Alignment of the gene Family HBG107854 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
ERC6L_MOUSE ERC6L_MOUSE EASQGLAEVETLSPQLAESYLRYVQEAKEAAKNGDLEESLKLFNLAKDIFPTKKVMSRIQ ERC6L_BOVIN ERC6L_BOVIN EVSRGFAEAGALSPEQAASYLRYVKEAKEATKNGDLEQALKLFNLAKDIFPNEKVMSRIQ B5MDQ0_HUMAN B5MDQ0_HUMAN ------------------------------------------------------------ ERC6L_HUMAN ERC6L_HUMAN EASRRFPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQ MATCH CONSENSUS ????????????????????????????????????????????????????????????

ERC6L_MOUSE ERC6L_MOUSE KLQEALEQLAEEEDDDEFIDVCSSGLLLYRELYEKLFEHQKEGIAFLYSLYKDGRKGGIL ERC6L_BOVIN ERC6L_BOVIN KIQEALEELA-EHGDDEFIDVCNSGLLLYQELHNQLYEYQKEGIAFLYSLYRDGRRGGIL B5MDQ0_HUMAN B5MDQ0_HUMAN ------------------------------------------------------------ ERC6L_HUMAN ERC6L_HUMAN KIQEALEELA-EQGDDEFTDVCNSGLLLYRELHNQLFEHQKEGIAFLYSLYRDGRKGGIL MATCH CONSENSUS ????????????????????????????????????????????????????????????

ERC6L_MOUSE ERC6L_MOUSE ADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVNEFAKWTPGMRVKTFHGSS ERC6L_BOVIN ERC6L_BOVIN ADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTSLISTWLREFVKWTPGMRVKTFHGPS B5MDQ0_HUMAN B5MDQ0_HUMAN ---MGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGPS ERC6L_HUMAN ERC6L_HUMAN ADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGPS MATCH *******************************.**.**:.** *************.* CONSENSUS ???MGLGKTVQIIAFLSGMFDASLVNHVLLIMPT?LI?TW??EF?KWTPGMRVKTFHG?S

ERC6L_MOUSE ERC6L_MOUSE KSERTRSLTRIQQRNGVVITTYQMLLNNWQQLASFNGQAFVWDYVILDEAHKIKSASTKS ERC6L_BOVIN ERC6L_BOVIN KDERTRNLCRIQQRNGVIITTYQMLINNWQQLSSLNGQEFLWDYVILDEAHKIKSSSTKS B5MDQ0_HUMAN B5MDQ0_HUMAN KDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKS ERC6L_HUMAN ERC6L_HUMAN KDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKS MATCH *.****.* ********:*******:******:*:.** *:*************::**** CONSENSUS K?ERTR?L?RIQQRNGV?ITTYQML?NNWQQL?S??GQ?F?WDYVILDEAHKIK??STKS

ERC6L_MOUSE ERC6L_MOUSE AVCARAIPASNRLLLTGTPVQNNLQELWSLFDFACQGSLLGTLKTFKMEYEHPIIRAREK ERC6L_BOVIN ERC6L_BOVIN AICARAIPASNRILLTGTPIQNNLQELWSLFDFACQGSLLGTLRTFKMEYENPITRAREK B5MDQ0_HUMAN B5MDQ0_HUMAN AICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREK ERC6L_HUMAN ERC6L_HUMAN AICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREK MATCH *:**********:******:***********************:*******:** ***** CONSENSUS A?CARAIPASNR?LLTGTP?QNNLQELWSLFDFACQGSLLGTL?TFKMEYE?PI?RAREK

ERC6L_MOUSE ERC6L_MOUSE DATPGEKALGLKISENLMEIIKPYFLRRTKEEVQTKKADNPEARLGEKNPAGEAICDMFS ERC6L_BOVIN ERC6L_BOVIN DATPGEKALGFKISENLMAIIKPYFLRRTKEEVQKKKSSNPEVQLSEKSPDVGAICEMPS B5MDQ0_HUMAN B5MDQ0_HUMAN DATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPS ERC6L_HUMAN ERC6L_HUMAN DATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPS MATCH **********:******* ************:**.**:.***.:*.**.* ***:* * CONSENSUS DATPGEKALG?KISENLM?IIKPYFLRRTKE?VQ?KK??NPE??L?EK?P???AIC?M?S

ERC6L_MOUSE ERC6L_MOUSE LARKNDLIVWIRLLPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSAR ERC6L_BOVIN ERC6L_BOVIN LSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSAR B5MDQ0_HUMAN B5MDQ0_HUMAN LSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSAR ERC6L_HUMAN ERC6L_HUMAN LSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSAR MATCH *:******:****:********************************************** CONSENSUS L?RKNDLI?WIRL?PLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSAR

ERC6L_MOUSE ERC6L_MOUSE ACRLLNLGTATFSAQDENEQEDVSNMNSIDHLPDKTLIQESGKMIFLMSLLERLQDEGHQ ERC6L_BOVIN ERC6L_BOVIN ACGLLNLGAAKFSVQDEIEGEDSSDVDHIDQISDDTLMEESGKMLFLMDLLKKLRDEGHQ B5MDQ0_HUMAN B5MDQ0_HUMAN ACCLLNLGT--FSAQDGNEGEDSPDVDHIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQ ERC6L_HUMAN ERC6L_HUMAN ACCLLNLGT--FSAQDGNEGEDSPDVDHIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQ MATCH ** *****: **.** * ** .::: **::.*.**::*****:***.**::*:***** CONSENSUS AC?LLNLG???FS?QD??E?ED??????ID???D?TL??ESGKM?FLM?LL??L?DEGHQ

ERC6L_MOUSE ERC6L_MOUSE TLVFSQSIKILNIIERLLKNKHFKTLRIDGTVTHLWEREKRIQLFQQNKEYSVFLLTTQV ERC6L_BOVIN ERC6L_BOVIN TLVFSQSRRILNIIERLLKNRHFKILRIDGTITHLVEREKRISLFQQNKDYSVFLLTTQV B5MDQ0_HUMAN B5MDQ0_HUMAN TLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQV ERC6L_HUMAN ERC6L_HUMAN TLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQV MATCH ******* :***********:*** ******:*** ******.******:********** CONSENSUS TLVFSQS??ILNIIERLLKN?HFK?LRIDGT?THL?EREKRI?LFQQNK?YSVFLLTTQV

ERC6L_MOUSE ERC6L_MOUSE GGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQ ERC6L_BOVIN ERC6L_BOVIN GGVGLTLTAASRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQ B5MDQ0_HUMAN B5MDQ0_HUMAN GGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQ ERC6L_HUMAN ERC6L_HUMAN GGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQ MATCH **********:************************************************* CONSENSUS GGVGLTLTAA?RVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQ

ERC6L_MOUSE ERC6L_MOUSE VFKDSLIRQTTGEKKNPFRYFTKQELKELFTVGDLQKSATQMQLQCLHAAQRRSDEKLDE ERC6L_BOVIN ERC6L_BOVIN VFKDSLIRQTTGDKKNPFRYFSKQELRELFTIEDFQNSATQLQLQSLHAAQRRSDKNLDE B5MDQ0_HUMAN B5MDQ0_HUMAN VFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAAQRKSDIKLDE ERC6L_HUMAN ERC6L_HUMAN VFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAAQRKSDIKLDE MATCH ************:********:****:****: *:*:*.**:***.******:** :*** CONSENSUS VFKDSLIRQTTG?KKNPFRYF?KQEL?ELFT??D?Q?S?TQ?QLQ?LHAAQR?SD??LDE

ERC6L_MOUSE ERC6L_MOUSE HIAYLHLLGIAGISDHDLMFTRDLSVKEELDMLEDSQYIHQRVQKAQFLVESESQNT--- ERC6L_BOVIN ERC6L_BOVIN HIAFLHSLRIAGISDHDLMYTRDLSVKEELDVIEDSHYIQQRVQKAQFLVESESQNTELL B5MDQ0_HUMAN B5MDQ0_HUMAN HIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQNKEFL ERC6L_HUMAN ERC6L_HUMAN HIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQNKEFL MATCH ***:*: * **********:* *********::*:*:**:*********** ****. CONSENSUS HIA?L??L?IAGISDHDLM?T?DLSVKEELD??E?S?YI?QRVQKAQFLVE?ESQN????

ERC6L_MOUSE ERC6L_MOUSE VQRQTTGIEETWLKAQEFPSQQKKKGTEFNKPQPQPSRLL-TKPTQVEAISSQMASITIC ERC6L_BOVIN ERC6L_BOVIN MERQKMGNEGIWLREPVY--QTKKKRPKVNKPQPQPSSHLPVYHTQEE-ISSLMASIIID B5MDQ0_HUMAN B5MDQ0_HUMAN MEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMASVVID ERC6L_HUMAN ERC6L_HUMAN MEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMASVVID MATCH :::* * **: : . *** .:.******** * . ** * *** ***: * CONSENSUS ???Q????E??WL?????????KKK????NKPQPQPS??L????TQ?E?ISS?MAS??I?

ERC6L_MOUSE ERC6L_MOUSE DQSAESEPQEHS--EVHDVTSLQGSHHFNSTSDAGTIASLPQGAESIGEVSTDSLLSPAK ERC6L_BOVIN ERC6L_BOVIN DLPKEDEK-DLSRIKLNDTIPQDGRHPCVITLNDDFVTTLPKGCGDVEEIFPDSLSGM-- B5MDQ0_HUMAN B5MDQ0_HUMAN DLPKEGEKQDLSSIKVNVTTLQDGK----GTGSADSIATLPKGFGSVEELCTNSSLGMEK ERC6L_HUMAN ERC6L_HUMAN DLPKEGEKQDLSSIKVNVTTLQDGK----GTGSADSIATLPKGFGSVEELCTNSSLGMEK MATCH * . *.* : * ::: . :* * . . :::**:* .: *: .:* . CONSENSUS D???E?E????S???????????G??????T????????LP?G?????E????S??????

ERC6L_MOUSE ERC6L_MOUSE GFAAENDAMQKKGLQASPGQEAPSEN-LGSFHYLPRESSKASLGPNLD-LQDSVVLYHRS ERC6L_BOVIN ERC6L_BOVIN -------ALQKEASQEGFMQESEQESPLASFNYLPSKSARVDLGPNLDQLEDDEVLHHCN B5MDQ0_HUMAN B5MDQ0_HUMAN SFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCN ERC6L_HUMAN ERC6L_HUMAN SFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCN MATCH *:**: * . **: .*. * **:*: :*::..:***** *:*. :* * . CONSENSUS ???????A?QK???Q????QE???E??L?SF?Y????S?????GPNLD?L?D???L?H??

ERC6L_MOUSE ERC6L_MOUSE P-----TANENQNLESDVPMIEIS-DDLSEPPSALQGAQAIEAQLELKEDDPLKSPPQYA ERC6L_BOVIN ERC6L_BOVIN PSPANPKTKEYQRPESNVSVIKIADDDLTAAHSALQDAQANEAKL---EEEPLASSGQYA B5MDQ0_HUMAN B5MDQ0_HUMAN PWPIISITNESQNAESNVSIIEIA-DDLSASHSALQDAQASEAKL---EEEPSASSPQYA ERC6L_HUMAN ERC6L_HUMAN PWPIISITNESQNAESNVSIIEIA-DDLSASHSALQDAQASEAKL---EEEPSASSPQYA MATCH * ::* *. **:*.:*:*: ***: . ****.*** **:* *::* *. *** CONSENSUS P????????E?Q??ES?V??I?I??DDL????SALQ?AQA?EA?L???E??P??S??QYA

ERC6L_MOUSE ERC6L_MOUSE CDFNLFLEDSADTRQNLSSKFLEHVEKEKSLQSPAANSRAKSALT---LSLDSSPKSDEE ERC6L_BOVIN ERC6L_BOVIN CDFNLFLEDSADNGQNLSSQFLEHVEKENSLCGSAANSRAESVHSKACLSVDLSEEDDEP B5MDQ0_HUMAN B5MDQ0_HUMAN CDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEP ERC6L_HUMAN ERC6L_HUMAN CDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEP MATCH ************. **:**: *******:** ..*.**** . : ** : * :.** CONSENSUS CDFNLFLEDSAD??QN?SS??LEHVEKE?SL???A?NSRA????????LS???S???DE?

ERC6L_MOUSE ERC6L_MOUSE SE-VISVKTKSKTRRILSDDEDEDEEDAFKG-SHTNSINISPFPFSSVKQFDASTPQSGS ERC6L_BOVIN ERC6L_BOVIN EE-VVNVKIRRKARRIDSDNEDE---HTFKDTSSTNPFNTSPFPFLSVKQFDASTPKNDI B5MDQ0_HUMAN B5MDQ0_HUMAN EEVVVKAKIRSKARRIVSDGEDED--DSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDI ERC6L_HUMAN ERC6L_HUMAN EEVVVKAKIRSKARRIVSDGEDED--DSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDI MATCH .* *:..* : *:*** **.*** .:**. * *.:* * * * **********:.. CONSENSUS ?E?V???K???K?RRI?SD?EDE?????FK??S??N??N?S?F?F?SVKQFDASTP????

ERC6L_MOUSE ERC6L_MOUSE NPSRRFFSPKTPGEVNTSLHSRRSLASRRSLINVVLDDVEDMEERLDNSSEEESEPGLSE ERC6L_BOVIN ERC6L_BOVIN SLPERFFSPKISDSINKSVNSRRSLASRRSLINVVLDHVEDMEERLDNSSEAKVVEDHLE B5MDQ0_HUMAN B5MDQ0_HUMAN SPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPE ERC6L_HUMAN ERC6L_HUMAN SPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPE MATCH . . ****.: ...:*.*::*************:***.*********:*** : . * CONSENSUS ????RFFS???????N?S??SRRSLASRRSLIN?VLD?VEDMEERLD?SSE????????E

ERC6L_MOUSE ERC6L_MOUSE ENNEE---EALACTEEQPSGATLASGNKSSNLTMSEPTSPAPQSSPCAPEPSSSDPMPDP ERC6L_BOVIN ERC6L_BOVIN EGAEESGDEAPEHTKEDPSRETLSSENKSSQLSTSKPGALAQETSPGDPEPLSDGQLVDS B5MDQ0_HUMAN B5MDQ0_HUMAN EGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGS ERC6L_HUMAN ERC6L_HUMAN EGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGS MATCH *. ** ** *:*:** **:* **** * *:* : * ::* *** *. : .. CONSENSUS E??EE???EA???T?E?PS??TL?S?NKSS?L??S?P???A???S???PEP?S???????

ERC6L_MOUSE ERC6L_MOUSE PQDLAVEAGNDYESLVARGKELKECGKIQEALNCLVKALDIKSADPEVMLMTLSLYKQLN ERC6L_BOVIN ERC6L_BOVIN PQDEAMEAVNDYDTLVLHGKELKECGKIQEALDCLVKALDIKSSDPEVMLMTLSLYKQLN B5MDQ0_HUMAN B5MDQ0_HUMAN PQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLN ERC6L_HUMAN ERC6L_HUMAN PQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLN MATCH *** * ** ***::** :**************:**********:******:********* CONSENSUS PQD?A?EA?NDY??LV??GKELKECGKIQEAL?CLVKALDIKS?DPEVML?TLSLYKQLN

ERC6L_MOUSE ERC6L_MOUSE I- ERC6L_BOVIN ERC6L_BOVIN KT B5MDQ0_HUMAN B5MDQ0_HUMAN NN ERC6L_HUMAN ERC6L_HUMAN NN MATCH CONSENSUS ??


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