Alignment of the gene Family HBG106657 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q7TN96_RAT Q7TN96_RAT RAARGLCFFLSLCALCSCATRKYYLGAVELPWDYVSGGASGAQRSDSRFPPGTPAP---S FA8_MOUSE FA8_MOUSE QIALFACFFLSLFNFCSSAIRRYYLGAVELSWNYIQSDLLSVLHTDSRFLPRMSTSFPFN B7ZNH8_MOUSE B7ZNH8_MOUSE QIALFACFFLSLFNFCSSAIRRYYLGAVELSWNYIQSDLLSVLHTDSRFLPRMSTSFPFN A2AN88_MOUSE A2AN88_MOUSE QIALFACFFLSLFNFCSSAIRRYYLGAVELSWNYIQSDLLSVLHTDSRFLPRMSTSFPFN B2RRC9_MOUSE B2RRC9_MOUSE QIALFACFFLSLFNFCSSAIRRYYLGAVELSWNYIQSDLLSVLHTDSRFLPRMSTSFPFN FA8_PIG FA8_PIG QLELSTCVFLCLLPLGFSAIRRYYLGAVELSWDYRQSELLRELHVDTRFPATAPGALPLG B1PL82_RABIT B1PL82_RABIT ------------------------------------------------------------ B7NZR5_RABIT B7NZR5_RABIT QIELSTCFFVCILQLSFSATRRYYLGAVELSWDYMHSDLLSELHVDTRSPPRMPRSFPFN B0KWU5_CALJA B0KWU5_CALJA QMELSTCFFLCLLPFCFSATRRYYLGAVELPWNYMQSDL-SELPVDTRFPPRVPRSFPFN A8KA37_HUMAN A8KA37_HUMAN QIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDL-GELPVDARFPPRVPKSFPFN FA8_HUMAN FA8_HUMAN QIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDL-GELPVDARFPPRVPKSFPFN Q5HY69_HUMAN Q5HY69_HUMAN QIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDL-GELPVDARFPPRVPKSFPFN FA8_CANFA FA8_CANFA QVELYTCCFLCLLPFSLSATRKYYLGAVELSWDYMQSDLLSALHADTSFSSRVPGSLPLT B2KIK9_RHIFE B2KIK9_RHIFE RIELSTCFFLCFLPFSFSATRRYYLGAVELSWDYTQSELLSELHMDTRFPPRVPRTFPFS MATCH CONSENSUS ???L??C?FL???????SA?R?YYLGAVEL?W?Y??S?L???L??D?RF????????P??

Q7TN96_RAT Q7TN96_RAT AHVVHTKTVFVEYMDRFFHTAKPRPLWMGLLGPTIWTEVHDTVVITLKNMASHPVSLHAV FA8_MOUSE FA8_MOUSE TSIMYKKTVFVEYKDQLFNIAKPRPPWMGLLGPTIWTEVHDTVVITLKNMASHPVSLHAV B7ZNH8_MOUSE B7ZNH8_MOUSE TSIMYKKTVFVEYKDQLFNIAKPRPPWMGLLGPTIWTEVHDTVVITLKNMASHPVSLHAV A2AN88_MOUSE A2AN88_MOUSE TSIMYKKTVFVEYKDQLFNIAKPRPPWMGLLGPTIWTEVHDTVVITLKNMASHPVSLHAV B2RRC9_MOUSE B2RRC9_MOUSE TSIMYKKTVFVEYKDQLFNIAKPRPPWMGLLGPTIWTEVHDTVVITLKNMASHPVSLHAV FA8_PIG FA8_PIG PSVLYKKTVFVEFTDQLFSVARPRPPWMGLLGPTIQAEVYDTVVVTLKNMASHPVSLHAV B1PL82_RABIT B1PL82_RABIT ---------------------------------TIWAEVHDTVVITLKNMASHPVSLHAV B7NZR5_RABIT B7NZR5_RABIT TSVIYKKTVFVEFTDQLFNIVKPRPPWMGLLGPTIWAEVHDTVVITLKNMASHPVSLHAV B0KWU5_CALJA B0KWU5_CALJA NSVMYKKTVFVEFTDHLFNIAKPKPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV A8KA37_HUMAN A8KA37_HUMAN TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV FA8_HUMAN FA8_HUMAN TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV Q5HY69_HUMAN Q5HY69_HUMAN TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV FA8_CANFA FA8_CANFA TSVTYRKTVFVEFTDDLFNIAKPRPPWMGLLGPTIQAEVYDTVVIVLKNMASHPVSLHAV B2KIK9_RHIFE B2KIK9_RHIFE TSVMYKKTVFVEFTDHLFNIAKPRPPWMGLLGPTIRAEVYDTVVVTLKNMASHAVSLHAV MATCH ** :**:****:.*******.****** CONSENSUS ?S??Y?KT?FVE??D?LF??AKPRPPWMGLLGPTI??EV?DTVVITLKNMASHPVSLHAV

Q7TN96_RAT Q7TN96_RAT GMSFWKASEGAAYDDHSSPAEKDDDKVLPGESHTYAWQVLGESGPMASDPPCLTYAYLSH FA8_MOUSE FA8_MOUSE GVSYWKASEGDEYEDQTSQMEKEDDKVFPGESHTYVWQVLKENGPMASDPPCLTYSYMSH B7ZNH8_MOUSE B7ZNH8_MOUSE GVSYWKASEGDEYEDQTSQMEKEDDKVFPGESHTYVWQVLKENGPMASDPPCLTYSYMSH A2AN88_MOUSE A2AN88_MOUSE GVSYWKASEGDEYEDQTSQMEKEDDKVFPGESHTYVWQVLKENGPMASDPPCLTYSYMSH B2RRC9_MOUSE B2RRC9_MOUSE GVSYWKASEGDEYEDQTSQMEKEDDKVFPGESHTYVWQVLKENGPMASDPPCLTYSYMSH FA8_PIG FA8_PIG GVSFWKSSEGAEYEDHTSQREKEDDKVLPGKSQTYVWQVLKENGPTASDPPCLTYSYLSH B1PL82_RABIT B1PL82_RABIT GVSYWKASEGAEYDDQTSQREKEDDKIFPGESHTYVWQVLKENGPMASDPPCLTYSYLSH B7NZR5_RABIT B7NZR5_RABIT GVSYWKASEGAEYDDQTSQREKEDDKIFPGESHTYVWQVLKENGPMASDPPCLTYSYLSH B0KWU5_CALJA B0KWU5_CALJA GVSYWKASEGAEYDDQTTQREKEDDKVFPGGSHTYVWHVLKENGPMASDPLCLTYSYLSH A8KA37_HUMAN A8KA37_HUMAN GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH FA8_HUMAN FA8_HUMAN GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH Q5HY69_HUMAN Q5HY69_HUMAN GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH FA8_CANFA FA8_CANFA GVSYWKASEGAEYEDQTSQKEKEDDNVIPGESHTYVWQVLKENGPMASDPPCLTYSYFSH B2KIK9_RHIFE B2KIK9_RHIFE GVSYWKASEGAEYEDETSKTEKEDDKVIPGESHTYVWHVLKENGPMASDPPCLTYSYLSH MATCH *:*:**:*** *:*.:: **:**:::** *:**.*:** *.** **** ****:*:** CONSENSUS GVSYWKASEG?EY?D?TSQ?EKEDDKV?PG?SHTYVWQVLKENGPMASDP?CLTYSY?SH

Q7TN96_RAT Q7TN96_RAT VDLVRDLNSGLVGALLVCKEGRLSAERTRMPPHFVLLFAVFDEGRSWHAAT-------RD FA8_MOUSE FA8_MOUSE VDLVKDLNSGLIGALLVCKEGSLSKERTQMLYQFVLLFAVFDEGKSWHSETNDSYTQSMD B7ZNH8_MOUSE B7ZNH8_MOUSE VDLVKDLNSGLIGALLVCKEGSLSKERTQMLYQFVLLFAVFDEGKSWHSETNDSYTQSMD A2AN88_MOUSE A2AN88_MOUSE VDLVKDLNSGLIGALLVCKEGSLSKERTQMLYQFVLLFAVFDEGKSWHSETNDSYTQSMD B2RRC9_MOUSE B2RRC9_MOUSE VDLVKDLNSGLIGALLVCKEGSLSKERTQMLYQFVLLFAVFDEGKSWHSETNDSYTQSMD FA8_PIG FA8_PIG VDLVKDLNSGLIGALLVCREGSLTRERTQNLHEFVLLFAVFDEGKSWHSARNDSWTRAMD B1PL82_RABIT B1PL82_RABIT VDLVNDLNSGLIGALLVCREGSLAKETTQILHEFVLLFAVFDEGKTWHSGT-----PAMD B7NZR5_RABIT B7NZR5_RABIT VDLVKDLNSGLIGALLVCREGSLAKETTQILHEFVLLFAVFDEGKTWHSGT-----PAMD B0KWU5_CALJA B0KWU5_CALJA VDLVKDLNSGLIGALLVCREGSLAKERTQTLHTFVLLFAVFDEGKSWHTETKNSLIQDRD A8KA37_HUMAN A8KA37_HUMAN VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD FA8_HUMAN FA8_HUMAN VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD Q5HY69_HUMAN Q5HY69_HUMAN VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD FA8_CANFA FA8_CANFA VDLVKDLNSGLIGALLVCKEGSLAKERTQTLQEFVLLFAVFDEGKSWHSETNASLTQ--- B2KIK9_RHIFE B2KIK9_RHIFE VDPVKDLNSGLIGALLVCREGSLAKERTQTLQEFVLLFAVFNEGKSWHSETNEPSIRAMD MATCH ** *.******:******:** *: * *: *:******:**::**: CONSENSUS VDLVKDLNSGLIGALLVC?EGSL?KE?TQ?L??F?LLFAVFDEGKSWHS?T????????D

Q7TN96_RAT Q7TN96_RAT PASTEAQPTVHTVNGYTNRTLPGLTGCRGTSVYWHVMAVGTTPDIHSILLEGHTFSVRSH FA8_MOUSE FA8_MOUSE SASARDWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEIHSIFLEGHTFFVRNH B7ZNH8_MOUSE B7ZNH8_MOUSE SASARDWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEIHSIFLEGHTFFVRNH A2AN88_MOUSE A2AN88_MOUSE SASARDWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEIHSIFLEGHTFFVRNH B2RRC9_MOUSE B2RRC9_MOUSE SASARDWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEIHSIFLEGHTFFVRNH FA8_PIG FA8_PIG PAPARAQPAMHTVNGYVNRSLPGLIGCHKKSVYWHVIGMGTSPEVHSIFLEGHTFLVRHH B1PL82_RABIT B1PL82_RABIT SASAQAWPKMHTVNGYVNRSLPGLIGCHRKQVYWHVIGMGTTPEVHSIFLEGHTFLVRNH B7NZR5_RABIT B7NZR5_RABIT SASAQAWPKMHTVNGYVNRSLPGLIGCHRKQVYWHVIGMGTTPEVHSIFLEGHTFLVRNH B0KWU5_CALJA B0KWU5_CALJA AAAARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH A8KA37_HUMAN A8KA37_HUMAN AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH FA8_HUMAN FA8_HUMAN AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH Q5HY69_HUMAN Q5HY69_HUMAN AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH FA8_CANFA FA8_CANFA ---AEAQHELHTINGYVNRSLPGLTVCHKRSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH B2KIK9_RHIFE B2KIK9_RHIFE TPSARARPEMHTINGYVNRSLPGLSGCHKKLVYWHVIGMGTTPEVHSIFLEGHTFLVRNH MATCH :. :**:***.**:**** *: *****:.:**:*::***:****** ** * CONSENSUS ?A?A???P?MHTVNGYVNRSLPGL?GCH?K?VYWHVIGMGTTPE?HSIFLEGHTF?VRNH

Q7TN96_RAT Q7TN96_RAT RQASLEISPMTLLTAQTWLMDLGRFLLFCHISSHRHGGMEAYVQVDNCPEAPQGQGK-RD FA8_MOUSE FA8_MOUSE RQASLEISPITFLTAQTLLIDLGQFLLFCHISSHKHDGMEAYVKVDSCPEESQWQKKNNN B7ZNH8_MOUSE B7ZNH8_MOUSE RQASLEISPITFLTAQTLLIDLGQFLLFCHISSHKHDGMEAYVKVDSCPEESQWQKKNNN A2AN88_MOUSE A2AN88_MOUSE RQASLEISPITFLTAQTLLIDLGQFLLFCHISSHKHDGMEAYVKVDSCPEESQWQKKNNN B2RRC9_MOUSE B2RRC9_MOUSE RQASLEISPITFLTAQTLLIDLGQFLLFCHISSHKHDGMEAYVKVDSCPEESQWQKKNNN FA8_PIG FA8_PIG RQASLEISPLTFLTAQTFLMDLGQFLLFCHISSHHHGGMEAHVRVESCAEEPQLRRK-AD B1PL82_RABIT B1PL82_RABIT RQASLEISPITFLTAETLLMDLGQFLLFCHISSHQHDGMEAYIKVDKCPEEPQLRMK-NH B7NZR5_RABIT B7NZR5_RABIT RQASLEISPITFLTAETLLMDLGQFLLFCHISSHQHDGMEAYIKVDKCPEEPQLRMK-NH B0KWU5_CALJA B0KWU5_CALJA RQASLEISPITFLTAQTVLMDLGQFLLFCHISSHQHDGMEAYVEVDSCPEEPQLRMK-NN A8KA37_HUMAN A8KA37_HUMAN RQASLEIPPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMK-NN FA8_HUMAN FA8_HUMAN RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMK-NN Q5HY69_HUMAN Q5HY69_HUMAN RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMK-NN FA8_CANFA FA8_CANFA RQASLEISPITFLTAQTFLMDLGQFLLFCHIPSHQHDGMEAYVKVDSCPEEPQLRMK-NN B2KIK9_RHIFE B2KIK9_RHIFE REASLEISPVTFLTAQTLLMDLGQFLLYCHISSHQHDGMEAYLKVDSCPEEPQLRMK-NI MATCH *:*****.*:*:***:* *:***:***:***.**:*.****::.*:.*.* .* : * CONSENSUS RQASLEISP?TFLTAQT?L?DLGQFLLFCHISSH?HDGMEAY??VD?CPEE?Q???K?N?

Q7TN96_RAT Q7TN96_RAT EDTEDYDD--LDSEMDVFTWDPDAAP-FVQVRSAAKRHPKTWVHYIAAEEGDWDYAPAAA FA8_MOUSE FA8_MOUSE EEMEDYDDDLY-SEMDMFTLDYDSSP-FIQIRSVAKKYPKTWIHYISAEEEDWDYAPSVP B7ZNH8_MOUSE B7ZNH8_MOUSE EEMEDYDDDLY-SEMDMFTLDYDSSP-FIQIRSVAKKYPKTWIHYISAEEEDWDYAPSVP A2AN88_MOUSE A2AN88_MOUSE EEMEDYDDDLY-SEMDMFTLDYDSSP-FIQIRSVAKKYPKTWIHYISAEEEDWDYAPSVP B2RRC9_MOUSE B2RRC9_MOUSE EEMEDYDDDLY-SEMDMFTLDYDSSP-FIQIRSVAKKYPKTWIHYISAEEEDWDYAPSVP FA8_PIG FA8_PIG EE-EDYDDNLYDSDMDVVRLDGDDVSPFIQIRSVAKKHPKTWVHYISAEEEDWDYAPAVP B1PL82_RABIT B1PL82_RABIT EEEEYYDDDVKDSEMDVFRFDDDNSASYIQIRSVAKKHPKTWIHYIAAEEEDWDYAPSVA B7NZR5_RABIT B7NZR5_RABIT EEEEYYDDDVKDSEMDVFRFDDDNSASYIQIRSVAKKHPKTWIHYIAAEEEDWDYAPSVA B0KWU5_CALJA B0KWU5_CALJA EEEEDYDNDFADSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPSVL A8KA37_HUMAN A8KA37_HUMAN EEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVL FA8_HUMAN FA8_HUMAN EEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVL Q5HY69_HUMAN Q5HY69_HUMAN EEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVL FA8_CANFA FA8_CANFA ED-KDYDDGLYDSDMDVVSFDDDSSSPFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPSGP B2KIK9_RHIFE B2KIK9_RHIFE EE-DDYYEDPYDSDMDIVRLDDNYSPPVLQIRSVAKKHPKTWVHYIAAEEDDWEYAPSGP MATCH *: . * : *:**:. * : . :*:**.**::****:***:*** **:*** CONSENSUS EE?EDYDD????S?MD????D?D?S???IQIRSVAKK?PKTW?HYI?AEEEDWDYAP???

Q7TN96_RAT Q7TN96_RAT TLEDGSLRNRYLGRGPGRIGSKYKKVRFVAYTDGTFHTREATPREAGLLGPLLYGEVGDS FA8_MOUSE FA8_MOUSE TSDNGSYKSQYLSNGPHRIGRKYKKVRFIAYTDETFKTRETIQHESGLLGPLLYGEVGDT B7ZNH8_MOUSE B7ZNH8_MOUSE TSDNGSYKSQYLSNGPHRIGRKYKKVRFIAYTDETFKTRETIQHESGLLGPLLYGEVGDT A2AN88_MOUSE A2AN88_MOUSE TSDNGSYKSQYLSNGPHRIGRKYKKVRFIAYTDETFKTRETIQHESGLLGPLLYGEVGDT B2RRC9_MOUSE B2RRC9_MOUSE TSDNGSYKSQYLSNGPHRIGRKYKKVRFIAYTDETFKTRETIQHESGLLGPLLYGEVGDT FA8_PIG FA8_PIG SPSDRSYKSLYLNSGPQRIGRKYKKARFVAYTDVTFKTRKAIPYESGILGPLLYGEVGDT B1PL82_RABIT B1PL82_RABIT TPDDRSYQSQYLNNGPQRIGRKYKKVRFMAYTDETFKTRETMQYESGILGPLLYGEVGDT B7NZR5_RABIT B7NZR5_RABIT TPDDRSYQSQYLNNGPQRIGRKYKKVRFMAYTDETFKTRETMQYESGILGPLLYGEVGDT B0KWU5_CALJA B0KWU5_CALJA APSDRSYKSQYLNNGPQRIGRRYKKVRFMAYTDETFKTREPIQYESGILGPLLYGEVGDT A8KA37_HUMAN A8KA37_HUMAN APDDRGYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDT FA8_HUMAN FA8_HUMAN APDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDT Q5HY69_HUMAN Q5HY69_HUMAN APDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDT FA8_CANFA FA8_CANFA TPNDRSHKNLYLNNGPQRIGKKYKKVRFVAYTDETFKTREAIQYESGILGPLLYGEVGDT B2KIK9_RHIFE B2KIK9_RHIFE TSSDTSYKSLYLKNGPQQIGRKYKKVRFMAYTDETFTTREAIQYESGILGPLLYGEVGDT MATCH : .: . :. ** ** :** :***.**:**** ** **:. *:*:***********: CONSENSUS ?????SY?S?YL?NGP?RIGRKYKKVRF?AYTDETFKTRE??Q?ESG?LGPLLYGEVGDT

Q7TN96_RAT Q7TN96_RAT LLIVFKNRASRAYNIHPHGIRDVGAVHAGRLPRGVKHVKDLPIRPGETFKYRWTLTAEDG FA8_MOUSE FA8_MOUSE LLIIFKNQASRPYNIYPHGITDVSPLHARRLPRGIKHVKDLPIHPGEIFKYKWTVTVEDG B7ZNH8_MOUSE B7ZNH8_MOUSE LLIIFKNQASRPYNIYPHGITDVSPLHARRLPRGIKHVKDLPIHPGEIFKYKWTVTVEDG A2AN88_MOUSE A2AN88_MOUSE LLIIFKNQASRPYNIYPHGITDVSPLHARRLPRGIKHVKDLPIHPGEIFKYKWTVTVEDG B2RRC9_MOUSE B2RRC9_MOUSE LLIIFKNQASRPYNIYPHGITDVSPLHARRLPRGIKHVKDLPIHPGEIFKYKWTVTVEDG FA8_PIG FA8_PIG LLIIFKNKASRPYNIYPHGITDVSALHPGRLLKGWKHLKDMPILPGETFKYKWTVTVEDG B1PL82_RABIT B1PL82_RABIT LLIIFKNQASRPYNIYPHGITDVSPLHSGRLSKGMKHLKDLPILPGEIFKYKWKVTVEDG B7NZR5_RABIT B7NZR5_RABIT LLIIFKNQASRPYNIYPHGITDVSPLHSGRLSKGMKHLKDLPILPGEIFKYKWKVTVEDG B0KWU5_CALJA B0KWU5_CALJA LLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDG A8KA37_HUMAN A8KA37_HUMAN LLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDG FA8_HUMAN FA8_HUMAN LLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDG Q5HY69_HUMAN Q5HY69_HUMAN LLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDG FA8_CANFA FA8_CANFA LLIIFKNQASRPYNIYPHGINYVTPLHTGRLPKGVKHLKDMPILPGEIFKYKWTVTVEDG B2KIK9_RHIFE B2KIK9_RHIFE LLIIFKNQASRPYNIFPHGITDVTPLHSGRLPKGVKHLKDMPILPGETFKYKWTVTVEDG MATCH ***:***:***.***.**** * .::. ** :* **:**:** *** ***:*.:*.*** CONSENSUS LLIIFKNQASRPYNIYPHGITDV?PL???RL??G?KH?KD?PI?PGE?FKYKWTVTVEDG

Q7TN96_RAT Q7TN96_RAT PARSDARCVTRYYASAVDPERDLASGLIGPLLICCKESVDQRGNQMMSDERNVILFSVFD FA8_MOUSE FA8_MOUSE PTKSDPRCLTRYYSSFINPERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSIFD B7ZNH8_MOUSE B7ZNH8_MOUSE PTKSDPRCLTRYYSSFINPERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSIFD A2AN88_MOUSE A2AN88_MOUSE PTKSDPRCLTRYYSSFINPERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSIFD B2RRC9_MOUSE B2RRC9_MOUSE PTKSDPRCLTRYYSSFINPERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSIFD FA8_PIG FA8_PIG PTKSDPRCLTRYYSSSINLEKDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFD B1PL82_RABIT B1PL82_RABIT PTKSDPRCLTRYYSSFINLDRDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFD B7NZR5_RABIT B7NZR5_RABIT PTKSDPRCLTRYYSSFINLDRDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFD B0KWU5_CALJA B0KWU5_CALJA PTKSDPRCLTRYYSSFINMERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFD A8KA37_HUMAN A8KA37_HUMAN PTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFD FA8_HUMAN FA8_HUMAN PTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFD Q5HY69_HUMAN Q5HY69_HUMAN PTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFD FA8_CANFA FA8_CANFA PTKSDPRCLTRYYSSFINLERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFD B2KIK9_RHIFE B2KIK9_RHIFE PTKSDPRCLTRYYSSFVNLERDLASGLIGPLLICYKESVDQRGNQMMSDKRNVILFSVFD MATCH *::**.**:****:* :: ::************* **********:***:*******:** CONSENSUS PTKSDPRCLTRYYSSF?N?ERDLASGLIGPLLICYKESVDQRGNQ?MSDKRNVILFS?FD

Q7TN96_RAT Q7TN96_RAT ENRSWYISENMRRFLPDEAHVQLQDPEFEASNLMHSINGYVFDGLELRVCLHEVAAWHVL FA8_MOUSE FA8_MOUSE ENQSWYITENMQRFLPNAAKTQPQDPGFQASNIMHSINGYVFDSLELTVCLHEVAYWHIL B7ZNH8_MOUSE B7ZNH8_MOUSE ENQSWYITENMQRFLPNAAKTQPQDPGFQASNIMHS------------------------ A2AN88_MOUSE A2AN88_MOUSE ENQSWYITENMQRFLPNAAKTQPQDPGFQASNIMHSINGYVFDSLELTVCLHEVAYWHIL B2RRC9_MOUSE B2RRC9_MOUSE ENQSWYITENMQRFLPNAAKTQPQDPGFQASNIMHS------------------------ FA8_PIG FA8_PIG ENQSWYLAENIQRFLPNPDGLQPQDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYIL B1PL82_RABIT B1PL82_RABIT ENQSWYLTENMQRFLPEAAGVQPQDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYIL B7NZR5_RABIT B7NZR5_RABIT ENQSWYLTENMQRFLPEAAGVQPQDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYIL B0KWU5_CALJA B0KWU5_CALJA ENQSWYLTENMQRFLPSATGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYIL A8KA37_HUMAN A8KA37_HUMAN ENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYIL FA8_HUMAN FA8_HUMAN ENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYIL Q5HY69_HUMAN Q5HY69_HUMAN ENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYIL FA8_CANFA FA8_CANFA ENRSWYLTENMQRFLPNADVVQPHDPEFQLSNIMHSINGYVFDNLQLSVCLHEVAYWYIL B2KIK9_RHIFE B2KIK9_RHIFE ENQSWYLTENMQRFLPNADGVQPQDPEFQLSNIMYSINGYVFDSLQLSVCLHEVAYWYIL MATCH **:***::**::****. * .** *: **:*:* CONSENSUS EN?SWY?TEN?QRFLP?????Q??DP?FQASNIMHSINGYVFD?L?L?VCLHEVA?W??L

Q7TN96_RAT Q7TN96_RAT SVGAQTDFLSVFFSGHTFRHRAVYADTLTVFPHSGVTVFMSMDNPGVWVLGCHNPDFRES FA8_MOUSE FA8_MOUSE SVGAQTDFLSIFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVLGCHNSDFRKR B7ZNH8_MOUSE B7ZNH8_MOUSE ----------------------------------------------LWVLGCHNSDFRKR A2AN88_MOUSE A2AN88_MOUSE SVGAQTDFLSIFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVLGCHNSDFRKR B2RRC9_MOUSE B2RRC9_MOUSE ----------------------------------------------LWVLGCHNSDFRKR FA8_PIG FA8_PIG SVGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVLGCHNSDLRNR B1PL82_RABIT B1PL82_RABIT SVGAQTDFLSIFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVIGCHNSDFRNR B7NZR5_RABIT B7NZR5_RABIT SVGAQTDFLSIFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVIGCHNSDFRNR B0KWU5_CALJA B0KWU5_CALJA SIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNR A8KA37_HUMAN A8KA37_HUMAN SIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNR FA8_HUMAN FA8_HUMAN SIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNR Q5HY69_HUMAN Q5HY69_HUMAN SIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNR FA8_CANFA FA8_CANFA SVGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWVLGCHNSDFRNR B2KIK9_RHIFE B2KIK9_RHIFE SVGAQTDFLSVFFSGYTFEHKLVYEDTLTLFPFSGETVFMSMENPGVWALGCHNSDFRNR MATCH :* :****.*:*: CONSENSUS S?GAQTDFLS?FFSG?TF?H??VY?DTLT?FP?SG?TVFMSM?NPGLW?LGCHNSDFR?R

Q7TN96_RAT Q7TN96_RAT GMTALLKVSSCDEGVSDYYGETYEGVLAPLAN-DNAVDPRSFSQNSNHLHSRKKK----- FA8_MOUSE FA8_MOUSE GMTALLKVSSCDKSTSDYYEEIYEDIPTQLVNENNVIDPRSFFQNTNHPNTRKKKFKDST B7ZNH8_MOUSE B7ZNH8_MOUSE GMTALLKVSSCDKSTSDYYEEIYEDIPTQLVNENNVIDPRSFFQNTNHPNTRKKKFKDST A2AN88_MOUSE A2AN88_MOUSE GMTALLKVSSCDKSTSDYYEEIYEDIPTQLVNENNVIDPRSFFQNTNHPNTRKKKFKDST B2RRC9_MOUSE B2RRC9_MOUSE GMTALLKVSSCDKSTSDYYEEIYEDIPTQLVNENNVIDPRSFFQNTNHPNTRKKKFKDST FA8_PIG FA8_PIG GMTALLKVYSCDRDIGDYYDNTYEDIPGFLLSGKNVIEPRSFAQNSRPPSASQKQFQTIT B1PL82_RABIT B1PL82_RABIT GMTALLKVSTCDRNIGDYYEDIYEDMPIHLLNENNGIEPRSFSQNSRHARTRQKQFTATT B7NZR5_RABIT B7NZR5_RABIT GMTALLKVSTCDRNIGDYYEDIYEDMPIHLLNENNGIEPRSFSQNSRHARTRQKQFTATT B0KWU5_CALJA B0KWU5_CALJA GMTALLKVSSCDKNTGDYYEDTYEDISTYLLSENNGIEPRSFSQNSRHPSTRQNQFNATT A8KA37_HUMAN A8KA37_HUMAN GMTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATT FA8_HUMAN FA8_HUMAN GMTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATT Q5HY69_HUMAN Q5HY69_HUMAN GMTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATT FA8_CANFA FA8_CANFA GMTALLKVSSCNRNIDDYYEDTYEDIPTPLLNENNVIKPRSFSQNSRHPSTKEKQLKATT B2KIK9_RHIFE B2KIK9_RHIFE GMSALLKVSSCDRNTGDYYDDIYEDIPTSLLNENHVIEPRSFSQNTRHPSTRQKQSKATM MATCH **:***** :*:.. .*** : **.: * . .: :.**** **:. : ::: CONSENSUS GMTALLKVSSCD????DYY???YED????L???NN?I?PRSF?QN??H??TR?K?????T

Q7TN96_RAT Q7TN96_RAT ---------------------------SNTPMRFPLSHPTQHGSFWSDSQGDVHDAVHRA FA8_MOUSE FA8_MOUSE IPKNDMEKIEPQFEEIAEMLKVQSVSVSDMLMLLGQSHPTPHGLFLSDGQEAIYEAIHDD B7ZNH8_MOUSE B7ZNH8_MOUSE IPKNDMEKIEPQFEEIAEMLKVQSVSVSDMLMLLGQSHPTPHGLFLSDGQEAIYEAIHDD A2AN88_MOUSE A2AN88_MOUSE IPKNDMEKIEPQFEEIAEMLKVQSVSVSDMLMLLGQSHPTPHGLFLSDGQEAIYEAIHDD B2RRC9_MOUSE B2RRC9_MOUSE IPKNDMEKIEPQFEEIAEMLKVQSVSVSDMLMLLGQSHPTPHGLFLSDGQEAIYEAIHDD FA8_PIG FA8_PIG SPEDDVE-LDPQSGERTQALEELSVPSGDGSMLLGQN-PAPHGSSSSDLQEARNEA--DD B1PL82_RABIT B1PL82_RABIT IPENDMENIDSPLGERMQMAKVQSVSSSDLLMLLGQS-PTPHGLALSDPQESTYEAVSDD B7NZR5_RABIT B7NZR5_RABIT IPENDMENIDSPLGERMQMAKVQSVSSSDLLMLLGQS-PTPHGLALSDLQESTYEAVSDD B0KWU5_CALJA B0KWU5_CALJA ITENDIEKTDPWFGHRTHMPKVQNVSSSDLLMLLQQS-PTPHGLSLPDLQEAKYETFSDD A8KA37_HUMAN A8KA37_HUMAN IPENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLSRQS-PTPHGLSLSDLQEAKYETFSDD FA8_HUMAN FA8_HUMAN IPENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQS-PTPHGLSLSDLQEAKYETFSDD Q5HY69_HUMAN Q5HY69_HUMAN IPENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQS-PTPHGLSLSDLQEAKYETFSDD FA8_CANFA FA8_CANFA TPENDIEKIDLQSGERTQLIKAQSVSSSDLLMLLGQN-PTPRGLFLSDLREATDRA--DD B2KIK9_RHIFE B2KIK9_RHIFE TPENDVEKTGPWSGERAQLLQVQSISSSDLLMLSGQN-PTPHGLSLSDLQEATYKA--DY MATCH .: * . *: :* .* : : CONSENSUS ?P?ND?E???????????????Q?VS?SD?LML??Q??PTPHGL?LSD?QE???????DD

Q7TN96_RAT Q7TN96_RAT HSPAAAHSNEGPAEAAQLEPKPHPGEKMALPPSW---LRAKRSLVTTMEAKRKKLDLQVQ FA8_MOUSE FA8_MOUSE HSPNAIDSNEGPSKVTQLRPESHHSEKIVFTPQPGLQLRSNKSLETTIEVKWKKLGL--Q B7ZNH8_MOUSE B7ZNH8_MOUSE HSPNAIDSNEGPSKVTQLRPESHHSEKIVFTPQPGLQLRSNKSLETTIEVKWKKLGL--Q A2AN88_MOUSE A2AN88_MOUSE HSPNAIDSNEGPSKVTQLRPESHHSEKIVFTPQPGLQLRSNKSLETTIEVKWKKLGL--Q B2RRC9_MOUSE B2RRC9_MOUSE HSPNAIDSNEGPSKVTQLRPESHHSEKIVFTPQPGLQLRSNKSLETTIEVKWKKLGL--Q FA8_PIG FA8_PIG YLPGARERNTAPSAAARLRPELHHSAERVLTPEP--------------EKELKKLDS--K B1PL82_RABIT B1PL82_RABIT NSPGATDHNEDLYKVAHLTPELHYSGGIIFTPEPGLKLRLNENLEVTTPVEFNELDL--K B7NZR5_RABIT B7NZR5_RABIT NSPGATDNNEDLYKVAHLTPELHYSGGIIFTPEPGLKLRLNENLEITTPVEFNELDL--K B0KWU5_CALJA B0KWU5_CALJA PSPGAIDSNDSPSEMTHLRPQLHHSGDMVFTPEPGLQLRLNEKLGTTMATELKKLNF--K A8KA37_HUMAN A8KA37_HUMAN PSPGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDF--K FA8_HUMAN FA8_HUMAN PSPGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDF--K Q5HY69_HUMAN Q5HY69_HUMAN PSPGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDF--K FA8_CANFA FA8_CANFA HSRGAIERNKGPPEVASLRPELRHSEDREFTPEPELQLRLNENLGTNTTVELKKLDL--K B2KIK9_RHIFE B2KIK9_RHIFE HLPGATERNKRPSEGAHLRPELRKSGDRGFTPEPELQLRVNENVGSTLTVELKKDDF--K MATCH * . * : : *: : . :.*. : :: . : CONSENSUS ?SP?A???N??????????P??H?S????FTP???L?LR?N??L??T?????KKL?????

Q7TN96_RAT Q7TN96_RAT VSGLPDDRTTA-VVAPDDPMAACKKAGSSGFPD-------ESSPAALGKKMYPRIRPHGP FA8_MOUSE FA8_MOUSE VSSLPSNLMTT-TILSDNLKATFEKTDSSGFPDMPVHSSSKLSTTAFGKKAYSLVGSHVP B7ZNH8_MOUSE B7ZNH8_MOUSE VSSLPSNLMTT-TILSDNLKATFEKTDSSGFPDMPVHSSSKLSTTAFGKKAYSLVGSHVP A2AN88_MOUSE A2AN88_MOUSE VSSLPSNLMTT-TILSDNLKATFEKTDSSGFPDMPVHSSSKLSTTAFGKKAYSLVGSHVP B2RRC9_MOUSE B2RRC9_MOUSE VSSLPSNLMTT-TILSDNLKATFEKTDSSGFPDMPVHSSSKLSTTAFGKKAYSLVGSHVP FA8_PIG FA8_PIG MSSSSDLLKTSPTIPSDTLSAETERTHSLGPPHPQVNFRSQLGAIVLGKNSSHFIGAGVP B1PL82_RABIT B1PL82_RABIT DSSSSHNLMTPPTIPSDNL-AGTEKSGSLGSPNMPVHVDSQLGTAILDKKLSIVIDSGIP B7NZR5_RABIT B7NZR5_RABIT DSSSSHNLMTPPTIPSDNL-AGTEKSGSLGSPNMPVHVDSQLGTAILDKKLSIVIDSGIP B0KWU5_CALJA B0KWU5_CALJA ISNSSNNLTS--TIPSDNVAVGTGNTSSLGSQNMPAHSHSQLDTTLFGKKSSPIIESGVP A8KA37_HUMAN A8KA37_HUMAN VSSTSNNLIS--TIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGP FA8_HUMAN FA8_HUMAN VSSTSNNLIS--TIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGP Q5HY69_HUMAN Q5HY69_HUMAN VSSTSNNLIS--TIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGP FA8_CANFA FA8_CANFA ISSSSDSLMTSPTIPSDKLAAATEKTGSLGPPNMSVHFNSHLGTIVFGNNSSHLIQSGVP B2KIK9_RHIFE B2KIK9_RHIFE ISRLSNYLMTSPTIPSEKLAAGTEKTGSLRPSNMPTHFSSQLGTTVFGKNSSHLIESGVP MATCH * . : .: .: . .: * . .. :.:: . * CONSENSUS ?S?????L????TI?SD?L?A??????S?G?P?M??H??S?L?T???GK???????S??P

Q7TN96_RAT Q7TN96_RAT LSIIEGNRDSNSSDSTLMYRLGSPPGDATSWTENRRGLGEKRSHRVAFLARGNTLLSD-- FA8_MOUSE FA8_MOUSE LNASEENSDSNILDSTLMYSQESLPRDNILSIENDRLLREKRFHGIALLTKDNTLFKDNV B7ZNH8_MOUSE B7ZNH8_MOUSE LNVSEENSDSNILDSTLMYSQESLPRDNILSMENDRLLREKRFHGIALLTKDNTLFKDNV A2AN88_MOUSE A2AN88_MOUSE LNVSEENSDSNILDSTLMYSQESLPRDNILSMENDRLLREKRFHGIALLTKDNTLFKDNV B2RRC9_MOUSE B2RRC9_MOUSE LNVSEENSDSNILDSTLMYSQESLPRDNILSMENDRLLREKRFHGIALLTKDNTLFKDNV FA8_PIG FA8_PIG LGSTEED-------------HESSLGENVSPVESDGIFEKERAHGPASLTKDDVLFKVNI B1PL82_RABIT B1PL82_RABIT LNLNERNNNPMLLEVDLMNNQESSLGKNI-SMDSDKLFKEKRVHESASLTKDNAPFKVPI B7NZR5_RABIT B7NZR5_RABIT LNLNERNNNPMLLEVDLMNNQESSLGKNI-SMDSDKLFKEKRVHESASLTKDNAPFKVPI B0KWU5_CALJA B0KWU5_CALJA LSLSEENNDSKLLESGLMDSQESSFGKNVSSTETGRLLKEKTAQ------------QVSI A8KA37_HUMAN A8KA37_HUMAN LSLSEENNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSI FA8_HUMAN FA8_HUMAN LSLSEENNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSI Q5HY69_HUMAN Q5HY69_HUMAN LSLSEENNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSI FA8_CANFA FA8_CANFA LELSEEDNDSKLLEAPLMNIQESSLRENVLSMESNRLFKEERIRGPASLIKDNALFKVNI B2KIK9_RHIFE B2KIK9_RHIFE LGLRKGDDESKLLEVALMNSQESSPGENILSMKSDRLFKEERAHGSASLTKGNSLFKVNT MATCH * : : * . .. : : : . CONSENSUS L???E???????L???LM??QES????N??S?????L????R?H??A?L?K?N??FK???

Q7TN96_RAT Q7TN96_RAT -------------VDEKSHAPGPT-SVGNSTAAVQDTILEICSEILEVTPPIHDRILSDK FA8_MOUSE FA8_MOUSE SLMKTNKTYNHSTTNEKLHTESPT-SIENSTTDLQDAILKVNSEIQEVTALIHDGTLLGK B7ZNH8_MOUSE B7ZNH8_MOUSE SLMKTNKTYNHSTTNEKLHTESPT-SIENSTTDLQDAILKVNSEIQEVTALIHDGTLLGK A2AN88_MOUSE A2AN88_MOUSE SLMKTNKTYNHSTTNEKLHTESPT-SIENSTTDLQDAILKVNSEIQEVTALIHDGTLLGK B2RRC9_MOUSE B2RRC9_MOUSE SLMKTNKTYNHSTTNEKLHTESPT-SIENSTTDLQDAILKVNSEIQEVTALIHDGTLLGK FA8_PIG FA8_PIG SLVKTNKARVYLKTNRKIHIDDAALLTENRASA----------------------TFMDK B1PL82_RABIT B1PL82_RABIT SLLKTNKLSHNSTTTKETHTDGPTLFIENSTSVWQNIILENDTEFQEVTSLIYDEMLMSK B7NZR5_RABIT B7NZR5_RABIT SLLKTNKLSHNSTTTKETHTDGPTLFIENSTSVWQNIILENDTEFQEVTSLIYDEMLMSK B0KWU5_CALJA B0KWU5_CALJA SLLKKKESSNNLATNRKTHTDGPTLLIENSTLVWQN-ILESDTEFQKVTPLIHDRMLTDK A8KA37_HUMAN A8KA37_HUMAN SLLKTNKTSNNSATNRKTHIDGPSLLIENSPSVWQN-ILESDTEFKKVTPLIHDRMLMDK FA8_HUMAN FA8_HUMAN SLLKTNKTSNNSATNRKTHIDGPSLLIENSPSVWQN-ILESDTEFKKVTPLIHDRMLMDK Q5HY69_HUMAN Q5HY69_HUMAN SLLKTNKTSNNSATNRKTHIDGPSLLIENSPSVWQN-ILESDTEFKKVTPLIHDRMLMDK FA8_CANFA FA8_CANFA SSVKTNRAPVNLTTNRKTRVAIPTLLIENSTSVWQDIMLERNTEFKEVTSLIHNETFMDR B2KIK9_RHIFE B2KIK9_RHIFE SLVKTNKSPVNSTTNRKTHTDGPTLLIENNTSVWQDSVLKSNAEFQEVTPLIHDEMFMDK MATCH . .: : .: * . : .: CONSENSUS SL?KTN???????T??K?H???P???IENS????Q???L????E???VT?LI?D?????K

Q7TN96_RAT Q7TN96_RAT SATYLRPHRTPDRITSTERKDIRHEKDGDLVPQDADDTSAPFSEAPFLSESTDWLKEANG FA8_MOUSE FA8_MOUSE NSTYLRLNHMLNRTTSTKNKDIFHRKDEDPIPQDEENTIMPFSKMLFLSESSNWFKKTNG B7ZNH8_MOUSE B7ZNH8_MOUSE NSTYLRLNHMLNRTTSTKNKDIFHRKDEDPIPQDEENTIMPFSKMLFLSESSNWFKKTNG A2AN88_MOUSE A2AN88_MOUSE NSTYLRLNHMLNRTTSTKNKDIFHRKDEDPIPQDEENTIMPFSKMLFLSESSNWFKKTNG B2RRC9_MOUSE B2RRC9_MOUSE NSTYLRLNHMLNRTTSTKNKDIFHRKDEDPIPQDEENTIMPFSKMLFLSESSNWFKKTNG FA8_PIG FA8_PIG NTTASGLNHVSN-----------------------------------------WIKGPLG B1PL82_RABIT B1PL82_RABIT NTTALRLNHELNKNTSSEDVKMVHQKKEGLVTPDAENPDMSFFKILLLPDSPNWFKRTYG B7NZR5_RABIT B7NZR5_RABIT NTTALRLNHELNKNTSSEDVKMVHQKKEGLVTPDAENPDMSFFKILLLPDSPNWFKRTYG B0KWU5_CALJA B0KWU5_CALJA NTTALRVNHMSNKTTSSKNMEIVHQKKEGPMPPDAENPNMSFFKMLFLSESANWIQRSHG A8KA37_HUMAN A8KA37_HUMAN NATALRLNHMSNKTTSS------------------------------------------- FA8_HUMAN FA8_HUMAN NATALRLNHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHG Q5HY69_HUMAN Q5HY69_HUMAN NATALRLNHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHG FA8_CANFA FA8_CANFA NTTALGLNHVSNKTTLSKNVEMAHQKKEDPVPLRAENPDLSSSKIPFLPD---WIK-THG B2KIK9_RHIFE B2KIK9_RHIFE NTTALGLNHVSNKTMSSKNMEMVHQEKEGPVPVGAEKPDRSLFKMLFLPDSANWIKRTQG MATCH .:* :: : CONSENSUS N?T?L?LNH??N??TS???????????????????????????????L?????W?????G

Q7TN96_RAT Q7TN96_RAT DNSAKPEQEPSPEQLVYLMYIKCMENQSFSSEKNKMIAGQGGFTKNTGLEDTVFPRKTSV FA8_MOUSE FA8_MOUSE NNSLNSEQEHSPKQLVYLMFKKYVKNQSFLSEKNKVTVEQDGFTKNIGLKDMAFPHNMSI B7ZNH8_MOUSE B7ZNH8_MOUSE NNSLNSEQEHSPKQLVYLMFKKYVKNQSFLSEKNKVTVEQDGFTKNIGLKDMAFPHNMSI A2AN88_MOUSE A2AN88_MOUSE NNSLNSEQEHSPKQLVYLMFKKYVKNQSFLSEKNKVTVEQDGFTKNIGLKDMAFPHNMSI B2RRC9_MOUSE B2RRC9_MOUSE NNSLNSEQEHSPKQLVYLMFKKYVKNQSFLSEKNKVTVEQDGFTKNIGLKDMAFPHNMSI FA8_PIG FA8_PIG KNPLSSERGPSPELLTSSGSGKSVKGQSSGQGRIRVAVEEEELSKG---KEMMLPNSELT B1PL82_RABIT B1PL82_RABIT KNSLNSAQGPGPKKLISLGSGKSVKDENFLSEKNKVAVGEDAFTKDTGLKEMILPSNGSM B7NZR5_RABIT B7NZR5_RABIT KNSLNSAQGPGPKKLISLGSGKSVKDENFLSEKNKVAVGEDAFTKDTGLKEMILPSNGSM B0KWU5_CALJA B0KWU5_CALJA NNSLNSGQGPSAKQLVSLGPEKSVEGQNFLSEENQVVVGKDEFTKDSGLKEMIFPSSRNL A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN KNSLNSGQGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNL Q5HY69_HUMAN Q5HY69_HUMAN KNSLNSGQGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNL FA8_CANFA FA8_CANFA KNSLSSEQRPSPKQLTSLGSEKSVKDQNFLSEE-KVVVGEDEFTKDTELQEI-FPNNKSI B2KIK9_RHIFE B2KIK9_RHIFE KNSLSSEQRPGPKQSTSLESEKSVKDQNSLSENNTVFVEEDEFTRDTGLKEVISPKSKSI MATCH CONSENSUS ?NSL?S?Q???P??L??L???K?V??????SE???V?V????FTK???L?????P?????

Q7TN96_RAT Q7TN96_RAT FLTTVAKRQESGRHNQE-NIPQAVTEKEAPIEEKGALPQVHIATGSKNFPRDMFVLGTGQ FA8_MOUSE FA8_MOUSE FLTTLSNVHENGRHNQEKNIQEEIE-KEALIEEKVVLPQVHEATGSKNFLKDILILGTRQ B7ZNH8_MOUSE B7ZNH8_MOUSE FLTTLSNVHENGRHNQEKNIQEEIE-KEALIEEKVVLPQVHEATGSKNFLKDILILGTRQ A2AN88_MOUSE A2AN88_MOUSE FLTTLSNVHENGRHNQEKNIQEEIE-KEALIEEKVVLPQVHEATGSKNFLKDILILGTRQ B2RRC9_MOUSE B2RRC9_MOUSE FLTTLSNVHENGRHNQEKNIQEEIE-KEALIEEKVVLPQVHEATGSKNFLKDILILGTRQ FA8_PIG FA8_PIG FLTNSADVQGNDTHSQGKKSREEMERREKLVQEKVDLPQVYTATGTKNFLRNIFHQSTEP B1PL82_RABIT B1PL82_RABIT FVTNLTNVWENDTHNQEKNFQEEVEKKEELVQENVVMPQVYTMNGTKNFLKKLFLVSTSQ B7NZR5_RABIT B7NZR5_RABIT FVTNLTNVWENDTHNQEKNFQEEVEKKEELVQENVVMPQVYTMNGTKNFLKKLFLVSTSQ B0KWU5_CALJA B0KWU5_CALJA FLTNLDNLHENSTHNQEKNIQEEIERKETLIQEDVVLPQIHTVTGTKNFMKNLFLLSTRQ A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN FLTNLDNLHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQ Q5HY69_HUMAN Q5HY69_HUMAN FLTNLDNLHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQ FA8_CANFA FA8_CANFA FFANLANVQENDTYNQEKKSPEEIERKEKLTQENVALPQAHTMIGTKNFLKNLFLLSTKQ B2KIK9_RHIFE B2KIK9_RHIFE FLTNLTNVQENDTYNQEKKSQEEIQRKEKVIQENVVLPTVY--TGTKNFLKNLFLLSSKQ MATCH CONSENSUS F?T??????EN???NQEK???EE???KE????E?V??PQ?????G?KNF????????T?Q

Q7TN96_RAT Q7TN96_RAT NIN-LHEETYVPVHKNVPWTRNPTDTRQIPMVHFFKKRKEEETNSGGLVNKTRETVRNYP FA8_MOUSE FA8_MOUSE NIS-LYE-VHVPVLQNITSINNSTNTVQIHMEHFFKRRKDKETNSEGLVNKTREMVKNYP B7ZNH8_MOUSE B7ZNH8_MOUSE NIS-LYE-VHVPVLQNITSINNSTNTVQIHMEHFFKRRKDKETNSEGLVNKTREMVKNYP A2AN88_MOUSE A2AN88_MOUSE NIS-LYE-VHVPVLQNITSINNSTNTVQIHMEHFFKRRKDKETNSEGLVNKTREMVKNYP B2RRC9_MOUSE B2RRC9_MOUSE NIS-LYE-VHVPVLQNITSINNSTNTVQIHMEHFFKRRKDKETNSEGLVNKTREMVKNYP FA8_PIG FA8_PIG SVEGFDGGSHAPVPQDSRSLNDSAERAETHIAHFSAIREEA--PLEAPGNRTGP------ B1PL82_RABIT B1PL82_RABIT NIG----------LDDTRPLNDSVNRADIQITHFSKRKEEEEDNLKGLGNQTKQMVDKYS B7NZR5_RABIT B7NZR5_RABIT NIG----------LDDTRPLNDSVNRADIQITHFSKRKEEEEDNLKGLGNQTKQMVDKYS B0KWU5_CALJA B0KWU5_CALJA HVESAYE----------GALNDSTHRT--------KKGEEE--NLEGLGNQTKQMVEKSP A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN NVEGSYDGAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEE--NLEGLGNQTKQIVEKYA Q5HY69_HUMAN Q5HY69_HUMAN NVEGSYDGAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEE--NLEGLGNQTKQIVEKYA FA8_CANFA FA8_CANFA NVAGLEEQPYTPILQDTRSLNDSPHSEGIHMANFSKIREEA--NLEGLGNQTNQMVERFP B2KIK9_RHIFE B2KIK9_RHIFE NVVGVDEETYTPIFQDTRSLNDSANRAGNHMAHFSKIRVET--NVEGLGNQTRQMVEKYQ MATCH CONSENSUS ????????????????????N?S??????????F?K???????N??GL?N?T???V????

Q7TN96_RAT Q7TN96_RAT ---------SQKNSVARRREQASGRIKA----------------SARWLPDVNRSIQSLL FA8_MOUSE FA8_MOUSE ---------SQKNITTQRSKRALGQFRL----------------STQWLKTINCSTQCII B7ZNH8_MOUSE B7ZNH8_MOUSE ---------SQKNITTQRSKRALGQFRL----------------STQWLKTINCSTQCII A2AN88_MOUSE A2AN88_MOUSE ---------SQKNITTQRSKRALGQFRL----------------STQWLKTINCSTQCII B2RRC9_MOUSE B2RRC9_MOUSE ---------SQKNITTQRSKRALGQFRL----------------STQWLKTINCSTQCII FA8_PIG FA8_PIG ---------GPRSAVPRRVKQSLKQIRLPLEEIKPERGVVLNATSTRWS----------- B1PL82_RABIT B1PL82_RABIT STTRMSPNLSQHNAINERGKQALKQFTHSLEEIEIERGISVDDTSTQQSKNTKYLTQSAL B7NZR5_RABIT B7NZR5_RABIT STTRMSPNLSQHNAINERGKQALKQFTHSLEEIEIERGISVDDTSTQQSKNTKYLTQSAL B0KWU5_CALJA B0KWU5_CALJA HTTKLSSNPSQQNVVTQRSKRALKQFRLPVEETELEKRLIVDDTSTRWSENMKHFTPSTL A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN CTTRISPNTSQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTL Q5HY69_HUMAN Q5HY69_HUMAN CTTRISPNTSQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTL FA8_CANFA FA8_CANFA STTRMSSNASQH-VITQRGKRSLKQPRLSQGEIKFERKVIANDTSTQWSKNMNYLAQGTL B2KIK9_RHIFE B2KIK9_RHIFE STTRISPNPSQRNAMDQRGKRALKQFSSPKEETKLKMGVILNDTSTQWSKNMNYLTQGTL MATCH CONSENSUS ?????????SQ??????R?K??L?Q???????????????????ST??????????????

Q7TN96_RAT Q7TN96_RAT KQIDHRKERKKFIIESRSADSSG-TKSPTQTNHSPSHVVKMSAFP---PRDIRRIESRD- FA8_MOUSE FA8_MOUSE KQIDHSKEMKKFITKSSLSDSSV-IKSTTQTNSSDSHIVKTSAFP---PIDLKRSPFQNK B7ZNH8_MOUSE B7ZNH8_MOUSE KQIDHSKEMKKFITKSSLSDSSV-IKSTTQTNSSDSHIVKTSAFP---PIDLKRSPFQNK A2AN88_MOUSE A2AN88_MOUSE KQIDHSKEMKKFITKSSLSDSSV-IKSTTQTNSSDSHIVKTSAFP---PIDLKRSPFQNK B2RRC9_MOUSE B2RRC9_MOUSE KQIDHSKEMKKFITKSSLSDSSV-IKSTTQTNSSDSHIVKTSAFP---PIDLKRSPFQNK FA8_PIG FA8_PIG ------------------------------------------------------------ B1PL82_RABIT B1PL82_RABIT TRMNCNEK-KKVVTQSPTSDGPLRSHNIIHMNGSVLPTANLSVFPSIRPTDLTKIPSQNS B7NZR5_RABIT B7NZR5_RABIT TQMNCNEK-KKVVTQSPTSDGPLRSHNIIHMNGSVLPTANLSVFPSIRPTDLTKIPSQNN B0KWU5_CALJA B0KWU5_CALJA TKIDVNEKDKGAVTQSPLSDCLTRNHSITQ--------AKVSLLPSISPIDLTRVPFQNN A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN TQIDYNEKEKGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDN Q5HY69_HUMAN Q5HY69_HUMAN TQIDYNEKEKGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDN FA8_CANFA FA8_CANFA TQIEYNEKEKRAITQSPLSDCSMRNHVTIQMNDSALPVAKESASPSVRHTDLTKIPSQHN B2KIK9_RHIFE B2KIK9_RHIFE TPIEYNEKETGAITQSFIDDS-MRSHGIIQMDGSALPVAKVSALPSIRPTDLTKIPSQDN MATCH CONSENSUS ???????????????S???D?????????????????????S??P???????????????

Q7TN96_RAT Q7TN96_RAT SSQVWVSSYAYDFETGSSRIRESSPFLNETETDNPSLAVPPRERFVRRGRFASPEKVNTH FA8_MOUSE FA8_MOUSE FSHVQASSYIYDFKTKSSRIQESNNFLKETKINNPSLAILPWNMFIDQGKFTSPGKSNTN B7ZNH8_MOUSE B7ZNH8_MOUSE FSHVQASSYIYDFKTKSSRIQESNNFLKETKINNPSLAILPWNMFIDQGKFTSPGKSNTN A2AN88_MOUSE A2AN88_MOUSE FSHVQASSYIYDFKTKSSRIQESNNFLKETKINNPSLAILPWNMFIDQGKFTSPGKSNTN B2RRC9_MOUSE B2RRC9_MOUSE FSHVQASSYIYDFKTKSSRIQESNNFLKETKINNPSLAILPWNMFIDQGKFTSPGKSNTN FA8_PIG FA8_PIG ---------------------ESSPILQGAKRNNLSLPFLTLEMAGGQGKISALGKSAAG B1PL82_RABIT B1PL82_RABIT SPHLLTPAYNYKFMERSPGVQKNNHLLQDAKKNNLSSAILPLEVVRDQEKVGSLGTSATN B7NZR5_RABIT B7NZR5_RABIT SPHLLTPAYNYKFMERSPGVQKNNHLLQDAKKNNLSLAILPLEVVRDQEKVGSLGTSATN B0KWU5_CALJA B0KWU5_CALJA SSHLLALSY----RKKNSGVQESSRILQGAKENNLSLAILTLEMIGDQREVGSVGTSATN A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN SSHLPAASY----RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATN Q5HY69_HUMAN Q5HY69_HUMAN SSHLPAASY----RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATN FA8_CANFA FA8_CANFA SSHLPASACNYTFRERTSGVQEGSHFLQEAKRNNLSLAFVTLGITEGQGKFSSLGKSATN B2KIK9_RHIFE B2KIK9_RHIFE SSHLLASAYSYTFRERSSGAQESNHFLQGAKR-NLSLAFLTLEMTGGQEKISSLGEGATN MATCH CONSENSUS ??????????????????????????L???K??N?SLA?????????Q????S?G???T?

Q7TN96_RAT Q7TN96_RAT SAPCDKPENVVSSEPVSPGEAVTVALPPHVSTQEEEPLPAGSSCERRGHVDLFLEISLQR FA8_MOUSE FA8_MOUSE SVTYKKRENIIFLKPTLPEESGKIELLPQVSIQEEEILPTETSHGSPGHLNLMKEVFLQK B7ZNH8_MOUSE B7ZNH8_MOUSE SVTYKKRENIIFLKPTLPEESGKIELLPQVSIQEEEILPTETSHGSPGHLNLMKEVFLQK A2AN88_MOUSE A2AN88_MOUSE SVTYKKRENIIFLKPTLPEESGKIELLPQVSIQEEEILPTETSHGSPGHLNLMKEVFLQK B2RRC9_MOUSE B2RRC9_MOUSE SVTYKKRENIIFLKPTLPEESGKIELLPQVSIQEEEILPTETSHGSPGHLNLMKEVFLQK FA8_PIG FA8_PIG PLASGKLEKAVLSSAGLSEASGKAEFLPKVRVHREDLLPQKTSNVSCAHGDLGQEIFLQK B1PL82_RABIT B1PL82_RABIT SVMYKKFDNVVLLKPGLPEASSNVELLPKVPIHQEDPFSEVTSNGSPDHLDLVEES-PQK B7NZR5_RABIT B7NZR5_RABIT SVMYKKFDNVVLLKPGLPEASSNVELLPKVPIHQEDLFSEVTSNGSPDHLDLVEES-LQK B0KWU5_CALJA B0KWU5_CALJA SVMYEKLENTILLKPGLPKTSGKVELFPKVHIYQKDFLPAETTNRSPGHLDLMEGSLLQE A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN SVTYKKVENTVLPKPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQG Q5HY69_HUMAN Q5HY69_HUMAN SVTYKKVENTVLPKPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQG FA8_CANFA FA8_CANFA QPMYKKLENTVLLQPGLSETSDKVELLSQVHVDQEDSFPTKTSNDSPGHLDLMGKIFLQK B2KIK9_RHIFE B2KIK9_RHIFE PLIHKKLENTVLLKPGLSKASGQVELLPNVHVHQENSFPTKTSNASPGYVDLIEEIFLQT MATCH CONSENSUS ?????K??N?????P?L???S???EL?P?V???????????TS??S??H??L?????LQ?

Q7TN96_RAT Q7TN96_RAT TRGPVERSRGRRSGGD--TEGHTENPGKTPSPL-----------PQMPKDQRGSEAGYPK FA8_MOUSE FA8_MOUSE IQGPTKWNKAKRHGES--IKGKTESSKNTRSKLLNHHAWDYHYAAQIPKDMWKSKEKSPE B7ZNH8_MOUSE B7ZNH8_MOUSE IQGPTKWNKAKRHGES--IKGKTESSKNTRSKLLNHHAWDYHYAAQIPKDMWKSKEKSPE A2AN88_MOUSE A2AN88_MOUSE IQGPTKWNKAKRHGES--IKGKTESSKNTRSKLLNHHAWDYHYAAQIPKDMWKSKEKSPE B2RRC9_MOUSE B2RRC9_MOUSE IQGPTKWNKAKRHGES--IKGKTESSKNTRSKLLNHHAWDYHYAAQIPKDMWKSKEKSPE FA8_PIG FA8_PIG TRGPVNLNKVNRPG-------------RTPSKLLGPP---------MPKE-WESLEKSPK B1PL82_RABIT B1PL82_RABIT TQGAVKWNKVNRPGKVLFLKEAAENPEKTPSKLMMPLVWDNQYVTQTPKKECKSQEKSPK B7NZR5_RABIT B7NZR5_RABIT TQGAVKWNKVNRPGKVLFLKEAAENPEKTPSKLMMPLVWDNQYVTQTPKKECKSQEKSPK B0KWU5_CALJA B0KWU5_CALJA TEGANKWNEANRPGKIPFLRGVTESSAKTPSKLLGSLAWDNYYGTQISKEEWKSQEKSPE A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN TEGAIKWNEANRPGKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPE Q5HY69_HUMAN Q5HY69_HUMAN TEGAIKWNEANRPGKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPE FA8_CANFA FA8_CANFA TQGPVKMNKTNSPGKVPFLKWATESSEKIPSKLLGVLAWDNHYDTQIPSEEWKSQKKSQT B2KIK9_RHIFE B2KIK9_RHIFE TQEPVQLNQVNRPGKVPFLKWTTKSSENTSSKLLVPPGWDSQYATQIPREEWKSQEKSQK MATCH CONSENSUS ??G????N???R?G??????????????T?SKL????????????Q?P?????S??KS??

Q7TN96_RAT Q7TN96_RAT ICRWR-DGTV-LPPRPH--NLSLGA-KKKPNLPRREATRVEQGEAPSLVSPEPLVLRRRP FA8_MOUSE FA8_MOUSE IISIKQEDTI-LSLRPHGNSHSIGA-NEKQNWPQRETTWVKQGQTQRTCSQIPPVLKRHQ B7ZNH8_MOUSE B7ZNH8_MOUSE IISIKQEDTI-LSLRPHGNSHSIGA-NEKQNWPQRETTWVKQGQTQRTCSQIPPVLKRHQ A2AN88_MOUSE A2AN88_MOUSE IISIKQEDTI-LSLRPHGNSHSIGA-NEKQNWPQRETTWVKQGQTQRTCSQIPPVLKRHQ B2RRC9_MOUSE B2RRC9_MOUSE IISIKQEDTI-LSLRPHGNSHSIGA-NEKQNWPQRETTWVKQGQTQRTCSQIPPVLKRHQ FA8_PIG FA8_PIG STALRTKDIISLPLDRHESNHSIAAKNEGQAETQREAAWTKQGGPGRLCAPKPPVLRRHQ B1PL82_RABIT B1PL82_RABIT NTDFKTKDSI-LSLTPCENNYAIETMNEGQDRLPREASWAKQGGTGSLCSQNPSDLIHQE B7NZR5_RABIT B7NZR5_RABIT NTDFKTKDSI-LSLTPCENNYAIETMNEGQDRLPREASWAKQGGTGSLCSQNPSDLIHQE B0KWU5_CALJA B0KWU5_CALJA NTAFKIKDTI-LSLNPCESNHAIPAINEGQNKPQIEVTWAKQSETERLCSQHPPVLKRHQ A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN KTAFKKKDTI-LSLNACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQ Q5HY69_HUMAN Q5HY69_HUMAN KTAFKKKDTI-LSLNACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQ FA8_CANFA FA8_CANFA NTAFKRKDTI-LPLGPCENNDSTAAINEGQDKPQREAMWAKQGEPGRLCSQNPPVSKHHQ B2KIK9_RHIFE B2KIK9_RHIFE DIAFKTTDTI-SPLDPRENNHSIPAINEGQDKAQREATWAKSGGTGRLSFQSPPVLTGHQ MATCH CONSENSUS ???????D?I?L?L????????????NE?Q?????E??W?KQG?????????P??L????

Q7TN96_RAT Q7TN96_RAT REASTLLPGGEMREDDGDGVTAEYDDDDDVMAEYDDDAVTVDTPEDFDIYGEEAGQGPRG FA8_MOUSE FA8_MOUSE RELS------------------AFQSEQEAT-DYDDAITIETI-EDFDIYSEDIKQGPRS B7ZNH8_MOUSE B7ZNH8_MOUSE RELS------------------AFQSEQEAT-DYDDAITIETI-EDFDIYSEDIKQGPRS A2AN88_MOUSE A2AN88_MOUSE RELS------------------AFQSEQEAT-DYDDAITIETI-EDFDIYSEDIKQGPRS B2RRC9_MOUSE B2RRC9_MOUSE RELS------------------AFQSEQEAT-DYDDAITIETI-EDFDIYSEDIKQGPRS FA8_PIG FA8_PIG RDIS----------------LPTFQPEEDKM-DYDDIFSTETKGEDFDIYGEDENQDPRS B1PL82_RABIT B1PL82_RABIT RKIT----------------LTTIQSQQEEI-YYDDTISSEIKREDFDIYGEDEIQGPRS B7NZR5_RABIT B7NZR5_RABIT RKIT----------------LTTIQSQQEEI-YYDDTISSEIKREDFDIYGEDEIQGPRS B0KWU5_CALJA B0KWU5_CALJA EEI-----------------------------DYDDTISTEMKKEDFDIYGEDENQSPRN A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN REIT----------------RTTLQSDQEEI-DYDDTISVEMKKEDFDIYDEDENQSPRS Q5HY69_HUMAN Q5HY69_HUMAN REIT----------------RTTLQSDQEEI-DYDDTISVEMKKEDFDIYDEDENQSPRS FA8_CANFA FA8_CANFA REIT----------------VTTLQPEEDKF-EYDDTFSIEMKREDFDIYGDYENQGLRS B2KIK9_RHIFE B2KIK9_RHIFE REIP----------------LTTPQPDEDKT-DYDDTFSTEMKREDFDIYGEDENQGPRS MATCH CONSENSUS R????????????????????????????????YDD????E???EDFDIY?E???Q?PR?

Q7TN96_RAT Q7TN96_RAT FQQKTRHYFIAAVEELWDYGVRVSPGALGDRAWSGDAARFRKVVFREFTDGSFTQRVHRG FA8_MOUSE FA8_MOUSE FQQKTRHYFIAAVERLWDYGMSTS-HVLRNRYQSDNVPQFKKVVFQEFTDGSFSQPLYRG B7ZNH8_MOUSE B7ZNH8_MOUSE FQQKTRHYFIAAVERLWDYGMSTS-HVLRNRYQSDNVPQFKKVVFQEFTDGSFSQPLYRG A2AN88_MOUSE A2AN88_MOUSE FQQKTRHYFIAAVERLWDYGMSTS-HVLRNRYQSDNVPQFKKVVFQEFTDGSFSQPLYRG B2RRC9_MOUSE B2RRC9_MOUSE FQQKTRHYFIAAVERLWDYGMSTS-HVLRNRYQSDNVPQFKKVVFQEFTDGSFSQPLYRG FA8_PIG FA8_PIG FQKRTRHYFIAAVEQLWDYGMSESPRALRNRAQNGEVPRFKKVVFREFADGSFTQPSYRG B1PL82_RABIT B1PL82_RABIT FQKRTRHYFIAAVERLWDYGMSTSPHALRNSVQ------FKKVVFQEFTDGSFTQPLYRG B7NZR5_RABIT B7NZR5_RABIT FQKRTRHYFIAAVERLWDYGMSTSPHALRNSVQ------FKKVVFQEFTDGSFTQPLYRG B0KWU5_CALJA B0KWU5_CALJA FQKKTRHYFIAAVERLWDYGLSSSLHVLRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRG A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN FQKKTRHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRG Q5HY69_HUMAN Q5HY69_HUMAN FQKKTRHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRG FA8_CANFA FA8_CANFA FQKKTRHYFIAAVERLWDYGMSRSPHILRNRAQSGDVQQFKKVVFQEFTDGSFTQPLYRG B2KIK9_RHIFE B2KIK9_RHIFE FQKRTRHYFIAAVERLWDYGMGKSLYALRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRG MATCH CONSENSUS FQ??TRHYFIAAVE?LWDYG???S???LRN??Q??????FKKVVF?EFTDGSF?QP?YRG

Q7TN96_RAT Q7TN96_RAT ELDAHLGLLGPYIRAEVEDNIVVTFRNQASRPYSFYSSLVSYPEADG-GAAPRSNFVRPN FA8_MOUSE FA8_MOUSE ELNEHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYKEDQR-GEEPRRNFVKPN B7ZNH8_MOUSE B7ZNH8_MOUSE ELNEHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYKEDQR-GEEPRRNFVKPN A2AN88_MOUSE A2AN88_MOUSE ELNEHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYKEDQR-GEEPRRNFVKPN B2RRC9_MOUSE B2RRC9_MOUSE ELNEHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYKEDQR-GEEPRRNFVKPN FA8_PIG FA8_PIG ELNKHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYPDDQEQGAEPRHNFVQPN B1PL82_RABIT B1PL82_RABIT ELNEHLGILGPYIRAEVEDNIVVTFKNMASRPYSFYSSLISYKDDQRQGAEPRKNFVKPN B7NZR5_RABIT B7NZR5_RABIT ELNEHLGILGPYIRAEVEDNIVVTFKNMASRPYSFYSSLISYKDDQRQGAEPRKNFVKPN B0KWU5_CALJA B0KWU5_CALJA ELNEHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYEEDQRQGAEPRQTFVKPN A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN ELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGAEPRKNFVKPN Q5HY69_HUMAN Q5HY69_HUMAN ELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGAEPRKNFVKPN FA8_CANFA FA8_CANFA ELNEHLGLLGPYIRAEVEDNIVVTFKNQASRPYSFYSSLISYDEDEGQGAEPRRKFVNPN B2KIK9_RHIFE B2KIK9_RHIFE ELNEHLGLLGPCIRAEVEDNIMVTFKNEASRPYSFYSSLISYEEDESQGAQPRQKFVKPN MATCH CONSENSUS ELN?HLG?LGPYIRAEVEDNI?VTF?N?ASRPYSFYSSLISY??D???G??PR??FV?PN

Q7TN96_RAT Q7TN96_RAT ETKTYFWRVRPHMAPTDGEFDCKAWAYFSDVDLERDLHSGLIGPLLVCHASTLHPSHARP FA8_MOUSE FA8_MOUSE ETKIYFWKVQHHMAPTEDEFDCKAWAYFSDVDLERDMHSGLIGPLLICHANTLNPAHGRQ B7ZNH8_MOUSE B7ZNH8_MOUSE ETKIYFWKVQHHMAPTEDEFDCKAWAYFSDVDLERDMHSGLIGPLLICHANTLNPAHGRQ A2AN88_MOUSE A2AN88_MOUSE ETKIYFWKVQHHMAPTEDEFDCKAWAYFSDVDLERDMHSGLIGPLLICHANTLNPAHGRQ B2RRC9_MOUSE B2RRC9_MOUSE ETKIYFWKVQHHMAPTEDEFDCKAWAYFSDVDLERDMHSGLIGPLLICHANTLNPAHGRQ FA8_PIG FA8_PIG ETRTYFWKVQHHMAPTEDEFDCKAWAYFSDVDLEKDVHSGLIGPLLICRANTLNAAHGRQ B1PL82_RABIT B1PL82_RABIT ETKTYFWEVQHHMAPTKDEFDCKAWAYFSDVDLEKDMHSGLIGPLLICHTNTLNPAHGRQ B7NZR5_RABIT B7NZR5_RABIT ETKTYFWEVQHHMAPTKDEFDCKAWAYFSDVDLEKDMHSGLIGPLLICHTNTLNPAHGRQ B0KWU5_CALJA B0KWU5_CALJA ETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQ A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN ETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQ Q5HY69_HUMAN Q5HY69_HUMAN ETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQ FA8_CANFA FA8_CANFA ETKIYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLICRSNTLNPAHGRQ B2KIK9_RHIFE B2KIK9_RHIFE ETKIYFWKVQHHMAPTKDEFDCKAWAYFSDVDLERDMHSGLIGPLLICRTNTLNPSHGRQ MATCH CONSENSUS ETK?YFW?VQHHMAPT?DEFDCKAWAYFSDVDLE?D?HSGLIGPLL?C??NTLNP?HGRQ

Q7TN96_RAT Q7TN96_RAT LAVQEFALLFAVFDETKSWYCAENLDRKCRPPRGTPAGDPAWREEYRFHAVNGYVADALL FA8_MOUSE FA8_MOUSE VSVQEFALLFTIFDETKSWYFTENVKRNCKTPCNFQMEDPTLKENYRFHAINGYVMDTLP B7ZNH8_MOUSE B7ZNH8_MOUSE VSVQEFALLFTIFDETKSWYFTENVKRNCKTPCNFQMEDPTLKENYRFHAINGYVMDTLP A2AN88_MOUSE A2AN88_MOUSE VSVQEFALLFTIFDETKSWYFTENVKRNCKTPCNFQMEDPTLKENYRFHAINGYVMDTLP B2RRC9_MOUSE B2RRC9_MOUSE VSVQEFALLFTIFDETKSWYFTENVKRNCKTPCNFQMEDPTLKENYRFHAINGYVMDTLP FA8_PIG FA8_PIG VTVQEFALFFTIFDETKSWYFTENVERNCRAPCHLQMEDPTLKENYRFHAINGYVMDTLP B1PL82_RABIT B1PL82_RABIT VTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQTEDPTFKENYRFHAINGYVMDTLP B7NZR5_RABIT B7NZR5_RABIT VTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQTEDPTFKENYRFHAINGYVMDTLP B0KWU5_CALJA B0KWU5_CALJA VTVQEFALFFTIFDETKSWYFTENMERNCRPPCNVQMEDPTFKENYRFHAING------- A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN VTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHAINGYIMDTLP Q5HY69_HUMAN Q5HY69_HUMAN VTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHAINGYIMDTLP FA8_CANFA FA8_CANFA VTVQEFALVFTIFDETKSWYFTENLERNCRAPCNVQKEDPTLKENFRFHAINGYVKDTLP B2KIK9_RHIFE B2KIK9_RHIFE VTVREFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPAFKQNYRFHAINGYVMDTLP MATCH CONSENSUS V?VQEFAL?FTIFDETKSWYFTEN??RNC??PC??Q?EDP??KENYRFHAINGY??D?L?

Q7TN96_RAT Q7TN96_RAT GLVMAEGRRTRWHLLSMGDPGHAQSVHFSAHSVTVRDGGEHRTAVCNLYPGVFTTVEMLP FA8_MOUSE FA8_MOUSE GLVMAQDQRIRWYLLSMGNNENIQSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETLEMIP B7ZNH8_MOUSE B7ZNH8_MOUSE GLVMAQDQRIRWYLLSMGNNENIQSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETLEMIP A2AN88_MOUSE A2AN88_MOUSE GLVMAQDQRIRWYLLSMGNNENIQSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETLEMIP B2RRC9_MOUSE B2RRC9_MOUSE GLVMAQDQRIRWYLLSMGNNENIQSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETLEMIP FA8_PIG FA8_PIG GLVMAQNQRIRWYLLSMGSNENIHSIHFSGHVFSVRKKEEYKMAVYNLYPGVFETVEMLP B1PL82_RABIT B1PL82_RABIT GLVMAQDQRIRWYLLSMCSNENIHSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETVEMLP B7NZR5_RABIT B7NZR5_RABIT GLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETVEMLP B0KWU5_CALJA B0KWU5_CALJA ------------------------------------------------------------ A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN GLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFETVEMLP Q5HY69_HUMAN Q5HY69_HUMAN GLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFETVEMLP FA8_CANFA FA8_CANFA GLVMAQDQKVRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETVEMLP B2KIK9_RHIFE B2KIK9_RHIFE GLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETVEMQP MATCH CONSENSUS GLVMA?????RW?LLSM???????S?HFS?H???VR???E???A??NLYPGVF?T?EM?P

Q7TN96_RAT Q7TN96_RAT SRAGIWRVESLVGEHLRAGMSALFLVYSTRCQVPLGMASGYIRDSQITASGYHGLWTPQL FA8_MOUSE FA8_MOUSE SRAGIWRVECLIGEHLQAGMSTLFLVYSKQCQIPLGMASGSIRDFQITASGHYGQWAPNL B7ZNH8_MOUSE B7ZNH8_MOUSE SRAGIWRVECLIGEHLQAGMSTLFLVYSKQCQIPLGMASGSIRDFQITASGHYGQWAPNL A2AN88_MOUSE A2AN88_MOUSE SRAGIWRVECLIGEHLQAGMSTLFLVYSKQCQIPLGMASGSIRDFQITASGHYGQWAPNL B2RRC9_MOUSE B2RRC9_MOUSE SRAGIWRVECLIGEHLQAGMSTLFLVYSKQCQIPLGMASGSIRDFQITASGHYGQWAPNL FA8_PIG FA8_PIG SKVGIWRIECLIGEHLQAGMSTTFLVYSKECQAPLGMASGRIRDFQITASGQYGQWAPKL B1PL82_RABIT B1PL82_RABIT SKAGIWRVECLIGEHLHAGMSTLFLVYSKNCQIPLGMASGHIQDFQITASGQYGQWAPKL B7NZR5_RABIT B7NZR5_RABIT SKAGIWRVECLIGEHLHAGMSTLFLVYSKNCQIPLGMASGHIQDFQITASGQYGQWAPKL B0KWU5_CALJA B0KWU5_CALJA ------------------------------------------------------------ A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN SKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKL Q5HY69_HUMAN Q5HY69_HUMAN SKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKL FA8_CANFA FA8_CANFA SQVGIWRIECLIGEHLQAGMSTLFLVYSKKCQTPLGMASGHIRDFQITASGQYGQWAPKL B2KIK9_RHIFE B2KIK9_RHIFE SKAGIWRIECLIGEHLQAGMSTLFLVYSKKCQTPLGMASGRIRDFQITASGQYGQWAPKL MATCH CONSENSUS S??GIWR?E?L?GEHL?AGMS??FLVYS??CQ?PLGMASG?I?D?QITASG??G?W?P?L

Q7TN96_RAT Q7TN96_RAT ARLHNAGSVNAWSAKEPFAWIKVDLLAPMILHGIETQGARHRLSSLYVSQFIIMYSLDGK FA8_MOUSE FA8_MOUSE ARLHYSGSINAWSTKEPFSWIKVDLLAPMIVHGIKTQGARQKFSSLYISQFIIMYSLDGK B7ZNH8_MOUSE B7ZNH8_MOUSE ARLHYSGSINAWSTKEPFSWIKVDLLAPMIVHGIKTQGARQKFSSLYISQFIIMYSLDGK A2AN88_MOUSE A2AN88_MOUSE ARLHYSGSINAWSTKEPFSWIKVDLLAPMIVHGIKTQGARQKFSSLYISQFIIMYSLDGK B2RRC9_MOUSE B2RRC9_MOUSE ARLHYSGSINAWSTKEPFSWIKVDLLAPMIVHGIKTQGARQKFSSLYISQFIIMYSLDGK FA8_PIG FA8_PIG ARLHYSGSINAWSTKDPHSWIKVDLLAPMIIHGIMTQGARQKFSSLYISQFIIMYSLDGR B1PL82_RABIT B1PL82_RABIT ARLHYSGSINAWSTKDPFSWIKVDLLTPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGK B7NZR5_RABIT B7NZR5_RABIT ARLHYSGSINAWSTKDPFSWIKVDLLTPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGK B0KWU5_CALJA B0KWU5_CALJA ------------------------------------------------------------ A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN ARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGK Q5HY69_HUMAN Q5HY69_HUMAN ARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGK FA8_CANFA FA8_CANFA ARLHYSGSINAWSTKDPFSWIKVDLLAPMIIHGIMTQGARQKFSSLYVSQFIIMYSLDGN B2KIK9_RHIFE B2KIK9_RHIFE ARLHHSGSINAWSTKDPFSWIKVDLLAPMIIHGIMTQGARQKFSSLYISQFIIMYSLDGS MATCH CONSENSUS ARLH??GS?NAWS?K?P??WIKVDLL?PMI?HGI?TQGAR???SSLY?SQFIIMYSLDG?

Q7TN96_RAT Q7TN96_RAT QWLSYRGNSTGSLMVFFGNVDASTVRHNRFDPPIVARYIRVHPTHASIRTALRMELLGCD FA8_MOUSE FA8_MOUSE KWLSYQGNSTGTLMVFFGNVDSSGIKHNSFNPPIIARYIRLHPTHSSIRSTLRMELMGCD B7ZNH8_MOUSE B7ZNH8_MOUSE KWLSYQGNSTGTLMVFFGNVDSSGIKHNSFNPPIIARYIRLHPTHSSIRSTLRMELMGCD A2AN88_MOUSE A2AN88_MOUSE KWLSYQGNSTGTLMVFFGNVDSSGIKHNSFNPPIIARYIRLHPTHSSIRSTLRMELMGCD B2RRC9_MOUSE B2RRC9_MOUSE KWLSYQGNSTGTLMVFFGNVDSSGIKHNSFNPPIIARYIRLHPTHSSIRSTLRMELMGCD FA8_PIG FA8_PIG NWQSYRGNSTGTLMVFFGNVDASGIKHNIFNPPIVARYIRLHPTHYSIRSTLRMELMGCD B1PL82_RABIT B1PL82_RABIT KWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIAQYIRLHPTHYSIRSTLRMELIGCD B7NZR5_RABIT B7NZR5_RABIT KWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIAQYIRLHPTHYSIRSTLRMELIGCD B0KWU5_CALJA B0KWU5_CALJA ------------------------------------------------------------ A8KA37_HUMAN A8KA37_HUMAN ------------------------------------------------------------ FA8_HUMAN FA8_HUMAN KWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCD Q5HY69_HUMAN Q5HY69_HUMAN KWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCD FA8_CANFA FA8_CANFA KWHSYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIAQYIRLHPTHYSIRSTLRMELLGCD B2KIK9_RHIFE B2KIK9_RHIFE KWQSYRGNSTGTLM