Alignment of the gene Family HBG107487 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q7SZL3_XENLA Q7SZL3_XENLA -------MPTLNPSYSVGVPNT-------------------------------------- Q9PTB1_CHICK Q9PTB1_CHICK ------------------------------------------------------------ 5HT2B_MOUSE 5HT2B_MOUSE -------MASSYKMSEQSTTSE-----------HILQKTCDHLI---------------L 5HT2B_RAT 5HT2B_RAT -------MASSYKMSEQSTISE-----------HILQKTCDHLI---------------L O46636_CANFA O46636_CANFA ------------------------------------------------------------ Q50DZ8_CANFA Q50DZ8_CANFA -------MAISYRISEQSTIPE-----------HILQSSFHHLI---------------F A3RL34_CAVPO A3RL34_CAVPO -------MAFSYRMSEQSKIPK-----------HVLQSTLGGLI---------------S 5HT2B_HUMAN 5HT2B_HUMAN -------MALSYRVSELQSTIP----------EHILQSTFVHVI---------------S B3VRC5_HUMAN B3VRC5_HUMAN ------------------------------------------------------------ B3VRC8_9PRIM B3VRC8_9PRIM ------------------------------------------------------------ B3VRC9_PONPY B3VRC9_PONPY ------------------------------------------------------------ B3VRC6_PANPA B3VRC6_PANPA ------------------------------------------------------------ B3VRC7_PANTR B3VRC7_PANTR ------------------------------------------------------------ 5HT2B_TETFL 5HT2B_TETFL -----MFQAAVGPLQTNISLPE-------------------------------------- Q0GH74_DANRE Q0GH74_DANRE -------MANVR-----------------------------------------------Q Q62842_RAT Q62842_RAT ------------------------------------------------------------ 5HT2C_RAT 5HT2C_RAT -------MVNLGNAVRSLLMHL----------IGLLVWQFDISISPVAAI---------V 5HT2C_MOUSE 5HT2C_MOUSE -------MVNLGTAVRSLLVHL----------IGLLVWQFDISISPVAAI---------V B2RUD4_MOUSE B2RUD4_MOUSE -------MVNLGTAVRSLLVHL----------IGLLVWQFDISISPVAAI---------V B1ATN5_MOUSE B1ATN5_MOUSE -------MVNLGTAVRSLLVHL----------IGLLVWQFDISISPVAAI---------V Q8BZI5_MOUSE Q8BZI5_MOUSE -------MVNLGTAVRSLLVHL----------IGLLVWQFDISISPVAAI---------V 5HT2C_CANFA 5HT2C_CANFA -------MVNLRKAVHSFLVHL----------IGLLVWQCDISVSPVAAL---------V Q5ISA4_9PRIM Q5ISA4_9PRIM -----------RNAVHSFLVHL----------IGLLVWQCDISVSPVAAL---------V B3VRE4_PONPY B3VRE4_PONPY ------------------------------------------------------------ B3VRE3_9PRIM B3VRE3_9PRIM ------------------------------------------------------------ 5HT2C_PANTR 5HT2C_PANTR -------MVNLRNAVHSFLVHL----------IGLLVWQCDISVSPVAAI---------V 5HT2C_HUMAN 5HT2C_HUMAN -------MVNLRNAVHSFLVHL----------IGLLVWQCDISVSPVAAI---------V B3VRE0_HUMAN B3VRE0_HUMAN ------------------------------------------------------------ B3VRE2_PANTR B3VRE2_PANTR ------------------------------------------------------------ B3VRE1_PANPA B3VRE1_PANPA ------------------------------------------------------------ B2WSB2_DANRE B2WSB2_DANRE MMGAPGGPVLGGFSSTTSSLDL----------VGWMIWPGNTTVSLNQSFFG-------T B8JHQ2_DANRE B8JHQ2_DANRE MMGAPGGPVLGGFSSTTSSLDL----------VGWMIWPGNTTVSLNQSFFG-------T B3V8C3_9SAUR B3V8C3_9SAUR -------MSAINGAGVLVGFTTVSVTLDFSLHKNLMAWPLNHNLTLNQSLP--------T B0S6G9_DANRE B0S6G9_DANRE ------------------------------------------------------------ B9VWH1_9TELE B9VWH1_9TELE SLRGGNMSDWIPTTVRTVKHLETNPWPPRVLEEGIIRHGGNSSVTNPGCHGSDAAPNAVE B3V8C2_9SAUR B3V8C2_9SAUR -------MDVIYAGEKSLNPTA----------HYLL-LDQGRKLYRNASFSGEIN----K 5HT2A_BOVIN 5HT2A_BOVIN -------MDILCEENTSLSSTT----------NSLMQLHADTRLYSTDFNSGEGN----T O97565_SHEEP O97565_SHEEP ------------------------------------------------------------ Q0EAB4_HORSE Q0EAB4_HORSE -------MDILCEENTSLSSTT----------NSLMQLNDDTRLYNSNFHSGDTN----T 5HT2A_PIG 5HT2A_PIG -------MDVLCEENTSLSSPT----------NSFMQLNDDTRLYHNDFNSGEAN----T 5HT2A_CANFA 5HT2A_CANFA -------MDVLFEDNAPLSPTT----------SSLMPSNGDPRLYGNDLNAGDAN----T 5HT2A_HUMAN 5HT2A_HUMAN -------MDILCEENTSLSSTT----------NSLMQLNDDTRLYSNDFNSGEAN----T B4DZ79_HUMAN B4DZ79_HUMAN -------MQFLKSAKQKPNYYH-------------------------------------- B3VRB0_HUMAN B3VRB0_HUMAN ------------------------------------------------------------ B3VRB3_9PRIM B3VRB3_9PRIM ------------------------------------------------------------ Q9N2F3_9PRIM Q9N2F3_9PRIM ------------------------------------------------------------ Q9P2Q9_HUMAN Q9P2Q9_HUMAN ------------------------------------------------------------ B3VRB1_PANPA B3VRB1_PANPA ------------------------------------------------------------ B3VRB2_PANTR B3VRB2_PANTR ------------------------------------------------------------ Q9N2F4_PANTR Q9N2F4_PANTR ------------------------------------------------------------ Q5ISK8_MACFA Q5ISK8_MACFA ---------------TSLSSTT----------NSLMQLNEDTRLYSNDFNSGEAN----T 5HT2A_MACMU 5HT2A_MACMU -------MDILCEENTSLSSTT----------NSLMQLNEDTRLYSNDFNSGEAN----T 5HT2A_PONPY 5HT2A_PONPY -------MDILCEENTSLSSTT----------NSLMQLNDDTRLYSNDFNSGEAN----T B3VRB4_PONPY B3VRB4_PONPY ------------------------------------------------------------ 5HT2A_RAT 5HT2A_RAT -------MEILCEDNISLSSIP----------NSLMQLGDGPRLYHNDFNSRDAN----T 5HT2A_MOUSE 5HT2A_MOUSE -------MEILCEDNISLSSIP----------NSLMQLGDDSRLYPNDFNSRDAN----T Q543D4_MOUSE Q543D4_MOUSE -------MEILCEDNISLSSIP----------NSLMQLGDDSRLYPNDFNSRDAN----T 5HT2A_CAVPO 5HT2A_CAVPO ------------------------------------------------------------ Q4U3W9_MESAU Q4U3W9_MESAU -------MEILCEDNTSLSSIP----------NSLMQLDGDSRLYHNDFNSRDAN----S 5HT2A_CRIGR 5HT2A_CRIGR -------MEILCEDNTSLSSIP----------NSLMQVDGDSGLYRNDFNSRDAN----S Q9QW77_CRIGR Q9QW77_CRIGR -------MEILCEDNTSLSSIP----------NSLMQVDGDSGLYRNDFNSRDAN----S MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q7SZL3_XENLA Q7SZL3_XENLA ----------------------------TASVAVPEKCWLALLTLMVIVPTIGGNILVIM Q9PTB1_CHICK Q9PTB1_CHICK ------------------------------------------------------------ 5HT2B_MOUSE 5HT2B_MOUSE TNRSGLETDSVAEEM-----------KQTVEGQGHTVHWAALLILAVIIPTIGGNILVIL 5HT2B_RAT 5HT2B_RAT TDRSGLKAESAAEEM-----------KQTAENQGNTVHWAALLIFAVIIPTIGGNILVIL O46636_CANFA O46636_CANFA ------------------------------------------------------------ Q50DZ8_CANFA Q50DZ8_CANFA ANWSGLQTESIPEEM-----------KQTGEQQGKKPQWAALLILTVIIPTIGGNILVIL A3RL34_CAVPO A3RL34_CAVPO SNWSRFQKGSIPEEM-----------KQTFEEQGNKLNWAALLILMVIIPTIGGNILVIL 5HT2B_HUMAN 5HT2B_HUMAN SNWSGLQTESIPEEM-----------KQIVEEQGNKLHWAALLILMVIIPTIGGNTLVIL B3VRC5_HUMAN B3VRC5_HUMAN ------------------------------------------------------------ B3VRC8_9PRIM B3VRC8_9PRIM ------------------------------------------------------------ B3VRC9_PONPY B3VRC9_PONPY ------------------------------------------------------------ B3VRC6_PANPA B3VRC6_PANPA ------------------------------------------------------------ B3VRC7_PANTR B3VRC7_PANTR ------------------------------------------------------------ 5HT2B_TETFL 5HT2B_TETFL ------------------------------ETPGLELNWAALLIVMVIIPTIGGNILVIL Q0GH74_DANRE Q0GH74_DANRE TDSVDWPS-----------------------------HWAALLILLVIVPTIGGNILVIL Q62842_RAT Q62842_RAT --------------------------MCYFQLRPSCTSAP-------------------- 5HT2C_RAT 5HT2C_RAT TDTFNSSDG-----------------GRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIM 5HT2C_MOUSE 5HT2C_MOUSE TDTFNSSDG-----------------GRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIM B2RUD4_MOUSE B2RUD4_MOUSE TDTFNSSDG-----------------GRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIM B1ATN5_MOUSE B1ATN5_MOUSE TDTFNSSDG-----------------GRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIM Q8BZI5_MOUSE Q8BZI5_MOUSE TDTFNSSDG-----------------GRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIM 5HT2C_CANFA 5HT2C_CANFA TDIFNTSD------------------GGRFKFPDGVQNWPALSIVIIIILTIGGNILVIM Q5ISA4_9PRIM Q5ISA4_9PRIM TDIFNTSD------------------GGRFKFPDGVQNWPALAIVIIIIMTIGGNILVIM B3VRE4_PONPY B3VRE4_PONPY ------------------------------------------------------------ B3VRE3_9PRIM B3VRE3_9PRIM ------------------------------------------------------------ 5HT2C_PANTR 5HT2C_PANTR TDIFNTSD------------------GGRFKFPDGVQNWPALSIVVIIIMTIGGNILVIM 5HT2C_HUMAN 5HT2C_HUMAN TDIFNTSD------------------GGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIM B3VRE0_HUMAN B3VRE0_HUMAN ------------------------------------------------------------ B3VRE2_PANTR B3VRE2_PANTR ------------------------------------------------------------ B3VRE1_PANPA B3VRE1_PANPA ------------------------------------------------------------ B2WSB2_DANRE B2WSB2_DANRE DYSFNLSSSSSSSP------------HGVKREEMKEKNWPALLILVIIILTIEGNILVIL B8JHQ2_DANRE B8JHQ2_DANRE DYSFNLSSSSSSSP------------HGVKREEMKEKNWPALLILVIIILTIGGNILVIL B3V8C3_9SAUR B3V8C3_9SAUR PDPLNVSEG-----------------TGVSQMPLKEKNWPALLILIIILLTIGGNILVIM B0S6G9_DANRE B0S6G9_DANRE ----------------------------------VRKNWAALLILVVVIVTVAGNILVIM B9VWH1_9TELE B9VWH1_9TELE AHVGNWSYGEEEAG------------LYGSLCPPGQKNWAALLILIVVAVTVMGNILVIL B3V8C2_9SAUR B3V8C2_9SAUR PHGCNMTSHSEEVMNCSHRGNLIPIISSTSLLHLHEKNWPALLTVIVIIVTIAGNILVIM 5HT2A_BOVIN 5HT2A_BOVIN SNAFNWTVDSENRTNLSCEGCLSP--PCFSLLHLQEKNWSALLTAVVIILTIAGNILVIM O97565_SHEEP O97565_SHEEP ------------------------------------------------------------ Q0EAB4_HORSE Q0EAB4_HORSE SDAFNWTVDSENRTNLSCEGCLSP--PCLSLLHLQEKNWSALLTTVVIILTIAGNILVIM 5HT2A_PIG 5HT2A_PIG SDAFNWTVDSENRTNLSCEGCLSP--PCFSLLHLQEKNWSALLTAVVIILTIAGNILVIM 5HT2A_CANFA 5HT2A_CANFA SDAFNWTVDAENRTNLSCEGCLSP--PCFSLLHLQEKNWSALLTAVVIILTIAGNILVIM 5HT2A_HUMAN 5HT2A_HUMAN SDAFNWTVDSENRTNLSCEGCLSP--SCLSLLHLQEKNWSALLTAVVIILTIAGNILVIM B4DZ79_HUMAN B4DZ79_HUMAN ---------------------------------------------------------IML B3VRB0_HUMAN B3VRB0_HUMAN ------------------------------------------------------------ B3VRB3_9PRIM B3VRB3_9PRIM ------------------------------------------------------------ Q9N2F3_9PRIM Q9N2F3_9PRIM ------------------------------------------------------------ Q9P2Q9_HUMAN Q9P2Q9_HUMAN ------------------------------------------------------------ B3VRB1_PANPA B3VRB1_PANPA ------------------------------------------------------------ B3VRB2_PANTR B3VRB2_PANTR ------------------------------------------------------------ Q9N2F4_PANTR Q9N2F4_PANTR ------------------------------------------------------------ Q5ISK8_MACFA Q5ISK8_MACFA SDAFNWTVDSENRTNLSCEGCLSP--SCLSLLHLQEKNWSALLTAVVIILTIAGNILVIM 5HT2A_MACMU 5HT2A_MACMU SDAFNWTVESENRTNLSCEGCLSP--SCLSLLHLQEKNWSALLTAVVIILTIAGNILVIM 5HT2A_PONPY 5HT2A_PONPY SDAFNWTVDSENRTNLSCEGCLSP--SCLSLLHLQEKNWSALLTAVVIILTIAGNILVIM B3VRB4_PONPY B3VRB4_PONPY ------------------------------------------------------------ 5HT2A_RAT 5HT2A_RAT SEASNWTIDAENRTNLSCEGYLPP--TCLSILHLQEKNWSALLTTVVIILTIAGNILVIM 5HT2A_MOUSE 5HT2A_MOUSE SEASNWTIDAENRTNLSCEGYLPP--TCLSILHLQEKNWSALLTTVVIILTIAGNILVIM Q543D4_MOUSE Q543D4_MOUSE SEASNWTIDAENRTNLSCEGYLPP--TCLSILHLQEKNWSALLTTVVIILTIAGNILVIM 5HT2A_CAVPO 5HT2A_CAVPO ------------------------------------------------------------ Q4U3W9_MESAU Q4U3W9_MESAU SDASNWTIDAENRTNLSCEGYLPP--TCLSILHLQEKNWSALLTTVVIILTIAGNILVIM 5HT2A_CRIGR 5HT2A_CRIGR SDASNWTIDGENRTNLSFEGYLPP--TCLSILHLQEKNWSALLTAVVIILTIAGNILVIM Q9QW77_CRIGR Q9QW77_CRIGR SDASNWTIDGENRTNLSFEGYLPP--TCLSILHLQEKNWSAILTAVVIILTIAGNILVIM MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q7SZL3_XENLA Q7SZL3_XENLA AISLEKKLQNATNYFLMSLAVADLLVGIFVMPVALINILFNQVWQLPQCVCAIWLFLDVL Q9PTB1_CHICK Q9PTB1_CHICK ------------------------------------------------------------ 5HT2B_MOUSE 5HT2B_MOUSE AVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVL 5HT2B_RAT 5HT2B_RAT AVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVL O46636_CANFA O46636_CANFA ------------------------------------------------------------ Q50DZ8_CANFA Q50DZ8_CANFA AISLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFETIWPLPLVLCPAWLFLDVL A3RL34_CAVPO A3RL34_CAVPO AVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVL 5HT2B_HUMAN 5HT2B_HUMAN AVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVL B3VRC5_HUMAN B3VRC5_HUMAN ------------------------------------------------------------ B3VRC8_9PRIM B3VRC8_9PRIM ------------------------------------------------------------ B3VRC9_PONPY B3VRC9_PONPY ------------------------------------------------------------ B3VRC6_PANPA B3VRC6_PANPA ------------------------------------------------------------ B3VRC7_PANTR B3VRC7_PANTR ------------------------------------------------------------ 5HT2B_TETFL 5HT2B_TETFL AVWLEKKLQNATNFFLMSLAVADLLVGLLVMPIALITILYDSDWPLPEPLCPIWLFLDVL Q0GH74_DANRE Q0GH74_DANRE AVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTVLYNSTWPLADFLCPIWLFLDVL Q62842_RAT Q62842_RAT -----------------------------------------YRW---------------- 5HT2C_RAT 5HT2C_RAT AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL 5HT2C_MOUSE 5HT2C_MOUSE AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL B2RUD4_MOUSE B2RUD4_MOUSE AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL B1ATN5_MOUSE B1ATN5_MOUSE AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL Q8BZI5_MOUSE Q8BZI5_MOUSE AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL 5HT2C_CANFA 5HT2C_CANFA AVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL Q5ISA4_9PRIM Q5ISA4_9PRIM AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL B3VRE4_PONPY B3VRE4_PONPY ------------------------------------------------------------ B3VRE3_9PRIM B3VRE3_9PRIM ------------------------------------------------------------ 5HT2C_PANTR 5HT2C_PANTR AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL 5HT2C_HUMAN 5HT2C_HUMAN AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVL B3VRE0_HUMAN B3VRE0_HUMAN ------------------------------------------------------------ B3VRE2_PANTR B3VRE2_PANTR ------------------------------------------------------------ B3VRE1_PANPA B3VRE1_PANPA ------------------------------------------------------------ B2WSB2_DANRE B2WSB2_DANRE AVSLEKKLQNATNFFLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCPIWIYLDVL B8JHQ2_DANRE B8JHQ2_DANRE AVSLEKKLQNATNFFLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCPIWIYLDVL B3V8C3_9SAUR B3V8C3_9SAUR AVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLITILYDSDWPLPKQLCPIWISLDVL B0S6G9_DANRE B0S6G9_DANRE AVNLERKLQNATNYFLMSLAVADMLLGLLVMPVSMVTIVYGYSWPFPASLCPMWIYLDVL B9VWH1_9TELE B9VWH1_9TELE AVSLEKKLQNATNYFLMSLAVADMLLGILVMPVSMVTILYDYGWPLPSDLCPIWIYLDVL B3V8C2_9SAUR B3V8C2_9SAUR AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYEYTWPLPRNLCAVWIYLDVL 5HT2A_BOVIN 5HT2A_BOVIN AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVL O97565_SHEEP O97565_SHEEP ------------------------------------------------------------ Q0EAB4_HORSE Q0EAB4_HORSE AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVL 5HT2A_PIG 5HT2A_PIG AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL 5HT2A_CANFA 5HT2A_CANFA AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL 5HT2A_HUMAN 5HT2A_HUMAN AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL B4DZ79_HUMAN B4DZ79_HUMAN VEDQEEGTLHQFNYCERCSESQNNKCISCVNPEDKW-----YRWPLPSKLCAVWIYLDVL B3VRB0_HUMAN B3VRB0_HUMAN ------------------------------------------------------------ B3VRB3_9PRIM B3VRB3_9PRIM ------------------------------------------------------------ Q9N2F3_9PRIM Q9N2F3_9PRIM ------------------------------------------------------------ Q9P2Q9_HUMAN Q9P2Q9_HUMAN ------------------------------------------------------------ B3VRB1_PANPA B3VRB1_PANPA ------------------------------------------------------------ B3VRB2_PANTR B3VRB2_PANTR ------------------------------------------------------------ Q9N2F4_PANTR Q9N2F4_PANTR ------------------------------------------------------------ Q5ISK8_MACFA Q5ISK8_MACFA AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL 5HT2A_MACMU 5HT2A_MACMU AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL 5HT2A_PONPY 5HT2A_PONPY AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL B3VRB4_PONPY B3VRB4_PONPY ------------------------------------------------------------ 5HT2A_RAT 5HT2A_RAT AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVL 5HT2A_MOUSE 5HT2A_MOUSE AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL Q543D4_MOUSE Q543D4_MOUSE AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL 5HT2A_CAVPO 5HT2A_CAVPO ------------------------------------------------KLCAIWIYLDVL Q4U3W9_MESAU Q4U3W9_MESAU AVSLEKKLRNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL 5HT2A_CRIGR 5HT2A_CRIGR AVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL Q9QW77_CRIGR Q9QW77_CRIGR AVSLEKKIQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPIPSKLCAVWIYLDVI MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q7SZL3_XENLA Q7SZL3_XENLA FSTASIMHLCAISLDRYIAIKKPIQASQYNSRGKTLIKITVVWVISAGIAFPIPIKGL-- Q9PTB1_CHICK Q9PTB1_CHICK -----------------------------NSWATTIIKITIVWLISIGIAIPVPIRGI-- 5HT2B_MOUSE 5HT2B_MOUSE FSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGI-- 5HT2B_RAT 5HT2B_RAT FSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGI-- O46636_CANFA O46636_CANFA -----------------------------------------VWLISIGIAIPVPIRGI-- Q50DZ8_CANFA Q50DZ8_CANFA FSTASIMHLCAISVDRYIAIKKPIQANQSNSRATAFIKITVVWLISIGIAIPVPIRGI-- A3RL34_CAVPO A3RL34_CAVPO FSTASILHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGI-- 5HT2B_HUMAN 5HT2B_HUMAN FSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGI-- B3VRC5_HUMAN B3VRC5_HUMAN ------------------------------------------------IAIPVPIKGI-- B3VRC8_9PRIM B3VRC8_9PRIM ------------------------------------------------IAIPVPIKGI-- B3VRC9_PONPY B3VRC9_PONPY ------------------------------------------------IAIPVPIKGI-- B3VRC6_PANPA B3VRC6_PANPA ------------------------------------------------IAIPVPIKGI-- B3VRC7_PANTR B3VRC7_PANTR ------------------------------------------------IAIPVPIKGI-- 5HT2B_TETFL 5HT2B_TETFL FSTASIMHLCAISLDRYIAIKKPIQHSQYKSRAKVMLKIALVWLISICIAIPIPIKGL-- Q0GH74_DANRE Q0GH74_DANRE FSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVWLISIGIAIPIPIKGLQF Q62842_RAT Q62842_RAT ----------------------------------------------TGVSVPIPVIGL-- 5HT2C_RAT 5HT2C_RAT FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- 5HT2C_MOUSE 5HT2C_MOUSE FSTASIMHLCAISLDRYVAVRSPVEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- B2RUD4_MOUSE B2RUD4_MOUSE FSTASIMHLCAISLDRYVAVRNPVEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- B1ATN5_MOUSE B1ATN5_MOUSE FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- Q8BZI5_MOUSE Q8BZI5_MOUSE FSTASIMHLCAISLDRYVAVRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- 5HT2C_CANFA 5HT2C_CANFA FSTASIMHLCAISLDRYVAIRNPVEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- Q5ISA4_9PRIM Q5ISA4_9PRIM FSTASIMHLCAISLDRYVAIRNPXEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- B3VRE4_PONPY B3VRE4_PONPY ------------------------------------------------VSVPIPVIGL-- B3VRE3_9PRIM B3VRE3_9PRIM ------------------------------------------------VSVPIPVIGL-- 5HT2C_PANTR 5HT2C_PANTR FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- 5HT2C_HUMAN 5HT2C_HUMAN FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL-- B3VRE0_HUMAN B3VRE0_HUMAN ------------------------------------------------VSVPIPVIGL-- B3VRE2_PANTR B3VRE2_PANTR ------------------------------------------------VSVPIPVIGL-- B3VRE1_PANPA B3VRE1_PANPA ------------------------------------------------VSVPIPVIGL-- B2WSB2_DANRE B2WSB2_DANRE FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMLKIAAVWTISIGISMPIPVIGL-- B8JHQ2_DANRE B8JHQ2_DANRE FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMLKIAAVWTISIGISMPIPVIGL-- B3V8C3_9SAUR B3V8C3_9SAUR FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAAVWTISIGISSPVPVIGL-- B0S6G9_DANRE B0S6G9_DANRE FSTASIMHLCAISLDRYVAIRNPIRHNRSNSRSRARAKITAVWTISAGISMPIPVLGL-- B9VWH1_9TELE B9VWH1_9TELE FSTASIMHLCAISLDRYIAIRNPIHHSRFNSHTKARLKIMAVWTISVGISMPIPVLGL-- B3V8C2_9SAUR B3V8C2_9SAUR FSTASIMHLCAISLDRYIAIQNPIHHSRFNSRTKAFAKIIAVWTISMGISMPVPVFGL-- 5HT2A_BOVIN 5HT2A_BOVIN FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- O97565_SHEEP O97565_SHEEP -------------LDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- Q0EAB4_HORSE Q0EAB4_HORSE FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTRAFLKIIAVWTISVGISMPVPVFGL-- 5HT2A_PIG 5HT2A_PIG FSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- 5HT2A_CANFA 5HT2A_CANFA FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- 5HT2A_HUMAN 5HT2A_HUMAN FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- B4DZ79_HUMAN B4DZ79_HUMAN FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- B3VRB0_HUMAN B3VRB0_HUMAN ------------------------------------------------ISMPIPVFGL-- B3VRB3_9PRIM B3VRB3_9PRIM ------------------------------------------------ISMPIPVFGL-- Q9N2F3_9PRIM Q9N2F3_9PRIM ------------------------------------------------------------ Q9P2Q9_HUMAN Q9P2Q9_HUMAN ------------------------------------------------------------ B3VRB1_PANPA B3VRB1_PANPA ------------------------------------------------ISMPIPVFGL-- B3VRB2_PANTR B3VRB2_PANTR ------------------------------------------------ISMPIPVFGL-- Q9N2F4_PANTR Q9N2F4_PANTR ------------------------------------------------------------ Q5ISK8_MACFA Q5ISK8_MACFA FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- 5HT2A_MACMU 5HT2A_MACMU FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- 5HT2A_PONPY 5HT2A_PONPY FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- B3VRB4_PONPY B3VRB4_PONPY ------------------------------------------------ISMPIPVFGL-- 5HT2A_RAT 5HT2A_RAT FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- 5HT2A_MOUSE 5HT2A_MOUSE FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- Q543D4_MOUSE Q543D4_MOUSE FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- 5HT2A_CAVPO 5HT2A_CAVPO FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPVPVFGL-- Q4U3W9_MESAU Q4U3W9_MESAU FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGL-- 5HT2A_CRIGR 5HT2A_CRIGR FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGVSMPIPVFGL-- Q9QW77_CRIGR Q9QW77_CRIGR FSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGVSMPIPVFGL-- MATCH CONSENSUS ???????????????????????????????????????????????????P?P??G???

Q7SZL3_XENLA Q7SZL3_XENLA -LD----PNTTFSASYTCVIQVEPFKYFIIYGSMAAFFVPFGIMVVIYFLTIHLLRKKAY Q9PTB1_CHICK Q9PTB1_CHICK -E-----DGNGNSTNITCLLTPDRFHDFILYGSVAAFFIPLAIMIVTYFLTIQVLRKKAY 5HT2B_MOUSE 5HT2B_MOUSE -ET----D-VINPHNVTCELTKDRFGSFMVFGSLAAFFVPLTIMVVTYFLTIHTLQKKAY 5HT2B_RAT 5HT2B_RAT -EA----D-VVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAY O46636_CANFA O46636_CANFA -ET----D-RSNPSNITCVLTKDRFGNFMLYGSLAAFFTPLAIMIVTYFLTIRALQKKAS Q50DZ8_CANFA Q50DZ8_CANFA -ET----D-RSNPSNITCVLTKDRFGNFMLYGSLAAFFTPLAIMIVTYFLTIRALQKKAS A3RL34_CAVPO A3RL34_CAVPO --D----TDVPNPNNITCALTKERFGNFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY 5HT2B_HUMAN 5HT2B_HUMAN -ET----D-VDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY B3VRC5_HUMAN B3VRC5_HUMAN -ET----D-VDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY B3VRC8_9PRIM B3VRC8_9PRIM -ET----D-VDNPNNITCVLTKERFGNFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY B3VRC9_PONPY B3VRC9_PONPY -ET----D-VDNPNNITCVLTKERFGNFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY B3VRC6_PANPA B3VRC6_PANPA -ET----D-VDNPNNITCVLTKERFGNFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY B3VRC7_PANTR B3VRC7_PANTR -ET----D-VDNPNNITCVLTKERFGNFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY 5HT2B_TETFL 5HT2B_TETFL -RNYPHPNNITFTSNHTCVLKTDTFQEFIIFGSLVAFFIPLTIMMIIYFLTVRVLRKKVY Q0GH74_DANRE Q0GH74_DANRE FDH----PNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIPLAIMMIIYLLTIQVLRKKAY Q62842_RAT Q62842_RAT -RD----ESKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTL 5HT2C_RAT 5HT2C_RAT -RD----ESKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTL 5HT2C_MOUSE 5HT2C_MOUSE -RD----ESKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTL B2RUD4_MOUSE B2RUD4_MOUSE -RD----ESKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTL B1ATN5_MOUSE B1ATN5_MOUSE -RD----ESKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTL Q8BZI5_MOUSE Q8BZI5_MOUSE -RD----ESKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTL 5HT2C_CANFA 5HT2C_CANFA -RD----EEKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIHVLRRQAL Q5ISA4_9PRIM Q5ISA4_9PRIM -RD----EEKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL B3VRE4_PONPY B3VRE4_PONPY -RD----EDKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL B3VRE3_9PRIM B3VRE3_9PRIM -RD----EEKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL 5HT2C_PANTR 5HT2C_PANTR -RD----ERKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL 5HT2C_HUMAN 5HT2C_HUMAN -RD----EEKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL B3VRE0_HUMAN B3VRE0_HUMAN -RD----EEKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL B3VRE2_PANTR B3VRE2_PANTR -RD----EEKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL B3VRE1_PANPA B3VRE1_PANPA -RD----EEKVFVNNTTCVLNDPN---FVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAL B2WSB2_DANRE B2WSB2_DANRE -SN----REKVLKNG-ICALNEEL---FILVGSFVAFFIPLVIMVVTYCLTVQALQRQAT B8JHQ2_DANRE B8JHQ2_DANRE -SN----REKVLKNG-ICALNEEL---FILVGSFVAFFIPLVIMVVTYCLTVQALQRQAT B3V8C3_9SAUR B3V8C3_9SAUR -QD----NSRVFVNG-RCVLNDEN---FILFGSFVAFFIPLIIMVFAYCLTIRVLQKQAS B0S6G9_DANRE B0S6G9_DANRE -RD----HTKVFKDG-SCLLTDNS---FVLIGSFVAFFVPLTIMVVTYFLTISALQSEAT B9VWH1_9TELE B9VWH1_9TELE -RD----HSKVFKDG-SCLLTDNN---FVLVGSFVAFFIPLTIMVITYFLTINALQNEAT B3V8C2_9SAUR B3V8C2_9SAUR -HD----DSKIFNNG-SCLLMDDN---FVLIGSFVAFFVPLAIMVITYCLTIRSLQKQVT 5HT2A_BOVIN 5HT2A_BOVIN -QD----DSKVFKEG-SCLLADEN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT O97565_SHEEP O97565_SHEEP -QD----DSKVFKEG-SCLLADEN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT Q0EAB4_HORSE Q0EAB4_HORSE -QD----DSKVFKEG-SCLLADDN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_PIG 5HT2A_PIG -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_CANFA 5HT2A_CANFA -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_HUMAN 5HT2A_HUMAN -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT B4DZ79_HUMAN B4DZ79_HUMAN -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT B3VRB0_HUMAN B3VRB0_HUMAN -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT B3VRB3_9PRIM B3VRB3_9PRIM -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT Q9N2F3_9PRIM Q9N2F3_9PRIM -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT Q9P2Q9_HUMAN Q9P2Q9_HUMAN -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT B3VRB1_PANPA B3VRB1_PANPA -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT B3VRB2_PANTR B3VRB2_PANTR -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT Q9N2F4_PANTR Q9N2F4_PANTR -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT Q5ISK8_MACFA Q5ISK8_MACFA -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_MACMU 5HT2A_MACMU -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_PONPY 5HT2A_PONPY -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT B3VRB4_PONPY B3VRB4_PONPY -QD----DSKVFKEG-SCLLADDN---FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_RAT 5HT2A_RAT -QD----DSKVFKEG-SCLLADDN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_MOUSE 5HT2A_MOUSE -QD----DSKVFKEG-SCLLADDN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT Q543D4_MOUSE Q543D4_MOUSE -QD----DSKVFKEG-SCLLADDN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_CAVPO 5HT2A_CAVPO -QD----DSKVFKEG-SCLLADDN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT Q4U3W9_MESAU Q4U3W9_MESAU -QD----DSKVFKEG-SCLLADDN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT 5HT2A_CRIGR 5HT2A_CRIGR -QD----DSKVFKQG-SCLLADDN---FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEAT Q9QW77_CRIGR Q9QW77_CRIGR -QD----DSKVFKQG-SCLLADDN---FVLIGSFVAFFIPITIMVITYFLTIKSLQKEAT MATCH . * : * : **..:** *: **:. * **: *: :. CONSENSUS ?????????????????C?L???????F?L?GS???FF?PL?IM??TY?LTI??L???A?

Q7SZL3_XENLA Q7SZL3_XENLA LIKNK------------------PPQRLTWS---TVSTVFQR--------DATPGSSPEK Q9PTB1_CHICK Q9PTB1_CHICK LI-NK------------------PPQRFTWS---TVSTVFQR--------DATPACSPEK 5HT2B_MOUSE 5HT2B_MOUSE LVKNK------------------PPQRLTRW---TVPTVFLR--------EDSSFSSPEK 5HT2B_RAT 5HT2B_RAT LVRNR------------------PPQRLTRW---TVSTVLQR--------EDSSFSSPEK O46636_CANFA O46636_CANFA LVKNK------------------PPPCLTWL---TVSTAFRR--------NETPCSSPEK Q50DZ8_CANFA Q50DZ8_CANFA LVKNK------------------PPPCLTWL---TVSTAFRR--------NETPCSSPEK A3RL34_CAVPO A3RL34_CAVPO LLKNK------------------APQSLTWL---NVSTVFQR--------DETPSSSPEK 5HT2B_HUMAN 5HT2B_HUMAN LVKNK------------------PPQRLTWL---TVSTVFQR--------DETPCSSPEK B3VRC5_HUMAN B3VRC5_HUMAN LVKNK------------------PPQRLTWL---TVSTVFQR--------DETPCSSPEK B3VRC8_9PRIM B3VRC8_9PRIM LVKNK------------------PPQRLTWL---TVSTVFQR--------DETPCSSPEK B3VRC9_PONPY B3VRC9_PONPY LVKNK------------------PPQRLTWL---TVSTVFQR--------DETPCSSPEK B3VRC6_PANPA B3VRC6_PANPA LVKNK------------------PPQRLTWL---TVSTVFQR--------DETPCSSPEK B3VRC7_PANTR B3VRC7_PANTR LVKNK------------------PPQRLTWL---TVSTVFQR--------DETPCSSPEK 5HT2B_TETFL 5HT2B_TETFL LLRSK------------------VTQRFSYP---IISTVFQREQAANPPQPEQPDSTGNS Q0GH74_DANRE Q0GH74_DANRE LLRSR-------------------AARP------SISTVFQQ--------ELSVLASPEK Q62842_RAT Q62842_RAT MLLRG-----------------HTEEELANM---SLN--FLNCCCKKNGGEEENAPNPNP 5HT2C_RAT 5HT2C_RAT MLLRG-----------------HTEEELANM---SLN--FLNCCCKKNGGEEENAPNPNP 5HT2C_MOUSE 5HT2C_MOUSE MLLRG-----------------HTEEELRNI---SLN--FLKCCC-KKGDEEENAPNPNP B2RUD4_MOUSE B2RUD4_MOUSE MLLRG-----------------HTEEELRNI---SLN--FLKCCC-KKGDEEENAPNPNP B1ATN5_MOUSE B1ATN5_MOUSE MLLRG-----------------HTEEELRNI---SLN--FLKCCC-KKGDEEENAPNPNP Q8BZI5_MOUSE Q8BZI5_MOUSE MLLRG-----------------HTEEELRNI---SLN--FLKCCC-KKGDEEENAPNPNP 5HT2C_CANFA 5HT2C_CANFA MLLHG------------------HVEEPPRI---NLD--FLKCCR-RNGTEEENSANPNQ Q5ISA4_9PRIM Q5ISA4_9PRIM MLLHG------------------HTEEPPGL---SLD--FLKCCK-RNTAEEENSANPNQ B3VRE4_PONPY B3VRE4_PONPY MLLHG------------------HTEEPPGL---SLD--FLKCCK-RNTAEEENSANPNQ B3VRE3_9PRIM B3VRE3_9PRIM MLLHG------------------HTEEPPGL---SLD--FLKCCK-RNTAEEENSANPNQ 5HT2C_PANTR 5HT2C_PANTR MLLHG------------------HTEEPPGL---SLD--FLKCCK-RNTAEEENSANPNQ 5HT2C_HUMAN 5HT2C_HUMAN MLLHG------------------HTEEPPGL---SLD--FLKCCK-RNTAEEENSANPNQ B3VRE0_HUMAN B3VRE0_HUMAN MLLHG------------------HTEEPPGL---SLD--FLKCCK-RNTAEEENSANPNQ B3VRE2_PANTR B3VRE2_PANTR MLLHG------------------HTEEPPGL---SLD--FLKCCK-RNTAEEENSANPNQ B3VRE1_PANPA B3VRE1_PANPA MLLHG------------------HTEEPPGL---SLD--FLKCCR-RNTAEEENSANPNQ B2WSB2_DANRE B2WSB2_DANRE VFLYEGKASSQQPLQPPAPPSSQLVPPLAPSRRSSLN--CLRISN-SDGNTLGLTVPPDT B8JHQ2_DANRE B8JHQ2_DANRE VFLYEGKASSQQPLQPPAPPSSQLVPPLAPSRRSSLN--CLR-ISNSDGNTLGLTVPPDT B3V8C3_9SAUR B3V8C3_9SAUR VFLYG------------------ETPKQRRG---SMN--CLK-----------KENNTEN B0S6G9_DANRE B0S6G9_DANRE LCLDQ------------------LVPRPKWSTGLTLN--FLP--------GPSFSPSEKK B9VWH1_9TELE B9VWH1_9TELE LCLDQ------------------LVPRPKWSTTFTLS--FLP----------QTSLSSEK B3V8C2_9SAUR B3V8C2_9SAUR LCVNG------------------LASKTSYA---SFS--FFP----------QSSLSSGK 5HT2A_BOVIN 5HT2A_BOVIN LCVSD------------------PGTRTKLA---SFS--FLP----------QSSLSSEK O97565_SHEEP O97565_SHEEP LCVSD------------------PGTRTKLA---SFS--FLP----------QSSLSSEK Q0EAB4_HORSE Q0EAB4_HORSE LCVND------------------LGTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_PIG 5HT2A_PIG LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_CANFA 5HT2A_CANFA LCVSD------------------PGTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_HUMAN 5HT2A_HUMAN LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK B4DZ79_HUMAN B4DZ79_HUMAN LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK B3VRB0_HUMAN B3VRB0_HUMAN LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK B3VRB3_9PRIM B3VRB3_9PRIM LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK Q9N2F3_9PRIM Q9N2F3_9PRIM LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK Q9P2Q9_HUMAN Q9P2Q9_HUMAN LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK B3VRB1_PANPA B3VRB1_PANPA LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK B3VRB2_PANTR B3VRB2_PANTR LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK Q9N2F4_PANTR Q9N2F4_PANTR LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK Q5ISK8_MACFA Q5ISK8_MACFA LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_MACMU 5HT2A_MACMU LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_PONPY 5HT2A_PONPY LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK B3VRB4_PONPY B3VRB4_PONPY LCVSD------------------LGTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_RAT 5HT2A_RAT LCVSD------------------LSTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_MOUSE 5HT2A_MOUSE LCVSD------------------LSTRAKLS---SFS--FLP----------QSSLSSEK Q543D4_MOUSE Q543D4_MOUSE LCVSD------------------LSTRAKLS---SFS--FLP----------QSSLSSEK 5HT2A_CAVPO 5HT2A_CAVPO LCVSD------------------PGTRAKLS---SFS--FLP----------QSSLSSEK Q4U3W9_MESAU Q4U3W9_MESAU LCVSD------------------LSTRAKLA---SFS--FLP----------QSSLSSEK 5HT2A_CRIGR 5HT2A_CRIGR LCVSD------------------LSTRAKLA---SFS--FLP----------QSSLSSEK Q9QW77_CRIGR Q9QW77_CRIGR LCVSD------------------LSTRAKLA---SFS--FLP----------QSSLSSEK MATCH : . CONSENSUS ???????????????????????????????????????F????????????????????

Q7SZL3_XENLA Q7SZL3_XENLA IAMIEGARKDG----TLSITGEELPIRRLSSVGKKSMQTITNEQRASKVLGIVFFLFVFM Q9PTB1_CHICK Q9PTB1_CHICK VAMLNGSRKDK-------TPTNDMPICRTSTIGRKSMQTITNEQRASKVLGIVFFLFLLM 5HT2B_MOUSE 5HT2B_MOUSE VAMLDGSHRDK----ILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLM 5HT2B_RAT 5HT2B_RAT MVMLDGSHKDK----ILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLM O46636_CANFA O46636_CANFA VAMLDGSHKDR----TLPSSSDDLLMRRMSTAGKKSMQTISNEQRASKVLGIVFFLFLLM Q50DZ8_CANFA Q50DZ8_CANFA VAMLDGSHKDR----TLPSSSDDLLMRRMSTAGKKSMQTISNEQRASKVLGIVFFLFLLM A3RL34_CAVPO A3RL34_CAVPO AAMLDGFHKDK----TLPNSSDETLTRQMSTIGKKSTQTISNEQRASKVLGIVFFLFLLM 5HT2B_HUMAN 5HT2B_HUMAN VAMLDGSRKDK----ALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLM B3VRC5_HUMAN B3VRC5_HUMAN VAMLDGSRKDK----ALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLM B3VRC8_9PRIM B3VRC8_9PRIM VAMLDGSRKDK----ALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLM B3VRC9_PONPY B3VRC9_PONPY VAMLDGSRKDK----ALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLM B3VRC6_PANPA B3VRC6_PANPA VAMLDGSRKDK----VLPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLM B3VRC7_PANTR B3VRC7_PANTR VAMLDGSRKDK----VLPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLM 5HT2B_TETFL 5HT2B_TETFL LARIQ-EKTDT--DGMSSPTGDEKSFRRLSTMGKKSMQTLTNEQRASKVLGIVFLLFVVM Q0GH74_DANRE Q0GH74_DANRE MVISNGIKRDRTLNPVNPITGDEVPLRRMSTIGKRSMQNLTNEQRASKVLGIVFMLFVVM Q62842_RAT Q62842_RAT DQK---PRRKK-----------------KEKRPRGTMQAINNEKKASKVLGIVFFVFLIM 5HT2C_RAT 5HT2C_RAT DQK---PRRKK-----------------KEKRPRGTMQAINNEKKASKVLGIVFFVFLIM 5HT2C_MOUSE 5HT2C_MOUSE DQK---PRRKK-----------------KEKRPRGTMQAINNEKKASKVLGIVFFVFLIM B2RUD4_MOUSE B2RUD4_MOUSE DQK---PRRKK-----------------KEKRPRGTMQAINNEKKASKVLGIVFFVFLIM B1ATN5_MOUSE B1ATN5_MOUSE DQK---PRRKK-----------------KEKRPRGTMQAINNEKKASKVLGIVFFVFLIM Q8BZI5_MOUSE Q8BZI5_MOUSE DQK---PRRKK-----------------KEKRPRGTMQAINNEKKASKVLGIVFFVFLIM 5HT2C_CANFA 5HT2C_CANFA DSNP--RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLVM Q5ISA4_9PRIM Q5ISA4_9PRIM D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM B3VRE4_PONPY B3VRE4_PONPY D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM B3VRE3_9PRIM B3VRE3_9PRIM D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM 5HT2C_PANTR 5HT2C_PANTR D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM 5HT2C_HUMAN 5HT2C_HUMAN D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM B3VRE0_HUMAN B3VRE0_HUMAN D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM B3VRE2_PANTR B3VRE2_PANTR D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM B3VRE1_PANPA B3VRE1_PANPA D-QNA-RRRKK-----------------KERRPRGTMQAINNERKASKVLGIVFFVFLIM B2WSB2_DANRE B2WSB2_DANRE ISIIP-SSEAP-----SQMNSPAGRDPAGAHGRRGMMQAIKNERRASKVLGVVFFLFLFM B8JHQ2_DANRE B8JHQ2_DANRE ISIIP-SSEAP-----SQMNSPAGRDPAGAHGRRGMMQAIKNERRASKVLGVVFFLFLFM B3V8C3_9SAUR B3V8C3_9SAUR LSMLQ-NHEAP-------SHLNSPANKEGVLFRKGTMQSINNERRASKVLGIVFFLFLIM B0S6G9_DANRE B0S6G9_DANRE LFLRRSLSREP----------GADSGVVTPPFGRHNMQSISNEQKASKVLGVVFFLFVVM B9VWH1_9TELE B9VWH1_9TELE LFRRS-ISREAGGRGSSGGLAARGSIS-GSLFGRRTMQSISNEQKASKVLGVVFFLFVVM B3V8C2_9SAUR B3V8C2_9SAUR LFQRS-LSKDL------------------ETSKRRMMQSITNEQKASKVLGIVFFLFVAM 5HT2A_BOVIN 5HT2A_BOVIN LFQRS-IHREP-----------------GSY-GRRTMQSISNEQKACKVLGIVFFLFVVM O97565_SHEEP O97565_SHEEP LFQRS-IHREP-----------------CAH-GRRTMQSISNEQKACKVLGIVFFLFVV- Q0EAB4_HORSE Q0EAB4_HORSE LFQRS-IHREP-----------------GSY-GRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_PIG 5HT2A_PIG LFQRS-IHREP-----------------GSY-GRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_CANFA 5HT2A_CANFA LFQRS-IHREP-----------------GSY-GRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_HUMAN 5HT2A_HUMAN LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM B4DZ79_HUMAN B4DZ79_HUMAN LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM B3VRB0_HUMAN B3VRB0_HUMAN LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM B3VRB3_9PRIM B3VRB3_9PRIM LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM Q9N2F3_9PRIM Q9N2F3_9PRIM LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM Q9P2Q9_HUMAN Q9P2Q9_HUMAN LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM B3VRB1_PANPA B3VRB1_PANPA LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM B3VRB2_PANTR B3VRB2_PANTR LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM Q9N2F4_PANTR Q9N2F4_PANTR LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM Q5ISK8_MACFA Q5ISK8_MACFA LFQRS-IHRDP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_MACMU 5HT2A_MACMU LFQRS-IHRDP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_PONPY 5HT2A_PONPY LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFSLFVVM B3VRB4_PONPY B3VRB4_PONPY LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_RAT 5HT2A_RAT LFQRS-IHREP-----------------GSYAGRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_MOUSE 5HT2A_MOUSE LFQRS-IHREP-----------------GSYAGRRTMQSISNEQKACKVLGIVFFLFVVM Q543D4_MOUSE Q543D4_MOUSE LFQRS-IHREP-----------------GSYAGRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_CAVPO 5HT2A_CAVPO LFQRS-IHRET-----------------GSYAGRRTMQSISNEQKACKVLGIVFFLFVVM Q4U3W9_MESAU Q4U3W9_MESAU LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM 5HT2A_CRIGR 5HT2A_CRIGR LFQRS-IHREP-----------------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVM Q9QW77_CRIGR Q9QW77_CRIGR LFQRS-IHREP-----------------GSYTGRRTMQSISNEQRACKVLGIVFFLFVVM MATCH : * :.**::*.*.**:** .*: CONSENSUS ????????????????????????????????????MQ?I?NE??A?KVLGIVFF?F??M

Q7SZL3_XENLA Q7SZL3_XENLA WCPFFLTNVASVLCGEDQCDEDVIKMLMDIFVWVGYISSGVNPLVYTLFNKTFRDAFRRY Q9PTB1_CHICK Q9PTB1_CHICK WCPFFITNISSVLCNS--CNKEVFQKLMEIFVWIGYVSSGVNPLVYTLFNKTFREAFSRY 5HT2B_MOUSE 5HT2B_MOUSE WCPFFITNLTLALCDS--CNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRY 5HT2B_RAT 5HT2B_RAT WCPFFITNVTLALCDS--CNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRY O46636_CANFA O46636_CANFA WCPFFITNVTLVLCDS--CNQTTLNMLLEVF----------------------------- Q50DZ8_CANFA Q50DZ8_CANFA WCPFFITNVTLVLCDS--CNQTTLNMLLEVFVWIGYVSSGVNPLVYTLFNKTFRNAFGRY A3RL34_CAVPO A3RL34_CAVPO WCPFFITNITLALCDS--CNQSTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY 5HT2B_HUMAN 5HT2B_HUMAN WCPFFITNITLVLCDS--CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY B3VRC5_HUMAN B3VRC5_HUMAN WCPFFITNITLVLCDS--CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY B3VRC8_9PRIM B3VRC8_9PRIM WCPFFITNITLVLCDS--CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY B3VRC9_PONPY B3VRC9_PONPY WCPFFITNITLVLCDS--CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY B3VRC6_PANPA B3VRC6_PANPA WCPFFITNITLVLCDS--CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY B3VRC7_PANTR B3VRC7_PANTR WCPFFITNITLVLCDS--CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRY 5HT2B_TETFL 5HT2B_TETFL WCPFFITNITSALCGP--CDANIIGRLMEIFSWVGYVSSGINPLVYTLFNKTFRQAFTRY Q0GH74_DANRE Q0GH74_DANRE WCPFFITNVTSVLCER--CNGNLVDQLLDIFQWVGYVSSGINPLVYTLFNRTFRLAFRRY Q62842_RAT Q62842_RAT WCPFFITNILSVLCGKA-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKY 5HT2C_RAT 5HT2C_RAT WCPFFITNILSVLCGKA-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKY 5HT2C_MOUSE 5HT2C_MOUSE WCPFFITNILSVLCGKA-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKY B2RUD4_MOUSE B2RUD4_MOUSE WCPFFITNILSVLCGKA-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKY B1ATN5_MOUSE B1ATN5_MOUSE WCPFFITNILSVLCGKA-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKY Q8BZI5_MOUSE Q8BZI5_MOUSE WCPFFITNILSVLCGKA-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKY 5HT2C_CANFA 5HT2C_CANFA WCPFFITNILSVLCGKA-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY Q5ISA4_9PRIM Q5ISA4_9PRIM WCPFFLTNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKVYRRAFSNY B3VRE4_PONPY B3VRE4_PONPY WCPFFITNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY B3VRE3_9PRIM B3VRE3_9PRIM WCPFFITNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY 5HT2C_PANTR 5HT2C_PANTR WCPFFITNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY 5HT2C_HUMAN 5HT2C_HUMAN WCPFFITNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY B3VRE0_HUMAN B3VRE0_HUMAN WCPFFITNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY B3VRE2_PANTR B3VRE2_PANTR WCPFFITNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY B3VRE1_PANPA B3VRE1_PANPA WCPFFITNILSVLCEKS-CNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY B2WSB2_DANRE B2WSB2_DANRE WCPFFVTNVLYVLCHRT-CKETLLTELLNVFVWVGYISSGVNPLVYTLFNKTYRRAFSNY B8JHQ2_DANRE B8JHQ2_DANRE WCPFFITNVLYVLCHRT-CKETLLTELLNVFVWVGYISSGVNPLVYTLFNKTYRRAFSNY B3V8C3_9SAUR B3V8C3_9SAUR WCPFFITNIMSVLCKEA-CDEELLGELLDVFVWVGYICSGVNPLVYTLFNKIYRRAFSNY B0S6G9_DANRE B0S6G9_DANRE WCPFFITNVLAVVCEPNACNANIMNRLLNVFVWVGYLSSAVNPLVYTLFNKTYRSAFARY B9VWH1_9TELE B9VWH1_9TELE WCPFFITNVLVVVCDPAVCDPVLMGGLLNVFVWVGYLSSAVNPLVYTLFNKTYRAAFLRY B3V8C2_9SAUR B3V8C2_9SAUR WCPFFITNVLAVICKEA-CNKDIIAGLLNVFVWIGYLSSAVNPLVYTMFNKTYRSAFSRY 5HT2A_BOVIN 5HT2A_BOVIN WCPFFITNIMAVICKES-CNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY O97565_SHEEP O97565_SHEEP ------------------------------------------------------------ Q0EAB4_HORSE Q0EAB4_HORSE WCPFFITNIMAVMCKES-CNEEVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_PIG 5HT2A_PIG WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_CANFA 5HT2A_CANFA WCPFFITNIMAVICKES-CNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_HUMAN 5HT2A_HUMAN WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY B4DZ79_HUMAN B4DZ79_HUMAN WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY B3VRB0_HUMAN B3VRB0_HUMAN WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY B3VRB3_9PRIM B3VRB3_9PRIM WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY Q9N2F3_9PRIM Q9N2F3_9PRIM WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY Q9P2Q9_HUMAN Q9P2Q9_HUMAN WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY B3VRB1_PANPA B3VRB1_PANPA WCPFFITNIMAVICKES-CNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY B3VRB2_PANTR B3VRB2_PANTR WCPFFITNIMAVICKES-CNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY Q9N2F4_PANTR Q9N2F4_PANTR WCPFFITNIMAVICKES-CNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY Q5ISK8_MACFA Q5ISK8_MACFA WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_MACMU 5HT2A_MACMU WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_PONPY 5HT2A_PONPY WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY B3VRB4_PONPY B3VRB4_PONPY WCPFFITNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_RAT 5HT2A_RAT WCPFFITNIMAVICKES-CNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_MOUSE 5HT2A_MOUSE WCPFFITNIMAVICKES-CNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY Q543D4_MOUSE Q543D4_MOUSE WCPFFITNIMAVICKES-CNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_CAVPO 5HT2A_CAVPO WCPFFVTNIMAVICKES-CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFA-- Q4U3W9_MESAU Q4U3W9_MESAU WCPFFITNIMAVICKES-CNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY 5HT2A_CRIGR 5HT2A_CRIGR WCPFFITNIMAVICKES-CNEHVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY Q9QW77_CRIGR Q9QW77_CRIGR WCPFFITNIMAVICKES-CNEHVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY MATCH CONSENSUS WCPFFITNI??V?C????CN??????LL??FVWIGY??S??NPLVYTLFNK??R?AF??Y

Q7SZL3_XENLA Q7SZL3_XENLA IKCDFHG-MQSVKLLRNCS-------SRISFRNSMAENSKLIMKHGMKNGINPVMYQSPL Q9PTB1_CHICK Q9PTB1_CHICK ITCNYRT-TKTSKVLRKCS-------SRISFRNSVTENSKLFVMHGMRNGINPIM----- 5HT2B_MOUSE 5HT2B_MOUSE ITCNYRA-TKSVKALRKFS-------STLCFGNSMVENSKFFTKHGIRNGINPAMYQSPM 5HT2B_RAT 5HT2B_RAT ITCNYQA-TKSVKVLRKCS-------STLYFGNSMVENSKFFTKHGIRNGINPAMYQSPV O46636_CANFA O46636_CANFA ------------------------------------------------------------ Q50DZ8_CANFA Q50DZ8_CANFA ITCNYQA-MKSVKTVRKCS-------------SNNYFRNGRELKVFHETWNVKWY----- A3RL34_CAVPO A3RL34_CAVPO ITCNYKA-TKSVKTVRKCS-------NKIYFRNPMTENSKFFMKHGMRNGINSTMYQSPV 5HT2B_HUMAN 5HT2B_HUMAN ITCNYRA-TKSVKTLRKRS-------SKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPM B3VRC5_HUMAN B3VRC5_HUMAN ITCNYRA-TKSVKTLRKRS-------SKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPM B3VRC8_9PRIM B3VRC8_9PRIM ITCNYRA-TKSVKTLRKRS-------SKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPM B3VRC9_PONPY B3VRC9_PONPY ITCNYRA-TKSVKTLRKRS-------SKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPM B3VRC6_PANPA B3VRC6_PANPA ITCNYRA-TKSVKTLRKRS-------SKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPM B3VRC7_PANTR B3VRC7_PANTR ITCNYRA-TKSVKTLRKRS-------SKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPM 5HT2B_TETFL 5HT2B_TETFL ITCNYRNFASKEQGRSFRASTVDRMLTHISPRSSVAENAKLFTKQEIKNETTD--YRSPL Q0GH74_DANRE Q0GH74_DANRE ITCNYKS-VRTPKLQRRSK---------ISFRSSVTENSKRFMKHGMKNGISPVGYQSPI Q62842_RAT Q62842_RAT LRCDYKP-DKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNERV----- 5HT2C_RAT 5HT2C_RAT LRCDYKP-DKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNERV----- 5HT2C_MOUSE 5HT2C_MOUSE LRCDYKP-DKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNERV----- B2RUD4_MOUSE B2RUD4_MOUSE LRCDYKP-DKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNERV----- B1ATN5_MOUSE B1ATN5_MOUSE LRCDYKP-DKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNERV----- Q8BZI5_MOUSE Q8BZI5_MOUSE LRCDYKP-DKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNERV----- 5HT2C_CANFA 5HT2C_CANFA LRCNYKP-EKKPPVRQMPR-------------VAATALSGRELNVNIYRHTNEPV----- Q5ISA4_9PRIM Q5ISA4_9PRIM LRCNYKI-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- B3VRE4_PONPY B3VRE4_PONPY LRCNYKV-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- B3VRE3_9PRIM B3VRE3_9PRIM LRCNYKV-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- 5HT2C_PANTR 5HT2C_PANTR LRCNYKV-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- 5HT2C_HUMAN 5HT2C_HUMAN LRCNYKV-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- B3VRE0_HUMAN B3VRE0_HUMAN LRCNYKV-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- B3VRE2_PANTR B3VRE2_PANTR LRCNYKV-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- B3VRE1_PANPA B3VRE1_PANPA LRCNYKV-EKKPPVRQIPR-------------VAATALSGRELNVNIYRHTNEPV----- B2WSB2_DANRE B2WSB2_DANRE MHCQYRHVGLKPITINVPC-------PSHAVVTPILMCDKVSIDRNSNCRNGDGNGIRNL B8JHQ2_DANRE B8JHQ2_DANRE MHCQYRHVGLKPITINVPC-------PSHAVVTPILMCDKVSIDRNSNCRNGDGNGIRNL B3V8C3_9SAUR B3V8C3_9SAUR IRCRYDS-GKKSSQRHNQG-------PN----VSSSALYGKDLNLNSYRNGNELN----- B0S6G9_DANRE B0S6G9_DANRE IRCQFHE-EKKPLQLILVN-------T-----IPPMAYQSTHLPLTG------------- B9VWH1_9TELE B9VWH1_9TELE VRCRYQP-EKKPLQLILVN-------T-----IPPLAYNSSQL---IRNGA--------- B3V8C2_9SAUR B3V8C2_9SAUR IQCRYKE-EKKPLQLFLEN-------T-----IPAIAYNSSQLQIAFKRES--------- 5HT2A_BOVIN 5HT2A_BOVIN IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGPKKNSKKDD----- O97565_SHEEP O97565_SHEEP ------------------------------------------------------------ Q0EAB4_HORSE Q0EAB4_HORSE IQCQYKE-NKKPLQLILVN-------T-----IPTLAYKSSQLQMGQNKNSKKDA----- 5HT2A_PIG 5HT2A_PIG IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQTGQKENSKQDD----- 5HT2A_CANFA 5HT2A_CANFA IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKKDA----- 5HT2A_HUMAN 5HT2A_HUMAN IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- B4DZ79_HUMAN B4DZ79_HUMAN IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- B3VRB0_HUMAN B3VRB0_HUMAN IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- B3VRB3_9PRIM B3VRB3_9PRIM IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- Q9N2F3_9PRIM Q9N2F3_9PRIM IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- Q9P2Q9_HUMAN Q9P2Q9_HUMAN IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- B3VRB1_PANPA B3VRB1_PANPA IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- B3VRB2_PANTR B3VRB2_PANTR IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- Q9N2F4_PANTR Q9N2F4_PANTR IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- Q5ISK8_MACFA Q5ISK8_MACFA IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- 5HT2A_MACMU 5HT2A_MACMU IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- 5HT2A_PONPY 5HT2A_PONPY IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- B3VRB4_PONPY B3VRB4_PONPY IQCQYKE-NKKPLQLILVN-------T-----IPALAYKSSQLQMGQKKNSKQDA----- 5HT2A_RAT 5HT2A_RAT IQCQYKE-NRKPLQLILVN-------T-----IPALAYKSSQLQVGQKKNSQEDA----- 5HT2A_MOUSE 5HT2A_MOUSE IQCQYKE-NRKPLQLILVN-------T-----IPTLAYKSSQLQVGQKKNSQEDA----- Q543D4_MOUSE Q543D4_MOUSE IQCQYKE-NRKPLQLILVN-------T-----IPTLAYKSSQLQVGQKKNSQEDA----- 5HT2A_CAVPO 5HT2A_CAVPO ------------------------------------------------------------ Q4U3W9_MESAU Q4U3W9_MESAU IQCQYKE-NRKPLQLILVN-------T-----IPALAYKSGQLQAGQNKNSKEDS----- 5HT2A_CRIGR 5HT2A_CRIGR IQCQYKE-NRKPLQLILVN-------T-----IPALAYKSSQLQAGQNKDSKEDA----- Q9QW77_CRIGR Q9QW77_CRIGR IQCQYKE-NRKPLQLILVN-------T-----IPALAYKSSQLQAGQNKDSKEDA----- MATCH CONSENSUS ??C?Y???????????????????????????????????????????????????????

Q7SZL3_XENLA Q7SZL3_XENLA RLCNAQLESSAIL-LDTLLLTENEAGKTEEQASYV Q9PTB1_CHICK Q9PTB1_CHICK ----------------------------------- 5HT2B_MOUSE 5HT2B_MOUSE RLRSSTIQSSSIILLDTL-LTENDGDKAEEQVSYI 5HT2B_RAT 5HT2B_RAT RLRSSTIQSSSIILLNTF-LTENDGDKVEDQVSYI O46636_CANFA O46636_CANFA ----------------------------------- Q50DZ8_CANFA Q50DZ8_CANFA ----------------------------------- A3RL34_CAVPO A3RL34_CAVPO RLRNSTTQSSSIILLDTPLLTENEGDKTEEQVSYV 5HT2B_HUMAN 5HT2B_HUMAN RLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV B3VRC5_HUMAN B3VRC5_HUMAN RLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV B3VRC8_9PRIM B3VRC8_9PRIM RLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV B3VRC9_PONPY B3VRC9_PONPY RLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV B3VRC6_PANPA B3VRC6_PANPA RLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV B3VRC7_PANTR B3VRC7_PANTR RLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV 5HT2B_TETFL 5HT2B_TETFL GCLQPSAQTSTGVVLDKILLTHTENCKQEERVSCV Q0GH74_DANRE Q0GH74_DANRE RHRSTQLQTSANIMLDTLLLTDNEDCKPDEHVSHV Q62842_RAT Q62842_RAT ARKANDPEPGIEMQVENLELPVNPSNVVSERISSV 5HT2C_RAT 5HT2C_RAT ARKANDPEPGIEMQVENLELPVNPSNVVSERISSV 5HT2C_MOUSE 5HT2C_MOUSE VRKANDTEPGIEMQVENLELPVNPSNVVSERISSV B2RUD4_MOUSE B2RUD4_MOUSE VRKANDTEPGIEMQVENLELPVNPSNVVSERISSV B1ATN5_MOUSE B1ATN5_MOUSE VRKANDTEPGIEMQVENLELPVNPSNVVSERISSV Q8BZI5_MOUSE Q8BZI5_MOUSE VRKANDTEPGIEMQVENLELPVNPSNVVSERISSV 5HT2C_CANFA 5HT2C_CANFA LKKANDKEPGIEMQVENLELPVNPSSVVSERISSV Q5ISA4_9PRIM Q5ISA4_9PRIM VKKTNDNEPGIEMQVENLELPVNPSSVVSER---- B3VRE4_PONPY B3VRE4_PONPY IKKASDNEPGIEMQVENLELPVNPSSVVSERISSV B3VRE3_9PRIM B3VRE3_9PRIM MEKASDNEPGIEMQVENLELPVNPSSVVSERISSV 5HT2C_PANTR 5HT2C_PANTR IEKASDNEPGIEMQVENLELPVNPSSVVSERISSV 5HT2C_HUMAN 5HT2C_HUMAN IEKASDNEPGIEMQVENLELPVNPSSVVSERISSV B3VRE0_HUMAN B3VRE0_HUMAN IEKASDNEPGIEMQVENLELPVNPSSVVSERISSV B3VRE2_PANTR B3VRE2_PANTR IEKASDNEPGIEMQVENLELPVNPSSVVSERISSV B3VRE1_PANPA B3VRE1_PANPA IEKASDNEPGIEMQVENLELPVNPSSVVSERISSV B2WSB2_DANRE B2WSB2_DANRE ETLDIDTDTGLELKPGISEISISSGHSHTEHTSSV B8JHQ2_DANRE B8JHQ2_DANRE ETLDIDTDTGLELKPGISEISISSGHSHTEHTSSV B3V8C3_9SAUR B3V8C3_9SAUR SMELDEMEDALEMHVGTSELSINSCGG--EKTSSV B0S6G9_DANRE B0S6G9_DANRE SIGNGDFSLPLPNKNHHL-----SKSGKNESVSCL B9VWH1_9TELE B9VWH1_9TELE PHSGGGAKDSPLSRQETERRQPGGIGHRGKDESCV B3V8C2_9SAUR B3V8C2_9SAUR QLIAKDYPAAKTGRHHGDRTSKSNTGQVNEKVSCL 5HT2A_BOVIN 5HT2A_BOVIN KTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV O97565_SHEEP O97565_SHEEP ----------------------------------- Q0EAB4_HORSE Q0EAB4_HORSE KMTDNDCTMVALGKQCSEDAPTDKINTVNEKVSCV 5HT2A_PIG 5HT2A_PIG KATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV 5HT2A_CANFA 5HT2A_CANFA KSTDNDYSMVALGKQHSEDAPTDNINTVNEKVSCV 5HT2A_HUMAN 5HT2A_HUMAN KTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV B4DZ79_HUMAN B4DZ79_HUMAN KTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV B3VRB0_HUMAN B3VRB0_HUMAN KTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV B3VRB3_9PRIM B3VRB3_9PRIM KTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV Q9N2F3_9PRIM Q9N2F3_9PRIM KTTDNDCSMVALGKQHSEEASKDN----------- Q9P2Q9_HUMAN Q9P2Q9_HUMAN KTTDNDCSMVALGKQHSEEASKDN----------- B3VRB1_PANPA B3VRB1_PANPA KTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV B3VRB2_PANTR B3VRB2_PANTR KTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV Q9N2F4_PANTR Q9N2F4_PANTR KTTDNDCSMVALGKQHSEEASKDN----------- Q5ISK8_MACFA Q5ISK8_MACFA KTTDNDCSMVA------------------------ 5HT2A_MACMU 5HT2A_MACMU KTTDNDCSMVALGKQHSEDASKDNSDGVNEKVSCV 5HT2A_PONPY 5HT2A_PONPY KTTDNDCSMVALGKQHSEDASKDNSDGVNEKVSCV B3VRB4_PONPY B3VRB4_PONPY KTTDNDCSMVALGKQHSEDASKDNSDGVNEKVSCV 5HT2A_RAT 5HT2A_RAT EQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV 5HT2A_MOUSE 5HT2A_MOUSE EPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV Q543D4_MOUSE Q543D4_MOUSE EPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV 5HT2A_CAVPO 5HT2A_CAVPO ----------------------------------- Q4U3W9_MESAU Q4U3W9_MESAU EPAGNDCSMVTLGKQQSDETCTDSINTMNEKVSCV 5HT2A_CRIGR 5HT2A_CRIGR EPTDNDCSMVTLGKQQSEETCTDNINTVNEKVSCV Q9QW77_CRIGR Q9QW77_CRIGR EPTDNDCSMVTLGKQQSEEYCTDNINTYNEKVSCV MATCH CONSENSUS ?????????????????????????????E??S??


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