Alignment of the gene Family HBG105663 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q5FZN8_BRABE Q5FZN8_BRABE ------------------------------------------------------------ Q9NB28_BRAFL Q9NB28_BRAFL ------------------------------------------------------------ Q86SB8_HALRO Q86SB8_HALRO ------------------------------------------------------------ Q4S778_TETNG Q4S778_TETNG ------------------------------------------------------------ Q0Q579_BRAFL Q0Q579_BRAFL ------------------------------------------------------------ SX19A_DANRE SX19A_DANRE ------------------------------------------------------------ SX19B_DANRE SX19B_DANRE ------------------------------------------------------------ Q6I753_CYNPY Q6I753_CYNPY ------------------------------------------------------------ O57401_CHICK O57401_CHICK ------------------------------------------------------------ SOX1_MOUSE SOX1_MOUSE ------------------------------------------------------------ Q80XF2_MOUSE Q80XF2_MOUSE ------------------------------------------------------------ SOX1_HUMAN SOX1_HUMAN ------------------------------------------------------------ SOX1B_DANRE SOX1B_DANRE ------------------------------------------------------------ Q4S0P5_TETNG Q4S0P5_TETNG ------------------------------------------------------------ SOX1A_DANRE SOX1A_DANRE ------------------------------------------------------------ SOX2_XENLA SOX2_XENLA ------------------------------------------------------------ SOX2_CHICK SOX2_CHICK ------------------------------------------------------------ B4YQU0_BUBBU B4YQU0_BUBBU ------------------------------------------------------------ B6VA41_HORSE B6VA41_HORSE ------------------------------------------------------------ SOX2_MOUSE SOX2_MOUSE ------------------------------------------------------------ B1Q0D1_PIG B1Q0D1_PIG ------------------------------------------------------------ Q3UES8_MOUSE Q3UES8_MOUSE ------------------------------------------------------------ Q3V2B6_MOUSE Q3V2B6_MOUSE ------------------------------------------------------------ Q60I23_MOUSE Q60I23_MOUSE ------------------------------------------------------------ B2R6J0_HUMAN B2R6J0_HUMAN ------------------------------------------------------------ A2VDX8_BOVIN A2VDX8_BOVIN ------------------------------------------------------------ B8XIA2_MACMU B8XIA2_MACMU ------------------------------------------------------------ SOX2_HUMAN SOX2_HUMAN ------------------------------------------------------------ SOX2_SHEEP SOX2_SHEEP ------------------------------------------------------------ B1PXF9_PIG B1PXF9_PIG ------------------------------------------------------------ Q38Q18_PIG Q38Q18_PIG ------------------------------------------------------------ Q08G14_ACISC Q08G14_ACISC ------------------------------------------------------------ B5X176_SALSA B5X176_SALSA ------------------------------------------------------------ B5LEE1_9TELE B5LEE1_9TELE ------------------------------------------------------------ SOX2_DANRE SOX2_DANRE ------------------------------------------------------------ Q09HM9_GADMO Q09HM9_GADMO ------------------------------------------------------------ A4GU07_OREMO A4GU07_OREMO ------------------------------------------------------------ Q4T665_TETNG Q4T665_TETNG ------------------------------------------------------------ B7U506_EPICO B7U506_EPICO ------------------------------------------------------------ A4GU04_ORENI A4GU04_ORENI ------------------------------------------------------------ A4GU05_OREAU A4GU05_OREAU ------------------------------------------------------------ A4GU06_9CICH A4GU06_9CICH ------------------------------------------------------------ Q28848_SMIMA Q28848_SMIMA ------------------------------------------------------------ SOX3_HUMAN SOX3_HUMAN RPVRENSSGARSPRVPADLARSILISLPFPPDSLAHRPPSSAPTESQGLFTVAAPAPGAP SOX3_MOUSE SOX3_MOUSE ------------------------------------------------------------ Q6P564_MOUSE Q6P564_MOUSE -PARENASGERSPRVPADFARSPSASLPFPPELPARRPLSTTPTESPGLFTVAAPAPGAP Q5RKW0_MOUSE Q5RKW0_MOUSE RPARENASGERSPRVPADFARSPSASLPFPPELPARRPLSTTPTESPGLFTVAAPAPGAP Q4VBD8_MOUSE Q4VBD8_MOUSE -------------RVPADFARSPSASLPFPPELPARRPLSTTPTESPGLFTVAAPAPGAP A2AM37_MOUSE A2AM37_MOUSE RPARENASGERSPRVPADFARSPSASLPFPPELPARRPLSTTPTESPGLFTVAAPAPGAP Q80XF1_MOUSE Q80XF1_MOUSE ------------------------------------------------------------ B7T0X1_RAT B7T0X1_RAT ------------------------------------------------------------ Q4RP71_TETNG Q4RP71_TETNG ------------------------------------------------------------ A5Z1E1_ACASC A5Z1E1_ACASC ------------------------------------------------------------ Q9PT76_ORYLA Q9PT76_ORYLA ------------------------------------------------------------ Q06B63_LATCA Q06B63_LATCA ------------------------------------------------------------ Q38KZ5_EPICO Q38KZ5_EPICO ------------------------------------------------------------ B5LSX2_9LABR B5LSX2_9LABR ------------------------------------------------------------ A2I8A8_CARAU A2I8A8_CARAU ------------------------------------------------------------ A9JSZ3_DANRE A9JSZ3_DANRE ------------------------------------------------------------ SOX3_DANRE SOX3_DANRE ------------------------------------------------------------ SOX3_CHICK SOX3_CHICK ------------------------------------------------------------ Q2F7Y8_TAEGU Q2F7Y8_TAEGU ------------------------------------------------------------ Q9PSV6_CHICK Q9PSV6_CHICK ------------------------------------------------------------ SOX3B_XENLA SOX3B_XENLA ------------------------------------------------------------ SOX3A_XENLA SOX3A_XENLA ------------------------------------------------------------ SOX3_XENTR SOX3_XENTR ------------------------------------------------------------ B6VFL0_BOMOR B6VFL0_BOMOR ------------------------------------------------------------ A7VKI3_RANRU A7VKI3_RANRU ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5FZN8_BRABE Q5FZN8_BRABE --------------MFTNMMMHP------------------------------------- Q9NB28_BRAFL Q9NB28_BRAFL --------------MSTNMMMHQ------------------------------------- Q86SB8_HALRO Q86SB8_HALRO -------------------MQTDLKPIYSTSSQIS-----------------PINSQMHH Q4S778_TETNG Q4S778_TETNG ------------------------------------------------------------ Q0Q579_BRAFL Q0Q579_BRAFL ------------------MMETAVHPAQPSQPPSAS----------------------SP SX19A_DANRE SX19A_DANRE --------------MYS-MLEHDMKSAVPPTHQSA------------------QGMTQLN SX19B_DANRE SX19B_DANRE --------------MYS-MMEHELKTAG--PPHTL---------------QHSPGMSPPG Q6I753_CYNPY Q6I753_CYNPY --------------MYSMMMETDLHSPGAQPPANT------------------------- O57401_CHICK O57401_CHICK --------------MYSMMMETDLHSPGGAPAPGG-------------------GLSGQS SOX1_MOUSE SOX1_MOUSE --------------MYSMMMETDLHSPGGAQAPTN-------------------LSGPAG Q80XF2_MOUSE Q80XF2_MOUSE --------------MYSMMMETDLHSPGGAQAPTN-------------------LSGPAG SOX1_HUMAN SOX1_HUMAN --------------MYSMMMETDLHSPGGAQAPTN-------------------LSGPAG SOX1B_DANRE SOX1B_DANRE --------------MYSMMMETDLHSPG--AQTNT------------------------- Q4S0P5_TETNG Q4S0P5_TETNG --------------MYNMMMETDLHSPG--PQTNT------------------------- SOX1A_DANRE SOX1A_DANRE --------------MYSMMMETDLHSPG--PQTNT------------------------- SOX2_XENLA SOX2_XENLA --------------MYS-MMETELKPPA--PQQPS------------------------- SOX2_CHICK SOX2_CHICK --------------MYN-MMETELKPPA--PQQTS------------------------- B4YQU0_BUBBU B4YQU0_BUBBU ------------------------------------------------------------ B6VA41_HORSE B6VA41_HORSE --------------MYN-MMETELKPPG--PQQTSG----------------------GG SOX2_MOUSE SOX2_MOUSE --------------MYN-MMETELKPPG--PQQAS------------------------G B1Q0D1_PIG B1Q0D1_PIG --------------MYN-MMETELKPPG--PQQTS------------------------G Q3UES8_MOUSE Q3UES8_MOUSE ------------------------------------------------------------ Q3V2B6_MOUSE Q3V2B6_MOUSE ------------------------------------------------------------ Q60I23_MOUSE Q60I23_MOUSE --------------MYN-MMETELKPPG--PQQAS------------------------G B2R6J0_HUMAN B2R6J0_HUMAN --------------MYN-MMETELKPPG--PQQTS------------------------- A2VDX8_BOVIN A2VDX8_BOVIN --------------MYN-MMETELKPPG--PQQTS-----------------------GG B8XIA2_MACMU B8XIA2_MACMU --------------MYN-MMETELKPPG--PQQTS------------------------G SOX2_HUMAN SOX2_HUMAN --------------MYN-MMETELKPPG--PQQTS------------------------- SOX2_SHEEP SOX2_SHEEP --------------MYN-MMETELKPPG--PQQTS-----------------------GG B1PXF9_PIG B1PXF9_PIG --------------MYN-MMETELKPPG--PQQTS------------------------G Q38Q18_PIG Q38Q18_PIG ------------------------------------------------------------ Q08G14_ACISC Q08G14_ACISC --------------MYS-MMETELKPPA--PQPHS------------------------- B5X176_SALSA B5X176_SALSA --------------MYN-MMETELKPPA--PQTNS------------------------- B5LEE1_9TELE B5LEE1_9TELE ------------------------------------------------------------ SOX2_DANRE SOX2_DANRE --------------MYN-MMETELKPPA--PQPNT------------------------- Q09HM9_GADMO Q09HM9_GADMO ------------------------------------------------------------ A4GU07_OREMO A4GU07_OREMO ------------------------------------------------------------ Q4T665_TETNG Q4T665_TETNG --------------MYN-MMETELKPPA--PQTNT------------------------- B7U506_EPICO B7U506_EPICO --------------MYN-MMETELKPPA--PQTNT------------------------- A4GU04_ORENI A4GU04_ORENI ------------------------------PQTNT------------------------- A4GU05_OREAU A4GU05_OREAU ------------------------------PQTNT------------------------- A4GU06_9CICH A4GU06_9CICH ------------------------------------------------------------ Q28848_SMIMA Q28848_SMIMA --------------MYS-LLESEMKSPVVQGPPAG--------------AGGAAAPGGTG SOX3_HUMAN SOX3_HUMAN SPPATLAHLLPAPAMYS-LLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAAGGANSG SOX3_MOUSE SOX3_MOUSE --------------MYS-LLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAG Q6P564_MOUSE Q6P564_MOUSE SPPATLAHLLPAPAMYS-LLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAG Q5RKW0_MOUSE Q5RKW0_MOUSE SPPATLAHLLPAPAMYS-LLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAG Q4VBD8_MOUSE Q4VBD8_MOUSE SPPATLAHLLPAPAMYS-LLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAG A2AM37_MOUSE A2AM37_MOUSE SPPATLAHLLPAPAMYS-LLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAG Q80XF1_MOUSE Q80XF1_MOUSE --------------MYS-LLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAG B7T0X1_RAT B7T0X1_RAT ------------------------------------------------------------ Q4RP71_TETNG Q4RP71_TETNG -------------------METEIKTPL--PQSNS------------------------- A5Z1E1_ACASC A5Z1E1_ACASC --------------MYS-MMETEIKTPL--PQ--S------------------------- Q9PT76_ORYLA Q9PT76_ORYLA --------------MYN-MMETEIKTPL--PQSNS------------------------- Q06B63_LATCA Q06B63_LATCA --------------MYN-MMETEIKTPL--PQSNS------------------------- Q38KZ5_EPICO Q38KZ5_EPICO --------------MYN-MMETELKTPL--PQSNS------------------------- B5LSX2_9LABR B5LSX2_9LABR --------------MYN-MMETEIKTPL--PQSNS------------------------- A2I8A8_CARAU A2I8A8_CARAU --------------MYS-MMETEIKSPL--PQSN-------------------------- A9JSZ3_DANRE A9JSZ3_DANRE --------------MYN-MMETEIKSPI--PQSNT------------------------- SOX3_DANRE SOX3_DANRE --------------MYN-MMETEIKSPI--PQSNT------------------------- SOX3_CHICK SOX3_CHICK --------------MYS-MLETEIKTPQ--PTRAA---------------------RGEP Q2F7Y8_TAEGU Q2F7Y8_TAEGU ------------------------------------------------------------ Q9PSV6_CHICK Q9PSV6_CHICK --------------MYS-MLETEIKTPQPTPGSAG----------------------GNP SOX3B_XENLA SOX3B_XENLA --------------MYS-MLDTDMKSPV--QQSNA------------------------- SOX3A_XENLA SOX3A_XENLA --------------MYS-MLDTDIKSPV--QQSNA------------------------- SOX3_XENTR SOX3_XENTR --------------MYS-MLDTDLKSPV--QQSNA------------------------- B6VFL0_BOMOR B6VFL0_BOMOR ------------------------------------------------------------ A7VKI3_RANRU A7VKI3_RANRU --------------MYS-MLDTDIKSPV--QQASA------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5FZN8_BRABE Q5FZN8_BRABE ------------EKKEDEAAKR-DHVKRPMNAFMVWSRIQRRRIAEDSPKMHSSEISRRL Q9NB28_BRAFL Q9NB28_BRAFL ------------ERKEDEAAKK-DHVKRPMNAFMVWSRIQRRKIAEDNPKMHNSEISRRL Q86SB8_HALRO Q86SB8_HALRO MSGIQQQVVGS-VSAGSKSSQE-QRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q4S778_TETNG Q4S778_TETNG ----------ARGGKWLKRTLK-CTTRRSASA---WAR---------------------- Q0Q579_BRAFL Q0Q579_BRAFL TELKPPTSGAV-SPGNKAANDS-SRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SX19A_DANRE SX19A_DANRE GGVTHGSAKPAVNSQQQQSSDPMDKVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SX19B_DANRE SX19B_DANRE SGVGNAHHVSK-TACPPGVDPM-DKVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q6I753_CYNPY Q6I753_CYNPY --GQSGVGGGG-GGAGGAKANQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL O57401_CHICK O57401_CHICK GAGGGGGG----GGGGGGKAGQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX1_MOUSE SOX1_MOUSE ARGGGGGGGGG-GGGGGTKANQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q80XF2_MOUSE Q80XF2_MOUSE AGGGGGGGGGG-GGGGGTKANQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX1_HUMAN SOX1_HUMAN AGGGGGGGGGG-GGGGGAKANQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX1B_DANRE SOX1B_DANRE ------NTGHT-GPNSGSKVNQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q4S0P5_TETNG Q4S0P5_TETNG ------NTGQT-GPNSGSKANQ-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX1A_DANRE SOX1A_DANRE ------NPGQT-GPNSGSKANQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX2_XENLA SOX2_XENLA --GGNSNS----ASNNQNKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX2_CHICK SOX2_CHICK -GGGTGNSN---SAANNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B4YQU0_BUBBU B4YQU0_BUBBU --------------------------------------------------------SSRL B6VA41_HORSE B6VA41_HORSE GGGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX2_MOUSE SOX2_MOUSE GGGGGGNATAA-ATGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B1Q0D1_PIG B1Q0D1_PIG GGGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISRRL Q3UES8_MOUSE Q3UES8_MOUSE ------------------------------------------------------------ Q3V2B6_MOUSE Q3V2B6_MOUSE ----------------------------------VWSRGQRRKMAQENPKMHNSEISKRL Q60I23_MOUSE Q60I23_MOUSE GGGGGGNATAA-ATGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B2R6J0_HUMAN B2R6J0_HUMAN -GGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQGRKMAQENPKMHNSEISKRL A2VDX8_BOVIN A2VDX8_BOVIN GGGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B8XIA2_MACMU B8XIA2_MACMU GGGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX2_HUMAN SOX2_HUMAN -GGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX2_SHEEP SOX2_SHEEP GGGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B1PXF9_PIG B1PXF9_PIG GGGGGGNSTAA-AAGGNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q38Q18_PIG Q38Q18_PIG -----------------------------------------------------------L Q08G14_ACISC Q08G14_ACISC --GGTGNSN---SNANNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B5X176_SALSA B5X176_SALSA --GGTGNSN---SSGNNQKNSP-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B5LEE1_9TELE B5LEE1_9TELE --------------------------------FMVWSRGERRKMAQENPKMHNSEISKRL SOX2_DANRE SOX2_DANRE --GGTGNTN---SSGNNQKNSP-DRIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q09HM9_GADMO Q09HM9_GADMO ------------------------------------------------------------ A4GU07_OREMO A4GU07_OREMO ----------C-TLGDN----------------------------------------KRL Q4T665_TETNG Q4T665_TETNG --GGTGNTNTS-GTGGNQKNSP-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B7U506_EPICO B7U506_EPICO --GGSGNTNTS-GTGPNQKNSP-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL A4GU04_ORENI A4GU04_ORENI --GGTGNTNTS-GTGNNQKNSP-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL A4GU05_OREAU A4GU05_OREAU --GGTGNTNTS-GTGNNQKNSP-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL A4GU06_9CICH A4GU06_9CICH ------------------------------------------------PKMHNSEISKRL Q28848_SMIMA Q28848_SMIMA KSGANAGGGGG-GAGGGGGGDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL SOX3_HUMAN SOX3_HUMAN GGSSGG------ASGGGGGTDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL SOX3_MOUSE SOX3_MOUSE NGGSGGANGGG-GGGGGGGSDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL Q6P564_MOUSE Q6P564_MOUSE NGGSGGANGGG-GGGGGGGSDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL Q5RKW0_MOUSE Q5RKW0_MOUSE NGGSGGANGGG-GGGGGGGSDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL Q4VBD8_MOUSE Q4VBD8_MOUSE NGGSGGANGGG-GGGGGGGSDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL A2AM37_MOUSE A2AM37_MOUSE NGGSGGANGGG-GGGGGGGSDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL Q80XF1_MOUSE Q80XF1_MOUSE NGGSGGANGGG-GGGGGGGSDQ-DRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRL B7T0X1_RAT B7T0X1_RAT ------------------------------------------------------------ Q4RP71_TETNG Q4RP71_TETNG --GSA-------PGGKNNSSNE-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL A5Z1E1_ACASC A5Z1E1_ACASC --GSAQ------GAKNNSVSDQ-ERVKRPMNAFMVWSRGQRRKMAQENTKMHNSEISKRL Q9PT76_ORYLA Q9PT76_ORYLA --GSAA------GAKNNSANDQ-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q06B63_LATCA Q06B63_LATCA --GSAP------GAKNNSASDQ-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q38KZ5_EPICO Q38KZ5_EPICO --GSAP------GAKNNSASDQ-EHVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B5LSX2_9LABR B5LSX2_9LABR --GSAP------GAKNNSASDQ-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL A2I8A8_CARAU A2I8A8_CARAU --------SVA-GGKNNSSNDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL A9JSZ3_DANRE A9JSZ3_DANRE --GSVT------GGKNNSANDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX3_DANRE SOX3_DANRE -------GSVT-GGKNNSANDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX3_CHICK SOX3_CHICK ARAATAKVGGA-AAADGCRSDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL Q2F7Y8_TAEGU Q2F7Y8_TAEGU --------------------------------------------HQENPKMHNSEISKRL Q9PSV6_CHICK Q9PSV6_CHICK APGGNGKGGGGAGSGAGAGSDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX3B_XENLA SOX3B_XENLA --LSGGPGTPG-GKGNTSTPDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX3A_XENLA SOX3A_XENLA --PIGGPATPG-GKGNASTLDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL SOX3_XENTR SOX3_XENTR --PNGGPGTPG-GKGNASIPDQ-ERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL B6VFL0_BOMOR B6VFL0_BOMOR ----------------------------PMNAFMVWSRGQRRKMAQENPKMHNSEISKRL A7VKI3_RANRU A7VKI3_RANRU --QSGGAVTPG-AKGNAANQDQ-DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRL MATCH CONSENSUS ?????????????????????????VKRPMNAFMVWSRGQRRKMA?ENPKMHNSEISKRL

Q5FZN8_BRABE Q5FZN8_BRABE GEMWRELPAEERRPFVDESRRLRAEHMEKYPDCKCRPRRKLKTMMKNS----SFPTMPGG Q9NB28_BRAFL Q9NB28_BRAFL GEMWKELSAEEKKPFVEESKRLRAEHMEKYPDYKYRPRRKLKTMMKNS----SFPTMPGG Q86SB8_HALRO Q86SB8_HALRO GAEWKLLSEGDKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK-MMKKD----KY----GS Q4S778_TETNG Q4S778_TETNG --EWKVMTEVEKRPFIDEAKGLRAMHMKEHPDYKYRPRRIDQDAAEKG----Q--VLPGG Q0Q579_BRAFL Q0Q579_BRAFL GAEWKLLTEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-SLPGG SX19A_DANRE SX19A_DANRE GAEWKLLTDAEKRPFIDEAKRLRALHMKEYPDYKYKPRRKTKPVLKKDNPAAKY-PLSAG SX19B_DANRE SX19B_DANRE GAEWKLLTDVEKRPFIDEAKRLRAVHMKEYPDYKYKPRRKTKALMKKDNPVGKY-PLAAG Q6I753_CYNPY Q6I753_CYNPY GAEWKVMSEGEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKD----KY-SLAGG O57401_CHICK O57401_CHICK GAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKD----KY-SLAGG SOX1_MOUSE SOX1_MOUSE GAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKD----KY-SLAGG Q80XF2_MOUSE Q80XF2_MOUSE GAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKD----KY-SLAGG SOX1_HUMAN SOX1_HUMAN GAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKD----KY-SLAGG SOX1B_DANRE SOX1B_DANRE GAEWKLMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLAGG Q4S0P5_TETNG Q4S0P5_TETNG GAEWKLMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKSLLKKD----KY-SLAGG SOX1A_DANRE SOX1A_DANRE GAEWKVMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLAGG SOX2_XENLA SOX2_XENLA GAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG SOX2_CHICK SOX2_CHICK GAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B4YQU0_BUBBU B4YQU0_BUBBU ----------------SRGKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B6VA41_HORSE B6VA41_HORSE GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKX----XX-XXXGG SOX2_MOUSE SOX2_MOUSE GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B1Q0D1_PIG B1Q0D1_PIG GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q3UES8_MOUSE Q3UES8_MOUSE ------------RPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q3V2B6_MOUSE Q3V2B6_MOUSE GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q60I23_MOUSE Q60I23_MOUSE GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B2R6J0_HUMAN B2R6J0_HUMAN GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG A2VDX8_BOVIN A2VDX8_BOVIN GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B8XIA2_MACMU B8XIA2_MACMU GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG SOX2_HUMAN SOX2_HUMAN GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG SOX2_SHEEP SOX2_SHEEP GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B1PXF9_PIG B1PXF9_PIG GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q38Q18_PIG Q38Q18_PIG GAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q08G14_ACISC Q08G14_ACISC GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B5X176_SALSA B5X176_SALSA GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B5LEE1_9TELE B5LEE1_9TELE GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG SOX2_DANRE SOX2_DANRE GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q09HM9_GADMO Q09HM9_GADMO --------------------------MKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG A4GU07_OREMO A4GU07_OREMO GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q4T665_TETNG Q4T665_TETNG GAEWKLLSENEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG B7U506_EPICO B7U506_EPICO GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG A4GU04_ORENI A4GU04_ORENI GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG A4GU05_OREAU A4GU05_OREAU GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG A4GU06_9CICH A4GU06_9CICH GAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKD----KY-TLPGG Q28848_SMIMA Q28848_SMIMA GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGN SOX3_HUMAN SOX3_HUMAN GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPSG SOX3_MOUSE SOX3_MOUSE GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGG Q6P564_MOUSE Q6P564_MOUSE GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGG Q5RKW0_MOUSE Q5RKW0_MOUSE GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGG Q4VBD8_MOUSE Q4VBD8_MOUSE GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGG A2AM37_MOUSE A2AM37_MOUSE GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGG Q80XF1_MOUSE Q80XF1_MOUSE GADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGG B7T0X1_RAT B7T0X1_RAT ---------------------------------------KTKTLLKKD----KY-SLPGG Q4RP71_TETNG Q4RP71_TETNG GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG A5Z1E1_ACASC A5Z1E1_ACASC GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG Q9PT76_ORYLA Q9PT76_ORYLA GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG Q06B63_LATCA Q06B63_LATCA GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG Q38KZ5_EPICO Q38KZ5_EPICO GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG B5LSX2_9LABR B5LSX2_9LABR GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----RY-SLPGG A2I8A8_CARAU A2I8A8_CARAU GADWKILTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG A9JSZ3_DANRE A9JSZ3_DANRE GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG SOX3_DANRE SOX3_DANRE GADWKLLTDAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKD----KY-SLPGG SOX3_CHICK SOX3_CHICK GADWKLLSDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGN Q2F7Y8_TAEGU Q2F7Y8_TAEGU GADWKLLSDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGN Q9PSV6_CHICK Q9PSV6_CHICK GADWKLLSDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGN SOX3B_XENLA SOX3B_XENLA GADWKLLSDSEKRPFIDEAKRLRAVHMKDYPDYKYRPRRKTKTLLKKD----KY-SLPGN SOX3A_XENLA SOX3A_XENLA GADWKLLSDSDKRPFIDEAKRLRAVHMKDYPDYKYRPRRKTKTLLKKD----KY-SLPGN SOX3_XENTR SOX3_XENTR GADWKLLSDSEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGN B6VFL0_BOMOR B6VFL0_BOMOR GADWKLLSDAEKRPFIDEAKRLRAVHMKDYPDYKYRPRRKTKTLLKKD----KY-SLPGN A7VKI3_RANRU A7VKI3_RANRU GADWKLLSDSEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKD----KY-SLPGN MATCH : :: .. CONSENSUS GA?WK?L???EKRPFIDEAKRLRA?HMKE?PDYKYRPRRKTKTL?KKD????KY??LPGG

Q5FZN8_BRABE Q5FZN8_BRABE -MPPNYFP-ASNCSPP------------PALPMSMTE----------QY-SHMNGYM--G Q9NB28_BRAFL Q9NB28_BRAFL -MPPNYFP-ASNCSPP------------PALQMSMPE----------QY-GHMNGYMS-G Q86SB8_HALRO Q86SB8_HALRO -TIL---P-------SSTSSAVATSIGRSPLPNSLD------------Y-QHLNGY---G Q4S778_TETNG Q4S778_TETNG -RAP-GLP-RGHGRRA--AVGQSGWRPRGRTRERMGE---------------RRVLGSGG Q0Q579_BRAFL Q0Q579_BRAFL -LIA---A-NGAPVQRTIATG-------------MDQ-----------Y-AHMNGYMSNN SX19A_DANRE SX19A_DANRE -NLL---A-AAAAQGS-------------GGSPRMDS-----------Y-----GWGHTG SX19B_DANRE SX19B_DANRE NLLA---S----------AVAQG-----QGGSPRMDG-----------Y-----GWGHAG Q6I753_CYNPY Q6I753_CYNPY -LLS---A-GGGP----GGMGVG-LSP-GGVGQRLESPGG-GGAGGGGY-AHMNGWAN-G O57401_CHICK O57401_CHICK -LLG---AGPAAGGPPAVGVGMGVGVIPGGVGQRLES---PGGAAGGGY-AHMNGWAN-G SOX1_MOUSE SOX1_MOUSE -LLA---A-GAGGGGAAVAMGVGVGVGAAAVGQRLES---PGGAAGGGY-AHVNGWAN-G Q80XF2_MOUSE Q80XF2_MOUSE -LLA---A-GAGGGGAAVAMGVGVGVGAAAVGQRLES---PGGAAGGGY-AHVNGWAN-G SOX1_HUMAN SOX1_HUMAN -LLA---A-GAGGGGAAVAMGVGVGVGAAAVGQRLES---PGGAAGGGY-AHVNGWAN-G SOX1B_DANRE SOX1B_DANRE -LLA-----GSGG-----GGGVGLGMGAAGVGQRLESPVGHGGSTAASY-AHMNGWTN-G Q4S0P5_TETNG Q4S0P5_TETNG -LLS-----GPSGGG---GVGLGVGMNSSGVGQRLESPGGHGGSAGTGY-AHMNGWAN-G SOX1A_DANRE SOX1A_DANRE -LL------G--------GAGGGVGMSPAGVGQRLESPGGHGGSASAGY-AHMNGWAN-G SOX2_XENLA SOX2_XENLA -LLA---P-GANAMTS----GVGGSLG-AGVNQRMDT-----------Y-AHMNGWTN-G SOX2_CHICK SOX2_CHICK -LLA---P-GTNTMTT--GVGVGATLG-AGVNQRMDS-----------Y-AHMNGWTN-G B4YQU0_BUBBU B4YQU0_BUBBU -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G B6VA41_HORSE B6VA41_HORSE -LLA---A-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G SOX2_MOUSE SOX2_MOUSE -LLA---P-GGNSMAS--GVGVGAGLG-GGLNQRMDS-----------Y-AHMNGWSN-G B1Q0D1_PIG B1Q0D1_PIG -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-C Q3UES8_MOUSE Q3UES8_MOUSE -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G Q3V2B6_MOUSE Q3V2B6_MOUSE -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G Q60I23_MOUSE Q60I23_MOUSE -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G B2R6J0_HUMAN B2R6J0_HUMAN -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G A2VDX8_BOVIN A2VDX8_BOVIN -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G B8XIA2_MACMU B8XIA2_MACMU -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G SOX2_HUMAN SOX2_HUMAN -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G SOX2_SHEEP SOX2_SHEEP -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G B1PXF9_PIG B1PXF9_PIG -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G Q38Q18_PIG Q38Q18_PIG -LLA---P-GGNSMAS--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWSN-G Q08G14_ACISC Q08G14_ACISC -LLA---P-GGNAMNS--GVGVGAGMG-AGVNQRMDS-----------Y-AHMNGWAN-G B5X176_SALSA B5X176_SALSA -LLA---P-GGNGMGA--GVGVGGGLG-GGVNQRMDS-----------Y-AHMNGWTN-G B5LEE1_9TELE B5LEE1_9TELE -LLA---P-GGDAIGA--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWTN-G SOX2_DANRE SOX2_DANRE -LLA---P-GGNGMGA--GVGVGAGLG-AGVNQRMDS-----------Y-AHMNGWTN-G Q09HM9_GADMO Q09HM9_GADMO -LLA---P-GGNGMGGGVGVGVGGGLG-GGVNQRMDS-----------YAAHMNGWTN-A A4GU07_OREMO A4GU07_OREMO -LLA---P-GGNGMGTGVGVGVGAGLG-GGVNQRMDS-----------YAAHMNGWTN-G Q4T665_TETNG Q4T665_TETNG -LLA---P-GGNGMGAGVGVGVGAGLG-GGVNQRMDS-----------YAAHMNGWSN-G B7U506_EPICO B7U506_EPICO -LLA---P-GGNGMGAGVGVGVGSGLG-GGVNQRMDS-----------YAAHMNGWTN-G A4GU04_ORENI A4GU04_ORENI -LLA---P-GGNGMGTGVGVGVGAGLG-GGVNQRMDS-----------YAAHMNGWTN-G A4GU05_OREAU A4GU05_OREAU -LLA---P-GGNGMGTGVGVGVGAGLG-GGVNQRMDS-----------YAAHMNGWTN-G A4GU06_9CICH A4GU06_9CICH -LLA---P-GGNGMGTGVGVGVGAGLG-GGVNQRMDS-----------YAAHMNGWTN-G Q28848_SMIMA Q28848_SMIMA -LLP---P-GTAAVNS--PVGVG---------QRLDT-----------Y-AHMNGWAN-G SOX3_HUMAN SOX3_HUMAN -LLP---P-GAAAAAAAAAAAAAAASSPVGVGQRLDT-----------Y-THVNGWAN-G SOX3_MOUSE SOX3_MOUSE -LPP---P-GAAAAAAAAAAAAAASSP-VGVGQRLDT-----------Y-THVNGWAN-G Q6P564_MOUSE Q6P564_MOUSE -LLP---P-GAAAAAAAAAAAAAASSP-VGVGQRLDT-----------Y-THVNGWAN-G Q5RKW0_MOUSE Q5RKW0_MOUSE -LLP---P-GAAAAAAAAAAAAAASSP-VGVGQRLDT-----------Y-THVNGWAN-G Q4VBD8_MOUSE Q4VBD8_MOUSE -LLP---P-GAAAAAAAAAAAAAASSP-VGVGQRLDT-----------Y-THVNGWAN-G A2AM37_MOUSE A2AM37_MOUSE -LLP---P-GAAAAAAAAAAAAAASSP-VGVGQRLDT-----------Y-THVNGWAN-G Q80XF1_MOUSE Q80XF1_MOUSE -LLP---P-GAAAAAAAAAAAAAASSP-VGVGQRLDT-----------Y-THVNGWAN-G B7T0X1_RAT B7T0X1_RAT -LLP---P-GAAAAAAAAAAAAAASSP-VGVGQRLDT-----------Y-THVNGWAN-G Q4RP71_TETNG Q4RP71_TETNG -LLT---P-GANPVNN--SVSVG---------QRMDG-----------Y-AHMNGWTN-S A5Z1E1_ACASC A5Z1E1_ACASC -LLA---P-GANAVNN--SVSVG---------QRMDG-----------Y-AHMNGWTN-S Q9PT76_ORYLA Q9PT76_ORYLA -LLA---P-GANAVNN--SVSVG---------QRMDG-----------Y-AHMNGWTN-S Q06B63_LATCA Q06B63_LATCA -LLP---P-GANAVNN--SVSVG---------QRMDG-----------Y-AHMNGWTN-S Q38KZ5_EPICO Q38KZ5_EPICO -LLA---P-GANAVNN--SVSVG---------QRMDG-----------Y-AHMNGWTN-S B5LSX2_9LABR B5LSX2_9LABR -LLA---P-GASAVNN--SVSVG---------QRMDG-----------Y-AHMNGWSN-S A2I8A8_CARAU A2I8A8_CARAU -LLA---P-GATAVNS--AVSVG---------QRMD------------Y-THMNGWTN-S A9JSZ3_DANRE A9JSZ3_DANRE -LLA---P-GANAVNN--AVSVG---------QRMD------------Y-THMNGWTN-S SOX3_DANRE SOX3_DANRE -LLA---P-GANAVNN--AVSVG---------QRMD------------Y-THMNGWTN-S SOX3_CHICK SOX3_CHICK -LWP---P-GSAGAAA------------VGVGQRIDT-----------Y-AHMNGWTN-G Q2F7Y8_TAEGU Q2F7Y8_TAEGU -LLA---PGGGNAVSS--PVGVG---------QRIDT-----------Y-AHMNGWTN-G Q9PSV6_CHICK Q9PSV6_CHICK -LLA---PGGGNAVSS--PVGVG---------QRIDT-----------Y-AHMNGWTN-G SOX3B_XENLA SOX3B_XENLA -LLA---P-GINPVSG----GVG---------QRIDT-----------Y-PHMNGWTN-G SOX3A_XENLA SOX3A_XENLA -LLA---P-GVSPVAS--SVGVG---------QRIDT-----------Y-AHMNGWTN-G SOX3_XENTR SOX3_XENTR -LLA---P-GVSPVAS--SVGVG---------QRIDT-----------Y-AHMNGWTN-G B6VFL0_BOMOR B6VFL0_BOMOR -LLA---P-GVSPVGS--TVGVG---------QRIDT-----------Y-AHMNGWTN-G A7VKI3_RANRU A7VKI3_RANRU -LLA---P-GVSPVSS--TVGVG---------QRIDT-----------Y-AHMNGWTN-G MATCH : CONSENSUS ?LL????P?G??????????????????????QR?D????????????Y??H?NGW?N?G

Q5FZN8_BRABE Q5FZN8_BRABE GYH---------SSMMRD-P--GNRTVTSR-----SSRR-----LLRRRRPGACHQVRHG Q9NB28_BRAFL Q9NB28_BRAFL YHS----------SMMRDPGN-PY-SHQVI-----PSSA----------AATTAGSMPT- Q86SB8_HALRO Q86SB8_HALRO PYS-----------TMIP-QD-PY-STQGY-----GVPG----------NQSAVGHLTQ- Q4S778_TETNG Q4S778_TETNG GRR------RAAHAMMQEAHW-AYTQPPAH-----HPHH-----------HPHHHPQ-H- Q0Q579_BRAFL Q0Q579_BRAFL AYT----------HMMHQDQLHAYP-HPGI-----SPAQ----------TASQMASNASL SX19A_DANRE SX19A_DANRE GYP-----------GMQTDAL-GYSQ-----------------------------QL-H- SX19B_DANRE SX19B_DANRE GYM-----------GMQGDAL-GYPQ-----------------------------QL-H- Q6I753_CYNPY Q6I753_CYNPY GYPGSVAAAAAAA-MMQEAQL-AYSQQQQQ-----HHHP--HHPHHAHHHPHQPQPM-H- O57401_CHICK O57401_CHICK AYPGSVAAAAAAAAMMQEAQL-AYGQHPGGGGHPHHPHPHHPHH------PHNPQPM-H- SOX1_MOUSE SOX1_MOUSE AYPGSVAAAAAAAAMMQEAQL-AYGQHPGAGGRHPHAHPAHPHPHHPHAHPHNPQPM-H- Q80XF2_MOUSE Q80XF2_MOUSE AYPGSVAAAAAAAAMMQEAQL-AYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPM-H- SOX1_HUMAN SOX1_HUMAN AYPGSVAAAAAAAAMMQEAQL-AYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPM-H- SOX1B_DANRE SOX1B_DANRE AYSGQVAAAAAAAAMMQEAQL-AYGQHPGS-----GAHHHHGHHH----HPHNPQPM-H- Q4S0P5_TETNG Q4S0P5_TETNG AYSGQVAAAAAAAAMMQEAQL-AYSQHPGS-----AAHHHHSHHH----HTHNPQPM-H- SOX1A_DANRE SOX1A_DANRE TYSGQVAAAAAAAAMMQEAQL-AYSQHPGS-----GSHHHHAHHH----HPHNPQPM-H- SOX2_XENLA SOX2_XENLA GYG-----------MMQE-QL-GYPQHPGL-----NAHN-----------APQMQPM-H- SOX2_CHICK SOX2_CHICK GYG-----------MMQE-QL-GYPQHPGL-----NAHN-----------AAQMQPM-H- B4YQU0_BUBBU B4YQU0_BUBBU SYS-----------MMQD-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- B6VA41_HORSE B6VA41_HORSE SYS-----------MMQD-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- SOX2_MOUSE SOX2_MOUSE SYS-----------MMQE-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- B1Q0D1_PIG B1Q0D1_PIG SYS-----------MMQD-QL-GYPQHPGL-----NAHS-----------AAQMQPM-H- Q3UES8_MOUSE Q3UES8_MOUSE SYS-----------MMQE-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- Q3V2B6_MOUSE Q3V2B6_MOUSE SYS-----------MMQE-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- Q60I23_MOUSE Q60I23_MOUSE SYS-----------MMQE-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- B2R6J0_HUMAN B2R6J0_HUMAN SYS-----------MMQD-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- A2VDX8_BOVIN A2VDX8_BOVIN SYS-----------MMQD-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- B8XIA2_MACMU B8XIA2_MACMU SYS-----------MMQD-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- SOX2_HUMAN SOX2_HUMAN SYS-----------MMQD-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- SOX2_SHEEP SOX2_SHEEP SYS-----------MMQD-QL-GYPQHPGL-----NAHG-----------AAQMQPM-H- B1PXF9_PIG B1PXF9_PIG SYS-----------MMQD-QL-GYPQHPGL-----NAHS-----------AAQMQPM-H- Q38Q18_PIG Q38Q18_PIG SYS-----------MMQD-QL-GYPQHPGL-----NAHS-----------AAQMQPM-H- Q08G14_ACISC Q08G14_ACISC GYG-----------MMQE-QL-GYPQHPGL-----NAHS-----------AAQMQPM-H- B5X176_SALSA B5X176_SALSA GYG-----------MMQE-QL-GYGQHPGL-----NAHN-----------NAQMQQM-H- B5LEE1_9TELE B5LEE1_9TELE GYG-----------MMQE-QL-GYPQHPGL-----NAHN-----------TAQMQPM-H- SOX2_DANRE SOX2_DANRE GYG-----------MMQE-QL-GYPQHPSL-----NAHN-----------TAQMQPM-H- Q09HM9_GADMO Q09HM9_GADMO GYG-----------MMQE-QL-SY-QHPGL-----NAHN-----------AGQMQSM-H- A4GU07_OREMO A4GU07_OREMO GYG-----------MMQD-QL-GY-QHPGL-----NAHN-----------PSQMQSM-H- Q4T665_TETNG Q4T665_TETNG GYG-----------MMQD-QL-SY-QHPGL-----NAHN-----------PGQMQSM-H- B7U506_EPICO B7U506_EPICO GYG-----------MMQD-QL-SY-QHPGL-----NAHN-----------PSQMQSM-H- A4GU04_ORENI A4GU04_ORENI GYG-----------MMQD-QL-GY-QHPGL-----NAHN-----------PSQMQSM-H- A4GU05_OREAU A4GU05_OREAU GYG-----------MMQD-QL-GY-QHPGL-----NAHN-----------PSQMQSM-H- A4GU06_9CICH A4GU06_9CICH GYG-----------MMQD-QL-GY-QHPGL-----NAHN-----------PSQMQSM-H- Q28848_SMIMA Q28848_SMIMA AYS-----------LMPE-QL-SYGQHPGM-----N--------------GPQLQQM-H- SOX3_HUMAN SOX3_HUMAN AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPPM-H- SOX3_MOUSE SOX3_MOUSE AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPQM-H- Q6P564_MOUSE Q6P564_MOUSE AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPQM-H- Q5RKW0_MOUSE Q5RKW0_MOUSE AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPQM-H- Q4VBD8_MOUSE Q4VBD8_MOUSE AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPQM-H- A2AM37_MOUSE A2AM37_MOUSE AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPQM-H- Q80XF1_MOUSE Q80XF1_MOUSE AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPQM-H- B7T0X1_RAT B7T0X1_RAT AYS-----------LVQE-QL-GYAQPPSM-----SSPP----------PPPALPQM-H- Q4RP71_TETNG Q4RP71_TETNG AYS-----------LMQD-QL-AYPQHHNM-----N--------------SPQIQQM-H- A5Z1E1_ACASC A5Z1E1_ACASC AYS-----------LMQD-QL-AYPQHHSM-----N--------------SPQIQQM-H- Q9PT76_ORYLA Q9PT76_ORYLA AYS-----------LMQD-QL-AYPQHPSM-----N--------------SPQIQQM-H- Q06B63_LATCA Q06B63_LATCA AYS-----------LMQD-QL-AYPQHHSM-----N--------------SPQIQQM-H- Q38KZ5_EPICO Q38KZ5_EPICO AYS-----------LMQD-QL-AYPQHHSM-----N--------------SPQIQQM-H- B5LSX2_9LABR B5LSX2_9LABR AYS-----------LMQD-QL-AYPQHHSM-----N--------------SPQIQQM-H- A2I8A8_CARAU A2I8A8_CARAU AYS-----------LMQD-QL-AYPQHPSM-----N--------------SSQLQQM-H- A9JSZ3_DANRE A9JSZ3_DANRE AYS-----------LMQD-QL-AYPQHPSM-----N--------------SPQIQQM-H- SOX3_DANRE SOX3_DANRE AYS-----------LMQD-QL-AYPQHPSM-----N--------------SPQIQQM-H- SOX3_CHICK SOX3_CHICK AYS-----------LMQD-QL-GYGQHPGM-----N--------------SPQLQQM-H- Q2F7Y8_TAEGU Q2F7Y8_TAEGU AYS-----------LMQE-QL-GYSQHPGM-----N--------------SPQLQQM-H- Q9PSV6_CHICK Q9PSV6_CHICK AYS-----------LMQD-QL-GYGQHPGM-----N--------------SPQLQQM-H- SOX3B_XENLA SOX3B_XENLA AYS-----------LMQE-QL-GYGQHPAM-----N--------------SSQMQQIQH- SOX3A_XENLA SOX3A_XENLA AYS-----------LMQD-QL-GYSQHPAM-----N--------------SPQMQQIQH- SOX3_XENTR SOX3_XENTR AYS-----------LMQD-QL-GYSQHPGM-----N--------------SPQMQQIQH- B6VFL0_BOMOR B6VFL0_BOMOR AYS-----------LMQD-QL-GYSQHPGM-----N--------------SPQIQQM-H- A7VKI3_RANRU A7VKI3_RANRU AYS-----------LMQD-QL-GYSQHPGM-----N--------------SPQIQQM-H- MATCH : CONSENSUS ?Y?????????????MQ??QL??Y?Q?P????????????????????????????M?H?

Q5FZN8_BRABE Q5FZN8_BRABE --RAHLQAPTRHAG-TTSKP--QQLR--SPT-------SP----------VSSNQGTD-- Q9NB28_BRAFL Q9NB28_BRAFL --RYDMAA-LTYS---------TYAS-MPPT---TSYTTS----------SCALQPYP-- Q86SB8_HALRO Q86SB8_HALRO --RYDMP--MYYPS-YTAAPTIPTMG-NPGVSHLGGYHGPPT--------SYSVGPPTLP Q4S778_TETNG Q4S778_TETNG --RYDMSA-LSYSP-IPNSQ--SYMSASPPG-----YGGLTGYT------HHQHQSSP-- Q0Q579_BRAFL Q0Q579_BRAFL PPRYDMSGQIPPYP-MATTN--SYSSYTSSS-----YTTN----------PYSHHYTT-- SX19A_DANRE SX19A_DANRE --RYDLSA-LQYPSAMATAQ--TYMN-GANS-----YNPM----------SYSSTPQQ-- SX19B_DANRE SX19B_DANRE --RYDLSA-LQYPA-AQ-----PYMN-SASS-----YSQM----------SYSSSPQQ-- Q6I753_CYNPY Q6I753_CYNPY --RYDMSA-LQYSP-LG-SQ--GYMSASPSG-----Y-AL----------SYSGGQGGGQ O57401_CHICK O57401_CHICK --RYDMGA-LQYSP-ISNSQ--GYVS-ASPS----GYGAL----------PYGSQPHQ-- SOX1_MOUSE SOX1_MOUSE --RYDMGA-LQYSP-ISNSQ--GYMS-ASPS----GYGGI----------PYGAAAAAAA Q80XF2_MOUSE Q80XF2_MOUSE --RYDMGA-LQYSP-ISNSQ--GYMS-ASPS----GYGGI----------PYGAAAAAAA SOX1_HUMAN SOX1_HUMAN --RYDMGA-LQYSP-ISNSQ--GYMS-ASPS----GYGGL----------PYGAAAAAAA SOX1B_DANRE SOX1B_DANRE --RYEMTA-LQYSP-LSNSQ--SYMS-ASPS----GYGGI----------SYTQHQNS-- Q4S0P5_TETNG Q4S0P5_TETNG --RYDMTA-LQYSP-ISNSQ--SYMN-ASPS----GYGGI----------SYTQHQGS-- SOX1A_DANRE SOX1A_DANRE --RYDMTA-LQYSP-ISNSQ--SYMS-ASPS----GYGGI----------SYTQHQNS-- SOX2_XENLA SOX2_XENLA --RYDVSA-LQYNS-MSSSQ--TYMN-GSPT-----Y-SM----------SYSQQGAP-- SOX2_CHICK SOX2_CHICK --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- B4YQU0_BUBBU B4YQU0_BUBBU --RYDVSA-LQYNS-MTDSQ---------------------------------------- B6VA41_HORSE B6VA41_HORSE --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- SOX2_MOUSE SOX2_MOUSE --RYVVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- B1Q0D1_PIG B1Q0D1_PIG --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- Q3UES8_MOUSE Q3UES8_MOUSE --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- Q3V2B6_MOUSE Q3V2B6_MOUSE --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- Q60I23_MOUSE Q60I23_MOUSE --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- B2R6J0_HUMAN B2R6J0_HUMAN --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- A2VDX8_BOVIN A2VDX8_BOVIN --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- B8XIA2_MACMU B8XIA2_MACMU --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- SOX2_HUMAN SOX2_HUMAN --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- SOX2_SHEEP SOX2_SHEEP --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- B1PXF9_PIG B1PXF9_PIG --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- Q38Q18_PIG Q38Q18_PIG --RYDVSA-LQYNS-MTSSQ--TYMN-GSPT-----Y-SM----------SYSQQGTP-- Q08G14_ACISC Q08G14_ACISC --RYDMSA-LQYNS-MTNSQ--TYMN-GSPT-----Y-SM----------SYSQQSTP-- B5X176_SALSA B5X176_SALSA --RYDMSA-LQYNS-MTNSQ--TYMN-GSPT-----Y-SM----------SYSQQSTP-- B5LEE1_9TELE B5LEE1_9TELE --RYDMSA-LQYNS-MTNSQ--TYMN-GSPT-----Y-SM----------SYSQQSTP-- SOX2_DANRE SOX2_DANRE --RYDMSA-LQYNS-MTNSQ--TYMN-GSPT-----Y-SM----------SYSQQSTP-- Q09HM9_GADMO Q09HM9_GADMO --RYDMSA-LQYNT-MSSSQ--SYMN-GSPT-----Y-SM----------SYAQQPTP-- A4GU07_OREMO A4GU07_OREMO --RYDMSA-LQYNS-MTSSQ--SYMN-GSPT-----Y-SM----------SYSQQTTP-- Q4T665_TETNG Q4T665_TETNG --RYDMSA-LQYNS-MTSSQ--SYMN-GSPT-----Y-SM----------SYSQQSTP-- B7U506_EPICO B7U506_EPICO --RYDMSA-LQYNT-MTSSQ--SYMN-GSPT-----Y-SM----------SYSQQTTP-- A4GU04_ORENI A4GU04_ORENI --RYDMSA-LQYNS-MTSSQ--SYMN-GSPT-----Y-SM----------SYSQQTTP-- A4GU05_OREAU A4GU05_OREAU --RYDMSA-LQYNS-MTSSQ--SYMN-GSPT-----Y-SM----------SYSQQTTP-- A4GU06_9CICH A4GU06_9CICH --RYDMSA-LQYNS-MTSSQ--SYMN-GSPT-----Y-SM----------SYSQQTTP-- Q28848_SMIMA Q28848_SMIMA --RYDMAG---------------------------------------------------- SOX3_HUMAN SOX3_HUMAN --RYDMAG-LQYSP-MMPPGAQSYMNVAAAAAAASGYGGMAPSATAAAAAAYGQQPAT-- SOX3_MOUSE SOX3_MOUSE --RYDMAG-LQYSP-MMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPAT-- Q6P564_MOUSE Q6P564_MOUSE --RYDMAG-LQYSP-MMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPAT-- Q5RKW0_MOUSE Q5RKW0_MOUSE --RYDMAG-LQYSP-MMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPAT-- Q4VBD8_MOUSE Q4VBD8_MOUSE --RYDMAG-LQYSP-MMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPAT-- A2AM37_MOUSE A2AM37_MOUSE --RYDMAG-LQYSP-MMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPAT-- Q80XF1_MOUSE Q80XF1_MOUSE --RYDMAG-LQYSP-MMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPAT-- B7T0X1_RAT B7T0X1_RAT --RYDMAG-LQYSP-MMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPAT-- Q4RP71_TETNG Q4RP71_TETNG --RYEMAG-LQYPM-MSSAQ--TYMN-AAST-----Y-SMSP--------AYTQQTSS-- A5Z1E1_ACASC A5Z1E1_ACASC --RYEMAG-LQYPM-MSSAQ--TYMN-AAST-----Y-SMSP--------AYTQQTGS-- Q9PT76_ORYLA Q9PT76_ORYLA --RYEMAG-LQYPM-MSSAQ--TYMN-AAST-----Y-SMSP--------AYTQQTGS-- Q06B63_LATCA Q06B63_LATCA --RYEMAG-LQYPM-MSSAQ--TYMN-AAST-----Y-SMSP--------AYTQQTTS-- Q38KZ5_EPICO Q38KZ5_EPICO --RYEMAG-LQYPM-MSSAQ--TYMN-AAST-----Y-SMSP--------AYTQQTTS-- B5LSX2_9LABR B5LSX2_9LABR --RYEMAG-LQYPM-MSSAQ--TYMN-AAST-----Y-SMSP--------AYTQQTSS-- A2I8A8_CARAU A2I8A8_CARAU --RYDMAG-LQYPM-MSTAQ--TYMN-AAST-----Y-SMSP--------AYTQQTSS-- A9JSZ3_DANRE A9JSZ3_DANRE --RYDMAG-LQYPM-MSTAQ--TYMN-AAST-----YSSMSP--------AYTQQTSS-- SOX3_DANRE SOX3_DANRE --RYDMAG-LQYPM-MSTAQ--TYMN-AAST-----YSSMSP--------AYTQQTSS-- SOX3_CHICK SOX3_CHICK --RYDMPG-LQYSP-MMSTAQ-TYMN-AGLH-----L-QHVP-------RPYGQQPST-- Q2F7Y8_TAEGU Q2F7Y8_TAEGU --RYDMPG-LQYSP-MMSTAQ-TYMN-AAST-----Y-SMSP-------AAYGQQPSS-- Q9PSV6_CHICK Q9PSV6_CHICK --RYDMPG-LQYSP-MMSTAQ-TYMN-AAST-----Y-SMSP-------AAYGQQPST-- SOX3B_XENLA SOX3B_XENLA --RYDMGG-LQYSP-MMSSAQ-TYMNAAAST-----Y-SMSP--------AYNQQSST-- SOX3A_XENLA SOX3A_XENLA --RYDMSG-LQYNP-MMTSAQNAYMNAAAST-----Y-SMSP--------AYNQQSST-- SOX3_XENTR SOX3_XENTR --RYDMGG-LQYSPMMSSAQ--TYMNAAAST-----Y-SMSP--------AYNQQSST-- B6VFL0_BOMOR B6VFL0_BOMOR --RYDMTG-LQYSP-MMSSAQ-TYMN-AAST-----Y-SMSP--------VYNQQTST-- A7VKI3_RANRU A7VKI3_RANRU --RYDMSS-LQYNP-MMSSAQ-TYMN-AAST-----Y-SMSP--------AYNQQTST-- MATCH * : CONSENSUS ??RYD????LQY???????????YM???????????Y??????????????Y??Q?????

Q5FZN8_BRABE Q5FZN8_BRABE -------------------------------FLAGSQARTDTPTSLRT-----NHIRRTT Q9NB28_BRAFL Q9NB28_BRAFL ------------------------VSSYPSTDFCAPVKPERTLPASYD------------ Q86SB8_HALRO Q86SB8_HALRO GTPPYSNVLHQPHVPTVKSPDTS-PGGIG--HQTPSCHSGSSPGQTPI----AGQ-PQCP Q4S778_TETNG Q4S778_TETNG -----------------VSGAIG--GTLG--PLVKSE-PSVSPPVSAA----RAP-TSCP Q0Q579_BRAFL Q0Q579_BRAFL ------------------PQTMSSQMPPG-FTTVKTE-AGPAAPTGTPPADGRGR-NPCP SX19A_DANRE SX19A_DANRE ------------------------PSPVM--SMVKPEQVSHSPTGA------HSH-QRGP SX19B_DANRE SX19B_DANRE ------------------------PSPVM--SMVKPEPLSHSPTGVPN----HHR-GAFQ Q6I753_CYNPY Q6I753_CYNPY PP--------QGGSATSASSASGALGALG--SLVKSE-PSVSPPVSGSAVHPSAR-APCP O57401_CHICK O57401_CHICK -----NSAAAAAAAAAAAAASSGALGALG--SLVKSE-PSVSPPVTS-----HSR-APCP SOX1_MOUSE SOX1_MOUSE AAGGAHQNSAVAAAAAAAAASSGALGALG--SLVKSE-PSGSPPAPA-----HSR-APCP Q80XF2_MOUSE Q80XF2_MOUSE AAGGAHQNSAVAAAAAAAAASSGALGALG--SLVKSE-PSGSPPAPA-----HSR-APCP SOX1_HUMAN SOX1_HUMAN AAGGAHQNSAVAAAAAAAAASSGALGALG--SLVKSE-PSGSPPAPA-----HSR-APCP SOX1B_DANRE SOX1B_DANRE -----------------SVASSGAIGALG--SLVKSE-PSVSPPVNA-----HSR-APCS Q4S0P5_TETNG Q4S0P5_TETNG -----------------SVSSSAAMGTLG--SLVKSE-PSVSPPVSST----HSR-GPCP SOX1A_DANRE SOX1A_DANRE -----------------SVATSAAIGTLS--SLVKSE-PNISPPVTT-----HSR-GPCP SOX2_XENLA SOX2_XENLA --------------------GMS-LGSMG--SVVKSE-SSSSPPVVTS----SSH-SRAP SOX2_CHICK SOX2_CHICK --------------------GMA-LGSMG--SVVKTE-SSSSPPVVTS----SSH-SRAP B4YQU0_BUBBU B4YQU0_BUBBU ------------------------------------------------------------ B6VA41_HORSE B6VA41_HORSE --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP SOX2_MOUSE SOX2_MOUSE --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP B1Q0D1_PIG B1Q0D1_PIG --------------------GMT-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP Q3UES8_MOUSE Q3UES8_MOUSE --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP Q3V2B6_MOUSE Q3V2B6_MOUSE --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP Q60I23_MOUSE Q60I23_MOUSE --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP B2R6J0_HUMAN B2R6J0_HUMAN --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP A2VDX8_BOVIN A2VDX8_BOVIN --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP B8XIA2_MACMU B8XIA2_MACMU --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP SOX2_HUMAN SOX2_HUMAN --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP SOX2_SHEEP SOX2_SHEEP --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP B1PXF9_PIG B1PXF9_PIG --------------------GMA-LGSMG--SVVKSE-ASSSPPVVTS----SSH-SRAP Q38Q18_PIG Q38Q18_PIG --------------------GMA-LGSMG--SVVKSE-ASSSPPV--------------- Q08G14_ACISC Q08G14_ACISC --------------------GMT-LGSMG--AVVKSE-SSSSPPVVTS----SSH-SRAP B5X176_SALSA B5X176_SALSA --------------------GMT-LGSMG--SVVKSE-SSSSPPVVTS----SSHSRGAP B5LEE1_9TELE B5LEE1_9TELE --------------------GMT-LGSMG--SVVKSE-SSSSPPVVTS----SSH-SRAG SOX2_DANRE SOX2_DANRE --------------------GMT-LGSMG--SVVKSE-SSSSPPVVTS----SSH-SRAG Q09HM9_GADMO Q09HM9_GADMO --------------------GMTALGSMGPSSVVKSESSSSSPPVVTS----SSH-RAAP A4GU07_OREMO A4GU07_OREMO --------------------GMTALGSMGPSSVVKSESSSSSPPVVTS----SS------ Q4T665_TETNG Q4T665_TETNG --------------------GMTALGSMGPSSVVKSESSSSSPPVVTS----SSH-RAAP B7U506_EPICO B7U506_EPICO --------------------GMTALGSMGPSSVVKSESSSSSPPVVTS----SSH-RAAP A4GU04_ORENI A4GU04_ORENI --------------------GMTALGSMGPSSVVKSESSSSSPPVVTS----SSH-RAAP A4GU05_OREAU A4GU05_OREAU --------------------GMTALGSMGPSSVVKSESSSSSPPVVTS----SSH-RAAP A4GU06_9CICH A4GU06_9CICH --------------------GMTALGSMGPSSVVKSESSSSSPPVVTS----SSH-RAAP Q28848_SMIMA Q28848_SMIMA -------------------------------------------PAVQP----HDAGRP-- SOX3_HUMAN SOX3_HUMAN -----------AAAAAAAAAAMS-LGPMG--SVVKSE-PSSPPPAIAS----HSQ-RACL SOX3_MOUSE SOX3_MOUSE -----------AAAAAAAAAAMS-LGPMG--SVVKSE-PSSPPPAIRS----HSQ-RACL Q6P564_MOUSE Q6P564_MOUSE -----------AAAAAAAAAAMS-LGPMG--SVVKSE-PSSPPPAIAS----HSQ-RACL Q5RKW0_MOUSE Q5RKW0_MOUSE -----------AAAAAAAAAAMS-LGPMG--SVVKSE-PSSPPPAIAS----HSQ-RACL Q4VBD8_MOUSE Q4VBD8_MOUSE -----------AAAAAAAAAAMS-LGPMG--SVVKSE-PSSPPPAIAS----HSQ-RACL A2AM37_MOUSE A2AM37_MOUSE -----------AAAAAAAAAAMS-LGPMG--SVVKSE-PSSPPPAIAS----HSQ-RACL Q80XF1_MOUSE Q80XF1_MOUSE -----------AAAAAAAAAAMS-LGPMG--SVVKSE-PSSPPPAIAS----HSQ-RACL B7T0X1_RAT B7T0X1_RAT --------------------------------------AAAAAAAAAA------------ Q4RP71_TETNG Q4RP71_TETNG --------------------AMG-LSSMA--SVCKTE-PSSPPPAITS----HSQ-RACL A5Z1E1_ACASC A5Z1E1_ACASC --------------------AMG-LSSMA--SVCKTE-PSSPPPAITS----HSQ-RACL Q9PT76_ORYLA Q9PT76_ORYLA --------------------AMG-LSSMG--SVCKTE-PSSPPPAITS----HSQ-RACL Q06B63_LATCA Q06B63_LATCA --------------------AMG-LSSMA--SVCKTE-PSSPPPAITS----HSQ-RACL Q38KZ5_EPICO Q38KZ5_EPICO --------------------AMG-LSSMA--SVCKTE-PSSPPPAITS----HSQ-RACL B5LSX2_9LABR B5LSX2_9LABR --------------------AMG-LSSMA--SVCKTE-PSSPPPAITS----HSQ-RACL A2I8A8_CARAU A2I8A8_CARAU --------------------AMG-LGSIA--SVCKTE-PSSPPPAITS----HSQ-RACL A9JSZ3_DANRE A9JSZ3_DANRE --------------------AMG-LGSMA--SVCKTE-PSSPPPAITS----HSQ-RACL SOX3_DANRE SOX3_DANRE --------------------AMG-LGSMA--SVCKTE-PSSPPPAITS----HSQ-RACL SOX3_CHICK SOX3_CHICK --------------------AMS-LGSMG--SVVKSE-PSSAPPAITS----HSQ-RACL Q2F7Y8_TAEGU Q2F7Y8_TAEGU --------------------AMS-LGSMG--SVVKSE-PSSPPPAITS----HSQ-RACL Q9PSV6_CHICK Q9PSV6_CHICK --------------------AMS-LGSMG--SVVKSE-PSSPPPAITS----HSQ-RACL SOX3B_XENLA SOX3B_XENLA --------------------VMS-LASMG--SVVKSE-PSSPPPAITS----HTQ-RACL SOX3A_XENLA SOX3A_XENLA --------------------VMS-LASMG--SVVKSE-PSSPPPAITS----HTQ-RACL SOX3_XENTR SOX3_XENTR --------------------VMS-LGSMG--SVVKSE-PSSPPPAITS----HTQ-RACL B6VFL0_BOMOR B6VFL0_BOMOR --------------------AMS-LGSMG--SVVKSE-PSSPPPAITS----HTQ-RACL A7VKI3_RANRU A7VKI3_RANRU --------------------VMS-LGSMG--SVVKSE-PSSPPPAITS----HTQ-RACL MATCH CONSENSUS ????????????????????????L??????S??K?E??S??PP????????????????

Q5FZN8_BRABE Q5FZN8_BRABE -----GE------------------------------------------HC--------- Q9NB28_BRAFL Q9NB28_BRAFL -----------------------DH----------------IRP-----YYSE------- Q86SB8_HALRO Q86SB8_HALRO PQAQAGQIQSMISMYLPHSEHAGVTPVPSSSPAMDNSRLASMQP----AHYSIPLTSGVH Q4S778_TETNG Q4S778_TETNG ----TGDLRDMISMYL-PGGEAGAA---EP---GVHSRLHVLHP----QHYPSG--GSGP Q0Q579_BRAFL Q0Q579_BRAFL -----GDLREMISMYLP--GDANDP---NA-----QSRLHSMQG-----HYQN----SVG SX19A_DANRE SX19A_DANRE ---LQGDLRDMISMYI-PGGDTTDS---GA-----QRGYSNIQQ-----HYLT------- SX19B_DANRE SX19B_DANRE -----GDLRDMISMYI-PGGDTSES---SN-----QRAYPGVQQ-----HYLG------- Q6I753_CYNPY Q6I753_CYNPY -----GDLREMISMYL-PAGEAAEA----A--AAGGRLLHGLSQPQQQAHYHH---HQSA O57401_CHICK O57401_CHICK -----GDLREMISMYL-PGGEGGDPAAAAA-----QSRLHSLPQ-----HYQS---ASTG SOX1_MOUSE SOX1_MOUSE -----GDLREMISMYL-PAGEGGDPAAAAA--AAAQSRLHSLPQ-----HYQG---AGAG Q80XF2_MOUSE Q80XF2_MOUSE -----GDLREMISMYL-PAGEGGDPAAAAA--AAAQSRLHSLPQ-----HYQG---AGAG SOX1_HUMAN SOX1_HUMAN -----GDLREMISMYL-PAGEGGDPAAAAA--AAAQSRLHSLPQ-----HYQG---AGAG SOX1B_DANRE SOX1B_DANRE -----GDLREMISMYL-PTAEAGDP---SV-----QSRLHAVPQ-----HYQS---STTS Q4S0P5_TETNG Q4S0P5_TETNG -----GDLREMISMYL-PTGEPGDP---SM-----QSRLHALPQ-----HYQS---ATAG SOX1A_DANRE SOX1A_DANRE -----GDLREMISMYL-PTGESGDP---SV-----QSRLHALPQ-----HYQS---TTAG SOX2_XENLA SOX2_XENLA --CQAGDLRDMISMYL-PGAEVPES---AA-----QSRLH-MSQ-----HYQSASVAGTG SOX2_CHICK SOX2_CHICK --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSAPVPGTA B4YQU0_BUBBU B4YQU0_BUBBU ------------------------------------------------------------ B6VA41_HORSE B6VA41_HORSE --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA SOX2_MOUSE SOX2_MOUSE --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MAQ-----HYQSGPVPGTA B1Q0D1_PIG B1Q0D1_PIG --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA Q3UES8_MOUSE Q3UES8_MOUSE --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MAQ-----HYQSGPVPGTA Q3V2B6_MOUSE Q3V2B6_MOUSE --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MAQ-----HYQSGPVPGTA Q60I23_MOUSE Q60I23_MOUSE --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MAQ-----HYQSGPVPGTA B2R6J0_HUMAN B2R6J0_HUMAN --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA A2VDX8_BOVIN A2VDX8_BOVIN --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA B8XIA2_MACMU B8XIA2_MACMU --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA SOX2_HUMAN SOX2_HUMAN --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA SOX2_SHEEP SOX2_SHEEP --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA B1PXF9_PIG B1PXF9_PIG --CQAGDLRDMISMYL-PGAEVPEP---AA-----PSRLH-MSQ-----HYQSGPVPGTA Q38Q18_PIG Q38Q18_PIG ------------------------------------------------------------ Q08G14_ACISC Q08G14_ACISC -QCQPGDLRDMISMYL-PGAEVPES---TA-----QSRLH-MSQ-----HYQSAPVPG-- B5X176_SALSA B5X176_SALSA --CQTGDLRDMISMYL-PGAEVPEQ---TA-----QSRLH-MSQ-----HYQSAPVPGTT B5LEE1_9TELE B5LEE1_9TELE -QCQTGDLRDM--------------------------RLW-------------------- SOX2_DANRE SOX2_DANRE -QCQTGDLRDMISMYL-PGAEVQDQ---SA-----QSRLH-MSQ-----HYQSAPVPGTT Q09HM9_GADMO Q09HM9_GADMO -GCQSGDLRDMISMYL-PGAEVSEQ---TA-----QTRLH-MSG-----HYQSA-VPGST A4GU07_OREMO A4GU07_OREMO ------------------------------------------------------------ Q4T665_TETNG Q4T665_TETNG -GCQSGDLRDMISMYL-PGTEVSEQ---GA-----QTRLH-MPG-----HYQST-VPGTT B7U506_EPICO B7U506_EPICO -GCQSGDLRDMISMYL-PGAEVSEQ---SA-----QTRLH-MSG-----HYQS------- A4GU04_ORENI A4GU04_ORENI -GCQSGDLRDMISMYL-PGAEVSEP---TA-----QTRLH-MSG-----HYQST------ A4GU05_OREAU A4GU05_OREAU -GCQSGDLRDMISMYL-PGAEVSEP---TA-----QTRLH-MSG-----HYQST------ A4GU06_9CICH A4GU06_9CICH -GCQSGDLRDMISMY--------------------------------------------- Q28848_SMIMA Q28848_SMIMA ------DLHELL------------------------------------------------ SOX3_HUMAN SOX3_HUMAN -----GDLRDMISMYLPPGGDAADA---AS--PLPGGRLHGVHQ-----HYQG---AGTA SOX3_MOUSE SOX3_MOUSE -----GDLRDMISMYLPPGGDAADA---AS--PLPGGRLHGVHQ-----HYQG---AGTA Q6P564_MOUSE Q6P564_MOUSE -----GDLRDMISMYLPPGGDAADA---AS--PLPGGRLHGVHQ-----HYQG---AGTA Q5RKW0_MOUSE Q5RKW0_MOUSE -----GDLRDMISMYLPPGGDAADA---AS--PLPGGRLHGVHQ-----HYQG---AGTA Q4VBD8_MOUSE Q4VBD8_MOUSE -----GDLRDMISMYLPPGGDAADA---AS--PLPGGRLHGVHQ-----HYQG---AGTA A2AM37_MOUSE A2AM37_MOUSE -----GDLRDMISMYLPPGGDAADA---AS--PLPGGRLHGVHQ-----HYQG---AGTA Q80XF1_MOUSE Q80XF1_MOUSE -----GDLRDMISMYLPPGGDAADA---AS--PLPGGRLHGVHQ-----HYQG---AGTA B7T0X1_RAT B7T0X1_RAT -------------MSLGP------------------------------------------ Q4RP71_TETNG Q4RP71_TETNG -----GDLRDMISMYLPPGGDSAEH---SS---LQSSRLHSVHP-----HYQS---AGTG A5Z1E1_ACASC A5Z1E1_ACASC -----GDLRDMISMYLPPGGDSAEH---SS---LQSSRLHSVHP-----HYQT---AGTA Q9PT76_ORYLA Q9PT76_ORYLA -----GDLRDMISMYLPPGGDSAEH---SS---LQSSRLHSVHP-----HYQS---AGTG Q06B63_LATCA Q06B63_LATCA -----GDLRDMISMYLPPGGDSAEH---SS---LQSSRLHSVHP-----HYQT---AGTG Q38KZ5_EPICO Q38KZ5_EPICO -----GDLRDMISMYLPPGGDSAEH---SS---LQSSRLHSVHP-----HYQT---AGTG B5LSX2_9LABR B5LSX2_9LABR -----GDLRDMISMYLPPGGDSAEH---SS---LQSSRLHSVHP-----HYQS---AGTG A2I8A8_CARAU A2I8A8_CARAU -----GDLRDMISMYLPPGGDSADH---AS---LQSSRLHSVHP-----HYQS---AGTG A9JSZ3_DANRE A9JSZ3_DANRE -----GDLRDMISMYLPPGGDSADH---SS---LQTSRLHSVHP-----HYQS---AGTG SOX3_DANRE SOX3_DANRE -----GDLRDMISMYLPPGGDSADH---SS---LQTSRLHSVHP-----HYQS---AGTG SOX3_CHICK SOX3_CHICK -----GELRDMISMYLGPGGDATHP---SA---LQGSRLHSVHQ-----HYQS---AGTR Q2F7Y8_TAEGU Q2F7Y8_TAEGU -----GDLRDMISMYLPPGGDATDP---SA---LQGSRLHSVHQ-----HYQS---AGTA Q9PSV6_CHICK Q9PSV6_CHICK -----GDLRDMISMYLPPGGDATDP---SA---LQGSRLHSVHQ-----HYQS---AGTA SOX3B_XENLA SOX3B_XENLA -----GDLRDMISMYLPPGGDAGDH---SS---LQNSRLHSVHQ-----HYQSA--GGPG SOX3A_XENLA SOX3A_XENLA -----GDLRDMISMYLPPGGDASDP----S---LQNSRLHSVHQ-----HYQSA--AGPG SOX3_XENTR SOX3_XENTR -----GDLRDMISMYLPPGGDASDP---SS---LQSSRLHSVHQ-----HYQS----AAG B6VFL0_BOMOR B6VFL0_BOMOR -----GDLRDMISMYLPPGGDANDP---SS---LQSSRLHSVHQ-----HYQS---AGTG A7VKI3_RANRU A7VKI3_RANRU -----GDLRDMISMYLPPGGDASDP---SS---LQNSRLHSVHQ-----HYQS---AGTA MATCH CONSENSUS ?????GDLR?MISMYL?P???????????????????RLH?????????HY?????????

Q5FZN8_BRABE Q5FZN8_BRABE ---------- Q9NB28_BRAFL Q9NB28_BRAFL --------HC Q86SB8_HALRO Q86SB8_HALRO IPHMHTMSNM Q4S778_TETNG Q4S778_TETNG GGGTVPLTHI Q0Q579_BRAFL Q0Q579_BRAFL VNGTVPLSHM SX19A_DANRE SX19A_DANRE --GTAPLTHI SX19B_DANRE SX19B_DANRE --GTVPLTHI Q6I753_CYNPY Q6I753_CYNPY VNGTVPLTHI O57401_CHICK O57401_CHICK VNGTVPLTHI SOX1_MOUSE SOX1_MOUSE VNGTVPLTHI Q80XF2_MOUSE Q80XF2_MOUSE VNGTVPLTHI SOX1_HUMAN SOX1_HUMAN VNGTVPLTHI SOX1B_DANRE SOX1B_DANRE VNGTVPLTHI Q4S0P5_TETNG Q4S0P5_TETNG VNGTVPLTHI SOX1A_DANRE SOX1A_DANRE VNGTVPLTHI SOX2_XENLA SOX2_XENLA INGTLPLSHM SOX2_CHICK SOX2_CHICK INGTLPLSHM B4YQU0_BUBBU B4YQU0_BUBBU ---------- B6VA41_HORSE B6VA41_HORSE INGTLPLSHM SOX2_MOUSE SOX2_MOUSE KYGTLPLSHM B1Q0D1_PIG B1Q0D1_PIG INGTLPLSHM Q3UES8_MOUSE Q3UES8_MOUSE INGTLPLSHM Q3V2B6_MOUSE Q3V2B6_MOUSE INGTLPLSHM Q60I23_MOUSE Q60I23_MOUSE INGTLPLSHM B2R6J0_HUMAN B2R6J0_HUMAN INGTLPLSHM A2VDX8_BOVIN A2VDX8_BOVIN INGTLPLSHM B8XIA2_MACMU B8XIA2_MACMU INGTLPLSHM SOX2_HUMAN SOX2_HUMAN INGTLPLSHM SOX2_SHEEP SOX2_SHEEP INGTLPLSHM B1PXF9_PIG B1PXF9_PIG INGTLPLSHM Q38Q18_PIG Q38Q18_PIG ---------- Q08G14_ACISC Q08G14_ACISC ---------- B5X176_SALSA B5X176_SALSA INGTLPLSHM B5LEE1_9TELE B5LEE1_9TELE ---------- SOX2_DANRE SOX2_DANRE INGTIPLSHM Q09HM9_GADMO Q09HM9_GADMO INGTMPLTHM A4GU07_OREMO A4GU07_OREMO ---------- Q4T665_TETNG Q4T665_TETNG INGTLPLTHM B7U506_EPICO B7U506_EPICO ---TVP---- A4GU04_ORENI A4GU04_ORENI ---------- A4GU05_OREAU A4GU05_OREAU ---------- A4GU06_9CICH A4GU06_9CICH ---------- Q28848_SMIMA Q28848_SMIMA ---------- SOX3_HUMAN SOX3_HUMAN VNGTVPLTHI SOX3_MOUSE SOX3_MOUSE VNGTVPLTHI Q6P564_MOUSE Q6P564_MOUSE VNGTVPLTHI Q5RKW0_MOUSE Q5RKW0_MOUSE VNGTVPLTHI Q4VBD8_MOUSE Q4VBD8_MOUSE VNGTVPLTHI A2AM37_MOUSE A2AM37_MOUSE VNGTVPLTHI Q80XF1_MOUSE Q80XF1_MOUSE VNGTVPLTHI B7T0X1_RAT B7T0X1_RAT ---------- Q4RP71_TETNG Q4RP71_TETNG VNGTLPLTHI A5Z1E1_ACASC A5Z1E1_ACASC VNGTLPLTHI Q9PT76_ORYLA Q9PT76_ORYLA VNGTLPLTHI Q06B63_LATCA Q06B63_LATCA VNGNLPLTHI Q38KZ5_EPICO Q38KZ5_EPICO VNGTLPLTHI B5LSX2_9LABR B5LSX2_9LABR VNGTLPLTHI A2I8A8_CARAU A2I8A8_CARAU VNGTLPLTHI A9JSZ3_DANRE A9JSZ3_DANRE VNGTLPLTHI SOX3_DANRE SOX3_DANRE VNGTLPLTHI SOX3_CHICK SOX3_CHICK VNGTVPLTHI Q2F7Y8_TAEGU Q2F7Y8_TAEGU VNGTVPLTHI Q9PSV6_CHICK Q9PSV6_CHICK VNGTVPLTHI SOX3B_XENLA SOX3B_XENLA VNGTVPLTHI SOX3A_XENLA SOX3A_XENLA VNGTVPLTHI SOX3_XENTR SOX3_XENTR PNGTVPLTHI B6VFL0_BOMOR B6VFL0_BOMOR VNGTVPLT-- A7VKI3_RANRU A7VKI3_RANRU VNGTVPLTHI MATCH CONSENSUS ?????P????


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