Alignment of the gene Family HBG098487 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
GUC2D_RAT GUC2D_RAT AGLQQGCHPEGQDWTAPHWKTCRALPGPRGL-------TVRHLRTVSSIS---------- Q4TAT8_TETNG Q4TAT8_TETNG ------------------------------------------------------------ P79999_ORYLA P79999_ORYLA ------------------------------------------------------------ Q7T2Q2_ORYLA Q7T2Q2_ORYLA ------------------------------------------------------------ A2BFQ0_DANRE A2BFQ0_DANRE --MNDHTSFLCQSHHPRWQTQSSAGKRRRKQSSSQKSETPASPVSSSPVL---------- Q4S8Y6_TETNG Q4S8Y6_TETNG ------------------------------------------------------------ P87343_ORYLA P87343_ORYLA TNHRDTCRLHNLAYHPPWWHSTTKMKRNKDTRTTSSSEGCRQLKTLSALLLTSSLSKPQL Q9W616_ORYLA Q9W616_ORYLA TNHRDSCRLHNLAYHPPWWHSTTKMKRNKDTRTTSSSEGCRQLKTLSALLLTSSLSKPQL Q4T7P7_TETNG Q4T7P7_TETNG ------------------------------------------------------------ Q7T3I2_ORYLA Q7T3I2_ORYLA ----MVVVWSEMPHQGAALSSKPPSHTPP---------ALTSVLSLSPGP---------- Q9W615_ORYLA Q9W615_ORYLA ----MVVVWSEMPHQGAALSSKPPSHTPP---------ALTSVLSLSPGP---------- O57480_CHICK O57480_CHICK ------------------------------------------------------------ GUC2E_RAT GUC2E_RAT -----MSAWLLPAGGFPGAGFCIPAWQ-----------SRSSLSRVLRWP---------- Q8C8X5_MOUSE Q8C8X5_MOUSE -----MSAWLLPAGGLPGAGFCVPARQ-----------SPSSFSRVLRWP---------- B1ASX7_MOUSE B1ASX7_MOUSE -----MSAWLLPAGGLPGAGFCVPARQ-----------SPSSFSRVLRWP---------- GUC2E_MOUSE GUC2E_MOUSE -----MSAWLLPAGGLPGARFCVPARQ-----------SPSSFSRVLRWP---------- GUC2D_HUMAN GUC2D_HUMAN -----MTACARRAGGLPDPGLCGPAWWAPS--------LPRLPRALPRLP---------- GUC2D_BOVIN GUC2D_BOVIN -----MTACTFLAGGLRDPGLCGPTRWAP---------SPPGLPPIPPRP---------- GUC2D_CANFA GUC2D_CANFA -----MSACALLAGGLPDPRLCAPARWAR---------SPPGVPGAPPWP---------- GUC2F_BOVIN GUC2F_BOVIN ------------MFLAPWPFSHLMLWFV----------TLGRQRGQHGLA---------- GUC2F_HUMAN GUC2F_HUMAN ------------MFLGLGRFSRLVLWFA----------AFRKLLGHHGLA---------- GUC2F_MOUSE GUC2F_MOUSE ------------MFLGPWPFSRLLSWFA----------ISSRLSGQHGLP---------- GUC2F_RAT GUC2F_RAT ------------MFLGPWPFSRLLSWFA----------ISSRLSGQHGLT---------- Q9PUK0_RANPI Q9PUK0_RANPI ---------------MRTPDYCNVKKKKK---------KLARAEFGTRKS---------- B3DHF2_DANRE B3DHF2_DANRE -----MRHIHLPFGGALWQFSSYPCCP-----------VLRSRRSLSTLP---------- Q4SY29_TETNG Q4SY29_TETNG ----------------------------------------------MALP---------- P87342_ORYLA P87342_ORYLA ----------MQHISPNGWESNHPCVS-----------IERNRRTLQSLP---------- Q9W614_ORYLA Q9W614_ORYLA ----------MQHISPNGWESNHPCVS-----------IERNRRTLQSLP---------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

GUC2D_RAT GUC2D_RAT ------VFSVVFWGVLLWA--DSLSLPAWA----RETFTLGVLGPWDCDPIFAQALPSMA Q4TAT8_TETNG Q4TAT8_TETNG -----------------------------AW---SATFKIALVGPWSCDPMFSRAMATAA P79999_ORYLA P79999_ORYLA -----------MMHFCFLLVCPCLLSITSVH---AATFKLALVGPWSCDPMFSRAMPSAA Q7T2Q2_ORYLA Q7T2Q2_ORYLA -----------MMHFCFLLVCPCLLSITSVH---AATFKLALVGPWSCDPMFSRAMPSAA A2BFQ0_DANRE A2BFQ0_DANRE ------RSHSWWGNCFLLPLVMLSYFPCEAW---GTTFKIAIVGPWACDPMYSKALPDLA Q4S8Y6_TETNG Q4S8Y6_TETNG -------------------------LPCQAW---ATTFKVALIGPWTCDLLYSKALPDLA P87343_ORYLA P87343_ORYLA PFSSMHLFRSWKEKLSLLFLFIISFFPCQIW---ATTFKVALVGPWTCDLLYSKALPDLA Q9W616_ORYLA Q9W616_ORYLA PFSSMHLFRSWKEKLSLLFLFIISFFPCQIW---ATTFKVALVGPWTCDLLYSKALPDLA Q4T7P7_TETNG Q4T7P7_TETNG -------------------LLSLCILPSLVE---AAWFRVGVVGPWECDPLFAKALPHVA Q7T3I2_ORYLA Q7T3I2_ORYLA ------APKHTLLRLLLLLLPPLCLLPCSAE---AAWFRVGVVGPWGCDPIFAKALPSTA Q9W615_ORYLA Q9W615_ORYLA ------APKHTLLRLLLLLLPPLCLLPCSAE---AAWFRVGVVGPWGCDPIFAKALPSTA O57480_CHICK O57480_CHICK ---------------------------------------VGVLGPWLCDPVASRALPELA GUC2E_RAT GUC2E_RAT -----------GPGLPGLLLLLLLPSPSAF----SAVFKVGVLGPWACDPIFARARPDLA Q8C8X5_MOUSE Q8C8X5_MOUSE -----------RPGLPGLLLLLLLPSPSAL----SAVFKVGVLGPWACDPIFARARPDLA B1ASX7_MOUSE B1ASX7_MOUSE -----------RPGLPGLLLLLLLPSPSAL----SAVFKVGVLGPWACDPIFARARPDLA GUC2E_MOUSE GUC2E_MOUSE -----------RPGLPGLLLLLLLPSPSAL----SAVFKVGVLGPWACDPIFARARPDLA GUC2D_HUMAN GUC2D_HUMAN -----------------LLLLLLLLQPPAL----SAVFTVGVLGPWACDPIFSRARPDLA GUC2D_BOVIN GUC2D_BOVIN -----------RLRLR-PPLLLLLLLPRSVL---SAVFTVGVLGPWACDPIFARARPDLA GUC2D_CANFA GUC2D_CANFA -----------QPRLRLLLLLLLLP-PSAL----SAVFTVGVLGPWACDPIFARARPDLA GUC2F_BOVIN GUC2F_BOVIN ----------SFKLLWCLWLLVLMSLPLQVW---APPYKIGVVGPWTCDPLFSKALPEIA GUC2F_HUMAN GUC2F_HUMAN ----------SAKFLWCLCLLSVMSLPQQVW---TLPYKIGVVGPWACDSLFSKALPEVA GUC2F_MOUSE GUC2F_MOUSE ----------SSKFLRCLCLLALLPLLRWGQ---ALPYKIGVIGPWTCDPFFSKALPEVA GUC2F_RAT GUC2F_RAT ----------SSKFLRYLCLLALLPL---IWWGQALPYKIGVIGPWTCDPFFSKALPEVA Q9PUK0_RANPI Q9PUK0_RANPI ----------------------------------PMTHRYSWLTRWITK----------- B3DHF2_DANRE B3DHF2_DANRE -----------FYSITLWIILGVLTFPRCVQ---CLVFKVGIIGPWNCDPNYAKSLPAIA Q4SY29_TETNG Q4SY29_TETNG -----------FYNLLLWVLLGAFTFPCCVR---CLIFKVGVLGPWNCDPVYHRAFPAAA P87342_ORYLA P87342_ORYLA -----------FYNIMLWLLLGVLTFPCCVH---CLIFKVGVLGPWNCDPVYYRALPTVA Q9W614_ORYLA Q9W614_ORYLA -----------FYNIMLWLLLGVLTFPCCVH---CLIFKVGVLGPWNCDPVYYRALPTVA MATCH . : * . CONSENSUS ???????????????????????????????????????????GPW?CDP????A?P??A

GUC2D_RAT GUC2D_RAT TQLAVDRVNQDASLLLGSQLDFKILPTGCDTPH------------------------ALA Q4TAT8_TETNG Q4TAT8_TETNG ANLALLRIQSDSSLSRGYHYSVKLLEEDCSLSKGPEPLASADRPAAAPTSLLLCFLPALT P79999_ORYLA P79999_ORYLA ANLALSRLRSDADLSRGFWYDVKLLNEDCSASK------------------------ALT Q7T2Q2_ORYLA Q7T2Q2_ORYLA ANLALSRLRSDADLSRGFWYDVKLLNEDCSASK------------------------ALT A2BFQ0_DANRE A2BFQ0_DANRE ARLAMSRINKDPELNKGYWYDYTVINEDCSSSR------------------------GLA Q4S8Y6_TETNG Q4S8Y6_TETNG ARLATSRINKDPDLNKGYWYDYTLINEDCKSSR------------------------ALA P87343_ORYLA P87343_ORYLA ARLAISRINKNPYLNRGYWYDYALVNEDCKSTR------------------------ALV Q9W616_ORYLA Q9W616_ORYLA ARLAISRINKNPYLNRGYWYDYALVNEDCKSTR------------------------ALV Q4T7P7_TETNG Q4T7P7_TETNG AQLAVNRINRDPSLSYAATFDYIVLQEPCETSR------------------------ALE Q7T3I2_ORYLA Q7T3I2_ORYLA AQLAITHINRDPSLSSAGAFDFAVLQEPCETSR------------------------ALE Q9W615_ORYLA Q9W615_ORYLA AQLAITHINRDPSLSSAGAFDFAVLQEPCETSR------------------------ALE O57480_CHICK O57480_CHICK SRLAVARLNRDPELSRGYWWDAVLLPEPCQTPQ------------------------AVT GUC2E_RAT GUC2E_RAT ARLATDRLNRDLALDGGPWFEVTLLPEPCLTPG------------------------SLG Q8C8X5_MOUSE Q8C8X5_MOUSE ARLAANRLNRDFALDGGPRFEVALLPEPCLTPG------------------------SLG B1ASX7_MOUSE B1ASX7_MOUSE ARLAANRLNRDFALDGGPRFEVALLPEPCLTPG------------------------SLG GUC2E_MOUSE GUC2E_MOUSE ARLAANRLNRDFGLDGGPRFEVALLPEPCLTPG------------------------SLG GUC2D_HUMAN GUC2D_HUMAN ARLAAARLNRDPGLAGGPRFEVALLPEPCRTPG------------------------SLG GUC2D_BOVIN GUC2D_BOVIN ARLAASRLNHAAALEGGPRFEVALLPEPCRTPG------------------------SLG GUC2D_CANFA GUC2D_CANFA ARLAAARLNRDAALEDGPRFEVTLLPEPCRTPG------------------------SLG GUC2F_BOVIN GUC2F_BOVIN AQLATERINKDPALDLGHSLEYVIFNEDCQASR------------------------ALS GUC2F_HUMAN GUC2F_HUMAN ARLAIERINRDPSFDLSYSFEYVILNEDCQTSR------------------------ALS GUC2F_MOUSE GUC2F_MOUSE AALAIERISRDKTFDRSYSFEYVILNEDCQTSK------------------------ALA GUC2F_RAT GUC2F_RAT AALAIERISRDMSFDRSYSFEYVILNEDCQTSK------------------------ALT Q9PUK0_RANPI Q9PUK0_RANPI -----------------FWRKT------VKPPK------------------------ALM B3DHF2_DANRE B3DHF2_DANRE SRLAVGRINNDFSLDLGCTMDFVILQEACETSK------------------------ALT Q4SY29_TETNG Q4SY29_TETNG AKLAGSRMNRDPSLDLGLEMEFVTLQEPCETSK------------------------ALN P87342_ORYLA P87342_ORYLA ARLAISRINRDPNLDLGLTMDFIILQEPCETSK------------------------AHT Q9W614_ORYLA Q9W614_ORYLA ARLAISRINRDPNLDLGLTMDFIILQEPCETSK------------------------ALT MATCH . . . CONSENSUS A?LA??R???D??L????????????E?C?????????????????????????????L?

GUC2D_RAT GUC2D_RAT TFVAHRNTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWAC-----GAPEGGGALVPTLPS Q4TAT8_TETNG Q4TAT8_TETNG GLGDMEGYGHVYIGPFNPMLCGAAALFAQHWEAGLASPGCLDANWPN-------LPPITP P79999_ORYLA P79999_ORYLA ELGEMEGYGHAYIGPFNPALCHAASLMAQHWDAGLASPGCLDPVWLN-------LPPITP Q7T2Q2_ORYLA Q7T2Q2_ORYLA ELGEMEGYGHAYIGPFNPALCHAASLMAQHWDAGLASPGCLDPVWLN-------LPPITP A2BFQ0_DANRE A2BFQ0_DANRE RFAELEGYGSAFLGPANPGYCTAATLLAKNWNKGILSWGCLKAEMDE-EMYPTFLRPLPL Q4S8Y6_TETNG Q4S8Y6_TETNG RFAELEGYGAAYLGPANPGYCSSAALYAKEWDVGLLSWGCLNPNMKKVGMYPTYLQPLPL P87343_ORYLA P87343_ORYLA RFSDLEGYGAAFLGPANPGYCSSAALYTKEWDVGILSWGCLKPYMKTVDMFPTLLRPLPL Q9W616_ORYLA Q9W616_ORYLA RFSDLEGYGAAFLGPANPGYCSSAALYTKEWDVGILSWGCLKPYMKTVDMFPTFLRPLPL Q4T7P7_TETNG Q4T7P7_TETNG AFLGFHTKAAGYIGPANAGYCDAASMLSKGWNKAVFPWGCVGYELDDLRSHPTFAHSMPR Q7T3I2_ORYLA Q7T3I2_ORYLA TFVGFHTKASGYIGPVNPGYCDAASMLTKGWNKAVFPWACVGYDLDDVRSHPTLARSLPR Q9W615_ORYLA Q9W615_ORYLA TFVGFHTKASGYIGPVNPGYCDAASMLTKGWNKAVFPWACVGYELDDVRSHPTLARSLPR O57480_CHICK O57480_CHICK ALLGAERYAAGLVGPLNPAVCGAAELLAAAWNKPLVSWSCVG---DGEGERETLVEPMPA GUC2E_RAT GUC2E_RAT AVSSALTRVSGLVGPVNPAACRPAELLAQEAGVALVPWGC-----PGTRAAGTTAPAVTP Q8C8X5_MOUSE Q8C8X5_MOUSE AVSSALSRVSGLVGPVNPAACRPAELLAQEAGVALVPWGC-----PGTRAAGTTAPAVTP B1ASX7_MOUSE B1ASX7_MOUSE AVSSALSRVSGLVGPVNPAACRPAELLAQEAGVALVPWGC-----PGTRAAGTTAPAVTP GUC2E_MOUSE GUC2E_MOUSE AVSSALSRVSGLVGPVNPAGCRPAELLAQEAGVALVPWGC-----PGTRAAGTTAPAVTP GUC2D_HUMAN GUC2D_HUMAN AVSSALARVSGLVGPVNPAACRPAELLAEEAGIALVPWGC-----PWTQAEGTTAPAVTP GUC2D_BOVIN GUC2D_BOVIN AVSSALTRVSGLVGPVNPAACRPAELLAQEAGVALVPWGC-----PGTRAAGTTAPVVTP GUC2D_CANFA GUC2D_CANFA AVSSALGRVSGLVGPVNPAACRPAELLAQEAGVALVPWSC-----PGTRAGGTTAPAGTP GUC2F_BOVIN GUC2F_BOVIN SFISHHQMASGFIGPANPGYCEAASLLGNSWDKGIFSWACVNYELDSKNSHPTFSRTLPS GUC2F_HUMAN GUC2F_HUMAN SFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPS GUC2F_MOUSE GUC2F_MOUSE SFISHQQMASGFVGPANPGFCEAASLLGTSWDKGIFSWACVNHELDNKHSFPTFSRTLPS GUC2F_RAT GUC2F_RAT SFISHQQMASGFVGPANPGYCEAASLLGNSWDKGIFSWACVNHELDNKHSYPTFSRTLPS Q9PUK0_RANPI Q9PUK0_RANPI EFANFDKFSSAFIGPQNPGYCDAASLLGKNWDKAIFSWACINHELDMRDSFPTFARTMPT B3DHF2_DANRE B3DHF2_DANRE SFVQYENVADAFVGPTNPGYCNAAALMSKNWDKSLFSWACVNHELDRVQGYPTFARTLPS Q4SY29_TETNG Q4SY29_TETNG AFIYYEGMVDAFVGPINPGYCAAASLLSKNWDKALFSITCVNYELEHTVGFPTFARTLPI P87342_ORYLA P87342_ORYLA TFIYYDKSANAPVGPTNPGYCIAASLLAKSWDKALFSFSCISYELDRLTAYPTFARAAPF Q9W614_ORYLA Q9W614_ORYLA TFIYSDKSANALVGPTNPGYCIAASLLAKSWDKALFSFSCISYELDRLTAYPTFARAAPF MATCH . :** *. * .* : : . * . CONSENSUS ?????????????GP?NP??C??A?L?????????????C????????????T???????

GUC2D_RAT GUC2D_RAT MADVLLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGE-KGAT Q4TAT8_TETNG Q4TAT8_TETNG PTRVLFTVLRYFGWAHAAVVSAPTDLWESTGQEVAAGLRALGLPVGPVVTMERSGKGGAR P79999_ORYLA P79999_ORYLA PSKVLFTVLRFFRWAHVAVASAPTDLWESTAQEVASCLRAMGLPVGPVVSMETNSKDGAQ Q7T2Q2_ORYLA Q7T2Q2_ORYLA PSKVLFTVLRFFRWAHVAVVSAPTDLWESTAQEVASSLRAMGLPVGPVVSMETNSKDGAQ A2BFQ0_DANRE A2BFQ0_DANRE SSRVLFSVLRFFRWAHVGIVTAEGDMWEATGHELAASLRALGLPVGKVVTMEQDK-EGPR Q4S8Y6_TETNG Q4S8Y6_TETNG PSRVLFAVLRYFRWAHVSIISDETDLWEATGQELAASLRTLGLPVKPVVTMEDGK-EGAR P87343_ORYLA P87343_ORYLA SSNVLFTVLRYFRWAHVAIISEDTDLWEATGHELASSLRALGLPVNPVVTMETEK-DGPR Q9W616_ORYLA Q9W616_ORYLA SSNVLFTVLRYFRWAHVAIISEDTDLWEATGHELASSLRALGLPVNPVVTMETEK-DGPR Q4T7P7_TETNG Q4T7P7_TETNG PTSVLLSVVRYFRWAHIGIISSSDDIWVETANKVADALRSHGLPVRLVSFMENTP-HAIR Q7T3I2_ORYLA Q7T3I2_ORYLA PTWVLHNLLSYFRWAHIAIISSYEDIWVETAIKVADSLRSHGISVRLVSFMENTP-HGIR Q9W615_ORYLA Q9W615_ORYLA PTWVLHNLLSYFRWAHIAIISSYEDIWVETAIKVADSLRSHGISVRLVSFMENTP-HGIR O57480_CHICK O57480_CHICK PGAVLHAVLSYFRWAHVAVVTAPQDAWREVGRGLAQEMRARGPPVTVVTPVGTRE-EEAG GUC2E_RAT GUC2E_RAT AADALYVLLKAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALVTSMVPSDLSGAR Q8C8X5_MOUSE Q8C8X5_MOUSE AADALYVLLRAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALVTSMETSDRSGAR B1ASX7_MOUSE B1ASX7_MOUSE AADALYVLLRAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALVTSMETSDRSGAR GUC2E_MOUSE GUC2E_MOUSE AADALYVLLRAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALVTSMETSDRSGAR GUC2D_HUMAN GUC2D_HUMAN AADALYALLRAFGWARVALVTAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAR GUC2D_BOVIN GUC2D_BOVIN AADALYALLRAFRWAHVALVTAPQDLWVEAGHALSTALRARGLPVALVTSMEPSDLSGAR GUC2D_CANFA GUC2D_CANFA AADALYALLRAFRWARVALITAPQDLWVEAGRALSAALRARGLPVALVTTMEPSDLSGAR GUC2F_BOVIN GUC2F_BOVIN PIRVLLTVMKYFQWAHAGVISSDEDIWVHTAYRVASALRSRGLPVGVVLTTGQDS-QSIQ GUC2F_HUMAN GUC2F_HUMAN PIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDS-QSMR GUC2F_MOUSE GUC2F_MOUSE PIRVLVTVMKYFQWAHAGVISSDEDIWMHTANRVSSALRSQGLPVGVVLTSGRDS-QSIQ GUC2F_RAT GUC2F_RAT PIRVLVTVMKYFQWAHAGVISSDEDIWVHTANQVSSALRSHGLPVGVVLTSGQDS-RSIQ Q9PUK0_RANPI Q9PUK0_RANPI PNKVLFLFMKYFRWAHVAVVSSNEDIWVDTGRKVASALRNQGLPIGIVTNMGNGE-RGLI B3DHF2_DANRE B3DHF2_DANRE PLRVLFNVLKFFRWANIGIVSSNEDIWIDTAAKLASALRNRGLPVGIVTSMGNND-TMLE Q4SY29_TETNG Q4SY29_TETNG SVDVLFNVLKHFRWANVAVVSSNEDIWRDTAGRVSTALRDRGLPVSLVTSMGMNK-TEVE P87342_ORYLA P87342_ORYLA PADVLFTVFKHYRWATSVVISSNEEIWIETAGRVASALRMKGLPVGFVAAMGMND-TELE Q9W614_ORYLA Q9W614_ORYLA PADVLFTVFKHYRWATSVVISSNEEIWIETAGRVASALRMKGLPVGFVAAMGMND-TELE MATCH .* .. : ** : : : * .. :: :* * .: : CONSENSUS ????L??????F?WA?????????D?W??????????LR??GLPV??V????????????

GUC2D_RAT GUC2D_RAT EVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLRCAREEGLTDGRLVFLPYDTLLFALPY Q4TAT8_TETNG Q4TAT8_TETNG EALKRIQGADRVKVVIMCMSSLLIGGEDQRQLLLDALEMGMVSDGYVFIPYDALLYAMPY P79999_ORYLA P79999_ORYLA EALYQVKTADKVNVIIMCMSSVLIGGEHQRELLLTALDMGMISDGYVFIPYDALLYAMPY Q7T2Q2_ORYLA Q7T2Q2_ORYLA EALYQVKTADKVNVIIMCMSSVLIGGEHQRELLLTALDMGMISDGYVFIPYDALLYAMPY A2BFQ0_DANRE A2BFQ0_DANRE QALQAIRDTDRVRVVIMCMHSALIGGEEQYQLLTTALEMRMIDRGYIFIPYDTLLYSLPY Q4S8Y6_TETNG Q4S8Y6_TETNG RALTKVRETDRVRVVIMCMPSVLIGGQTQYHLLTTALAMRMIDRGYIFIPYDTLLYSLPY P87343_ORYLA P87343_ORYLA SALAKVREADRVRVIIMCMPSVLIGGQAQYQLLTTALAMRMIDRGYVFIPYDTLLYSLPY Q9W616_ORYLA Q9W616_ORYLA SALAKVREADRVRVIIMCMPSVLIGGQAQYQLLTTALAMRMIDRGYVFIPYDTLLYSLPY Q4T7P7_TETNG Q4T7P7_TETNG HTLSKVRKMKELRVVILCMHSVLIGGEVQKLLLETAYDMEMIDGSFVFVPYDTLLYSLPY Q7T3I2_ORYLA Q7T3I2_ORYLA QTLSRVHKMQEIRAVILCMHSALIGGSAQKLLLEAAYDMKMTDGSLVFVPYDTLLYSLPH Q9W615_ORYLA Q9W615_ORYLA QTLSRVHKMQEIRAVILCMHSALIGGSAQKLLLEAAYDMKMTDGSLVFVPYDTLLYSLPH O57480_CHICK O57480_CHICK EALRRVRRADGVRVVVMCMHSVLLGGEEQRVLLEKAEDMGMTDGTYVFIPYDALTFPLPY GUC2E_RAT GUC2E_RAT EALRRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTLHYALSP Q8C8X5_MOUSE Q8C8X5_MOUSE EALGRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTLHYALSP B1ASX7_MOUSE B1ASX7_MOUSE EALGRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTLHYALSP GUC2E_MOUSE GUC2E_MOUSE EALGRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTLHYALSP GUC2D_HUMAN GUC2D_HUMAN EALRKVRDGPRVTAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYALSP GUC2D_BOVIN GUC2D_BOVIN EALRRVQDGPRVRAVIMVMHSVLLGGEEQRCLLEAAEELGLADGSLVFLPFDTLHYALSP GUC2D_CANFA GUC2D_CANFA EALRRVQDGPRVRAVIMVMHSVLLGGEEQRCLLQAAEELGLADGSLVFLPFDTLHYALSP GUC2F_BOVIN GUC2F_BOVIN KALQQIRQADRIRIIIMCMHSTLIGGETQTHLLEWAHDLQMTDGTYVFVPYDTLLYSLPY GUC2F_HUMAN GUC2F_HUMAN KALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPY GUC2F_MOUSE GUC2F_MOUSE KALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTDGTYVFVPYDVLLYSLPY GUC2F_RAT GUC2F_RAT KALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTDGTYVFVPYDVLLYSLPY Q9PUK0_RANPI Q9PUK0_RANPI DTLTAIRTCMISESSIMCMHSVFIGGEEQAIFLIKAHEMGLTDGRYVFVPYDTLLYSLPY B3DHF2_DANRE B3DHF2_DANRE NTLMSIKNAGDIKVIIMCMHSVLIGGEQQATFLTKAYDMGLASGRYVFIPYDTLLYSLPY Q4SY29_TETNG Q4SY29_TETNG SSLRNIQNAGGVRVIIMCMHSVLVGGEQQATFLLKAKEMGLTGGQYVFVPYDTLHYSVPY P87342_ORYLA P87342_ORYLA STLKKIQSTGGVRVIIMCIDSVLVGGEQQAVFLLKAKQLGLTSGKYVFVPYDTLHYSVPY Q9W614_ORYLA Q9W614_ORYLA STLKKIQSTGGVRVIIMCMHSVLVGGEQQAVFLLKAKQLGLTSGKYVFVPYDTLHYSVPY MATCH :: :: : * ::** * :* * : . :*:*:*.: :.:. CONSENSUS ??L????????????IM?M?S?L?GG??Q???L??A??????????VF?P?D?L?Y????

GUC2D_RAT GUC2D_RAT -----------------------------RNRSYLVLDDDGPLQEAYDAVLTISLDTSPE Q4TAT8_TETNG Q4TAT8_TETNG QVTPVLQPPALPVLPGGAESGLSFSFPSNQDTAFPQLTNSTQLRHAYSSVLTVTMAS--E P79999_ORYLA P79999_ORYLA -----------------------------QDMTFHQLTNSTQLRHAYSAVLTVTMES--D Q7T2Q2_ORYLA Q7T2Q2_ORYLA -----------------------------QDMTFHQLTNSTQLRHAYSAVLTVTMES--D A2BFQ0_DANRE A2BFQ0_DANRE -----------------------------ENVKYPILANDSKLRRAYDGVLTVTMDQG-E Q4S8Y6_TETNG Q4S8Y6_TETNG -----------------------------KNAQYYSLGNDTKLRKAYDGVLTITMDSG-E P87343_ORYLA P87343_ORYLA -----------------------------KDAFYYMLGNDTKLRRAFDGVLTITMESG-E Q9W616_ORYLA Q9W616_ORYLA -----------------------------KDAFYYMLGNDTKLRRAFDGVLTITMESG-E Q4T7P7_TETNG Q4T7P7_TETNG -----------------------------RNVTYAALKSNGKLLRAYDAVLTVTIDSP-R Q7T3I2_ORYLA Q7T3I2_ORYLA -----------------------------RNITYPALKSNSKLLRAYDAVLTVTIDSP-H Q9W615_ORYLA Q9W615_ORYLA -----------------------------RNITYPALKSNSKLLRAYDAVLTVTIDSP-H O57480_CHICK O57480_CHICK -----------------------------HRVPYPILANSTKLRLAYDAVLTITIDSP-E GUC2E_RAT GUC2E_RAT -----------------------------GPEALAAFVNSSKLRRAHDAVLTLTRRCPPG Q8C8X5_MOUSE Q8C8X5_MOUSE -----------------------------GPEALAAFVNSSQLRRAHDAVLTLTRRCPPG B1ASX7_MOUSE B1ASX7_MOUSE -----------------------------GPEALAAFVNSSQLRRAHDAVLTLTRRCPPG GUC2E_MOUSE GUC2E_MOUSE -----------------------------GPEALAAFVNSSQLRRAHDAVLTLTRRCPPG GUC2D_HUMAN GUC2D_HUMAN -----------------------------GPEALAALANSSQLRRAHDAVLTLTRHCPSE GUC2D_BOVIN GUC2D_BOVIN -----------------------------GPDALAVLANSSQLRKAHDAVLTLTRHCPLG GUC2D_CANFA GUC2D_CANFA -----------------------------GPEALAVLANSSQLRRAHDAVLILTRHCPPG GUC2F_BOVIN GUC2F_BOVIN -----------------------------KHTPYKVLRNNPKLREAYDAVLTITVESQ-E GUC2F_HUMAN GUC2F_HUMAN -----------------------------KHTPYQVLRNNPKLREAYDAVLTITVESQ-E GUC2F_MOUSE GUC2F_MOUSE -----------------------------KHSPYQVLRNNPKLREAYDAVLTITVESH-E GUC2F_RAT GUC2F_RAT -----------------------------KHSPYQVLRNNQKLREAYDAVLTITVESH-E Q9PUK0_RANPI Q9PUK0_RANPI -----------------------------KNNSYPIFDKNSTLHAAYDAVLTITMDYE-E B3DHF2_DANRE B3DHF2_DANRE -----------------------------INITYYPLQNNSKLSKAYDAVLTITLDSD-I Q4SY29_TETNG Q4SY29_TETNG -----------------------------NNVSHKPLQSNSQLREAYDAVLTITVASE-P P87342_ORYLA P87342_ORYLA -----------------------------TNVSHFALKNNSSLKEAYDAVLTITMASE-P Q9W614_ORYLA Q9W614_ORYLA -----------------------------TNVSHFALKNNSSLKEAYDAVLTITMASE-P MATCH : .. * *...** :: CONSENSUS ????????????????????????????????????L?????L??A?DAVLT?T??????

GUC2D_RAT GUC2D_RAT S---HAFTATKMRGGAAANLGPEQ-------VSPLFGTIYDAVILLAHALNHSETH--GT Q4TAT8_TETNG Q4TAT8_TETNG QSFYEAFREMQINREIRSAVAVTQ-------VSPLFGTIFNMVYFIAKSVEERRQAGGGR P79999_ORYLA P79999_ORYLA QNFYQAFRQAQMSREIRSAISATE-------VSPVFGTIFNMVYFVAKAVEERRLAGGGH Q7T2Q2_ORYLA Q7T2Q2_ORYLA QNFYQAFRQAQMSREIRSAISATE-------VSPVFGTIFNMVYFVAKAVEERRLAGGGH A2BFQ0_DANRE A2BFQ0_DANRE QNFYEAFNAAQESFEIRGSTSAEE-------VSPFFGTIYNMIYYTAMAAEQSRASSGGR Q4S8Y6_TETNG Q4S8Y6_TETNG RNFYEAFKDAQDSYEIRSSTNPEQARPLNTEVSPFFGTIYNMMYYIAMAAEQARAN-GGH P87343_ORYLA P87343_ORYLA RNFYEAFKDAQDRFELRSSTPTEQ-------VSPFFGTIYNMMYYIAMAVEQTRAS-GVH Q9W616_ORYLA Q9W616_ORYLA RNFYEAFKDAQDRFELRSSTPAEQ-------VSPFFGTIYNMMYYIAMAVEQTRAS-GVH Q4T7P7_TETNG Q4T7P7_TETNG MSFYESYREAMEKREVAATLKPQE-------VSPLFGTIYNSIFFMAHAVHHLRQS--GE Q7T3I2_ORYLA Q7T3I2_ORYLA TSFYETYREVMERGEVPTTLKPQQ-------VSPMFGTIYNSVLLMAHAIKGVRDS--GA Q9W615_ORYLA Q9W615_ORYLA TSFYETYREVMERGEVPTTLKPQQ-------VSPMFGTIYNSVLLMAHAIKGVRDS--GA O57480_CHICK O57480_CHICK VSFHEALRQAQEAYEIPAHIDPTQ-------VHPLFATIYNSIYFLANAVEATRRS--GR GUC2E_RAT GUC2E_RAT GSVQDSLRRAQEHQELPLDLDLKQ-------VSPLFGTIYDAVFLLAGGVTRARAAVGGG Q8C8X5_MOUSE Q8C8X5_MOUSE GSVQDSLRRAQEHQELPLDLNLKQ-------VSPLFGTIYDAVFLLAGGVKRARTAVGGG B1ASX7_MOUSE B1ASX7_MOUSE GSVQDSLRRAQEHQELPLDLNLKQ-------VSPLFGTIYDAVFLLAGGVKRARTAVGGG GUC2E_MOUSE GUC2E_MOUSE GSVQDSLRRAQEHQELPLDLNLKQ-------VSPLFGTIYDAVFLLAGGVKRARTAVGGG GUC2D_HUMAN GUC2D_HUMAN GSVLDSLRRAQERRELPSDLNLQQ-------VSPLFGTIYDAVFLLARGVAEARAAAGGR GUC2D_BOVIN GUC2D_BOVIN GSVRDSLRRAQEHRELPLDLNLQQ-------VSPLFGTIYDSVFLLAGGVARARVAAGGG GUC2D_CANFA GUC2D_CANFA GSVMDNLRRAQEHQELPSDLDLQQ-------VSPFFGTIYDAVLLLAGGVARARAAAGGG GUC2F_BOVIN GUC2F_BOVIN KTFYQAFEEAAARGEIPEKLESDQ-------VSPLFGTIYNSIYFIAQAMNNAMKE--NG GUC2F_HUMAN GUC2F_HUMAN KTFYQAFTEAAARGEIPEKLEFDQ-------VSPLFGTIYNSIYFIAQAMNNAMKE--NG GUC2F_MOUSE GUC2F_MOUSE KTFYEAYAEAAARGEIPEKPDSNQ-------VSPLFGTIYNSIYFIAQAMNNAMKK--NG GUC2F_RAT GUC2F_RAT KTFYEAFTEAAAGGEIPEKLDSHQ-------VSPLFGTIYNSIYFIAQAMSNALKE--NG Q9PUK0_RANPI Q9PUK0_RANPI KSFYEVFAELKEKGEIKTNLEPQQ-------VSPLFGTIYNSMYLLAKAMSSAWKQ--GA B3DHF2_DANRE B3DHF2_DANRE MTFNEAFNAAKQLGELMVTQEPEQ-------VSPLFGTIYNSLYLLAKSMHNARRA--GR Q4SY29_TETNG Q4SY29_TETNG LSFNEAFAAAKENQEVTLDVRPEQ-------VHPLFGTIYNSIYILARSIHNTRKG--GM P87342_ORYLA P87342_ORYLA LSFNEAFEAARKSGEITLPVQPEQ-------VNPLFGTIYNSIYLMARSIHNARKA--GM Q9W614_ORYLA Q9W614_ORYLA LSFNEAFEAARKSGEITLPVQPEQ-------VNPLFGTIYNSIYLMARSIHNARKA--GM MATCH . : * *.*.**:: : * . CONSENSUS ?????????A????E????????Q???????VSP?FGTIY??????A?????????????

GUC2D_RAT GUC2D_RAT GLSGAHLGNHIRALDVAGFSQRIRIDGKGRRL-PQYVILDTNGEGSQLVPTHILDVS--- Q4TAT8_TETNG Q4TAT8_TETNG WVTGNQLVHSDGGFEFQGFNQLLYGGSEGQGLQAKYVVLDSD--GDRLVPTHSLAPSHSA P79999_ORYLA P79999_ORYLA WVTGSQLFQSDGGFEFQGFNQVLYGGKGGRGLQARYVVLDSE--GDRLVPTHSLAPTHTD Q7T2Q2_ORYLA Q7T2Q2_ORYLA WVTGSQLFQSDGGFEFQGFNQVLYGGKGGRGLQARYVVLDSE--GDRLVPTHSLAPTHTD A2BFQ0_DANRE A2BFQ0_DANRE WVSGDLLSQNEGGFEFDGFNQRISGGTNGEGMQVRYAVLDSDGSGSSLYRTHALEASHTY Q4S8Y6_TETNG Q4S8Y6_TETNG WVTGHILGESKGGFEFEGFNQPLRAGRNSQGMQARYVVLDYSGMGTSLYSTHTLEPSHTD P87343_ORYLA P87343_ORYLA WVTGRSLGNSEGGFEFEGFNQPLQAGRNGEGMQAGYVVLDYSGMGNSLYSTHLLHPTHTD Q9W616_ORYLA Q9W616_ORYLA WVTGRSLGNSEGGFEFEGFNQPLQAGRNGEGMQAGYVVLDYSGMGNSLYSTHFLHPTHTD Q4T7P7_TETNG Q4T7P7_TETNG WMSGGNLARRTRNLAIQGFSHWLRTNASGSAL-VDYLILDTDGLSWELKPVYRIDME--- Q7T3I2_ORYLA Q7T3I2_ORYLA WISGGNLAHQTRNLNFQGFSHRIKTSSSGAVQ-LDYLILDTDGSSSELLPTYRIDME--- Q9W615_ORYLA Q9W615_ORYLA WISGGNLAHQTRNLNFQGFSHRIKTSSSGAVQ-LDYLILDTDGSSSELLPTYRIDME--- O57480_CHICK O57480_CHICK WVMGSSVAENARDFQMEGFCQPFSVTEDGDVN-VPYVVLDTDGKGDRLWPVYGLEPG--- GUC2E_RAT GUC2E_RAT WVSGASVARQMREAQVFGFCGIL-----GRTEEPSFVLLDTDAAGERLFTTHLLDPV--- Q8C8X5_MOUSE Q8C8X5_MOUSE WVSGASVARQVREAQVSGFCGVL-----GRTEEPSFVLLDTDASGEQLFATHLLDPV--- B1ASX7_MOUSE B1ASX7_MOUSE WVSGASVARQVREAQVSGFCGVL-----GRTEEPSFVLLDTDASGEQLFATHLLDPV--- GUC2E_MOUSE GUC2E_MOUSE WVSGASVARQVREAQVSGFCGVL-----GRTEEPSFVLLDTDASGEQLFATHLLDPV--- GUC2D_HUMAN GUC2D_HUMAN WVSGAAVARHIRDAQVPGFCGDL-----GGDEEPPFVLLDTDAAGDRLFATYMLDPA--- GUC2D_BOVIN GUC2D_BOVIN WVSGAAVARHIRDARVPGFCGAL-----GGAEEPSFVLLDTDATGDQLFATYVLDPT--- GUC2D_CANFA GUC2D_CANFA WVSGATVAHHIPDAQVPGFCGTL-----GGAQEPPFVLLDTDAAGDRLFATYMLDPT--- GUC2F_BOVIN GUC2F_BOVIN WASAASLVQHSRNVQFYGFNQLIRTDANGNGI-SEYVILDTNWKEWELHSTYTVDME--- GUC2F_HUMAN GUC2F_HUMAN QAGAASLVQHSRNMQFHGFNQLMRTDSNGNGI-SEYVILDTNLKEWELHSTYTVDME--- GUC2F_MOUSE GUC2F_MOUSE RASAASLVQHSRNMQFYGFNQLIKTDSNGNGI-SEYVILDTNGKEWELRGTYTVDME--- GUC2F_RAT GUC2F_RAT QASAASLTRHSRNMQFYGFNQLIRTDSNGNGI-SEYVILDTNGKEWELRGTYTVDME--- Q9PUK0_RANPI Q9PUK0_RANPI WISGTNLVEYTKNLDYPGFTHMLYTDGKGNGL-SSFVVLDTDGKINQLFPTYSVEVG--- B3DHF2_DANRE B3DHF2_DANRE WLSGTNLAYFTRNITFTGFNQDIQTDEQGNGQ-TNYVILDTEAWGTQLYRCFLVDMT--- Q4SY29_TETNG Q4SY29_TETNG SLSGSNLAYFTKNIDFTGFNQNVKVDSQGQIR-SSYVVLDTDSTGSHLYRTYTVDLV--- P87342_ORYLA P87342_ORYLA TLSGSNVAYYTKNTNFDGFNQRFEVDSRGQVK-TSYVVLDSDSKGAELYQAYVVDLR--- Q9W614_ORYLA Q9W614_ORYLA TLSGSNVAYYTKNTNFDGFNQRFEVDSRGQVK-TSYVVLDSDSKGAELYQAYVVDLR--- MATCH . : ** . . : :** . * . : CONSENSUS ???G?????????????GF?????????G???????V?LD???????L??T?????????

GUC2D_RAT GUC2D_RAT --TQQVQPLGTAVHFP-GGSPPAHDASCWFDPNTLCIRG-----VQPLGSLLTLTITCVL Q4TAT8_TETNG Q4TAT8_TETNG GELGGLRPLGRSFIFP--GGRPSKDSFCWFSPDEACTGG-----MDATTMFSVFVLVCLL P79999_ORYLA P79999_ORYLA GTVGGLRPLGRSFFFP--GGKPSKSSFCWFSPEEACSGG-----LDAVSLFFILLLLCAV Q7T2Q2_ORYLA Q7T2Q2_ORYLA GTVGGLRPLGRSFFFP--GGKPSKSSFCWFSPEEACSGG-----LDAVSLFFILLLLCAV A2BFQ0_DANRE A2BFQ0_DANRE GKYGGLKYLGKSIHFA--GASPSSDANCWFSPYIACSGGNKNNRLDGVTLFFLLMFFIVL Q4S8Y6_TETNG Q4S8Y6_TETNG GITGGLKYLGRSIHFA--GSTPYTDSSCWFSPYFACSGG-----MDSVTLLFLLLLLIAL P87343_ORYLA P87343_ORYLA TMTGGLRYLGRSVHFA--GSTPYTDSSCWFSPYFACSGG-----WDSTTAFFVFVLLILF Q9W616_ORYLA Q9W616_ORYLA TMTGGLRYLGRSVHFA--GSTPYTDSSCWFSPYFACSGG-----WDSTTAFFVFVLLILF Q4T7P7_TETNG Q4T7P7_TETNG --AGSVRFLGRDIHFP-RGFGPRRDSSCWFTPGVICSGG-----VDLFLTVAIFCGAITA Q7T3I2_ORYLA Q7T3I2_ORYLA --IGMVRFLGRDIHFP-HGYGPRRDAACWFIPGVICSGG-----VDLFLTFSTFLGSIAV Q9W615_ORYLA Q9W615_ORYLA --IGMVRFLGRDIHFP-HGYGPRRDAACWFIPGVICSGG-----VDLFLTFSTFLGSIAV O57480_CHICK O57480_CHICK --IRGLAYRGHSVHWP-HSSSPGTDSGCWFESGSICNGG-----MDASFVLLIFILVSAL GUC2E_RAT GUC2E_RAT --LGSLRSAGTPVHFPRGAPAPGPDPSCWFDPDVICNGG-----VEPGLVFVGFLLVIVV Q8C8X5_MOUSE Q8C8X5_MOUSE --LGSLRSAGTPMHFPRGGPAPGPDPSCWFDPDVICNGG-----VEPGLVFVGFLLVIGM B1ASX7_MOUSE B1ASX7_MOUSE --LGSLRSAGTPMHFPRGGPAPGPDPSCWFDPDVICNGG-----VEPGLVFVGFLLVIGM GUC2E_MOUSE GUC2E_MOUSE --LGSLRSAGTPMHFPRGGPAPGPDPSCWFDPDVICNGG-----VEPGLVFVGFLLVIGM GUC2D_HUMAN GUC2D_HUMAN --RGSFLSAGTRMHFPRGGSAPGPDPSCWFDPNNICGGG-----LEPGLVFLGFLLVVGM GUC2D_BOVIN GUC2D_BOVIN --QGFFHSAGTPVHFPKGGRGPGPDPSCWFDPDTICNGG-----VEPSVVFIGFLLVVGM GUC2D_CANFA GUC2D_CANFA --RGSLLSAGTPVHFPRGGGTPGSDPSCWFEPGVICNGG-----VEPGLVFLGFLLVVGM GUC2F_BOVIN GUC2F_BOVIN --TELLRFGETPIHFP-GGRPPRADAQCWFADGRICQGG-----INPTFALMVCLALLIA GUC2F_HUMAN GUC2F_HUMAN --MELLRFGGTPIHFP-GGRPPRADAKCWFAEGKICHGG-----IDPAFAMMVCLTLLIA GUC2F_MOUSE GUC2F_MOUSE --TELLRFRGTPIHFP-GGRPTSADAKCWFAERKICQGG-----IDPALAMMVCFALLIA GUC2F_RAT GUC2F_RAT --TELLRFRGTPIHFP-GGRPTSADAKCWFAQGKICQGG-----IDPALAMMVCFALLLA Q9PUK0_RANPI Q9PUK0_RANPI --INLVRFLGKTIRFP-GGTPPTADSSCWFDPDTLCIGG-----IEPSIVILVFGLVFAL B3DHF2_DANRE B3DHF2_DANRE --SDLVLFAGRFIHFP-GESPPPSDSRCWFEDNAICTGG-----VDIIYVIIAFVIVLII Q4SY29_TETNG Q4SY29_TETNG --SQRLRFAGRSINFP-GGSPPSSDSICWFDKNIICTGG-----VEITYIVVIFAVLFAL P87342_ORYLA P87342_ORYLA --SGVLRFTGRSIHFP-GGSPPVADSSCWFEENAVCTGG-----VEVTYIIIVLAVILSM Q9W614_ORYLA Q9W614_ORYLA --SGVLRFTGRSIHFP-GGSPPVADSSCWFEENAVCTGG-----VEVTYIIIVLAVILSM MATCH . . :. . .. *** * * : . CONSENSUS ?????????G???HFP??G??P??D??CWF?????C?GG?????????????????????

GUC2D_RAT GUC2D_RAT ALVGGFLAYFIRL--GLQQLRLLRG----PHRILLTPQELTFLQRTPSRRR-----PH-- Q4TAT8_TETNG Q4TAT8_TETNG VAASLYWFRKYRR--AQSI-----------AKIVLTLDNIVFIDTQVSRKVSAGGPAATT P79999_ORYLA P79999_ORYLA IAASFFWIRKYKK--SANL-----------AKLILTLDDIVFIDTQVSRKK--------- Q7T2Q2_ORYLA Q7T2Q2_ORYLA IAASFFWIRKYKK--SANL-----------AKLILTLDDIVFIDTQVSRKK--------- A2BFQ0_DANRE A2BFQ0_DANRE IAGAGILFLQVRKYGAGGFFGAFIGGGGSPTKIVLTLDDLVFINTTLSRRK--------- Q4S8Y6_TETNG Q4S8Y6_TETNG AGVGANFFFAFKRHGRVGFSFGGGGGG--AAKVVLTLDDLIFINTQISKRVSPK------ P87343_ORYLA P87343_ORYLA AGFGANIILRFKREGRVGFSFGGDGNGG-PSKVVLTLDDLVLINTQVSKRK--------- Q9W616_ORYLA Q9W616_ORYLA AGFGANIILRFKREGRVGFSFGGDGNGG-PSKVVLTLDDLVFINTQVSKRK--------- Q4T7P7_TETNG Q4T7P7_TETNG IVFTVALIYCVRR--RINQIRMVRG----PNKILLTLDDVTFINPSLSNKVSPFFNLD-- Q7T3I2_ORYLA Q7T3I2_ORYLA ALFLIALLYCIRR--RINQIRLVRG----PNKILLTLTDVTFINPSLSNKK---LSLD-- Q9W615_ORYLA Q9W615_ORYLA ALFLIALLYCIRR--RINQIRLVRG----PNKILLTLTDVTFINPSLSNKK---LSLD-- O57480_CHICK O57480_CHICK VAAGAALACFIRR--RIQQAQLMKG----PNKIILTMEDLTFINTQSNKRV--------- GUC2E_RAT GUC2E_RAT GLTGAFLAHYLRH--RLLHMQMVSG----PNKIILTLEDVTFLHPQGGSSR--------- Q8C8X5_MOUSE Q8C8X5_MOUSE GLTGAFLAHYLRH--RLLHMQMASG----PNKIILTLEDVTFLHPPGGSSR--------- B1ASX7_MOUSE B1ASX7_MOUSE GLTGAFLAHYLRH--RLLHMQMASG----PNKIILTLEDVTFLHPPGGSSR--------- GUC2E_MOUSE GUC2E_MOUSE GLTGAFLAHYLRH--RLLHMQMASG----PNKIILTLEDVTFLHPPGGSSR--------- GUC2D_HUMAN GUC2D_HUMAN GLAGAFLAHYVRH--RLLHMQMVSG----PNKIILTVDDITFLHPHGGTSR--------- GUC2D_BOVIN GUC2D_BOVIN GLAGAFLAHYCRH--RLLHIQMVSG----PNKIILTLDDITFLHPHGGNSR--------- GUC2D_CANFA GUC2D_CANFA GLTGAFLAHYLRH--RLLHIQMVSG----PNKIILTLDDVTFLHPHGGSTR--------- GUC2F_BOVIN GUC2F_BOVIN LLSINGFAYFIRH--RINKIQLIKG----PNRILLTLEDVTFINPHFGSKRGSHASVS-- GUC2F_HUMAN GUC2F_HUMAN LLSINGFAYFIRR--RINKIQLIKG----PNRILLTLEDVTFINPHFGSKRGSRASVS-- GUC2F_MOUSE GUC2F_MOUSE LLSINGFAYFIRR--RINKIQLIKG----PNRILLTLEDVTFINPHFGSKRGSRASVS-- GUC2F_RAT GUC2F_RAT LLSINGFAYFIRR--RINKIQLIKG----PNRILLTLEDVTFINPHFGSKRGSRASVS-- Q9PUK0_RANPI Q9PUK0_RANPI ALCGVGVSYLIRH--SLLQIQLVKG----PNKILLSLDDLTFINPKLSMKK-----IN-- B3DHF2_DANRE B3DHF2_DANRE VLGSIGLSLFIRR--RIQQIQLIKG----PNRILLTLEDLTFINPQLSKRK-----IT-- Q4SY29_TETNG Q4SY29_TETNG AIGGLIISLFIRR--RLQQIQLVKG----PNRILLTLEDLTFINPQLSKKK-----IT-- P87342_ORYLA P87342_ORYLA TVGGFFIGPYTRR--RLQQIQLVKG----PNRILLTLEDLTFINPQLSKKE-----IT-- Q9W614_ORYLA Q9W614_ORYLA TVGGFFIGLYIRR--RLQQIQLVKG----PNRILLTLEDLTFINPQLSKKK-----IT-- MATCH : :::*: :: ::. . CONSENSUS ???????????R????????????G????P??I?LTL?D??F??????????????????

GUC2D_RAT GUC2D_RAT ---------------------VDSGSESRSVVDGG---SPQSVIQGSTRSVPAFLEHTNV Q4TAT8_TETNG Q4TAT8_TETNG LAPGQMLAAVGHVLPLFSLKKLNDESIMRSLLEIK----TPVRSAARS-YILTSPDSSNV P79999_ORYLA P79999_ORYLA ---------------------LNDESIMRSLLEIK----TPLRSIARS-YILTTPESSNI Q7T2Q2_ORYLA Q7T2Q2_ORYLA ---------------------LNDESIMRSLLEIK----TPLRSIARS-YILTTPESSNI A2BFQ0_DANRE A2BFQ0_DANRE ---------------------LNDESMLKSQLDVK---TPRHSVSGRS-YITSTPETSNV Q4S8Y6_TETNG Q4S8Y6_TETNG ---------------------SDFFFFFLSQLDIK---TPHHSVSGRS-YLASSPDSSNV P87343_ORYLA P87343_ORYLA ---------------------LNDESIVKSQMDLK---TPHHSVSGRS-YLASTPDSSNI Q9W616_ORYLA Q9W616_ORYLA ---------------------LNDESIVKSQMDLK---TPHHSVSGRS-YLASTPDSSNI Q4T7P7_TETNG Q4T7P7_TETNG ---------------------DSRASGMRSISERS----VVSPVSTKS-P--ATHENSNV Q7T3I2_ORYLA Q7T3I2_ORYLA ---------------------DSRTSGGRSLSECS----QNTPLSSQS-P--ATYENSNI Q9W615_ORYLA Q9W615_ORYLA ---------------------DSRTSGGRSLSECS----QNTPLSSQS-P--ATYENSNI O57480_CHICK O57480_CHICK -------------------------DGSRTSLAGR----STGDTKSIR-SVTAAPDTTNV GUC2E_RAT GUC2E_RAT ----------------------KVAQGSRSSLATR----STSDIRSVP-S--QPQESTNI Q8C8X5_MOUSE Q8C8X5_MOUSE ----------------------KVVQGSRSSLATR----SASDIRSVP-S--QPQESTNV B1ASX7_MOUSE B1ASX7_MOUSE ----------------------KVVQGSRSSLATR----SASDIRSVP-S--QPQESTNV GUC2E_MOUSE GUC2E_MOUSE ----------------------KVVQGSRSSLATR----SASDIRSVP-S--QPQESTNV GUC2D_HUMAN GUC2D_HUMAN ----------------------KVAQGSRSSLGAR----SMSDIRSGP-S--QHLDSPNI GUC2D_BOVIN GUC2D_BOVIN ----------------------KVAQGSRTSLAAR----SISDVRSIH-S--QLPDYTNI GUC2D_CANFA GUC2D_CANFA ----------------------KVVQGSRSSLAAR----STSDIRSVP-S--QPLDNSNI GUC2F_BOVIN GUC2F_BOVIN ---------------------FQITSEVQSGRSPR----LSFSSGSLT-P--ATCENSNI GUC2F_HUMAN GUC2F_HUMAN ---------------------FQITSEVQSGRSPR----LSFSSGSLT-P--ATYENSNI GUC2F_MOUSE GUC2F_MOUSE ---------------------FQIISEVQSGRSPR----LSFSSGSLT-P--ATYENSNI GUC2F_RAT GUC2F_RAT ---------------------FQIISEVQSGRSPR----LSFSSGSLT-P--ATYENSNI Q9PUK0_RANPI Q9PUK0_RANPI ---------------------IDNISDTKSVSDCRSLKSIARSLSTKS-A--VNHENSNV B3DHF2_DANRE B3DHF2_DANRE ---------------------LEDLSDSKSYIEEKSTGDRSRSVNSMA-T--ATHETSNV Q4SY29_TETNG Q4SY29_TETNG ---------------------LEDLSESKSGLEEKSA-DHSHSVNSIQ-T--ASHETTNV P87342_ORYLA P87342_ORYLA ---------------------LDDLSESKSALDDKSA-DPSHSMNSMQ-T--AIHENSSV Q9W614_ORYLA Q9W614_ORYLA ---------------------LDDLSESKSALDDKSA-DPSHSMNSMQ-T--ATHENSSV MATCH : : ..: CONSENSUS ?????????????????????????????S????????????????????????????N?

GUC2D_RAT GUC2D_RAT ALYQ----------------------------------GEWVWLKKFEAGTA---PDLRP Q4TAT8_TETNG Q4TAT8_TETNG GILE----------------------------------GDWVWLKKIPVGRT--LPAVNH P79999_ORYLA P79999_ORYLA GILE----------------------------------GDWVWLKKIPIGKT--TTAVNQ Q7T2Q2_ORYLA Q7T2Q2_ORYLA GILE----------------------------------GDWVWLKKIPIGKT--TTAVNQ A2BFQ0_DANRE A2BFQ0_DANRE AVFEVWEICEFLCTGIVFGSMMKQYYMRKCDFLTGYQKGDWVWLKKCPCADS--ITEISE Q4S8Y6_TETNG Q4S8Y6_TETNG AVFE----------------------------------GDWVWLKKCPSGVV---SSVNS P87343_ORYLA P87343_ORYLA AVYE----------------------------------GDLVWLKKCPTGSV---SSVSS Q9W616_ORYLA Q9W616_ORYLA AVYE----------------------------------GDWVWLKKCPTGSV---SSVSS Q4T7P7_TETNG Q4T7P7_TETNG VIYE----------------------------------GDWAWLKRLLDGRF---SNISP Q7T3I2_ORYLA Q7T3I2_ORYLA VIYE----------------------------------GDWAWLKRLPNGNF---GSINP Q9W615_ORYLA Q9W615_ORYLA VIYE----------------------------------GDWAWLKRLPNGNF---GSINP O57480_CHICK O57480_CHICK AIAEGNETPPGANSHLPL-----LLLLFNQQGLVASVQGDWVWLKKFPGDQH---SEVKP GUC2E_RAT GUC2E_RAT GLYE----------------------------------GDWVWLKKFPGEHH---MAIRP Q8C8X5_MOUSE Q8C8X5_MOUSE GLYE----------------------------------GDWVWLKKFPGEHH---MAIRP B1ASX7_MOUSE B1ASX7_MOUSE GLYE----------------------------------GDWVWLKKFPGEHH---MAIRP GUC2E_MOUSE GUC2E_MOUSE GLYE----------------------------------GDWVWLKKFPGEHH---MAIRP GUC2D_HUMAN GUC2D_HUMAN GVYE----------------------------------GDRVWLKKFPGDQH---IAIRP GUC2D_BOVIN GUC2D_BOVIN GLYE----------------------------------GDWVWLKKFPGDRH---IAIRP GUC2D_CANFA GUC2D_CANFA GLFE----------------------------------GDWVWLKKFPGDQH---IAIRP GUC2F_BOVIN GUC2F_BOVIN AIYE----------------------------------GDWVWLKKFPSGNFGDIKSVES GUC2F_HUMAN GUC2F_HUMAN AIYE----------------------------------GDWVWLKKFSLGDFGDLKSIKS GUC2F_MOUSE GUC2F_MOUSE AIYE----------------------------------GDWVWLKKFPPGDFGDIKSIKS GUC2F_RAT GUC2F_RAT AIYQ----------------------------------GDWVWLKKFPPGDFGDIKSIKS Q9PUK0_RANPI Q9PUK0_RANPI AVYE----------------------------------GDWVWLKKFEPGPY---HELRQ B3DHF2_DANRE B3DHF2_DANRE AVYE----------------------------------GDWVWLKKFTEGHF---KEVKQ Q4SY29_TETNG Q4SY29_TETNG AVYE----------------------------------GDWVWLKKFQEGHF---KEVKQ P87342_ORYLA P87342_ORYLA AVYE----------------------------------GDWVWLKKFEEGQF---KEVKQ Q9W614_ORYLA Q9W614_ORYLA AVYE----------------------------------GDWVWLKKFEEGQF---KEVKQ MATCH : : *: .***: : CONSENSUS ???E??????????????????????????????????GDWVWLKK??????????????

GUC2D_RAT GUC2D_RAT SSLSLLRKMREMRHENVTAFLGLFVGP----------EVSA-MVLEHCARGSLEDLLRNE Q4TAT8_TETNG Q4TAT8_TETNG NTKNLFSQLREMRHENLNLYLGLFLDS----------GIFA-LVEEHCPRGSLADLLSDP P79999_ORYLA P79999_ORYLA NTQNLFSQLREMRHENLNLYLGLFVDS----------GILALVVPEHCPRGSLADLLADS Q7T2Q2_ORYLA Q7T2Q2_ORYLA NTQNLFSQLREMRHENLNLYLGLFVDS----------GILA-LVVEHCPRGSLADLLADS A2BFQ0_DANRE A2BFQ0_DANRE STQTIFVKLRDMRHENLNLFLGLFMDT----------GIFG-IVTEHCTRGSLEDLLNNE Q4S8Y6_TETNG Q4S8Y6_TETNG STENVFVMLRDMRHENINLFLGLFFDF----------GIFG-VVTEHCSRGSLEDLLNNE P87343_ORYLA P87343_ORYLA STEMLFVKLRDMRHENLNLYLGLFFDS----------GIFG-IVTEHCIRGSLEDLLANE Q9W616_ORYLA Q9W616_ORYLA STEMLFVKLRDMRHENLNLYLGLFFDS----------GIFG-IVTEHCIRGSLEDLLANE Q4T7P7_TETNG Q4T7P7_TETNG KTSNVFELMKDMRHENVNPFLGFFHDC----------GLFA-IVTEFCSRGSLEDLLQND Q7T3I2_ORYLA Q7T3I2_ORYLA KTSDVFELMKDMRHENINPFLGFFHDC----------GVFA-IVTEFCSRGSLEDLLLND Q9W615_ORYLA Q9W615_ORYLA KTSDVFELMKDMRHENINPFLGFFHDC----------GVFA-IVTEFCSRGSLEDLLLND O57480_CHICK O57480_CHICK ATKLAFCKLRDLRHENVNLFLGFFHDC----------GIFA-IVSEHCSRGSLEDLLRNQ GUC2E_RAT GUC2E_RAT ATKMAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILA-VVSEHCARGSLHDLLAQR Q8C8X5_MOUSE Q8C8X5_MOUSE ATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILA-VVSEHCARGSLHDLLAQR B1ASX7_MOUSE B1ASX7_MOUSE ATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILA-VVSEHCARGSLHDLLAQR GUC2E_MOUSE GUC2E_MOUSE ATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILA-VVSEHCARGSLHDLLAQR GUC2D_HUMAN GUC2D_HUMAN ATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLA-VVSEHCTRGSLQDLLAQR GUC2D_BOVIN GUC2D_BOVIN ATKMAFSKIRELRHENVALYLGLFLAGGAGGPAAPGEGVLA-VVSEHCARGSLQDLLAQR GUC2D_CANFA GUC2D_CANFA ATKTAFSKLRELRHENVVLYLGLFLGSGGAGGSAAGEGVLA-VVSEHCARGSLHDLLAQR GUC2F_BOVIN GUC2F_BOVIN SASDIFEMMKDLRHENINPLVGFFYDS----------GVFA-IVTEFCSRRSLEDILMNQ GUC2F_HUMAN GUC2F_HUMAN RASDVFEMMKDLRHENINPLLGFFYDS----------GMFA-IVTEFCSRGSLEDILTNQ GUC2F_MOUSE GUC2F_MOUSE SASDVFEMMKDLRHENVNPLLGFFYDS----------GMFA-IVSEFCSRRSLEDILTND GUC2F_RAT GUC2F_RAT SASDVFEMMKDLRHENVNPLLGFFYDS----------GMFA-IVSEFCSRRSLEDILTQD Q9PUK0_RANPI Q9PUK0_RANPI STTSTLRKMKDLRNENVNPFLGFFSDC----------GIFA-IVTEHCSRGSLEDLLRND B3DHF2_DANRE B3DHF2_DANRE STTKIFTKMKDLRNENVNPFLGFFTDC----------EMFA-IVTEHCSRGSLHDLLRND Q4SY29_TETNG Q4SY29_TETNG STTKILTKMKDLRNENVNPFLGFFSDC----------SMFA-VVTEHCSRGSLQDLLRNE P87342_ORYLA P87342_ORYLA STTKIFTKMKDLRNENVNPFLGFFLDC----------SMFA-VVTEHCSRGSLQDLLRNE Q9W614_ORYLA Q9W614_ORYLA STTKIFTKMKDLRNENVNPFLGFFLDC----------SMFA-VVTEHCSRGSLQDLLRNE MATCH : : ::::*:**: :*:* . :* *.* * ** *:* : CONSENSUS ?T???F??????RHEN????LG?F?????????????G??A??V?E?C?RGSL?DLL???

GUC2D_RAT GUC2D_RAT DLRLDWTFKASLLLDLIR--------------------GLRYLHHRHFPHGRLKSRN-CV Q4TAT8_TETNG Q4TAT8_TETNG NMRLDWMFKSSLLMDLIKVSGGHRGVGVQQCLTPSGFQGMKYLHLRGLCHGRLKSTN-CL P79999_ORYLA P79999_ORYLA DVRLDWMFKSSLLMDLIK--------------------GMKYLHLRGLTHGRLKSTN-CL Q7T2Q2_ORYLA Q7T2Q2_ORYLA DVRLDWMFKSSLLMDLIK--------------------GMKYLHLRGLTHGRLKSTN-CL A2BFQ0_DANRE A2BFQ0_DANRE EMRLDWMFKSSLLLDLIR--------------------GMKYLHNRGIIHGRLKSRN-CV Q4S8Y6_TETNG Q4S8Y6_TETNG NVRLDWMFKSSLLMDLIR--------------------GMKYLHNRDIIHGRLKSRN-CV P87343_ORYLA P87343_ORYLA DVRLDWMFKSSLLMDLIR--------------------GMKYLRHRNIIHGRLKSRN-CV Q9W616_ORYLA Q9W616_ORYLA DVRLDWMFKSSLLMDLIR--------------------GMKYLHHRNIIHGRLKSRN-CV Q4T7P7_TETNG Q4T7P7_TETNG DVKLDWMFKSSLLLDLIK--------------------GMKYLHHRGVSHSRLKSRN-CV Q7T3I2_ORYLA Q7T3I2_ORYLA DVKLDWMFKSSLLLDLIK--------------------GMKYLHHRGVCHTRLKSRN-CV Q9W615_ORYLA Q9W615_ORYLA DVKLDWMFKSSLLLDLIK--------------------GMKYLHHRGVCHTRLKSRN-CV O57480_CHICK O57480_CHICK DMKLDWMFKSSLLIDLIK--------------------GMRYLHHRDVVHGRRKSRN-CV GUC2E_RAT GUC2E_RAT DIKLDWMFKSSLLLDLIK--------------------GMRYLHHRGVAHGRLKSRN-CV Q8C8X5_MOUSE Q8C8X5_MOUSE EIKLDWMFKSSLLLDLIK--------------------GMRYLHHRGVAHGRLKSRN-CV B1ASX7_MOUSE B1ASX7_MOUSE EIKLDWMFKSSLLLDLIK--------------------GMRYLHHRGVAHGRLKSRN-CV GUC2E_MOUSE GUC2E_MOUSE EIKLDWMFKSSLLLDLIK--------------------GMRYLHHRGVAHGRLKSRN-CV GUC2D_HUMAN GUC2D_HUMAN EIKLDWMFKSSLLLDLIK--------------------GIRYLHHRGVAHGRLKSRN-CI GUC2D_BOVIN GUC2D_BOVIN DIKLDWMFKSSLLLDLIK--------------------GIRYLHHRGVAHGRLKSRN-CV GUC2D_CANFA GUC2D_CANFA DIKLDWMFKSSLLLDLIK--------------------GMRYLHHRGVAHGRLKSRN-CV GUC2F_BOVIN GUC2F_BOVIN DVKLDWMFKSSLLLDLIK--------------------GMKYLHHREFAHGRLKSRN-CV GUC2F_HUMAN GUC2F_HUMAN DVKLDWMFKSSLLLDLIK--------------------GMKYLHHREFVHGRLKSRN-CV GUC2F_MOUSE GUC2F_MOUSE DVKLDWMFKSSLLLDLIK--------------------GMKYLHHREFIHGRLKSRN-CV GUC2F_RAT GUC2F_RAT DVKLDWMFKSSLLLDLIK--------------------GMKYLHHREFIHGRLKSRN-CV Q9PUK0_RANPI Q9PUK0_RANPI DVKLDWMFKSSLLLDLIK--------------------GMRYLHHRDFQHGRLKSRNDCV B3DHF2_DANRE B3DHF2_DANRE DVKLDWMFKSSLVLDLIK--------------------GMKYLHHREFPHGRLKSRN-CV Q4SY29_TETNG Q4SY29_TETNG DVKLDWMFKSSLLLDLIK--------------------GMKYLHHRDFAHGRLKSRN-CV P87342_ORYLA P87342_ORYLA DVKLDWMFKSSLLLDLIK--------------------GMKYLHHREFPHGRLKSRN-CV Q9W614_ORYLA Q9W614_ORYLA DVKLDWMFKSSLLLDLIK--------------------GMKYLHHREFPHGRLKSRN-CV MATCH :::*** **:**::***: *::**: * . * * ** * *: CONSENSUS ???LDWMFKSSLL?DLIK????????????????????GM?YLHHR???HGRLKSRN?CV

GUC2D_RAT GUC2D_RAT VDTRFVLKITDHGYAEFLESHCSFRPQPAP----------------------EELLWTAP Q4TAT8_TETNG Q4TAT8_TETNG VDGRFVLKVTDYGLPMILHSQNLQVPEDEQGSQQADVKPVAFPGRLSDRACLPELLWVAP P79999_ORYLA P79999_ORYLA VDGRFVLKITDYGLPMILQSQNLSLPEDP-----------------------QDLLWTFP Q7T2Q2_ORYLA Q7T2Q2_ORYLA VDGRFVLKITDYGLPMILQSQNLSLPEDP-----------------------QDLLWTSP A2BFQ0_DANRE A2BFQ0_DANRE VDGRFVLKVTDYGFNEILNCQNIILEDNAP----------------------EDQFWTAP Q4S8Y6_TETNG Q4S8Y6_TETNG VDGRFVLKVTDYGFNEILIAQGVNTDEEKP----------------------EDLLWTAP P87343_ORYLA P87343_ORYLA VDGRFVLKVTDYGFNEIMNTQEVDVEEEKA----------------------EDLLWTAP Q9W616_ORYLA Q9W616_ORYLA VDGRFVLKVTDYGFNEIMNTQEVDVEEEKA----------------------EDLLWTAP Q4T7P7_TETNG Q4T7P7_TETNG VDGRFVLKITDYGFNEVLDAQRFPYTEPPE----------------------DELLWTAP Q7T3I2_ORYLA Q7T3I2_ORYLA VDGRFVLKVTDYGYNEVLESQRFPYAEERP----------------------EELLWTAP Q9W615_ORYLA Q9W615_ORYLA VDGRFVLKVTDYGYNEVLESQRFPYAEERP----------------------EELLWTAP O57480_CHICK O57480_CHICK VDGRFVLKVTDHGYNELLEAQRVPTPTPQP----------------------QERLWTAP GUC2E_RAT GUC2E_RAT VDGRFVLKVTDHGHGRLLEAQRVLPEPPSA----------------------EDQLWTAP Q8C8X5_MOUSE Q8C8X5_MOUSE VDGRFVLKVTDHGHGRLLEAQRVLPEPPSA----------------------EDQLWTAP B1ASX7_MOUSE B1ASX7_MOUSE VDGRFVLKVTDHGHGRLLEAQRVLPEPPSA----------------------EDQLWTAP GUC2E_MOUSE GUC2E_MOUSE VDGRFVLKVTDHGHGRLLEAQRVLPEPPSA----------------------EDQLWTAP GUC2D_HUMAN GUC2D_HUMAN VDGRFVLKITDHGHGRLLEAQKVLPEPPRA----------------------EDQLWTAP GUC2D_BOVIN GUC2D_BOVIN VDGRFVLKVTDHGHGRLLEAQRVLPEPPSA----------------------EDQLWTAP GUC2D_CANFA GUC2D_CANFA VDGRFVLKVTDHGHARLMEAQRVLLEPPSA----------------------EDQLWTAP GUC2F_BOVIN GUC2F_BOVIN VDGRFVLKVTDYGFNDILETLRLSQEEPSA----------------------EELLWTAP GUC2F_HUMAN GUC2F_HUMAN VDGRFVLKVTDYGFNDILEMLRLSEEESSM----------------------EELLWTAP GUC2F_MOUSE GUC2F_MOUSE VDGRFVLKVTDYGFNDILEMLRLSEEEPSE----------------------EELLWTAP GUC2F_RAT GUC2F_RAT VDGRFVLKVTDYGFNNILEMLRLSEEEPSE----------------------EELLWTAP Q9PUK0_RANPI Q9PUK0_RANPI VDGRFVLKITDYGYNEIVEHQKAPRQTSRP----------------------GELFWTAP B3DHF2_DANRE B3DHF2_DANRE VDGRFVLKITDYGYNEILETQKAPKETLPP----------------------EDLFWTAP Q4SY29_TETNG Q4SY29_TETNG VDGRFVLKITDYGFNELLECQKAPLEEPPP----------------------EELFWTAP P87342_ORYLA P87342_ORYLA VDGRFVLKITDYGFNELLESQKAPVEEPPP----------------------EELYWTAP Q9W614_ORYLA Q9W614_ORYLA VDGRFVLKITDYGFNELLESQKAPVEEPPP----------------------EELYWTAP MATCH ** *****:**:* .: : *. * CONSENSUS VDGRFVLK?TD?G????L??Q???????????????????????????????????WTAP

GUC2D_RAT GUC2D_RAT ELLRGPRGPWGPGKATFKGDVFSLGIILQEVLTRDPPYCSWGLSAE----EIIRKVASPP Q4TAT8_TETNG Q4TAT8_TETNG ELLRNPV--QG-G--SFAGDVFSFSIIIQEVITRSLPYAMMDMPAH----EIVERLKKPP P79999_ORYLA P79999_ORYLA ELLRNPV--RE-G--SFAGDVFSFSIIIQEVISRTLPYAMMDMPAH----EIVDRLMKPP Q7T2Q2_ORYLA Q7T2Q2_ORYLA ELLRNPV--RG-G--SFAGDVFSFSIIIQEVISRTLPYAMMDMPAH----EIVDRLMKPP A2BFQ0_DANRE A2BFQ0_DANRE EILRNPDLKKK-G--TYPGDVYSFSIIMQEVISRCAPFCMLDMPPE----EIIEKVRSPP Q4S8Y6_TETNG Q4S8Y6_TETNG ELLRNSSLRRK-G--TFTGDIYSFSIVTQEVVCRSAPFCMLDMPAK----EIISKVKVPP P87343_ORYLA P87343_ORYLA ELLRNLNLRRK-G--SFPGDVYSFAIIMQEVVSRSAPFCMLDMPPK----EIISKVKESP Q9W616_ORYLA Q9W616_ORYLA ELLRNLNLRRK-G--SFPGDVYSFAIIMQEVVSRSAPFCMLDMPPK----EIISKVKESP Q4T7P7_TETNG Q4T7P7_TETNG EILRMPGQPGVYG--TLPGDVYSFAIIMQEVVIRGPPFCTLNLIQCFYVLEILEKLRKPP Q7T3I2_ORYLA Q7T3I2_ORYLA EVLRSGQAGLH-G--TLPADVYSFAIIMQEVVIRGPPFCMLDLSDA----EIIEKVRRPP Q9W615_ORYLA Q9W615_ORYLA EVLRSGQAGLH-G--TLPADVYSFAIIMQEVVIRGPPFCMLDLSDA----EIIEKVRRPP O57480_CHICK O57480_CHICK ELLRDAALERR-G--SFRGDVYGIGIIMQEVICRSAPYCMLGLPPE----EIIEKVARPP GUC2E_RAT GUC2E_RAT ELLRDPALERR-G--TLAGDVFSLGIIMQEVVCRSTPYAMLELTPE----EVIQRVRSPP Q8C8X5_MOUSE Q8C8X5_MOUSE ELLRDPSLERR-G--TLAGDVFSLAIIMQEVVCRSTPYAMLELTPE----GKV------- B1ASX7_MOUSE B1ASX7_MOUSE ELLRDPSLERR-G--TLAGDVFSLAIIMQEVVCRSTPYAMLELTPE----EVIQRVRSPP GUC2E_MOUSE GUC2E_MOUSE ELLRDPSLERR-G--TLAGDVFSLAIIMQEVVCRSTPYAMLELTPE----EVIQRVRSPP GUC2D_HUMAN GUC2D_HUMAN ELLRDPALERR-G--TLAGDVFSLAIIMQEVVCRSAPYAMLELTPE----EVVQRVRSPP GUC2D_BOVIN GUC2D_BOVIN ELLRDPVLERR-G--TLAGDVFSLGIIMQEVVCRSAPYAMLELTPE----EVVKRVQSPP GUC2D_CANFA GUC2D_CANFA ELLRDPALERR-G--TLPGDVFSLGIIMQEVVCRSAPYAMLELTPE----EVVERVRSPP GUC2F_BOVIN GUC2F_BOVIN ELLRAPRGSRL-R--SFAGDVYSFAIIMQEVMVRGTPFCMMDLPAK----EIIERIKKPP GUC2F_HUMAN GUC2F_HUMAN ELLRAPRGSRL-G--SFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQ----EIINRLKKPP GUC2F_MOUSE GUC2F_MOUSE ELLRAPGGIRL-G--SFAGDVYSFAIIMQEVMVRGAPFCMMDLPAK----EIIDRLKMPP GUC2F_RAT GUC2F_RAT ELLRAPGGIRL-G--SFAGDVYSFAIIMQEVMVRGAPFCMMDLSAK----EVIDRLKMPP Q9PUK0_RANPI Q9PUK0_RANPI ELLRDQNLARR-G--TFKGDVFSFAIILQEVVVRGPPYCMSGLSAE----EIIRKVKKPP B3DHF2_DANRE B3DHF2_DANRE EHLRDPESPRK-G--TYKGDVYSFAIILQEVVVRGAPYCMLGLSPE----EIIRKVKKPP Q4SY29_TETNG Q4SY29_TETNG EFLRDITSTRK-G--TSKGDVYSFSIILQEVVVRGPPYCMLGLPAN----EIIRKVKKPP P87342_ORYLA P87342_ORYLA ELLRDLTLFHK-G--TYKGDVYSFSIILQEVVVRGPPYCMLGLPPE----EIIRKVKKPP Q9W614_ORYLA Q9W614_ORYLA ELLRDLTHFHK-G--TYKGDVYSFSIILQEVVVRGPPYCMLGLPPE----EIIRKVKKPP MATCH * ** : .*::.:.*: ***: * *:. : : CONSENSUS E?LR????????G?????GDV?S??II?QEV??R??P??M??????????E???????PP

GUC2D_RAT GUC2D_RAT PLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRML Q4TAT8_TETNG Q4TAT8_TETNG PLCRPLVSVDEAPTECLSLMNECWNEEPSKRPGFNDIFKQFRGINKGKKANIIDSMLRML P79999_ORYLA P79999_ORYLA PLCRPVVSVDEAPAECLNLMNECWNEDPTKRPTFDDIFKQFRGISRGRRANIIDSMLRML Q7T2Q2_ORYLA Q7T2Q2_ORYLA PLCRPVVSVDEAPAECLNLMNECWNEDPTKRPTFDDIFKQFRGISRGRRANIIDSMLRML A2BFQ0_DANRE A2BFQ0_DANRE PLCRPTVSMDEAPLDVIQLMKQAWSEEPEQRPTFEDIFRQFKSMNKGKKTNIIDSMLRML Q4S8Y6_TETNG Q4S8Y6_TETNG PLCRPELSVDEAPLDVIQIVKQAWSEEPERRPTFEEIFKQFKSISRGKKTNIIDSMLRML P87343_ORYLA P87343_ORYLA PLCRPVVSVEEAPLDIIQLMKQAWSEEPDKRPTFEEIFKQFKGNSKAKKTNIIDSMLRML Q9W616_ORYLA Q9W616_ORYLA PLCRPVVSVEEAPLDIIQLMKQAWSEEPDKRPTFEEIFKQFKGNSKAKKTNIIDSMLRML Q4T7P7_TETNG Q4T7P7_TETNG PLCRPVVSPDYAPLECIQLMKQCWSEQPDKRPAFDEIFDQFKNINKGKKTNIIDSMLRML Q7T3I2_ORYLA Q7T3I2_ORYLA PLCRPVVSPDYAPMECIQLMKQCWTETPDKRPTFDDIFDQFKNINKGRKTNIIDSMLRML Q9W615_ORYLA Q9W615_ORYLA PLCRPVVSPDYAPMECIQLMKQCWTETPDKRPTFDDIFDQFKNINKGRKTNIIDSMLRML O57480_CHICK O57480_CHICK PLCRPAVSADQAPLECIHLMKQCWSEQPERRPNIDQIFDQFKGINKGRKTNIIDSMLRML GUC2E_RAT GUC2E_RAT PLCRPLVSMDQAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRML Q8C8X5_MOUSE Q8C8X5_MOUSE ----------------------VWGQ---------------------------------- B1ASX7_MOUSE B1ASX7_MOUSE PLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKTNIIDSMLRML GUC2E_MOUSE GUC2E_MOUSE PLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKTNIIDSMLRML GUC2D_HUMAN GUC2D_HUMAN PLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRML GUC2D_BOVIN GUC2D_BOVIN PLCRPSVSIDQAPMECIQLMKQCWAEQPELRPSMDRTFELFKSINKGRKMNIIDSMLRML GUC2D_CANFA GUC2D_CANFA PLCRPSVSMDQAPVECIQLMKQCWAEHPDLRPSLGHIFDQFKSINKGRKTNIIDSMLRML GUC2F_BOVIN GUC2F_BOVIN PVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRML GUC2F_HUMAN GUC2F_HUMAN PVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRML GUC2F_MOUSE GUC2F_MOUSE PVYRPVVSPEYAPAECLQLMKQCWAEASEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRML GUC2F_RAT GUC2F_RAT PVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRML Q9PUK0_RANPI Q9PUK0_RANPI PLCRPTVGPDQAPWECIQLMKQCWSELPERRPTFDEIFDQFKTINKGKKTNIIDSMLRML B3DHF2_DANRE B3DHF2_DANRE PMCRPTVAPDQAPLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTNIIDSMLRML Q4SY29_TETNG Q4SY29_TETNG PMCRPTVAPDQAPLECIQLMKQCWSELPERRPTFDEIFDRFKLINKGKKTNIIDSMLRML P87342_ORYLA P87342_ORYLA PMCRPTVAPDQAPLECIQLMKQCWSEQPDRRPTFEEIFDRFKIINKGKKTNIIDSMLRML Q9W614_ORYLA Q9W614_ORYLA PMCRPTVAPDQAPLECIQLMKQCWSEQPDRRPTFEEIFDRFKIINKGKKTNIIDSMLRML MATCH * : CONSENSUS P?CRP?V????AP?EC??LM?QCW?E?P??RP?????F??FK???KG?KTNIIDSMLRML

GUC2D_RAT GUC2D_RAT EKYSQSLEGLVQERTEELELERRKTERLLSQMLPP-----------------------SV Q4TAT8_TETNG Q4TAT8_TETNG EQYSSNLEDLIRERTDELEVERTKTDKLVGQLLPK-----------------------SV P79999_ORYLA P79999_ORYLA EQYSSNLEDLIRERTDELEVERNKTEKLVGQLLPK-----------------------SV Q7T2Q2_ORYLA Q7T2Q2_ORYLA EQYSSNLEDLIRERTDELEVERNKTEKLVGQLLPK-----------------------SV A2BFQ0_DANRE A2BFQ0_DANRE EQYSSNLEDLIRERTEELEVERQKTDALLAQMLPK-----------------------SV Q4S8Y6_TETNG Q4S8Y6_TETNG EQYSTNLEDLIRERTEELEVERQKTDKLVAAMLPK-----------------------SV P87343_ORYLA P87343_ORYLA EQYSSNLEDLIRERTEELEVERQKTDNLVAQMLPK-----------------------SV Q9W616_ORYLA Q9W616_ORYLA EQYSSNLEDLIRERTEELEVERQKTDNLVAQMLPK-----------------------SV Q4T7P7_TETNG Q4T7P7_TETNG EQYSSNLEELIRERTEELEIEKQKTEKLLTQMLPPCVNADEPNQSVHLHGSASSSPFRSV Q7T3I2_ORYLA Q7T3I2_ORYLA EQYSSNLEELIRERTEELEIEKQKTEKLLTQMLPP-----------------------SV Q9W615_ORYLA Q9W615_ORYLA EQYSSNLEELIRERTEELEIEKQKTEKLLTQMLPP-----------------------SV O57480_CHICK O57480_CHICK EQYSSNLEDLIRERTEELEIEKQKTDKLLTQMLPP-----------------------SV GUC2E_RAT GUC2E_RAT EQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPP-----------------------SV Q8C8X5_MOUSE Q8C8X5_MOUSE ------------------------------------------------------------ B1ASX7_MOUSE B1ASX7_MOUSE EQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPP-----------------------SV GUC2E_MOUSE GUC2E_MOUSE EQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPP-----------------------SV GUC2D_HUMAN GUC2D_HUMAN EQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPP-----------------------SV GUC2D_BOVIN GUC2D_BOVIN EQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPP-----------------------SV GUC2D_CANFA GUC2D_CANFA EQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPP-----------------------SV GUC2F_BOVIN GUC2F_BOVIN EQYSSNLEDLIQERTEELEIEKQKTEKLLTQMLPP-----------------------SV GUC2F_HUMAN GUC2F_HUMAN EQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPP-----------------------SV GUC2F_MOUSE GUC2F_MOUSE EQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPL-----------------------SV GUC2F_RAT GUC2F_RAT EQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPP-----------------------SV Q9PUK0_RANPI Q9PUK0_RANPI EQYSSNLEDLIRERTEELEVEKQKTEKLSFQMLPP-----------------------SV B3DHF2_DANRE B3DHF2_DANRE EQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPP-----------------------SV Q4SY29_TETNG Q4SY29_TETNG EQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPP-----------------------SV P87342_ORYLA P87342_ORYLA EQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPP-----------------------SV Q9W614_ORYLA Q9W614_ORYLA EQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPP-----------------------SV MATCH CONSENSUS EQYSSNLEDLIRERTEELE?E?QKT??L???MLP????????????????????????SV

GUC2D_RAT GUC2D_RAT AHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDV Q4TAT8_TETNG Q4TAT8_TETNG AQALKKGRPVQPEHYSESTLYFSDIVGFTTISALSEPIEVVDLLNDLYTMFDAIIATHDV P79999_ORYLA P79999_ORYLA AQALKKGKPVQPEHYSDCTLYFSDIVGFTTISALSEPIEVVDLLNDLYTMFDAIIASHDV Q7T2Q2_ORYLA Q7T2Q2_ORYLA AQALKKGKPVQPEHYSDCTLYFSDIVGFTTISALSEPIEVVDLLNDLYTMFDAIIASHDV A2BFQ0_DANRE A2BFQ0_DANRE ALALKTGKPVKPEHFAEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDV Q4S8Y6_TETNG Q4S8Y6_TETNG AKALKTGKPVIPEHFSEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDAIIGLHDV P87343_ORYLA P87343_ORYLA AQSLKLGKPVEPEHFSEVTLYFSDIVGFSTISTLSEPIEVVDLLNDLYSLFDAIIPLHDV Q9W616_ORYLA Q9W616_ORYLA AQSLKLGKPVEPEHFSEVTLYFSDIVGFSTISTLSEPIEVVDLLNDLYSLFDAIIPLHDV Q4T7P7_TETNG Q4T7P7_TETNG AEALKVGGIVEPEHFGSVTIYFSDIVGFTTISANSEPIEVVDLLNNLYTIFDAIIGNHDV Q7T3I2_ORYLA Q7T3I2_ORYLA AEALMVGGTVKPEYFDSVSLYFSDIVGFTTISANSEPIEVVDLLNDLYTLFDAIIGNHDV Q9W615_ORYLA Q9W615_ORYLA AEALMVGGTVKPEYFDSVSLYFSDIVGFTTISANSEPIEVVDLLNDLYTLFDAIIGNHDV O57480_CHICK O57480_CHICK AEALKMGTPVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDVIIGAHDV GUC2E_RAT GUC2E_RAT AEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV Q8C8X5_MOUSE Q8C8X5_MOUSE ------------------------------------------------------------ B1ASX7_MOUSE B1ASX7_MOUSE AEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDV GUC2E_MOUSE GUC2E_MOUSE AEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDV GUC2D_HUMAN GUC2D_HUMAN AEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV GUC2D_BOVIN GUC2D_BOVIN AEALKMGTPVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV GUC2D_CANFA GUC2D_CANFA AEALKMGTPVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV GUC2F_BOVIN GUC2F_BOVIN AESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV GUC2F_HUMAN GUC2F_HUMAN AESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV GUC2F_MOUSE GUC2F_MOUSE AESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV GUC2F_RAT GUC2F_RAT AESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV Q9PUK0_RANPI Q9PUK0_RANPI AEALKTGGTVEPEYFDLVTIYFSDIVGFTTISALSEPIEVVDLLNDLYSLFDAVLGNHDV B3DHF2_DANRE B3DHF2_DANRE AEALKTGASVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDV Q4SY29_TETNG Q4SY29_TETNG AEALKTGGTVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLSSHDV P87342_ORYLA P87342_ORYLA ADTLKTGATVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYTLFDAVLSNHDV Q9W614_ORYLA Q9W614_ORYLA ADTLKTGATVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYTLFDAVLSNHDV MATCH CONSENSUS A??LK?G??V?PE?F??VT?YFSDIVGFTTIS??SEPIEVVDLLNDLY??FDA????HDV

GUC2D_RAT GUC2D_RAT YKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHS Q4TAT8_TETNG Q4TAT8_TETNG YKVETIGDAYMVASGVPNRNGNRHAAEVANMSLDILHSIAAFKIKHMPEIKVKIRIGLHS P79999_ORYLA P79999_ORYLA YKVETIGDAYMVASGVPNRNGNRHAAEVSNMSLDILHSIGAFKIKHMPEIKVKIRIGLHS Q7T2Q2_ORYLA Q7T2Q2_ORYLA YKVETIGDAYMVASGVPNRNGNRHAAEVSNMSLDILHSIGAFKIKHMPEIKVKIRIGLHS A2BFQ0_DANRE A2BFQ0_DANRE YKVETIGDAYMVASGVPNRNGTRHAAEMANMSLDILHCIGTFKMRHMPDVKVKIRIGLHS Q4S8Y6_TETNG Q4S8Y6_TETNG YKVETIGDAYMVASGVPARNGNRHAAEMANMSLDILHCIGTFKMRHMPDLKVRIRIGLHS P87343_ORYLA P87343_ORYLA YKVETIGDAYMVASGVPTRNGNRHAAEIANMSLDILHCIGTFKARHMPDLKIRIRIGLHS Q9W616_ORYLA Q9W616_ORYLA YKVETIGDAYMVASGVPTRNGNRHAAEIANMSLDILHCIGTFKARHMPDLKIRIRIGLHS Q4T7P7_TETNG Q4T7P7_TETNG YKVLRLSSFHQTTITSRYQMAASYSA-----------------------------VGGDH Q7T3I2_ORYLA Q7T3I2_ORYLA YKVETIGDAYMVASGVPVPNANRHAAEIANMSLDILSAVGTFKMRHMPDVPVRIRIGLHT Q9W615_ORYLA Q9W615_ORYLA YKVETIGDAYMVASGVPVPNANRHAAEIANMSLDILSAVGTFKMRHMPDVPVRIRIGLHT O57480_CHICK O57480_CHICK YKVETIGDAYMVASGLPKRNGNRHAGEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHS GUC2E_RAT GUC2E_RAT YKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHS Q8C8X5_MOUSE Q8C8X5_MOUSE ------------------------------------------------------------ B1ASX7_MOUSE B1ASX7_MOUSE YKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHS GUC2E_MOUSE GUC2E_MOUSE YKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHS GUC2D_HUMAN GUC2D_HUMAN YKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHS GUC2D_BOVIN GUC2D_BOVIN YKVETIGDAYMVASGLPQRNGHRHAAEIANMALDILSAVGTFRMRHMPEVPVRIRIGLHS GUC2D_CANFA GUC2D_CANFA YKVETIGDAYMVASGLPQRNGQRHAAEIANMALDILSAVGSFRMRHMPEVPVRIRIGLHS GUC2F_BOVIN GUC2F_BOVIN YKVETIGDAYMVASGLPKRNGMRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHS GUC2F_HUMAN GUC2F_HUMAN YKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHS GUC2F_MOUSE GUC2F_MOUSE YKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHS GUC2F_RAT GUC2F_RAT YKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHT Q9PUK0_RANPI Q9PUK0_RANPI YKVETIGDAYMVASGLPKRNGNRHAAAIASMSLDILSSVGTFQMRHMPDVPVRIRIGLHT B3DHF2_DANRE B3DHF2_DANRE YKVETIGDAYMVASGLPKKNGNKHAAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHS Q4SY29_TETNG Q4SY29_TETNG YKVETIGDAYMVASGLPKRNGNKHAAEIANMSLNILSSVGTFHMRHMPDVPVRIRIGIHS P87342_ORYLA P87342_ORYLA YKVETIGDAYMVASGLPKRNGNKHAAEIANMSLNILSSVGSFHMRHMPDVPVRIRIGIHS Q9W614_ORYLA Q9W614_ORYLA YKVETIGDAYMVASGLPKRNGNKHAAEIANMSLNILSSVGSFHMRHMPDVPVRIRIGIHS MATCH CONSENSUS YKVETIGDAYMVASG?P?RNG??HAAE?ANMSL?IL???G?F??RHMP???V?IRIG?H?

GUC2D_RAT GUC2D_RAT GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ Q4TAT8_TETNG Q4TAT8_TETNG GPVVAGVVGLTMPRY----CLFGDTVTTASHMEASG------------------------ P79999_ORYLA P79999_ORYLA GPVVAGVVGLTMPRY----CLFGDTVTTASLMESSG------------------------ Q7T2Q2_ORYLA Q7T2Q2_ORYLA GPVVAGVVGLTMPRY----CLFGDTVTTASLMESSG------------------------ A2BFQ0_DANRE A2BFQ0_DANRE GPVVAGVVGLKMPRY----CLFGDTVNTASRMESTG------------------------ Q4S8Y6_TETNG Q4S8Y6_TETNG GPVVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ P87343_ORYLA P87343_ORYLA GPVVAGVVGLTMPRY----CLFGDTVNTTSRMESTS------------------------ Q9W616_ORYLA Q9W616_ORYLA GPVVAGVVGLTMPRY----CLFGDTVNTTSRMESTS------------------------ Q4T7P7_TETNG Q4T7P7_TETNG RRCLHGGVGSSCSQWQPPRC--GNSQHVPRHSERCR------------------------ Q7T3I2_ORYLA Q7T3I2_ORYLA GPCVAGVVGLTMPRY----CLFGDTVTTASRMESSG------------------------ Q9W615_ORYLA Q9W615_ORYLA GPCVAGVVGLTMPRY----CLFGDTVTTASRMESSG------------------------ O57480_CHICK O57480_CHICK GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2E_RAT GUC2E_RAT GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ Q8C8X5_MOUSE Q8C8X5_MOUSE ------------------------------------------------------------ B1ASX7_MOUSE B1ASX7_MOUSE GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2E_MOUSE GUC2E_MOUSE GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2D_HUMAN GUC2D_HUMAN GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2D_BOVIN GUC2D_BOVIN GPCVAGVVGLTMPRY----CLFGDTVNTASAMESTG------------------------ GUC2D_CANFA GUC2D_CANFA GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2F_BOVIN GUC2F_BOVIN GPVVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2F_HUMAN GUC2F_HUMAN GPVVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2F_MOUSE GUC2F_MOUSE GPVVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ GUC2F_RAT GUC2F_RAT GPVVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ Q9PUK0_RANPI Q9PUK0_RANPI GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ B3DHF2_DANRE B3DHF2_DANRE GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ Q4SY29_TETNG Q4SY29_TETNG GACVAGVVGLTMPRY----CLFGDTVNTASRMESTGLRRFSSNFSTTVPCCSQFCCVFPT P87342_ORYLA P87342_ORYLA GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ Q9W614_ORYLA Q9W614_ORYLA GPCVAGVVGLTMPRY----CLFGDTVNTASRMESTG------------------------ MATCH CONSENSUS GP?VAGVVGLTMPRY????CLFGDTV?TAS?MES?G????????????????????????

GUC2D_RAT GUC2D_RAT ----LPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETY---WLTGKTGFCRSL Q4TAT8_TETNG Q4TAT8_TETNG ----LPYRIHISLSTVKVLTSLKLGYHMETR---KAQVKGAVDTY---WLVGRDGFDKPL P79999_ORYLA P79999_ORYLA ----LPYRIHISLSTVKVLTSLKVGYHIETR---KAQVKGTEDTY---WLMGRDGFNKPL Q7T2Q2_ORYLA Q7T2Q2_ORYLA ----LPYRIHISLSTVKVLTSLKVGYHIETR---KAQVKGTEDTY---WLMGRDGFNKPL A2BFQ0_DANRE A2BFQ0_DANRE ----LPYRIHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVEETF---WLVGRDGFDKPL Q4S8Y6_TETNG Q4S8Y6_TETNG ----L---------RECLLLNLKLGYKIQVRGLTELKGKGIENTY---WLVGREDFNKHL P87343_ORYLA P87343_ORYLA ----SPYRVHVNQSTVNLLNSLKLGYKIDVRGLTELKGKGIETTY---WLVGKDDFKKSL Q9W616_ORYLA Q9W616_ORYLA ----SPYRVHVNQSTVNLLNSLKLGYKIDVRGLTELKGKGIETTY---WLVGKDDFKKSL Q4T7P7_TETNG Q4T7P7_TETNG ---NLQNEAHARCSC-------EDTYRVTHRSLCRRRGRADNASLLSVWRHGKHRLSHGV Q7T3I2_ORYLA Q7T3I2_ORYLA ----MPYRIHVHESIVKVLKELNLGYKLELRGRTEVKGKGTEETY---WLVGRVGFTKPL Q9W615_ORYLA Q9W615_ORYLA ----MPYRIHVHESIVKVLKELNLGYKLELRGRTEVKGKGTEETY---WLVGRVGFTKPL O57480_CHICK O57480_CHICK ----LPYRIHVNARTVAILRALQEGFKLDIRGKTELKGKGVEDTY---WLVGREGFTKPI GUC2E_RAT GUC2E_RAT ----LPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGVEDTY---WLVGRVGFNKPI Q8C8X5_MOUSE Q8C8X5_MOUSE --------------------------------------------------IGTL------ B1ASX7_MOUSE B1ASX7_MOUSE ----LPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTY---WLVGRLGFNKPI GUC2E_MOUSE GUC2E_MOUSE ----LPYRIHVNMSTVRILRSLDQGFQMECRGRTELKGKGIEDTY---WLVGRLGFNKPI GUC2D_HUMAN GUC2D_HUMAN ----LPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTF---WLVGRRGFNKPI GUC2D_BOVIN GUC2D_BOVIN ----LPYRIHVNRSTVQILSALNEGFLTEVRGRTELKGKGAEETY---WLVGRRGFNKPI GUC2D_CANFA GUC2D_CANFA ----LPYRIHVNMSTVRILHALDEGFQTEVRGRTELKGKGAEDTY---WLVGRRGFNKPI GUC2F_BOVIN GUC2F_BOVIN ----LPYRIHVSHSTVTILRTLGEGYEVELRGRTELKGKGTEETF---WLVGKKGFTKPL GUC2F_HUMAN GUC2F_HUMAN ----LPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETF---WLIGKKGFMKPL GUC2F_MOUSE GUC2F_MOUSE ----LPYRIHVSLSTVTILQTLSEGYEVELRGRTELKGKGTEETF---WLVGKKGFTKPL GUC2F_RAT GUC2F_RAT ----LPYRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETF---WLVGKKGFTKPL Q9PUK0_RANPI Q9PUK0_RANPI ----LPYRIHVNQSTVATLRTLPENYKIELRGKTELKGKGIEETF---WLVGKDGFNKPL B3DHF2_DANRE B3DHF2_DANRE ----LPYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIEETY---WLVGKANFTKPL Q4SY29_TETNG Q4SY29_TETNG CSSLLAYRIHVNMSTVNILHSLNEGYKIQVRGKTELKGKGIEETY---WLVGKTDFAKPL P87342_ORYLA P87342_ORYLA ----LPYRIHVNMSTVKILRSLNDGYKIDVRGKTELKGKGIEETY---WLVGKTNFSKPL Q9W614_ORYLA Q9W614_ORYLA ----LPYRIHVNMSTVKILRSLNDGYKIDVRGKTELKGKGIEETY---WLVGKTNFSKPL MATCH * CONSENSUS ????LPYRIH???STV??L??L??G?????RG?TE?KGKG?E?T????WL?G???F?K??

GUC2D_RAT GUC2D_RAT --PTPLSIQPGDP---W-----QDHINQEIRTGFAKLAR-VC------------------ Q4TAT8_TETNG Q4TAT8_TETNG --PVPPDLTGGAS---N-HGISLDEIPVERRQK--------------------------- P79999_ORYLA P79999_ORYLA --PVPPDLIGGAS---N-HGIALDEIPVERRQKFLDRQK-LIKK---------------- Q7T2Q2_ORYLA Q7T2Q2_ORYLA --PVPPDLIGGAS---N-HGIALDEIPVERRQKFLDRQK-LIKK---------------- A2BFQ0_DANRE A2BFQ0_DANRE --PIPPDLTPGAS---N-HGISLDEIPTDRRQKFLDRQK-RMGN---------------- Q4S8Y6_TETNG Q4S8Y6_TETNG --PVPPDI---------------------------------------------------- P87343_ORYLA P87343_ORYLA --PVPLDLQ-GGT---D-FGITIEEIPPDRRQKFLDRQK-KA------------------ Q9W616_ORYLA Q9W616_ORYLA --PVPLDLQ-GGT---D-FGITIEEIPPDRRQKFLDRQK-KA------------------ Q4T7P7_TETNG Q4T7P7_TETNG QWSAEKDLRRRTG---WSAGMDLPNLCQFPPKSSLGKWPTGCRWPR-------------- Q7T3I2_ORYLA Q7T3I2_ORYLA --PVPPELKTGMK---A-----PRDMKQVFHKAVKKISH-VRVVTQLHMPEDDANVMMTH Q9W615_ORYLA Q9W615_ORYLA --PVPPELKTGMK---A-----PRDMKQVFHKAVKKISH-VRVVTQLHMPEDDANVMMTH O57480_CHICK O57480_CHICK --PTPPDLLPGAS---N-HGISLDEIPAERRRKLEKARP-GQVLK--------------- GUC2E_RAT GUC2E_RAT --PKPPDLQPGAS---N-HGISLQEIPPERRKKLEKARP-GQFTGK-------------- Q8C8X5_MOUSE Q8C8X5_MOUSE ------------------------------------------------------------ B1ASX7_MOUSE B1ASX7_MOUSE --PKPPDLQPGAS---N-HGISLQEIPPERRKKLEKARP-GQFTGK-------------- GUC2E_MOUSE GUC2E_MOUSE --PKPPDLQPGAS---N-HGISLQEIPPERRKKLEKARP-GQFTGK-------------- GUC2D_HUMAN GUC2D_HUMAN --PKPPDLQPGSS---N-HGISLQEIPPERRRKLEKARP-GQFS---------------- GUC2D_BOVIN GUC2D_BOVIN --PKPPDLQPGAS---N-HGISLHEIPPDRRQKLEKARP-GQFSGK-------------- GUC2D_CANFA GUC2D_CANFA --PKPPDLQPGAS---N-HGISLQEIPLDRRWKLEKARP-GQFSGK-------------- GUC2F_BOVIN GUC2F_BOVIN --PVPPPVGKDGQ---VGHGLQSVEIAAFQRRKQKSSW---------------------- GUC2F_HUMAN GUC2F_HUMAN --PVPPPVDKDGQ---VGHGLQPVEIAAFQRRKAERQLV-RNKP---------------- GUC2F_MOUSE GUC2F_MOUSE --PVPPPVGKDGQ---VGHGLQPAEIAAFQRRKAERQLV-RNKP---------------- GUC2F_RAT GUC2F_RAT --PVPPPVGKDGQ---VGHGLQPAEIAAFQRRKAERQLV-RNKP---------------- Q9PUK0_RANPI Q9PUK0_RANPI --PKPPDIKPGCI---A-HGLTAEEISEFKRRKAEKLLS-KKEAEGGLAGNGNQGN---- B3DHF2_DANRE B3DHF2_DANRE --PNPPEIKPGDN---W-QDMMTEEIKSLFRKANRPVDK-HKI----------------- Q4SY29_TETNG Q4SY29_TETNG --PKPPDIKPGVN---W-QEMVTEEIKTLFRKANRQVDK-KL------------------ P87342_ORYLA P87342_ORYLA --PKPPEIKPRGQLARNGDGGNQDSFPPGQQTSAQNVLKTGREDNIPKMELLRRQRSIRM Q9W614_ORYLA Q9W614_ORYLA --PKPPEIKPGDN---W-QEMVTEEIKTLFRQANRPVHKMF------------------- MATCH CONSENSUS ??P?PP??????????????????????????????????????????????????????

GUC2D_RAT GUC2D_RAT ----------- Q4TAT8_TETNG Q4TAT8_TETNG ----------- P79999_ORYLA P79999_ORYLA ----------- Q7T2Q2_ORYLA Q7T2Q2_ORYLA ----------- A2BFQ0_DANRE A2BFQ0_DANRE ----------- Q4S8Y6_TETNG Q4S8Y6_TETNG ----------- P87343_ORYLA P87343_ORYLA ----------- Q9W616_ORYLA Q9W616_ORYLA ----------- Q4T7P7_TETNG Q4T7P7_TETNG ----------- Q7T3I2_ORYLA Q7T3I2_ORYLA H---------- Q9W615_ORYLA Q9W615_ORYLA H---------- O57480_CHICK O57480_CHICK ----------- GUC2E_RAT GUC2E_RAT ----------- Q8C8X5_MOUSE Q8C8X5_MOUSE ----------- B1ASX7_MOUSE B1ASX7_MOUSE ----------- GUC2E_MOUSE GUC2E_MOUSE ----------- GUC2D_HUMAN GUC2D_HUMAN ----------- GUC2D_BOVIN GUC2D_BOVIN ----------- GUC2D_CANFA GUC2D_CANFA ----------- GUC2F_BOVIN GUC2F_BOVIN ----------- GUC2F_HUMAN GUC2F_HUMAN ----------- GUC2F_MOUSE GUC2F_MOUSE ----------- GUC2F_RAT GUC2F_RAT ----------- Q9PUK0_RANPI Q9PUK0_RANPI ----------- B3DHF2_DANRE B3DHF2_DANRE ----------- Q4SY29_TETNG Q4SY29_TETNG ----------- P87342_ORYLA P87342_ORYLA RMDLETKRSKS Q9W614_ORYLA Q9W614_ORYLA ----------- MATCH CONSENSUS ???????????


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