Alignment of the gene Family HBG107814 of HOVERGEN

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Isoforms are ON
DLG4_DANRE DLG4_DANRE ------------------------------------------------------------ Q4SFK1_TETNG Q4SFK1_TETNG ------------------------------------------------------------ A4IHB8_XENTR A4IHB8_XENTR ------------------------------------------------------------ A9JRI4_XENTR A9JRI4_XENTR ------------------------------------------------------------ Q0IHR6_XENTR Q0IHR6_XENTR ------------------------------------------------------------ B7Z3U2_HUMAN B7Z3U2_HUMAN ------------------------------------------------------------ B7Z4H2_HUMAN B7Z4H2_HUMAN ------------------------------------------------------------ DLG4_MOUSE DLG4_MOUSE ------------------------------------------------------------ DLG4_RAT DLG4_RAT ------------------------------------------------------------ B7Z647_HUMAN B7Z647_HUMAN ------------------------------------------------------------ B9EGL1_HUMAN B9EGL1_HUMAN ------------------------------------------------------------ DLG4_HUMAN DLG4_HUMAN ------------------------------------------------------------ Q3ZCU5_HUMAN Q3ZCU5_HUMAN ------------------------------------------------------------ Q4SLA0_TETNG Q4SLA0_TETNG ------------------------------------------------------------ A2BGZ1_DANRE A2BGZ1_DANRE ------------------------------------------------------------ DLG2_DANRE DLG2_DANRE ------------------------------------------------------------ Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ------------------------------------------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN ------------------------------------------------------------ B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN ------------------------------------------------------------ DLG2_MOUSE DLG2_MOUSE ------------------------------------------------------------ DLG2_RAT DLG2_RAT ------------------------------------------------------------ B7Z395_HUMAN B7Z395_HUMAN ------------------------------------------------------------ A8MVF1_HUMAN A8MVF1_HUMAN ------------------------------------------------------------ DLG2_HUMAN DLG2_HUMAN ------------------------------------------------------------ Q4RP82_TETNG Q4RP82_TETNG ------------------------------------------------------------ A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN ------------------------------------------------------------ DLG3_HUMAN DLG3_HUMAN ------------------------------------------------------------ Q59FY1_HUMAN Q59FY1_HUMAN --------------APASSLPLGLGPEATTGDTEPPVLEGEPWVRGSVGAEAPGRPPGPR DLG3_RAT DLG3_RAT ------------------------------------------------------------ Q80TH1_MOUSE Q80TH1_MOUSE HSDPSWGPEQKRFSPHLAFAWAPDSSLPLGLGPEATTGDTEPPVLEGEPWVRGSVGAEAP Q52KF7_MOUSE Q52KF7_MOUSE ------------------------------------------------------------ A2BEF1_MOUSE A2BEF1_MOUSE ------------------------------------------------------------ DLG3_MOUSE DLG3_MOUSE ------------------------------------------------------------ A2BEE9_MOUSE A2BEE9_MOUSE ------------------------------------------------------------ A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE ------------------------------------------------------------ A2BHX2_DANRE A2BHX2_DANRE ------------------------------------------------------------ DLG1L_DANRE DLG1L_DANRE ------------------------------------------------------------ DLG1_RAT DLG1_RAT ------------------------------------------------------------ Q571K0_MOUSE Q571K0_MOUSE ------------------------------------------------------------ B9EIQ5_HUMAN B9EIQ5_HUMAN ------------------------------------------------------------ B4DF78_HUMAN B4DF78_HUMAN ------------------------------------------------------------ B4DGZ8_HUMAN B4DGZ8_HUMAN ------------------------------------------------------------ DLG1_HUMAN DLG1_HUMAN ------------------------------------------------------------ B4DGU1_HUMAN B4DGU1_HUMAN ------------------------------------------------------------ Q59FC4_HUMAN Q59FC4_HUMAN ------------------------------------------------------------ Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE ------------------------------------------------------------ Q3UP61_MOUSE Q3UP61_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE ------------MPLKREDTERALQAMEACQS----AGDEGFRTRAERLLTIFQSDLFQA Q4SFK1_TETNG Q4SFK1_TETNG ------------------------------------------------------------ A4IHB8_XENTR A4IHB8_XENTR ------------------------------------------------------------ A9JRI4_XENTR A9JRI4_XENTR ------------------------------------------------------------ Q0IHR6_XENTR Q0IHR6_XENTR ------------------------------------------------------------ B7Z3U2_HUMAN B7Z3U2_HUMAN ------------------------------------------------------------ B7Z4H2_HUMAN B7Z4H2_HUMAN ------------------------------------------------------------ DLG4_MOUSE DLG4_MOUSE ------------------------------------------------------------ DLG4_RAT DLG4_RAT ------------------------------------------------------------ B7Z647_HUMAN B7Z647_HUMAN ------------------------------------------------------------ B9EGL1_HUMAN B9EGL1_HUMAN ------------------------------------------------------------ DLG4_HUMAN DLG4_HUMAN ------------------------------------------------------------ Q3ZCU5_HUMAN Q3ZCU5_HUMAN ------------------------------------------------------------ Q4SLA0_TETNG Q4SLA0_TETNG ------------------------------------------------------------ A2BGZ1_DANRE A2BGZ1_DANRE ------------------------------------------------------------ DLG2_DANRE DLG2_DANRE ---------------------------------------------------------MKA Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ------------------------------------------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN ------------------------------------------------------------ B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN ------------------------------------------------------------ DLG2_MOUSE DLG2_MOUSE ------------------------------------------------------------ DLG2_RAT DLG2_RAT ------------------------------------------------------------ B7Z395_HUMAN B7Z395_HUMAN ------------------------------------------------------------ A8MVF1_HUMAN A8MVF1_HUMAN ------------------------------------------------------------ DLG2_HUMAN DLG2_HUMAN ------------------------------------------------------------ Q4RP82_TETNG Q4RP82_TETNG ------------------------------------------------------------ A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN ------------------------------------------------------MHKHQH DLG3_HUMAN DLG3_HUMAN ------------------------------------------------------MHKHQH Q59FY1_HUMAN Q59FY1_HUMAN PRSARAPPRVPPPSWSEQCECAREPGGGGGGGGGGGGGVESGVGWGVRAAGGSAMHKHQH DLG3_RAT DLG3_RAT ------------------------------------------------------MHKHQH Q80TH1_MOUSE Q80TH1_MOUSE GRPPGPRPRSARAPPRVPPPSWSEQCECAREPGGGGGGVETGVGWGVRAAGGSAMHKHQH Q52KF7_MOUSE Q52KF7_MOUSE ------------------------------------------------------MHKHQH A2BEF1_MOUSE A2BEF1_MOUSE ------------------------------------------------------MHKHQH DLG3_MOUSE DLG3_MOUSE ------------------------------------------------------MHKHQH A2BEE9_MOUSE A2BEE9_MOUSE ------------------------------------------------------MHKHQH A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE ------------MPVRQKDAQRALQLLEEYQTKLSQTGDPHLRLSIERVINIFKSTLFQA A2BHX2_DANRE A2BHX2_DANRE ------------------------------------------------------------ DLG1L_DANRE DLG1L_DANRE ------------------------------------------------------------ DLG1_RAT DLG1_RAT ------------MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVISIFQSNLFQA Q571K0_MOUSE Q571K0_MOUSE --------FWRKMPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQA B9EIQ5_HUMAN B9EIQ5_HUMAN ------------MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQA B4DF78_HUMAN B4DF78_HUMAN ------------------------------------------------------------ B4DGZ8_HUMAN B4DGZ8_HUMAN ------------------------------------------------------------ DLG1_HUMAN DLG1_HUMAN ------------MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQA B4DGU1_HUMAN B4DGU1_HUMAN ------------------------------------------------------------ Q59FC4_HUMAN Q59FC4_HUMAN ------------------------------------------------------------ Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE ------------MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQA Q3UP61_MOUSE Q3UP61_MOUSE ------------MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQA MATCH CONSENSUS ????????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE LLDIQEFYELTVF-----------------------------------------ENQTAG Q4SFK1_TETNG Q4SFK1_TETNG ------------------------------------------------------------ A4IHB8_XENTR A4IHB8_XENTR ---------------------------REPGGRAPGRDGASSS-----SSGTASTGAMDC A9JRI4_XENTR A9JRI4_XENTR ---------------------AAEQGQREPGGRAPGRDGASSS-----SSGTASTGAMDC Q0IHR6_XENTR Q0IHR6_XENTR -----------------------------PGGRAPGRDGASSS-----SSGTASTGAMDC B7Z3U2_HUMAN B7Z3U2_HUMAN --------------MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYE B7Z4H2_HUMAN B7Z4H2_HUMAN ------------------------------------------------------------ DLG4_MOUSE DLG4_MOUSE ---------------------------------------------------------MDC DLG4_RAT DLG4_RAT ---------------------------------------------------------MDC B7Z647_HUMAN B7Z647_HUMAN ------------------------------------------------------------ B9EGL1_HUMAN B9EGL1_HUMAN --------------MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYE DLG4_HUMAN DLG4_HUMAN ---------------------------------------------------------MDC Q3ZCU5_HUMAN Q3ZCU5_HUMAN ------------------------------------------------------------ Q4SLA0_TETNG Q4SLA0_TETNG ------------------MSFWGKQQWDRMISTSSLTDSLHGG----SVPNLQSPPRSES A2BGZ1_DANRE A2BGZ1_DANRE ---------------QNRPPAVQGSQHQSHSPACMNPALMSSPWVRQKHGGRAIPNRLCL DLG2_DANRE DLG2_DANRE VVRVLKLEERAVHRQQNRPPAVQGSQHQSHSPACMNPALMSSPWVRQKHGGRAIPNRLCL Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ------------------------------------------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN -------------------------------------------------------MFFAC B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN ------------------------------------------------------------ DLG2_MOUSE DLG2_MOUSE -------------------------------------------------------MFFAC DLG2_RAT DLG2_RAT -------------------------------------------------------MFFAC B7Z395_HUMAN B7Z395_HUMAN ------------------------------------------------------------ A8MVF1_HUMAN A8MVF1_HUMAN ------------------------------------------------------------ DLG2_HUMAN DLG2_HUMAN -------------------------------------------------------MFFAC Q4RP82_TETNG Q4RP82_TETNG ------------------------------------------------------------ A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASA----GYGGYSSQTLPSQ DLG3_HUMAN DLG3_HUMAN CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASA----GYGGYSSQTLPSQ Q59FY1_HUMAN Q59FY1_HUMAN CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASA----GYGGYSSQTLPSQ DLG3_RAT DLG3_RAT CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASS----GYGGYSSQTLPSQ Q80TH1_MOUSE Q80TH1_MOUSE CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASS----GYGGYSSQTLPSQ Q52KF7_MOUSE Q52KF7_MOUSE CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASS----GYGGYSSQTLPSQ A2BEF1_MOUSE A2BEF1_MOUSE CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASS----GYGGYSSQTLPSQ DLG3_MOUSE DLG3_MOUSE CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASS----GYGGYSSQTLPSQ A2BEE9_MOUSE A2BEE9_MOUSE CCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASS----GYGGYSSQTLPSQ A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE LVDIQEYYEVSLQDTEDKPIEDSSLKSRESFPPVNEWNLSVPP-----STTGPTEPVPIN A2BHX2_DANRE A2BHX2_DANRE ---------------------------MSPSIKKLDCFSPMLCHCKVACTNSTISLMFGC DLG1L_DANRE DLG1L_DANRE ---------------------------MSPSIKKLDCFSPMLCHCKVACTNSTISLMFGC DLG1_RAT DLG1_RAT LIDIQEFYEVTLL---DNPKCVDHSKQCEPVQPGNPWESGSLS-----SAAVTSESLPGG Q571K0_MOUSE Q571K0_MOUSE LIDIQEFYEVTLL---DNPKCVDHSKQCEPVQPVTTWEIASLP-----STAVTSETLPGS B9EIQ5_HUMAN B9EIQ5_HUMAN LIDIQEFYEVTLL---DNPKCIDRSKPSEPIQPVNTWEISSLP-----SSTVTSETLPSS B4DF78_HUMAN B4DF78_HUMAN ------------------------------------------------------------ B4DGZ8_HUMAN B4DGZ8_HUMAN -------------------MNYIFGNNTLLYSRGSRGGNTSSS--------------HGS DLG1_HUMAN DLG1_HUMAN LIDIQEFYEVTLL---DNPKCIDRSKPSEPIQPVNTWEISSLP-----SSTVTSETLPSS B4DGU1_HUMAN B4DGU1_HUMAN -------------------MNYIFGNNTLLYSRGSRGGNTSSS--------------HGS Q59FC4_HUMAN Q59FC4_HUMAN ------------------------------------------------------------ Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE LIDIQEFYEVTLL---DNPKCVDHSKQCEPVQPVTTWEIASLP-----STAVTSETLPGS Q3UP61_MOUSE Q3UP61_MOUSE LIDIQEFYEVTLL---DNPKCVDHSKQCEPVQPVTTWEIASLP-----STAVTSETLPGS MATCH CONSENSUS ????????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE RALTPGLKYRYHDEE-TPPLQHSPAHLSTGKSA-EMLHLGD--SGHAPIDGIHAYTPQMH Q4SFK1_TETNG Q4SFK1_TETNG ------QKYRYQDEE-TPPLEHSPAHLAPGKSA-EMLHMSD--KNLAAMEAIHGYTPHTH A4IHB8_XENTR A4IHB8_XENTR LCIVTTKKYRYQDDD-SPPLEHSPAHLANPMKAPELVHVSE--KNLSQIESVHGYVSHSH A9JRI4_XENTR A9JRI4_XENTR LCIVTTKKYRYQDDD-SPPLEHSPAHLANPMKAPELVHVSE--KNLSQIESVHGYVSHSH Q0IHR6_XENTR Q0IHR6_XENTR LCIVTTKKYRYQDDD-SPPLEHSPAHLANPMKAPELVHVSE--KNLSQIESVHGYVSHSH B7Z3U2_HUMAN B7Z3U2_HUMAN ASLSESQKYRYQDED-TPPLEHSPAHLPNQ------------------------------ B7Z4H2_HUMAN B7Z4H2_HUMAN ------------------------------------------------------------ DLG4_MOUSE DLG4_MOUSE LCIVTTKKYRYQDED-TPPLEHSPAHLPNQ------------------------------ DLG4_RAT DLG4_RAT LCIVTTKKYRYQDED-TPPLEHSPAHLPNQ------------------------------ B7Z647_HUMAN B7Z647_HUMAN ------------------------------------------------------------ B9EGL1_HUMAN B9EGL1_HUMAN ASLSESQKYRYQDED-TPPLEHSPAHLPNQ------------------------------ DLG4_HUMAN DLG4_HUMAN LCIVTTKKYRYQDED-TPPLEHSPAHLPNQ------------------------------ Q3ZCU5_HUMAN Q3ZCU5_HUMAN ------------------------------------------------------------ Q4SLA0_TETNG Q4SLA0_TETNG SGTLKTRVSVDFLRDWASDLGSLSAGLNLSLSSAKWPSLVTVCKWKQSLTEKLKKRPSSS A2BGZ1_DANRE A2BGZ1_DANRE STTDSPHSYRYQDDD-SPPPEHSFPRLTNEVRAPELVHVSE--KNLSEIENVHGYVSHSH DLG2_DANRE DLG2_DANRE STTDSPHSYRYQDDD-SPPPEHSFPRLTNEVRAPELVHVSE--KNLSEIENVHGYVSHSH Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ------------------------------------------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN YCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSE--KNLSQIENVHGYVLQSH B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN --------------------------------------------------MQHAFIP--- DLG2_MOUSE DLG2_MOUSE YCALRTNVKKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSE--KNLSQIENVHGYVLQSH DLG2_RAT DLG2_RAT YCALRTNVKKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSE--KNLSQIENVHGYVLQSH B7Z395_HUMAN B7Z395_HUMAN --------------------MQRPSVSRAENYQLLWDTIAS--LKQCEQAMQHAFIP--- A8MVF1_HUMAN A8MVF1_HUMAN ------------------------------------------------------------ DLG2_HUMAN DLG2_HUMAN YCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSE--KNLSQIENVHGYVLQSH Q4RP82_TETNG Q4RP82_TETNG -MVDNHVSHNYMGAM-EPKPVYPPPQVTPSRYSPVPRHM--------------------- A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQ--- DLG3_HUMAN DLG3_HUMAN AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQ--- Q59FY1_HUMAN Q59FY1_HUMAN AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQ--- DLG3_RAT DLG3_RAT AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKNTPKLNGSGPSWWPECTCTNRDWYEQ--- Q80TH1_MOUSE Q80TH1_MOUSE AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQ--- Q52KF7_MOUSE Q52KF7_MOUSE AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQ--- A2BEF1_MOUSE A2BEF1_MOUSE AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQ--- DLG3_MOUSE DLG3_MOUSE AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQ--- A2BEE9_MOUSE A2BEE9_MOUSE AGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPGWWPECTCTNRDWYEQ--- A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE L-PQTEEKYRYQDEDTTSPPEHSSPHIPGDARPPELVQVSE--KNISQIENVHGYVSHSH A2BHX2_DANRE A2BHX2_DANRE ------KKYRHQDEDTGSPQEPSSPQFTDDTPGPELVQVAE--KSLSQIENVHGFVAHSH DLG1L_DANRE DLG1L_DANRE ------KKYRHQDEDTGSPQEPSSPQFTDDTPGPELVQVAE--KSLSQIENVHGFVAHSH DLG1_RAT DLG1_RAT LSP-PVEKYRYQDEE-VLPSERISPQVPNEVLGPELVHVSE--KSLSEIENVHGFVSHSH Q571K0_MOUSE Q571K0_MOUSE LSP-PVEKYRYQDEE-VLPPEHISPQVTNEVLGPELVHVSE--KNLSEIENVHGFVSHSH B9EIQ5_HUMAN B9EIQ5_HUMAN LSP-SVEKYRYQDED-TPPQEHISPQITNEVIGPELVHVSE--KNLSEIENVHGFVSHSH B4DF78_HUMAN B4DF78_HUMAN ------------------------------------------------------------ B4DGZ8_HUMAN B4DGZ8_HUMAN AGPKQKHWAKKGSSD-ELQAEPEPSRWQ---------------QIVAFFTRRHSFIDCIS DLG1_HUMAN DLG1_HUMAN LSP-SVEKYRYQDED-TPPQEHISPQITNEVIGPELVHVSE--KNLSEIENVHGFVSHSH B4DGU1_HUMAN B4DGU1_HUMAN AGPKQKHWAKKGSSD-ELQAEPEPSRWQ---------------QIVAFFTRRHSFIDCIS Q59FC4_HUMAN Q59FC4_HUMAN ------------------------------------------------------------ Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE LSP-PVEKYRYQDEE-VLPPEHISPQVTNEVLGPELVHVSE--KNLSEIENVHGFVSHSH Q3UP61_MOUSE Q3UP61_MOUSE LGP-PVEKYRYQDEE-VLPPEHISPQVTNEVLGPELVHVSE--KNLSEIENVHGFVSHSH MATCH CONSENSUS ????????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE VSPAK-------------------------------------------PVLLPSGHAPYY Q4SFK1_TETNG Q4SFK1_TETNG ISPVK---------------------------------------GNTPPVVVNTDTLDGS A4IHB8_XENTR A4IHB8_XENTR ISPMK---------------------------------------ASSPPVIVNTDTLEAP A9JRI4_XENTR A9JRI4_XENTR ISPMK---------------------------------------ASSPPVIVNTDTLEAP Q0IHR6_XENTR Q0IHR6_XENTR ISPMK---------------------------------------ASSPPVIVNTDTLEAP B7Z3U2_HUMAN B7Z3U2_HUMAN --------------------------------------------ANSPPVIVNTDTLEAP B7Z4H2_HUMAN B7Z4H2_HUMAN ------------------------------------------------------------ DLG4_MOUSE DLG4_MOUSE --------------------------------------------ANSPPVIVNTDTLEAP DLG4_RAT DLG4_RAT --------------------------------------------ANSPPVIVNTDTLEAP B7Z647_HUMAN B7Z647_HUMAN ------------------------------------------------------------ B9EGL1_HUMAN B9EGL1_HUMAN --------------------------------------------ANSPPVIVNTDTLEAP DLG4_HUMAN DLG4_HUMAN --------------------------------------------ANSPPVIVNTDTLEAP Q3ZCU5_HUMAN Q3ZCU5_HUMAN ------------------------------------------------------------ Q4SLA0_TETNG Q4SLA0_TETNG TDESQ---------------------------------------ASPAPIIVNTDTLDSV A2BGZ1_DANRE A2BGZ1_DANRE ISPLK---------------------------------------ASPAPIIVNTDTLESV DLG2_DANRE DLG2_DANRE ISPLK---------------------------------------ASPAPIIVNTDTLESV Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ------------------------------------------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN ISPLK---------------------------------------ASPAPIIVNTDTLDTI B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN --------------------------------------------ASPAPIIVNTDTLDTI DLG2_MOUSE DLG2_MOUSE ISPLK---------------------------------------ASPAPIIVNTDTLDTI DLG2_RAT DLG2_RAT ISPLK---------------------------------------ASPAPIIVNTDTLDTI B7Z395_HUMAN B7Z395_HUMAN --------------------------------------------ASPAPIIVNTDTLDTI A8MVF1_HUMAN A8MVF1_HUMAN ----Q---------------------------------------ASPAPIIVNTDTLDTI DLG2_HUMAN DLG2_HUMAN ISPLK---------------------------------------ASPAPIIVNTDTLDTI Q4RP82_TETNG Q4RP82_TETNG ------------------------------------------------------------ A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN --------------------------------------------ARPAPLLVNPETLKHS DLG3_HUMAN DLG3_HUMAN ------------------------------------------------------------ Q59FY1_HUMAN Q59FY1_HUMAN ------------------------------------------------------------ DLG3_RAT DLG3_RAT --------------------------------------------ASPAPLLVNPEALEPS Q80TH1_MOUSE Q80TH1_MOUSE --------------------------------------------ASPAPLLVNPEALEPS Q52KF7_MOUSE Q52KF7_MOUSE ------------------------------------------------------------ A2BEF1_MOUSE A2BEF1_MOUSE --------------------------------------------ASPAPLLVNPEALEPS DLG3_MOUSE DLG3_MOUSE --------------------------------------------ASPAPLLVNPEALEPS A2BEE9_MOUSE A2BEE9_MOUSE --------------------------------------------ASPAPLLVNPEALEPS A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE ISPMKQADVIPPPSAPIIPVIPISPVPAETTAIIPAPASQ----ASPAPVVVNTESLDSS A2BHX2_DANRE A2BHX2_DANRE ISPMKVESLECIFDGPSPVVKEESPPSPSTPLSNPYPQSPVSVQANPPPVVVNTESLDSA DLG1L_DANRE DLG1L_DANRE ISPMKVESLECIFDGPSPVVKEESPPSPSTPLSNPYPQSPVSVQANPPPVVVNTESLDSA DLG1_RAT DLG1_RAT ISPIKPTEAVPPSSPIVPVTPALPVPAESPVVLPSTPQ------ANPPPVLVNTDSLETP Q571K0_MOUSE Q571K0_MOUSE ISPIK---------------------------------------ANPPPVLVNTDSLETP B9EIQ5_HUMAN B9EIQ5_HUMAN ISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQ------ANPPPVLVNTDSLETP B4DF78_HUMAN B4DF78_HUMAN ------------------------------------------------------------ B4DGZ8_HUMAN B4DGZ8_HUMAN VATSSTQ-------------------------------------ANPPPVLVNTDSLETP DLG1_HUMAN DLG1_HUMAN ISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQ------ANPPPVLVNTDSLETP B4DGU1_HUMAN B4DGU1_HUMAN VATSSTQ-------------------------------------ANPPPVLVNTDSLETP Q59FC4_HUMAN Q59FC4_HUMAN ------------------------------------------------------------ Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE ISPIKPTEAVPPSSPIVPVTPALPVPAESTVVLPSAPQ------ANPPPVLVNTDSLETP Q3UP61_MOUSE Q3UP61_MOUSE ISPIK---------------------------------------ANPPPVLVNTDSLETP MATCH CONSENSUS ????????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE ATSTLMNGMDGDVEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD Q4SFK1_TETNG Q4SFK1_TETNG PY---VNGTEGEIEYEEITLERGNSGLGFSIAGGTDNPHVGDDPSIFITKIIPGGAAAQD A4IHB8_XENTR A4IHB8_XENTR AY---VNGTEAEMEYEEITLERGNSGLGFSIAGGTDNPHVGDDPSIFITKIIPGGAAAQD A9JRI4_XENTR A9JRI4_XENTR AY---VNGTEAEMEYEEITLERGNSGLGFSIAGGTDNPHVGDDPSIFITKIIPGGAAAQD Q0IHR6_XENTR Q0IHR6_XENTR AY---VNGTEAEMEYEEITLERGNSGLGFSIAGGTDNPHVGDDPSIFITKIIPGGAAAQD B7Z3U2_HUMAN B7Z3U2_HUMAN GYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD B7Z4H2_HUMAN B7Z4H2_HUMAN ------------MEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD DLG4_MOUSE DLG4_MOUSE GYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD DLG4_RAT DLG4_RAT GYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD B7Z647_HUMAN B7Z647_HUMAN ------------MEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD B9EGL1_HUMAN B9EGL1_HUMAN GY---VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD DLG4_HUMAN DLG4_HUMAN GYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD Q3ZCU5_HUMAN Q3ZCU5_HUMAN ------------------------------------------------------------ Q4SLA0_TETNG Q4SLA0_TETNG PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGKETQRQKPTV--------- A2BGZ1_DANRE A2BGZ1_DANRE PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED DLG2_DANRE DLG2_DANRE PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ------------------------------------------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED DLG2_MOUSE DLG2_MOUSE PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGGDPGIFITKIIPGGAAAED DLG2_RAT DLG2_RAT PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED B7Z395_HUMAN B7Z395_HUMAN PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED A8MVF1_HUMAN A8MVF1_HUMAN PY---VSGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED DLG2_HUMAN DLG2_HUMAN PY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED Q4RP82_TETNG Q4RP82_TETNG -----LGEEDFTSRAEPIT----------ALDPGQNGPLI---PTIQI------------ A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN LS---VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD DLG3_HUMAN DLG3_HUMAN -----VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD Q59FY1_HUMAN Q59FY1_HUMAN -----VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD DLG3_RAT DLG3_RAT LS---VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD Q80TH1_MOUSE Q80TH1_MOUSE LS---VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD Q52KF7_MOUSE Q52KF7_MOUSE -----VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD A2BEF1_MOUSE A2BEF1_MOUSE LS---VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD DLG3_MOUSE DLG3_MOUSE LS---VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD A2BEE9_MOUSE A2BEE9_MOUSE LS---VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD A2BEF2_MOUSE A2BEF2_MOUSE --------METARKFSGSSLA-----LGLGSASASAWRRASQRWAWPLRSLRPGGDA--- B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN --------MERARKFSGSGLA-----MGLGSASASAWRRASQRWAWPLRSLRPGGDAR-- Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG --------------------------------------DTSDD----------------- DLG1_DANRE DLG1_DANRE PY---VNGTEADYEYEEITLERGNSGLGFSIAGGTDNPHIGEDPSIFITKIIPGGAAAQD A2BHX2_DANRE A2BHX2_DANRE PY---VNGTEADFEYEEITLERGNSGLGFSIAGGTDNPHIGEDPSIFITKVIPGGAAAQD DLG1L_DANRE DLG1L_DANRE PY---VNGTEADFEYEEITLERGNSGLGFSIAGGTDNPHIGEDPSIFITKVIPGGAAAQD DLG1_RAT DLG1_RAT TY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD Q571K0_MOUSE Q571K0_MOUSE TY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD B9EIQ5_HUMAN B9EIQ5_HUMAN TY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD B4DF78_HUMAN B4DF78_HUMAN ------------------------------------------------------------ B4DGZ8_HUMAN B4DGZ8_HUMAN TY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD DLG1_HUMAN DLG1_HUMAN TY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD B4DGU1_HUMAN B4DGU1_HUMAN TY---VNGTDADYEYEEITLERGNSGLGFNIAGGTDNPHIGDDSSIFITKIITGGAAAQD Q59FC4_HUMAN Q59FC4_HUMAN ----------------------GNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE TY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD Q3UP61_MOUSE Q3UP61_MOUSE TY---VNGTDADYGYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQD MATCH CONSENSUS ????????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE GRLRVNDSILFVNDVDVREVTHSFAVEALKEAGPIVRLYVLRHKPSAEKITELKLIKGPK Q4SFK1_TETNG Q4SFK1_TETNG GRLSVNDCILFVNDVDVREVTHSQAVEALKEAGAIVRLYVLRRKPAAEKVTEIKLIKGPK A4IHB8_XENTR A4IHB8_XENTR GRLRVNDSILFVNDVDVREVTHSTAVEALKDAGSIVRLYVMRRKPASEKIIEIKLIKGPK A9JRI4_XENTR A9JRI4_XENTR GRLRVNDSILFVNDVDVREVTHSTAVEALKDAGSIVRLYVMRRKPASEKIIEIKLIKGPK Q0IHR6_XENTR Q0IHR6_XENTR GRLRVNDSILFVNDVDVREVTHSTAVEALKDAGSIVRLYVMRRKPASEKIIEIKLIKGPK B7Z3U2_HUMAN B7Z3U2_HUMAN GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPK B7Z4H2_HUMAN B7Z4H2_HUMAN GRLRVNDSILFVNEVDVREVTHSVAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPK DLG4_MOUSE DLG4_MOUSE GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKIIEIKLIKGPK DLG4_RAT DLG4_RAT GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPK B7Z647_HUMAN B7Z647_HUMAN GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPK B9EGL1_HUMAN B9EGL1_HUMAN GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPK DLG4_HUMAN DLG4_HUMAN GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPK Q3ZCU5_HUMAN Q3ZCU5_HUMAN ------------------------------------------------------------ Q4SLA0_TETNG Q4SLA0_TETNG GTPRVNDCILRVNDTDVSEVSHSKAVEALKVAGSIVRLYVRRRRPMIETIIEIKLIKGPK A2BGZ1_DANRE A2BGZ1_DANRE GRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYVRRRRPMLETVTEIKLIKGPK DLG2_DANRE DLG2_DANRE GRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYVRRRRPMLETVTEIKLIKGPK Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ------------------------------------------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK DLG2_MOUSE DLG2_MOUSE GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK DLG2_RAT DLG2_RAT GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK B7Z395_HUMAN B7Z395_HUMAN GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK A8MVF1_HUMAN A8MVF1_HUMAN GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK DLG2_HUMAN DLG2_HUMAN GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK Q4RP82_TETNG Q4RP82_TETNG ---------------------------------SVPRENLRRSAGEMDKNVQ-------- A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK DLG3_HUMAN DLG3_HUMAN GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK Q59FY1_HUMAN Q59FY1_HUMAN GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK DLG3_RAT DLG3_RAT GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK Q80TH1_MOUSE Q80TH1_MOUSE GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK Q52KF7_MOUSE Q52KF7_MOUSE GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK A2BEF1_MOUSE A2BEF1_MOUSE GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK DLG3_MOUSE DLG3_MOUSE GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK A2BEE9_MOUSE A2BEE9_MOUSE GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE GRLRVNDCILRVNDVDVRDVTHSNAVEALKEAGCIVRLYVRRRKPLSEKIMDVKLVKGPK A2BHX2_DANRE A2BHX2_DANRE GRLRVNDVILRVNEVDVRDVTHSKAVEALKEAGSLVRLYVRRRKSASEKVMEIKLIKGPK DLG1L_DANRE DLG1L_DANRE GRLRVNDVILRVNEVDVRDVTHSKAVEALKEAGSLVRLYVRRRKSASEKVMEIKLIKGPK DLG1_RAT DLG1_RAT GRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRK-AFRKNHEIKLIKGPK Q571K0_MOUSE Q571K0_MOUSE GRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKLIKGPK B9EIQ5_HUMAN B9EIQ5_HUMAN GRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPK B4DF78_HUMAN B4DF78_HUMAN --------------------------------------------------MEIKLIKGPK B4DGZ8_HUMAN B4DGZ8_HUMAN GRLRVNDCILQVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPK DLG1_HUMAN DLG1_HUMAN GRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPK B4DGU1_HUMAN B4DGU1_HUMAN GRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPK Q59FC4_HUMAN Q59FC4_HUMAN GRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPK Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE -----------------------KAVEALKEAGSIVRLYVKRRKPASEKIMEIKLIKGPK DLG1_MOUSE DLG1_MOUSE GRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKLIKGPK Q3UP61_MOUSE Q3UP61_MOUSE GRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKLIKGPK MATCH CONSENSUS ????????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE GLGFSIAGGVGNQHVPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNNMYLEEVMHEDA Q4SFK1_TETNG Q4SFK1_TETNG GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNNVCLEDVMHEDA A4IHB8_XENTR A4IHB8_XENTR GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDLRLQIGDKILAVNNVGLEDVMHEDA A9JRI4_XENTR A9JRI4_XENTR GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDLRLQIGDKILAVNNVGLEDVMHEDA Q0IHR6_XENTR Q0IHR6_XENTR GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDLRLQIGDKILAVNNVGLEDVMHEDA B7Z3U2_HUMAN B7Z3U2_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA B7Z4H2_HUMAN B7Z4H2_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA DLG4_MOUSE DLG4_MOUSE GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA DLG4_RAT DLG4_RAT GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA B7Z647_HUMAN B7Z647_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA B9EGL1_HUMAN B9EGL1_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA DLG4_HUMAN DLG4_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA Q3ZCU5_HUMAN Q3ZCU5_HUMAN -------GGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA Q4SLA0_TETNG Q4SLA0_TETNG GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAQKDGRLQVGDRLLMVNNYGLEEVSHEEA A2BGZ1_DANRE A2BGZ1_DANRE GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEA DLG2_DANRE DLG2_DANRE GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEA Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN ---------------------------------------------MVNNYSLEEVTHEEA B7Z2T4_HUMAN B7Z2T4_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA DLG2_MOUSE DLG2_MOUSE GLGFSIAGGVGDQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA DLG2_RAT DLG2_RAT GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA B7Z395_HUMAN B7Z395_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA A8MVF1_HUMAN A8MVF1_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA DLG2_HUMAN DLG2_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA Q4RP82_TETNG Q4RP82_TETNG ------GGGLGSK------AVYIPGM--------DEKAKGGER----------------- A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA DLG3_HUMAN DLG3_HUMAN GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA Q59FY1_HUMAN Q59FY1_HUMAN GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA DLG3_RAT DLG3_RAT GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA Q80TH1_MOUSE Q80TH1_MOUSE GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA Q52KF7_MOUSE Q52KF7_MOUSE GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA A2BEF1_MOUSE A2BEF1_MOUSE GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA DLG3_MOUSE DLG3_MOUSE GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA A2BEE9_MOUSE A2BEE9_MOUSE GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ----SVSRGHSKSHRP-------------------------------------------- DLG1_DANRE DLG1_DANRE GLGFSIAGGVGNQHIPGDNSIYITKIIEGGAAHKDGRLQIGDKLLAVNAVCLEEVTHEDA A2BHX2_DANRE A2BHX2_DANRE GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKLLAVNSSCLEEVTHEHA DLG1L_DANRE DLG1L_DANRE GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKLLAVNSSCLEEVTHEHA DLG1_RAT DLG1_RAT GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEA Q571K0_MOUSE Q571K0_MOUSE GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEA B9EIQ5_HUMAN B9EIQ5_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA B4DF78_HUMAN B4DF78_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA B4DGZ8_HUMAN B4DGZ8_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA DLG1_HUMAN DLG1_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA B4DGU1_HUMAN B4DGU1_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA Q59FC4_HUMAN Q59FC4_HUMAN GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA Q8N3T5_HUMAN Q8N3T5_HUMAN -------------HVTSN------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEA DLG1_MOUSE DLG1_MOUSE GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEA Q3UP61_MOUSE Q3UP61_MOUSE GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEA MATCH CONSENSUS ???????GG?G??H?P?????Y????????????D?????G?????VN???L??V?HE?A

DLG4_DANRE DLG4_DANRE VAALKNTGDVVFLRVAKTLHQHHHQDAYNPPDITSSYSPHMDMSDYPQALS--------- Q4SFK1_TETNG Q4SFK1_TETNG VGALKNTAEVVYLRVAKP-NNLFLTNSYNPPDLTSTYS-HMDTELSHPNYLGSDYPQALT A4IHB8_XENTR A4IHB8_XENTR VAALKNTSDIVYLKVAKP-TNVYLNDSYAPPDITTSYSQQLDSDLCHPSYLGPDYA-PIM A9JRI4_XENTR A9JRI4_XENTR VAALKNTSDIVYLKVAKP-TNVYLNDSYAPPDITTSYSQQLDSDLCHPSYLGPDYA-PIM Q0IHR6_XENTR Q0IHR6_XENTR VAALKNTSDIVYLKVAKP-TNVYLNDSYAPPDITTSYSQQLDSDLCHPSYLGPDYA-PIM B7Z3U2_HUMAN B7Z3U2_HUMAN VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMT B7Z4H2_HUMAN B7Z4H2_HUMAN VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAM DLG4_MOUSE DLG4_MOUSE VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAM DLG4_RAT DLG4_RAT VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAM B7Z647_HUMAN B7Z647_HUMAN VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAM B9EGL1_HUMAN B9EGL1_HUMAN VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMT DLG4_HUMAN DLG4_HUMAN VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAM Q3ZCU5_HUMAN Q3ZCU5_HUMAN VAALKNTYDVVYLKVAKP-SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAM Q4SLA0_TETNG Q4SLA0_TETNG VAILKNTSDVVYLKVGKP-TNVYLSDPYGPPDITHSSSSSSHPP---------------- A2BGZ1_DANRE A2BGZ1_DANRE VAILKNTSDVVYLKVGKP-TSVYLSDPYGPPDITHSFSPAMENHISSPGNNGTLEYKSSL DLG2_DANRE DLG2_DANRE VAILKNTSDVVYLKVGKP-TSVYLSDPYGPPDITHSFSPAMENHISSPGNNGTLEYKSSL Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN VAILKNTSEVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPMENHL-LSGNNGTLEYKTSL B7Z2T4_HUMAN B7Z2T4_HUMAN VAILKNTSEVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPMENHL-LSGNNGTLEYKTSL B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN VAILKNTSEVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPMENHL-LSGNNGTLEYKTSL DLG2_MOUSE DLG2_MOUSE VAILKNTSDVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPTENHL-LSGNNGTLEYKTSL DLG2_RAT DLG2_RAT VAILKNTSDVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPMENHL-LSGNNGTLEYKTSL B7Z395_HUMAN B7Z395_HUMAN VAILKNTSEVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPMENHL-LSGNNGTLEYKTSL A8MVF1_HUMAN A8MVF1_HUMAN VAILKNTSEVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPMENHL-LSGNNGTLEYKTSL DLG2_HUMAN DLG2_HUMAN VAILKNTSEVVYLKVGKP-TTIYMTDPYGPPDITHSYSPPMENHL-LSGNNGTLEYKTSL Q4RP82_TETNG Q4RP82_TETNG --------EVEELPLSRAMRVCHVHGQYLSVHVRSL------------------------ A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN VASLKNTSDMVYLKVAKP-GSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK DLG3_HUMAN DLG3_HUMAN VASLKNTSDMVYLKVAKP-GSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK Q59FY1_HUMAN Q59FY1_HUMAN VASLKNTSDMVYLKVAKP-GSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK DLG3_RAT DLG3_RAT VASLKNTSDMVYLKVAKP-GSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK Q80TH1_MOUSE Q80TH1_MOUSE VASLKNTSDMVYLKVAKP-GSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK Q52KF7_MOUSE Q52KF7_MOUSE VASLKNTSDMVYLKVAKP-GSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK A2BEF1_MOUSE A2BEF1_MOUSE VASLKNTSDMVYLKVAKP-GSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK DLG3_MOUSE DLG3_MOUSE VASLKNTSDMVYLKVAKP-GSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK A2BEE9_MOUSE A2BEE9_MOUSE VASLKNTSDMVYLKVAKP-GSIHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK A2BEF2_MOUSE A2BEF2_MOUSE ------------------------------------------------------------ B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG --------SVPYLQQAPP------------------------------------------ DLG1_DANRE DLG1_DANRE VAALKNTPDVVYLKVAKP-TSVFMNDSYAPPDVTSSYSQHMENHISTQSYLSQPLT---- A2BHX2_DANRE A2BHX2_DANRE VTALKNTPDVVYLKVAKP-NSVFMNDSFAPPDITNSYSQHMENHISPPSYLSQPLP---- DLG1L_DANRE DLG1L_DANRE VTALKNTPDVVYLKVAKP-NSVFMNDSFAPPDITNSYSQHMENHISPPSYLSQPLP---- DLG1_RAT DLG1_RAT VTALKNTSDFVYLKAAKP-TSMYINDGYAPPDITNSSSQSVDNHVSPSSYLGQT------ Q571K0_MOUSE Q571K0_MOUSE VTALKNTSDFVYLKVAKP----------------TTSSQSVDNHVSPSSCLGQT------ B9EIQ5_HUMAN B9EIQ5_HUMAN VTALKNTSDFVYLKVAKP-TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT------ B4DF78_HUMAN B4DF78_HUMAN VTALKNTSDFVYLKVAKP-TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT------ B4DGZ8_HUMAN B4DGZ8_HUMAN VTALKNTSDFVYLKVAKP-TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT------ DLG1_HUMAN DLG1_HUMAN VTALKNTSDFVYLKVAKP-TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT------ B4DGU1_HUMAN B4DGU1_HUMAN VTALKNTSDFVYLKVAKP-TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT------ Q59FC4_HUMAN Q59FC4_HUMAN VTALKNTSDFVYLKVAKP-TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT------ Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE VTALKNTSDFVYLKVAKP----------------TTSSQSVDNYVSPSSCLGQT------ DLG1_MOUSE DLG1_MOUSE VTALKNTSDFVYLKVAKP-TSMYINDGYAPPDITNSSSQSVDNHVSPSSCLGQT------ Q3UP61_MOUSE Q3UP61_MOUSE VTALKNTSDFVYLKVAKP-TSMYINDGYAPPDITNSSSQSVDNHVSPSSCLGQT------ MATCH CONSENSUS V??LKNT???VYL???KP??????????????????????????????????????????

DLG4_DANRE DLG4_DANRE ---PSSPR----RYSPIPKGLFLDDDISR------------------------------- Q4SFK1_TETNG Q4SFK1_TETNG ---PTSPS----RFSPVLHGMMGDDDIPR------------------------------- A4IHB8_XENTR A4IHB8_XENTR T--PTSPR----RYSPIPKELLGEEEVPR------------------------------- A9JRI4_XENTR A9JRI4_XENTR T--PTSPR----RYSPIPKELLGEEEVPR------------------------------- Q0IHR6_XENTR Q0IHR6_XENTR T--PTSPR----RYSPIPKELLGEEEVPR------------------------------- B7Z3U2_HUMAN B7Z3U2_HUMAN ---PTSPR----RYSPVAKDLLGEEDIPR------------------------------- B7Z4H2_HUMAN B7Z4H2_HUMAN T--PTSPR----RYSPVAKDLLGEEDIPR------------------------------- DLG4_MOUSE DLG4_MOUSE T--PTSPR----RYSPVAKDLLGEEDIPR------------------------------- DLG4_RAT DLG4_RAT T--PTSPR----RYSPVAKDLLGEEDIPR------------------------------- B7Z647_HUMAN B7Z647_HUMAN T--PTSPR----RYSPVAKDLLGEEDIPR------------------------------- B9EGL1_HUMAN B9EGL1_HUMAN ---PTSPR----RYSPVAKDLLGEEDIPR------------------------------- DLG4_HUMAN DLG4_HUMAN T--PTSPR----RYSPVAKDLLGEEDIPR------------------------------- Q3ZCU5_HUMAN Q3ZCU5_HUMAN T--PTSPR----RYSPVAKDLLGEEDIPR------------------------------- Q4SLA0_TETNG Q4SLA0_TETNG ---PSSQSPKMLKSSDSPELMYYLNCLYR------------------------------- A2BGZ1_DANRE A2BGZ1_DANRE P--PISPG----RYSPLPKHLLGEEDINRNPSLDEMEGHRFDSQHFQLR----------- DLG2_DANRE DLG2_DANRE P--PISPG----RYSPLPKHLLGEEDINRNPSLDEMEGHRFDSQHFQLR----------- Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN P--PISPG----RYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF B7Z2T4_HUMAN B7Z2T4_HUMAN P--PISPG----RYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN P--PISPG----RYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF DLG2_MOUSE DLG2_MOUSE P--PIPPG----RYSPIPKHMLGEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF DLG2_RAT DLG2_RAT P--PISPG----RYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF B7Z395_HUMAN B7Z395_HUMAN P--PISPG----RYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF A8MVF1_HUMAN A8MVF1_HUMAN P--PISPG----RYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF DLG2_HUMAN DLG2_HUMAN P--PISPG----RYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF Q4RP82_TETNG Q4RP82_TETNG P--EHTVR----RFRARSKRQ-----IPR------------------------------- A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN VSYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- DLG3_HUMAN DLG3_HUMAN VSYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- Q59FY1_HUMAN Q59FY1_HUMAN VSYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- DLG3_RAT DLG3_RAT VTYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- Q80TH1_MOUSE Q80TH1_MOUSE VTYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- Q52KF7_MOUSE Q52KF7_MOUSE VTYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- A2BEF1_MOUSE A2BEF1_MOUSE VTYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- DLG3_MOUSE DLG3_MOUSE VTYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- A2BEE9_MOUSE A2BEE9_MOUSE VTYPAPPQVPPTRYSPIPRHMLAEEDFTR------------------------------- A2BEF2_MOUSE A2BEF2_MOUSE ----------------------------R------------------------------- B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN ------------------------------------------------------------ Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ---------------PFPHH---------------------------------------- DLG1_DANRE DLG1_DANRE ---PATPS----RYSPVSKGMLGDDEITR------------------------------- A2BHX2_DANRE A2BHX2_DANRE ---PVHSG----RFSPTPKTTVGDDDVTR------------------------------- DLG1L_DANRE DLG1L_DANRE ---PVHSG----RFSPTPKTTVGDDDVTR------------------------------- DLG1_RAT DLG1_RAT ---PASPA----RYSPISKAVLGDDEITR------------------------------- Q571K0_MOUSE Q571K0_MOUSE ---PTSPA----RYSPISKAVLGDDEITR------------------------------- B9EIQ5_HUMAN B9EIQ5_HUMAN ---PASPA----RYSPVSKAVLGDDEITR------------------------------- B4DF78_HUMAN B4DF78_HUMAN ---PASPA----RYSPVSKAVLGDDEITR------------------------------- B4DGZ8_HUMAN B4DGZ8_HUMAN ---PASPA----RYSPVSKAVLGDDEITR------------------------------- DLG1_HUMAN DLG1_HUMAN ---PASPA----RYSPVSKAVLGDDEITR------------------------------- B4DGU1_HUMAN B4DGU1_HUMAN ---PASPA----RYSPVSKAVLGDDEITR------------------------------- Q59FC4_HUMAN Q59FC4_HUMAN ---PASPA----RYSPVSKAVLGDDEITR------------------------------- Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ---PTSPA----RYSPISKAVLGDDEITR------------------------------- DLG1_MOUSE DLG1_MOUSE ---PTSPA----RYSPISKAVLGDDEITR------------------------------- Q3UP61_MOUSE Q3UP61_MOUSE ---PTSPA----RYSPISKAVLGDDEITR------------------------------- MATCH CONSENSUS ???P????????R?SP????????????R???????????????????????????????

DLG4_DANRE DLG4_DANRE --------------------------------------------EPRRVVIHRGSTGLGF Q4SFK1_TETNG Q4SFK1_TETNG --------------------------------------------EPRRVLIHRGTTGLGF A4IHB8_XENTR A4IHB8_XENTR --------------------------------------------EPRRIVIHRGSTGLGF A9JRI4_XENTR A9JRI4_XENTR --------------------------------------------EPRRIVIHRGSTGLGF Q0IHR6_XENTR Q0IHR6_XENTR --------------------------------------------EPRRIVIHRGSTGLGF B7Z3U2_HUMAN B7Z3U2_HUMAN --------------------------------------------EPRRIVIHRGSTGLGF B7Z4H2_HUMAN B7Z4H2_HUMAN --------------------------------------------EPRRIVIHRGSTGLGF DLG4_MOUSE DLG4_MOUSE --------------------------------------------EPRRIVIHRGSTGLGF DLG4_RAT DLG4_RAT --------------------------------------------EPRRIVIHRGSTGLGF B7Z647_HUMAN B7Z647_HUMAN --------------------------------------------EPRRIVIHRGSTGLGF B9EGL1_HUMAN B9EGL1_HUMAN --------------------------------------------EPRRIVIHRGSTGLGF DLG4_HUMAN DLG4_HUMAN --------------------------------------------EPRRIVIHRGSTGLGF Q3ZCU5_HUMAN Q3ZCU5_HUMAN --------------------------------------------EPRRIVIHRGSTGLGF Q4SLA0_TETNG Q4SLA0_TETNG --------------------------------------------EPRKVVLHKGSTGLGF A2BGZ1_DANRE A2BGZ1_DANRE --------------------------------------------EPRKIVLHKGSTGLGF DLG2_DANRE DLG2_DANRE --------------------------------------------EPRKIVLHKGSTGLGF Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF B7Z2T4_HUMAN B7Z2T4_HUMAN LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF DLG2_MOUSE DLG2_MOUSE LLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGF DLG2_RAT DLG2_RAT LLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGF B7Z395_HUMAN B7Z395_HUMAN LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF A8MVF1_HUMAN A8MVF1_HUMAN LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF DLG2_HUMAN DLG2_HUMAN LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF Q4RP82_TETNG Q4RP82_TETNG --------------------------------------------EPRKVLLHKGSTGLGF A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN --------------------------------------------EPRKIILHKGSTGLGF DLG3_HUMAN DLG3_HUMAN --------------------------------------------EPRKIILHKGSTGLGF Q59FY1_HUMAN Q59FY1_HUMAN --------------------------------------------EPRKIILHKGSTGLGF DLG3_RAT DLG3_RAT --------------------------------------------EPRKIILHKGSTGLGF Q80TH1_MOUSE Q80TH1_MOUSE --------------------------------------------EPRKIILHKGSTGLGF Q52KF7_MOUSE Q52KF7_MOUSE --------------------------------------------EPRKIILHKGSTGLGF A2BEF1_MOUSE A2BEF1_MOUSE --------------------------------------------EPRKIILHKGSTGLGF DLG3_MOUSE DLG3_MOUSE --------------------------------------------EPRKIILHKGSTGLGF A2BEE9_MOUSE A2BEE9_MOUSE --------------------------------------------EPRKIILHKGSTGLGF A2BEF2_MOUSE A2BEF2_MOUSE --------------------------------------------EPRKIILHKGSTGLGF B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN --------------------------------------------EPRKIILHKGSTGLGF Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE --------------------------------------------EPRKIVLHRGTTGLGF A2BHX2_DANRE A2BHX2_DANRE --------------------------------------------EPRKVVLHRGTTGLGF DLG1L_DANRE DLG1L_DANRE --------------------------------------------EPRKVVLHRGTTGLGF DLG1_RAT DLG1_RAT --------------------------------------------EPRKVVLHRGSTGLGF Q571K0_MOUSE Q571K0_MOUSE --------------------------------------------EPRKVVLHRGSTGLGF B9EIQ5_HUMAN B9EIQ5_HUMAN --------------------------------------------EPRKVVLHRGSTGLGF B4DF78_HUMAN B4DF78_HUMAN --------------------------------------------EPRKVVLHRGSMGLGF B4DGZ8_HUMAN B4DGZ8_HUMAN --------------------------------------------EPRKVVLHRGSTGLGF DLG1_HUMAN DLG1_HUMAN --------------------------------------------EPRKVVLHRGSTGLGF B4DGU1_HUMAN B4DGU1_HUMAN --------------------------------------------EPRKVVLHRGSTGLGF Q59FC4_HUMAN Q59FC4_HUMAN --------------------------------------------EPRKVVLHRGSTGLGF Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE --------------------------------------------EPRKVVLHRGSTGLGF DLG1_MOUSE DLG1_MOUSE --------------------------------------------EPRKVVLHRGSTGLGF Q3UP61_MOUSE Q3UP61_MOUSE --------------------------------------------EPRKVVLHRGSTGLGF MATCH CONSENSUS ????????????????????????????????????????????EPR????H?G?TGLGF

DLG4_DANRE DLG4_DANRE NIVGGEDGEGIFISFILAGGAADLSGELRKGDQILSVNGVDLRHATHEQAAAALKNAGQT Q4SFK1_TETNG Q4SFK1_TETNG NIVGGEDGEGIFISFILAGGPADLSGELHKGDQILSVNGVDLRMATHEQAAAALKNAGQT A4IHB8_XENTR A4IHB8_XENTR NIVGGEDGEGIFISFILAGGPADLSGALRKGDQIMSVNGVDLRNATHEQAALALKNAGQT A9JRI4_XENTR A9JRI4_XENTR NIVGGEDGEGIFISFILAGGPADLSGALRKGDQIMSVNGVDLRNATHEQAALALKNAGQT Q0IHR6_XENTR Q0IHR6_XENTR NIVGGEDGEGIFISFILAGGPADLSGALRKGDQIMSVNGVDLRNATHEQAALALKNAGQT B7Z3U2_HUMAN B7Z3U2_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT B7Z4H2_HUMAN B7Z4H2_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT DLG4_MOUSE DLG4_MOUSE NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT DLG4_RAT DLG4_RAT NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT B7Z647_HUMAN B7Z647_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT B9EGL1_HUMAN B9EGL1_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT DLG4_HUMAN DLG4_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT Q3ZCU5_HUMAN Q3ZCU5_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT Q4SLA0_TETNG Q4SLA0_TETNG NIVGGEDGEGIFVSFILAGGPADLSGELKRGDQILSVNGIDLRGATHEQAAVALKGAGQV A2BGZ1_DANRE A2BGZ1_DANRE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQT DLG2_DANRE DLG2_DANRE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQT Q5H9Q4_HUMAN Q5H9Q4_HUMAN ------------------------------------------------------------ B7Z646_HUMAN B7Z646_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT B7Z2T4_HUMAN B7Z2T4_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT B7Z640_HUMAN B7Z640_HUMAN ------------------------------------------------------------ B7Z264_HUMAN B7Z264_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT DLG2_MOUSE DLG2_MOUSE NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT DLG2_RAT DLG2_RAT NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT B7Z395_HUMAN B7Z395_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT A8MVF1_HUMAN A8MVF1_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT DLG2_HUMAN DLG2_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT Q4RP82_TETNG Q4RP82_TETNG NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQT A5PKT0_DANRE A5PKT0_DANRE ------------------------------------------------------------ B0R131_DANRE B0R131_DANRE ------------------------------------------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS DLG3_HUMAN DLG3_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS Q59FY1_HUMAN Q59FY1_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS DLG3_RAT DLG3_RAT NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS Q80TH1_MOUSE Q80TH1_MOUSE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS Q52KF7_MOUSE Q52KF7_MOUSE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS A2BEF1_MOUSE A2BEF1_MOUSE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS DLG3_MOUSE DLG3_MOUSE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS A2BEE9_MOUSE A2BEE9_MOUSE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS A2BEF2_MOUSE A2BEF2_MOUSE NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS B4E0H1_HUMAN B4E0H1_HUMAN ------------------------------------------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS Q4SWH8_TETNG Q4SWH8_TETNG ------------------------------------------------------------ Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------------------------------------ DLG1_DANRE DLG1_DANRE NIVGGEDGEGIFISFILAGGPADLCGELRKGDRIVSVNGVDLRSATHEQAAAALKNAGQT A2BHX2_DANRE A2BHX2_DANRE NIVGGEDGEGIFISFILAGGPADLCGELRKGDRLVSVNGIDLRGATHEQAAAALKNAGQT DLG1L_DANRE DLG1L_DANRE NIVGGEDGEGIFISFILAGGPADLCGELRKGDRLVSVNGIDLRGATHEQAAAALKNAGQT DLG1_RAT DLG1_RAT NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA Q571K0_MOUSE Q571K0_MOUSE NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA B9EIQ5_HUMAN B9EIQ5_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA B4DF78_HUMAN B4DF78_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA B4DGZ8_HUMAN B4DGZ8_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA DLG1_HUMAN DLG1_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA B4DGU1_HUMAN B4DGU1_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA Q59FC4_HUMAN Q59FC4_HUMAN NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA DLG1_MOUSE DLG1_MOUSE NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA Q3UP61_MOUSE Q3UP61_MOUSE NIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA MATCH CONSENSUS NIVGGEDGEGIF?SFILAGGPADLSGEL??GD?I?SVN???LR?A?HEQAA?ALK?AGQ?

DLG4_DANRE DLG4_DANRE VTIITQYRPEEYSRFEAKIHDLREQLMNSSLVSAAASLR---SGKRSFFIR-ALFDYDKT Q4SFK1_TETNG Q4SFK1_TETNG VTIIAQYRPDEYSRFEAKIHDLREQLMNSSMGSGTTTLR--SNPKRGFYIR-ALFDYDKT A4IHB8_XENTR A4IHB8_XENTR VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGSASLHNANGAKRGFYIR-ALFDYDKT A9JRI4_XENTR A9JRI4_XENTR VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGSASLHNANGAKRGFYIR-ALFDYDKT Q0IHR6_XENTR Q0IHR6_XENTR VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGSASLHNANGAKRGFYIR-ALFDYDKT B7Z3U2_HUMAN B7Z3U2_HUMAN VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT B7Z4H2_HUMAN B7Z4H2_HUMAN VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT DLG4_MOUSE DLG4_MOUSE VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT DLG4_RAT DLG4_RAT VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT B7Z647_HUMAN B7Z647_HUMAN VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT B9EGL1_HUMAN B9EGL1_HUMAN VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT DLG4_HUMAN DLG4_HUMAN VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT Q3ZCU5_HUMAN Q3ZCU5_HUMAN VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLR--SNPKRGFYIR-ALFDYDKT Q4SLA0_TETNG Q4SLA0_TETNG VTIVAQYRPEEYGRFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-ALFDYEKS A2BGZ1_DANRE A2BGZ1_DANRE VTIIAQYRPEEYGRFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-ALFDYERA DLG2_DANRE DLG2_DANRE VTIIAQYRPEEYGRFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-ALFDYERA Q5H9Q4_HUMAN Q5H9Q4_HUMAN -------------------------MMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS B7Z646_HUMAN B7Z646_HUMAN VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS B7Z2T4_HUMAN B7Z2T4_HUMAN VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS B7Z640_HUMAN B7Z640_HUMAN -------------------------MMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS B7Z264_HUMAN B7Z264_HUMAN VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS DLG2_MOUSE DLG2_MOUSE VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS DLG2_RAT DLG2_RAT VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS B7Z395_HUMAN B7Z395_HUMAN VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS A8MVF1_HUMAN A8MVF1_HUMAN VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS DLG2_HUMAN DLG2_HUMAN VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR--TNQKRSLYVR-AMFDYDKS Q4RP82_TETNG Q4RP82_TETNG VTIIAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT A5PKT0_DANRE A5PKT0_DANRE -------------------------MMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT B0R131_DANRE B0R131_DANRE -------------------------MMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT Q5JUW8_HUMAN Q5JUW8_HUMAN VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT DLG3_HUMAN DLG3_HUMAN VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT Q59FY1_HUMAN Q59FY1_HUMAN VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT DLG3_RAT DLG3_RAT VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT Q80TH1_MOUSE Q80TH1_MOUSE VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT Q52KF7_MOUSE Q52KF7_MOUSE VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT A2BEF1_MOUSE A2BEF1_MOUSE VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT DLG3_MOUSE DLG3_MOUSE VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT A2BEE9_MOUSE A2BEE9_MOUSE VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT A2BEF2_MOUSE A2BEF2_MOUSE VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT B4E0H1_HUMAN B4E0H1_HUMAN -------------------------MMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT Q5JUW6_HUMAN Q5JUW6_HUMAN VTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR--TSEKRSLYVR-ALFDYDRT Q4SWH8_TETNG Q4SWH8_TETNG ----------EYSRGEAKIHDLREQMMTSSISSSSTSLR--STQKRTLYVREPLFDYDGS Q4T7S4_TETNG Q4T7S4_TETNG ------------------------------LCESAGAFR--------LLV--GLEELEKD DLG1_DANRE DLG1_DANRE VTIIAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRTLYVR-ALFDYDIT A2BHX2_DANRE A2BHX2_DANRE VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT DLG1L_DANRE DLG1L_DANRE VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT DLG1_RAT DLG1_RAT VTIVAQYRPEEYSRFEAKIHDLRETMMNSSVSSGSGSLR--TSQKRSLYVR-ALFDYDKT Q571K0_MOUSE Q571K0_MOUSE VTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLR--TSQKRSLYVS--------- B9EIQ5_HUMAN B9EIQ5_HUMAN VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT B4DF78_HUMAN B4DF78_HUMAN VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT B4DGZ8_HUMAN B4DGZ8_HUMAN VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT DLG1_HUMAN DLG1_HUMAN VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT B4DGU1_HUMAN B4DGU1_HUMAN VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT Q59FC4_HUMAN Q59FC4_HUMAN VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR--TSQKRSLYVR-ALFDYDKT Q8N3T5_HUMAN Q8N3T5_HUMAN -----------------------------------------ASDSESSYLI--------- Q3TPP5_MOUSE Q3TPP5_MOUSE VTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLR--TSQKRSLYVR-ALFDYDKT DLG1_MOUSE DLG1_MOUSE VTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLR--TSQKRSLYVR-ALFDYDKT Q3UP61_MOUSE Q3UP61_MOUSE VTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLR--TSQKRSLYVR-ALFDYDKT MATCH : CONSENSUS VTI?AQY?PE?Y?RFE?KIHDLREQ?MN?S??SG??SLR?????KR??Y?R?A?FDYD??

DLG4_DANRE DLG4_DANRE -ADGGFLSQAVSFRFGDVLQVFDCSDEEWWQAGKLA-PHGELEETGYIPSKRRVERKE-W Q4SFK1_TETNG Q4SFK1_TETNG -ADCGFLSQALGFKFGDVLHVLDCGDEEWWQARKVS-PQNEAEEVGFIPSKHRVERKE-W A4IHB8_XENTR A4IHB8_XENTR -RDCGFLSQALSFKFGDILHVIDATDEEWWQARRVL-PEGE--EIGFIPSKRRVERRE-W A9JRI4_XENTR A9JRI4_XENTR -RDCGFLSQALSFKFGDILHVIDATDEEWWQARRVL-PEGE--EIGFIPSKRRVERRE-W Q0IHR6_XENTR Q0IHR6_XENTR -RDCGFLSQALSFKFGDILHVIDATDEEWWQARRVL-PEGE--EIGFIPSKRRVERRE-W B7Z3U2_HUMAN B7Z3U2_HUMAN -KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVH-SDSETDDIGFIPSKRRVERRE-W B7Z4H2_HUMAN B7Z4H2_HUMAN -KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVH-SDSETDDIGFIPSRRRVERRE-W DLG4_MOUSE DLG4_MOUSE -KDCGFLSQALSFHFGDVLHVIDASDEEWWQARRVH-SDSETDDIGFIPSKRRVERRE-W DLG4_RAT DLG4_RAT -KDCGFLSQALSFRFGDVLHVIDAGDEEWWQARRVH-SDSETDDIGFIPSKRRVERRE-W B7Z647_HUMAN B7Z647_HUMAN -KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVH-SDSETDDIGFIPSKRRVERRE-W B9EGL1_HUMAN B9EGL1_HUMAN -KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVH-SDSETDDIGFIPSKRRVERRE-W DLG4_HUMAN DLG4_HUMAN -KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVH-SDSETDDIGFIPSKRRVERRE-W Q3ZCU5_HUMAN Q3ZCU5_HUMAN -KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVH-SDSETDDIGFIPSKRRVERRE-W Q4SLA0_TETNG Q4SLA0_TETNG -RDSGLPSQGLSFKYGDILHVINASDDEWWQARRVT-PHGDSEEMGVIPSKRRVERKE-R A2BGZ1_DANRE A2BGZ1_DANRE -KDSGLPSQGLSFRYGDILHVINASDDEWWQARRVT-PEGDSEEMGVIPSKRRVERKE-R DLG2_DANRE DLG2_DANRE -KDSGLPSQGLSFRYGDILHVINASDDEWWQARRVT-PEGDSEEMGVIPSKRRVERKE-R Q5H9Q4_HUMAN Q5H9Q4_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R B7Z646_HUMAN B7Z646_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R B7Z2T4_HUMAN B7Z2T4_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R B7Z640_HUMAN B7Z640_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R B7Z264_HUMAN B7Z264_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R DLG2_MOUSE DLG2_MOUSE -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVI-LDGDSEEMGVIPSKRRVERKE-R DLG2_RAT DLG2_RAT -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVI-LDGDSEEMGVIPSKRRVERKE-R B7Z395_HUMAN B7Z395_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R A8MVF1_HUMAN A8MVF1_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R DLG2_HUMAN DLG2_HUMAN -KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVM-LEGDSEEMGVIPSKRRVERKE-R Q4RP82_TETNG Q4RP82_TETNG -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R A5PKT0_DANRE A5PKT0_DANRE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R B0R131_DANRE B0R131_DANRE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R Q5JUW8_HUMAN Q5JUW8_HUMAN -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R DLG3_HUMAN DLG3_HUMAN -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R Q59FY1_HUMAN Q59FY1_HUMAN -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R DLG3_RAT DLG3_RAT -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R Q80TH1_MOUSE Q80TH1_MOUSE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R Q52KF7_MOUSE Q52KF7_MOUSE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R A2BEF1_MOUSE A2BEF1_MOUSE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R DLG3_MOUSE DLG3_MOUSE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R A2BEE9_MOUSE A2BEE9_MOUSE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R A2BEF2_MOUSE A2BEF2_MOUSE -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R B4E0H1_HUMAN B4E0H1_HUMAN -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R Q5JUW6_HUMAN Q5JUW6_HUMAN -RDSCLPSQGLSFSYGDILHVINASDDEWWQARLVT-PHGESEQIGVIPSKKRVEKKE-R Q4SWH8_TETNG Q4SWH8_TETNG VPDPSTANQALSFHFGDILHVSSAGEEEWWPARHLSPPPPNCPEVGVIPSRRRSGSKSFK Q4T7S4_TETNG Q4T7S4_TETNG --------------FVTLCFVVIAE----------------------------------- DLG1_DANRE DLG1_DANRE --------------------------------KTVK-FNSKSRDKASLNDKR-------R A2BHX2_DANRE A2BHX2_DANRE -KDSGLPSQGLNFKFGDILHVVNASDDEWWQARQVT-AQGEVEEMGVIPSKRRVEKKE-R DLG1L_DANRE DLG1L_DANRE -KDSGLPSQGLNFKFGDILHVVNASDDEWWQARQVT-AQGEVEEMGVIPSKRRVEKKE-R DLG1_RAT DLG1_RAT -KDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R Q571K0_MOUSE Q571K0_MOUSE -LEPSLI----------------------------------------------------M B9EIQ5_HUMAN B9EIQ5_HUMAN -KDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R B4DF78_HUMAN B4DF78_HUMAN -KDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R B4DGZ8_HUMAN B4DGZ8_HUMAN -KDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R DLG1_HUMAN DLG1_HUMAN -KDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R B4DGU1_HUMAN B4DGU1_HUMAN -KDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R Q59FC4_HUMAN Q59FC4_HUMAN -KDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R Q8N3T5_HUMAN Q8N3T5_HUMAN ------------------------------------------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE -KDSGLPSQGLNFRFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R DLG1_MOUSE DLG1_MOUSE -KDSGLPSQGLNFRFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R Q3UP61_MOUSE Q3UP61_MOUSE -KDSGLPSQGLNFRFGDILHVINASDDEWWQARQVT-PDGESDEVGVIPSKRRVEKKE-R MATCH CONSENSUS ??D????SQ?L?F??GD?LHVI?ASD?EWWQAR?V??????????G?IPSK?RVE??E??

DLG4_DANRE DLG4_DANRE SRLKTRGREPVSG----------------------------------------------- Q4SFK1_TETNG Q4SFK1_TETNG SRGNTKE---RVGTLSRGGSLPVFHMCKSLL--------------------LFLLQDHGR A4IHB8_XENTR A4IHB8_XENTR SRLKDRSSGGS------------------------------------------------- A9JRI4_XENTR A9JRI4_XENTR SRLKDRSSGGS------------------------------------------------- Q0IHR6_XENTR Q0IHR6_XENTR SRLKDRSSGGS------------------------------------------------- B7Z3U2_HUMAN B7Z3U2_HUMAN SRLKAKDWGSSSGS---------------------------------------------- B7Z4H2_HUMAN B7Z4H2_HUMAN SRLKAKDWGSSSGS---------------------------------------------- DLG4_MOUSE DLG4_MOUSE SRLKAKDWGSSSGS---------------------------------------------- DLG4_RAT DLG4_RAT SRLKAKDWGSSSGS---------------------------------------------- B7Z647_HUMAN B7Z647_HUMAN SRLKAKDWGSSSGS---------------------------------------------- B9EGL1_HUMAN B9EGL1_HUMAN SRLKAKDWGSSSGS---------------------------------------------- DLG4_HUMAN DLG4_HUMAN SRLKAKDWGSSSGS---------------------------------------------- Q3ZCU5_HUMAN Q3ZCU5_HUMAN SRLKAKDWGSSSGS---------------------------------------------- Q4SLA0_TETNG Q4SLA0_TETNG ARLKTVKFNAKPGSFDSKGSFNDKRKKNFTFTRKFP---------------FYKNKEGEQ A2BGZ1_DANRE A2BGZ1_DANRE ARLKTVKFNAKPGSLDSKGSFSEKRRKNFIFSRKFPF--------------YKNKDADEQ DLG2_DANRE DLG2_DANRE ARLKTVKFNAKPGSLDSKGSFSEKRRKNFIFSRKFPF--------------YKNKDADEQ Q5H9Q4_HUMAN Q5H9Q4_HUMAN ARLKTVKFNAKPGVIDSKGDIPGLGDEGY------------------------------- B7Z646_HUMAN B7Z646_HUMAN ARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKT------------------LKHVSSNAS B7Z2T4_HUMAN B7Z2T4_HUMAN ARLKTVKFNAKPGVIDSKGDIPGLGDDGY------------------------------- B7Z640_HUMAN B7Z640_HUMAN ARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKT------------------LKHVSSNAS B7Z264_HUMAN B7Z264_HUMAN ARLKTVKFNAKPGVIDSKGDIPGLGDDGY------------------------------- DLG2_MOUSE DLG2_MOUSE ARLKTVKFNAKPGVIDSKGDIPGLGDDGY------------------------------- DLG2_RAT DLG2_RAT ARLKTVKFNAKPGVIDSKGDIPGLGDDGY------------------------------- B7Z395_HUMAN B7Z395_HUMAN ARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF--------------YKNKEQSEQ A8MVF1_HUMAN A8MVF1_HUMAN ARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF--------------YKNKEQSEQ DLG2_HUMAN DLG2_HUMAN ARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF--------------YKNKEQSEQ Q4RP82_TETNG Q4RP82_TETNG ARLKTVKFHARTGMIESNRSKENIVQELVESEQC-----------------LTSNSDSES A5PKT0_DANRE A5PKT0_DANRE ARLKTVKFHARTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVETEQCLTSNTS B0R131_DANRE B0R131_DANRE ARLKTVKFHARTGMIESNRDFPGLSDDFYGSKS------------------LKCLTSNTS Q5JUW8_HUMAN Q5JUW8_HUMAN ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------LKGVTSNTS DLG3_HUMAN DLG3_HUMAN ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------L-------- Q59FY1_HUMAN Q59FY1_HUMAN ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------L-------- DLG3_RAT DLG3_RAT ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------LKGVTSNTS Q80TH1_MOUSE Q80TH1_MOUSE ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNL-------------------------- Q52KF7_MOUSE Q52KF7_MOUSE ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------L-------- A2BEF1_MOUSE A2BEF1_MOUSE ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------LKGVTSNTS DLG3_MOUSE DLG3_MOUSE ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------LKGVTSNTS A2BEE9_MOUSE A2BEE9_MOUSE ARLKTVKFHARTGMIESNRDFPGLSDDYYGAKN------------------L-------- A2BEF2_MOUSE A2BEF2_MOUSE ARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQENSIQEQGVTSNTS B4E0H1_HUMAN B4E0H1_HUMAN ARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTS Q5JUW6_HUMAN Q5JUW6_HUMAN ARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTS Q4SWH8_TETNG Q4SWH8_TETNG PTFSTAGKAAGVGMNPALASIFVISQEHRAEKKERSRLKTV----------RVTRSQDRS Q4T7S4_TETNG Q4T7S4_TETNG -----------------------------------------------------HVTSNAS DLG1_DANRE DLG1_DANRE KTLFSRKFLFSKNKDSGEQDTSDV---------------------------DQHVTSNAS A2BHX2_DANRE A2BHX2_DANRE ARLKTVKFNSKSR---EKGDNPDDMLSKGQS----------------------------- DLG1L_DANRE DLG1L_DANRE ARLKTVKFNSKSR---EKGDNPDDMLSKGQS----------------------------- DLG1_RAT DLG1_RAT ARLKTVKFNSKTR--GDKGEIPDDMGSKG----------------------LKHVTSNAS Q571K0_MOUSE Q571K0_MOUSE TRLRTAGF---------------------------------------------------- B9EIQ5_HUMAN B9EIQ5_HUMAN ARLKTVKFNSKTR---DKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNAS B4DF78_HUMAN B4DF78_HUMAN ARLKTVKFNSKTR---DKGEIPDDMGSKG----------------------LKHVTSNAS B4DGZ8_HUMAN B4DGZ8_HUMAN ARLKTVKFNSKTR---DKGEIPDDMGSKG----------------------LKHVTSNAS DLG1_HUMAN DLG1_HUMAN ARLKTVKFNSKTR---DKGEIPDDMGSKG----------------------LKHVTSNAS B4DGU1_HUMAN B4DGU1_HUMAN ARLKTVKFNSKTR---DKGEIPDDMGSKG----------------------LKHVTSNAS Q59FC4_HUMAN Q59FC4_HUMAN ARLKTVKFNSKTR---DKGEIPDDMGSKG----------------------LKHVTSNAS Q8N3T5_HUMAN Q8N3T5_HUMAN --LITDEYGCSKG----------------------------------------------- Q3TPP5_MOUSE Q3TPP5_MOUSE ARLKTVKFNS-------------------------------------------------- DLG1_MOUSE DLG1_MOUSE ARLKTVKFNSKTR--GDKGEIPDDMGSKG----------------------LKHVTSNAS Q3UP61_MOUSE Q3UP61_MOUSE ARLKTVKFNSKTR--GDKGEIPDDMGSKG----------------------LKHVTSNAS MATCH CONSENSUS ?RLK????????????????????????????????????????????????????????

DLG4_DANRE DLG4_DANRE -------------R---------SDYIVSYETVTQS------------------------ Q4SFK1_TETNG Q4SFK1_TETNG DTLSTQ-------G-----GR--DKSSHSYETVTQVEGRTVETCLLSSVSGFLLLTGLSS A4IHB8_XENTR A4IHB8_XENTR -------------Q-----SR--EETVLSYEVVVHM------------------------ A9JRI4_XENTR A9JRI4_XENTR -------------Q-----SR--EETVLSYEVVVHM------------------------ Q0IHR6_XENTR Q0IHR6_XENTR -------------Q-----SR--EETVLSYEVVVHM------------------------ B7Z3U2_HUMAN B7Z3U2_HUMAN -------------Q-----GR--EDSVLSYETVTQM------------------------ B7Z4H2_HUMAN B7Z4H2_HUMAN -------------Q-----GR--EDSVLSYETVTQM------------------------ DLG4_MOUSE DLG4_MOUSE -------------Q-----GR--EDSVLSYETVTQM------------------------ DLG4_RAT DLG4_RAT -------------Q-----GR--EDSVLSYETVTQM------------------------ B7Z647_HUMAN B7Z647_HUMAN -------------Q-----GR--EDSVLSYETVTQM------------------------ B9EGL1_HUMAN B9EGL1_HUMAN -------------Q-----GR--EDSVLSYETVTQM------------------------ DLG4_HUMAN DLG4_HUMAN -------------Q-----GR--EDSVLSYETVTQM------------------------ Q3ZCU5_HUMAN Q3ZCU5_HUMAN -------------Q-----GR--EDSVLSYETVTQM------------------------ Q4SLA0_TETNG Q4SLA0_TETNG DGSDSE-------R-----SQ--DDVILSYEPVLRQ------------------------ A2BGZ1_DANRE A2BGZ1_DANRE DGSDSE-------R-----SQ--EELILSYEPVIRQ------------------------ DLG2_DANRE DLG2_DANRE DGSDSE-------R-----SQ--EELILSYEPVIRQ------------------------ Q5H9Q4_HUMAN Q5H9Q4_HUMAN -GTKTL-------R-----GQ--EDLILSYEPVTRQ------------------------ B7Z646_HUMAN B7Z646_HUMAN DSESSY-------R-----GQ--EDLILSYEPVTRQ------------------------ B7Z2T4_HUMAN B7Z2T4_HUMAN -GTKTL-------R-----GQ--EDLILSYEPVTRQ------------------------ B7Z640_HUMAN B7Z640_HUMAN DSESSY-------R-----GQ--EDLILSYEPVTRQ------------------------ B7Z264_HUMAN B7Z264_HUMAN -GTKTL-------R-----GQ--EDLILSYEPVTRQ------------------------ DLG2_MOUSE DLG2_MOUSE -GTKTL-------R-----GQ--EDLILSYEPVTRQ------------------------ DLG2_RAT DLG2_RAT -GTKTL-------R-----GQ--EDLILSYEPVTRQ------------------------ B7Z395_HUMAN B7Z395_HUMAN ETSDPE-------R-----GQ--EDLILSYEPVTRQ------------------------ A8MVF1_HUMAN A8MVF1_HUMAN ETSDPE-------R-----GQ--EDLILSYEPVTRQ------------------------ DLG2_HUMAN DLG2_HUMAN ETSDPE-------R-----GQ--EDLILSYEPVTRQ------------------------ Q4RP82_TETNG Q4RP82_TETNG SSSESRCRVGPGFR-----GEPPAKAMAHFDLLSLQRGRRTPSFPTNQSSGRKVSERLLD A5PKT0_DANRE A5PKT0_DANRE DSESSS-------K-----GQ--EDTILSYEPVIRQ------------------------ B0R131_DANRE B0R131_DANRE DSESSS-------K-----GQ--EDTILSYEPVIRQ------------------------ Q5JUW8_HUMAN Q5JUW8_HUMAN DSESSS-------K-----GQ--EDAILSYEPVTRQ------------------------ DLG3_HUMAN DLG3_HUMAN -------------K-----GQ--EDAILSYEPVTRQ------------------------ Q59FY1_HUMAN Q59FY1_HUMAN -------------K-----GQ--EDAILSYEPVTRQ------------------------ DLG3_RAT DLG3_RAT DSESSS-------K-----GQ--EDAILSYEPVTRQ------------------------ Q80TH1_MOUSE Q80TH1_MOUSE -------------K-----GQ--EDAILSYEPVTRQ------------------------ Q52KF7_MOUSE Q52KF7_MOUSE -------------K-----GQ--EDAILSYEPVTRQ------------------------ A2BEF1_MOUSE A2BEF1_MOUSE DSESSS-------K-----GQ--EDAILSYEPVTRQ------------------------ DLG3_MOUSE DLG3_MOUSE DSESSS-------K-----GQ--EDAILSYEPVTRQ------------------------ A2BEE9_MOUSE A2BEE9_MOUSE -------------K-----GQ--EDAILSYEPVTRQ------------------------ A2BEF2_MOUSE A2BEF2_MOUSE DSESSS-------K-----GQ--EDAILSYEPVTRQ------------------------ B4E0H1_HUMAN B4E0H1_HUMAN DSESSS-------K-----GQ--EDAILSYEPVTRQ------------------------ Q5JUW6_HUMAN Q5JUW6_HUMAN DSESSS-------K-----GQ--EDAILSYEPVTRQ------------------------ Q4SWH8_TETNG Q4SWH8_TETNG DQDDKV-------------GQ--EETFLTYQPVMQQ------------------------ Q4T7S4_TETNG Q4T7S4_TETNG DSESSY-------R-----GQ--DEYVLSYEPVLQQ------------------------ DLG1_DANRE DLG1_DANRE DSESSF-------R-----GQ--EDYVLSYETVTQQ------------------------ A2BHX2_DANRE A2BHX2_DANRE -------------------GQ--EEYVLSYEPVSQQ------------------------ DLG1L_DANRE DLG1L_DANRE -------------------GQ--EEYVLSYEPVSQQ------------------------ DLG1_RAT DLG1_RAT DSESSYHEYGCSKG-----GQ--EEYVLSYEPVNQQ------------------------ Q571K0_MOUSE Q571K0_MOUSE ------------------------------------------------------------ B9EIQ5_HUMAN B9EIQ5_HUMAN DSESSY-------R-----GQ--EEYVLSYEPVNQQ------------------------ B4DF78_HUMAN B4DF78_HUMAN DSESSY-------R-----GQ--EEYVLSYEPVNQQ------------------------ B4DGZ8_HUMAN B4DGZ8_HUMAN DSESSY-------R-----GQ--EEYVLSYEPVNQQ------------------------ DLG1_HUMAN DLG1_HUMAN DSESSY-------R-----GQ--EEYVLSYEPVNQQ------------------------ B4DGU1_HUMAN B4DGU1_HUMAN DSESSYLILITDEYGCSKGGQ--EEYVLSYEPVNQQ------------------------ Q59FC4_HUMAN Q59FC4_HUMAN DSESSYLILITDEYGCSKGGQ--EEYVLSYEPVNQQ------------------------ Q8N3T5_HUMAN Q8N3T5_HUMAN -------------------GQ--EEYVLSYEPVNQQ------------------------ Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE DSESSY-------R-----GQ--EEYVLSYEPVNQQ------------------------ Q3UP61_MOUSE Q3UP61_MOUSE DSESSY-------R-----GQ--EEYVLSYEPVNQQ------------------------ MATCH CONSENSUS ???????????????????G???E???LSYE?V???????????????????????????

DLG4_DANRE DLG4_DANRE --E------------------VHYARPVIILGPSKDRVNDDLLSEFPDKFGSCVP----- Q4SFK1_TETNG Q4SFK1_TETNG LPE------------------VHYARPIIILGPVKDRINDDLLSEFPDKFGSCVP----- A4IHB8_XENTR A4IHB8_XENTR --E------------------VHYARPIIILGPGKDRVNDDLLSEFPDKFGSCVP----- A9JRI4_XENTR A9JRI4_XENTR --E------------------VHYARPIIILGPGKDRVNDDLLSEFPDKFGSCVP----- Q0IHR6_XENTR Q0IHR6_XENTR --E------------------VHYARPIIILGPGKDRVNDDLLSEFPDKFGSCVP----- B7Z3U2_HUMAN B7Z3U2_HUMAN --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- B7Z4H2_HUMAN B7Z4H2_HUMAN --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- DLG4_MOUSE DLG4_MOUSE --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- DLG4_RAT DLG4_RAT --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- B7Z647_HUMAN B7Z647_HUMAN --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- B9EGL1_HUMAN B9EGL1_HUMAN --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- DLG4_HUMAN DLG4_HUMAN --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- Q3ZCU5_HUMAN Q3ZCU5_HUMAN --E------------------VHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP----- Q4SLA0_TETNG Q4SLA0_TETNG --E------------------INYARPVIILGPMKDRINDDLISEFPEKFGSCVP----- A2BGZ1_DANRE A2BGZ1_DANRE --E------------------INYARPVIILGPMKDRINDDLISEFPDKFGSCVPPANSS DLG2_DANRE DLG2_DANRE --E------------------INYARPVIILGPMKDRINDDLISEFPDKFGSCVPPANSS Q5H9Q4_HUMAN Q5H9Q4_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDEFGSCVP----- B7Z646_HUMAN B7Z646_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- B7Z2T4_HUMAN B7Z2T4_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- B7Z640_HUMAN B7Z640_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- B7Z264_HUMAN B7Z264_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- DLG2_MOUSE DLG2_MOUSE --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- DLG2_RAT DLG2_RAT --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- B7Z395_HUMAN B7Z395_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- A8MVF1_HUMAN A8MVF1_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- DLG2_HUMAN DLG2_HUMAN --E------------------INYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- Q4RP82_TETNG Q4RP82_TETNG EAKGRVGGRFARSRPGSVSNPVHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVP----- A5PKT0_DANRE A5PKT0_DANRE --E------------------IHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVP----- B0R131_DANRE B0R131_DANRE --E------------------IHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVP----- Q5JUW8_HUMAN Q5JUW8_HUMAN --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- DLG3_HUMAN DLG3_HUMAN --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- Q59FY1_HUMAN Q59FY1_HUMAN --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- DLG3_RAT DLG3_RAT --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- Q80TH1_MOUSE Q80TH1_MOUSE --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- Q52KF7_MOUSE Q52KF7_MOUSE --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- A2BEF1_MOUSE A2BEF1_MOUSE --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- DLG3_MOUSE DLG3_MOUSE --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- A2BEE9_MOUSE A2BEE9_MOUSE --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- A2BEF2_MOUSE A2BEF2_MOUSE --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- B4E0H1_HUMAN B4E0H1_HUMAN --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- Q5JUW6_HUMAN Q5JUW6_HUMAN --E------------------IHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP----- Q4SWH8_TETNG Q4SWH8_TETNG --E------------------VNYTRPVIVLGPMKDRVNDDLISEFPDKFGSCVP----- Q4T7S4_TETNG Q4T7S4_TETNG --E------------------VSYTRPVIVLGPMKDRVNDDLISEFPDKFGSCVP----- DLG1_DANRE DLG1_DANRE --E------------------VSYSRPVIILGPMKDRINDDLISEFPDKFGSCVP----- A2BHX2_DANRE A2BHX2_DANRE --E------------------VNYSRPVIILGPMKDRVNDDLISEFPDKFGSCVP----- DLG1L_DANRE DLG1L_DANRE --E------------------VNYSRPVIILGPMKDRVNDDLISEFPDKFGSCVP----- DLG1_RAT DLG1_RAT --E------------------VNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVP----- Q571K0_MOUSE Q571K0_MOUSE --------------------------------PVKD------------------------ B9EIQ5_HUMAN B9EIQ5_HUMAN --E------------------VNYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- B4DF78_HUMAN B4DF78_HUMAN --E------------------VNYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- B4DGZ8_HUMAN B4DGZ8_HUMAN --E------------------VNYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- DLG1_HUMAN DLG1_HUMAN --E------------------VNYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- B4DGU1_HUMAN B4DGU1_HUMAN --E------------------VNYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- Q59FC4_HUMAN Q59FC4_HUMAN --E------------------VNYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- Q8N3T5_HUMAN Q8N3T5_HUMAN --E------------------VNYTRPVIILGPMKDRINDDLISEFPDKFGSCVP----- Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE --E------------------VNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVP----- Q3UP61_MOUSE Q3UP61_MOUSE --E------------------VNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVP----- MATCH CONSENSUS ??E????????????????????Y?RP?IILGP?KDR?NDDL?SEFP?KFGSCVP?????

DLG4_DANRE DLG4_DANRE ---HTTRPKREYEMDGRDYHFVSSREQMEKDIQSHRFIEAGQYNSHLYGTSVQSVRQVAE Q4SFK1_TETNG Q4SFK1_TETNG ---HTTRPKREYEVDGRDYHFVSSREQMEKDIQSHRFIEAGQYNSHLYGTSVQSVREVAE A4IHB8_XENTR A4IHB8_XENTR ---HTTRPKRDYEVDGRDYHFVSSREKMEKDIQSHKFIEAGQYNGHLYGTSVQSVREVAE A9JRI4_XENTR A9JRI4_XENTR ---HTTRPKRDYEVDGRDYHFVSSREKMEKDIQSHKFIEAGQYNGHLYGTSVQSVREVAE Q0IHR6_XENTR Q0IHR6_XENTR ---HTTRPKRDYEVDGRDYHFVSSREKMEKDIQSHKFIEAGQYNGHLYGTSVQSVREVAE B7Z3U2_HUMAN B7Z3U2_HUMAN ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE B7Z4H2_HUMAN B7Z4H2_HUMAN ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE DLG4_MOUSE DLG4_MOUSE ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE DLG4_RAT DLG4_RAT ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE B7Z647_HUMAN B7Z647_HUMAN ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE B9EGL1_HUMAN B9EGL1_HUMAN ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE DLG4_HUMAN DLG4_HUMAN ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE Q3ZCU5_HUMAN Q3ZCU5_HUMAN ---HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAE Q4SLA0_TETNG Q4SLA0_TETNG ---HTTRPKRDYEVDGRDYHFVMSREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKYVAE A2BGZ1_DANRE A2BGZ1_DANRE DQEDTTRPKRDYEVDGRDYHFMASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKYVAE DLG2_DANRE DLG2_DANRE DQEDTTRPKRDYEVDGRDYHFMASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKYVAE Q5H9Q4_HUMAN Q5H9Q4_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE B7Z646_HUMAN B7Z646_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE B7Z2T4_HUMAN B7Z2T4_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE B7Z640_HUMAN B7Z640_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE B7Z264_HUMAN B7Z264_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE DLG2_MOUSE DLG2_MOUSE ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE DLG2_RAT DLG2_RAT ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE B7Z395_HUMAN B7Z395_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE A8MVF1_HUMAN A8MVF1_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE DLG2_HUMAN DLG2_HUMAN ---HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE Q4RP82_TETNG Q4RP82_TETNG ---HTTRPRRENEIDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSVLSVRTVAE A5PKT0_DANRE A5PKT0_DANRE ---HTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAE B0R131_DANRE B0R131_DANRE ---HTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAE Q5JUW8_HUMAN Q5JUW8_HUMAN ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE DLG3_HUMAN DLG3_HUMAN ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE Q59FY1_HUMAN Q59FY1_HUMAN ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE DLG3_RAT DLG3_RAT ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE Q80TH1_MOUSE Q80TH1_MOUSE ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE Q52KF7_MOUSE Q52KF7_MOUSE ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE A2BEF1_MOUSE A2BEF1_MOUSE ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE DLG3_MOUSE DLG3_MOUSE ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE A2BEE9_MOUSE A2BEE9_MOUSE ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE A2BEF2_MOUSE A2BEF2_MOUSE ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE B4E0H1_HUMAN B4E0H1_HUMAN ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE Q5JUW6_HUMAN Q5JUW6_HUMAN ---HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE Q4SWH8_TETNG Q4SWH8_TETNG ---HTTRPRRDYEVDGRDYHFVSSREVMEGEIQEHKFIEAGQYNNHLYGTSIQSVKEVAD Q4T7S4_TETNG Q4T7S4_TETNG ---HTTRPKRDYEVDGRDYHFVVSREQMEKDIQDHHFIEAGQYNNHLYGTSVQSVREVAE DLG1_DANRE DLG1_DANRE ---HTTRPKRDYEVDGRDYHFVNSREQMEKDIQDHKFIEAGQYNNHLYGTSVQSVREVAE A2BHX2_DANRE A2BHX2_DANRE ---HTTRPKRDYEVDGRDYHFVVSREQMERDIQEHKFIEAGQYNSHLYGTSVQSVREVAE DLG1L_DANRE DLG1L_DANRE ---HTTRPKRDYEVDGRDYHFVVSREQMERDIQEHKFIEAGQYNSHLYGTSVQSVREVAE DLG1_RAT DLG1_RAT ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAE Q571K0_MOUSE Q571K0_MOUSE ------------------------------------------------------------ B9EIQ5_HUMAN B9EIQ5_HUMAN ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE B4DF78_HUMAN B4DF78_HUMAN ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE B4DGZ8_HUMAN B4DGZ8_HUMAN ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE DLG1_HUMAN DLG1_HUMAN ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE B4DGU1_HUMAN B4DGU1_HUMAN ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE Q59FC4_HUMAN Q59FC4_HUMAN ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE Q8N3T5_HUMAN Q8N3T5_HUMAN ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE Q3TPP5_MOUSE Q3TPP5_MOUSE ------------------------------------------------------------ DLG1_MOUSE DLG1_MOUSE ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAE Q3UP61_MOUSE Q3UP61_MOUSE ---HTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAE MATCH CONSENSUS ???HTTRP?R??E?DG?DYHFV?SRE?MEKDIQ??KFIEAGQ?N??LYGTS?QSVR?VAE

DLG4_DANRE DLG4_DANRE Q-----------------------QGKHCILDV--------------------------- Q4SFK1_TETNG Q4SFK1_TETNG Q-----------------------QGKHCILDV--------------------------- A4IHB8_XENTR A4IHB8_XENTR Q------------------------GKHCILDV--------------------------- A9JRI4_XENTR A9JRI4_XENTR Q------------------------GKHCILDV--------------------------- Q0IHR6_XENTR Q0IHR6_XENTR Q------------------------GKHCILDV--------------------------- B7Z3U2_HUMAN B7Z3U2_HUMAN Q----------------------------------------------------------- B7Z4H2_HUMAN B7Z4H2_HUMAN Q------------------------GKHCILDV--------------------------- DLG4_MOUSE DLG4_MOUSE Q------------------------GKHCILDV--------------------------- DLG4_RAT DLG4_RAT Q------------------------GKHCILDV--------------------------- B7Z647_HUMAN B7Z647_HUMAN Q------------------------GKHCILDV--------------------------- B9EGL1_HUMAN B9EGL1_HUMAN Q------------------------GKHCILDV--------------------------- DLG4_HUMAN DLG4_HUMAN Q------------------------GKHCILDV--------------------------- Q3ZCU5_HUMAN Q3ZCU5_HUMAN Q------------------------GKHCILDV--------------------------- Q4SLA0_TETNG Q4SLA0_TETNG R--------------------VSRSTAKCVFIIETRVRLIQVESGFGENRLSSCVPGQTL A2BGZ1_DANRE A2BGZ1_DANRE R------------------------GKHCILDV--------------------------- DLG2_DANRE DLG2_DANRE R------------------------GKHCILDV--------------------------- Q5H9Q4_HUMAN Q5H9Q4_HUMAN R------------------------GKHCILDV--------------------------- B7Z646_HUMAN B7Z646_HUMAN R------------------------GKHCILDV--------------------------- B7Z2T4_HUMAN B7Z2T4_HUMAN R------------------------GKHCILDV--------------------------- B7Z640_HUMAN B7Z640_HUMAN R------------------------GKHCILDV--------------------------- B7Z264_HUMAN B7Z264_HUMAN R------------------------GKHCILDV--------------------------- DLG2_MOUSE DLG2_MOUSE R------------------------GKHCILDV--------------------------- DLG2_RAT DLG2_RAT R------------------------GKHCILDV--------------------------- B7Z395_HUMAN B7Z395_HUMAN R------------------------GKHCILGV--------------------------- A8MVF1_HUMAN A8MVF1_HUMAN R------------------------GKHCILDV--------------------------- DLG2_HUMAN DLG2_HUMAN R------------------------GKHCILDV--------------------------- Q4RP82_TETNG Q4RP82_TETNG R------------------------GKHCILDV--------------------------- A5PKT0_DANRE A5PKT0_DANRE R------------------------GKHCILDV--------------------------- B0R131_DANRE B0R131_DANRE R------------------------GKHCILDV--------------------------- Q5JUW8_HUMAN Q5JUW8_HUMAN R------------------------GKHCILDV--------------------------- DLG3_HUMAN DLG3_HUMAN R------------------------GKHCILDV--------------------------- Q59