Alignment of the gene Family HBG101120 of HOVERGEN

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Isoforms are ON
Q9DE05_RAJER Q9DE05_RAJER MDDL-DFETMEEVFANL---------------SDLTGGLNKTCSLNK-GFQFYYLPIMYI Q4SPQ4_TETNG Q4SPQ4_TETNG TADV-NLTSLLNLS--------------------DVHNNTRGCSLTNTGFQFYYLPTVYI Q0V9S6_XENTR Q0V9S6_XENTR MTEV-FLSALLNVTQSTLLASG------------SSAGNVTKCSLTKTGFQFYYLPAVYI Q90X57_XENLA Q90X57_XENLA MTEV-FLSALLNVTQSTLLASG------------SSAGNVTKCSLTKTGFQFYYLPAVYI P2RY1_CHICK P2RY1_CHICK MTEA-LISAALNGTQPELLAG---GW--------AAGNATTKCSLTKTGFQFYYLPTVYI P2RY1_MELGA P2RY1_MELGA MTEA-LISAALNGTQPELLAG---GW--------AAGNASTKCSLTKTGFQFYYLPTVYI Q5XX73_CANFA Q5XX73_CANFA SAEA-LWPPLPNGT-AAFPGGQGGPWGNSTASAAAAAAAPFTCALTKTGFQFYYLPAVYI B5MBX7_HUMAN B5MBX7_HUMAN -----------------------------------------------------YLPAVYI P2RY1_RAT P2RY1_RAT MTEV-PWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYI P2RY1_MOUSE P2RY1_MOUSE MTEV-PWSVVPNGTDAAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYI Q544J5_MOUSE Q544J5_MOUSE MTEV-PWSVVPNGTDAAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYI Q8BMJ5_MOUSE Q8BMJ5_MOUSE MTEV-PWSVVPNGTDAAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYI P2RY1_CAVPO P2RY1_CAVPO MTEV-LWPAAPNGTDAAFLASPGFHWGNSTATSTAAAAAPFRCALTKTGFQFYYLPAVYI P2RY1_BOVIN P2RY1_BOVIN MTEV-LWPAVPNGTDTAFLADPGSPWGNSTVTSTAAVASPFKCALTKTGFQFYYLPAVYI B2R9U4_HUMAN B2R9U4_HUMAN MTEV-LWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYI P2RY1_HUMAN P2RY1_HUMAN MTEV-LWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYI P2RY6_MOUSE P2RY6_MOUSE -------MEQDNGTIQ------------------APGLPPTTCVYRE-DFKRLLLTPVYS Q3UQ86_MOUSE Q3UQ86_MOUSE -------MEQDNGTIQ------------------APGLPPTTCVYRE-DFKRLLLTPVYS P2RY6_RAT P2RY6_RAT -------MERDNGTIQ------------------APGLPPTTCVYRE-DFKRLLLPPVYS Q5YA26_PIG Q5YA26_PIG ------------------------------------------------------------ P2RY6_HUMAN P2RY6_HUMAN -------MEWDNGTGQ------------------ALGLPPTTCVYRE-NFKQLLLPPVYS Q5R5L6_PONAB Q5R5L6_PONAB ----MEWDNGTGQ---------------------ALGLPPTTCVYRE-NFKQLLLPPVYS P2RY3_CHICK P2RY3_CHICK MSMA------------------------------NFTGGRNSCTFHE-EFKQVLLPLVYS P2RY3_MELGA P2RY3_MELGA MSMA------------------------------NFTAGRNSCTFQE-EFKQVLLPLVYS Q4SEL9_TETNG Q4SEL9_TETNG ----------------------------------------TNCTYKE-DFKRILLPAVYT Q4SEL5_TETNG Q4SEL5_TETNG ----------------------------------------LYCKFKE-DFKYILLPVSYA Q6P852_XENTR Q6P852_XENTR NASG------------------------------GGENSTYKCKFDE-DFKYVLLPVSYG P2RY2_RAT P2RY2_RAT -----MAAGLDSWNSTING-----TW--------EGDELGYKCRFNE-DFKYVLLPVSYG Q3U185_MOUSE Q3U185_MOUSE -----MAADLEPWNSTINS-----TW--------EGDELGYKCRFNE-DFKYVLLPVSYG P2RY2_MOUSE P2RY2_MOUSE -----MAADLEPWNSTING-----TW--------EGDELGYKCRFNE-DFKYVLLPVSYG Q3U217_MOUSE Q3U217_MOUSE AADLEPWNSTINGT-----------W--------EGDELGYKCRFNE-DFKYVLLPVSYG B5B287_RABIT B5B287_RABIT -----MAAGSDPWNGTANG-----TW--------EGDELGYKCRFNE-DFKYVLLPVSYG P2RY2_HUMAN P2RY2_HUMAN -----MAADLGPWNDTING-----TW--------DGDELGYRCRFNE-DFKYVLLPVSYG Q5BJ79_XENTR Q5BJ79_XENTR AGGI-MATLHPSLLTTLPLP----KN--------LTNNTEDSCVFNE-GFKFLLLPISYS A9UMP2_XENLA A9UMP2_XENLA TEDI-MATSYPTFLTTPYLPMNLLMN--------LTNDTEDICVFDE-GFKFLLLPVSYS P2RY4_XENLA P2RY4_XENLA TEDI-MATSYPTFLTTPYLPMKLLMN--------LTNDTEDICVFDE-GFKFLLLPVSYS Q7ZWQ7_XENLA Q7ZWQ7_XENLA TEDI-MATSYPTFLTTPYLPMNLLMN--------LTNDTEDICVFDE-GFKFLLLPVSYS P2RY4_MOUSE P2RY4_MOUSE ------MTSADSLLFTSLGP--------------SPSSGDGDCKFNE-EFKFILLPLSYA Q0VBT7_MOUSE Q0VBT7_MOUSE ------MTSADSLLFTSLGP--------------SPSSGDGDCKFNE-EFKFILLPLSYA P2RY4_RAT P2RY4_RAT ------MTSAESLLFTSLGP--------------SPSSGDGDCRFNE-EFKFILLPMSYA P2RY4_HUMAN P2RY4_HUMAN ------MASTESSLLRSLGLSPGP----------GSSEVELDCWFDE-DFKFILLPVSYA Q5DKX1_PIG Q5DKX1_PIG ------------------------------------------------------------ O57466_MELGA O57466_MELGA DAPV-RMFSLAPWTPTPTPWLG--GN--------TTAAAEAKCVFNE-EFKFILLPISYG Q4RP73_TETNG Q4RP73_TETNG -----------------------------------TSVINYSCRFDE-DFKYILLPVSYG Q1LY72_DANRE Q1LY72_DANRE -------------------------------MPMSSKEVNFSCTFDE-EFKYILLPVSYS MATCH CONSENSUS ??????????????????????????????????????????C??????F????LP??Y?

Q9DE05_RAJER Q9DE05_RAJER IVFVTGFIGNSVALWMFIFHMRPWSSITIYMFNLVLADLFYVFSLPILIFYYFNKTDWIF Q4SPQ4_TETNG Q4SPQ4_TETNG IVFVTGLVGNSLAIWMFVCHMRPWSSISVYMFNLALADFCYVLSLPFLIFYYFNKTDWIF Q0V9S6_XENTR Q0V9S6_XENTR VVCITGFIGNSVAIWMFIFHMKPWSSISVYMFNLALADFLYVLSLPALIFYYFNKTDWIF Q90X57_XENLA Q90X57_XENLA VVCITGFIGNSVAIWMFIFHMKPWSSISVYMFNLALADFLYVLSLPALIFYYFNKTDWIF P2RY1_CHICK P2RY1_CHICK LVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF P2RY1_MELGA P2RY1_MELGA LVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF Q5XX73_CANFA Q5XX73_CANFA LVFVTGFLGNSVAIWMFARHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWTL B5MBX7_HUMAN B5MBX7_HUMAN LVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF P2RY1_RAT P2RY1_RAT LVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF P2RY1_MOUSE P2RY1_MOUSE LVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF Q544J5_MOUSE Q544J5_MOUSE LVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF Q8BMJ5_MOUSE Q8BMJ5_MOUSE LVFIIGFLGNSVAIWMYVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF P2RY1_CAVPO P2RY1_CAVPO VVFIIGFLGNSIAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTNWIF P2RY1_BOVIN P2RY1_BOVIN LVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF B2R9U4_HUMAN B2R9U4_HUMAN LVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF P2RY1_HUMAN P2RY1_HUMAN LVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIF P2RY6_MOUSE P2RY6_MOUSE VVLVVGLPLNICVIAQICASRRTLTRSAVYTLNLALADLMYACSLPLLIYNYARGDHWPF Q3UQ86_MOUSE Q3UQ86_MOUSE VVLVVGLPLNICVIAQICASRRTLTRSAVYTLNLALADLMYACSLPLLIYNYARGDHWPF P2RY6_RAT P2RY6_RAT VVLVVGLPLNVCVIAQICASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPF Q5YA26_PIG Q5YA26_PIG ------------------------------------------------------------ P2RY6_HUMAN P2RY6_HUMAN AVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPF Q5R5L6_PONAB Q5R5L6_PONAB AVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPF P2RY3_CHICK P2RY3_CHICK VVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLAMADLLYVCSLPLLIYNYTQKDYWPF P2RY3_MELGA P2RY3_MELGA VVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPF Q4SEL9_TETNG Q4SEL9_TETNG LVLLLGLPLNAVVILKIWRTRPNLSRNNIYMLNLAIADFLYVTSLPLLIYNYGSRDYWPF Q4SEL5_TETNG Q4SEL5_TETNG LVFVFGLALNGLALYVIVFRTKAWKPSTVYMFNLTMCDTLYILTLPFLIYYYADENDWPF Q6P852_XENTR Q6P852_XENTR IVFCVGLILNILALYIFLFRIKPWNASTTYMFNLAISDMMYVISLPLLVYYYSQGDNWPF P2RY2_RAT P2RY2_RAT VVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYAQGDHWPF Q3U185_MOUSE Q3U185_MOUSE VVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPF P2RY2_MOUSE P2RY2_MOUSE VVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPF Q3U217_MOUSE Q3U217_MOUSE VVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPF B5B287_RABIT B5B287_RABIT TVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPF P2RY2_HUMAN P2RY2_HUMAN VVCVLGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPF Q5BJ79_XENTR Q5BJ79_XENTR GVFMVGLPLNITAIWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADQNNWPF A9UMP2_XENLA A9UMP2_XENLA AVFMVGLPLNIAAMWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADKNNWPF P2RY4_XENLA P2RY4_XENLA AVFMVGLPLNIAAMWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADKNNWPF Q7ZWQ7_XENLA Q7ZWQ7_XENLA AVFMVGLPLNIAAMWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADKNNWPF P2RY4_MOUSE P2RY4_MOUSE VVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPF Q0VBT7_MOUSE Q0VBT7_MOUSE VVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPF P2RY4_RAT P2RY4_RAT VVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPF P2RY4_HUMAN P2RY4_HUMAN VVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPF Q5DKX1_PIG Q5DKX1_PIG ------------------------------------------------------------ O57466_MELGA O57466_MELGA IVFVVGLPLNSWAMWIFVSRMRPWNATTTYMFNLAISDTLYVFSLPTLVYYYADRNNWPF Q4RP73_TETNG Q4RP73_TETNG LVFVFGFILNATALWLFL-KMRPWNPNTVFLFHLALSDFLYILSLPTLIYYYANHGHWPF Q1LY72_DANRE Q1LY72_DANRE LVCFFGLILNSVALWMFITKMRPWKPSTVYMFHLALSDTLYVLSLPMLIYYYANRSHWPF MATCH CONSENSUS ?V???G???N???????????????????YM??LA??D?LY???LP?L???Y?????W?F

Q9DE05_RAJER Q9DE05_RAJER GELLCKLXRFIFHVNLYGSILFLTCISVHRYTGVVHPMKSL-GRLKKKSATIVCVCVWIT Q4SPQ4_TETNG Q4SPQ4_TETNG GDVLCRLQRFIFHVNLYGSILFLTCISVHRYTAVVHPLKSL-GRLKKRSAVITSASVWLL Q0V9S6_XENTR Q0V9S6_XENTR GDALCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSL-GRLKKKNSIYISALVWFI Q90X57_XENLA Q90X57_XENLA GDALCKLQRFLFHVNLYGSILFLTCISVHRYTGVVHPLKSL-GRLKKKNSIYISALVWFI P2RY1_CHICK P2RY1_CHICK GDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSL-GRLKKKNAVYVSSLVWAL P2RY1_MELGA P2RY1_MELGA GDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSL-GRLKKKNAVYVSSLVWAL Q5XX73_CANFA Q5XX73_CANFA GDAMCKLQRFIFHANLYGSILFLTCISAHRYSGVVYPLRSL-GRLQKRTAVHVSLLVWLV B5MBX7_HUMAN B5MBX7_HUMAN GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAICISVLVWLI P2RY1_RAT P2RY1_RAT GDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAIYVSVLVWLI P2RY1_MOUSE P2RY1_MOUSE GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAIYVSVLVWLI Q544J5_MOUSE Q544J5_MOUSE GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAIYVSVLVWLI Q8BMJ5_MOUSE Q8BMJ5_MOUSE GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAIYVSVLVWLI P2RY1_CAVPO P2RY1_CAVPO GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAVYISVLVWLI P2RY1_BOVIN P2RY1_BOVIN GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAVYISVLVWLI B2R9U4_HUMAN B2R9U4_HUMAN GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRPKKKNAICISVLVWLI P2RY1_HUMAN P2RY1_HUMAN GDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL-GRLKKKNAICISVLVWLI P2RY6_MOUSE P2RY6_MOUSE GDLACRFVRFLFYANLHGSILFLTCISFQRYLGICHPLASWHKRGGRRAAWVVCGVVWLA Q3UQ86_MOUSE Q3UQ86_MOUSE GDLACRFVRFLFYANLHGSILFLTCISFQRYLGICHPLASWHKRGGRRAAWVVCGVVWLA P2RY6_RAT P2RY6_RAT GDLACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWVVCGVVWLV Q5YA26_PIG Q5YA26_PIG ------------------------CISFQRYLGICHPLAPWHKRGGRRAAWLVCGAVWLA P2RY6_HUMAN P2RY6_HUMAN GDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLA Q5R5L6_PONAB Q5R5L6_PONAB GDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLA P2RY3_CHICK P2RY3_CHICK GDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLASWHKKKGKKLTWLVCAAVWFI P2RY3_MELGA P2RY3_MELGA GDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLASWHKKKGKKLTWLVCAAVWFI Q4SEL9_TETNG Q4SEL9_TETNG GELTCKLVRFQFYSNLHGSILFLTCISVQRYVGICHPLAMWHKRGGRKMAWRVCGAVWLL Q4SEL5_TETNG Q4SEL5_TETNG SEPFCKIIRFLFYANLYGSILFLCCISLHRFIGVCYPVRSL-YWLSARRAKFISVAVWAV Q6P852_XENTR Q6P852_XENTR GVALCKIVKFLFYTNMYCSISFLLCISIHRFLGICYPMKSL-GWLKVRNARIISVVVWVI P2RY2_RAT P2RY2_RAT STVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSL-SWGHARYARRVAAVVWVL Q3U185_MOUSE Q3U185_MOUSE STVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSL-RWGRARYARGVAAVVWVL P2RY2_MOUSE P2RY2_MOUSE STVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSL-RWGRARYARRVAAVVWVL Q3U217_MOUSE Q3U217_MOUSE STVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSL-RWGRARYARRVAAVVWVL B5B287_RABIT B5B287_RABIT GAVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLLSL-RWGRARYARRVAAAVWVL P2RY2_HUMAN P2RY2_HUMAN STVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSL-RWGRARYARRVAGAVWVL Q5BJ79_XENTR Q5BJ79_XENTR GVALCKIVRFLFYANLYSSILFLTCISVHRYRGVCHPITTL-RCMNAKHAHVICALVWLS A9UMP2_XENLA A9UMP2_XENLA GEVLCKLVRFLFYANLYSSILFLTCISVHRYRGVCHPITSL-RRMNAKHAYVICALVWLS P2RY4_XENLA P2RY4_XENLA GEVLCKLVRFLFYANLYSSILFLTCISVHRYRGVCHPITSL-RRMNAKHAYVICALVWLS Q7ZWQ7_XENLA Q7ZWQ7_XENLA GEVLCKLVRFLFYANLYSSILFLTCISVHRYRGVCHPITSL-RRMNAKHAYVICALVWLS P2RY4_MOUSE P2RY4_MOUSE GTGFCKFVRFLFYWNLYCSVLFLTCISVHRYMGICHPLRAI-RWGRPRFAGLLCLGVWLV Q0VBT7_MOUSE Q0VBT7_MOUSE GTGFCKFVRFLFYWNLYCSVLFLTCISVHRYMGICHPLRAI-RWGRPRFAGLLCLGVWLV P2RY4_RAT P2RY4_RAT GTGLCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAI-RWGRPRFASLLCLGVWLV P2RY4_HUMAN P2RY4_HUMAN GTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAL-RWGRPRLAGLLCLAVWLV Q5DKX1_PIG Q5DKX1_PIG -------------------------------------LRVL-RWGRPRIASLLCLAVWLV O57466_MELGA O57466_MELGA GKVFCKIVRFLFYANLYSSILFLTCISVHRYMGICHPIRSL-KWVKTKHARLICVGVWLV Q4RP73_TETNG Q4RP73_TETNG GVAACKIVRFLFYVNLYCSILFLTCISVYRYVGICHPIKAL-NLVKPRHSYLVCASVWAV Q1LY72_DANRE Q1LY72_DANRE GVVLCKIVRFLFYANLYCSILFLTCISVHRYLGICHPIRSL-TLIKPRHAHMVCGFVWTA MATCH : : : . ** CONSENSUS G???CK??RF?F??NL??SILFLTCIS??RY?G???P????????????A??????VW??

Q9DE05_RAJER Q9DE05_RAJER VMAGISPILYFSRTGLRRNKTNTCYDTTSKELLETYFIYSMSTTFFGFCIPFATILVCYG Q4SPQ4_TETNG Q4SPQ4_TETNG VIVAISPILYYSRTGQKNNSTR-CYDTTTVDELPGYFIYSMVLTVLGFCVPFIIIFCCYG Q0V9S6_XENTR Q0V9S6_XENTR VIAGISPILFFSGTGIRKNKTITCFDTSSDEYLRSYFIYSMCTTVFGFCIPFILILGCYG Q90X57_XENLA Q90X57_XENLA VIAGISPILFFSGTGIRKNKTITCFDTSSDEYLRSYFIYSMCTTVFGFCIPFILILGCYG P2RY1_CHICK P2RY1_CHICK VVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYG P2RY1_MELGA P2RY1_MELGA VVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYG Q5XX73_CANFA Q5XX73_CANFA VALAISPILFYSGTQVRRNGTVTCYDSTSDEYLRSYFVYSMCTTVAMFCVPLVLILGCYG B5MBX7_HUMAN B5MBX7_HUMAN VVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYG P2RY1_RAT P2RY1_RAT VVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYG P2RY1_MOUSE P2RY1_MOUSE VVVAISPILFYSGTGTRKNKTVTCYDTTSNDYLRSYFIYSMCTTVAMFCIPLVLILGCYG Q544J5_MOUSE Q544J5_MOUSE VVVAISPILFYSGTGTRKNKTVTCYDTTSNDYLRSYFIYSMCTTVAMFCIPLVLILGCYG Q8BMJ5_MOUSE Q8BMJ5_MOUSE VVVAISPILFYSGTGTRKNKTVTCYDTTSNDYLRSYFIYSMCTTVAMFCIPLVLILGCYG P2RY1_CAVPO P2RY1_CAVPO VVVAISPILFYSGTGIRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYG P2RY1_BOVIN P2RY1_BOVIN VVVGISPILFYSGTGIRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYG B2R9U4_HUMAN B2R9U4_HUMAN VVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYG P2RY1_HUMAN P2RY1_HUMAN VVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYG P2RY6_MOUSE P2RY6_MOUSE VTAQCLPTAVFAATGIQRNRTV-CYDLSPPILSTRYLPYGMALTVIGFLLPFIALLACYC Q3UQ86_MOUSE Q3UQ86_MOUSE VTAQCLPTAVFAATGIQRNRTV-CYDLSPPILSTRYLPYGMALTVIGFLLPFIALLACYC P2RY6_RAT P2RY6_RAT VTAQCLPTAVFAATGIQRNRTV-CYDLSPPILSTRYLPYGMALTVIGFLLPFTALLACYC Q5YA26_PIG Q5YA26_PIG VTTQCLPTAHFAATGIQRNRTV-CYDLSPPSLATHYMPYGMALTVIGFLLPFGALLACYC P2RY6_HUMAN P2RY6_HUMAN VTTQCLPTAIFAATGIQRNRTV-CYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYC Q5R5L6_PONAB Q5R5L6_PONAB VTTQCLPTAIFAATGIQRNRTV-CYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYC P2RY3_CHICK P2RY3_CHICK VIAQCLPTFVFASTGTQRNRTV-CYDLSPPDRSTSYFPYGITLTITGFLLPFAAILACYC P2RY3_MELGA P2RY3_MELGA VIAQCLPTFVFASTGTQRNRTV-CYDLSPPDRSASYFPYGITLTITGFLLPFAAILACYC Q4SEL9_TETNG Q4SEL9_TETNG VIALCAPTFHFAETGIQRNRTV-CYDLSTPARSVDYYPYGMALTCLGFVLPFLGVMVCYC Q4SEL5_TETNG Q4SEL5_TETNG VLSCQSPVLYFSRIRDKNSSRI-CYDTTSPELFDDFLVYSSVISVLMFALPFMIVMVCNG Q6P852_XENTR Q6P852_XENTR VSACQSPILYFVTTSSNGDSTT-CHDTSSVDLFDNFVVYSTVDLALLFCVPFITIIICYC P2RY2_RAT P2RY2_RAT VLACQAPVLYFVTTSVRGTRIT-CHDTSARELFSHFVAYSSVMLGLLFAVPFSIILVCYV Q3U185_MOUSE Q3U185_MOUSE VLACQAPVLYFVTTSVRGTRIT-CHDTSARELFSHFVAYSSVMLGLLFAVPFSVILVCYV P2RY2_MOUSE P2RY2_MOUSE VLACQAPVLYFVTTSVRGTRIT-CHDTSARELFSHFVAYSSVMLGLLFAVPFSVILVCYV Q3U217_MOUSE Q3U217_MOUSE VLACQAPVLYFVTTSVRGTRIT-CHDTSARELFSHFVAYSSVMLGLLFAVPFSVILVCYV B5B287_RABIT B5B287_RABIT VLACQAPVLHFVTTSARGGRVT-CHDTSAPELFSRFMAYSSVMLGLLFALPFAVILVCYV P2RY2_HUMAN P2RY2_HUMAN VLACQAPVLYFVTTSARGGRVT-CHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYV Q5BJ79_XENTR Q5BJ79_XENTR VMLCLVPNLMFVTVSPKVNGTI-CHDTTLPEEFDKYVEYSTGIMCLLFGIPCLIIACCYG A9UMP2_XENLA A9UMP2_XENLA VTLCLVPNLIFVTVSPKVKNTI-CHDTTRPEDFARYVEYSTAIMCLLFGIPCLIIAGCYG P2RY4_XENLA P2RY4_XENLA VTLCLVPNLIFVTVSPKVKNTI-CHDTTRPEDFARYVEYSTAIMCLLFGIPCLIIAGCYG Q7ZWQ7_XENLA Q7ZWQ7_XENLA VTLCLVPNLIFVTVSPKVKNTI-CHDTTRPEDFARYVEYSTAIMCLLFGIPCLIIAGCYG P2RY4_MOUSE P2RY4_MOUSE VAGCLVPNLFFVTTNANGTTIL-CHDTTLPEEFDHYVYFSSTIMVLLFGFPFLITLVCYG Q0VBT7_MOUSE Q0VBT7_MOUSE VAGCLVPNLFFVTTNANGTTIL-CHDTTLPEEFDHYVYFSSTIMVLLFGFPFLITLVCYG P2RY4_RAT P2RY4_RAT VAGCLVPNLFFVTTNANGTTIL-CHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYG P2RY4_HUMAN P2RY4_HUMAN VAGCLVPNLFFVTTSNKGTTVL-CHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYG Q5DKX1_PIG Q5DKX1_PIG VAGCLVPNLFFVTTSTKGDTIL-CHDTTRPEEFDHYVHFSSAVMGLLFGVPCVVTLVCYG O57466_MELGA O57466_MELGA VTICLIPNLIFVTTSSKDNSTL-CHDTTKPEEFDHYVHYSSSIMALLFGIPFLVIVVCYC Q4RP73_TETNG Q4RP73_TETNG VIVCLVPNLIFVTTSRRDNITL-CHDTTSPELFLQYVNYCSVVMVFLFGIPFLVIVVCYC Q1LY72_DANRE Q1LY72_DANRE VIACLVPTLILVNTSRNGNSTL-CHDTSRPEEFHNFVTYNSVVMVLLFILPFLVIVVCYC MATCH * * . *.* : : : * .* * CONSENSUS V?????P?L????T?????????C?D?????????Y??Y????????F??P??????CY?

Q9DE05_RAJER Q9DE05_RAJER FIVKALI---SNDM------KTP-LRGKSVRLVIIVLAVFAISYLPFHVMKNLNLQSRLY Q4SPQ4_TETNG Q4SPQ4_TETNG MIVKVLI---SKDMNNDIINNAP-LRQKSIYLVIIVLVVFAVSYLPFHVMKNLNMRARLY Q0V9S6_XENTR Q0V9S6_XENTR LIVRALI---YKDM-----NNAP-LRKKSIYLVIIVLTVFAVSYLPFHVMKNLNLRARLD Q90X57_XENLA Q90X57_XENLA LIVRALI---YKDM-----NNAP-LRKKSIYLVIIVLTVFAVSYLPFHVMKNLNLRARLD P2RY1_CHICK P2RY1_CHICK LIVKALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLD P2RY1_MELGA P2RY1_MELGA LIVKALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLD Q5XX73_CANFA Q5XX73_CANFA LIVRALI---YKDL-----DDSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD B5MBX7_HUMAN B5MBX7_HUMAN LIVRALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD P2RY1_RAT P2RY1_RAT LIVRALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD P2RY1_MOUSE P2RY1_MOUSE LIVKALI---YNDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD Q544J5_MOUSE Q544J5_MOUSE LIVKALI---YNDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD Q8BMJ5_MOUSE Q8BMJ5_MOUSE LIVKALI---YNDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD P2RY1_CAVPO P2RY1_CAVPO LIVRALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD P2RY1_BOVIN P2RY1_BOVIN LIVRALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD B2R9U4_HUMAN B2R9U4_HUMAN LIVRALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD P2RY1_HUMAN P2RY1_HUMAN LIVRALI---YKDL-----DNSP-LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLD P2RY6_MOUSE P2RY6_MOUSE RMARRLC---RQDG--PAGPVAQERRSKAARMAVVVAAVFAISFLPFHITKTAYLAVRST Q3UQ86_MOUSE Q3UQ86_MOUSE RMARRLC---RQDG--PAGPVAQERRSKAARMAVVVAAVFAISFLPFHITKTAYLAVRST P2RY6_RAT P2RY6_RAT RMARRLC---RQDG--PAGPVAQERRSKAARMAVVVAAVFVISFLPFHITKTAYLAVRST Q5YA26_PIG Q5YA26_PIG RLARRLC---RRDG--PAGPVAQERRDKAARMAVVVAAAFAISFLPFHITKTAYLAVRST P2RY6_HUMAN P2RY6_HUMAN LLACRLC---RQDG--PAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRST Q5R5L6_PONAB Q5R5L6_PONAB LLARRLC---RQDG--PAEPVAQERRGTAARMAVVVAAAFAISFLPFHITKTAYLAVRST P2RY3_CHICK P2RY3_CHICK SMARILC---QKDE-LIGLAVHK-KKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSS P2RY3_MELGA P2RY3_MELGA SMARILC---QKDE-LIGLAVHK-KKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSS Q4SEL9_TETNG Q4SEL9_TETNG RMAQILC---RPVSYRGVSMATGEKRDKAVKMIIVVAAVFCISFLPFHFTKTVYMMVRSI Q4SEL5_TETNG Q4SEL5_TETNG LMVRKLLEVSWRSGAKRGNLSARQSRQKSVKMIIIVLATFMLCFLPFHLTRSLYYSFRYI Q6P852_XENTR Q6P852_XENTR LMARTLM---KPSA--ATAQTSA-SKKKSIKMIIIVLAVFIICFLPFHINRTLYYYFRKM P2RY2_RAT P2RY2_RAT LMARRLL---KPAY--GTTGLPR-AKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSL Q3U185_MOUSE Q3U185_MOUSE LMARRLL---KPAY-GTTGGLPR-AKRKSVRTIALVLAVFALCFLPFHVARTLYYSFRSL P2RY2_MOUSE P2RY2_MOUSE LMARRLL---KPAY-GTTGGLPR-AKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSL Q3U217_MOUSE Q3U217_MOUSE LMARRLL---KPAY-GTTGGLPR-AKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSL B5B287_RABIT B5B287_RABIT LMARRLL---RPAY-GTTGGLPR-AKRKSVRTIAVVLAVFAICFLPFHVTRTLYYSFRSL P2RY2_HUMAN P2RY2_HUMAN LMARRLL---KPAY-GTSGGLPR-AKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSL Q5BJ79_XENTR Q5BJ79_XENTR LMARELM---KPLVNGNHQTLPS-YKKRSIKTIVIVMIAFAICFMPFHITRTLYYYARLL A9UMP2_XENLA A9UMP2_XENLA LMTRELM---KPIVSGNQQTLPS-YKKRSIKTIIFVMIAFAICFMPFHITRTLYYYARLL P2RY4_XENLA P2RY4_XENLA LMTRELM---KPIVSGNQQTLPS-YKKRSIKTIIFVMIAFAICFMPFHITRTLYYYARLL Q7ZWQ7_XENLA Q7ZWQ7_XENLA LMTRELM---KPIVSGNQQTLPS-YKKRSIKTIIFVMIAFAICFMPFHITRTLYYYARLL P2RY4_MOUSE P2RY4_MOUSE LMARRL----YRPL--PGAGQSS-SRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLL Q0VBT7_MOUSE Q0VBT7_MOUSE LMARRL----YRPL--PGAGQSS-SRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLL P2RY4_RAT P2RY4_RAT LMARRL----YRPL--PGAGQSS-SRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLL P2RY4_HUMAN P2RY4_HUMAN LMARRL----YQPL--PGSAQSS-SRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLL Q5DKX1_PIG Q5DKX1_PIG LMARRL----YQPL--PGAAQSS-TRVRSLRTIAVVLTVFAICFVPFHITRTVYYLARLL O57466_MELGA O57466_MELGA LMAKRLC---KRSFPSPSPRVPS-YKKRSIKMIIIVLTVFAICFVPFHITRTLYYTSRYF Q4RP73_TETNG Q4RP73_TETNG LMARTLC---RPRVGLSSRQQGAVSYQKTLKLIIMVLVMFAMCFVPFHVTRTLYYVARLA Q1LY72_DANRE Q1LY72_DANRE LMARALC---QPRKGLAQNQQSS-SRKKSIKLIIVVLVVFAICFVPFHITRTLYYAYRIF MATCH :. * : .* * :.:.***. :. * CONSENSUS L????L?????????????????????????????V??VFA????PFH???T?????R??

Q9DE05_RAJER Q9DE05_RAJER YQG---LDTCEWNRRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRFTNAASR-FM-- Q4SPQ4_TETNG Q4SPQ4_TETNG FQT---PDMCEFNNRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRKLSRATKK-N--- Q0V9S6_XENTR Q0V9S6_XENTR FQS---PEMCNFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRKLSRATRK-A--- Q90X57_XENLA Q90X57_XENLA FQS---PEMCNFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRKLSRATRK-A--- P2RY1_CHICK P2RY1_CHICK FQT---PQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-S--- P2RY1_MELGA P2RY1_MELGA FQT---PQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-S--- Q5XX73_CANFA Q5XX73_CANFA FQT---PDMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- B5MBX7_HUMAN B5MBX7_HUMAN FQT---PAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- P2RY1_RAT P2RY1_RAT FQT---PEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- P2RY1_MOUSE P2RY1_MOUSE FQT---PEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- Q544J5_MOUSE Q544J5_MOUSE FQT---PEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- Q8BMJ5_MOUSE Q8BMJ5_MOUSE FQT---PEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- P2RY1_CAVPO P2RY1_CAVPO FQT---PEMCTFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- P2RY1_BOVIN P2RY1_BOVIN FQT---PEMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- B2R9U4_HUMAN B2R9U4_HUMAN FQT---PAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- P2RY1_HUMAN P2RY1_HUMAN FQT---PAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRK-A--- P2RY6_MOUSE P2RY6_MOUSE P-----GVSCPVLETFAAAYKGTRPFASVNSVLDPILFYFTQQKFRRQPHDLLQR----- Q3UQ86_MOUSE Q3UQ86_MOUSE P-----GVSCPVLETFAAAYKGTRPFASVNSVLDPILFYFTQQKFRRQPHDLLQR----- P2RY6_RAT P2RY6_RAT P-----GVSCPVLETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHDLLQK----- Q5YA26_PIG Q5YA26_PIG P-----GVPCPVLEAFAAAYKGTRPFASANSVLD-------------------------- P2RY6_HUMAN P2RY6_HUMAN P-----GVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQK----- Q5R5L6_PONAB Q5R5L6_PONAB P-----GVPCPVLEAFAAAYKSTRPFASANSVLDPILFYFTQKKFRRRPHELLQK----- P2RY3_CHICK P2RY3_CHICK A-----SLPCPTLQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDK----- P2RY3_MELGA P2RY3_MELGA P-----TLPCPTLQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDK----- Q4SEL9_TETNG Q4SEL9_TETNG Q-----GMPCTTRNLFSVIYKSTRPFASMNSFLDPILFYFTQPRYRQSTRRFVLR----- Q4SEL5_TETNG Q4SEL5_TETNG RQVNPHQITCGMLEAINVAYKVTRPLASANSCLDPILYFLAGQDIRSNLTKKC------- Q6P852_XENTR Q6P852_XENTR ------ELDCDILNAINLAYKVTRPLASANSCLDPILYFLAGQTVRRSI----------- P2RY2_RAT P2RY2_RAT ------DLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAG----QRLVRFARD-A--- Q3U185_MOUSE Q3U185_MOUSE ------DLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAG----QRLVRFARD-A--- P2RY2_MOUSE P2RY2_MOUSE ------DLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAG----QRLVRFARD-A--- Q3U217_MOUSE Q3U217_MOUSE ------DLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAG----QRLVRFARD-A--- B5B287_RABIT B5B287_RABIT ------DLSCHTLNAVNMAYKVTRPLASANSCLDPV------------------------ P2RY2_HUMAN P2RY2_HUMAN ------DLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAG----QRLVRFARD-A--- Q5BJ79_XENTR Q5BJ79_XENTR ------GVNCYALNVINFTYKITRPLASANSCIDPILYFLANDRYRRRLIRTV-R-RSSV A9UMP2_XENLA A9UMP2_XENLA ------GIKCYALNVINVTYKVTRPLASANSCIDPILYFLANDRYRRRLIRTVRR-RSSV P2RY4_XENLA P2RY4_XENLA ------GIKCYALNVINVTYKVTRPLASANSCIDPILYFLANDRYRRRLIRTVRR-RSSV Q7ZWQ7_XENLA Q7ZWQ7_XENLA ------GIKCYALNVINVTYKVTRPLASANSCIDPILYFLANDRYRRRLIRTVRR-RSSV P2RY4_MOUSE P2RY4_MOUSE ------NAECRVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRG-S--- Q0VBT7_MOUSE Q0VBT7_MOUSE ------NAECRVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRG-S--- P2RY4_RAT P2RY4_RAT ------QADCHVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRG-S--- P2RY4_HUMAN P2RY4_HUMAN ------EADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGG-G--- Q5DKX1_PIG Q5DKX1_PIG ------EADCWVLNIVNVVYKVTRPLASANSCLDPV------------------------ O57466_MELGA O57466_MELGA ------QADCQTLNIINFTYKITRPLASINSCLDPILYFMAGDKYRGRLRRGAAQRPRPV Q4RP73_TETNG Q4RP73_TETNG ------KPSCDTLNAINFTYKITRPLVCVNSCVDPILYFLAGDSYRSRLI---------- Q1LY72_DANRE Q1LY72_DANRE ------DADCKTLNIVNFSYKITRPLASVNSCLDPILYFLAGDHYRSKLLRVLTR-QTPN MATCH * . *: ** :.. ** :* CONSENSUS ?????????C?????????Y??TR?LAS?NSC?DP?L????????R??????????????

Q9DE05_RAJER Q9DE05_RAJER -------------TRRSELSMQFRS-EDSPLQ--PV------------------------ Q4SPQ4_TETNG Q4SPQ4_TETNG -------------SRKGDHILQSKS-EETALN--SL------------------------ Q0V9S6_XENTR Q0V9S6_XENTR -------------SRRSEANVQSKS-EEMTLN--IL------------------------ Q90X57_XENLA Q90X57_XENLA -------------SRRSEANVQSKS-EEVTLN--IL------------------------ P2RY1_CHICK P2RY1_CHICK -------------SRRSEPNVQSKS-EEMTLN--IL------------------------ P2RY1_MELGA P2RY1_MELGA -------------SRRSEPNVQSKS-EEMTLN--IL------------------------ Q5XX73_CANFA Q5XX73_CANFA -------------SRRSEANLQSKS-EDMTLN--IL------------------------ B5MBX7_HUMAN B5MBX7_HUMAN -------------SRRSEANLQSKKISSMVYNKTLN------------------------ P2RY1_RAT P2RY1_RAT -------------SRRSEANLQSKS-EEMTLN--IL------------------------ P2RY1_MOUSE P2RY1_MOUSE -------------SRRSEANLQSKS-EEMTLN--IL------------------------ Q544J5_MOUSE Q544J5_MOUSE -------------SRRSEANLQSKS-EEMTLN--IL------------------------ Q8BMJ5_MOUSE Q8BMJ5_MOUSE -------------SRRSEANLQSKS-EEMTLN--IL------------------------ P2RY1_CAVPO P2RY1_CAVPO -------------SRRSEANLQSKS-EDMTLN--IL------------------------ P2RY1_BOVIN P2RY1_BOVIN -------------SRRSEANLQSKS-EDMTLN--IL------------------------ B2R9U4_HUMAN B2R9U4_HUMAN -------------SRRSEANLQSKS-EDMTLN--IL------------------------ P2RY1_HUMAN P2RY1_HUMAN -------------SRRSEANLQSKS-EDMTLN--IL------------------------ P2RY6_MOUSE P2RY6_MOUSE ----------------------------------LT------------------------ Q3UQ86_MOUSE Q3UQ86_MOUSE ----------------------------------LT------------------------ P2RY6_RAT P2RY6_RAT ----------------------------------LT------------------------ Q5YA26_PIG Q5YA26_PIG ------------------------------------------------------------ P2RY6_HUMAN P2RY6_HUMAN ----------------------------------LT------------------------ Q5R5L6_PONAB Q5R5L6_PONAB ----------------------------------LT------------------------ P2RY3_CHICK P2RY3_CHICK ----------------------------MS------------------------------ P2RY3_MELGA P2RY3_MELGA ----------------------------MS------------------------------ Q4SEL9_TETNG Q4SEL9_TETNG ----------------------------V-TT---------------------------- Q4SEL5_TETNG Q4SEL5_TETNG ------------------------------------------------------------ Q6P852_XENTR Q6P852_XENTR -------------IPRNGLSKMKNKFTSYVLE---------------------------- P2RY2_RAT P2RY2_RAT -------------KPATEPTPSPQARRKLGLHRPNRTDTVR------------------- Q3U185_MOUSE Q3U185_MOUSE -------------KPPTEPTPSPQACRKLGLHRPNRTVR--------------------- P2RY2_MOUSE P2RY2_MOUSE -------------KPPTEPTPSPQARRKLGLHRPNRTVR--------------------- Q3U217_MOUSE Q3U217_MOUSE -------------KPPTEPTPSPQACRKLGLHRPNRTVR--------------------- B5B287_RABIT B5B287_RABIT ------------------------------------------------------------ P2RY2_HUMAN P2RY2_HUMAN -------------KPPTGPSPATPARRRLGLRRSDRTDMQRI------------------ Q5BJ79_XENTR Q5BJ79_XENTR HHRRCMHTNHPGPHPEPEPHMTTGPLPVVSAE--ETQSNGRMVRDENEEGAREHRVGWTA A9UMP2_XENLA A9UMP2_XENLA PNRRCMHTN----HPQTEPHMTAGPLPVISAE--EIPSNGSMVRDENGEGSREHRVEWTD P2RY4_XENLA P2RY4_XENLA PNRRCMHTN----HPQTEPHMTAGPLPVISAE--EIPSNGSMVRDENGEGSREHRVEWTD Q7ZWQ7_XENLA Q7ZWQ7_XENLA PNRRCMHTN----HPQTEPHMTAGPLPVISAE--EIPSNGSMVRDENGEGSREHRVEWTD P2RY4_MOUSE P2RY4_MOUSE -------------TPKRRTTASSLALVTLHEE--SI------------------------ Q0VBT7_MOUSE Q0VBT7_MOUSE -------------TPKRRTTASSLALVTLHEE--SI------------------------ P2RY4_RAT P2RY4_RAT -------------KPKPRTAASSLALVTLHEE--SI------------------------ P2RY4_HUMAN P2RY4_HUMAN -------------KPQPRTAASSLALVSLPED--SS------------------------ Q5DKX1_PIG Q5DKX1_PIG ------------------------------------------------------------ O57466_MELGA O57466_MELGA PTSLLALV-----SPSVDSSVVGSCCNSESRG--MG------------------------ Q4RP73_TETNG Q4RP73_TETNG ------------------------------------------------------------ Q1LY72_DANRE Q1LY72_DANRE TR-----------STAYEYAPNGKNIELAFKN---------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q9DE05_RAJER Q9DE05_RAJER ------------------------------------------------------------ Q4SPQ4_TETNG Q4SPQ4_TETNG ------------------------------------------------------------ Q0V9S6_XENTR Q0V9S6_XENTR ------------------------------------------------------------ Q90X57_XENLA Q90X57_XENLA ------------------------------------------------------------ P2RY1_CHICK P2RY1_CHICK ------------------------------------------------------------ P2RY1_MELGA P2RY1_MELGA ------------------------------------------------------------ Q5XX73_CANFA Q5XX73_CANFA ------------------------------------------------------------ B5MBX7_HUMAN B5MBX7_HUMAN ------------------------------------------------------------ P2RY1_RAT P2RY1_RAT ------------------------------------------------------------ P2RY1_MOUSE P2RY1_MOUSE ------------------------------------------------------------ Q544J5_MOUSE Q544J5_MOUSE ------------------------------------------------------------ Q8BMJ5_MOUSE Q8BMJ5_MOUSE ------------------------------------------------------------ P2RY1_CAVPO P2RY1_CAVPO ------------------------------------------------------------ P2RY1_BOVIN P2RY1_BOVIN ------------------------------------------------------------ B2R9U4_HUMAN B2R9U4_HUMAN ------------------------------------------------------------ P2RY1_HUMAN P2RY1_HUMAN ------------------------------------------------------------ P2RY6_MOUSE P2RY6_MOUSE ------------------------------------------------------------ Q3UQ86_MOUSE Q3UQ86_MOUSE ------------------------------------------------------------ P2RY6_RAT P2RY6_RAT ------------------------------------------------------------ Q5YA26_PIG Q5YA26_PIG ------------------------------------------------------------ P2RY6_HUMAN P2RY6_HUMAN ------------------------------------------------------------ Q5R5L6_PONAB Q5R5L6_PONAB ------------------------------------------------------------ P2RY3_CHICK P2RY3_CHICK ------------------------------------------------------------ P2RY3_MELGA P2RY3_MELGA ------------------------------------------------------------ Q4SEL9_TETNG Q4SEL9_TETNG ------------------------------------------------------------ Q4SEL5_TETNG Q4SEL5_TETNG ------------------------------------------------------------ Q6P852_XENTR Q6P852_XENTR ------------------------------------------------------------ P2RY2_RAT P2RY2_RAT ------------------------------------------------------------ Q3U185_MOUSE Q3U185_MOUSE ------------------------------------------------------------ P2RY2_MOUSE P2RY2_MOUSE ------------------------------------------------------------ Q3U217_MOUSE Q3U217_MOUSE ------------------------------------------------------------ B5B287_RABIT B5B287_RABIT ------------------------------------------------------------ P2RY2_HUMAN P2RY2_HUMAN ------------------------------------------------------------ Q5BJ79_XENTR Q5BJ79_XENTR SKDSKQRKSVYHQSTIKRNSMDKNNMKEHRHGENYLPHVEVVEKEDYVTEGENRKTTGQG A9UMP2_XENLA A9UMP2_XENLA TKEINQM--MNRRSTIKRNSTDKNDMKENRHGENYLPYVEVVEKEDYETKQENRKTTEQ- P2RY4_XENLA P2RY4_XENLA TKEINQM--MNRRSTIKRNSTDKNDMKENRHGENYLPYVEVVEKEDYETKRENRKTTEQ- Q7ZWQ7_XENLA Q7ZWQ7_XENLA TKEINQM--MNRRSTIKRNSTDKNDMKENRHGENYLPYVEVVEKEDYETKQENRKTTEQ- P2RY4_MOUSE P2RY4_MOUSE ------------------------------------------------------------ Q0VBT7_MOUSE Q0VBT7_MOUSE ------------------------------------------------------------ P2RY4_RAT P2RY4_RAT ------------------------------------------------------------ P2RY4_HUMAN P2RY4_HUMAN ------------------------------------------------------------ Q5DKX1_PIG Q5DKX1_PIG ------------------------------------------------------------ O57466_MELGA O57466_MELGA ------------------------------------------------------------ Q4RP73_TETNG Q4RP73_TETNG ------------------------------------------------------------ Q1LY72_DANRE Q1LY72_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q9DE05_RAJER Q9DE05_RAJER -------------------------SNISQNGDTSL------------------------ Q4SPQ4_TETNG Q4SPQ4_TETNG -------------------------AENVENGERRL------------------------ Q0V9S6_XENTR Q0V9S6_XENTR -------------------------SEYKQNGDTSL------------------------ Q90X57_XENLA Q90X57_XENLA -------------------------SEYKQNGDTSL------------------------ P2RY1_CHICK P2RY1_CHICK -------------------------TEYKQNGDTSL------------------------ P2RY1_MELGA P2RY1_MELGA -------------------------TEYKQNGDTSL------------------------ Q5XX73_CANFA Q5XX73_CANFA -------------------------SEFKQNGDTSL------------------------ B5MBX7_HUMAN B5MBX7_HUMAN -------------------------SSVHPASDQWISER--------------------- P2RY1_RAT P2RY1_RAT -------------------------SEFKQNGDTSL------------------------ P2RY1_MOUSE P2RY1_MOUSE -------------------------SEFKQNGDTSL------------------------ Q544J5_MOUSE Q544J5_MOUSE -------------------------SEFKQNGDTSL------------------------ Q8BMJ5_MOUSE Q8BMJ5_MOUSE -------------------------SEFKQNGDTSL------------------------ P2RY1_CAVPO P2RY1_CAVPO -------------------------SEFKQNGDTSL------------------------ P2RY1_BOVIN P2RY1_BOVIN -------------------------SEFKQNGDTSL------------------------ B2R9U4_HUMAN B2R9U4_HUMAN -------------------------PEFKQNGDTSL------------------------ P2RY1_HUMAN P2RY1_HUMAN -------------------------PEFKQNGDTSL------------------------ P2RY6_MOUSE P2RY6_MOUSE -------------------------AKWQRQRV--------------------------- Q3UQ86_MOUSE Q3UQ86_MOUSE -------------------------AKWQRQRV--------------------------- P2RY6_RAT P2RY6_RAT -------------------------AKWQRQRV--------------------------- Q5YA26_PIG Q5YA26_PIG ------------------------------------------------------------ P2RY6_HUMAN P2RY6_HUMAN -------------------------AKWQRQGR--------------------------- Q5R5L6_PONAB Q5R5L6_PONAB -------------------------AKWQRQGR--------------------------- P2RY3_CHICK P2RY3_CHICK -------------------------SKWRQDHCISYGS---------------------- P2RY3_MELGA P2RY3_MELGA -------------------------SKWRHDHCITYGS---------------------- Q4SEL9_TETNG Q4SEL9_TETNG ------------------------------------------------------------ Q4SEL5_TETNG Q4SEL5_TETNG ------------------------------------------------------------ Q6P852_XENTR Q6P852_XENTR -------------------------NNWSGSATGVSNSEARQSPAVISKV---------- P2RY2_RAT P2RY2_RAT -------------------------KDLSISSDDSRRTESTPAGSETKDIRL-------- Q3U185_MOUSE Q3U185_MOUSE -------------------------KDLSVSSDDSRRTESTPAGSETKDIRL-------- P2RY2_MOUSE P2RY2_MOUSE -------------------------KDLSVSSDDSRRTESTPAGSETKDIRL-------- Q3U217_MOUSE Q3U217_MOUSE -------------------------KDLSVSSDDSRRTESTPAGSETKDIRL-------- B5B287_RABIT B5B287_RABIT ------------------------------------------------------------ P2RY2_HUMAN P2RY2_HUMAN -------------------------EDVLGSSEDSRRTESTPAGSENTKDIRL------- Q5BJ79_XENTR Q5BJ79_XENTR DIAESRKTNDEQDEIQTQISSSLKKGKWRLSSKKGATQEYEEGHVESSWEAEGTSTWNLL A9UMP2_XENLA A9UMP2_XENLA ----SSKTNAEQDELQTQIDSRLKRGKWQLSSKKGAAQEDEKGHMEPSFEGEGTSTWNLL P2RY4_XENLA P2RY4_XENLA ----SSKTNAEQDELQTQIDSRLKRGKWQLSSKKGAAQENEKGHMEPSFEGEGTSTWNLL Q7ZWQ7_XENLA Q7ZWQ7_XENLA ----SSKTNAEQDELQTQIDSRLKRGKWQLSSKKGAAQENEKGHMEPSFEGEGTSTWNLL P2RY4_MOUSE P2RY4_MOUSE -------------------------SRWADIHQDSIFPAYEGDRL--------------- Q0VBT7_MOUSE Q0VBT7_MOUSE -------------------------SRWADIHQDSIFPAYEGDRL--------------- P2RY4_RAT P2RY4_RAT -------------------------SRWADTHQDSTFSAYEGDRL--------------- P2RY4_HUMAN P2RY4_HUMAN -------------------------CRWAATPQDSSCSTPRADRL--------------- Q5DKX1_PIG Q5DKX1_PIG ------------------------------------------------------------ O57466_MELGA O57466_MELGA -------------------------TVWSRGGQ--------------------------- Q4RP73_TETNG Q4RP73_TETNG ------------------------------------------------------------ Q1LY72_DANRE Q1LY72_DANRE -------------------------PDAQAGSDSRL------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q9DE05_RAJER Q9DE05_RAJER -------------------------------- Q4SPQ4_TETNG Q4SPQ4_TETNG -------------------------------- Q0V9S6_XENTR Q0V9S6_XENTR -------------------------------- Q90X57_XENLA Q90X57_XENLA -------------------------------- P2RY1_CHICK P2RY1_CHICK -------------------------------- P2RY1_MELGA P2RY1_MELGA -------------------------------- Q5XX73_CANFA Q5XX73_CANFA -------------------------------- B5MBX7_HUMAN B5MBX7_HUMAN -------------------------------- P2RY1_RAT P2RY1_RAT -------------------------------- P2RY1_MOUSE P2RY1_MOUSE -------------------------------- Q544J5_MOUSE Q544J5_MOUSE -------------------------------- Q8BMJ5_MOUSE Q8BMJ5_MOUSE -------------------------------- P2RY1_CAVPO P2RY1_CAVPO -------------------------------- P2RY1_BOVIN P2RY1_BOVIN -------------------------------- B2R9U4_HUMAN B2R9U4_HUMAN -------------------------------- P2RY1_HUMAN P2RY1_HUMAN -------------------------------- P2RY6_MOUSE P2RY6_MOUSE -------------------------------- Q3UQ86_MOUSE Q3UQ86_MOUSE -------------------------------- P2RY6_RAT P2RY6_RAT -------------------------------- Q5YA26_PIG Q5YA26_PIG -------------------------------- P2RY6_HUMAN P2RY6_HUMAN -------------------------------- Q5R5L6_PONAB Q5R5L6_PONAB -------------------------------- P2RY3_CHICK P2RY3_CHICK -------------------------------- P2RY3_MELGA P2RY3_MELGA -------------------------------- Q4SEL9_TETNG Q4SEL9_TETNG -------------------------------- Q4SEL5_TETNG Q4SEL5_TETNG -------------------------------- Q6P852_XENTR Q6P852_XENTR -------------------------------- P2RY2_RAT P2RY2_RAT -------------------------------- Q3U185_MOUSE Q3U185_MOUSE -------------------------------- P2RY2_MOUSE P2RY2_MOUSE -------------------------------- Q3U217_MOUSE Q3U217_MOUSE -------------------------------- B5B287_RABIT B5B287_RABIT -------------------------------- P2RY2_HUMAN P2RY2_HUMAN -------------------------------- Q5BJ79_XENTR Q5BJ79_XENTR TPKMYSKKDRLAKNVEGESYWKERELQNIPKI A9UMP2_XENLA A9UMP2_XENLA TPKMYGKKDRLAKNVEEVGYVKEKELQNFPRA P2RY4_XENLA P2RY4_XENLA TPKMYGKKDRLAKNVEEVGYGKEKELQNFPKA Q7ZWQ7_XENLA Q7ZWQ7_XENLA TPKMYGKKDRLAKNVEEVGYGKEKELQNFPKA P2RY4_MOUSE P2RY4_MOUSE -------------------------------- Q0VBT7_MOUSE Q0VBT7_MOUSE -------------------------------- P2RY4_RAT P2RY4_RAT -------------------------------- P2RY4_HUMAN P2RY4_HUMAN -------------------------------- Q5DKX1_PIG Q5DKX1_PIG -------------------------------- O57466_MELGA O57466_MELGA -------------------------------- Q4RP73_TETNG Q4RP73_TETNG -------------------------------- Q1LY72_DANRE Q1LY72_DANRE -------------------------------- MATCH CONSENSUS ????????????????????????????????


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