Alignment of the gene Family HBG105711 of HOVERGEN

JalView . Download . SRS . Tree .
Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
A8IYK2_DANRE A8IYK2_DANRE -----MWPPQGPQCIISPKTVVLLGLL-TICNSPHHSEGALEPFRSFTP--PDWGLTHLA Q5U5A2_XENLA Q5U5A2_XENLA ----MLLHAGKPLLFHLWTFLVLLGSW------ITTGDGTPKGFRTFTG--SDWSLTHLV A2RUV3_XENTR A2RUV3_XENTR ----MLLHAEKPLPFHLWTFLVLLGSW------IAAGDGTPKSFRTFTG--TDWSLTHLV Q91823_XENLA Q91823_XENLA ----MLLHAERPLPFHLWTFLVLLGSW------IATGDGSPKDFRTFTG--SDWSLTHLV PLXA1_HUMAN PLXA1_HUMAN --MPLPPRSLQVLLLLLLLLLLLPGMW-AEAGLPRAGGGSQPPFRTFSG--SDWGLTHLL PLXA1_MOUSE PLXA1_MOUSE ----MPLPPLSSRTLLLLLLLLLRGVW-IAISSPPAGLGPQPAFRTFVA--SDWGLTHLV A5D6Q5_MOUSE A5D6Q5_MOUSE ---------MPTVCLLPLLFFTIGGCL-----------GSSRPFRTFVV--TDTTLTHLA P70208_MOUSE P70208_MOUSE ---------MPTVCLLPLLFFTIGGCL-----------GSSRPFRTFVV--TDTTLTHLA B5FW97_OTOGA B5FW97_OTOGA ---------MPAVCLLQLLLLTVGGAL-----------GNSRPFRAFMV--TDTTLTHLA B2KIK2_RHIFE B2KIK2_RHIFE ---------MPTVCLLLLLLLTMEGAL-----------CGSRPFPAFSV--TDTTLTHLA B7NZQ8_RABIT B7NZQ8_RABIT ---------MPTACVLLLFFLTVGRAV-----------GSTRSFRAFVV--TDTTLTHLA B1MTV7_CALMO B1MTV7_CALMO ---------MPSVCLLLLLFLAVGGAL------------GNRPFRAFVV--TDTTLTHLA A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN ---------MPSVCLLLLLFLAVGGAL------------GNRPFRAFVV--TDTTLTHLA Q4T5C4_TETNG Q4T5C4_TETNG ------------------------------------------------------------ A5JJU2_DANRE A5JJU2_DANRE ---------MRSLWLLVFSFSVLTGTN---MAFPMILSERPEVTGSFKV--KDTSLTHLT B0S5N4_DANRE B0S5N4_DANRE ---------MRSLWLLVFSFSVLTGTN---MAFPMILSERPEVTGSFKV--KDTSLTHLT B3DKK4_DANRE B3DKK4_DANRE ---------MRSLWLLVFSFSVLTGTN---MAFPMILSERPEVTGSFKV--KDTSLTHLT A8IYK6_DANRE A8IYK6_DANRE ---------MRSLWLLVFSFSVLTGTN---MAFPMILSERPEVTGSFKV--KDTSLTHLT Q4S650_TETNG Q4S650_TETNG ------------------------------------------------------------ B1WB12_XENTR B1WB12_XENTR EQRRILMWTQGPVRLQYWASSSVLIVL----AMLSLDFPCASLSNTFNTEHRDWTFSHLT PLXA2_HUMAN PLXA2_HUMAN --MEQRRPWPRALEVDSRSVVLLSVVW----VLLAPPAAGMPQFSTFHSENRDWTFNHLT PLXA2_MOUSE PLXA2_MOUSE --MEQRRFYLRAMQADNLSVVLLSVAW----LLLARGTTGMPQYSTFHSENRDWTFNHLT B3DK42_DANRE B3DK42_DANRE MAFHNRRWNFTFSCCVVVLLLPLVAAR---PQQPSAATRVHEEYSTFRVENTEWTFNHLA PLXA4_DANRE PLXA4_DANRE MAFHNRRWNFTFSCCVVVLLLPLVAAR---PQQPSAATRVHEEYSTFRVENTEWTFNHLA B7WNM6_HUMAN B7WNM6_HUMAN --MKAMPWNWT--CLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAE-GFNHLV PLXA4_HUMAN PLXA4_HUMAN --MKAMPWNWT--CLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAE-GFNHLV B9EJ29_MOUSE B9EJ29_MOUSE -----MPWNWT--CLLSHLLVVGMGSSTLLPRQPPQLSQK-PSFVTFRGEPAE-GFNHLV PLXA4_MOUSE PLXA4_MOUSE --MKAMPWNWT--CLLSHLLVVGMGSSTLLPRQPPQLSQK-PSFVTFRGEPAE-GFNHLV MATCH CONSENSUS ??????????????????????????????????????????????F??????????HL?

A8IYK2_DANRE A8IYK2_DANRE IHNKTGDVYVGAVNWIYKLSSNLTKLRSHVTGPVVDNEKCYPPPSVQSCPHDLSPNSNVN Q5U5A2_XENLA Q5U5A2_XENLA VHNKTGEVYLGAINRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGLFTTNNVN A2RUV3_XENTR A2RUV3_XENTR VHNKTGEVYLGAINRIYKLSNNLTLMRTHVTGPVEDNEKCYPPPSVQSCPHGLVSTNNVN Q91823_XENLA Q91823_XENLA VHNKTGEVYVGAINRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGLITTNNVN PLXA1_HUMAN PLXA1_HUMAN VHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGNTDNVN PLXA1_MOUSE PLXA1_MOUSE VHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDNVN A5D6Q5_MOUSE A5D6Q5_MOUSE VHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVN P70208_MOUSE P70208_MOUSE VHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVN B5FW97_OTOGA B5FW97_OTOGA VHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNSRCYPPPSMRACAHHLAPVDNVN B2KIK2_RHIFE B2KIK2_RHIFE VHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCTHRLAPVDNVN B7NZQ8_RABIT B7NZQ8_RABIT VHRVTGEVFVGAVNRVFKLASNLTELRAHVTGPVEDNAHCYPPPSMRVCAHRLAPADNVN B1MTV7_CALMO B1MTV7_CALMO VHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNIN A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN VHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNIN Q4T5C4_TETNG Q4T5C4_TETNG -----------------------MCARAKKRKFGEDGGK--------------------- A5JJU2_DANRE A5JJU2_DANRE VHRKTGEVFVGAINRVYKLSANLTETRSHQTGPVEDNAKCYPPPSVRACTQKLESTDNVN B0S5N4_DANRE B0S5N4_DANRE VHRKTGEVFVGAINRVYKLSANLTETRSHQTGPVEDNAKCYPPPSVRACTQKLESTDNVN B3DKK4_DANRE B3DKK4_DANRE VHRKTGEVFVGAINRVYKLSANLTETRSHQTGPVEDNAKCYPPPSVRACTQKLESTDNVN A8IYK6_DANRE A8IYK6_DANRE VHRKTGEVFVGAINRIYKLSANLTETRSHQTGPVEDNAKCYPPPSVRACTQKLESTDNVN Q4S650_TETNG Q4S650_TETNG ------------------------------------------------------------ B1WB12_XENTR B1WB12_XENTR VHQTTGAVYVGAVNRIYKLSGNLTLLVSHNTGPGEDNKSCYPPQNVQPCSEPRTLTNNVN PLXA2_HUMAN PLXA2_HUMAN VHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVN PLXA2_MOUSE PLXA2_MOUSE VHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVLTLTNNVN B3DK42_DANRE B3DK42_DANRE VDHRNGNVYLGAVNRIYKLSPGLDIQVSHQTGPDEDNRNCYPPRIVQPCSEPLTLTNNVN PLXA4_DANRE PLXA4_DANRE VDHRNGNVYLGAVNRIYKLSPGLDIQVSHQTGPDEDNRNCYPPRIVQPCSEPLTLTNNVN B7WNM6_HUMAN B7WNM6_HUMAN VDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVN PLXA4_HUMAN PLXA4_HUMAN VDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVN B9EJ29_MOUSE B9EJ29_MOUSE VDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLASTNNVN PLXA4_MOUSE PLXA4_MOUSE VDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLASTNNVN MATCH CONSENSUS V???TG????GA?NR??KL???L?????H?TGP?EDN??CYPP?????C???L????NVN

A8IYK2_DANRE A8IYK2_DANRE KLLLIDYPQNRLIACGSTSQGICQFLRLDDLFKLGEPHHRKEHYLSSVVESGTMSGVIIS Q5U5A2_XENLA Q5U5A2_XENLA KLLLVDYADNRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIE A2RUV3_XENTR A2RUV3_XENTR KLLLIDYSENRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIE Q91823_XENLA Q91823_XENLA KLLLIDYSDNRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIE PLXA1_HUMAN PLXA1_HUMAN KLLLLDYAANRLLACGSASQGICQSLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIA PLXA1_MOUSE PLXA1_MOUSE KLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVREAGSMAGVLIA A5D6Q5_MOUSE A5D6Q5_MOUSE KLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVE P70208_MOUSE P70208_MOUSE KLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVE B5FW97_OTOGA B5FW97_OTOGA KLLLIDYAAHRLVACGSTWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVE B2KIK2_RHIFE B2KIK2_RHIFE KLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVE B7NZQ8_RABIT B7NZQ8_RABIT KLLLIDYAARRLVACGSVWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVE B1MTV7_CALMO B1MTV7_CALMO KLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVE A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN KLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVE Q4T5C4_TETNG Q4T5C4_TETNG --------------------GEAVFVELRKLLLL-------------------------- A5JJU2_DANRE A5JJU2_DANRE KLLLVDYAGNRLAACGSIWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAKESDGMAGVVVG B0S5N4_DANRE B0S5N4_DANRE KLLLVDYAGNRLVACGSIWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAKESDGMAGVVVG B3DKK4_DANRE B3DKK4_DANRE KLLLVDYAGNRLVACGSIWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAKESDGMAGVVVG A8IYK6_DANRE A8IYK6_DANRE KLLLVDYAGNRLVACGSIWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAKESDGMAGVVVG Q4S650_TETNG Q4S650_TETNG ------MAENQRLRRGR------------------------------------------- B1WB12_XENTR B1WB12_XENTR KLLIIDYAENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNETGTMYGVIVH PLXA2_HUMAN PLXA2_HUMAN KLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVR PLXA2_MOUSE PLXA2_MOUSE KLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVR B3DK42_DANRE B3DK42_DANRE KMLLMDYRENRLLACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVS PLXA4_DANRE PLXA4_DANRE KMLLMDYRENRLLACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVS B7WNM6_HUMAN B7WNM6_HUMAN KMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVS PLXA4_HUMAN PLXA4_HUMAN KMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVS B9EJ29_MOUSE B9EJ29_MOUSE KMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPFHKKEHYLSGVNESGSVFGVIVS PLXA4_MOUSE PLXA4_MOUSE KMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPFHKKEHYLSGVNESGSVFGVIVS MATCH CONSENSUS K?L??DY???RL?ACGS??QG?C??LRL?DLF?L?EP?H?KEHYLS???E?????GV???

A8IYK2_DANRE A8IYK2_DANRE EGHL---------SKLFIGTPIDGKSEYFPTLSSRKLMANEEDADMFSFVHQDEFVSSQL Q5U5A2_XENLA Q5U5A2_XENLA VPNGQ--------NKLFVGTPIDGKSEYFPTLSSRKLLANEENAEMFSFVYQDEFVSSQL A2RUV3_XENTR A2RUV3_XENTR VPNGQ--------NKLFVGTPIDGKSEYFPTLSSRKLMGNEENAEMFGFVYQDEFVSSQL Q91823_XENLA Q91823_XENLA VPNGQ--------NKLFVGTPIDGKSEYFPTLSSRKLLGNEENAEMFGFVYQDEFVSSQL PLXA1_HUMAN PLXA1_HUMAN GPPGQ------GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQL PLXA1_MOUSE PLXA1_MOUSE GPPGQ------GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQL A5D6Q5_MOUSE A5D6Q5_MOUSE QVQGP--------SKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQI P70208_MOUSE P70208_MOUSE QVQGP--------SKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQI B5FW97_OTOGA B5FW97_OTOGA QGQGP--------SKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQI B2KIK2_RHIFE B2KIK2_RHIFE QGQGP--------SKLFVGTAVDGKSEYFPTLSSRKLISDEDSAEMFSLVYQDEFVSSQI B7NZQ8_RABIT B7NZQ8_RABIT QDQGP--------SKLFVGTAVDGKSEYFPTLSSRKLISNEDSADMFSLVYQDEFVSSQI B1MTV7_CALMO B1MTV7_CALMO QGQGP--------SKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQI A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN QGQGP--------SKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQI Q4T5C4_TETNG Q4T5C4_TETNG -------------SPMLVA----------------------------------------- A5JJU2_DANRE A5JJU2_DANRE DDDGDLKKKKKGGSRLFIGAAIDGKSEYFPTLSSRKLVADEESVNMFSLVYQDEFVSSQI B0S5N4_DANRE B0S5N4_DANRE DDDGDLKKKKKGGSRLFIGAAIDGKSEYFPTLSSRKLVADEESVNMFSLVYQDEFVSSQI B3DKK4_DANRE B3DKK4_DANRE DDDGDLKKKKKGGSRLFIGAAIDGKSEYFPTLSSRKLVADEESVNMFSLVYQDEFVSSQI A8IYK6_DANRE A8IYK6_DANRE DDEGDLKKKKKGGSRLFIGAAIDGKSEYFPTLSSRKLVADEESVNMFSLVYQDEFVSSQI Q4S650_TETNG Q4S650_TETNG ------------------------------------------------------------ B1WB12_XENTR B1WB12_XENTR TEGQD--------GKLFIGTAVDGKQDYFPTLSSRKLPRDPESSTMLDYELYSDFVSSLI PLXA2_HUMAN PLXA2_HUMAN SEGED--------GKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLI PLXA2_MOUSE PLXA2_MOUSE SEGED--------GKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLI B3DK42_DANRE B3DK42_DANRE YGDAS-------PDKLFVATAVDGRPEYFPTISSRKLTRNSEEDGMFAYVFHDEFVASMI PLXA4_DANRE PLXA4_DANRE YGDAS-------PDKLFVATAVDGRPEYFPTISSRKLTRNSEEDGMFAYVFHDEFVASMI B7WNM6_HUMAN B7WNM6_HUMAN YSNLD--------DKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMI PLXA4_HUMAN PLXA4_HUMAN YSNLD--------DKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMI B9EJ29_MOUSE B9EJ29_MOUSE YSNFD--------DKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMI PLXA4_MOUSE PLXA4_MOUSE YSNFD--------DKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMI MATCH CONSENSUS ???????????????LF?????DGK??YFPT?SSRKL????????M????????FV?S??

A8IYK2_DANRE A8IYK2_DANRE KIPSDTLSKFPAFDIYYIYSFSSEQFVYYLTLQLDTQLTS----PDASGEQFFTSKIVRL Q5U5A2_XENLA Q5U5A2_XENLA KIPSDTLSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTS----PDSTGEQFFTSKIVRL A2RUV3_XENTR A2RUV3_XENTR KIPSDTLSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTS----PDSTGEQFFTSKIVRL Q91823_XENLA Q91823_XENLA KIPSDTLSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTS----PDSTGEQFFTSKIVRL PLXA1_HUMAN PLXA1_HUMAN KIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTS----PDAAGEHFFTSKIVRL PLXA1_MOUSE PLXA1_MOUSE KIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTS----PDAAGEHFFTSKIVRL A5D6Q5_MOUSE A5D6Q5_MOUSE KIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTL----LDTAGEKFFTSKIVRM P70208_MOUSE P70208_MOUSE KIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTL----LDTAGEKFFTSKIVRM B5FW97_OTOGA B5FW97_OTOGA KIPSDTLSLYPAFDIYYVYGFVSASFVYFLTLQLDTQQTL----LDTAGEKFFTSKIVRM B2KIK2_RHIFE B2KIK2_RHIFE KIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTL----LDTAGEKFFTSKIVRM B7NZQ8_RABIT B7NZQ8_RABIT KIPSDTLSLYPAFDIYYVYGFVSASFVYFLTLQLDTQQTL----LDTAGEKFFTSKIVRM B1MTV7_CALMO B1MTV7_CALMO KIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTL----LDTAGEKFFTSKIVRM A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN KIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTL----LDTAGEKFFTSKIVRM Q4T5C4_TETNG Q4T5C4_TETNG ------------------------------------------------------------ A5JJU2_DANRE A5JJU2_DANRE KIPSDTLSQYPAFDIYYVYGFSSRTYIYFLTLQLDTQLTQ----VDVTGEKFFTSKIVRM B0S5N4_DANRE B0S5N4_DANRE KIPSDTLSQYPAFDIYYVYGFSSRTYIYFLTLQLDTQLTQ----VDVTGEKFFTSKIVRM B3DKK4_DANRE B3DKK4_DANRE KIPSDTLSQYPAFDIYYVYGFSSRTYIYFLTLQLDTQLTQ----VDVTGEKFFTSKIVRM A8IYK6_DANRE A8IYK6_DANRE KIPSDTLSQYPAFDIYYVYGFSSRTYIYFLTLQLDTQLTQ----VDVTGEKFFTSKIVRM Q4S650_TETNG Q4S650_TETNG -------------------GFAS----------------------------------TRL B1WB12_XENTR B1WB12_XENTR KIPSDTLALVSHFDIFYVYGFSSGNYVYFLTVQPETPEGI---SSNSANDLFYTSRIVRL PLXA2_HUMAN PLXA2_HUMAN KIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGV---AINSAGDLFYTSRIVRL PLXA2_MOUSE PLXA2_MOUSE KIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPDGM---AINSAGDLFYTSRIVRL B3DK42_DANRE B3DK42_DANRE KIPSDTFTVVPDFDIYYVYGFSSGNFVYFLTLQPEMGGGPTTGSSSAGREQVYTSKLVRL PLXA4_DANRE PLXA4_DANRE KIPSDTFTVVPDFDIYYVYGFSSGNFVYFLTLQPEMGGGPTTGSSSAGREQVYTSKLVRL B7WNM6_HUMAN B7WNM6_HUMAN KIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPP----GSTTKEQVYTSKLVRL PLXA4_HUMAN PLXA4_HUMAN KIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPP----GSTTKEQVYTSKLVRL B9EJ29_MOUSE B9EJ29_MOUSE KIPSDTFTVIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPP----GSTTKEQVYTSKLVRL PLXA4_MOUSE PLXA4_MOUSE KIPSDTFTVIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPP----GSTTKEQVYTSKLVRL MATCH CONSENSUS KIPSDT??????FDI?Y?Y?F?S????Y?LT?Q????????????????????TS??VR?

A8IYK2_DANRE A8IYK2_DANRE CIDDPRFYSYVEFPIGCTKDGVEYRLIQDAYLSKPGRQLANSLGVSEQEDILFTVFSQGQ Q5U5A2_XENLA Q5U5A2_XENLA CVDDPKFYSYVEFPIGCMKDGVEYRLIQDAYLSKPGKRLAKELGISEREDILFTVFSQGQ A2RUV3_XENTR A2RUV3_XENTR CVDDPKFYSYVEFPIGCIKDGVEYRLIQDAYLSKPGKRLAKELGISEREDILFTVFSQGQ Q91823_XENLA Q91823_XENLA CVDDPKFYSYVEFPIGCMKDGVEYRLIQDAYLSKPGKRLAKELGISEREDILFTVFSQGQ PLXA1_HUMAN PLXA1_HUMAN CVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQ PLXA1_MOUSE PLXA1_MOUSE CVNDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGQALAKQLGLAEDEEVLFTVFAQGQ A5D6Q5_MOUSE A5D6Q5_MOUSE CAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQ P70208_MOUSE P70208_MOUSE CAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQ B5FW97_OTOGA B5FW97_OTOGA CAGDSEFYSYVEFPIGCSWHGVEYRLVQSAHLAKPGLLLAQALGVPADEDILFTIFSQGQ B2KIK2_RHIFE B2KIK2_RHIFE CAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQ B7NZQ8_RABIT B7NZQ8_RABIT CAGDSEFYSYVEFPIGCSWHGVEYRLVQSAHLAKPGPLLAQALGVPADEDVLFTIFSQGQ B1MTV7_CALMO B1MTV7_CALMO CAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQ A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN CAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQ Q4T5C4_TETNG Q4T5C4_TETNG ------------------------------------------------------------ A5JJU2_DANRE A5JJU2_DANRE CSNDTEFYSYVEFPLGCTKDGVEYRLVQAAYKHRPGKILAQALGLSEDEDVLFVIFSQGQ B0S5N4_DANRE B0S5N4_DANRE CSNDTEFYSYVEFPLGCTKDGVEYRLVQAAYKHRPGKILAQALGLSEDEDVLFVIFSQGQ B3DKK4_DANRE B3DKK4_DANRE CSNDTEFYSYVEFPLGCTKDGVEYRLVQAAYKHRPGKILAQALGLSEDEDVLFVIFSQGQ A8IYK6_DANRE A8IYK6_DANRE CSNDTEFYSYVEFPLGCTKDGVEYRLVQAAYKHRPGKILAQALGLSEDEDVLFVIFSQGQ Q4S650_TETNG Q4S650_TETNG SFDAP----------------VELR----------------------------------- B1WB12_XENTR B1WB12_XENTR CKNDPKFHSYVSLPIGCTKNGVEYRLLQAAYLTKPGATLARSLKITTQDDVLFAIFSKGQ PLXA2_HUMAN PLXA2_HUMAN CKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQ PLXA2_MOUSE PLXA2_MOUSE CKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQ B3DK42_DANRE B3DK42_DANRE CKDDTAFNSYVEVPLGCVKGGVEYRLLQAAYLSKAGTILARSLGIGPDDDILYAVFSKGQ PLXA4_DANRE PLXA4_DANRE CKDDTAFNSYVEVPLGCVKGGVEYRLLQAAYLSKAGTILARSLGIGPDDDILYAVFSKGQ B7WNM6_HUMAN B7WNM6_HUMAN CKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQ PLXA4_HUMAN PLXA4_HUMAN CKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQ B9EJ29_MOUSE B9EJ29_MOUSE CKEDTAFNSYVEVPIGCERNGVEYRLLQAAYLSKAGAVLGRTLGVRPDDDLLFTVFSKGQ PLXA4_MOUSE PLXA4_MOUSE CKEDTAFNSYVEVPIGCERNGVEYRLLQAAYLSKAGAVLGRTLGVRPDDDLLFTVFSKGQ MATCH CONSENSUS C??D??F?SYV??P?GC???GVEYRL?Q?A?????G??L???L??????D?LF??FS?GQ

A8IYK2_DANRE A8IYK2_DANRE KNRVK-PPRESALCLFTLTKIKEKIKERIQSCYRGEGRLSLPWLLNKELPCINSPLQIDD Q5U5A2_XENLA Q5U5A2_XENLA KNRIK-PPKESVLCLFTLKKIKDKIKERIQSCYRGDGKLSLPWLLNKELGCINSPLQIDD A2RUV3_XENTR A2RUV3_XENTR KNRIK-PPKESVMCLFTLKKIKDKIKERIQSCYRGDGKLSLPWLLNKELGCINSPLQIDD Q91823_XENLA Q91823_XENLA KNRIK-PPKESVLCLFTLKKIKDKIKERIQSCYRGDGKLSLPWLLNKELGCINSPLQIDD PLXA1_HUMAN PLXA1_HUMAN KNRVK-PPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDD PLXA1_MOUSE PLXA1_MOUSE KNRVK-PPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDD A5D6Q5_MOUSE A5D6Q5_MOUSE KNRAN-PPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPLQING P70208_MOUSE P70208_MOUSE KNRAN-PPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPLQING B5FW97_OTOGA B5FW97_OTOGA KNRAS-PPRQTVLCLFTLSNINAHIRHRIQSCYRGEGTLALPWLLNKELPCINTPMQING B2KIK2_RHIFE B2KIK2_RHIFE KNRAS-PPRQTVLCLFTLSTINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQING B7NZQ8_RABIT B7NZQ8_RABIT KNRAS-PPRQTILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKEMPCINTPMQING B1MTV7_CALMO B1MTV7_CALMO KNRAS-PPRQTILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKDLPCINTPMQING A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN KNRAS-PPRQTILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQING Q4T5C4_TETNG Q4T5C4_TETNG ------------------------------------------------------------ A5JJU2_DANRE A5JJU2_DANRE KNRAN-PPRETVLCLFTLHQINLAMRERIKSCYRGEGKLSLPWLLNKELPCINTPKQIGD B0S5N4_DANRE B0S5N4_DANRE KNRAN-PPRETVLCLFTLHQINLAMRERIKSCYRGEGKLSLPWLLNKELPCINTPKQIGD B3DKK4_DANRE B3DKK4_DANRE KNRAN-PPRETVLCLFTLHQINLAMRERIKSCYRGEGKLSLPWLLNKELPCINTPKQIGD A8IYK6_DANRE A8IYK6_DANRE KNRAN-PPRETVLCLFTLHQINLAMRERIKSCYRGEGKLSLPWLLNKELPCINTPKQIGD Q4S650_TETNG Q4S650_TETNG -------SSDKHICFWPAEA---------------------------------------- B1WB12_XENTR B1WB12_XENTR KQYHH-PPDDSTLCVFPIKTINSLIKERLQSCYQGEGHLELNWLLGKDVQCTKAPVPIDD PLXA2_HUMAN PLXA2_HUMAN KQYHH-PPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDD PLXA2_MOUSE PLXA2_MOUSE KQYHH-PPDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQCTKAPVPIDD B3DK42_DANRE B3DK42_DANRE KRRPKESSQESALCVFTLKEINERIKDRLQSCYKGEGTLDLAWLKVKDISCSSALLTIDD PLXA4_DANRE PLXA4_DANRE KRRPKESSQESALCVFTLKEINERIKDRLQSCYKGEGTLDLAWLKVKDISCSSALLTIDD B7WNM6_HUMAN B7WNM6_HUMAN KRKMK-SLDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDD PLXA4_HUMAN PLXA4_HUMAN KRKMK-SLDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDD B9EJ29_MOUSE B9EJ29_MOUSE KRKMK-SLDESALCIFILKQINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDD PLXA4_MOUSE PLXA4_MOUSE KRKMK-SLDESALCIFILKQINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDD MATCH CONSENSUS K???????????LC?F????I??????R??SCY?G?G?L?L?WL??K???C??????I??

A8IYK2_DANRE A8IYK2_DANRE NFCGQDFNQPLGGTKTIEGTPLFIDKDDGMTSVAAYDYRGNTVVFAGTRNGRMKKILINS Q5U5A2_XENLA Q5U5A2_XENLA NFCGQDFNQPLGGTVTIEGTPLFLDKEDGMTSVAAYDYRGHTVVFAGTRSGRMKKILVDL A2RUV3_XENTR A2RUV3_XENTR NFCGQDFNQPLGGTVTIEGTPLFLDKEDGMTSVAAYDYRGHTVVFAGTRSGRMKKILVDL Q91823_XENLA Q91823_XENLA NFCGQDFNQPLGGTVTIEGTPLFLDKEDGMTSVAAYDYRGHTVVFAGTRSGRVKKILVDL PLXA1_HUMAN PLXA1_HUMAN DFRGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKILVDL PLXA1_MOUSE PLXA1_MOUSE DFCGQDFNQPLGGTVTIEGTPLFVDKEDGLTAVAAYDYQGRTVVFAGTRSGRIRKILVDL A5D6Q5_MOUSE A5D6Q5_MOUSE NFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDG P70208_MOUSE P70208_MOUSE NFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDG B5FW97_OTOGA B5FW97_OTOGA NFCGLVLNQPLGGLHVIEGLPLLADNTDGMASVAAYTYHQHSVVFIGTRSGSLKKVRVDG B2KIK2_RHIFE B2KIK2_RHIFE NFCGLVLNQPLGGLHVIEGLPLLYDGTDGMASVAAYTYHQHSVVFIGTRSGSLKKVRVDG B7NZQ8_RABIT B7NZQ8_RABIT NFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFVGTRSGSLKKVRVDS B1MTV7_CALMO B1MTV7_CALMO NFCGLVLNQPLGGLHVIEGLPLVADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDG A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN NFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDG Q4T5C4_TETNG Q4T5C4_TETNG ----------------------------------------------------VSQIRVDG A5JJU2_DANRE A5JJU2_DANRE DFCGLVLNQPLGGLMVIEGIPLFDDRTDGMASVAAYTYGDHSVVFVGTRSGHLKKIRVNG B0S5N4_DANRE B0S5N4_DANRE DFCGLVLNQPLGGLMVIEGIPLFDDRTDGMASVAAYTYGDHSVVFVGTRSGHLKKIRVNG B3DKK4_DANRE B3DKK4_DANRE DFCGLVLNQPLGGLMVIEGIPLFDDRTDGMASVAAYTYGDHSVVFVGTRSGHLKKIRVNG A8IYK6_DANRE A8IYK6_DANRE DFCGLVLNQPLGGLMVIEGIPLFDDRTDGMASVAAYTYGDHSVVFVGTRSGHLKKIRVNG Q4S650_TETNG Q4S650_TETNG ---------------------------------------GMGIVF--------------- B1WB12_XENTR B1WB12_XENTR NFCGLDINQPLGGSTMVEGVTLYTESRDRMTSLASYVYNNYSVVFVGTKSGRIKKIRADG PLXA2_HUMAN PLXA2_HUMAN NFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADG PLXA2_MOUSE PLXA2_MOUSE NFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADG B3DK42_DANRE B3DK42_DANRE NFCGLDMNAPLGVSEMVRGIPLFSESKDKMTSVIAYVYKNHSLAFVGTRGGRLKKIRVDG PLXA4_DANRE PLXA4_DANRE NFCGLDMNAPLGVSEMVRGIPLFSESKDKMTSVIAYVYKNHSLAFVGTRGGRLKKIRVDG B7WNM6_HUMAN B7WNM6_HUMAN NFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDG PLXA4_HUMAN PLXA4_HUMAN NFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDG B9EJ29_MOUSE B9EJ29_MOUSE NFCGLDMNAPLGVSEMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDG PLXA4_MOUSE PLXA4_MOUSE NFCGLDMNAPLGVSEMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDG MATCH CONSENSUS ?FCG???N?PLG??????G????????D???SV??Y?Y??????F?GT??G??KK?????

A8IYK2_DANRE A8IYK2_DANRE -VSPSRPALLYESVAVS-EGSPLLRDMLFSPDLQFIYTLTDKQVTRVPVERCSQYSTCSE Q5U5A2_XENLA Q5U5A2_XENLA SASSSYMAQQYENVVVH-EGNAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYESCDA A2RUV3_XENTR A2RUV3_XENTR -SASSHMAQQYENVVVH-EGNAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYETCDA Q91823_XENLA Q91823_XENLA SASSSHLVQQYENVVVH-EGNAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYESCDT PLXA1_HUMAN PLXA1_HUMAN SNPGGRPALAYESVVAQ-EGSPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCEL PLXA1_MOUSE PLXA1_MOUSE ANPSGRPALAYESVVAQ-EGNPILRDLVLSPNRQYLYAMTEKQVTQVPVESCVQYTSCEL A5D6Q5_MOUSE A5D6Q5_MOUSE ----SQDAQLYETVSVV-QGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAA P70208_MOUSE P70208_MOUSE ----SQDAQLYETVSVV-QGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAA B5FW97_OTOGA B5FW97_OTOGA ----SQDTHLYETVPVV-DGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAA B2KIK2_RHIFE B2KIK2_RHIFE ----SQDAHLYETVPVV-DGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCEA B7NZQ8_RABIT B7NZQ8_RABIT ----SQDAHLYETVPVV-DGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCEA B1MTV7_CALMO B1MTV7_CALMO ----SQDAHLYETVPVV-DGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCTA A9CB66_PAPAN A9CB66_PAPAN ------------------------------------------------------------ PLXA3_HUMAN PLXA3_HUMAN ----FQDAHLYETVPVV-DGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAA Q4T5C4_TETNG Q4T5C4_TETNG VPTASQNALLYETVTVV-EGKPILRDMVFSPDHQFIYLLSDRQVSRLPVESCEQYSSCSS A5JJU2_DANRE A5JJU2_DANRE VPPPSENALLYETVTVV-EGSPILRDMVFSPDYQYIYLLSDKQVSRLPVESCSQYSSCKT B0S5N4_DANRE B0S5N4_DANRE VPPPSENALLYETVTVV-EGSPILRDMVFSPDYQYIYLLSDKQVSRLPVESCSQYSSCKT B3DKK4_DANRE B3DKK4_DANRE VPPPSENALLYETVTVV-EGSPILRDMVFSPDYQYIYLLSDKQVSRLPVESCSQYSSCKT A8IYK6_DANRE A8IYK6_DANRE VPPPSENALLYETVTVV-EGSPILRDMVFSPDYQYIYLLSDKQVSRLPVESCSQYSSCKT Q4S650_TETNG Q4S650_TETNG -----------------------MIDVPHSSD----------VVTQVPIESCEQYGTCGE B1WB12_XENTR B1WB12_XENTR ---PPDGGIPYEVVNVTRDEIPLLRDMAFSTDNKYLYVMSERQVSRVEVEHCEQYSSCEE PLXA2_HUMAN PLXA2_HUMAN ---PPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGE PLXA2_MOUSE PLXA2_MOUSE ---PPHGGVQYEMVSVFKDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGE B3DK42_DANRE B3DK42_DANRE ---PTYGALQYETIQVV-DNGPILRDMAFSSDQHFLYVMSESQLTRVPVEACEQYSSCNE PLXA4_DANRE PLXA4_DANRE ---PTYGALQYETIQVV-DNGPILRDMAFSSDQHFLYVMSESQLTRVPVEACEQYSSCNE B7WNM6_HUMAN B7WNM6_HUMAN ---PRGNALQYETVQVV-DPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQSCGE PLXA4_HUMAN PLXA4_HUMAN ---PRGNALQYETVQVV-DPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQSCGE B9EJ29_MOUSE B9EJ29_MOUSE ---PKGNALQYETVQVV-DSGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYRSCGE PLXA4_MOUSE PLXA4_MOUSE ---PKGNALQYETVQVV-DSGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYRSCGE MATCH CONSENSUS ??????????YE?V?V?????P?LRD???S?D????Y?????Q????PVE?C?QY??C??

A8IYK2_DANRE A8IYK2_DANRE CLSSRDPHCGWCVLHNICSRRDRCERADEPQRFASRVDQCVELTVQPNNISVTMAEVQLV Q5U5A2_XENLA Q5U5A2_XENLA CLGSRDPHCGWCVLHNTCSRKDKCERADEFHRFSSDQHQCVQLTVHPKNISVTVSEVPMV A2RUV3_XENTR A2RUV3_XENTR CLGSRDPHCGWCVLHNMCSRKDKCERADELHRFTSDQRQCVQLTVHPRNISVTVSEVPMV Q91823_XENLA Q91823_XENLA CLGSRDPHCGWCVLHNMCSRKDKCERADELHRFTSDQRQCVQLTVHPKNISVTVSEVPMV PLXA1_HUMAN PLXA1_HUMAN CLGSRDPHCGWCVLHSICSRRDACERADEPQRFAADLLQCVQLTVQPRNVSVTMSQVPLV PLXA1_MOUSE PLXA1_MOUSE CLGSRDPHCGWCVLHSICSRQDACERAEEPQRFASDLLQCVQLTVQPRNVSVTMSQVPLV A5D6Q5_MOUSE A5D6Q5_MOUSE CLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELSKCIQVRVRPNNVSVTSSGVQLT P70208_MOUSE P70208_MOUSE CLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELSKCIQVRVRPNNVSVTSSGVQLT B5FW97_OTOGA B5FW97_OTOGA CLGSGDPHCGWCVLQHRCCREGACPGASAPHSFVEELSKCVQVRVRPNNVSVTSPGVQLT B2KIK2_RHIFE B2KIK2_RHIFE CLGSGDPHCGWCVLQHRCCREGACPGASALHGFAEELSKCVQVRVRPNNVSVTSPGVQLT B7NZQ8_RABIT B7NZQ8_RABIT CLGSGDPHCGWCVLQHRCCREGACPGASAPRGFAEELSKCVQVRVRPNNVSVTSAGVQLT B1MTV7_CALMO B1MTV7_CALMO CLGSGDPHCGWCVLQSRCCREGACPGASAPHGFAEELSKCVQVRVRPNNVSVTSPGVQLT A9CB66_PAPAN A9CB66_PAPAN ----------------------------------EELNKCVQVRVRPNNVSVMSPGVQLT PLXA3_HUMAN PLXA3_HUMAN CLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCVQVRVRPNNVSVTSPGVQLT Q4T5C4_TETNG Q4T5C4_TETNG CLGSGDPHCGWCVLFNMCSRQEACHKWEEPQHFNTRLDQCVDISVTPSNLSVTSPSTQLT A5JJU2_DANRE A5JJU2_DANRE CLGSGDPHCGWCVLHNKCSRKEACEKWAEPLHFSTELKQCVDITVTPDNMSVTSVSTQLS B0S5N4_DANRE B0S5N4_DANRE CLGSGDPHCGWCVLHNKCSRKEACEKWAEPLHFSTELKQCVDITVTPDNMSVTSVSTQLS B3DKK4_DANRE B3DKK4_DANRE CLGSGDPHCGWCVLHNKCSRKEACEKWAEPLHFSTELKQCVDITVTPDNMSVTSVSTQLS A8IYK6_DANRE A8IYK6_DANRE CLGSGDPHCGWCVLHNKCSRKEACEKWAEPLHFSTELKQCVDITVTPDNMSVTSVSTQLS Q4S650_TETNG Q4S650_TETNG CLSSGDPHCGWCVLHNICSQRSRCERADEPYRFAASITQCVKVSVYPASIAVSEPSVPLL B1WB12_XENTR B1WB12_XENTR CLSSGDPHCGWCVLHNTCSRKDKCERAHEPFRFADNMKQCVKVDVQPNSLPVSEHSLLLT PLXA2_HUMAN PLXA2_HUMAN CLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLS PLXA2_MOUSE PLXA2_MOUSE CLSSGDPHCGWCALHNMCSRRDKCQRAWEANRFAASISQCMSLEVHPNSISVSDHSRLLS B3DK42_DANRE B3DK42_DANRE CLGSGDPHCGWCVLHSMCTRKEKCERSSEPRRFASNIKQCVRLSVHPNNISVSQYSVMLV PLXA4_DANRE PLXA4_DANRE CLGSGDPHCGWCVLHSMCTRKEKCERSSEPRRFASNIKQCVRLSVHPNNISVSQYSVMLV B7WNM6_HUMAN B7WNM6_HUMAN CLGSGDPHCGWCVLHNTCTRKERCERSKEPRRFASEMKQCVRLTVHPNNISVSQYNVLLV PLXA4_HUMAN PLXA4_HUMAN CLGSGDPHCGWCVLHNTCTRKERCERSKEPRRFASEMKQCVRLTVHPNNISVSQYNVLLV B9EJ29_MOUSE B9EJ29_MOUSE CLGSGDPHCGWCVLHNTCTRKERCERSREPRRFASEMKQCVRLTVHPNNISVSQYNVLLV PLXA4_MOUSE PLXA4_MOUSE CLGSGDPHCGWCVLHNTCTRKERCERSREPRRFASEMKQCVRLTVHPNNISVSQYNVLLV MATCH :*: : * * .:.* : CONSENSUS CL?S?DPHCGWCVL???C?R???C????????F??????CV???V?P?N?SV??????L?

A8IYK2_DANRE A8IYK2_DANRE LQARNVPDLSAGVDCSFEDYTQTEGTI-HGSRIYCLSPTAKELVPITRLQRDTHVLKLYL Q5U5A2_XENLA Q5U5A2_XENLA LQAWNVPDLSAGVNCSFEDFTEMEGRI-LDGNIYCTSPSAKEVIPITRGHGDKRVVKLYL A2RUV3_XENTR A2RUV3_XENTR LQAWNVPDLSAGVNCSFEDFTEMEGRI-LDGKIYCTSPSTKDVIPITRGHGDKRVLKLYL Q91823_XENLA Q91823_XENLA LQAWNVPDLSAGVNCSFEDFTEMEGRI-LDGKIYCTSPSAKEVIPITRGHGDKRVVKLYL PLXA1_HUMAN PLXA1_HUMAN LQAWNVPDLSAGVNCSFEDFTESESVL-EDGRIHCRSPSAREVAPITRGQGDQRVVKLYL PLXA1_MOUSE PLXA1_MOUSE LQAWNVPDLSAGVNCSFEDFTETESIL-EDGRIHCHSPSAREVAPITQGQGDQRVVKLYL A5D6Q5_MOUSE A5D6Q5_MOUSE VAMRNVPDLSVGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQL P70208_MOUSE P70208_MOUSE VAMRNVPDLSVGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQL B5FW97_OTOGA B5FW97_OTOGA VAVRNVPDLSAGVSCVFEEVMKSEAVLLPSGELHCLSPSLQELQALTRGHGSTRTVQLQL B2KIK2_RHIFE B2KIK2_RHIFE VAMRNVPDLSAGVSCAFEEVTENKAILLPSGELRCPSPSLQELQALTRGHGATRTVRLQL B7NZQ8_RABIT B7NZQ8_RABIT VAMRNVPDLSAGVSCAFEEVAESEAVLLPSGELRCASPSLQELQALTRGHGATRTVRLQL B1MTV7_CALMO B1MTV7_CALMO VALHNVPDLSAGVSCAFEEAAESEAVLLPSGELRCPSPSLQELRALTRGHGATRAVRLQL A9CB66_PAPAN A9CB66_PAPAN VALHNVPDLSAGVSCTFEEVAESEAILLPSGELLCPSPSLQELRALTRGHGATRTVRLQL PLXA3_HUMAN PLXA3_HUMAN VTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQELRALTRGHGATRTVRLQL Q4T5C4_TETNG Q4T5C4_TETNG IRVENVPALSGGVSCVFEDLSETPGEVRPKGQVVCMSPSLRELPVQMQSPAEQRVVQLSL A5JJU2_DANRE A5JJU2_DANRE VKVANVPNLSAGVTCVFEELTESPGEVLAEGQILCMSPSLRDVPSVTQGYGDKRVVKLSL B0S5N4_DANRE B0S5N4_DANRE VKVANVPNLSAGVTCVFEELTESPGEVLAEGQILCMSPSLRDVPSVTQGYGDKRVVKLSL B3DKK4_DANRE B3DKK4_DANRE VKVANVPNLSAGVTCVFEELTESPGEVLAKGQILCMSPSLRDVPSVTQGYGDKRVVKLSL A8IYK6_DANRE A8IYK6_DANRE VKVANVPNLSAGVTCVFEELTESPGEVLAKGQILCMSPSLRDVPSVTQGYGDKRVVKLSL Q4S650_TETNG Q4S650_TETNG LRVSHVPDLSAGITCSFGNLTEVEGQV-NGNQILCVSPAAKDVPLIPTDQ-DWSGVELQL B1WB12_XENTR B1WB12_XENTR LKVSNVPDLSAGVTCAFGDLKQEEGQVQSGSRIDCVSPAAKDIPTMLAAQ-DWFGVELQL PLXA2_HUMAN PLXA2_HUMAN LVVSDAPDLSAGIACAFGNLTEVEGQV-SGSQVICISPGPKDVPVIPLDQ-DWFGLELQL PLXA2_MOUSE PLXA2_MOUSE LVVNDAPNLSEGIACAFGNLTEVEGQV-SGSQVICISPGPKDVPVIPLDQ-DWFGLELQL B3DK42_DANRE B3DK42_DANRE LEAHNVPELSAGVNCTFEDLAEMDGLV-EGNRITCSSPAEKEVPRIIVDQGDHQIVQLYL PLXA4_DANRE PLXA4_DANRE LEAHNVPELSAGVNCTFEDLAEMDGLV-EGNRITCSSPAEKEVPRIIVDQGDHQIVQLYL B7WNM6_HUMAN B7WNM6_HUMAN LETYNVPELSAGVNCTFEDLSEMDGLV-VGNQIQCYSPAAKEVPRIITENGDHHVVQLQL PLXA4_HUMAN PLXA4_HUMAN LETYNVPELSAGVNCTFEDLSEMDGLV-VGNQIQCYSPAAKEVPRIITENGDHHVVQLQL B9EJ29_MOUSE B9EJ29_MOUSE LETYNVPELSAGVNCTFEDLSEMDGLV-IGNQIQCYSPAAKEVPRIITENGDHHVVQLQL PLXA4_MOUSE PLXA4_MOUSE LETYNVPELSAGVNCTFEDLSEMDGLV-IGNQIQCYSPAAKEVPRIITENGDHHVVQLQL MATCH : ..* ** *: * * : . : ..: * ** ::: :.* * CONSENSUS ????NVP?LSAGV?C?FE???E????????????C?SP?????????????????V?L?L

A8IYK2_DANRE A8IYK2_DANRE KSRETGQKFASVDFTFYNCSIHRSCLSCVNGSFPCHWCKYRHLCTQNANDCSFQEGRVNM Q5U5A2_XENLA Q5U5A2_XENLA KSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNAADCSFQEGRVNM A2RUV3_XENTR A2RUV3_XENTR KSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNAADCSFQEGRVNM Q91823_XENLA Q91823_XENLA KSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNAADCSFQEGRVNM PLXA1_HUMAN PLXA1_HUMAN KSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNVADCAFLEGRVNV PLXA1_MOUSE PLXA1_MOUSE KSKETGKKFASVDFVFYNCSVHQSCLACVNGSFPCHWCKYRHVCTNNAADCAFLEGRVNM A5D6Q5_MOUSE A5D6Q5_MOUSE LSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHS P70208_MOUSE P70208_MOUSE LSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHS B5FW97_OTOGA B5FW97_OTOGA LSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHS B2KIK2_RHIFE B2KIK2_RHIFE LSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHS B7NZQ8_RABIT B7NZQ8_RABIT LSKETGVRFAGADFVFYNCSVLQSCMSCVGSAYPCHWCKYRHVCTSHPHECSFQEGRVHS B1MTV7_CALMO B1MTV7_CALMO RSKETGVRFAGADFVFYNCSVLQSCMSCVGSLYPCHWCKYRHVCTSRPHECSFQEGRVHS A9CB66_PAPAN A9CB66_PAPAN LSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHACTSRPHECSFQEGRVRS PLXA3_HUMAN PLXA3_HUMAN LSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEGRVHS Q4T5C4_TETNG Q4T5C4_TETNG RSTETGHQFISTSFVYYNCSVLNSCTSCVSSVFPCHWCKYRHICTNNLQDCSFQEGRVSG A5JJU2_DANRE A5JJU2_DANRE KSKETGLKFITTDFVFYNCSVLQSCSSCVSSSFPCNWCKYRHICTNNVAECSFQEGRVSS B0S5N4_DANRE B0S5N4_DANRE KSKETGLKFITTDFVFYNCSVLQSCSSCVSSSFPCNWCKYRHICTNNVAECSFQEGRVSS B3DKK4_DANRE B3DKK4_DANRE KSKETGLKFITTDFVFYNCSVLQSCSSCVSSPFPCNWCKYRHICTNNVAECSFQEGRVSS A8IYK6_DANRE A8IYK6_DANRE KSKETGLKFITTDFVFYNCSVLQSCSSCVSSPFPCNWCKYRHICTNNVAECSFQEGRVSS Q4S650_TETNG Q4S650_TETNG NSKETGQMVISTEVKFYNCSVHQLCLSCVNSAFRCHWCKYRNLCTHDPSSCSFQEGRVNA B1WB12_XENTR B1WB12_XENTR ISKETGKTFVSTNFKFYNCSAHQHCLSCVNGDFRCHWCKYRNLCTHDPTSCSFQEGRVNV PLXA2_HUMAN PLXA2_HUMAN RSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINI PLXA2_MOUSE PLXA2_MOUSE RSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINV B3DK42_DANRE B3DK42_DANRE KSKETGLAFANTSFVFYNCSVHKSCLSCVGSPYQCHWCKYRHTCTHDPSSCSFQEGRVKQ PLXA4_DANRE PLXA4_DANRE KSKETGLAFANTSFVFYNCSVHKSCLSCVGSPYQCHWCKYRHTCTHDPSSCSFQEGRVKQ B7WNM6_HUMAN B7WNM6_HUMAN KSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHDPKTCSFQEGRVKL PLXA4_HUMAN PLXA4_HUMAN KSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHDPKTCSFQEGRVKL B9EJ29_MOUSE B9EJ29_MOUSE KSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHDPNTCSFQEGRVKL PLXA4_MOUSE PLXA4_MOUSE KSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHGRNTCSFQEGRVKL MATCH * *** . ... :**** . * :** . : *:*****: ** *:* ***: CONSENSUS ?SKETG??F????FVFYNCS???SC?SCV?????CHWCKYRH?CT?????CSFQEGRV??

A8IYK2_DANRE A8IYK2_DANRE SEDCPQILPSTEIYIPVGVPKPITLSARNLPQPQSGQRNYECVFHIQGETHSVTALRFNS Q5U5A2_XENLA Q5U5A2_XENLA SEDCPQILPSSQIYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNS A2RUV3_XENTR A2RUV3_XENTR SEDCPQILPSTQIYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNS Q91823_XENLA Q91823_XENLA SEDCPQILPSSQIYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNS PLXA1_HUMAN PLXA1_HUMAN SEDCPQILPSTQIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNS PLXA1_MOUSE PLXA1_MOUSE SEDCPQILPSTHIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNS A5D6Q5_MOUSE A5D6Q5_MOUSE PEGCPEILPQGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNS P70208_MOUSE P70208_MOUSE PEGCPEILPQGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNS B5FW97_OTOGA B5FW97_OTOGA PEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVWGRQQRVPAVRFNS B2KIK2_RHIFE B2KIK2_RHIFE PEGCPEILPIGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNS B7NZQ8_RABIT B7NZQ8_RABIT PEGCPELLPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVLRVQGRQQRVPAVRFNS B1MTV7_CALMO B1MTV7_CALMO SEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNS A9CB66_PAPAN A9CB66_PAPAN PEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNS PLXA3_HUMAN PLXA3_HUMAN PEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNS Q4T5C4_TETNG Q4T5C4_TETNG MEGCPQIVPTSDILVPAEWVRPITLRARNLPQPQSGQKNYECVFNIQGKVQRIPAVRFNS A5JJU2_DANRE A5JJU2_DANRE AEGCPQILPSSDILVPAGIVRPITLRARNLPQPQSGQKNYECVFNIQGKVQRIPAVRFNS B0S5N4_DANRE B0S5N4_DANRE AEGCPQILPSSDILVPAGIVRPITLRARNLPQPQSGQKNYECVFNIQGKVQRIPAVRFNS B3DKK4_DANRE B3DKK4_DANRE AEGCPQILPSSDILVPAGIVRPITLRARNLPQPQSGQKNYECVFNIQGKVQRIPAVRFNS A8IYK6_DANRE A8IYK6_DANRE AEGCPQILPSSDILVPAGIVRPITLRARNLPQPQSGQKNYECVFNIQGKVQRIPAVRFNS Q4S650_TETNG Q4S650_TETNG SEDCPQLVRSEEILIPAGEVKPITLKAKNLPQPQSGQRGYECVLHIQGVSHRVTALRFNS B1WB12_XENTR B1WB12_XENTR SEDCPQLVPSEEILIPVGEVRPITLKARNLPQPQSGQRGYECVLNIQGVVHRMPALRFNS PLXA2_HUMAN PLXA2_HUMAN SEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNS PLXA2_MOUSE PLXA2_MOUSE SEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNS B3DK42_DANRE B3DK42_DANRE PEECPQLLPADRILVPVNVVKPITLRAKNLPQPQSGQRGYECVLTIQGVEQRVPALRFNS PLXA4_DANRE PLXA4_DANRE PEECPQLLPADRILVPVNVVKPITLRAKNLPQPQSGQRGYECVLTIQGVEQRVPALRFNS B7WNM6_HUMAN B7WNM6_HUMAN PEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNS PLXA4_HUMAN PLXA4_HUMAN PEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNS B9EJ29_MOUSE B9EJ29_MOUSE PEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGIEQRVPALRFNS PLXA4_MOUSE PLXA4_MOUSE PEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGIEQRVPALRFNS MATCH * **::: : :*. :*:** *:*********:.***:. : * :.*:**** CONSENSUS ?E?CP??LP??????P?????P?TL?A?NLPQPQSGQ??YEC?????G???R??A?RFNS

A8IYK2_DANRE A8IYK2_DANRE SSIQCQKTTYNYEGSDISDLPVDLSVVWNGNFIIDNPYNIQAHLYKCYALRESCGLCLKA Q5U5A2_XENLA Q5U5A2_XENLA TSIQCQNTSYNYEGNDVSDLPVNLSVVWNGHFVIDNPQNIQAHLYKCSALRESCGLCLKA A2RUV3_XENTR A2RUV3_XENTR TSIQCQNTSYNYEGNDISDLPVNLSVVWNGHFVIDNPQNIQAHLYKCSALRESCGLCLKS Q91823_XENLA Q91823_XENLA TSIQCQNTSYNYEGNDISDLPVNLSVVWNGHFVIDNPQNIQAHLYKCSALRESCGLCLKS PLXA1_HUMAN PLXA1_HUMAN SSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRESCGLCLKA PLXA1_MOUSE PLXA1_MOUSE SSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRQSCGLCLKA A5D6Q5_MOUSE A5D6Q5_MOUSE SSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKA P70208_MOUSE P70208_MOUSE SSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKA B5FW97_OTOGA B5FW97_OTOGA SSIQCQNASYSYEGDEYGDTELDFSVVWDGDFPIDKPPTFRALLYKCWAQRPNCGLCLKA B2KIK2_RHIFE B2KIK2_RHIFE SSVQCQNASYSYEGDEYGDTELDFSVVWDGDFPIDKPATFRALLYKCWAQRPSCGLCLKA B7NZQ8_RABIT B7NZQ8_RABIT SSVQCQNASYSYEGDEYGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRASCGLCLKA B1MTV7_CALMO B1MTV7_CALMO SSVQCQNASYSYEGDEYGDAELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKA A9CB66_PAPAN A9CB66_PAPAN SSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKA PLXA3_HUMAN PLXA3_HUMAN SSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKA Q4T5C4_TETNG Q4T5C4_TETNG SCIQCQNTSYWYEGDEAGDLPVDFSIVWDGDFFIDKPTSMKALLYKCEAQRSSCGQCLKA A5JJU2_DANRE A5JJU2_DANRE SCIQCQNTSYWYEGNEMGDLPVDFSIVWDGDFPIDKPSSMRALLYKCEAQRDSCGLCLKA B0S5N4_DANRE B0S5N4_DANRE SCIQCQNTSYWYEGNEMGDLPVDFSIVWDGDFPIDKPSSMRALLYKCEAQRDSCGLCLKA B3DKK4_DANRE B3DKK4_DANRE SCIQCQNTSYWYEGNEMGDLPVDFSIVWDGDFPIDKPSSMRALLYKCEAQRDSCGLCLKA A8IYK6_DANRE A8IYK6_DANRE SCIQCQNTSYWYEGNEMGDLPVDFSIVWDGDFPIDKPSSMRALLYKCEAQRDSCGLCLKA Q4S650_TETNG Q4S650_TETNG SSVQCQNSSYLYEGMKISELPVDFSVVWNGNFIIDNPENIRVHLYKCAAQRDSCGMCLKA B1WB12_XENTR B1WB12_XENTR SSVQCQNSSYIYEGMDVSDLPVDFSVVWNGNFTIDNPQLIKVHLYKCAALRESCGLCLKA PLXA2_HUMAN PLXA2_HUMAN SSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKA PLXA2_MOUSE PLXA2_MOUSE SSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKA B3DK42_DANRE B3DK42_DANRE SSVQCQNTSYMYDGMEMSSLPVDLTVIWNGDFSIDNPAQNKVHLYKCDARRESCGLCLKA PLXA4_DANRE PLXA4_DANRE SSVQCQNTSYMYDGMEMSSLPVDLTVIWNGDFSIDNPAQNKVHLYKCDARRESCGLCLKA B7WNM6_HUMAN B7WNM6_HUMAN SSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCGAMRESCGLCLKA PLXA4_HUMAN PLXA4_HUMAN SSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCGAMRESCGLCLKA B9EJ29_MOUSE B9EJ29_MOUSE SSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVYLYKCGAMRESCGLCLKA PLXA4_MOUSE PLXA4_MOUSE SSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVYLYKCGAMRESCGLCLKA MATCH :.:***:::* *:* . .. ::::::*:*.* **:* :. **** * * .** ***: CONSENSUS SS?QCQN?SY?YEG???????????VVW?G?F?ID?P??????LYKC?A?R?SCGLCLKA

A8IYK2_DANRE A8IYK2_DANRE DPSFECGWCVQDRKCSLRQECA--QP-ENTWMHATAGNSRCTHPRITKLSPETGPRQGGT Q5U5A2_XENLA Q5U5A2_XENLA DRSFECGWCVSEKKCTLRQNCP--IL-ENPWMHASTTNSRCTDPKITKLFPETGPRQGGT A2RUV3_XENTR A2RUV3_XENTR DRRFECGWCVSEKKCTLRQNCP--AY-ENPWMHASTVNSRCTDPKITKLFPETGPKQGGT Q91823_XENLA Q91823_XENLA DRRFECGWCVSEKKCTLRQNCP--TL-ENPWMHASTANSRCTDPKITKLFPETGPRQGGT PLXA1_HUMAN PLXA1_HUMAN DPRFECGWCVAERRCSLRHHCA--ADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGT PLXA1_MOUSE PLXA1_MOUSE DPRFECGWCVAERRCSLRHHCP--ADSPASWMHAHHGSSRCTDPKILKLSPETGPRQGGT A5D6Q5_MOUSE A5D6Q5_MOUSE DPRFNCGWCISEHRCQLRAHCP--AP-KSNWMHPSQKGARCSHPRITQIHPLTGPKEGGT P70208_MOUSE P70208_MOUSE DPRFNCGWCISEHRCQLRAHCP--AP-KSNWMHPSQKGARCSHPRITQIHPLTGPKEGGT B5FW97_OTOGA B5FW97_OTOGA DPRFSCGWCISEHRCQLRAHCP--AP-KTNWIHPSQKGARCSHPRITQIHPLMGPKEGGT B2KIK2_RHIFE B2KIK2_RHIFE DPRFNCGWCVSEHRCQLRAHCP--AP-KTNWMHPSQKGTRCSHPRIAQIYPLMGPKEGGT B7NZQ8_RABIT B7NZQ8_RABIT DPRFNCGWCISEHRCQLRAHCP--AP-KTNWMHPSQKGARCSHPRIAQIHPLMGPKEGGT B1MTV7_CALMO B1MTV7_CALMO DPRFSCGWCISEHRCQLRTHCP--AP-KTNWMHPSQKGTRCSHPRITQIHPLVGPKEGGT A9CB66_PAPAN A9CB66_PAPAN DPRFNCGWCISEHRCQLRTHCP--AP-KTNWMHLSQKGTRCSHPHITQIHPLVGPKEGGT PLXA3_HUMAN PLXA3_HUMAN DPRFNCGWCISEHRCQLRTHCP--AP-KTNWMHLSQKGTRCSHPRITQIHPLVGPKEGGT Q4T5C4_TETNG Q4T5C4_TETNG PPAFECGWCVETRKCLLRQHCP--TP-EQNWMHHGRHNLRCSHPRITKISPLTGPREGGT A5JJU2_DANRE A5JJU2_DANRE DSTFECGWCLADKKCLLKQHCP--SA-EHNWMHQGRRNIRCSHPRITKIRPLTGPKEGGT B0S5N4_DANRE B0S5N4_DANRE DSTFECGWCLADKKCLLKQHCP--SA-EHNWMHQGRRNIRCSHPRITKIRPLTGPKEGGT B3DKK4_DANRE B3DKK4_DANRE DSTFECGWCLADKKCLLKQHCP--SA-EHNWMHQGRRNIRCSHPRITKIRPLTGPKEGGT A8IYK6_DANRE A8IYK6_DANRE DSTFECGWCLADKKCLLKQHCP--SA-EHNWMHQGRRNIRCSHPRITKIRPLTGPKEGGT Q4S650_TETNG Q4S650_TETNG ERKFQCGWCSGEGRCTLRHHCPPVNPYTSRWLNLSSKNVKCTNPRITEVTPVAGPPEGGT B1WB12_XENTR B1WB12_XENTR DHKYECGWCNGEGRCTLHHHCM--SP-QNQWLDWSSRNVKCINPRIHEILTVSGPPEGGT PLXA2_HUMAN PLXA2_HUMAN DRKFECGWCSGERRCTLHQHCT--SP-SSPWLDWSSHNVKCSNPQITEILTVSGPPEGGT PLXA2_MOUSE PLXA2_MOUSE DHKFECGWCSGERRCTLHQHCP--ST-SSPWLDWSSHNVKCSNPQITEILTVSGPPEGGT B3DK42_DANRE B3DK42_DANRE DPLFGCVWCKGENRCSLKQHCS--YP-QSMWLEHNGINSKCTHPRITKITPLRGPREGGT PLXA4_DANRE PLXA4_DANRE DPLFGCVWCKGENRCSLKQHCS--YP-QSMWLEHNGINSKCTHPRITKITPLRGPREGGT B7WNM6_HUMAN B7WNM6_HUMAN DPDFACGWCQGPGQCTLRQHCP--AQ-ESQWLELSGAKSKCTNPRITEIIPVTGPREGGT PLXA4_HUMAN PLXA4_HUMAN DPDFACGWCQGPGQCTLRQHCP--AQ-ESQWLELSGAKSKCTNPRITEIIPVTGPREGGT B9EJ29_MOUSE B9EJ29_MOUSE DPDFECGWCQSPGQCTLRQHCP--AH-ESRWLELSGANSKCTNPRITEIIPVTGPREGGT PLXA4_MOUSE PLXA4_MOUSE DPDFECGWCQSPGQCTLRQHCP--AH-ESRWLELSGANSKCTNPRITEIIPVTGPREGGT MATCH : * ** :* *: .* *:. :* .*:* :: . ** :*** CONSENSUS D??F?CGWC?????C?L??HC?????????W?????????C??P?IT???P??GP??GGT

A8IYK2_DANRE A8IYK2_DANRE RLTISGENLGLQFKDIQNGVRIGKVSCQPIEEEYISAEQIVCRLADATGYRVQEAHVEVC Q5U5A2_XENLA Q5U5A2_XENLA RLTITGENLGLRFEDIHIGVKVGQVVCVPIESEYISAEQIVCEINDAGRTRVHEAQVEVC A2RUV3_XENTR A2RUV3_XENTR LLTITGENLGLRFEDIRFGVRVGHVMCVPIENEYISAEQIVCEIKDAGKMRVHEAQVEVC Q91823_XENLA Q91823_XENLA RLTITGENLGLRFEDIRFGVRVGHVMCVPVESEYISAEQIVCEINDAGRTRVHEAQVEVC PLXA1_HUMAN PLXA1_HUMAN RLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVC PLXA1_MOUSE PLXA1_MOUSE RLTITGENLGLRFEDVRLGVHVGKVLCSPVESEYISAEQIVCEIGDASTLRAHDALVEVC A5D6Q5_MOUSE A5D6Q5_MOUSE RVTIVGENLGLTSREV--GLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELC P70208_MOUSE P70208_MOUSE RVTIVGENLGLTSREV--GLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELC B5FW97_OTOGA B5FW97_OTOGA QVTILGENLGLASREL--GLRVAGVRCNSIPAEYVSAERIVCEMEESLVPSPLPGPVELC B2KIK2_RHIFE B2KIK2_RHIFE RVTIVGENLGLTYREV--GLRVAGVRCNSIATEYVSAERIVCEMEESLVPSPPPGPVELC B7NZQ8_RABIT B7NZQ8_RABIT RVTIVGENLGLASREV--GLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELC B1MTV7_CALMO B1MTV7_CALMO WVTIVGENLGLLSREV--GLRVAGVRCNSIPAEYVSAERIVCEMEESLVPSPPPGPVELC A9CB66_PAPAN A9CB66_PAPAN RVTIMGENLGLLSREV--GLRVAGVRCNSIPAEYISAERIVCEMEESLVPSPPPGPVELC PLXA3_HUMAN PLXA3_HUMAN RVTIVGDNLGLLSREV--GLRVAGVRCNSIPAEYISAERIVCEMEESLVPSPPPGPVELC Q4T5C4_TETNG Q4T5C4_TETNG RVTIEGENLGLQVKEIA-YVQVAGVRCSSVPSQYVSAERVVCDMAEALLPHSPGGPVELC A5JJU2_DANRE A5JJU2_DANRE RVTIEGENLGLQVREIT-HVRVAGVRCNPAAAEYISAERIVCDMEESLMSSPPGGPVELC B0S5N4_DANRE B0S5N4_DANRE RVTIEGENLGLQVREIT-HVRVAGVRCNPAAAEYISAERIVCDMEESLMSSPPGGPVELC B3DKK4_DANRE B3DKK4_DANRE RVTIEGENLGLQVREIT-HVRVAGVRCNPAAAEYISAERIVCDMEESLMSSPPGGPVELC A8IYK6_DANRE A8IYK6_DANRE RVTIEGENLGLQVREIT-HVRVAGVRCNPAAAEYISAERIVCDMEESLMSSPPGGPVELC Q4S650_TETNG Q4S650_TETNG RVTIHGTNLGLAFSDMVGNVEVAGVRCTPVEDGYIIAEQIVCEMDPA-ALDIRPGPAQLC B1WB12_XENTR B1WB12_XENTR RVTIRGANLGLNFSEIAQNVVVAGVQCTPVEEEYIIAEQIVCEMGQA-SPTSSSGPVLLC PLXA2_HUMAN PLXA2_HUMAN RVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHA-LVGTTSGPVRLC PLXA2_MOUSE PLXA2_MOUSE RVTIHGVNLGLDFSEIAHHVQVAGVPCTPIPGEYIIAEQIVCEMGHA-VIGTTSGPVRLC B3DK42_DANRE B3DK42_DANRE LVTIRGENLGLEFSEIKDHVKVADVECTPVPEGYIPAEQIVCEMGKA-ERSQFAGNVQVC PLXA4_DANRE PLXA4_DANRE LVTIRGENLGLEFSEIKDHVKVADVECTPVPEGYIPAEQIVCEMGKA-ERSQFAGNVQVC B7WNM6_HUMAN B7WNM6_HUMAN KVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEA-KPSQHAGFVEIC PLXA4_HUMAN PLXA4_HUMAN KVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEA-KPSQHAGFVEIC B9EJ29_MOUSE B9EJ29_MOUSE KVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEA-KPSQHAGFVEIC PLXA4_MOUSE PLXA4_MOUSE KVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEA-KPSQHAGFVEIC MATCH :** * **** :: : :. * * . *: **::** : : . . :* CONSENSUS ??TI?GENLGL??????????V??V?C??????Y??AE?IVC??????????????V??C

A8IYK2_DANRE A8IYK2_DANRE VRDCLQDYRAVSPKVFTFVSPYFTRVVPSYGPISGGTRITIYGSHLNAGSAVSIKIGLNT Q5U5A2_XENLA Q5U5A2_XENLA VKDCSQDYRAISPKSFTFVVPSFNRVTPSRGPLSGGTWISIEGNYLNAGSDVSVYIGGRS A2RUV3_XENTR A2RUV3_XENTR VKDCSQDYRAISPKSFTFVVPSFNRVTPSRGPLSGGTWISIEGSYLNSGSDVSVDIGGRP Q91823_XENLA Q91823_XENLA VKDCSQDYRAISPKSFTFVLPSFNRVTPSRGPLSGGTWISIEGNYLNAGSDVSVAIGGRP PLXA1_HUMAN PLXA1_HUMAN VRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVGGRP PLXA1_MOUSE PLXA1_MOUSE VRDCSLHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSIGGRP A5D6Q5_MOUSE A5D6Q5_MOUSE VGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGE P70208_MOUSE P70208_MOUSE VGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGE B5FW97_OTOGA B5FW97_OTOGA IGDCSADFRTQSEQLYSFVSPMFDRVSPSRGPASGGSRLTIFGSSLDAGSRVTVTVRDGE B2KIK2_RHIFE B2KIK2_RHIFE VGDCSADFRTQSEQLYSFVTPMFDRVSPSRGPASGGTRLTISGSSLDAGSTVTVTVRDGE B7NZQ8_RABIT B7NZQ8_RABIT VGDCSADFRTQSEQLYSFVTPTFDRVSPSRGPASGGTRLTISGSSLNAGSRVTVTVRDGE B1MTV7_CALMO B1MTV7_CALMO VGDCSADFRAQSEQLYSFVTPTFDRVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDGE A9CB66_PAPAN A9CB66_PAPAN VGDCSADFRTQSEQLYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDSE PLXA3_HUMAN PLXA3_HUMAN VGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDSE Q4T5C4_TETNG Q4T5C4_TETNG IGVCSAEFRTLSSQTYSFVSPSFSRVHPEKGPVSGGTRLTVTGRHLDAGSSVSCIINKEE A5JJU2_DANRE A5JJU2_DANRE IGDCSAEYRTQSTQTYSFVMPSFSRVRPEKGPVSGGTRLTISGRHLDAGSAVTVFLAQEE B0S5N4_DANRE B0S5N4_DANRE IGDCSAEYRTQSTQTYSFVMPSFSRVRPEKGPVSGGTRLTISGRHLDAGSAVTVFLAQEE B3DKK4_DANRE B3DKK4_DANRE IGDCSAEYRTQSTQTYSFVMPSFSRVRPEKGPVSGGTRLTISGRHLDAGSAVTVFLAQEE A8IYK6_DANRE A8IYK6_DANRE IGDCSAEYRTQSTQTYSFVMPSFSRVRPEKGPVSGGTRLTISGRHLDAGSAVTVFLAQEE Q4S650_TETNG Q4S650_TETNG VGECRPELKARSSQLYSFVTPTVTGLSPHRGPESGGTKVTIMGENLGAGSSVTVLFGNQT B1WB12_XENTR B1WB12_XENTR IEECKPEFMARSLQQYTFVSPTVAHLSPSRGPESGGTMITITGHNLAAGSIVSVTLGNQT PLXA2_HUMAN PLXA2_HUMAN IGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQT PLXA2_MOUSE PLXA2_MOUSE IGECKPEFMTKSHQQYTFVNPSVLSLSPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQT B3DK42_DANRE B3DK42_DANRE VGECRPEFMAKSSKYYYFVIPQLLSLKPSRGPISGGTIVNITGGNLDAGSNVSIMFKDQK PLXA4_DANRE PLXA4_DANRE VGECRPEFMAKSSKYYYFVIPQLLSLKPSRGPISGGTIVNITGGNLDAGSNVSIMFKDQK B7WNM6_HUMAN B7WNM6_HUMAN VAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQP PLXA4_HUMAN PLXA4_HUMAN VAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQP B9EJ29_MOUSE B9EJ29_MOUSE VAVCRPEFMARSSQLYYFMTLTLADLKPNRGPMSGGTQVTITGTNLNAGSNVVVMFGSQP PLXA4_MOUSE PLXA4_MOUSE VAVCRPEFMARSSQLYYFMTLTLADLKPNRGPMSGGTQVTITGTNLNAGSNVVVMFGSQP MATCH : * . : * : : *: . : * ** ***: : : * * :** * . CONSENSUS ???C???????S?????FV?P??????P??GP?SGGT???I?G??L?AGS?V?V??????

A8IYK2_DANRE A8IYK2_DANRE CQFERRSAREIVCVTPAG-LGSGGTPVMVDINAAELRNPEVKFNYTDDPTILKIEPDWSI Q5U5A2_XENLA Q5U5A2_XENLA CMFSWRTAKEIRCKTPQG-PSTGKAEIQIHINRATLYNSEVHYNYTEDPTVQKIEPEWSI A2RUV3_XENTR A2RUV3_XENTR CMFSWRTAKEIRCKTPQG-PSTGKAEIQIHINRATLYNSEVHYNYTEDPTVQKIEPEWSI Q91823_XENLA Q91823_XENLA CMFSWRTAKEIRCKTPQG-PSTGKAEIQILINRATMNNSEVHYNYTEDPTVQKIEPEWSI PLXA1_HUMAN PLXA1_HUMAN CSFSWRNSREIRCLTPPG-QSPGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSI PLXA1_MOUSE PLXA1_MOUSE CSFSWRNSREIRCLTPPG-HTPGSAPIVININRAQLSNPEVKYNYTEDPTILRIDPEWSI A5D6Q5_MOUSE A5D6Q5_MOUSE CQFVRRDAEAIVCISPVSTLGPSQSPITLAIDHANISNTGVIYTYTQDPTVTHLEPTWSI P70208_MOUSE P70208_MOUSE CQFVRRDAEAIVCISPVSTLGPSQSPITLAIDHANISNTGVIYTYTQDPTVTHLEPTWSI B5FW97_OTOGA B5FW97_OTOGA CQFVRRDAEAIVCITPVSTLGPSQAPITLAIDRANVSSPGVIYTYTQDPTVTHLEPTWSI B2KIK2_RHIFE B2KIK2_RHIFE CQFVRRDAEAIVCISPISTLGPSQAPISLAIDRANISSPGVLYTYTQDPTVTRLEPTWSI B7NZQ8_RABIT B7NZQ8_RABIT CQFVRRDAEAIVCISPGSTQGPSQAPITLAIDRANISSPGVIYTYTQDPTVTRLEPTWSI B1MTV7_CALMO B1MTV7_CALMO CQFVRRDAQAIVCLSPVSTLGPSQAPITLAIDRANISSPGVIYTYTQDPTVTRLEPTWSI A9CB66_PAPAN A9CB66_PAPAN CQFVRRDAKAIVCISPVSTLGPSQAPITLAIDRANISSPGVLYTYTQDPTVTRLEPTWSI PLXA3_HUMAN PLXA3_HUMAN CQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEPTWSI Q4T5C4_TETNG Q4T5C4_TETNG CLFVKRTNREIICITPASLSGSGPASIRLMIDKAEVTSSETKYVYTEDPTITSIEPNWTI A5JJU2_DANRE A5JJU2_DANRE CLFVRRTVREIVCVTPPSASGSGPSSVKLFIDKAEIT-SDTRYIYTEDPNISTIEPNWSI B0S5N4_DANRE B0S5N4_DANRE CLFVRRTVREIVCVTPPSASGSGPSSVKLFIDKAEIT-SDTRYIYTEDPNISTIEPNWSI B3DKK4_DANRE B3DKK4_DANRE CLFVRRTVREIVCVTPPSASGSGPSSVKLFIDKAEIT-SDTRYIYTEDPNISTIEPNWSI A8IYK6_DANRE A8IYK6_DANRE CLFVRRTVREIVCVTPPSASGSGPSSVKLFIDKAEIT-SDTRYIYTEDPNISTIEPNWSI Q4S650_TETNG Q4S650_TETNG CEFFGRTMTEIVCYSAPSLSGVGPVQISVSVDRAQIR-ESLSFEYIEDPTIQRIEPDWSI B1WB12_XENTR B1WB12_XENTR CEYYGRSLNEIVCVTAPSTHGLGPVHVSVSVDRAQLE-SNLQFEYIDDPKVLRIEPEWSI PLXA2_HUMAN PLXA2_HUMAN CEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVD-SNLQFEYIDDPRVQRIEPEWSI PLXA2_MOUSE PLXA2_MOUSE CEFYGRSMNEIVCVSPPSSNGLGPVPVSVSVDRARVD-SSLQFEYIDDPRVQRIEPEWSI B3DK42_DANRE B3DK42_DANRE CTYQRRGGQWITCRSHASMQGYGNVSVSVYVDKAHIH-KDLKFEYVEDPTITKLEPEWSI PLXA4_DANRE PLXA4_DANRE CTYQRRGGQWITCRSHASMQGYGNVSVSVYVDKAHIH-KDLKFEYVEDPTITKLEPEWSI B7WNM6_HUMAN B7WNM6_HUMAN CLFHRRSPSYIVCNTTSS-DEVLEMKVSVQVDRAKIH-QDLVFQYVEDPTIVRIEPEWSI PLXA4_HUMAN PLXA4_HUMAN CLFHRRSPSYIVCNTTSS-DEVLEMKVSVQVDRAKIH-QDLVFQYVEDPTIVRIEPEWSI B9EJ29_MOUSE B9EJ29_MOUSE CLFHRRSPSYIICNTTSS-EEVLDMKVTVQVDRARIR-QDLVFQYVEDPTIVRIEPEWSI PLXA4_MOUSE PLXA4_MOUSE CLFHRRSPSYIICNTTSS-EEVLDMKVTVQVDRARIR-QDLVFQYVEDPTIVRIEPEWSI MATCH * : * * * : . : : :: * : : * :** : ::* *:* CONSENSUS C?F??R????I?C????????????????????A??????????Y??DP?????EP?WSI

A8IYK2_DANRE A8IYK2_DANRE ASGGTPLTVTGVNLATVREPKMRAKYGTISSVN----------NCTVLNNTVMVCAVPSV Q5U5A2_XENLA Q5U5A2_XENLA ASGGTPLIVTGMNLATIKEPHIRAKYGDVEKEN----------NCTVYNDTTMVCLAPSV A2RUV3_XENTR A2RUV3_XENTR ASGGTPLIVTGLNLATIKEPKIRAKYGDAEREN----------NCTVYNDTTMVCLAPSV Q91823_XENLA Q91823_XENLA ASGGTPLIVTGMNLATIKEPKIRAKYGDVEKEN----------NCTLYNDTTMVCLAPSV PLXA1_HUMAN PLXA1_HUMAN NSGGTLLTVTGTNLATVREPRIRAKYGGIEREN----------GCLVYNDTTMVCRAPSV PLXA1_MOUSE PLXA1_MOUSE NSGGTLLTVTGTNLATVREPRIRAKYGGIEREN----------SCMVYNDTTMVCRAPSI A5D6Q5_MOUSE A5D6Q5_MOUSE INGSTSITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQ-------------- P70208_MOUSE P70208_MOUSE INGSTSITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQVINDTAMLCKAPGI B5FW97_OTOGA B5FW97_OTOGA INGSTAITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQVINDTAMLCKAPGI B2KIK2_RHIFE B2KIK2_RHIFE INGSTAITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQVINDTAMLCKAPGI B7NZQ8_RABIT B7NZQ8_RABIT INGSTAITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQVINDTAMLCKAPGI B1MTV7_CALMO B1MTV7_CALMO INGSTAITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQVINDTAMLCKAPGI A9CB66_PAPAN A9CB66_PAPAN INGSTAITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQVINDTAMLCKAPGI PLXA3_HUMAN PLXA3_HUMAN INGSTAITVSGTHLLTVQEPRVRAKYRGIETTN----------TCQVINDTAMLCKAPGI Q4T5C4_TETNG Q4T5C4_TETNG LNGSTMITVTGTNLLTIQEPKVRAKYGGVETSN----------FCTLVNDSTMTCLAPGL A5JJU2_DANRE A5JJU2_DANRE INGSTSLTVTGTNLLTIQEPKVRAKYGGVETTN----------ICSLVNDSVMTCLAPGI B0S5N4_DANRE B0S5N4_DANRE INGSTSLTVTGTNLLTIQEPKVRAKYGGVETTN----------ICSLVNDSVMTCLAPGI B3DKK4_DANRE B3DKK4_DANRE INGSTSLTVTGTNLLTIQEPKVRAKYGGVETTN----------ICSLVNDSVMTCLAPGI A8IYK6_DANRE A8IYK6_DANRE INGSTSLTVTGTNLLTIQEPKVRAKYGGVETTN----------ICSLVNDSVMTCLAPGI Q4S650_TETNG Q4S650_TETNG ASGHTPLMVTGTNLDVVQEPRIRVKYAGRESVNLKAQQVWRCEVCKVLNMTSMSCFAPSL B1WB12_XENTR B1WB12_XENTR ASGHTSLTVIGTNLDIIQQPRIRVKSNGKESVN----------VCKVVNATCLTCLAPAL PLXA2_HUMAN PLXA2_HUMAN ASGHTPLTITGFNLDVIQEPRIRVKFNGKESVN----------VCKVVNTTTLTCLAPSL PLXA2_MOUSE PLXA2_MOUSE TSGHTPLTITGFNLDVIQEPRVRVKFNGKESVN----------VCTVVNTTTLTCLAPSL B3DK42_DANRE B3DK42_DANRE FSGNTPLTVSGTNLDIIHTPLIRAKYKNLETIN----------ICQVLSPTTMQCMAPEL PLXA4_DANRE PLXA4_DANRE FSGNTPLTVSGTNLDIIHTPLIRAKYKNLETIN----------ICQVLSPTTMQCMAPEL B7WNM6_HUMAN B7WNM6_HUMAN VSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHIN----------ICEVLNATEMTCQAPAL PLXA4_HUMAN PLXA4_HUMAN VSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHIN----------ICEVLNATEMTCQAPAL B9EJ29_MOUSE B9EJ29_MOUSE VSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHIN----------ICEVLNATEMTCQAPAL PLXA4_MOUSE PLXA4_MOUSE VSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHIN----------ICEVLNATEMTCQAPAL MATCH .* * : : * :* :: * :*.* . * * CONSENSUS ??G?T???V?G??L?????P??RAK????E??N???????????C???N???M?C?AP??

A8IYK2_DANRE A8IYK2_DANRE AGSERGFSEVGNAPDEIGFIMDHVQMLLVVNES-FSFYPDPVFEAFGPA-MLELKPGSPL Q5U5A2_XENLA Q5U5A2_XENLA DNPLRNPPENGDRPDEIGFIMDNVHALLIVNTTNFLYYPDPVFEPLTASGNLELKPSSPL A2RUV3_XENTR A2RUV3_XENTR ENPLRSPPENGDRPDEIGFIMDNVLALLIVNTTSFLYYPDPVFEPLTASGNLELKPSSPL Q91823_XENLA Q91823_XENLA DNPLRSPPENGDRPDEIGFIMDNVHALLIVNTTSFLYYPDPVFEPLTASGNLELKPSSPL PLXA1_HUMAN PLXA1_HUMAN ANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVLEPLSPTGLLELKPSSPL PLXA1_MOUSE PLXA1_MOUSE DNPKRSPPELGERPDEIGFIMDNVRTLLVLNSSSFLYYPDPVLEPLSPTGLLELKPSSPL A5D6Q5_MOUSE A5D6Q5_MOUSE ------------------------------------------------------------ P70208_MOUSE P70208_MOUSE FLGHPQPRAQGEHPDEFGFLLDHVQAARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHV B5FW97_OTOGA B5FW97_OTOGA FLGRPQPRAQGEHPDEFGFVLDHVQTARSLNRSSFTYYPDPSFEPLGPFGVLDVKPGSHV B2KIK2_RHIFE B2KIK2_RHIFE FLGRPQPQAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHV B7NZQ8_RABIT B7NZQ8_RABIT FLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHV B1MTV7_CALMO B1MTV7_CALMO FLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHV A9CB66_PAPAN A9CB66_PAPAN FLGQPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHV PLXA3_HUMAN PLXA3_HUMAN FLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHV Q4T5C4_TETNG Q4T5C4_TETNG VYNKLAPPEGALHPEEFGFIFDQVSSLLVLNSTPFTHYPNPIFDPLGSSGILEVKPGSPI A5JJU2_DANRE A5JJU2_DANRE IYTKREAPESGVHPDEFGFILDHVSALLILNGTPFTYYPNPTFEPLGNAGILEVKPGSPI B0S5N4_DANRE B0S5N4_DANRE IYTKREAPESGVHPDEFGFILDHVSALLILNGTPFTYYPNPTFEPLGNAGILEVKPGSPI B3DKK4_DANRE B3DKK4_DANRE IYTKREAPESGVHPDEFGFILDHVSALLILNGTPFTYYPNPTFEPLGNAGILEVKPGSPI A8IYK6_DANRE A8IYK6_DANRE IYTKREAPESGVHPDEFGFILDHVSALLILNGTPFTYYPNPTFEPLGNAGILEVKPGSPI Q4S650_TETNG Q4S650_TETNG TVEYHPGLDTVKHADEFGFIFNNVQALLVYNNTNLLYYPNPYFEPLSSSGVLEQKPGSPI B1WB12_XENTR B1WB12_XENTR TLEYRPGLDSVERPNEFGFIFNNVQSLLVFNNTKFIYYPNPTFELLSPNGVLEQKPGSPI PLXA2_HUMAN PLXA2_HUMAN TTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPI PLXA2_MOUSE PLXA2_MOUSE TSDYRPGLDTVERPDEFGFLFNNVQSLLIYNDTKFIYYPNPTFELLSPTGILDQKPGSPI B3DK42_DANRE B3DK42_DANRE PYSISKHKDVPERPDEFGFILDNVQSVLALNNTNFVYYPNPVFEPLSVSGVQELKPGSPI PLXA4_DANRE PLXA4_DANRE PYSISKHKDVPERPDEFGFILDNVQSVLALNNTNFVYYPNPVFEPLSVSGVQELKPGSPI B7WNM6_HUMAN B7WNM6_HUMAN ALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPI PLXA4_HUMAN PLXA4_HUMAN ALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPI B9EJ29_MOUSE B9EJ29_MOUSE ALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAFSPSGILELKPGTPI PLXA4_MOUSE PLXA4_MOUSE ALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAFSPSGILELKPGTPI MATCH CONSENSUS ?????????????P?E?GF??D?V??????N???F?YYP?P?FE?????G?L??KP?S??

A8IYK2_DANRE A8IYK2_DANRE ILKGKNLIPSAA-GNYRLNYTVLIGDKQCVLTVSETQLLCESPNLTGQHKVTVLAGGFRF Q5U5A2_XENLA Q5U5A2_XENLA IIKGRNLIPAAP-GNFRLNYTVLIGDTPCALTVSETQLLCESPNLTGQHKVTIKAGGFEY A2RUV3_XENTR A2RUV3_XENTR IIKGRNLIPAAP-GNFRLNYTVLIGDTPCALTVSETQLLCESPNLTGQHKVTIKAGGFEY Q91823_XENLA Q91823_XENLA IIKGRNLIPAAP-GNFRLNYTVLIGDTPCALTVSETQLLCESPNLTGQHKVTIKAGGFEY PLXA1_HUMAN PLXA1_HUMAN ILKGRNLLPPAP-GNSRLNYTVLIGSTPCTLTVSETQLLCEAPNLTGQHKVTVRAGGFEF PLXA1_MOUSE PLXA1_MOUSE ILKGRNLLPPAP-GNSRLNYTVLIGSTPCILTVSETQLLCEAPNLTGQHKVTVRAGGFEF A5D6Q5_MOUSE A5D6Q5_MOUSE ---GKNLIPAAA-GSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEF P70208_MOUSE P70208_MOUSE VLKGKNLIPAAA-GSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEF B5FW97_OTOGA B5FW97_OTOGA VLKGKNLIPAAA-GSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEF B2KIK2_RHIFE B2KIK2_RHIFE VLKGKNLIPAAA-GSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEF B7NZQ8_RABIT B7NZQ8_RABIT VLKGKNLIPAAA-GSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEF B1MTV7_CALMO B1MTV7_CALMO VLKGKNLIPAAA-GSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEF A9CB66_PAPAN A9CB66_PAPAN VLKGKNLIPAAA-GSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEF PLXA3_HUMAN PLXA3_HUMAN VLKGKNLIPAAA-GSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGGLEF Q4T5C4_TETNG Q4T5C4_TETNG ILKGKNLIPPAP-GNGRLNYTVLIGESPCLLTVSENQLLCDSPDLTGEQRVLILVGGLEY A5JJU2_DANRE A5JJU2_DANRE ILKGKNLIPPAP-GNIRLNYSVTIGETPCLLTVSESQLLCDSPDLTGEQRVMILVGGLEY B0S5N4_DANRE B0S5N4_DANRE ILKGKNLIPPAP-GNIRLNYSVTIGETPCLLTVSESQLLCDSPDLTGEQRVMILVGGLEY B3DKK4_DANRE B3DKK4_DANRE ILKGKNLIPPVP-GNIRLNYSVTIGETPCLLTVSESQLLCDSPDLTGEQRVMILVGGLEY A8IYK6_DANRE A8IYK6_DANRE ILKGKNLIPPAP-GNIRLNYSVTIGETPCLLTVSESQLLCDSPDLTGEQRVMILVGGLEY Q4S650_TETNG Q4S650_TETNG ILKGRNLFPQRL-EGFR-----------SAVSTSLRGLSTSCPT---------------- B1WB12_XENTR B1WB12_XENTR ILKGRNLCPPAT-GGAKLSYTVLIGKTPCAVTVSETQLLCESPNLTGQHKVTVYVGGMVF PLXA2_HUMAN PLXA2_HUMAN ILKGKNLCPPAS-GGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVF PLXA2_MOUSE PLXA2_MOUSE ILKGKNLCPPAS-GGAKLNYTVMIGETPCTVTVSETQLLCEPPNLTGQHKVMVHVGGMVF B3DK42_DANRE B3DK42_DANRE ILKGRNFLPPTPGGNGKLNYTVLIGDKPCALTVSDTQLLCESPNLTGRHKVLARVGGIEF PLXA4_DANRE PLXA4_DANRE ILKGRNFLPPTPGGNGKLNYTVLIGDKPCALTVSDTQLLCESPNLTGRHKVLARVGGIEF B7WNM6_HUMAN B7WNM6_HUMAN ILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPNLIGRHKVMARVGGMEY PLXA4_HUMAN PLXA4_HUMAN ILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPNLIGRHKVMARVGGMEY B9EJ29_MOUSE B9EJ29_MOUSE ILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPNLIGRHKVMARVGGMEY PLXA4_MOUSE PLXA4_MOUSE ILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPNLIGRHKVMARVGGMEY MATCH *:*: * . : . ::.* * . * CONSENSUS ?LKG?NL?P????G???LNYTV?IG??PC??TVS??QLLC?SP??TG???V????GG?E?

A8IYK2_DANRE A8IYK2_DANRE SPGTLQIYSDSLLTLPAIIGIGGGGGLLLLVIIIILIAYKRKSRDADRTLKRLQMQMHNL Q5U5A2_XENLA Q5U5A2_XENLA SPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTLKRLQLQMDNL A2RUV3_XENTR A2RUV3_XENTR SPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTLKRLQLQMDNL Q91823_XENLA Q91823_XENLA SPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTLKRLQLQMDNL PLXA1_HUMAN PLXA1_HUMAN SPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNL PLXA1_MOUSE PLXA1_MOUSE SPGMLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNL A5D6Q5_MOUSE A5D6Q5_MOUSE WLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNL P70208_MOUSE P70208_MOUSE WLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNL B5FW97_OTOGA B5FW97_OTOGA WLGTLHITAEQALTLPAMVGLATGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNL B2KIK2_RHIFE B2KIK2_RHIFE WLGTLHITAERALTLPAMVGLAVGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNL B7NZQ8_RABIT B7NZQ8_RABIT WLGTLHITAERALTLPAMVGLAAGGGFLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNL B1MTV7_CALMO B1MTV7_CALMO WLGTLHISAERALTLPAMVGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNL A9CB66_PAPAN A9CB66_PAPAN WLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNL PLXA3_HUMAN PLXA3_HUMAN WLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNL Q4T5C4_TETNG Q4T5C4_TETNG SPGMLHIYSDSALTLPAIIGIGAGGGVLLIAIIAVLIAYKRKTRDADRTLKRLQLQMDNL A5JJU2_DANRE A5JJU2_DANRE SPGMLHIYSDSTLTLPAIIGIGAGGGVLLIAIIAVLIAYKRKTRDADRTLKRLQLQMDNL B0S5N4_DANRE B0S5N4_DANRE SPGMLHIYSDSTLTLPAIIGIGAGGGVLLIAIIAVLIAYKRKTRDADRTLKRLQLQMDNL B3DKK4_DANRE B3DKK4_DANRE SPGMLHIYSDSTLTLPAIIGIGAGGGVLLIAIIAVLIAYKRKTRDADRTLKRLQLQMDNL A8IYK6_DANRE A8IYK6_DANRE SPGMLHIYSDSTLTLPAIIGIGAGGGVLLIAIIAVLIAYKRKTRDADRTLKRLQLQMDNL Q4S650_TETNG Q4S650_TETNG ----------ALLTLPAIVSIAAGGGLLLIIVILVLIAYKRKSRENDLTLKRLQMQMDNL B1WB12_XENTR B1WB12_XENTR SPGSINVIPDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNL PLXA2_HUMAN PLXA2_HUMAN SPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNL PLXA2_MOUSE PLXA2_MOUSE SPGSVSVISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNL B3DK42_DANRE B3DK42_DANRE SPGVVHITSDSPLSSTAVISIAGAGGLLIFFIVIVLIAYKRKSRESDLTLKRLQMQMDNL PLXA4_DANRE PLXA4_DANRE SPGVVHITSDSPLSSTAVISIAGAGGLLIFFIVIVLIAYKRKSRESDLTLKRLQMQMDNL B7WNM6_HUMAN B7WNM6_HUMAN SPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRKSRESDLTLKRLQMQMDNL PLXA4_HUMAN PLXA4_HUMAN SPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRKSRESDLTLKRLQMQMDNL B9EJ29_MOUSE B9EJ29_MOUSE SPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRKSRESDLTLKRLQMQMDNL PLXA4_MOUSE PLXA4_MOUSE SPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRKSRESDLTLKRLQMQMDNL MATCH *: .*::.:. .*..*:: : :*:*****::: * ******:**.** CONSENSUS ??G?????????L?LPA???????GG?L???I??VL?AYKRK????D?TLKRLQ?QMDNL

A8IYK2_DANRE A8IYK2_DANRE ESRVALECKEAFAELQTDIHELTQDLDGSGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVP Q5U5A2_XENLA Q5U5A2_XENLA ESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRIYAMRVLFPGIEDHPVLKEMEVQ A2RUV3_XENTR A2RUV3_XENTR ESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVQ Q91823_XENLA Q91823_XENLA ESRVALECKEAFAELQTDIHELTNDLDGAGIPFLEYRTYAMRVLFPGIEDHPVLKEMEVQ PLXA1_HUMAN PLXA1_HUMAN ESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVQ PLXA1_MOUSE PLXA1_MOUSE ESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVQ A5D6Q5_MOUSE A5D6Q5_MOUSE ESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP P70208_MOUSE P70208_MOUSE ESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP B5FW97_OTOGA B5FW97_OTOGA ESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP B2KIK2_RHIFE B2KIK2_RHIFE ESRVALECKEAFAELQTDINELTNHMDVVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP B7NZQ8_RABIT B7NZQ8_RABIT ESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP B1MTV7_CALMO B1MTV7_CALMO ESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP A9CB66_PAPAN A9CB66_PAPAN ESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP PLXA3_HUMAN PLXA3_HUMAN ESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTP Q4T5C4_TETNG Q4T5C4_TETNG ESRVALECKEAFAELQTDIQELTNDMDGVKIPFLEYRTYTMRVMFPGIEEHPVLKELDSP A5JJU2_DANRE A5JJU2_DANRE ESRVALECKEAFAELQTDIQELTNDMDGVKIPFLEYRTYTMRVMFPGIEEHPVLKELDSP B0S5N4_DANRE B0S5N4_DANRE ESRVALECKEAFAELQTDIQELTNDMDGVKIPFLEYRTYTMRVMFPGIEEHPVLKELDSP B3DKK4_DANRE B3DKK4_DANRE ESRVALECKEAFAELQTDIQELTNDMDGVKIPFLEYRTYTMRVMFPGIEEHPVLKELDSP A8IYK6_DANRE A8IYK6_DANRE ESRVALECKEAFAELQTDIQELTNDMDGVKIPFLEYRTYTMRVMFPGIEEHPVLKELDSP Q4S650_TETNG Q4S650_TETNG ESRVALECKEAFAELQTDINELTSDLDRAGIPYLDYRTYAMRVLFPGIDDHPVLRELEVP B1WB12_XENTR B1WB12_XENTR ESRVALECKEAFAELQTDINELTSDLDRSGIPHLDYRTYAMRVLFPGIEDHPVLQELEVQ PLXA2_HUMAN PLXA2_HUMAN ESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQ PLXA2_MOUSE PLXA2_MOUSE ESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQ B3DK42_DANRE B3DK42_DANRE ESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEEHPVLRDLEVP PLXA4_DANRE PLXA4_DANRE ESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEEHPVLRDLEVP B7WNM6_HUMAN B7WNM6_HUMAN ESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVP PLXA4_HUMAN PLXA4_HUMAN ESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVP B9EJ29_MOUSE B9EJ29_MOUSE ESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVP PLXA4_MOUSE PLXA4_MOUSE ESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVP MATCH *******************:***..:* **.*:** *::**:****: ****:::: CONSENSUS ESRVALECKEAFAELQTDI?ELT???D???IPFL?YRTY??RVLFPGIE?HPVL??????

A8IYK2_DANRE A8IYK2_DANRE AN----VEKALTLFGQLLNKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMSGLQGEMEYA Q5U5A2_XENLA Q5U5A2_XENLA AN----VEQSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYA A2RUV3_XENTR A2RUV3_XENTR AN----VEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYA Q91823_XENLA Q91823_XENLA AN----VEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYA PLXA1_HUMAN PLXA1_HUMAN AN----VEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYA PLXA1_MOUSE PLXA1_MOUSE AN----VEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYA