPCGFPREKPEML--WTVGPGKDG--------------- SHRM2_HUMAN SHRM2_HUMAN RWKFFEETSKP-VPQRPAQKQALHGIPRDKPERP--RTAGRTCEGTEPW----SRTTSLG SHRM2_RAT SHRM2_RAT RWKFFEETSKS-LLQKPGHRQAFCGIPREKAERP--QTQGHECESTEPWFQKRSRATSCG A7TU71_MOUSE A7TU71_MOUSE RWKFFEETSKS-LLQKAGHRQVHCGLPREKAERP--QTGHHECESTEPWFQKRSLATSCG SHRM2_MOUSE SHRM2_MOUSE RWKFFEETSKS-LLQKAGHRQVHCGLPREKAERP--QTGHHECESTEPWFQKRSLATSCG MATCH : .:*:*:.* : . . .. . * : CONSENSUS RWKFFEETSK????????????????P??K?E????????????????????????????

Q4SV81_TETNG Q4SV81_TETNG SRSREHTQEQPTNRPAVPDQQRLGTFAEYEAKWSTQGRKPEPKGSGRYRSVDNILHPGPV SHRM2_XENTR SHRM2_XENTR NPADENGFPDKVTT--ER-RQRLGTFAEYEASWKEQKTQLERKNSGRCHSADNILDADLE B6Z9Q5_BOVIN B6Z9Q5_BOVIN ----------KAGRP-IP-PERLGTFAEYQASWREQRKVPEARGGGRYHSTDNILDVGVD SHRM2_HUMAN SHRM2_HUMAN DSLNAHSAAEKAGTS-DL-PRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLD SHRM2_RAT SHRM2_RAT EILSEDRKVEKASEKLNP-PRRLGTFAEYQASWKEQKKSLEARSSGRYHSADDILDAGLD A7TU71_MOUSE A7TU71_MOUSE EILSD-RKVEKASEKLNP-PRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLD SHRM2_MOUSE SHRM2_MOUSE EILSD-RKVEKASEKLNP-PRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLD MATCH . .********:*.* * * :..** :*.*:**. . CONSENSUS ??????????K??????????RLGTFAEY?ASW?EQ????E???SGR?HS?D?ILD????

Q4SV81_TETNG Q4SV81_TETNG ERTKSNGFHERSRSSPSADVYGQKIPVPARQPDLEFSPPGTKPAEPLNAATRSADGGSSE SHRM2_XENTR SHRM2_XENTR QNPKAQYIHERSKSSPTTDFYAQAAAV---ESKQQSESVR-RDTENSNSTHCRSSTGDSP B6Z9Q5_BOVIN B6Z9Q5_BOVIN QEERPQYVHERSRSSPSTDLYKQDASM---EPRWEAGDPE-EHTE--------------- SHRM2_HUMAN SHRM2_HUMAN PQERPQHVHGRSRSSPSTDHYKQEASV---ELRRQAGDPG-EPREELPSA-VRAEEGQST SHRM2_RAT SHRM2_RAT QQQRPQYIHERSRSSPSTDHYSQEVPV---EPNRQAEDSG-GQKEALLCT-LQAEEGCSA A7TU71_MOUSE A7TU71_MOUSE QQQRPQYIHERSRSSPSTDHYSQEVPV---EPNRQAEDSG-DHKEAILCT-LQAEEGCSA SHRM2_MOUSE SHRM2_MOUSE QQQRPQYIHERSRSSPSTDHYSQEVPV---EPNRQAEDSG-DHKEAILCT-LQAEEGCSA MATCH . :.: .* **:***::* * * .: : : * CONSENSUS ?????Q??HERSRSSPSTD?Y?Q???V???E?????????????E???????????G?S?

Q4SV81_TETNG Q4SV81_TETNG GRETSVGCD--------------------------------------------------- SHRM2_XENTR SHRM2_XENTR TRTVEAGDQCGATNEQEVLTCNTKWKP--HDKSFPIPETSNESQQSRARSGTLPNDYRFA B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN PRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYS SHRM2_RAT SHRM2_RAT P----------------------------------------------------------- A7TU71_MOUSE A7TU71_MOUSE P----------------------------------------------------------- SHRM2_MOUSE SHRM2_MOUSE P----------------------------------------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SV81_TETNG Q4SV81_TETNG ----------------PLSRAPPPPVTGANPDSRPRAAPATESRRATSVPHSPAESKDPG SHRM2_XENTR SHRM2_XENTR HENVNQGNRDISFSAVPISEACPDFSNADSDQLQDHPSVFKKRSAAPQRPPPPKLENKYW B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN EESTPA-------DLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRY SHRM2_RAT SHRM2_RAT ------------------------------------------------------------ A7TU71_MOUSE A7TU71_MOUSE ------------------------------------------------------------ SHRM2_MOUSE SHRM2_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SV81_TETNG Q4SV81_TETNG PAEPLSGPWTRPPPPRCPEISPHEPFTHSQSKVFSHHPPSSNTNPASLTSHTAEGESERS SHRM2_XENTR SHRM2_XENTR RQNGSSSSLATSSESLLTAQARRAQ-SYSPSSQDTFPPQSLQKQSPSTYPDKNPSIHIYD B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------LSSAAPAE---- SHRM2_HUMAN SHRM2_HUMAN RATDGA-----PADAPVGVLGRPFP-TPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKA SHRM2_RAT SHRM2_RAT --------------------------------------------SSSVLSSAQPQD---- A7TU71_MOUSE A7TU71_MOUSE --------------------------------------------SSSVLSSAQPQD---- SHRM2_MOUSE SHRM2_MOUSE --------------------------------------------------SAQPQD---- MATCH CONSENSUS ?????????????????????????????????????????????????????P??????

Q4SV81_TETNG Q4SV81_TETNG TRLADPGPEAEPHFPTSDPERESSPPAP---SGPAGMEGQRSPSPEFFPQRLSDKPPLSA SHRM2_XENTR SHRM2_XENTR YQLSVPPENDRYHLEKKYFESELSSKSH---LQIPGMEPSRSPSPQFAPQKLTDKPPLLV B6Z9Q5_BOVIN B6Z9Q5_BOVIN ---------------------------------------DRSPTPR-------------- SHRM2_HUMAN SHRM2_HUMAN TVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLI SHRM2_RAT SHRM2_RAT ------SQHVNEDPTSPQPEAQLSSKCQH--LQTSTMETSRSPSPQFAPQKLTDKPPLLI A7TU71_MOUSE A7TU71_MOUSE ------SQHVNEDTTFPQPETQLSSKCQH--LQTSAMETSRSPSPQFAPQKLTDKPPLLI SHRM2_MOUSE SHRM2_MOUSE ------SQHVNEDTTFPQPETQLSSKCQH--LQTSAMETSRSPSPQFAPQKLTDKPPLLI MATCH .***:*. CONSENSUS ???????????????????E????????????????ME??RSPSP?F?PQ?L?DKPPL??

Q4SV81_TETNG Q4SV81_TETNG QEQLSNR------------------------------VTHVTENQSSAARRVPIRIVHSE SHRM2_XENTR SHRM2_XENTR PEENLSR------------------------------IERVIDNTT--VKMVPIKIVHSE B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN QDEDSTR------------------------------IERVMDNNTT-VKMVPIKIVHSE SHRM2_RAT SHRM2_RAT HEDNSARYCPVTACYVFIPCRLQVFVAGALPQLQTLGIERVMDNNTT-VKMVPIKIVHSE A7TU71_MOUSE A7TU71_MOUSE HEDNSAR------------------------------IERVMDNNTT-VKMVPIKIVHSE SHRM2_MOUSE SHRM2_MOUSE HEDNSAR------------------------------IERVMDNNTT-VKMVPIKIVHSE MATCH CONSENSUS ??????R?????????????????????????????????V??N???????VPI?IVHSE

Q4SV81_TETNG Q4SV81_TETNG AATEKES-----CPFLQPAEPEAPGVTRLNSLGAAGQD-SGFCAFTRQREAGGAPGSRAD SHRM2_XENTR SHRM2_XENTR THAEKESRHNLLSAIEPTALPTGLAKDQLKTLSTSEQSYSRFCAYTRQESREEEESRVTD B6Z9Q5_BOVIN B6Z9Q5_BOVIN ----------------------------------------------RQRTQS-------- SHRM2_HUMAN SHRM2_HUMAN SQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQP SHRM2_RAT SHRM2_RAT SQPEKESRQSLACPAELPALPSGLEKDQIKTLSTSEQCYSRFCVYTRQEVET--PHRARP A7TU71_MOUSE A7TU71_MOUSE SQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEA--PHRARP SHRM2_MOUSE SHRM2_MOUSE SQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEA--PHRARP MATCH ** CONSENSUS ???EKES?????????????P??????????L????Q??S?FC??TRQ????????????

Q4SV81_TETNG Q4SV81_TETNG TRPQRPTYMSPVGDPTSSGPRSPPQGPEESSSTGPAAPTGLSEDQKREELAKDIMGKDKS SHRM2_XENTR SHRM2_XENTR LYSCQRNAEDDNENDVSSLAPS--NAKSKDAIY---------ADLKSEELVREIVDKDKS B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN AEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTV---------EDLKSEELAREIVGKDKS SHRM2_RAT SHRM2_RAT PEPQPPSTPAPPVRDSCSSPPSLNYGKAKEKTV---------DDLKSEELAREIVGKDKS A7TU71_MOUSE A7TU71_MOUSE PEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTM---------DDLKSEELAREIVGKDKS SHRM2_MOUSE SHRM2_MOUSE PEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTM---------DDLKSEELAREIVGKDKS MATCH CONSENSUS ???????????????????????????????????????????D?K?EEL???I??KDKS

Q4SV81_TETNG Q4SV81_TETNG LVEVLDRS-RMKTTMDLMEGIFPQDQQLLEGAHQRRKVLPKATGPRPSEE---------- SHRM2_XENTR SHRM2_XENTR LADILDPNAKMRTTMDLMEGIFPKDEHLLEEAQQRRKHLPKIPSPRSTDD---------- B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN LADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEE---------- SHRM2_RAT SHRM2_RAT LADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPSPRVTEDNSCPSLSAIC A7TU71_MOUSE A7TU71_MOUSE LADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTED---------- SHRM2_MOUSE SHRM2_MOUSE LADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTED---------- MATCH CONSENSUS L???LD??????TTMDLMEGIFP?D??LLE?A?QRRK?LPK???PR??????????????

Q4SV81_TETNG Q4SV81_TETNG --------------------------RDKDCTPAAVTMVTNSTYYSTSAPKAELLIKMKD SHRM2_XENTR SHRM2_XENTR -------------------------KKDEQNVPSAVSLTTSSTYYSTSAAKAELLIKMKD B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN -------------------------RKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKD SHRM2_RAT SHRM2_RAT YNLGTRSKSVPVSQLIKIKILASSPRKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKD A7TU71_MOUSE A7TU71_MOUSE -------------------------KKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKD SHRM2_MOUSE SHRM2_MOUSE -------------------------KKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKD MATCH CONSENSUS ????????????????????????????????P??V???T?STYYSTSA?KAELLIKMKD

Q4SV81_TETNG Q4SV81_TETNG MQEEEEEEEENSEDELDMDLATKKQELISSLSQKLQVLREVRESLLEDILDNNALGDEVE SHRM2_XENTR SHRM2_XENTR MQ-EQQHIAENSEDELGQNLSEKKQELIDSISKKLQVLRDAKETLLEDVQCNNALGEEVE B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN LQ-EQQEHEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVE SHRM2_RAT SHRM2_RAT LQ----EPEEYSAGDLDHDLSIKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVE A7TU71_MOUSE A7TU71_MOUSE LQ----EPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVE SHRM2_MOUSE SHRM2_MOUSE LQ----EPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVE MATCH CONSENSUS ?Q???????E?S???L???L??KKQELI?S?S?KLQVLR???E?LLED???N??LG?EVE

Q4SV81_TETNG Q4SV81_TETNG SKVQRVCKPNELDKFRMFVGDLDKVVSLLLSLSGRLARVENALNSLDHDATEDERRTLTE SHRM2_XENTR SHRM2_XENTR IIVKEVCKPNEFDKFRMFIGDLEKIVNLLLSLSGRLARVENALNNLDETVSPEERKTLLE B6Z9Q5_BOVIN B6Z9Q5_BOVIN ---------------------------------GRQAR---------------------- SHRM2_HUMAN SHRM2_HUMAN AIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLE SHRM2_RAT SHRM2_RAT AIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSPSPGDRQSLLE A7TU71_MOUSE A7TU71_MOUSE AIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLE SHRM2_MOUSE SHRM2_MOUSE AIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLE MATCH ** ** CONSENSUS ??V??VCKP?E?DKFRMF?GDL?K?V?LLLSLSGRLARVENALN?LD???????R??L?E

Q4SV81_TETNG Q4SV81_TETNG KRKLLIRQHEDAKELKENLDRRERVVYEILGNYLPEDCLTDYEHFVKMKSALIIEQRKLE SHRM2_XENTR SHRM2_XENTR KRKLLTRQHEDAKELKENLDRRERTVYEILANYLNEENLADYEHFVKMKSALILEQRELE B6Z9Q5_BOVIN B6Z9Q5_BOVIN ------------------------------------------------------------ SHRM2_HUMAN SHRM2_HUMAN KQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELE SHRM2_RAT SHRM2_RAT KQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELE A7TU71_MOUSE A7TU71_MOUSE KQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELE SHRM2_MOUSE SHRM2_MOUSE KQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELE MATCH CONSENSUS K???L??QHEDAKELKENLDRRER?V??IL??YL?E??L?DYEHFVKMKSALI?EQR?LE

Q4SV81_TETNG Q4SV81_TETNG DKIKLGEEQLKCLLDSLPAEQR- SHRM2_XENTR SHRM2_XENTR DKIKLRESQLKCLTDSLPLDRIK B6Z9Q5_BOVIN B6Z9Q5_BOVIN ---------------SRRAERG- SHRM2_HUMAN SHRM2_HUMAN DKIHLGEEQLKCLLDSLQPERGK SHRM2_RAT SHRM2_RAT DKIHLGEEQLKCLFDSLQPERSK A7TU71_MOUSE A7TU71_MOUSE DKIHLGEEQLKCLFDSLQPERSK SHRM2_MOUSE SHRM2_MOUSE DKIHLGEEQLKCLFDSLQPERSK MATCH * :: CONSENSUS DKI?L?E?QLKCL?DSL??ER??


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