Alignment of the gene Family HBG107819 of HOVERGEN

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Isoforms are ON
Q4SPF3_TETNG Q4SPF3_TETNG ------------------------------------------------------------ B2RWY0_MOUSE B2RWY0_MOUSE -----------------------------------------------------------M DOC10_MOUSE DOC10_MOUSE ----------------------------------------------------------MA B3FL70_HUMAN B3FL70_HUMAN -----------------------------------------------------------M DOC10_HUMAN DOC10_HUMAN ----------------------------------------------------------MA A6NIW2_HUMAN A6NIW2_HUMAN ------------------------------------------------------------ DOC11_HUMAN DOC11_HUMAN ------------------------------------------------------------ A2AF67_MOUSE A2AF67_MOUSE ------------------------------------------------------------ DOC11_MOUSE DOC11_MOUSE ------------------------------------------------------------ Q4S0A5_TETNG Q4S0A5_TETNG NVGAFGPPLIHQREASHSPGSSQPVKLLPAASRLPLTALTLPRCGGMGCTTSTVVFDGLR B2RY79_MOUSE B2RY79_MOUSE ----------------------------------------------------MAQQQLPV B2RY08_MOUSE B2RY08_MOUSE ----------------------------------------------MGCTTSVILFKGIR DOCK9_MOUSE DOCK9_MOUSE ----------------------------------------------MGCTTSVILFKGIR B2RXS7_MOUSE B2RXS7_MOUSE ----------------------------------------------------MQAEKYRT Q7TN11_MOUSE Q7TN11_MOUSE ------------------------------------------------------------ A8MWZ5_HUMAN A8MWZ5_HUMAN ----------------------------------------------------MQADKCRT Q5REN3_PONAB Q5REN3_PONAB ---------------------------------------------------MSQPPLLPA B7ZVX0_HUMAN B7ZVX0_HUMAN ---------------------------------------------------MSQPPLLPA B9EG73_HUMAN B9EG73_HUMAN ---------------------------------------------------MSQPPLLPA DOCK9_HUMAN DOCK9_HUMAN ---------------------------------------------------MSQPPLLPA MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SPF3_TETNG Q4SPF3_TETNG -------------------------------------RMSLQQEKPKAIDPLDYEAVISK B2RWY0_MOUSE B2RWY0_MOUSE SFRGKEFWKRRRTVKRVNPEGIHK-------------AGA---EKPRLLDPLDYETVIEE DOC10_MOUSE DOC10_MOUSE GERTRRFT-RSLLRPGQAAELRHS--AASAAAVAVSSRQQQRQEKPRLLDPLDYETVIEE B3FL70_HUMAN B3FL70_HUMAN SFRGKVFK-RE---PSEFWKKRRT----VRRVNQEEIHRFSSQEKPRLLEPLDYETVIEE DOC10_HUMAN DOC10_HUMAN GERTRRFT-RSLLRPGQAAELRHS--AASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEE A6NIW2_HUMAN A6NIW2_HUMAN MAEVRKFT-KRLSKPGTAAELRQS--------VSEAVRGSVVLEKAKVVEPLDYENVIAQ DOC11_HUMAN DOC11_HUMAN MAEVRKFT-KRLSKPGTAAELRQS--------VSEAVRGSVVLEKAKVVEPLDYENVIAQ A2AF67_MOUSE A2AF67_MOUSE ------------------------------------------------------------ DOC11_MOUSE DOC11_MOUSE MAEVRKFT-KRLSKPGTAAELRQS--------VSEAVRGSVVLEKAKLVEPLDYENVITQ Q4S0A5_TETNG Q4S0A5_TETNG TALERNCSGYICKGPAEPIGPSEAERALSRRESRVLPTPRVPKVKPKVIEPLDYENVLVQ B2RY79_MOUSE B2RY79_MOUSE STETRKFT-RALSKPGTAAELRQS--------VSEVVRGSVLLAKPKLIEPLDYENVIVQ B2RY08_MOUSE B2RY08_MOUSE TVFERNCA-YMCKQPGESNALEYT--AYNWSKEDSELSIAFCLAKPKLIEPLDYENVIVQ DOCK9_MOUSE DOCK9_MOUSE TVFERNCA-YMCKQPGESNALEYT--AYNWSKEDSELSIAFCLAKPKLIEPLDYENVIVQ B2RXS7_MOUSE B2RXS7_MOUSE SGRSDKKE-LVIESPLQYKDAAQA----------DVEAESSTLAKPKLIEPLDYENVIVQ Q7TN11_MOUSE Q7TN11_MOUSE ------------------------------------------------------------ A8MWZ5_HUMAN A8MWZ5_HUMAN SSRSVKKE-LVIESPLQYKDAAQG--------EVEAESPGPVPAKPKLIEPLDYENVIVQ Q5REN3_PONAB Q5REN3_PONAB SAETRKFT-RALSKPGTAAELRQS--------VSEVVRGSVLLAKPKLIEPLDYENVIVQ B7ZVX0_HUMAN B7ZVX0_HUMAN SAETRKFT-WALSKPGTAAELRQS--------VSEVVRGSVLLAKPKLIEPLDYENVIVQ B9EG73_HUMAN B9EG73_HUMAN SAETRKFT-RALSKPGTAAELRQS--------VSEVVRGSVLLAKPKLIEPLDYENVIVQ DOCK9_HUMAN DOCK9_HUMAN SAETRKFT-RALSKPGTAAELRQS--------VSEVVRGSVLLAKPKLIEPLDYENVIVQ MATCH CONSENSUS ??????????????P?????????????????????????????K?????PLDYE?VI??

Q4SPF3_TETNG Q4SPF3_TETNG LGDELKEDPLRDLLLFPDNDFLVSAVPQESRTLKSTVPEGAELEAECLLVREACKYYNSE B2RWY0_MOUSE B2RWY0_MOUSE LEKTYRDDPLQDLLFFPSDDFSTATVSWDIRTLYSTVPEEAEHRAESLLVKEACKFYSSQ DOC10_MOUSE DOC10_MOUSE LEKTYRDDPLQDLLFFPSDDFSTATVSWDIRTLYSTVPEEAEHRAESLLVKEACKFYSSQ B3FL70_HUMAN B3FL70_HUMAN LEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQ DOC10_HUMAN DOC10_HUMAN LEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQ A6NIW2_HUMAN A6NIW2_HUMAN RKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTD DOC11_HUMAN DOC11_HUMAN RKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTD A2AF67_MOUSE A2AF67_MOUSE ------------------------------------------------------------ DOC11_MOUSE DOC11_MOUSE RKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTD Q4S0A5_TETNG Q4S0A5_TETNG RKTQILSDVLRDMLQFPLEDFEILTLRRQGRTLYPTVPENAERDAHSLFVQECIKTYKSD B2RY79_MOUSE B2RY79_MOUSE KKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSD B2RY08_MOUSE B2RY08_MOUSE KKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSD DOCK9_MOUSE DOCK9_MOUSE KKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSD B2RXS7_MOUSE B2RXS7_MOUSE KKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSD Q7TN11_MOUSE Q7TN11_MOUSE ------------------------------------------------------------ A8MWZ5_HUMAN A8MWZ5_HUMAN KKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSD Q5REN3_PONAB Q5REN3_PONAB KKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSD B7ZVX0_HUMAN B7ZVX0_HUMAN KKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSD B9EG73_HUMAN B9EG73_HUMAN KKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSD DOCK9_HUMAN DOCK9_HUMAN KKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSD MATCH CONSENSUS ???????D?L???L?FP??D??????????R???STVP??AE??A??L?V?E??K?Y???

Q4SPF3_TETNG Q4SPF3_TETNG LNVLQFKYDDYAGDYRLLPRKLPKAEKLPSHSFEIDYEDVDKDE---------------- B2RWY0_MOUSE B2RWY0_MOUSE WYVVNYKYEQYSGDIRQLPRAEHKPEKLPSHSFEVDHEDADKDE---------------- DOC10_MOUSE DOC10_MOUSE WYVVNYKYEQYSGDIRQLPRAEHKPEKLPSHSFEVDHEDADKDE---------------- B3FL70_HUMAN B3FL70_HUMAN WHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEGADKDE---------------- DOC10_HUMAN DOC10_HUMAN WHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDE---------------- A6NIW2_HUMAN A6NIW2_HUMAN WHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEID-EDCEKDE---------------- DOC11_HUMAN DOC11_HUMAN WHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEID-EDCEKDE---------------- A2AF67_MOUSE A2AF67_MOUSE ------------------------------------------------------------ DOC11_MOUSE DOC11_MOUSE WHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEID-EDCEKDE---------------- Q4S0A5_TETNG Q4S0A5_TETNG WHVVNYKYEDYSGDFRQLPNKVPRPDKLAVHVFEVD-EDVDKEERHIFCLTSRKFGFFLV B2RY79_MOUSE B2RY79_MOUSE WHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVD-EEADKDE---------------- B2RY08_MOUSE B2RY08_MOUSE WHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVD-EEADKDE---------------- DOCK9_MOUSE DOCK9_MOUSE WHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVD-EEADKDE---------------- B2RXS7_MOUSE B2RXS7_MOUSE WHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVD-EEADKDE---------------- Q7TN11_MOUSE Q7TN11_MOUSE ------------------------------------------------------------ A8MWZ5_HUMAN A8MWZ5_HUMAN WHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVD-EEVDKDE---------------- Q5REN3_PONAB Q5REN3_PONAB WHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVD-EEVDKDE---------------- B7ZVX0_HUMAN B7ZVX0_HUMAN WHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVD-EEVDKDE---------------- B9EG73_HUMAN B9EG73_HUMAN WHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVD-EEVDKDE---------------- DOCK9_HUMAN DOCK9_HUMAN WHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVD-EEVDKDE---------------- MATCH CONSENSUS W??V?YKYE??SG??R?LP???????K?P?H??E?D?E???KDE????????????????

Q4SPF3_TETNG Q4SPF3_TETNG ------------------------------------------------------------ B2RWY0_MOUSE B2RWY0_MOUSE -------------------------------------DTTSHSSSKGGGGAGGTGVFKSG DOC10_MOUSE DOC10_MOUSE -------------------------------------DTTSHSSSKGGGGAGGTGVFKSG B3FL70_HUMAN B3FL70_HUMAN -------------------------------------DTTSHSSSKGGGGAGGTGVFKSG DOC10_HUMAN DOC10_HUMAN -------------------------------------DTTSHSSSKGGGGAGGTGVFKSG A6NIW2_HUMAN A6NIW2_HUMAN -------------------------------------DSSSLCSQKG-------GVIKQG DOC11_HUMAN DOC11_HUMAN -------------------------------------DSSSLCSQKG-------GVIKQG A2AF67_MOUSE A2AF67_MOUSE ------------------------------------------------------------ DOC11_MOUSE DOC11_MOUSE -------------------------------------DSSSLCSQKG-------GVIKQG Q4S0A5_TETNG Q4S0A5_TETNG NVLLTALVKVFEAGPGHQGSRTVLFVLTITSVKISRQDTASLGSQKG-------GISKHG B2RY79_MOUSE B2RY79_MOUSE -------------------------------------DAASLGSQKG-------GITKHG B2RY08_MOUSE B2RY08_MOUSE -------------------------------------DAASLGSQKG-------GITKHG DOCK9_MOUSE DOCK9_MOUSE -------------------------------------DAASLGSQKG-------GITKHG B2RXS7_MOUSE B2RXS7_MOUSE -------------------------------------DAASLGSQKG-------GITKHG Q7TN11_MOUSE Q7TN11_MOUSE ------------------------------------------------------------ A8MWZ5_HUMAN A8MWZ5_HUMAN -------------------------------------DAASLGSQKG-------GITKHG Q5REN3_PONAB Q5REN3_PONAB -------------------------------------DAASLGSQKG-------GITKHG B7ZVX0_HUMAN B7ZVX0_HUMAN -------------------------------------DAASLGSQKG-------GITKHG B9EG73_HUMAN B9EG73_HUMAN -------------------------------------DAASLGSQKG-------GITKHG DOCK9_HUMAN DOCK9_HUMAN -------------------------------------DAASLGSQKG-------GITKHG MATCH CONSENSUS ?????????????????????????????????????D??S??S?KG???????G??K?G

Q4SPF3_TETNG Q4SPF3_TETNG ------------------SFKRRYFQLTQLPDNSYIMNFYRDEKISKEPKGCIFLDSCTG B2RWY0_MOUSE B2RWY0_MOUSE WLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTG DOC10_MOUSE DOC10_MOUSE WLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTG B3FL70_HUMAN B3FL70_HUMAN WLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTG DOC10_HUMAN DOC10_HUMAN WLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTG A6NIW2_HUMAN A6NIW2_HUMAN WLHKANVNSTI--TVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACID DOC11_HUMAN DOC11_HUMAN WLHKANVNSTI--TVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACID A2AF67_MOUSE A2AF67_MOUSE ----------------MKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACID DOC11_MOUSE DOC11_MOUSE WLHKANVNSTI--TVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACID Q4S0A5_TETNG Q4S0A5_TETNG WLCKGNMNSAI--SVTMRSFKRRYFHLTQLGDGSYNLNFYKDEKISKEPKGTIFLDSCMG B2RY79_MOUSE B2RY79_MOUSE WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG B2RY08_MOUSE B2RY08_MOUSE WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG DOCK9_MOUSE DOCK9_MOUSE WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG B2RXS7_MOUSE B2RXS7_MOUSE WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG Q7TN11_MOUSE Q7TN11_MOUSE -------------------HASGFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG A8MWZ5_HUMAN A8MWZ5_HUMAN WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG Q5REN3_PONAB Q5REN3_PONAB WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG B7ZVX0_HUMAN B7ZVX0_HUMAN WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG B9EG73_HUMAN B9EG73_HUMAN WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG DOCK9_HUMAN DOCK9_HUMAN WLYKGNMNSAI--SVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMG MATCH . :* * ** *.** :* *:*** ***.** *:**:* . CONSENSUS WL?K?N?NS?????VT???FK?R?F?L?QL?D?SY??NFYKDEKISKEPKG?IFLDSC?G

Q4SPF3_TETNG Q4SPF3_TETNG VVQNNRLRKHAFELKMNEVTYFVLAAESEQDMEDWIGTLTRILQISPHDGPAPDRKSLDL B2RWY0_MOUSE B2RWY0_MOUSE VVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISP-EGPLQGRKSAEL DOC10_MOUSE DOC10_MOUSE VVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISP-EGPLQGRKSAEL B3FL70_HUMAN B3FL70_HUMAN VVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQINP-EGPLQGRRSTEL DOC10_HUMAN DOC10_HUMAN VVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISP-EGPLQGRRSTEL A6NIW2_HUMAN A6NIW2_HUMAN VVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINT-DSLVQEKKETVE DOC11_HUMAN DOC11_HUMAN VVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINT-DSLVQEKKETVE A2AF67_MOUSE A2AF67_MOUSE VVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINT-DSLVQEKKDTVE DOC11_MOUSE DOC11_MOUSE VVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINT-DSLVQEKKDTVE Q4S0A5_TETNG Q4S0A5_TETNG VVQNNKVRRFAFELKMQDKSTYLLAADSEAEMEDWINTLNKILHSGF-EIAMQEKRNGDV B2RY79_MOUSE B2RY79_MOUSE VIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNF-EAAMQEKRNGDP B2RY08_MOUSE B2RY08_MOUSE VIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNF-EAAMQEKRNGDP DOCK9_MOUSE DOCK9_MOUSE VIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNF-EAAMQEKRNGDP B2RXS7_MOUSE B2RXS7_MOUSE VIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNF-EAAMQEKRNGDP Q7TN11_MOUSE Q7TN11_MOUSE VIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNF-EAAMQEKRNGDP A8MWZ5_HUMAN A8MWZ5_HUMAN VVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNF-EAAMQEKRNGDS Q5REN3_PONAB Q5REN3_PONAB VVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWTTILNKILQLNF-EAAMQEKRNGDS B7ZVX0_HUMAN B7ZVX0_HUMAN VVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNF-EAAMQEKRNGDS B9EG73_HUMAN B9EG73_HUMAN VVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNF-EAAMQEKRNGDS DOCK9_HUMAN DOCK9_HUMAN VVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNF-EAAMQEKRNGDS MATCH *:* ::*:.****** : . ***::* :*::* *.:*:: . : ::. CONSENSUS V?QNN??R??AFELKM?D?????LAA??E??MEEW???L??ILQ????????Q???????

Q4SPF3_TETNG Q4SPF3_TETNG TDHRQDVFDLSLGDSCLQENE--DAENGINPELAKYISETDERIRSARREERLNLFSLDP B2RWY0_MOUSE B2RWY0_MOUSE AELGLDPLDNCVTCECTLEET-DSSENSLHPDFAKYLTETEDTVKTTRNMDRLNLFSLDP DOC10_MOUSE DOC10_MOUSE AELGLDPLDNCVTCECTLEET-DSSENSLHPDFAKYLTETEDTVKTTRNMGRLNLFSLDP B3FL70_HUMAN B3FL70_HUMAN TDLGLDSLDNSVTCECTPEET-DSSENNLHADFAKYLTETEDTVKTTRNMERLNLFSLDP DOC10_HUMAN DOC10_HUMAN TDLGLDSLDNSVTCECTPEET-DSSENNLHADFAKYLTETEDTVKTTRNMERLNLFSLDP A6NIW2_HUMAN A6NIW2_HUMAN TA-----QDDETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDS DOC11_HUMAN DOC11_HUMAN TA-----QDDETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDS A2AF67_MOUSE A2AF67_MOUSE AI-----QEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDS DOC11_MOUSE DOC11_MOUSE AI-----QEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDS Q4S0A5_TETNG Q4S0A5_TETNG HD-----DDDLGKSDSSSGSM-----DSF-----QSSRDIE--SRM-RSETRLKLFTLDP B2RY79_MOUSE B2RY79_MOUSE HE-----DDEQSKLEGSGSGL-----DSYLPELAKSTREAE--IKL-KSESRVKLFYLDP B2RY08_MOUSE B2RY08_MOUSE HE-----DDEQSKLEGSGSGL-----DSYLPELAKSTREAE--IKL-KSESRVKLFYLDP DOCK9_MOUSE DOCK9_MOUSE HE-----DDEQSKLEGSGSGL-----DSYLPELAKSTREAE--IKL-KSESRVKLFYLDP B2RXS7_MOUSE B2RXS7_MOUSE HE-----DDEQSKLEGSGSGL-----DSYLPELAKSTREAE--IKL-KSESRVKLFYLDP Q7TN11_MOUSE Q7TN11_MOUSE HE-----DDEQSKLEGSGSGL-----DSYLPELAKSTREAE--IKL-KSESRVKLFYLDP A8MWZ5_HUMAN A8MWZ5_HUMAN HE-----DDEQSKLEGSGSGL-----DSYLPELAKSAREAE--IKL-KSESRVKLFYLDP Q5REN3_PONAB Q5REN3_PONAB HE-----DDEQSKLEGSGSGL-----DSYLPELAKSAREAE--IKL-KSESRVKLFYLDP B7ZVX0_HUMAN B7ZVX0_HUMAN HE-----DDEQSKLEGSGSGL-----DSYLPELAKSAREAE--IKL-KSESRVKLFYLDP B9EG73_HUMAN B9EG73_HUMAN HE-----DDEQSKLEGSGSGL-----DSYLPELAKSAREAE--IKL-KSESRVKLFYLDP DOCK9_HUMAN DOCK9_HUMAN HE-----DDEQSKLEGSGSGL-----DSYLPELAKSAREAE--IKL-KSESRVKLFYLDP MATCH : . . : : : : : * :** :*. CONSENSUS ????????D??????????????????S??P???K???E?E???K??????R??LF?LDP

Q4SPF3_TETNG Q4SPF3_TETNG DTPVSKGHSTPLQQLPSSLYPCHQPQVLRSPRAEHSSVENGAVRPFEEKLGRRFMVTCRS B2RWY0_MOUSE B2RWY0_MOUSE DI----------DTLKLQKRDSFENELM--------------IKPFEEKAAKRIMIICRA DOC10_MOUSE DOC10_MOUSE DI----------DTLKLQKRDSFENELM--------------IKPFEEKAAKRIMIICRA B3FL70_HUMAN B3FL70_HUMAN DI----------DTLKLQKKDLLEPESV--------------IKPFEEKAAKRIMIICKA DOC10_HUMAN DOC10_HUMAN DI----------DTLKLQKKDLLEPESV--------------IKPFEEKAAKRIMIICKA A6NIW2_HUMAN A6NIW2_HUMAN EV----------QRLDFS---GIEPD----------------IKPFEEKCNKRFLVNCHD DOC11_HUMAN DOC11_HUMAN EV----------QRLDFS---GIEPD----------------IKPFEEKCNKRFLVNCHD A2AF67_MOUSE A2AF67_MOUSE EV----------QRLDFS---GIEPD----------------VKPFEEKCNKRFMVNCHD DOC11_MOUSE DOC11_MOUSE EV----------QRLDFS---GIEPD----------------VKPFEEKCNKRFMVNCHD Q4S0A5_TETNG Q4S0A5_TETNG DT----------QRLDFS---GIEPD----------------VKQFEEKFGKRVLVNCND B2RY79_MOUSE B2RY79_MOUSE DT----------QKLDFS---SAEPE----------------VKPFEEKFGKRILVKCND B2RY08_MOUSE B2RY08_MOUSE DT----------QKLDFS---SAEPE----------------VKPFEEKFGKRILVKCND DOCK9_MOUSE DOCK9_MOUSE DT----------QKLDFS---SAEPE----------------VKPFEEKFGKRILVKCND B2RXS7_MOUSE B2RXS7_MOUSE DT----------QKLDFS---SAEPE----------------VKPFEEKFGKRILVKCND Q7TN11_MOUSE Q7TN11_MOUSE DT----------QKLDFS---SAEPE----------------VKPFEEKFGKRILVKCND A8MWZ5_HUMAN A8MWZ5_HUMAN DA----------QKLDFS---SAEPE----------------VKSFEEKFGKRILVKCND Q5REN3_PONAB Q5REN3_PONAB DA----------QKLDFS---SAEPE----------------VKPFEEKFGKRILVKCND B7ZVX0_HUMAN B7ZVX0_HUMAN DA----------QKLDFS---SAEPE----------------VKSFEEKFGKRILVKCND B9EG73_HUMAN B9EG73_HUMAN DA----------QKLDFS---SAEPE----------------VKSFEEKFGKRILVKCND DOCK9_HUMAN DOCK9_HUMAN DA----------QKLDFS---SAEPE----------------VKSFEEKFGKRILVKCND MATCH : : * . : : :: **** :*.:: *. CONSENSUS D???????????Q?L??S?????EP??????????????????K?FEEK??KR??V?C??

Q4SPF3_TETNG Q4SPF3_TETNG LNLMLQGCISESETGPVTNIEPFFVSLALLDVREGRKVSADFHVDLNHEAVRQMLGSCSN B2RWY0_MOUSE B2RWY0_MOUSE LNFNLQGCVTENEYDPVTNIEPFFVSVALYDLRDNRKISADFHVDLNHPAVRQMLSGTPP DOC10_MOUSE DOC10_MOUSE LNFNLQGCVTENEYDPVTNIEPFFVSVALYDLRDNRKISADFHVDLNHPAVRQMLSGTPP B3FL70_HUMAN B3FL70_HUMAN LNSNLQGCVTENENDPITNIEPLFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASV DOC10_HUMAN DOC10_HUMAN LNSNLQGCVTENENDPITNIEPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASV A6NIW2_HUMAN A6NIW2_HUMAN LTFNILGQIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSST DOC11_HUMAN DOC11_HUMAN LTFNILGQIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSST A2AF67_MOUSE A2AF67_MOUSE LTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTST DOC11_MOUSE DOC11_MOUSE LTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTST Q4S0A5_TETNG Q4S0A5_TETNG LAFNLQSCVAENEEGPTTNVEPFYVTLSLFDIQNGRKISSDFHVDLNHPSVRAMVPSFSS B2RY79_MOUSE B2RY79_MOUSE LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPTSP B2RY08_MOUSE B2RY08_MOUSE LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPTSP DOCK9_MOUSE DOCK9_MOUSE LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPTSP B2RXS7_MOUSE B2RXS7_MOUSE LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPTSP Q7TN11_MOUSE Q7TN11_MOUSE LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTPTSP A8MWZ5_HUMAN A8MWZ5_HUMAN LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSP Q5REN3_PONAB Q5REN3_PONAB LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTTTSL B7ZVX0_HUMAN B7ZVX0_HUMAN LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSP B9EG73_HUMAN B9EG73_HUMAN LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSP DOCK9_HUMAN DOCK9_HUMAN LSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSP MATCH * : : :. .* **:**:::.::* *:: . *:*:******* :** *: . CONSENSUS L?FNLQ?C??ENE?GP?TN?EPFFV?L?L?D???NRKISADFHVDLNH??VR?ML???S?

Q4SPF3_TETNG Q4SPF3_TETNG GTTGPGAGVGVGVGV---QENGLCSPAEKKPGDCSLSVDTEHWLCFPKQAIFSVTNPHTD B2RWY0_MOUSE B2RWY0_MOUSE ALENGNIDTGTPRQSEEPHIKGL----------------PEEWLKFPKQAVFSVSDPHSE DOC10_MOUSE DOC10_MOUSE ALENGNIDTGTPRQSEEPHIKGL----------------PEEWLKFPKQAVFSVSDPHSE B3FL70_HUMAN B3FL70_HUMAN ALENGNIDTITPRQSEEPHIKGL----------------PEEWLKFPKQAVFSVSNPHSE DOC10_HUMAN DOC10_HUMAN ALENGNIDTITPRQSEEPHIKGL----------------PEEWLKFPKQAVFSVSNPHSE A6NIW2_HUMAN A6NIW2_HUMAN QLASDGSPKGSSPES---YIHGI----------------AESQLRYIQQGIFSVTNPHPE DOC11_HUMAN DOC11_HUMAN QLASDGSPKGSSPES---YIHGI----------------AESQLRYIQQGIFSVTNPHPE A2AF67_MOUSE A2AF67_MOUSE QLSNDGNAKGFSPES---LIHGI----------------AESQLCYIKQGIFSVTNPHPE DOC11_MOUSE DOC11_MOUSE QLSNDGNAKGFSPES---LIHGI----------------AESQLCYIKQGIFSVTNPHPE Q4S0A5_TETNG Q4S0A5_TETNG QYINGG---GDTHPEGPRFVHGV----------------PEAVLRYPRQAMFSVTCPHPD B2RY79_MOUSE B2RY79_MOUSE ALMNG----GQSPPA---FQDAL----------------H-TAMQYPKQGIFSVTCPHPD B2RY08_MOUSE B2RY08_MOUSE ALMNG----GQSPPA---FQDAL----------------H-TAMQYPKQGIFSVTCPHPD DOCK9_MOUSE DOCK9_MOUSE ALMNG----GQSPPA---FQDAL----------------H-TAMQYPKQGIFSVTCPHPD B2RXS7_MOUSE B2RXS7_MOUSE ALMNG----GQSPPA---FQDAL----------------H-TAMQYPKQGIFSVTCPHPD Q7TN11_MOUSE Q7TN11_MOUSE ALMNG----GQSPPA---FQDAL----------------H-TAMQYPKQGIFSVTCPHPD A8MWZ5_HUMAN A8MWZ5_HUMAN ALMNGS---GQSPSV---LKGIL----------------HEAAMQYPKQGIFSVTCPHPD Q5REN3_PONAB Q5REN3_PONAB ALMNGS---GQSPSV---LKGIL----------------HEAAMQYPKQGIFSVTCPHPD B7ZVX0_HUMAN B7ZVX0_HUMAN ALMNGS---GQSPSV---LKGIL----------------HEAAMQYPKQGIFSVTCPHPD B9EG73_HUMAN B9EG73_HUMAN ALMNGS---GQSPSV---LKGIL----------------HEAAMQYPKQGIFSVTCPHPD DOCK9_HUMAN DOCK9_HUMAN ALMNGS---GQSPSV---LKGIL----------------HEAAMQYPKQGIFSVTCPHPD MATCH . : : : :*.:***: **.: CONSENSUS ?L?N?????G????????????????????????????????????PKQ??FSVT?PH??

Q4SPF3_TETNG Q4SPF3_TETNG IVMVARVEKVLMGNIACGTEPYIKNTDSSKTVQKIVKSNKHFCSKLGQYRMPFAWSVRSV B2RWY0_MOUSE B2RWY0_MOUSE IVLVAKVEKVLMGNIGSGAEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWAV--- DOC10_MOUSE DOC10_MOUSE IVLVAKVEKVLMGNIGSGAEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWAV--- B3FL70_HUMAN B3FL70_HUMAN IVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAV--- DOC10_HUMAN DOC10_HUMAN IVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAV--- A6NIW2_HUMAN A6NIW2_HUMAN IFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQKVHRTAKQVCSRLGQYRMPFAWAA--- DOC11_HUMAN DOC11_HUMAN IFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQKVHRTAKQVCSRLGQYRMPFAWAA--- A2AF67_MOUSE A2AF67_MOUSE IFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAA--- DOC11_MOUSE DOC11_MOUSE IFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAA--- Q4S0A5_TETNG Q4S0A5_TETNG IFLVARIEKVLQGGINHCAEPYMKSSDSTKVAQKVLKNAKWACCRLGQYRMPFAWAA--- B2RY79_MOUSE B2RY79_MOUSE IFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- B2RY08_MOUSE B2RY08_MOUSE IFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- DOCK9_MOUSE DOCK9_MOUSE IFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- B2RXS7_MOUSE B2RXS7_MOUSE IFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- Q7TN11_MOUSE Q7TN11_MOUSE IFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- A8MWZ5_HUMAN A8MWZ5_HUMAN IFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- Q5REN3_PONAB Q5REN3_PONAB IFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- B7ZVX0_HUMAN B7ZVX0_HUMAN IFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- B9EG73_HUMAN B9EG73_HUMAN IFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- DOCK9_HUMAN DOCK9_HUMAN IFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAA--- MATCH *.:*.::**** *.* :***::..*. * .**: :. : * :**:*******:. CONSENSUS I?LVARIEKVL?G?I???AEPY????DS?K?AQK??K??KQ?C??LGQYRMPFAWA????

Q4SPF3_TETNG Q4SPF3_TETNG VGGSVSLTVLMRCCIYADPLSPYRSVFRDNHGALDRESRFSPLFKQESNKISVDDLVKLV B2RWY0_MOUSE B2RWY0_MOUSE -----------------------RSVFKDNQGNVDRDSRFSPLYRQESSKMSSEDLLKLV DOC10_MOUSE DOC10_MOUSE -----------------------RSVFKDNQGNVDRDSRFSPLYRQESSKMSSEDLLKLV B3FL70_HUMAN B3FL70_HUMAN -----------------------RSVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLV DOC10_HUMAN DOC10_HUMAN -----------------------RYVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLV A6NIW2_HUMAN A6NIW2_HUMAN -----------------------RPIFKDTQGSLDLDGRFSPLYKQDSSKLSSEDILKLL DOC11_HUMAN DOC11_HUMAN -----------------------RPIFKDTQGSLDLDGRFSPLYKQDSSKLSSEDILKLL A2AF67_MOUSE A2AF67_MOUSE -----------------------RPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLL DOC11_MOUSE DOC11_MOUSE -----------------------RPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLL Q4S0A5_TETNG Q4S0A5_TETNG -----------------------RPLFRDASGTLDKSARFSPLYRQDSNKLSNEDMLRLL B2RY79_MOUSE B2RY79_MOUSE -----------------------RTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLL B2RY08_MOUSE B2RY08_MOUSE -----------------------RTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLL DOCK9_MOUSE DOCK9_MOUSE -----------------------RTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLL B2RXS7_MOUSE B2RXS7_MOUSE -----------------------RTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLL Q7TN11_MOUSE Q7TN11_MOUSE -----------------------RTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLL A8MWZ5_HUMAN A8MWZ5_HUMAN -----------------------RTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLL Q5REN3_PONAB Q5REN3_PONAB -----------------------RTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLL B7ZVX0_HUMAN B7ZVX0_HUMAN -----------------------RTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLL B9EG73_HUMAN B9EG73_HUMAN -----------------------RTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLL DOCK9_HUMAN DOCK9_HUMAN -----------------------RTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLL MATCH * :*:* * :* ..***.:::*:*.*:* :*:::*: CONSENSUS ???????????????????????R??FKD??G?LD???RFS??Y?Q?S?K?S??D?LKL?

Q4SPF3_TETNG Q4SPF3_TETNG SEYRRAEKTSKLQTIPGTLDIAFDYVPMEHPSASDLHSVCARLCCLPVMVFHTVSTPPDC B2RWY0_MOUSE B2RWY0_MOUSE SDYRRADRISKMQSIPGSLDIAVDNIPLEHPN---------------------------C DOC10_MOUSE DOC10_MOUSE SDYRRADRISKMQSIPGSLDIAVDNIPLEHPN---------------------------C B3FL70_HUMAN B3FL70_HUMAN SDYRRADRISKMQTIPGSLDIAVDNVPLEHPN---------------------------C DOC10_HUMAN DOC10_HUMAN SDYRRADRISKMQTIPGSLDIAVDNVPLEHPD---------------------------C A6NIW2_HUMAN A6NIW2_HUMAN SEYKKPEK-TKLQIIPGQLNITVECVPVDLSN---------------------------C DOC11_HUMAN DOC11_HUMAN SEYKKPEK-TKLQIIPGQLNITVECVPVDLSN---------------------------C A2AF67_MOUSE A2AF67_MOUSE SEYKKPEK-TKLQIIPGQLSITVECVPVDLPN---------------------------C DOC11_MOUSE DOC11_MOUSE SEYKKPEK-TKLQIIPGQLSITVECVPVDLPN---------------------------C Q4S0A5_TETNG Q4S0A5_TETNG ADFRKPEKMAKLPVILGNLDVTIDNVAPDLTN---------------------------C B2RY79_MOUSE B2RY79_MOUSE ADFRKPEKMAKLPVILGNLDITIDSVSCDFPN---------------------------Y B2RY08_MOUSE B2RY08_MOUSE ADFRKPEKMAKLPVILGNLDITIDSVSCDFPN---------------------------Y DOCK9_MOUSE DOCK9_MOUSE ADFRKPEKMAKLPVILGNLDITIDSVSCDFPN---------------------------Y B2RXS7_MOUSE B2RXS7_MOUSE ADFRKPEKMAKLPVILGNLDITIDSVSCDFPN---------------------------Y Q7TN11_MOUSE Q7TN11_MOUSE ADFRKPEKMAKLPVILGNLDITIDSVSCDFPN---------------------------Y A8MWZ5_HUMAN A8MWZ5_HUMAN ADFRKPEKMAKLPVILGNLDITIDNVSSDFPN---------------------------Y Q5REN3_PONAB Q5REN3_PONAB ADFRKPEKMAKLPVILGNLDITIDNVSSDFPN---------------------------Y B7ZVX0_HUMAN B7ZVX0_HUMAN ADFRKPEKMAKLPVILGNLDITIDNVSSDFPN---------------------------Y B9EG73_HUMAN B9EG73_HUMAN ADFRKPEKMAKLPVILGNLDITIDNVSSDFPN---------------------------Y DOCK9_HUMAN DOCK9_HUMAN ADFRKPEKMAKLPVILGNLDITIDNVSSDFPN---------------------------Y MATCH :::::.:: :*: * * *.::.: :. : .. CONSENSUS ???R??EK??KL??I?G?LDI??D?V????PN????????????????????????????

Q4SPF3_TETNG Q4SPF3_TETNG VTSSYVPVRPFEELSKHQPTVEVEEFVQDSTKFTLPHRVYRNHIYVYPKHLKYDSQKSFA B2RWY0_MOUSE B2RWY0_MOUSE VTSSFIPVKPFNVTAQSEPTVEVEEFIYDSTKYCRPYRVYKNQIYVYPKHLKYDSQKCFN DOC10_MOUSE DOC10_MOUSE VTSSFIPVKPFNVSAQSEPTVEVEEFIYDSTKYCRPYRVYKNQIYVYPKHLKYDSQKCFN B3FL70_HUMAN B3FL70_HUMAN VTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFN DOC10_HUMAN DOC10_HUMAN VTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFN A6NIW2_HUMAN A6NIW2_HUMAN ITSSYVPLKPFEKNCQN-ITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFA DOC11_HUMAN DOC11_HUMAN ITSSYVPLKPFEKNCQN-ITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFA A2AF67_MOUSE A2AF67_MOUSE ITSSYVPLKPFEKNCQN-ITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFA DOC11_MOUSE DOC11_MOUSE ITSSYVPLKPFEKNCQN-ITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFA Q4S0A5_TETNG Q4S0A5_TETNG VTSSYIPVKQFDVGEKANVFFEVEEFVPCIAKCSQPFTIYNNHLYVYPKHLKYDSQKSFA B2RY79_MOUSE B2RY79_MOUSE LNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFA B2RY08_MOUSE B2RY08_MOUSE LNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFA DOCK9_MOUSE DOCK9_MOUSE LNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFA B2RXS7_MOUSE B2RXS7_MOUSE LNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFA Q7TN11_MOUSE Q7TN11_MOUSE LNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFA A8MWZ5_HUMAN A8MWZ5_HUMAN VNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFA Q5REN3_PONAB Q5REN3_PONAB VNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFA B7ZVX0_HUMAN B7ZVX0_HUMAN VNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFA B9EG73_HUMAN B9EG73_HUMAN VNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFA DOCK9_HUMAN DOCK9_HUMAN VNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFA MATCH :.**::* : *: : .*****: .* *. :* *::*:** ******* * CONSENSUS ??SSY?P???F????????T?EVEEFV????K???P???Y?NH?YVYPK?LKYDSQK?FA

Q4SPF3_TETNG Q4SPF3_TETNG KARNLAVYVEFRSSDDEVAKPLKCIYGKPGGPVFTTAACSTVLHHSQNPDFYDEVKIELP B2RWY0_MOUSE B2RWY0_MOUSE KARNITVCIEFKNSDDDGAKPMKCIYGKPGGPLFTSSAYTAVLHHSQNPDFSDEVKIELP DOC10_MOUSE DOC10_MOUSE KARNITVCIEFKNSDDDGAKPMKCIYGKPGGPLFTSSAYTAVLHHSQNPDFSDEVKIELP B3FL70_HUMAN B3FL70_HUMAN KARNTTVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELP DOC10_HUMAN DOC10_HUMAN KARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELP A6NIW2_HUMAN A6NIW2_HUMAN KARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELP DOC11_HUMAN DOC11_HUMAN KARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELP A2AF67_MOUSE A2AF67_MOUSE KARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELP DOC11_MOUSE DOC11_MOUSE KARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELP Q4S0A5_TETNG Q4S0A5_TETNG KARNIAVCIEFRDSDEEDAVSLKCIYGRPGGPLFTKNAFAAVLHHQQNPEFYDEYKIELP B2RY79_MOUSE B2RY79_MOUSE KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELP B2RY08_MOUSE B2RY08_MOUSE KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELP DOCK9_MOUSE DOCK9_MOUSE KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELP B2RXS7_MOUSE B2RXS7_MOUSE KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELP Q7TN11_MOUSE Q7TN11_MOUSE KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELP A8MWZ5_HUMAN A8MWZ5_HUMAN KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELP Q5REN3_PONAB Q5REN3_PONAB KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELP B7ZVX0_HUMAN B7ZVX0_HUMAN KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELP B9EG73_HUMAN B9EG73_HUMAN KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELP DOCK9_HUMAN DOCK9_HUMAN KARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELP MATCH **** :: :**:.**:. : .:*****:*.*.:** * :.* ** ***:* ** ***** CONSENSUS KARNIA?C?EF??SDE?????LKCIYG?PGGP?FT??A???VLHH?QNP?FYDE?KIELP

Q4SPF3_TETNG Q4SPF3_TETNG TQLHDKHHLLFSFYHVTCDINAKTNAKRKESLETPGESVGKPAAAWCQKEFLCKGSFLCG B2RWY0_MOUSE B2RWY0_MOUSE TQLHGKHHLLFSFYHITCDINAKANAKKKEALETS------------------------- DOC10_MOUSE DOC10_MOUSE TQLHGKHHLLFSFYHITCDINAKANAKKKEALETS------------------------- B3FL70_HUMAN B3FL70_HUMAN TQLHEKHHILFSFYHVTCDINAKANAKKKEALETS------------------------- DOC10_HUMAN DOC10_HUMAN TQLHEKHHILFSFYHVTCDINAKANAKKKEALETS------------------------- A6NIW2_HUMAN A6NIW2_HUMAN IHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETP------------------------- DOC11_HUMAN DOC11_HUMAN IHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETP------------------------- A2AF67_MOUSE A2AF67_MOUSE IHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETP------------------------- DOC11_MOUSE DOC11_MOUSE IHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETP------------------------- Q4S0A5_TETNG Q4S0A5_TETNG TQLHEKHHLLFTFYHVSCDSNSKASTKKRDLIETQ------------------------- B2RY79_MOUSE B2RY79_MOUSE AQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQ------------------------- B2RY08_MOUSE B2RY08_MOUSE AQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQ------------------------- DOCK9_MOUSE DOCK9_MOUSE AQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQ------------------------- B2RXS7_MOUSE B2RXS7_MOUSE AQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQ------------------------- Q7TN11_MOUSE Q7TN11_MOUSE AQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQ------------------------- A8MWZ5_HUMAN A8MWZ5_HUMAN TQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQ------------------------- Q5REN3_PONAB Q5REN3_PONAB TQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQ------------------------- B7ZVX0_HUMAN B7ZVX0_HUMAN TQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQ------------------------- B9EG73_HUMAN B9EG73_HUMAN TQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQ------------------------- DOCK9_HUMAN DOCK9_HUMAN TQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQ------------------------- MATCH :** :**:*::*:*::*: .:* .:*::: :** CONSENSUS ?QLH??HHLL??F?HV?CD???K???KK????ET??????????????????????????

Q4SPF3_TETNG Q4SPF3_TETNG LLIFVVGFSWLPLFKEGRLSSQEFSIPVSCNLPPGYLAIKEASNTKN-GADVKWVDGGKA B2RWY0_MOUSE B2RWY0_MOUSE -----VGYAWLPLMKHDQIASQEYNIPIATTLPPNYLSIQDPTSAKHGGSDIKWVDGGKP DOC10_MOUSE DOC10_MOUSE -----VGYAWLPLMKHDQIASQEYNIPIATTLPPNYLSIQDPTSAKHGGSDIKWVDGGKP B3FL70_HUMAN B3FL70_HUMAN -----VGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKP DOC10_HUMAN DOC10_HUMAN -----VGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSAS--HGGSDIKWVDGGKP A6NIW2_HUMAN A6NIW2_HUMAN -----VGFAWVPLLKDGRIITFEQQLPVSANLPPGYLNLNDAESRRQCNVDIKWVDGAKP DOC11_HUMAN DOC11_HUMAN -----VGFAWVPLLKDGRIITFEQQLPVSANLPPGYLNLNDAESRRQCNVDIKWVDGAKP A2AF67_MOUSE A2AF67_MOUSE -----VGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKP DOC11_MOUSE DOC11_MOUSE -----VGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKP Q4S0A5_TETNG Q4S0A5_TETNG -----VGYAWLPLLKDGRVITNDNHIPVSTSLPAGYLSCQE-NASKHSGPEVKWVDGGKP B2RY79_MOUSE B2RY79_MOUSE -----VGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKP B2RY08_MOUSE B2RY08_MOUSE -----VGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKP DOCK9_MOUSE DOCK9_MOUSE -----VGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKP B2RXS7_MOUSE B2RXS7_MOUSE -----VGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKP Q7TN11_MOUSE Q7TN11_MOUSE -----VGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKP A8MWZ5_HUMAN A8MWZ5_HUMAN -----VGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKP Q5REN3_PONAB Q5REN3_PONAB -----VGYSWLPLLKDGRVVTSEQHIPVSVNLPSGYLGYQELGMGRHYGPEIKWVDGGKP B7ZVX0_HUMAN B7ZVX0_HUMAN -----VGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKP B9EG73_HUMAN B9EG73_HUMAN -----VGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKP DOCK9_HUMAN DOCK9_HUMAN -----VGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKP MATCH **::*:**:*..:: : : :*:: .**..** :: : . ::***:*.*. CONSENSUS ?????VG??WLPL?K?GR????E??IPVS??LP?GYL???????????G???KWV?GGKP

Q4SPF3_TETNG Q4SPF3_TETNG IFKVSTNVVSTVYTQDPHLNRFFQQCQKRELDLSLPP-TSNFLNCLKGLLSMERIPVIIR B2RWY0_MOUSE B2RWY0_MOUSE LFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSP-TSSFVRACKNLLNVDKIHSIMS DOC10_MOUSE DOC10_MOUSE LFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSP-TSSFVRACKNLLNVDKIHSIMS B3FL70_HUMAN B3FL70_HUMAN LFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSP-TSNFIRSCKNLLNVEKIHAIMS DOC10_HUMAN DOC10_HUMAN LFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSP-TSNFIRSCKNLLNVEKIHAIMS A6NIW2_HUMAN A6NIW2_HUMAN LLKIKSHLESTIYTQDLHVHKFFHHCQLIQSGSKEV--PGELIKYLKCLHAME-IQVMIQ DOC11_HUMAN DOC11_HUMAN LLKIKSHLESTIYTQDLHVHKFFHHCQLIQSGSKEV--PGELIKYLKCLHAME-IQVMIQ A2AF67_MOUSE A2AF67_MOUSE LLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEV--PGELIKYLKCLHAME-IQVMIQ DOC11_MOUSE DOC11_MOUSE LLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEV--PGELIKYLKCLHAME-IQVMIQ Q4S0A5_TETNG Q4S0A5_TETNG LFKVSTHLASTVYTQDQHLHNFFHHCQISAPAPQETRGGGELVKYLKSLHAME-SHVMIK B2RY79_MOUSE B2RY79_MOUSE LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAS--GSELVKYLKSLHAME-GHVMIA B2RY08_MOUSE B2RY08_MOUSE LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAS--GSELVKYLKSLHAME-GHVMIA DOCK9_MOUSE DOCK9_MOUSE LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAS--GSELVKYLKSLHAME-GHVMIA B2RXS7_MOUSE B2RXS7_MOUSE LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAS--GSELVKYLKSLHAME-GHVMIA Q7TN11_MOUSE Q7TN11_MOUSE LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAS--GSELVKYLKSLHAME-GHVMIA A8MWZ5_HUMAN A8MWZ5_HUMAN LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAL--GNELVKYLKSLHAME-GHVMIA Q5REN3_PONAB Q5REN3_PONAB LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAL--GNELVKYLKSLHAME-GHVMIA B7ZVX0_HUMAN B7ZVX0_HUMAN LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAL--GNELVKYLKSLHAME-GHVMIA B9EG73_HUMAN B9EG73_HUMAN LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAL--GNELVKYLKSLHAME-GHVMIA DOCK9_HUMAN DOCK9_HUMAN LLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQAL--GNELVKYLKSLHAME-GHVMIA MATCH ::*:.: : **: *** *:: **: ** . ..::. * * :: :: CONSENSUS L?K?ST???STVYTQD?H???FF??CQ??????????????????LK?L??ME???V?I?

Q4SPF3_TETNG Q4SPF3_TETNG FLPVLFNQLFKVLIQND-NDEVTTATTR-VLVHIVAKCHEENLDHYLHSYIKYVFKAEVH B2RWY0_MOUSE B2RWY0_MOUSE FLPIILNQLFKILVQNE-EDEITATVTR-VLADIVAKCHEEQLDHSVQSYIKFVFKTKSY DOC10_MOUSE DOC10_MOUSE FLPIILNQLFKILVQNE-EDEITATVTR-VLADIVAKCHEEQLDHSVQSYIKFVFKTKSY B3FL70_HUMAN B3FL70_HUMAN FLPIILNQLFKVLVQNE-EDEITTTVTR-VLTDIVAKCHEEQLDHSVQSYIKFVFKTR-- DOC10_HUMAN DOC10_HUMAN FLPIILNQLFKVLVQNE-EDEITTTVTR-VLTDIVAKCHEEQLDHSVQSYIKFVFKTR-- A6NIW2_HUMAN A6NIW2_HUMAN FLPVILMQLFRVLTNMTHEDDVPINCTM-VLLHIVSKCHEEGLDSYLRSFIKYSFRPEKP DOC11_HUMAN DOC11_HUMAN FLPVILMQLFRVLTNMTHEDDVPINCTM-VLLHIVSKCHEEGLDSYLRSFIKYSFRPEKP A2AF67_MOUSE A2AF67_MOUSE FLPVILMQLFRVLTNMTHEDDVPINCTM-VLLHIVSKCHEEGLESYLRSFIKYSFRPEKP DOC11_MOUSE DOC11_MOUSE FLPVILMQLFRVLTNMTHEDDVPINCTM-VLLHIVSKCHEEGLESYLRSFIKYSFRPEKP Q4S0A5_TETNG Q4S0A5_TETNG FLPTILNQLFRVLTSAT-QEDVAVNVTRQVMIHVVAQCHEEGLEHYLRSYVKFVFKTEPF B2RY79_MOUSE B2RY79_MOUSE FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKFAYKAEPY B2RY08_MOUSE B2RY08_MOUSE FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKFAYKAEPY DOCK9_MOUSE DOCK9_MOUSE FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKFAYKAEPY B2RXS7_MOUSE B2RXS7_MOUSE FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKFAYKAEPY Q7TN11_MOUSE Q7TN11_MOUSE FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKFAYKAEPY A8MWZ5_HUMAN A8MWZ5_HUMAN FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKYAYKAEPY Q5REN3_PONAB Q5REN3_PONAB FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKYAYKAEPY B7ZVX0_HUMAN B7ZVX0_HUMAN FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKYAYKAEPY B9EG73_HUMAN B9EG73_HUMAN FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKYAYKAEPY DOCK9_HUMAN DOCK9_HUMAN FLPTILNQLFRVLTRAT-QEEVAVNVTR-VIIHVVAQCHEEGLESHLRSYVKYAYKAEPY MATCH *** :: ***::* ::::. * *: .:*::**** *: ::*::*: ::.. CONSENSUS FLP?ILNQLF?VL????????V????TR?V??H?VA?CHEE?L???L?SY?K???K?E??

Q4SPF3_TETNG Q4SPF3_TETNG ---GFRTVHEELAKGMTFDLK-SNEHSAVRNVLKFSWFFFELIVKSMAQNLVDSDKVKLP B2RWY0_MOUSE B2RWY0_MOUSE ---KERTIHEELAKNLSDLLK-SNDSTIVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLP DOC10_MOUSE DOC10_MOUSE ---KERTIHEELAKNLSDLLK-SNDSTIVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLP B3FL70_HUMAN B3FL70_HUMAN -ACKERTVHEELAKNVTGLLK-SNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLP DOC10_HUMAN DOC10_HUMAN -ACKERTVHEELAKNVTGLLK-SNDSTTVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLP A6NIW2_HUMAN A6NIW2_HUMAN SAPQAQLIHETLATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSMATYLLEENKIKLP DOC11_HUMAN DOC11_HUMAN SAPQAQLIHETLATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSMATYLLEENKIKLP A2AF67_MOUSE A2AF67_MOUSE STLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLP DOC11_MOUSE DOC11_MOUSE STLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLP Q4S0A5_TETNG Q4S0A5_TETNG TSSTTRTVHEELAKAMTSILKPSTDFLTSNKLLKYSWYFFEALVKSMAQYLIESSKVKLS B2RY79_MOUSE B2RY79_MOUSE VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLL B2RY08_MOUSE B2RY08_MOUSE VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLL DOCK9_MOUSE DOCK9_MOUSE VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLL B2RXS7_MOUSE B2RXS7_MOUSE VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLL Q7TN11_MOUSE Q7TN11_MOUSE VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLL A8MWZ5_HUMAN A8MWZ5_HUMAN VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLL Q5REN3_PONAB Q5REN3_PONAB VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLL B7ZVX0_HUMAN B7ZVX0_HUMAN VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLL B9EG73_HUMAN B9EG73_HUMAN VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLL DOCK9_HUMAN DOCK9_HUMAN VASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLL MATCH : :** *:. : ** * : .::*:.**:** : **** *:: .*::* CONSENSUS ??????T?HEEL?K?M???LK?S?D???????LK?SWFFF????KSMAQ?L????K?KL?

Q4SPF3_TETNG Q4SPF3_TETNG RPQRFPSSYLSRLETLVETVSEHIFWKNKDLAEETRSANLGVAAFFKRCFTLMDRGFTFK B2RWY0_MOUSE B2RWY0_MOUSE RAQRFPESYQSELDNLVMGLCDHVIWKCKEAPEETKRANHSVARFLKRCFTFMDRGFVFK DOC10_MOUSE DOC10_MOUSE RAQRFPESYQSELDNLVMGLCDHVIWKCKEAPEETKRANHSVARFLKRCFTFMDRGFVFK B3FL70_HUMAN B3FL70_HUMAN RPQRFPESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFK DOC10_HUMAN DOC10_HUMAN RPQRFPESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFK A6NIW2_HUMAN A6NIW2_HUMAN RGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFN DOC11_HUMAN DOC11_HUMAN RGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFN A2AF67_MOUSE A2AF67_MOUSE RGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFN DOC11_MOUSE DOC11_MOUSE RGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFN Q4S0A5_TETNG Q4S0A5_TETNG RNQRFSASFHHTVETLVNLIMPHITQKYKDNLDAARNANHSLAVFIKRCFNLMDRGFVFK B2RY79_MOUSE B2RY79_MOUSE RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK B2RY08_MOUSE B2RY08_MOUSE RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK DOCK9_MOUSE DOCK9_MOUSE RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK B2RXS7_MOUSE B2RXS7_MOUSE RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK Q7TN11_MOUSE Q7TN11_MOUSE RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK A8MWZ5_HUMAN A8MWZ5_HUMAN RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK Q5REN3_PONAB Q5REN3_PONAB RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK B7ZVX0_HUMAN B7ZVX0_HUMAN RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK B9EG73_HUMAN B9EG73_HUMAN RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK DOCK9_HUMAN DOCK9_HUMAN RNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFK MATCH * ***. :: :..:: : *: : : : :: * .:* *:***:.:****: *: CONSENSUS R?QRFP?SY???????V?????H???K????P?????AN?S?A?F?KRCFT?MDRGFVFK

Q4SPF3_TETNG Q4SPF3_TETNG LISNYINMISTTDSKVLCELKFEFLREVCNHEHYIPLSLPL-------PSARIT------ B2RWY0_MOUSE B2RWY0_MOUSE MVNNYISMFSSGEFKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIRELH DOC10_MOUSE DOC10_MOUSE MVNNYISMFSSGEFKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIRELH B3FL70_HUMAN B3FL70_HUMAN MVNNYISIFSSGDLKTLCQYKFDFLQEVCQHEHFVPLCLPIRSANIPDPLTPSESTQELH DOC10_HUMAN DOC10_HUMAN MVNNYISMFSSGDFQTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELH A6NIW2_HUMAN A6NIW2_HUMAN LINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPM-------AFAKPKLQRVQ- DOC11_HUMAN DOC11_HUMAN LINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPM-------AFAKPKLQRVQ- A2AF67_MOUSE A2AF67_MOUSE LINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPM-------AFAKPKLQRVQD DOC11_MOUSE DOC11_MOUSE LINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPM-------AFAKPKLQRVQ- Q4S0A5_TETNG Q4S0A5_TETNG QINNYMNCFMPGDPKTLFEFKFEFLRVVCNHEHYVPLNLPM-------PFAKGRILRFQ- B2RY79_MOUSE B2RY79_MOUSE QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- B2RY08_MOUSE B2RY08_MOUSE QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- DOCK9_MOUSE DOCK9_MOUSE QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- B2RXS7_MOUSE B2RXS7_MOUSE QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- Q7TN11_MOUSE Q7TN11_MOUSE QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- A8MWZ5_HUMAN A8MWZ5_HUMAN QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- Q5REN3_PONAB Q5REN3_PONAB QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- B7ZVX0_HUMAN B7ZVX0_HUMAN QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- B9EG73_HUMAN B9EG73_HUMAN QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- DOCK9_HUMAN DOCK9_HUMAN QINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPM-------PFGKGRIQRYQ- MATCH :.:*:. : . : :.* : **:**: :*:***::** **: . CONSENSUS ?INNYIS?F???D?K?L?EYKFEFL??VCNHEHYIPL?LP????????P???????R???

Q4SPF3_TETNG Q4SPF3_TETNG ------------ASVPEYSLTGEFCRKHFLTGLLLRELGLALQDEQDLRHLALATLKTLM B2RWY0_MOUSE B2RWY0_MOUSE -----------ASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLM DOC10_MOUSE DOC10_MOUSE -----------ASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLM B3FL70_HUMAN B3FL70_HUMAN -----------ASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLM DOC10_HUMAN DOC10_HUMAN -----------ASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLM A6NIW2_HUMAN A6NIW2_HUMAN ------------DSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLL DOC11_HUMAN DOC11_HUMAN ------------DSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLL A2AF67_MOUSE A2AF67_MOUSE FFSFAVDRLTSVDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLL DOC11_MOUSE DOC11_MOUSE ------------DSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLL Q4S0A5_TETNG Q4S0A5_TETNG ------------DLQLDYSLTDDFCKNHFL------------------------------ B2RY79_MOUSE B2RY79_MOUSE ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLL B2RY08_MOUSE B2RY08_MOUSE ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLL DOCK9_MOUSE DOCK9_MOUSE ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLL B2RXS7_MOUSE B2RXS7_MOUSE ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLL Q7TN11_MOUSE Q7TN11_MOUSE ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLL A8MWZ5_HUMAN A8MWZ5_HUMAN ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLL Q5REN3_PONAB Q5REN3_PONAB ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLL B7ZVX0_HUMAN B7ZVX0_HUMAN ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLL B9EG73_HUMAN B9EG73_HUMAN ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLL DOCK9_HUMAN DOCK9_HUMAN ------------DLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLL MATCH :**::.::*::*** CONSENSUS ?????????????????YSLT?EFC??HFL?G?LLRE???ALQ?????R??A????KNL?

Q4SPF3_TETNG Q4SPF3_TETNG AKHSLDARYATREKQARIASLYLPLYGLILDNMPRFFLRD-LFPIYITSSDQGSRDD--- B2RWY0_MOUSE B2RWY0_MOUSE AKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKD-LYPFTVNTSNQGSRDD--- DOC10_MOUSE DOC10_MOUSE AKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKD-LYPFTVNTSNQGSRDD--- B3FL70_HUMAN B3FL70_HUMAN AKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKD-LYPFTVNTSNQGSRDD--- DOC10_HUMAN DOC10_HUMAN AKHSFDDRYRER-KQAQIASLYMPLYGMLLDNMPRIYLKD-LYPFTVNTSNQGSRDD--- A6NIW2_HUMAN A6NIW2_HUMAN IKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSA-SRDE--- DOC11_HUMAN DOC11_HUMAN IKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSA-SRDE--- A2AF67_MOUSE A2AF67_MOUSE IKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSA-SRDE--- DOC11_MOUSE DOC11_MOUSE IKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSA-SRDE--- Q4S0A5_TETNG Q4S0A5_TETNG ------------SQQARLATLYLPLFGLLQENVNRLNVKE-VSPFTINHFQV-RTPPSGV B2RY79_MOUSE B2RY79_MOUSE IKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNPGSI-VKDE--- B2RY08_MOUSE B2RY08_MOUSE IKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNPGSI-VKDE--- DOCK9_MOUSE DOCK9_MOUSE IKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNPGSI-VKDE--- B2RXS7_MOUSE B2RXS7_MOUSE IKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNPGSI-VKDE--- Q7TN11_MOUSE Q7TN11_MOUSE IKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNPGSI-VKDE--- A8MWZ5_HUMAN A8MWZ5_HUMAN IKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNAGMT-VKDE--- Q5REN3_PONAB Q5REN3_PONAB IKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNAGMT-VKDE--- B7ZVX0_HUMAN B7ZVX0_HUMAN IKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNAGMT-VKDE--- B9EG73_HUMAN B9EG73_HUMAN IKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNAGMT-VKDE--- DOCK9_HUMAN DOCK9_HUMAN IKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRD-VSPFPVNAGMT-VKDE--- MATCH :**::* **:*: *:: :*: *: :: : . CONSENSUS ?KH?FD?RY?????QA?IA?LYLPL?GLL??N??R????D???P???????????D????

Q4SPF3_TETNG Q4SPF3_TETNG -LSVGGG----VSRHGNSVDASFSKEVLNSITVRFDAPPPAAFSFLAVVSGNQTDSRGSL B2RWY0_MOUSE B2RWY0_MOUSE LSTNGGFQTQTSMKHATSVDTSFSKDVLNSIA---------AFSSIAISTVNHADSRASL DOC10_MOUSE DOC10_MOUSE LSTNGGFQTQTSMKHATSVDTSFSKDVLNSIA---------AFSSIAISTVNHADSRASL B3FL70_HUMAN B3FL70_HUMAN LSTNGGFQSQTAIKHANSVDTSFSKDVLNSIA---------AFSSIAISTVNHADSRASL DOC10_HUMAN DOC10_HUMAN LSTNGGFQSQTAIKHANSVDTSFSKDVLNSIA---------AFSSIAISTVNHADSRASL A6NIW2_HUMAN A6NIW2_HUMAN ---FPCG--FTSPANRGSLSTD-KDTAYGSFQ--------------NGHGIKREDSRGSL DOC11_HUMAN DOC11_HUMAN ---FPCG--FTSPANRGSLSTD-KDTAYGSFQ--------------NGHGIKREDSRGSL A2AF67_MOUSE A2AF67_MOUSE ---FPCG--FVSPTNRGSLASD-KDTAYGSFQ--------------NGHGIKREDSRGSL DOC11_MOUSE DOC11_MOUSE ---FPCG--FVSPTNRGSLASD-KDTAYGSFQ--------------NGHGIKREDSRGSL Q4S0A5_TETNG Q4S0A5_TETNG SINLQAFRIQRTLGPAPFLDTSLHKDVFGAIS---GTSSPHTSSTPNINSVRHADSRGSL B2RY79_MOUSE B2RY79_MOUSE ALAVPAGNPLMTPQKGNTLDHSLHKDLLGAIS---GIASPYTASTPNINSVRNADSRGSL B2RY08_MOUSE B2RY08_MOUSE ALAVPAGNPLMTPQKGNTLDHSLHKDLLGAIS---GIASPYTASTPNINSVRNADSRGSL DOCK9_MOUSE DOCK9_MOUSE ALAVPAGNPLMTPQKGNTLDHSLHKDLLGAIS---GIASPYTASTPNINSVRNADSRGSL B2RXS7_MOUSE B2RXS7_MOUSE ALAVPAGNPLMTPQKGNTLDHSLHKDLLGAIS---GIASPYTASTPNINSVRNADSRGSL Q7TN11_MOUSE Q7TN11_MOUSE ALAVPAGNPLMTPQKGNTLDHSLHKDLLGAIS---GIASPYTASTPNINSVRNADSRGSL A8MWZ5_HUMAN A8MWZ5_HUMAN SLALPAVNPLVTPQKGSTLDNSLHKDLLGAIS---GIASPYTTSTPNINSVRNADSRGSL Q5REN3_PONAB Q5REN3_PONAB SLALPAVNPLATPQKGSTLDNSLHKDLLGAIS---GIASPYTTSTPNINSVRNADSRGSL B7ZVX0_HUMAN B7ZVX0_HUMAN SLALPAVNPLVTPQKGSTLDNSLHKDLLGAIS---GIASPYTTSTPNINSVRNADSRGSL B9EG73_HUMAN B9EG73_HUMAN SLALPAVNPLVTPQKGSTLDNSLHKDLLGAIS---GIASPYTTSTPNINSVRNADSRGSL DOCK9_HUMAN DOCK9_HUMAN SLALPAVNPLVTPQKGSTLDNSLHKDLLGAIS---GIASPYTTSTPNINSVRNADSRGSL MATCH : . . .:: .. ***.** CONSENSUS ???????????????????D?S??K?????I????????????S??????????DSRGSL

Q4SPF3_TETNG Q4SPF3_TETNG ISMDSNLSNSDRNSEKMDGCEKFARPQSLIGYGSRCDKLDQAETRSLLMCFLHIMKTISE B2RWY0_MOUSE B2RWY0_MOUSE ASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISD DOC10_MOUSE DOC10_MOUSE ASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISD B3FL70_HUMAN B3FL70_HUMAN ASLDSNPSTNEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISY DOC10_HUMAN DOC10_HUMAN ASLDSNPSTNEKSSEKTDNCEKVPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISD A6NIW2_HUMAN A6NIW2_HUMAN IP-EGATGFPDQGNTGENTRQSSTRS-----SVSQYNRLDQYEIRSLLMCYLYIVKMISE DOC11_HUMAN DOC11_HUMAN IP-EGATGFPDQGNTGENTRQSSTRS-----SVSQYNRLDQYEIRSLLMCYLYIVKMISE A2AF67_MOUSE A2AF67_MOUSE IP-EGATGFPDPGSTSENTRQSSSRS-----SVSQYNRLDQYEIRNLLMCYLYIVKMISE DOC11_MOUSE DOC11_MOUSE IP-EGATGFPDPGSTSENTRQSSSRS-----SVSQYNRLDQYEIRNLLMCYLYIVKMISE Q4S0A5_TETNG Q4S0A5_TETNG ISTDSANSLSEKNHDKSNSLDKNHPAAALGSSLLRCDKLEQAEIKSLLMCFLHVLKSMSE B2RY79_MOUSE B2RY79_MOUSE ISTDSGNSLPDRNPEKSNSLDK-QQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSD B2RY08_MOUSE B2RY08_MOUSE ISTDSGNSLPDRNPEKSNSLDK-QQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSD DOCK9_MOUSE DOCK9_MOUSE ISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSD B2RXS7_MOUSE B2RXS7_MOUSE ISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSD Q7TN11_MOUSE Q7TN11_MOUSE ISTDSGNSLPDRNPEKSNSLDK-QQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSD A8MWZ5_HUMAN A8MWZ5_HUMAN ISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSD Q5REN3_PONAB Q5REN3_PONAB ISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSD B7ZVX0_HUMAN B7ZVX0_HUMAN ISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSD B9EG73_HUMAN B9EG73_HUMAN ISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSD DOCK9_HUMAN DOCK9_HUMAN ISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSD MATCH . :. . : . : :. . : ::*:* * :.****:*:::* :* CONSENSUS IS?DS??S???????K?????K??????L??S??R?DKLDQ?E??SLLMCFL???K??S?

Q4SPF3_TETNG Q4SPF3_TETNG DVLVSYWHRAIHQEISDFFSILELCLQHFRFLGKRHIARGVEI----------------- B2RWY0_MOUSE B2RWY0_MOUSE ETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGS DOC10_MOUSE DOC10_MOUSE ETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGS B3FL70_HUMAN B3FL70_HUMAN ETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGS DOC10_HUMAN DOC10_HUMAN ETLIAYWQRAPSPEVSDFFSILEVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGS A6NIW2_HUMAN A6NIW2_HUMAN DTLLTYWNKVSPQELINILILLEVCLFHFRYMGKRNIARVHDA----------------- DOC11_HUMAN DOC11_HUMAN DTLLTYWNKVSPQELINILILLEVCLFHFRYMGKRNIARVHDA----------------- A2AF67_MOUSE A2AF67_MOUSE DTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDA----------------- DOC11_MOUSE DOC11_MOUSE DTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDA----------------- Q4S0A5_TETNG Q4S0A5_TETNG DALFTYWSKASSADLMDFFTLIEVCLHQFRYMGKRYIARNQDG----------------- B2RY79_MOUSE B2RY79_MOUSE DALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIA---------------------- B2RY08_MOUSE B2RY08_MOUSE DALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIA---------------------- DOCK9_MOUSE DOCK9_MOUSE DALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIA---------------------- B2RXS7_MOUSE B2RXS7_MOUSE DALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARNQEG----------------- Q7TN11_MOUSE Q7TN11_MOUSE DALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARNQEG----------------- A8MWZ5_HUMAN A8MWZ5_HUMAN DALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIA---------------------- Q5REN3_PONAB Q5REN3_PONAB DALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARNQEG----------------- B7ZVX0_HUMAN B7ZVX0_HUMAN DALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIA---------------------- B9EG73_HUMAN B9EG73_HUMAN DALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIA---------------------- DOCK9_HUMAN DOCK9_HUMAN DALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIA---------------------- MATCH :.*.:** :. :: ::: : ::** :*:::*** * CONSENSUS D?L??YW??A???E??DFF???EVCL??F?Y?GKR?IA??????????????????????

Q4SPF3_TETNG Q4SPF3_TETNG ---KPGESGKKGGRMASSGGDGHRHARSQTMPIIRGKNALTNPKLLQMMETDGTI----- B2RWY0_MOUSE B2RWY0_MOUSE NPSCQTSGLLSQWMHTTSGHEGHKQHRSQTLPIIRGKNALSNPKLLQM--LDNSMNSN-- DOC10_MOUSE DOC10_MOUSE NPSCQTSGLLSQWMHTTSGHEGHKQHRSQTLPIIRGKNALSNPKLLQM--LDNSMNSN-- B3FL70_HUMAN B3FL70_HUMAN NPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLPIIRGKNALSNPKLLQM--LDNTMTSN-- DOC10_HUMAN DOC10_HUMAN NPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLPIIRGKNALSNPKLLQM--LDNTMTSN-- A6NIW2_HUMAN A6NIW2_HUMAN ------------WLSKHFGID----RKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHS DOC11_HUMAN DOC11_HUMAN ------------WLSKHFGID----RKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHS A2AF67_MOUSE A2AF67_MOUSE ------------WLSKHFGID----RKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHS DOC11_MOUSE DOC11_MOUSE ------------WLSKHFGID----RKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHS Q4S0A5_TETNG Q4S0A5_TETNG --------------AGPVIHE----RKSQTLPVSRNRAGMMHARLQQLSSLDNSYTFNHT B2RY79_MOUSE B2RY79_MOUSE -------------------------------------------SVRKISSV-LGISVDNG B2RY08_MOUSE B2RY08_MOUSE ------------------------------------RTGMMHARLQQLGSLDNSVTFNHS DOCK9_MOUSE DOCK9_MOUSE ------------------------------------RTGMMHARLQQLGSLDNSVTFNHS B2RXS7_MOUSE B2RXS7_MOUSE --------------LGPIGHD----RKSQTLPVSRNRTGMMHARLQQLGSLDNSVTFNHS Q7TN11_MOUSE Q7TN11_MOUSE --------------LGPIGHD----RKSQTLPVSRNRTGMMHARLQQLGSLDNSVTFNHS A8MWZ5_HUMAN A8MWZ5_HUMAN ------------------------------------RTGMMHARLQQLGSLDNSLTFNHS Q5REN3_PONAB Q5REN3_PONAB --------------LGPIVHD----RKSQTLPVSRNRTGMMHARLQQLGSLDNSLTFNHS B7ZVX0_HUMAN B7ZVX0_HUMAN ------------------------------------RTGMMHARLQQLGSLDNSLTFNHS B9EG73_HUMAN B9EG73_HUMAN ------------------------------------RTGMMHARLQQLGSLDNSLTFNHS DOCK9_HUMAN DOCK9_HUMAN ------------------------------------RTGMMHARLQQLGSLDNSLTFNHS MATCH : :: CONSENSUS ????????????????????????????????????????????L?????L??S?T?N??

Q4SPF3_TETNG Q4SPF3_TETNG ---QDGDNLSPTDIEANLSTEVALTVLDVLELFVHHHKKQLHLDEGQNSLMKKVLDTYLL B2RWY0_MOUSE B2RWY0_MOUSE --SNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMKRVFDTYML DOC10_MOUSE DOC10_MOUSE --SNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMKRVFDTYML B3FL70_HUMAN B3FL70_HUMAN --SNEIDIVHHVDTEANIATEVCLTILDLLSLFTQTHQRQLQQCDCQNSLMKRVFDTYML DOC10_HUMAN DOC10_HUMAN --SNEIDIVHHVDTEANIATEVCLTILDLLSLFTQTHQRQLQQCDCQNSLMKRVFDTYML A6NIW2_HUMAN A6NIW2_HUMAN STTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDGHNPLMKKVFDIHLA DOC11_HUMAN DOC11_HUMAN STTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDGHNPLMKKVFDIHLA A2AF67_MOUSE A2AF67_MOUSE SATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLA DOC11_MOUSE DOC11_MOUSE SATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLA Q4S0A5_TETNG Q4S0A5_TETNG YSHSDADVLNQSLLEANIATEVCLTVLDTLSIFIMGFKTQLCSDHGHSPLMKKVFEVHLC B2RY79_MOUSE B2RY79_MOUSE YGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC B2RY08_MOUSE B2RY08_MOUSE YGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC DOCK9_MOUSE DOCK9_MOUSE YGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC B2RXS7_MOUSE B2RXS7_MOUSE YGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC Q7TN11_MOUSE Q7TN11_MOUSE YGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC A8MWZ5_HUMAN A8MWZ5_HUMAN YGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC Q5REN3_PONAB Q5REN3_PONAB YGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC B7ZVX0_HUMAN B7ZVX0_HUMAN YGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC B9EG73_HUMAN B9EG73_HUMAN YGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC DOCK9_HUMAN DOCK9_HUMAN YGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLC MATCH : * . *.* :***.** ** :.:* .: ** . :..***:*:: :: CONSENSUS ??????D??H????EAN?ATEV?LT?LD?LS?FT???K?QL????G?N?LMKKVFD??L?

Q4SPF3_TETNG Q4SPF3_TETNG FFQINQSTATLRHVFAALRLFVQKVQHPQCTPVNQAPCHLAFEKTQHLGVFFSHFQFPSA B2RWY0_MOUSE B2RWY0_MOUSE FFQVNQSASALKHVFASLRLFV--------------------------------CKFPSA DOC10_MOUSE DOC10_MOUSE FFQVNQSASALKHVFASLRLFV--------------------------------CKFPSA B3FL70_HUMAN B3FL70_HUMAN FFQVNQSATALKHVFASLRLFV--------------------------------CKFPSA DOC10_HUMAN DOC10_HUMAN FFQVNQSATALKHVFASLRLFV--------------------------------CKFPSA A6NIW2_HUMAN A6NIW2_HUMAN FLKNGQSEVSLKHVFASLRAFI--------------------------------SKFPSA DOC11_HUMAN DOC11_HUMAN FLKNGQSEVSLKHVFASLRAFI--------------------------------SKFPSA A2AF67_MOUSE A2AF67_MOUSE FLKNGQSEVSLKHVFASLRSFI--------------------------------SKFPSA DOC11_MOUSE DOC11_MOUSE FLKNGQSEVSLKHVFASLRSFI--------------------------------SKFPSA Q4S0A5_TETNG Q4S0A5_TETNG FLRINQSETALKQVFTSLRTFI--------------------------------YKFPCT B2RY79_MOUSE B2RY79_MOUSE FLQKHQSEMALKNVFTALRSLI--------------------------------YKFPSA B2RY08_MOUSE B2RY08_MOUSE FLQKHQSEMALKNVFTALRSLI--------------------------------YKFPSA DOCK9_MOUSE DOCK9_MOUSE FLQKHQSEMALKNVFTALRSLI--------------------------------YKFPSA B2RXS7_MOUSE B2RXS7_MOUSE FLQKHQSEMALKNVFTALRSLI--------------------------------YKFPSA Q7TN11_MOUSE Q7TN11_MOUSE FLQKHQSEMALKNVFTALRSLI--------------------------------YKFPSA A8MWZ5_HUMAN A8MWZ5_HUMAN FLQKHQSETALKNVFTALRSLI--------------------------------YKFPST Q5REN3_PONAB Q5REN3_PONAB FLQKHQSETALKNVFTALRSLI--------------------------------YKFPST B7ZVX0_HUMAN B7ZVX0_HUMAN FLQKHQSETALKNVFTALRSLI--------------------------------YKFPST B9EG73_HUMAN B9EG73_HUMAN FLQKHQSETALKNVFTALRSLI--------------------------------YKFPST DOCK9_HUMAN DOCK9_HUMAN FLQKHQSETALKNVFTALRSLI--------------------------------YKFPST MATCH *:: ** :*::**::** :: :**.: CONSENSUS F????QS???LK?VF??LR????????????????????????????????????KFPS?

Q4SPF3_TETNG Q4SPF3_TETNG FFQGKADLCGCLCYEILKCCNHRSSSTQTEASALLYFFMRKNFEFTKGKSIVRSHLQVIK B2RWY0_MOUSE B2RWY0_MOUSE FFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIK DOC10_MOUSE DOC10_MOUSE FFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIK B3FL70_HUMAN B3FL70_HUMAN FFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIK DOC10_HUMAN DOC10_HUMAN FFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIK A6NIW2_HUMAN A6NIW2_HUMAN FFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIII DOC11_HUMAN DOC11_HUMAN FFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIII A2AF67_MOUSE A2AF67_MOUSE FFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIII DOC11_MOUSE DOC11_MOUSE FFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIII Q4S0A5_TETNG Q4S0A5_TETNG FFEGRADMCAAFCYEILKCCNSKLSSIRSDAAHLLYFLMKNNFDYTARKSFVRTHLQVVI B2RY79_MOUSE B2RY79_MOUSE FYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII B2RY08_MOUSE B2RY08_MOUSE FYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII DOCK9_MOUSE DOCK9_MOUSE FYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII B2RXS7_MOUSE B2RXS7_MOUSE FYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII Q7TN11_MOUSE Q7TN11_MOUSE FYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII A8MWZ5_HUMAN A8MWZ5_HUMAN FYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII Q5REN3_PONAB Q5REN3_PONAB FYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII B7ZVX0_HUMAN B7ZVX0_HUMAN FYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII B9EG73_HUMAN B9EG73_HUMAN FYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII DOCK9_HUMAN DOCK9_HUMAN FYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVII MATCH *::* .::*..:***:****. : : :*: ***::*::**::. *:::*:***:: CONSENSUS F??G?AD?C???CYE?LKCCN???SS???EAS?LLYF?MR?NF??T??KS?VR?HLQ?I?

Q4SPF3_TETNG Q4SPF3_TETNG AVSQLIAD-AGIGGSRFQQSLAIINNFANGDAPLKNTPFPAEVKDLTKRIRTVLMATAQM B2RWY0_MOUSE B2RWY0_MOUSE AVSQLIAD-AGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQM DOC10_MOUSE DOC10_MOUSE AVSQLIAD-AGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQM B3FL70_HUMAN B3FL70_HUMAN AVSQLIAD-AGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQM DOC10_HUMAN DOC10_HUMAN AVSQLIAD-AGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQM A6NIW2_HUMAN A6NIW2_HUMAN AVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQM DOC11_HUMAN DOC11_HUMAN AVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQM A2AF67_MOUSE A2AF67_MOUSE AVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQM DOC11_MOUSE DOC11_MOUSE AVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQM Q4S0A5_TETNG Q4S0A5_TETNG AVSQLIADVIGIGSTRFQQSLSIINNCANSDKTIKNTAFPSDVKDLTKRIRTVLMATAQM B2RY79_MOUSE B2RY79_MOUSE SVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQM B2RY08_MOUSE B2RY08_MOUSE SVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQM DOCK9_MOUSE DOCK9_MOUSE SVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQM B2RXS7_MOUSE B2RXS7_MOUSE SVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQM Q7TN11_MOUSE Q7TN11_MOUSE SVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQM A8MWZ5_HUMAN A8MWZ5_HUMAN SVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQM Q5REN3_PONAB Q5REN3_PONAB SVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQM B7ZVX0_HUMAN B7ZVX0_HUMAN SVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQM B9EG73_HUMAN B9EG73_HUMAN SVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQM DOCK9_HUMAN DOCK9_HUMAN SVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQM MATCH :******* *.:***.** * ** **.* :* : *.::****************** CONSENSUS ?VSQLIAD??GIGG?RFQ?SL?IINN?AN?D???K?T?F???VKDLTKRIRTVLMATAQM

Q4SPF3_TETNG Q4SPF3_TETNG KEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKVHVRNGDLSEAAMCYIHISALIA B2RWY0_MOUSE B2RWY0_MOUSE KEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIA DOC10_MOUSE DOC10_MOUSE KEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIA B3FL70_HUMAN B3FL70_HUMAN KEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIA DOC10_HUMAN DOC10_HUMAN KEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIA A6NIW2_HUMAN A6NIW2_HUMAN KEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVA DOC11_HUMAN DOC11_HUMAN KEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVA A2AF67_MOUSE A2AF67_MOUSE KEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVA DOC11_MOUSE DOC11_MOUSE KEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVA Q4S0A5_TETNG Q4S0A5_TETNG KEHERDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVAALVA B2RY79_MOUSE B2RY79_MOUSE