Alignment of the gene Family HBG107140 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
B9EK93_MOUSE B9EK93_MOUSE ASCSFSGHQALRRLRASAAAAASAALAAVATTPLLSSGTRTALIGTGSSCPGAMWLSTAT IRS4_MOUSE IRS4_MOUSE ASCSFSGHQALRRLRASAAAAASAALAAVATTPLLSSGTRTALIGTGSSCPGAMWLSTAT IRS4_HUMAN IRS4_HUMAN ASCSFTRDQATRRLRG-AAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT MATCH *****: .** ****. *****:******.********* ******************** CONSENSUS ASCSF???QA?RRLR??AAAAA?AALAAV?TTPLLSSGT?TALIGTGSSCPGAMWLSTAT

B9EK93_MOUSE B9EK93_MOUSE GSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYRNARKFRH IRS4_MOUSE IRS4_MOUSE GSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYRNARKFRH IRS4_HUMAN IRS4_HUMAN GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH MATCH ****************:***********************************.******* CONSENSUS GSRSDSESEEEDLPVG?EVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYY?NARKFRH

B9EK93_MOUSE B9EK93_MOUSE SVRAAAAAAEAAASGAAVPALIPPRRVIILYQCFSVSQRADARYRHLIALFTQDEYFAMV IRS4_MOUSE IRS4_MOUSE SVRAAAAAAEAAASGAAVPALIPPRRVIILYQCFSVSQRADARYRHLIALFTQDEYFAMV IRS4_HUMAN IRS4_HUMAN SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV MATCH ********* *******:*.******** ******************************* CONSENSUS SVRAAAAAA?AAASGAA?P?LIPPRRVI?LYQCFSVSQRADARYRHLIALFTQDEYFAMV

B9EK93_MOUSE B9EK93_MOUSE AENESEQESWYLLLSRLILESKRRRCGTLGALPDGEPAALAAAAAAEPPFYKDVWQVVVK IRS4_MOUSE IRS4_MOUSE AENESEQESWYLLLSRLILESKRRRCGTLGALPDGEPAALAAAAAAEPPFYKDVWQVVVK IRS4_HUMAN IRS4_HUMAN AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK MATCH ******************************* *************************:** CONSENSUS AENESEQESWYLLLSRLILESKRRRCGTLGA?PDGEPAALAAAAAAEPPFYKDVWQV?VK

B9EK93_MOUSE B9EK93_MOUSE PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST IRS4_MOUSE IRS4_MOUSE PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST IRS4_HUMAN IRS4_HUMAN PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST MATCH ************************************************************ CONSENSUS PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST

B9EK93_MOUSE B9EK93_MOUSE VIGPGELWMQVDDSVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSTRRH IRS4_MOUSE IRS4_MOUSE VIGPGELWMQVDDSVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSTRRH IRS4_HUMAN IRS4_HUMAN VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH MATCH *************.******************************************:*** CONSENSUS VIGPGELWMQVDD?VVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLS?RRH

B9EK93_MOUSE B9EK93_MOUSE LGLLPLEPGGWLRRYGLEQFCRLRAIRERE-EMLFTRRFISPREPPPPFRRGRGHLPRAR IRS4_MOUSE IRS4_MOUSE LGLLPLEPGGWLRRYGLEQFCRLRAIRERE-EMLFTRRFISPREPPPPFRRGRGHLPRAR IRS4_HUMAN IRS4_HUMAN LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR MATCH ***:********** :****:**** : * ********::* ** . **** ****.* CONSENSUS LGL?PLEPGGWLRR???EQFC?LRAI???E?EMLFTRRF??P?EP????RRGR?HLPR?R

B9EK93_MOUSE B9EK93_MOUSE RSRRAASVPPSLFRRSAPSPGRIPQPEDVPNDRAR---EASGSSSGNTEE----KDKEGE IRS4_MOUSE IRS4_MOUSE RSRRAASVPPSLFRRSAPSPGRIPQPEDVPNDRAR---EASGSSSGNTEE----KDKEGE IRS4_HUMAN IRS4_HUMAN RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ MATCH *****.***.*:*** ****.* :* :.**: ** *.***.*** * :.**.: CONSENSUS RSRRA?SVP?S?FRR?APSP?R???P???PN??AR???E?SGS?SGN??E??????KE??

B9EK93_MOUSE B9EK93_MOUSE EGNRGDCIPMNNWGSGNGRGSGGGRGSSGQGSSSQGSGGRQGSG------GGQGSGGQGA IRS4_MOUSE IRS4_MOUSE EGNRGDCIPMNNWGSGNGRGSGGGRGSSGQGSSSQGSGGRQGSG------GGQGSGGQGA IRS4_HUMAN IRS4_HUMAN EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS MATCH **. ** :****************:**.******:.***.* ** *****.***: CONSENSUS EG??GD??PMNNWGSGNGRGSGGG?GS?GQGSSS??SGG?Q?SG??????GGQGS?GQG?

B9EK93_MOUSE B9EK93_MOUSE GGNQCSGNGQGTAGGHGSG-----GGGHGSGGGQRPGDGHGSGGGKNSGSGKNS------ IRS4_MOUSE IRS4_MOUSE GGNQCSGNGQGTAGGHGSG-----GGGHGSGGGQRPGDGHGSGGGKNSGSGKNS------ IRS4_HUMAN IRS4_HUMAN GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS MATCH ****** :*********** ********** **************.**.* CONSENSUS GGNQCS??GQGTAGGHGSG?????GGGHGSGGGQ?PGDGHGSGGGKNSG?GK?S??????

B9EK93_MOUSE B9EK93_MOUSE -DDGDRGKSVKKRSYFGKFTQSKQQQTL--PPPPPPPPAAGATGGKGKSGGRFRLYFCAD IRS4_MOUSE IRS4_MOUSE -DDGDRGKSVKKRSYFGKFTQSKQQQTL--PPPPPPPPAAGATGGKGKSGGRFRLYFCAD IRS4_HUMAN IRS4_HUMAN DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD MATCH .**:****:********:******* ********.**.****************.* CONSENSUS ??DG?RGKS?KKRSYFGK?TQSKQQQ????PPPPPPPP?AG?TGGKGKSGGRFRLYFC?D

B9EK93_MOUSE B9EK93_MOUSE RG-TKERKEAKEVRDMETPGGATRGPYRARAFDEDEDDPYVPMRPGVAAPLACSSDYMPM IRS4_MOUSE IRS4_MOUSE RG-TKERKEAKEVRDMETSGGATRGPYRARAFDEDEDDPYVPMRPGVAAPLACSSDYMPM IRS4_HUMAN IRS4_HUMAN RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM MATCH ** *** ******:* * . **:***:*********************:**..******* CONSENSUS RG?TKE?KEAKEV?D?E???GA?RGP?RARAFDEDEDDPYVPMRPGVA?PL??SSDYMPM

B9EK93_MOUSE B9EK93_MOUSE APQNSSASTKRHSRSPFEDSRGYMMMFPRVSPPPPVPSAPKAPDTNKGDDSKDNDSDSDY IRS4_MOUSE IRS4_MOUSE APQNSSASTKRHSRSPFEDSRGYMMMFPRVSPPPPVPSAPKAPDTNKGDDSKDNDSDSDY IRS4_HUMAN IRS4_HUMAN APQNVSASKKRHSRSPFEDSRGYMMMFPRVS-PPPAPSPPKAPDTNKEDDSKDNDSESDY MATCH **** ***.********************** ***.**.******** ********:*** CONSENSUS APQN?SAS?KRHSRSPFEDSRGYMMMFPRVS?PPP?PS?PKAPDTNK?DDSKDNDS?SDY

B9EK93_MOUSE B9EK93_MOUSE MFMAPGAGAIPKNPPNAQGGSSSKSWSSYFSLPSPFQSSPLGQSDHSEYVPMLPGKFLGS IRS4_MOUSE IRS4_MOUSE MFMAPGAGAIPKNPPNAQGGSSSKSWSSYFSLPSPFQSSPLGQSDHSEYVPMLPGKFLGS IRS4_HUMAN IRS4_HUMAN MFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGR MATCH ************** *.****************.**:******.*:************* CONSENSUS MFMAPGAGAIPKNP?N?QGGSSSKSWSSYFSLP?PF?SSPLGQ?D?SEYVPMLPGKFLG?

B9EK93_MOUSE B9EK93_MOUSE GLHKEASFSQGTKNVSSKPSTEASFSKPEDKGSSAKPSDDVPPMNKAKEPNHLSFIAKGT IRS4_MOUSE IRS4_MOUSE GLHKEASFSQGTKNVSSKPSTEASFSKPEDKGSSAKPSDDVPPMNKAKEPNHLSFIAKGT IRS4_HUMAN IRS4_HUMAN GLDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGY MATCH **.**.*:. ..*:.:**** *.***** * **.:****. ** ****.**:****:** CONSENSUS GL?KE?S?????K???SKPS?E?SFSKP?D?GS??KPSD??PP?NKAK?PN?LSFI?KG?

B9EK93_MOUSE B9EK93_MOUSE QVKPKPLNPTQERREAAGSRDYINIDFIKRERLVLPSSAQGLPDMRGVVTDPAPTAFSGY IRS4_MOUSE IRS4_MOUSE QVKPKPLNPTQERREAAGSRDYINIDFIKRERLVLPSSAQGLPDMRGVVTDPAPTAFSGY IRS4_HUMAN IRS4_HUMAN KIKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNY MATCH ::**** :**:*:*** .* **:*:** *** . ..*:***** *::::* :***.* CONSENSUS ??KPKP??PT?E?REA??S?DY?N?DF?KRE??????S?QGLPD??G????P???AFS?Y

B9EK93_MOUSE B9EK93_MOUSE LNVEFGVPFPNPTIRLSDLLRVLPGANSIPLAGTRWPFPG---SAIGS--IVEAGEYIEV IRS4_MOUSE IRS4_MOUSE LNVEFGVPFPNPTIRLSDLLRVLPGANSIPLAGTRWPFPG---SAIGS--IVEAGEYIEV IRS4_HUMAN IRS4_HUMAN VNVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEV MATCH :***********: ******.:* **.:.* .:***:* ** ** * * *:**** CONSENSUS ?NVEFGVPFPNP???LSDLLR??P?AN???L???RWP?P????SA?GS??I?E?G?YIEV

B9EK93_MOUSE B9EK93_MOUSE IFNPAMTPAMSFADSAICYDAQTGQIYVVDPFSECCMDVSLSPGRCSEPPPVARLRREEA IRS4_MOUSE IRS4_MOUSE IFNPAMTPAMSFADSAICYDAQTGQIYVVDPFSECCMDVSLSPGRCSEPPPVARLRREEA IRS4_HUMAN IRS4_HUMAN IFNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEE MATCH ***.******::***** ***:**:*************:****.*********** :** CONSENSUS IFN?AMTPAM??ADSAI?YDA?TG?IYVVDPFSECCMD?SLSP?RCSEPPPVARL??EE?

B9EK93_MOUSE B9EK93_MOUSE QERRRPQSRSQSLFASTRAAVSAFPTDSLDRDFPAASAVIAAPAEAPLLAVSRALAVVSA IRS4_MOUSE IRS4_MOUSE QERRRPQSRSQSLFASTRAAVSAFPTDSLDRDFPAASAVIAAPAEAPLLAVSRALAVVSA IRS4_HUMAN IRS4_HUMAN QERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASA MATCH ************:**::************:**:..:** .*.* * **:*:.:*..** CONSENSUS QERRRPQSRSQS?FA??RAAVSAFPTDSL?RD????SA???A?A??P?LA?S???A??SA

B9EK93_MOUSE B9EK93_MOUSE LAAAPSIGDVFAGFRAAAGVDSASARGFQPVAG---AQAVREFQDLAAGWNPGALNHG-- IRS4_MOUSE IRS4_MOUSE LAAAPSIGDVFAGFRAAAGVDSASARGFQPVAG---AQAVREFQDLAAGWNPGALNHR-- IRS4_HUMAN IRS4_HUMAN LAAAPGIGAA----AAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSAN MATCH *****.** . ****.****** *****. *:*** **:*.* **** * CONSENSUS LAAAP?IG???????AAAG?DSASAR?FQPVA????A?AVR??QD?A?G?NPGA?N????

B9EK93_MOUSE B9EK93_MOUSE -ARGEDLAAG----AAAPPPPPRQIWVLRPQERADSEDDDDDDDDIYVRMDFARRDYR-- IRS4_MOUSE IRS4_MOUSE -ARGEDLAAG----AAAPPPPPRQIWVLRPQERADSEDDDDDDDDIYVRMDFARRDYR-- IRS4_HUMAN IRS4_HUMAN LARGDNQAGGAAAAAAAPEPPPRSRRVPRPPER----EDSDNDDDTHVRMDFARRDNQFD MATCH ***:: *.* **** ****. * ** ** :*.*:*** :********* : CONSENSUS ?ARG???A?G????AAAP?PPPR???V?RP?ER?????D?D?DDD??VRMDFARRD????

B9EK93_MOUSE B9EK93_MOUSE -----K IRS4_MOUSE IRS4_MOUSE -----K IRS4_HUMAN IRS4_HUMAN SPKRGR MATCH : CONSENSUS ??????


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