Alignment of the gene Family HOG000007831 of HOGENOM

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Isoforms are ON
ACYPI_13021_PE4 NOISO ------------------------------------------------------------ AILMEGL192446_1_1_PE4 NOISO ------------------------------------------------------------ ANOCA3_12_PE8 NOISO ------------------------------------------------------------ BOVIN12_84_PE1 NOISO ------------------------------------------------------------ CALJA1_24_PE3 ENSCJAG00000014689 ------------------------------------------------------------ CALJA1_24_PE4 ISOFORMIN ------------------------------------------------------------ CANFA22_61_PE1 NOISO ------------------------------------------------------------ CAOWC1_1_4653 NOISO SGSLGERRLVGVKIEPPSSDAAAAGAAAAGAADPRLLLGNRASNKASASGLHFHAKKADA CAVPO5_18_PE4 NOISO ------------------------------------------------------------ CHICK1_PE2311 NOISO ------------------------------------------------------------ CIOSAREFTIG_1_3_PE120 NOISO ------------------------------------------------------------ DANRE1_29_PE19 NOISO ------------------------------------------------------------ ECHTE287220_PE1 NOISO ------------------------------------------------------------ FUGRU64_1_PE62 NOISO ------------------------------------------------------------ GASACGROUPI_22_PE33 NOISO ------------------------------------------------------------ GORGO13_95_PE1 NOISO ------------------------------------------------------------ HORSE17_78_PE2 NOISO ------------------------------------------------------------ HS13_PE971 ENSG00000174405 ------------------------------------------------------------ HS13_PE972 ISOFORMIN ------------------------------------------------------------ HS13_PE973 ISOFORMIN ------------------------------------------------------------ LOXAF29_29_PE2 NOISO ------------------------------------------------------------ MACMU17_91_PE2 ENSMMUG00000008874 ------------------------------------------------------------ MACMU17_91_PE3 ISOFORMIN ------------------------------------------------------------ MACMU17_91_PE4 ISOFORMIN ------------------------------------------------------------ MICMUGS_3684_1_PE1 NOISO ------------------------------------------------------------ MONDO7_88_PE3 NOISO ------------------------------------------------------------ MOUSE8_PE100 NOISO ------------------------------------------------------------ NEMVE_3080_PE8 NOISO ------------------------------------------------------------ OCHPRGS_4191_PE1 NOISO ------------------------------------------------------------ ORYLA2_24_PE32 NOISO ------------------------------------------------------------ PANTR13_111_PE1 NOISO ------------------------------------------------------------ PEDHC_895_PE28 NOISO ------------------------------------------------------------ PIG11_78_PE2 NOISO ------------------------------------------------------------ POEGU1_36_PE9 NOISO ------------------------------------------------------------ PONPY13RD_5_PE1 NOISO ------------------------------------------------------------ PTEVAGS_3160_PE1 NOISO ------------------------------------------------------------ RABIT8_113_PE3 NOISO ------------------------------------------------------------ RAT16_PE902 NOISO ------------------------------------------------------------ SORAR229595_PE1 NOISO ------------------------------------------------------------ SPIPN_1_834 NOISO ------------------------------------------------------------ STRPU_5557_PE5 NOISO ------------------------------------------MNRCCT--IVLC------ TARSY13215_PE1 NOISO ------------------------------------------------------------ TETNG3_PE307 NOISO ------------------------------------------------------------ THTRA1_1_9125 NOISO ------------------------------------------------------------ TRIAD_735_PE506 NOISO ------------------------------------------------------------ TUPGBGS_4574_1_PE1 NOISO ------------------------------------------------------------ TURTRGS_2813_PE1 NOISO ------------------------------------------------------------ XENTR42_2_PE40 NOISO ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

ACYPI_13021_PE4 NOISO -----------------------------------------------------MASTISK AILMEGL192446_1_1_PE4 NOISO ----------------------------------------------FTTISMAASHTSPT ANOCA3_12_PE8 NOISO ------------------------------------------------------------ BOVIN12_84_PE1 NOISO ----------------------------------------------FTIASMAASQTSQT CALJA1_24_PE3 ENSCJAG00000014689 ---------------------------------------------------MAASQTSQT CALJA1_24_PE4 ISOFORMIN ---------------------------------------------------MAASQTSQT CANFA22_61_PE1 NOISO ---------------------------------------------------MAATQTSQT CAOWC1_1_4653 NOISO ADDDAQNDDDKDDDDDDDKHHPASDRSDGGVLNPATGD-----LADHRRMDNSDIPPEGN CAVPO5_18_PE4 NOISO ---------------------------------------------------MAASQTSQT CHICK1_PE2311 NOISO ----------------------------------------------MASAPVSQPSPKRT CIOSAREFTIG_1_3_PE120 NOISO ----------------------------------------------TSTGAVKHYNEADG DANRE1_29_PE19 NOISO ----------------------------------------------MESVSKSDAKPQAF ECHTE287220_PE1 NOISO ------------------------------------------------------------ FUGRU64_1_PE62 NOISO ----------------------------------------------MEGTSRSDAAAEPS GASACGROUPI_22_PE33 NOISO ----------------------------------------------TMEEASSDAAGRPV GORGO13_95_PE1 NOISO ---------------------------------------------------MAASQTSQT HORSE17_78_PE2 NOISO -----------------------------------------------------------T HS13_PE971 ENSG00000174405 ---------------------------------------------------MAASQTSQT HS13_PE972 ISOFORMIN ---------------------------------------------------MAASQTSQT HS13_PE973 ISOFORMIN ---------------------------------------------------MAASQTSQT LOXAF29_29_PE2 NOISO ---------------------------------------------------VAASQTSPA MACMU17_91_PE2 ENSMMUG00000008874 ------------------------------------------------------------ MACMU17_91_PE3 ISOFORMIN ------------------------------------------------------------ MACMU17_91_PE4 ISOFORMIN ------------------------------------------------------------ MICMUGS_3684_1_PE1 NOISO ---------------------------------------------------MAASQTSQT MONDO7_88_PE3 NOISO ---------------------------------------------------MATSQPSRT MOUSE8_PE100 NOISO ---------------------------------------------------MASSQTSQT NEMVE_3080_PE8 NOISO ----------------------------------------------------MADSRSPS OCHPRGS_4191_PE1 NOISO ---------------------------------------------------MAASHTSQT ORYLA2_24_PE32 NOISO ---------------------------------------------MDDAPSKSDAASEQT PANTR13_111_PE1 NOISO ---------------------------------------------------MAASQTSQT PEDHC_895_PE28 NOISO ----------------------------------------------------------MS PIG11_78_PE2 NOISO ---------------------------------------------------MAASQASKT POEGU1_36_PE9 NOISO ----------------------------------------------------VSQPPKKT PONPY13RD_5_PE1 NOISO ---------------------------------------------------MAASQTSQT PTEVAGS_3160_PE1 NOISO ---------------------------------------------------MAASPTSQT RABIT8_113_PE3 NOISO ---------------------------------------------------MAASQTAQT RAT16_PE902 NOISO ---------------------------------------------------MASSQASRT SORAR229595_PE1 NOISO ---------------------------------------------------MATTPASPT SPIPN_1_834 NOISO ---------------------------MLNALAYR---------GD-MEGEDEQTAQGPD STRPU_5557_PE5 NOISO -----------------------SVDLDLDVLAYCTMASADQQPTSCTSTGASTEPEGPT TARSY13215_PE1 NOISO ---------------------------------------------------MAASQTPET TETNG3_PE307 NOISO ----------------------------------------------MEGPSRSDAAAQLS THTRA1_1_9125 NOISO ---------------------------MASILPT---------TTSSVAVGASGGDDGET TRIAD_735_PE506 NOISO -------------------------------------------------------MATKT TUPGBGS_4574_1_PE1 NOISO ---------------------------------------------------MAASQTSQT TURTRGS_2813_PE1 NOISO ---------------------------------------------------MAASQTSQT XENTR42_2_PE40 NOISO ----------------------------------------------MSATKASDSAAERT MATCH CONSENSUS ????????????????????????????????????????????????????????????

ACYPI_13021_PE4 NOISO PCNKIPFELFCRVCEDIYNAKNE-KKVL-ILEKFISKCRGSIE--KSDNLNIEDTFYPVL AILMEGL192446_1_1_PE4 NOISO VASRVPFADLCSTLERIQRSRERAAKIR-HFREFLDSWRRFHDALHKNQRDVSDSFYPAM ANOCA3_12_PE8 NOISO -----------------------------------------------------------M BOVIN12_84_PE1 NOISO VASHVPFADLCSTLERIQKSKGRAEKIR-HFKAFLDSWRKFHNALHKNQKDVTDSFYPAM CALJA1_24_PE3 ENSCJAG00000014689 VASHVPFADLCSTLERIQKTKGRAEKIR-HFREFLDSWRNFHDALHKNQKDVTDSFYPAM CALJA1_24_PE4 ISOFORMIN VASHVPFADLCSTLERIQKTKGRAEKIR-HFREFLDSWRNFHDALHKNQKDVTDSFYPAM CANFA22_61_PE1 NOISO VASHVPFADLCSTLERIQRSKGREEKIR-HFREFLDSWRRFHDALHKNQKDVRDSFYPAM CAOWC1_1_4653 NOISO CGDSVPFAAVATLLEQISSDTKRSVKQN-VLGSFLQRWRENGK------SNPNTTVFPIV CAVPO5_18_PE4 NOISO VASHVPFADLCSTLERIQKSKGRAEKIR-HFKEFLDSWRKFHDALHKNQKDVKDSFYPAM CHICK1_PE2311 NOISO VASHVPFADLCSTLERIQTCKSRPEKTK-YFKDFLDSWRKFHSALHQKEKDVTDSFYPAM CIOSAREFTIG_1_3_PE120 NOISO VASKIPFHQLCQLFEKIHKAKSKYTQRF-KLKTFLSKWRDLQRKFQVD--GKTGTCYPAI DANRE1_29_PE19 NOISO VAAQVPFIHLCTVLEKIQKTKLRPDKSK-ILKEFIDSWRNFHAALHKDNPDTADSFYAVM ECHTE287220_PE1 NOISO -ASQVPFADLCSTLERIQRSKGRAEKIR-HFKEFLDSWRKFHDALHKNQKNVTDSFYPAM FUGRU64_1_PE62 NOISO VAAQVPFVHLCTTLEKIQKAKLRPDKSK-ILGDFIGSWRKFHSALHKES-KTTDSFYPAM GASACGROUPI_22_PE33 NOISO VAARVPFLHLCNTLEKIQKSKLRPEKSK-ILGDFIESWRNFHSALHKDNPKTTDSFYSAM GORGO13_95_PE1 NOISO VASHVPFADLCSTLERIQKSRGRAEKIR-HFREFLDSWRKFHDALHKNHKDVTDSFYPAM HORSE17_78_PE2 NOISO VASHVPFADLCSTLERIQKSKGRAEKIR-HFKEFLDSWRKFHDALHKNQKDVTDSFYPAM HS13_PE971 ENSG00000174405 VASHVPFADLCSTLERIQKSKGRAEKIR-HFREFLDSWRKFHDALHKNHKDVTDSFYPAM HS13_PE972 ISOFORMIN VASHVPFADLCSTLERIQKSKGRAEKIR-HFREFLDSWRKFHDALHKNHKDVTDSFYPAM HS13_PE973 ISOFORMIN VASHVPFADLCSTLERIQKSKGRAEKIR-HFREFLDSWRKFHDALHKNHKDVTDSFYPAM LOXAF29_29_PE2 NOISO VASHVPFADLCSTLERIQRSRGRAEKIK-HFQEFLDSWRKFHDALHKNQKDVTDSFYPAM MACMU17_91_PE2 ENSMMUG00000008874 -ASHVPFADLCSTLERIQKSRGRAEKIR-HFREFLDSWRKFHDALHKNQKDVTDSFYPAM MACMU17_91_PE3 ISOFORMIN ----VPFADLCSTLERIQKSRGRAEKIR-HFR-------KFHDALHKNQKDVTDSFYPAM MACMU17_91_PE4 ISOFORMIN ----VPFADLCSTLERIQKSRGRAEKIR-HFR-------KFHDALHKNQKDVTDSFYPAM MICMUGS_3684_1_PE1 NOISO VASHVPFADLCSTLERIQKSKGRPEKIR-HFREFLDSWRKFHDALHKNQKDVTDSFYPAM MONDO7_88_PE3 NOISO VASQVPFADLCSTLERIQKSKARPEKIK-YFKEFLDSWRRFHDALHKKEKEVTDSFYPAM MOUSE8_PE100 NOISO VAAHVPFADLCSTLERIQKGKDRAEKIR-HFKEFLDSWRKFHDALHKNRKDVTDSFYPAM NEMVE_3080_PE8 NOISO VASQVPFFNFCMAMERICEAKGSIEKKRDPLRKLISSWREAHRRIHGS-TKTTDSLFPLL OCHPRGS_4191_PE1 NOISO VASHVPFADLCSTLERIQRSKGRAEKIR-YFSEFLASWRKFHDALHKNQKDVTDSFYPAM ORYLA2_24_PE32 NOISO VAAQVPFSHLCTTLEKIQKAKLRPEKSK-ILGDFIGSWRNFHAALHKNNPRTADSFYPAM PANTR13_111_PE1 NOISO VASHVPFADLCSTLERIQKSKGRAEKIR-HFREFLDSWRKFHDALHKNHKDVTDSFYPAM PEDHC_895_PE28 NOISO LAKKISFGNFCQLCSKIKSADH-EKKII-ILRNYISNWKKKAKDIESDGLNLDDSFFPIF PIG11_78_PE2 NOISO VASHVPFADLCSTLERIQRSRGRGEKMR-HFKEFLDSWRKFHDALHKNHRDVTDSFYPAM POEGU1_36_PE9 NOISO VASHVPFSDLCSTLERIQKSKSRPEKTK-YFKDFLDSWRKFHDALHQKEKDVTDSFYPAM PONPY13RD_5_PE1 NOISO VASHVPFADLCSTLERIQKSKGRAEKIR-HFREFLDSWRKFHDAFHKNQKDVTDSFYPAM PTEVAGS_3160_PE1 NOISO VASHVPFADLCSTLERIQRSKGRAEKIR-YFREFLDSWRKFHDALHKNQKNVTDSFYPAM RABIT8_113_PE3 NOISO VASHVPFADLCSTLERIQRSKGRADKIR-HFSEFLDSWRKFHDALHKNQKDVTDSFYPAM RAT16_PE902 NOISO VAAHVPFADLCSTLERIQKGKDRAEKIR-HFKEFLDSWRKFHDALHKNKKDVPDSFYPAM SORAR229595_PE1 NOISO VASQVPFADLCSTLERIQKAKGRAEKVK-HYRDFLDSWRKFHDALHKNQKDVTDSFYPAM SPIPN_1_834 NOISO TASRASFYDLCRCLQSVLTKRGNDAKRE-RMKRYIEEWRAT-----------GGDFFPAL STRPU_5557_PE5 NOISO VASQIPFVQLCGFLERVQKKKGSDAKKL-LFKEFLEKWREFHKAMHAKNPNT-------- TARSY13215_PE1 NOISO VASHVPFADLCSTLERIQKGKGRAEKIR-YFREFLDSWRRFHDALHKNQKDVTDSFYPAM TETNG3_PE307 NOISO VAAQVPFLHLCTTLEKIQKAKARPDKSK-ILGDFIESWRNFHTALHKNS-KTTDSFYPAM THTRA1_1_9125 NOISO FASKVLFCNACLVFHKLSQTRKTKAKRQ-QLQALFERWGD-------------TRYFDIL TRIAD_735_PE506 NOISO VADEVPFFDLCTLLERISQASGKEKKKK-IYSDFLSSWRTAHFKLYGK-SSTEDSFFSAM TUPGBGS_4574_1_PE1 NOISO VASHVPFADLCSTLERIQKSKGRADKIR-HFREFLDSWRKFHDALHKNQKNVTDSFYPAM TURTRGS_2813_PE1 NOISO VASHVPFADLCSTLERIQRSKGRAEKIR-HFKEFLDSWRKFHDALHKNQKDVTDSFYPAM XENTR42_2_PE40 NOISO VASQVPFADLCCTLEKVQKCKNRTEKSH-IFKQFVDSWRKFHEALHKSQPKTTDSFYPAM MATCH CONSENSUS ?A??VPF??LC??LE?IQ????R??K???????F???WR?FH?A?H???????DSFYPAM

ACYPI_13021_PE4 NOISO RLLLPVSDKQRGAYGVKEAALGKLYVKILCLAKDSPDAQKLLNFRVPKVSG-ST-AGDFA AILMEGL192446_1_1_PE4 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRGGKDALKLLNYRTPTGTR-AD-AGDFA ANOCA3_12_PE8 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPKDGKDALKLLNYRTPTGSR-GD-AGDFA BOVIN12_84_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTR-GD-AGDFA CALJA1_24_PE3 ENSCJAG00000014689 RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-SGDFA CALJA1_24_PE4 ISOFORMIN RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-SGDFA CANFA22_61_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPKEGKDALKLLNYRTPTGTR-GD-AGDFA CAOWC1_1_4653 NOISO RLLLPSFDRERGMYGIKDAMLAKYYSDILGIVRGSEDYNKLKNYTKPQHNR-QS-AGDFA CAVPO5_18_PE4 NOISO RLILPQLERERMAYGIKETMLAKFYIELLNLPREGKDALKLLNYRTPTGTR-GD-AGDFA CHICK1_PE2311 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPKDGKDAVKLLNYRTPTGSR-GD-AGDFA CIOSAREFTIG_1_3_PE120 NOISO RLILPQLDKDRPSYGLKEVLLARLYVDVMGLSRTGKDAKKLLEFRNPKVNT-SS-AGDFA DANRE1_29_PE19 NOISO RLIVPSFERERMAYGIKENMLAKLYIEVLGLPKNGDEANKLLNYRAPTTSQ-GE-AGDFA ECHTE287220_PE1 NOISO RLILPQQERERMAYRIKETMLAKLYIELLNLPRGGKEALQLLNYRAPTGVR-GD-AGDFA FUGRU64_1_PE62 NOISO RLFVPQFERERMAYGIKESMLAKLYIDVLGLPKNGPEASKLLNYRAPNISQ-GD-AGDFA GASACGROUPI_22_PE33 NOISO RLIVPSFERDRVAYGIKENMLAKLYIDVLGLPKNGPEAHQLLNYRAPTTSQ-GE-AGDFA GORGO13_95_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA HORSE17_78_PE2 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTR-GD-TGDFA HS13_PE971 ENSG00000174405 RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA HS13_PE972 ISOFORMIN RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA HS13_PE973 ISOFORMIN RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA LOXAF29_29_PE2 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDALKLLNYRTPTGTR-GD-TGDFA MACMU17_91_PE2 ENSMMUG00000008874 RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA MACMU17_91_PE3 ISOFORMIN RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA MACMU17_91_PE4 ISOFORMIN RLILPQLERERMAYGIKETMLAKLY--------NGKDALKLLNYRTPTGTH-GD-AGDFA MICMUGS_3684_1_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDALKLLNYRTPTGTR-GD-AGDFA MONDO7_88_PE3 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPKEGKDAQKLLNYRTPTGTR-GD-AGDFA MOUSE8_PE100 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDAQKLLNYRTPSGAR-TD-AGDFA NEMVE_3080_PE8 NOISO RLLLPHLDKDRPAYGMKENIFARYIIDVMSLGKDSSSGRKLLNYRHPSSSK-QDSQGDFA OCHPRGS_4191_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPREGRDALKLLNYRAPTAAH-GD-AGDFA ORYLA2_24_PE32 NOISO RLIVPPFERERMAYGIKESMLAKLYIDVLGLPKNGPEANKLLNYRAPTTSQ-GE-AGDFA PANTR13_111_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA PEDHC_895_PE28 NOISO RLLIPHLDRERGAYGIKERTLAKIYISILSLPKDGEDALKLLNCKNPKTSY-FN-NCDFA PIG11_78_PE2 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTR-GD-AGDFA POEGU1_36_PE9 NOISO RLILPHLERERMAYGIKETMLAKLYIELLSLPKDGKDAARLLNYRTPTGSR-GD-AGDFA PONPY13RD_5_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTH-GD-AGDFA PTEVAGS_3160_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDALKLLNYRTPTGTR-GD-AGDFA RABIT8_113_PE3 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDALKLLNYRTPAATH-GD-AGDFA RAT16_PE902 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDAQKLLNYRTPSGAR-SD-AGDFA SORAR229595_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPKEGKDALKLLNYRTPTGTR-GD-AGDFA SPIPN_1_834 NOISO RLILPHLDKARTTYGMKDKVLAKTYVEVLGLSMNSPDAEGLINWRNPGKTG-KTMAGDFP STRPU_5557_PE5 NOISO ------------------HTLAKFYIDIFGLAKESTDAKKLLNYRAPTAKQ--------- TARSY13215_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPKEGKDALKLLNYRTPTGAR-GD-AGDFA TETNG3_PE307 NOISO RLLVPQFERERMAYGIKESMLAKLYIDVLGLPKNGPEANKLLNYRAPTTSQ-GE-AGDFA THTRA1_1_9125 NOISO RLMLPQMDKERATYGMKEANLGKLYVELLGVDASSAAAQSLIHWRIPTGLGAGADAGDFA TRIAD_735_PE506 NOISO RLLLPQMDKERLAYGMKETALAKYYIDILSISKESPAAQKLMNYRAPAAAK-QD-AGDFA TUPGBGS_4574_1_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTR-GD-AGDFA TURTRGS_2813_PE1 NOISO RLILPQLERERMAYGIKETMLAKLYIELLNLPRGGKDALKLLNYRTPTGTR-GD-AGDFA XENTR42_2_PE40 NOISO RLVVPQLERERMAYGIKETMLAKLYIKVLGLPKEGKDAIKLLNYRSPTSSH-SD-AGDFA MATCH :.: . * . * CONSENSUS RL?LP??ERER?AYGIKE?MLAKLYI??L?LP??G?DA?KLLNYR?P????????AGDFA

ACYPI_13021_PE4 NOISO ETLYW-VIRSRFEDN--GSMSIADINQILDEIAMKHATNESREVEQILQSMLLKLSANEQ AILMEGL192446_1_1_PE4 NOISO TIAYF-VLKPRCLQK--GSLTIQQVNDILDSIASNNSARRKDLIKKSLLQLISQSSALEQ ANOCA3_12_PE8 NOISO MIAYF-VLKPRCPKQ--GQLTIQQVNDLLDSVSTNNAAKRKDLVKKCLLQLITQSSALEQ BOVIN12_84_PE1 NOISO MIAYF-VLKPRCLQK--GSLSIQQVNDILDSIASNNSAKRKDLMKKSVLQLITQSSALEQ CALJA1_24_PE3 ENSCJAG00000014689 MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSVASNNSAKRKDLVKKSLLQLITQSSALEQ CALJA1_24_PE4 ISOFORMIN MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSVASNNSAKRKDLVKKSLLQLITQSSALEQ CANFA22_61_PE1 NOISO TIAYF-VLKPRCLQK--GSLTIQQVNDILDSIASNNSARKKDLIKKSLLQLITQSSALEQ CAOWC1_1_4653 NOISO MVAFF-VLQRRLADRPSNPLTVTDVNTLLDQLATEYMSNNRPGVKDTLRSMLFRSTAREQ CAVPO5_18_PE4 NOISO MIAYF-VLKPRCLQK--GSLNIQQVNELLDSIASNNSAKKKDLVKKSLLQLITQSSALEQ CHICK1_PE2311 NOISO MIAYF-VLKPRSPKR--GRLTVEQVNELLDAIANNNAAKNKGLVKKSLLQLITQSTALEQ CIOSAREFTIG_1_3_PE120 NOISO ETAYRQLLSKRCIDK--GSLTITQINTYLDKIATYNTEKKKDLVRKTLLEIIQKTSGIEQ DANRE1_29_PE19 NOISO LMAYF-VLKKRCTSQ--GNLSIKEVNDFLDSVAINNASKQKDQVKKSLLHLITQSSALEQ ECHTE287220_PE1 NOISO MIAYF-VLKPRSLPK--GSLTIQQVNDILDSVASNNSAQKKNLVKSSLLRFITQSSALEQ FUGRU64_1_PE62 NOISO SVAYF-VLKKRCTSQ--GNLSVQEVNDFLDSVAINNASKKKDLVKKSLLHLITQSSALEQ GASACGROUPI_22_PE33 NOISO GMAYF-VLKKRCASP--GTLSIKEVNDFLDSVAINNAGKQKDLVKKSLLHLITHSSALEQ GORGO13_95_PE1 NOISO MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQ HORSE17_78_PE2 NOISO TIAYF-VLKPRSLPK--GSLTIQQVNDILDSVASNNSAKRKDLIKKSLLQLITQSSALEQ HS13_PE971 ENSG00000174405 MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQ HS13_PE972 ISOFORMIN MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQ HS13_PE973 ISOFORMIN MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQ LOXAF29_29_PE2 NOISO MIAYF-VLKPRCLQK--GSLTIQQVNDILDSVASNNSAKKKNLVKKSLLQFIAQSSALEQ MACMU17_91_PE2 ENSMMUG00000008874 LIAYF-VLK-----K--GSLTIQQVNDLLDSVASNNSAKRKDLIKKSLLQLITQSSALEQ MACMU17_91_PE3 ISOFORMIN LIAYF-VLKPRCLQK--GSLTIQQVNDLLDSVASNNSAKRKDLIKKSLLQLITQSSALEQ MACMU17_91_PE4 ISOFORMIN LIAYF-VLKPRCLQK--GSLTIQQVNDLLDSVASNNSAKRKDLIKKSLLQLITQSSALEQ MICMUGS_3684_1_PE1 NOISO MIAYF-VLRPRCLKK--GSLTIQQVNDLLDSVASNNSAKRKDLIKKSLLQLITQSSALEQ MONDO7_88_PE3 NOISO MIAYF-VLKPRCPKQ--GSLTIQQVNDILDLIASNNSANRKDLVKKNLLQLITQSSALEQ MOUSE8_PE100 NOISO MIAYF-VLKPRCLQK--GSLTIQQVNELLDLVASNNSGKKKDLVKKSLLQLITQSSALEQ NEMVE_3080_PE8 NOISO SVAYF-VLKDRCPEK--GSLNIEEVNKLLDDMANANLEKKRDNVKMSIQMLLRESSAKEV OCHPRGS_4191_PE1 NOISO MTAYF-VLKPRCSQK--GSLSVQQVNELLDSVASSNAARRKDLIKKSLLQLIVQSSALEQ ORYLA2_24_PE32 NOISO GMAYF-VLKKRCTSQ--GNLSIKEVNDFLDSVALNNASKKKDLMRKSLLHLITQSSALEQ PANTR13_111_PE1 NOISO MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQ PEDHC_895_PE28 NOISO SIAFC-ILRNRCAEG--GQLSVEEVNKHLDKISTSHAANEPRNVDAELISLLKSTNAEEQ PIG11_78_PE2 NOISO IIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIASNNSAKRKDLVKKSLLQLITQSSALEQ POEGU1_36_PE9 NOISO MIAYF-VLKPRSPKQ--GRLTIEQVNEHLDAIANNNAAKNKGQLKKSLLQLITQSTALEQ PONPY13RD_5_PE1 NOISO MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQ PTEVAGS_3160_PE1 NOISO MIAYF-VLKPRCLQK--GSLSIQQVNDILDSVASNNSSKRKDLIKKSLLQFITQSSALEQ RABIT8_113_PE3 NOISO MTAYF-VLKPRCLQK--GSLTIQQVNDLLDSVASNNSAKRKDLTKKSLLQLITQSSALEQ RAT16_PE902 NOISO TIAYF-VLKPRCLQK--GSLTIQKVNELLDLVASNNSGKRKDLVKKSLLQLITQCSALEQ SORAR229595_PE1 NOISO MIAYF-VLKPRCLQK--GSLTIQEVNSILDSIASNNSSKRKDLMKKSLLQFIAQSSALEQ SPIPN_1_834 NOISO GVLHQ-VIAGRSNVLGRSNVTVADINDKLDWLNVT---DDRGERRDIIRYFFLNCTPMEQ STRPU_5557_PE5 NOISO ------------------------------------------------------------ TARSY13215_PE1 NOISO IIAYF-VLKPRCLQK--GSLTIQQVNDLLDSVASSNSAKRKDQVKKSLLQLITQSSALEQ TETNG3_PE307 NOISO SVAYF-VLKKRCTSQ--GSLRVKEVNDFLDSVAINNANKKKDLVKKSLLHLITHSSALEQ THTRA1_1_9125 NOISO EVAER-VLRSRCHDK--PTLSIKQVNDALDALARAV---ERSARLEILRSLQRQTTAVEQ TRIAD_735_PE506 NOISO SVAFF-VLRTRCPEK--GTLSIADVNECLDNIAMANSQRKRDDVRNNLRKLLRNTCAMEQ TUPGBGS_4574_1_PE1 NOISO MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSVASNNSAKRKDLIKKSLLQLITQSSALEQ TURTRGS_2813_PE1 NOISO MIAYF-VLKPRCLQK--GSLTIQQVNDLLDSIANNNSAQRKDLVKKSLLQLITQSSALEQ XENTR42_2_PE40 NOISO AIAYF-VLKSRCRKE--GSLSIQEVNYHLDSIANNNAAKKKELIEKSLLHLIANTTALEQ MATCH CONSENSUS ??AYF?VLK?RC?????G?L?I??VN??LD??A??N????K???KK?LL?LI??SSALEQ

ACYPI_13021_PE4 NOISO KWLIRLLLKDMRLGIAHTKILKAYHDDANDLYDVCNDLKKVCKMLNNPSVVL---HEISV AILMEGL192446_1_1_PE4 NOISO KWLIRMIVKDLKLGFSEQSVFSVFHNDAAELHNVTTDLEKVCRQLHDPSIGL---SDISI ANOCA3_12_PE8 NOISO KWLIRMIIKDLKLGVSQQTIFSIFHPDATELHNVTTDLEKVCRQLHHPSVFL---SDVSI BOVIN12_84_PE1 NOISO KWLIRMIVKDLKLGFSQQTIFSIFHSDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI CALJA1_24_PE3 ENSCJAG00000014689 KWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI CALJA1_24_PE4 ISOFORMIN KWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI CANFA22_61_PE1 NOISO KWLIRMIVKDLKLGFSEQSVFSAFHNDAAELHNVTTDLEKVCRQLHDPSIGL---SDISI CAOWC1_1_4653 NOISO KWLIRIIGKDVKCGMSAQTVLKTFHQDAVDLFNVCSNLRRVCWQLRDPTKRL---VSNDV CAVPO5_18_PE4 NOISO KWLIRMIVKDLKLGFSEKTILSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI CHICK1_PE2311 NOISO KWLIRMIIKDLKLGVSQQTIFSIFHPDAAELHNVTTDLEKVCRQLHDPSVSL---SDVSI CIOSAREFTIG_1_3_PE120 NOISO KWLIRIILKDTKLRMGHKVILQEIHPDAEELFNVTTSLKQVCRQLNDPDVRL---ADTEI DANRE1_29_PE19 NOISO KWLIRMILKDMKLGISKETVLQVFHPDAPEFYNVTTDLNKVCRQLHDPSVSL---SEVSI ECHTE287220_PE1 NOISO KWFIRMILKDLHLGVSESTIFSVFHRDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI FUGRU64_1_PE62 NOISO KWLVRMILKDMKLGVSKETVLQVFHPDAPDLYNVNTDLNKVCQQLHDPSVSL---SEVSI GASACGROUPI_22_PE33 NOISO KWLIRMILKDMKLGISKETVLQVFHPDAADFYNVNTDLNKVCQQLHSPSVSL---SEVSI GORGO13_95_PE1 NOISO KWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI HORSE17_78_PE2 NOISO KWLIRMIVKDLKLGVSEQTVFSAFHNDAAELHNVTTDLEKVCRQLHDPLIGL---SDISI HS13_PE971 ENSG00000174405 KWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI HS13_PE972 ISOFORMIN KWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI HS13_PE973 ISOFORMIN KWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI LOXAF29_29_PE2 NOISO KWLIRMILKDLKLGVSQQVVFSLFHDDAAELYSVTTDMEKVCRQLHDPSVGL---SDISI MACMU17_91_PE2 ENSMMUG00000008874 KWLIRMIIKDLKLGVSQQTIFSVFHNDAVELHNVTTDLEKVCRQLHDPSVGL---SDISI MACMU17_91_PE3 ISOFORMIN KWLIRMIIKDLKLGVSQQTIFSVFHNDAVELHNVTTDLEKVCRQLHDPSVGL---SDISI MACMU17_91_PE4 ISOFORMIN KWLIRMIIKDLKLGVSQQTIFSVFHNDAVELHNVTTDLEKVCRQLHDPSVGL---SDISI MICMUGS_3684_1_PE1 NOISO KWLIRMIIKDLKLGVSQQTILSVFHNDAVELHGVTTDLEKVCRQLHDPSVGL---SDISI MONDO7_88_PE3 NOISO KWLIRMIIKDLKLGFSQQTIFSLFHRDAAELHNVTTDLEKVCRQLHNPLVGL---SDISI MOUSE8_PE100 NOISO KWLIRMIIKDLKLGISQQTIFSIFHNDAVELHNVTTDLEKVCRQLHDPSVGL---SDISI NEMVE_3080_PE8 NOISO KWLIRIILKELKMGLGENSVFAVFHPDALDHYNTCNNLSKVCMDLHDPSVRM---NEAEI OCHPRGS_4191_PE1 NOISO KWLIRMIVKDLKLGVSQQTILNAFHTDAVELHNVTTDLERVCRQLHDPSVGL---TDISI ORYLA2_24_PE32 NOISO KWLIRMILKDMKLGISKETVLQAFHPDAAELYNVNTDLNKVCQQLHNPSVSL---SDVSI PANTR13_111_PE1 NOISO KWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI PEDHC_895_PE28 NOISO KWLIRILLKDVKLGLSENVIFKCYHPDARELYDSSNSLRKICDLLNDPEIRL---NEIQI PIG11_78_PE2 NOISO KWLIRMILKDLKLGFSQQTIFSLFHDDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI POEGU1_36_PE9 NOISO KWLIRMIIKDLKLGVSQQTIFSVFHPDAVELHNVTTDLEKVCRQLHDPSVSL---SDVSI PONPY13RD_5_PE1 NOISO KWLIRMIIKDLKLGVSQQTIFSVFHSDAVELHNVTTDLEKVCRQLHDPSVGL---SDISI PTEVAGS_3160_PE1 NOISO KWLIRMIIKDLRLGFSEQTVFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI RABIT8_113_PE3 NOISO KWLIRMIVKDLKLGVSQQTIFSAFHADAVELHNVTTDLEKVCRQLHNPSVGL---SDISI RAT16_PE902 NOISO KWLIRMIIKDLKLGVSQHTILSIFHNDAVELHNVTTDLEKVCRQLHDPSVGL---SDISI SORAR229595_PE1 NOISO KWLIRMIVKDLKLGISHQTILSVFHSDAVELHGVTTDLEKVCRQLHDPSVGL---SDISI SPIPN_1_834 NOISO MWIARMILKDLKLGISENTVLGLWHPDALEHFNVTSDLAKVTHDLPDPKLSL---TNKEI STRPU_5557_PE5 NOISO ---------EMKVGLSQQSILGTFHPDAEDLFNVTNSLSKVCSDLSSPSVRL---NEIAI TARSY13215_PE1 NOISO KWLIRMIVKDLKLGVSQQTIFSVFHSDATELHNVTTDLEKVCRQLHDPSVGL---SDISI TETNG3_PE307 NOISO KWLIRMILKDMKLGVSKETVLQVFHPDSPDLYNVNTDLNKVCQQLHDPSVSL---SDVSI THTRA1_1_9125 NOISO KWIIRIILKDMKMHVSETTVLKYFHPDALEAYNVCSSLKQVALEFADRNVRPVASSAAAI TRIAD_735_PE506 NOISO KWLIRMIMKELKVGLSENSIFSVFHPDASDLFNVSSSLSKVCSDLMDPDVRL---NETSI TUPGBGS_4574_1_PE1 NOISO KWLIRMIVKDLKLGVSQQTIFSAFHNDAAELHNVTTDLEKVCRQLHDPTVGL---SDISI TURTRGS_2813_PE1 NOISO KWLIRMIVKDLKLGFTQQTVFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGL---SDISI XENTR42_2_PE40 NOISO KWLIRMIIKDMKLGFSQQTVFSIFHPDAAELHNVTTDLEKVCIQLHDPNVCL---SDVSI MATCH : : . :: * *: : .. ..: :: : : CONSENSUS KWLIRMI?KD?KLG?S??T????FH?DA?EL?NV?TDL?KVC?QLHDP?V?L???S??SI

ACYPI_13021_PE4 NOISO NLFEPFCPMLSQRCEITDDSKINKMVKN-EDLFVDIKLDGERFQLHWSKEKNIFKYFSRR AILMEGL192446_1_1_PE4 NOISO TLFSAFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--RQGDVYQYFSRN ANOCA3_12_PE8 NOISO TLFSAFKPMLAAIANIQ---QIEKQMNN-QSFYIETKLDGERMQMH--KDGDVYKYFSRN BOVIN12_84_PE1 NOISO TLFSAFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYRYFSRN CALJA1_24_PE3 ENSCJAG00000014689 TLFSAFKPMLAAIADIE---HIEKDMKH-QTFYIETKLDGERMQMH--KDGDVYKYFSRN CALJA1_24_PE4 ISOFORMIN TLFSAFKPMLAAIADIE---HIEKDMKH-QTFYIETKLDGERMQMH--KDGDVYKYFSRN CANFA22_61_PE1 NOISO TLFSAFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYQYFSRN CAOWC1_1_4653 NOISO SLFHPFRPMLAMRENIS---KIADKLG---TFFMEIKFDGDRVMMH--KQGDKYQYWSRK CAVPO5_18_PE4 NOISO TLFSAFKPMLAAIANIE---HIEKDMKQ-QSFYIETKLDGERMQMH--KDGDVYRYFSRN CHICK1_PE2311 NOISO MLFSAFKPMLAAIADVQ---QIEKQMNN-QVFYIETKLDGERMQMH--KDGDVYKYFSRN CIOSAREFTIG_1_3_PE120 NOISO KLFQPFRPMLALNAAIN---EVDKLMEN-KPFNIEIKYDGERSQMH--KEGNCYKYFSRS DANRE1_29_PE19 NOISO DLFSAFKPMLAAVANIR---QIEKQMGN-RPFYIETKLDGERIQLH--KAGDVYKYYTRN ECHTE287220_PE1 NOISO TLFSPFKPMLAAIADIQ---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDEYKFFSRN FUGRU64_1_PE62 NOISO ELFSAFKPMLAAVANIH---TVEKQMGN-SPFYIQTKLDGERIQLH--KDGDVYKYFSRN GASACGROUPI_22_PE33 NOISO GLFSAFKPMLAAVANIR---NVEKQMGN-GPFYIQTKLDGERIQLH--KDGDVYKYFSRN GORGO13_95_PE1 NOISO TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN HORSE17_78_PE2 NOISO TLFSAFKPMLAAIANIE---RIEKDMKH-QSFYIETKLDGERMQMH--KHGDVYQYFSRN HS13_PE971 ENSG00000174405 TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN HS13_PE972 ISOFORMIN TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN HS13_PE973 ISOFORMIN TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN LOXAF29_29_PE2 NOISO TLFSAFRPMLAAIADIR---HVERDMKH-QSFYIETKLDGERMQMH--RDGDVYKFFSRN MACMU17_91_PE2 ENSMMUG00000008874 TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN MACMU17_91_PE3 ISOFORMIN TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN MACMU17_91_PE4 ISOFORMIN TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN MICMUGS_3684_1_PE1 NOISO TLFSAFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGTDYKYFSRN MONDO7_88_PE3 NOISO TLFSAFKPMLAAVADIQ---RIEKDMKH-QGFYIETKLDGERMQMH--KDGDVYKFFSRN MOUSE8_PE100 NOISO TLFSAFKPMLAAVADVE---RVEKDMKQ-QSFYIETKLDGERMQMH--KDGALYRYFSRN NEMVE_3080_PE8 NOISO TIFSAFRPMLAQWSPLN---QVEDLMKN-QPFYIETKMDGERFILH--KDGDKYRYFSRG OCHPRGS_4191_PE1 NOISO TLFSAFKPMLAAVADVE---RIEKDMKQ-QSFYIETKLDGERMQMH--KDGDVYRYFSRN ORYLA2_24_PE32 NOISO GLFSAFKPMLAAVANIR---NVEKQMGN-SPFYIETKLDGERIQLH--KDGDVYKYFSRN PANTR13_111_PE1 NOISO TLFSAFKPMLAAIANIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN PEDHC_895_PE28 NOISO QLFTPFKPMLSEECDIQ---KIDYYLKRSCHFFIETKLDGERFQLH--FEEGNFKYFSRN PIG11_78_PE2 NOISO TLFSAFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYQYFSRN POEGU1_36_PE9 NOISO MLFSAFKPMLAAIADVQ---QIEKQMSN-QTFYIETKLDGERMQMH--KDGDVYKYFSRN PONPY13RD_5_PE1 NOISO TLFSAFKPMLAAIADIE---HIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN PTEVAGS_3160_PE1 NOISO TLFSAFKPMLAAIADIE---RIEKDMKN-QSFYIETKLDGERMQMH--KDGDIYEYFSRN RABIT8_113_PE3 NOISO TLFSAFKPMLAAVADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYQYFSRN RAT16_PE902 NOISO TLFSAFRPMLAAVADVE---RVEKDMKQ-QSFYIETKLDGERMQMH--KDGALYRYFSRN SORAR229595_PE1 NOISO SLFSPFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQLH--KDGDVYEYFSRN SPIPN_1_834 NOISO RINGVFKPMKAKSVEN--PHDIPRIIGN-TTFWVETKLDGERIQMH--LQGGKFKWWSRN STRPU_5557_PE5 NOISO SVFSPFSPMLGERAKIT---GVERMMEH-KGFLIETKLDGERMQLH--KEGDKYMYFSRR TARSY13215_PE1 NOISO TLFSAFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN TETNG3_PE307 NOISO ELFSAFKPMLAAVANIR---SVEKQMGN-SLFYIQTKLDGERIQLH--KDGDVYKYFSRN THTRA1_1_9125 NOISO TLFKPIKPMLAVRCNTVE--KALEEMGS-APWVIETKYDGERLQVH--YSKDRIALFSRS TRIAD_735_PE506 NOISO ELFVPFRPMLAERCPLQ---QVEKLMNH-EMFYIECKADGDRMQLH--KDGNKYMYFSRS TUPGBGS_4574_1_PE1 NOISO TLFSAFKPMLAAIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYQYFSRN TURTRGS_2813_PE1 NOISO TLFSAFKPMLASIADIE---RIEKDMKH-QSFYIETKLDGERMQMH--KDGDVYRYFSRN XENTR42_2_PE40 NOISO SMFSAFKPMLAAIANIQ---NIEKQMNH-QSFYIETKLDGERMQMH--KDGDVYKYFSRN MATCH : : ** . : :: * **:* :* ::* CONSENSUS ?LFS?FKPMLA??A?I??????EK?M?????FYIETKLDGER?Q?H??K?GD?Y?YFSRN

ACYPI_13021_PE4 NOISO GNDYTDTYGCNDVNGILSPVLAKQFKSDVKNCILDGEMMCYNTKYKSFSTKGN------- AILMEGL192446_1_1_PE4 NOISO GYNYTDQFGDSPREGSLTPFIHSAFKTDVQICILDGEMMAFNPNTQTFMQKGNKFDIKRM ANOCA3_12_PE8 NOISO GFDYTQQFGASPLEGSLTPFIHNVFENNVQNCILDGEMMAYNPITQTFMQKGNKFDIKRM BOVIN12_84_PE1 NOISO GYNYVDQFGASPQEGSLTPFIHNAFKTEVLNCILDGEMMAYNPNTQTFMQKGNKFDIKRM CALJA1_24_PE3 ENSCJAG00000014689 GYNYTDQFGASPTEGSLTPFIHNAFQTDIHICILDGEMMAYNPNTQTFMQKGIKFDIKRM CALJA1_24_PE4 ISOFORMIN GYNYTDQFGASPTEGSLTPFIHNAFQTDIHICILDGEMMAYNPNTQTFMQKGIKFDIKRM CANFA22_61_PE1 NOISO GYNYTDQFGDSPREGSLTPFIHSAFKTDVQICILDGEMMAFNPNTQTFMQKGNKFDIKRM CAOWC1_1_4653 NOISO SINYSDKYGFSPDCGTITQYVHNAFKPGVTDVILDGEMILYDTKLDCFVPKSS-ADVKSF CAVPO5_18_PE4 NOISO GYNYTDQFGASPNEGSLTPFIHKAFKTDVQTCILDGEMMAYNPNTQTFMQKGNKFDIKRM CHICK1_PE2311 NOISO GFDYTQQFGASPVDGSLTPFIHNVFKSDIQNCILDGEMMAYNPETQTFMQKGNKFDIKRM CIOSAREFTIG_1_3_PE120 NOISO GKEYSTVFGETPYIGTLTPFIHNCFDDSVHSCILDGEMMGFDPQLNIFMQKGGKFDIKHV DANRE1_29_PE19 NOISO SYEYTQQFGASPLEGSLTPYIHNVFSPHVVNCILDGEMMAYNPKTETFMQKGSKFDIKRL ECHTE287220_PE1 NOISO GYNFTKEFGDSSQNGSLTPFIHSAFKTDIQNCILDGEMMAYNPNTQSFMQKGMKFDIKRM FUGRU64_1_PE62 NOISO AFEYTQQFGGSPLQGSLTPYIHNVFNSHVVNCILDGEMMAYNPTTETLTQKGSKFDIKRL GASACGROUPI_22_PE33 NOISO AFEYTQQFGGSPLQGSLTPHIHNAFKGHVVNCILDGEMMAYNPTAETFMQKGSKFDIKRL GORGO13_95_PE1 NOISO GYNYTDQFGASPTEGSLTPFIHNAFKTDIQICILDGEMMAYNPNTQTFMQKGTKFDIKRM HORSE17_78_PE2 NOISO GYDYTDQFGDSPQEGSLTPFIHNAFQPDIQICILDGEMMAYNPNTQTFMQKGNKFDIKRM HS13_PE971 ENSG00000174405 GYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRM HS13_PE972 ISOFORMIN GYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRM HS13_PE973 ISOFORMIN GYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRM LOXAF29_29_PE2 NOISO GYDYTDQFGDSSQQGSLTPFIHGAFQTNTQNCILDGEMMAYDPNTQSFMQKGNKFDIKRM MACMU17_91_PE2 ENSMMUG00000008874 GYNYTDQFGASPTEGSLTPFIHNAFKTDIQICILDGEMMAYNPNTQTFMQKGIKFDIKRM MACMU17_91_PE3 ISOFORMIN GYNYT---------GSLTPFIHNAFKTDIQICILDGEMMAYNPNTQTFMQKGIKFDIKRM MACMU17_91_PE4 ISOFORMIN GYNYTDQFGASPTEGSLTPFIHNAFKTDIQICILDGEMMAYNPNTQTFMQKGIKFDIKRM MICMUGS_3684_1_PE1 NOISO GYNYTDQFGASPDEGSLSPFIHNAFKTDIEVCILDGEMMAYNPNTQTFMQKGIKFDIKRM MONDO7_88_PE3 NOISO GYDYTEQFGDSSLNGSLIPFIHKAFKTNIQNCILDGEMMAYNPNTQTFMQKGSKFDIKRM MOUSE8_PE100 NOISO GYNYTDQFGESPQEGSLTPFIHNAFGTDVQACILDGEMMAYNPTTQTFMQKGVKFDIKRM NEMVE_3080_PE8 NOISO GNDFTHTFGENSREGCLTPKINDCFERLISISSPGQSIHAFWMERCWFMTHPMKFL---- OCHPRGS_4191_PE1 NOISO GYNYTEQFGASPQEGSLSPFVHSAFRADAQVCILDGEMMAYSPHTQTFMQKGNKFDIKRM ORYLA2_24_PE32 NOISO AFEYTQQFGGSPLEGSLTPYIHNVFKSHVANCILDGEMMAYNPTTETFMQKGSRFDIKKL PANTR13_111_PE1 NOISO GYNYTDQFGASSTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRM PEDHC_895_PE28 NOISO GYDFTTNFGSSKREGNLSPRIFKRIPPHVKSFVLDGEMMSWDRITRSFSSKGKNLDVKNL PIG11_78_PE2 NOISO GYNYGDQFGVSPQEGSLTPFIHGTFKTNVQNCILDGEMMAYNPNTQTFMQKGNKFDIKRM POEGU1_36_PE9 NOISO GFDYTQQFGASPLEGSLTPFIHNVFKSNIQNCILDGEMMAYNPEAQSFMQKGNKFDIKRM PONPY13RD_5_PE1 NOISO GYNYTDQFGASPTEGSLTPFIHNAFKTDIQICILDGEMMAYNPNTQTFMQKGTKFDIKRM PTEVAGS_3160_PE1 NOISO GYKYTEQFGASPQEGSLTPFVHNAFKTDIQVCILDGEMMAYNPNTQTFMQKGNKFDIKRM RABIT8_113_PE3 NOISO GYNYTDQFGAAPHEGSLTPFIHSAFKTESQSCILDGEMMAYSPDTQTFMQKGNKFDIKRM RAT16_PE902 NOISO GYNYTDQFGESPQEGSLTPFIHNAFKTDVQVCILDGEMMAYNPTTQTFMQKGVKFDIKRM SORAR229595_PE1 NOISO GYNYTSQFGASPQEGSLTPFIHSAFRADVRVCILDGEMMAYNPNTQTFMQKGSKFDIKRM SPIPN_1_834 NOISO ATPYTSMYGADPSHGSLVPYIYEQFDPKVHSVILDGELLAFNTESGLYEAFGSLKTASNE STRPU_5557_PE5 NOISO SHDYSGSFGKSPMEGSLTPYIANCFNRDVHSCILDGEMCAYNSETKAFISKGENFDIKSL TARSY13215_PE1 NOISO GYNYTDQFGAFPDEGSLTPFIHNTFNIDIQSCILDGEMMAYNPDTQTFMQKGNKFDIKRM TETNG3_PE307 NOISO AFEYTQQFGGSPLQGSLTPYIHNVFQSNVVNCILDGEMMAYNPTTETLTQKGSKFDIKKL THTRA1_1_9125 NOISO GKDYTREYLA-----SVQPLLEKAIPSSVHTLILDGELVVWNETKQNYSVFGNLKTIARR TRIAD_735_PE506 NOISO SKEYTSSFGATPDEGSFTPFIVNVFSSQVQSAILDGEMVGYDMENDCYVPRGENIDVKAV TUPGBGS_4574_1_PE1 NOISO GYDYTDQFGASPCEGSLTPFIHNAFKTDIQNCILDGEMMAYNPETQTFMQKGNKFDIKRM TURTRGS_2813_PE1 NOISO GYNYEDQFGSSPQEGSLTPFIHNAFKTDVQNCILDGEMMAYNPDTQTFMQKGSKFDIKRM XENTR42_2_PE40 NOISO GFDYTQQFGASPLEGSLTPYIHNAFSLNIQNCILDGEMMAYNPNTQTFMQKGNKFDIKRM MATCH . : . : : . .: : CONSENSUS G??YT??FG?SP??GSLTP?IH??F??????CILDGEMMAYNP?T??FMQKG?KFDIK??

ACYPI_13021_PE4 NOISO ---------------------------------------------THQPCFCVFDIVYYN AILMEGL192446_1_1_PE4 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN ANOCA3_12_PE8 NOISO VDD----------------------------------------S-ELQTCFCVFDVLMIN BOVIN12_84_PE1 NOISO VED----------------------------------------S-ELQTCYCVFDVLMVN CALJA1_24_PE3 ENSCJAG00000014689 VED----------------------------------------S-DLQTCYCVFDVLMVN CALJA1_24_PE4 ISOFORMIN VED----------------------------------------S-DLQTCYCVFDVLMVN CANFA22_61_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN CAOWC1_1_4653 NOISO AGT----------------------------------------D-EQRPCYVVFDIVFLN CAVPO5_18_PE4 NOISO VEE----------------------------------------S-DLQTCYCVFDVLMVN CHICK1_PE2311 NOISO VED----------------------------------------S-DLQTCFCVFDVLMIN CIOSAREFTIG_1_3_PE120 NOISO TED----------------------------------------S-DLQPCFVVFDILYLN DANRE1_29_PE19 NOISO VDD----------------------------------------S-DLQTCFCVFDVLLIN ECHTE287220_PE1 NOISO VED----------------------------------------S-DLQTCYCAFDVLMVN FUGRU64_1_PE62 NOISO MDD----------------------------------------S-ELQTCFCVFDVLLVN GASACGROUPI_22_PE33 NOISO MED----------------------------------------S-ELQTCFCVFDVLLVN GORGO13_95_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN HORSE17_78_PE2 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN HS13_PE971 ENSG00000174405 VED----------------------------------------S-DLQTCYCVFDVLMVN HS13_PE972 ISOFORMIN VED----------------------------------------S-DLQTCYCVFDVLMVN HS13_PE973 ISOFORMIN VED----------------------------------------S-DLQTCYCVFDVLMVN LOXAF29_29_PE2 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN MACMU17_91_PE2 ENSMMUG00000008874 VED----------------------------------------S-DLQTCYCVFDVLMVN MACMU17_91_PE3 ISOFORMIN VED----------------------------------------S-DLQTCYCVFDVLMVN MACMU17_91_PE4 ISOFORMIN VED----------------------------------------S-DLQTCYCVFDVLMVN MICMUGS_3684_1_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN MONDO7_88_PE3 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN MOUSE8_PE100 NOISO VED----------------------------------------S-GLQTCYSVFDVLMVN NEMVE_3080_PE8 NOISO ---------------------------------------------FRQPCFVVFDVLLYN OCHPRGS_4191_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN ORYLA2_24_PE32 NOISO MDD----------------------------------------S-ELQTCFCVFDVLLVN PANTR13_111_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN PEDHC_895_PE28 NOISO KEG----------------------------------------N-HYQSCFCVFDILLYN PIG11_78_PE2 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN POEGU1_36_PE9 NOISO VED----------------------------------------S-DLQTCFCVFDVLMVN PONPY13RD_5_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN PTEVAGS_3160_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN RABIT8_113_PE3 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN RAT16_PE902 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN SORAR229595_PE1 NOISO VDE----------------------------------------S-DLQTCFCVFDILMVN SPIPN_1_834 NOISO RWE----------------------------------------H-YVGNRQNVFDIVYLN STRPU_5557_PE5 NOISO RDE----------------------------------------E-DVQVCYAVFDVLLVN TARSY13215_PE1 NOISO VED----------------------------------------S-DLQTCYCVFDVLMVN TETNG3_PE307 NOISO MDD----------------------------------------S-ELQTCFCVFDVLLVN THTRA1_1_9125 NOISO DLEKKIENDRANGCVDPEQLAALDAMRSSRHSRGPSGNLQADPGDKQSVFYVVFDLLLFN TRIAD_735_PE506 NOISO GRT----------------------------------------SAIIQQCYMVFDILMLN TUPGBGS_4574_1_PE1 NOISO VED----------------------------------------S-ELQTCYCVFDVLMVN TURTRGS_2813_PE1 NOISO VED----------------------------------------S-DLHTCYCVFDVLMVN XENTR42_2_PE40 NOISO VDD----------------------------------------S-ELQTCYCVFDVLLLN MATCH .**:: * CONSENSUS ???????????????????????????????????????????S??LQTC?CVFDVL??N

ACYPI_13021_PE4 NOISO DRVITNLPLEKRLDILNTIF--EPLEGIFVHTTRH-KARKNELMKYLNDAIDNHEEGIVV AILMEGL192446_1_1_PE4 NOISO NKKLGRETLKKRHEILTSVF--TPIPGRIEIVQKTQAHTQKEVIDALNEAIDKREEGIMI ANOCA3_12_PE8 NOISO DQKLGHEILSKRYEVLNKIF--TPIPGRIQVVSKTQANTRKEVVDALNEAIDNREEGIVV BOVIN12_84_PE1 NOISO DKKLGHETLRKRYEILNSVF--TPVPGRIEIVQKTQAHTKKEVIDALNEAIDKREEGIMV CALJA1_24_PE3 ENSCJAG00000014689 NKKLGHETLRKRYEILNSIF--TPIPGRIEVVQKTQAHTKDEVIDALNEAIDKREEGIMI CALJA1_24_PE4 ISOFORMIN NKKLGHETLRKRYEILNSIF--TPIPGRIEVVQKTQAHTKDEVIDALNEAIDKREEGIMI CANFA22_61_PE1 NOISO NKKLGRETLKKRYEILTSVF--TPIPGRIEIVQKTQAHTKKEVIDALNEAIDKREEGIMI CAOWC1_1_4653 NOISO GTSLCNMPLIERLRTLRKVF--TPITGRIMFADQRTGTTSQEIIDFLNEAIDNREEGVMV CAVPO5_18_PE4 NOISO NKKLGRETLKKRHEILNNTF--TPIPGRMEIVQKAQARTKKEVIDALNEAIDKREEGIMV CHICK1_PE2311 NOISO DQKLAHESLSTRYKILSNVF--TPLTGRIHVVHKKSARTRKEVIDALNEAIDNREEGIMV CIOSAREFTIG_1_3_PE120 NOISO DELLTSKPQIERFNLFNKLI--VPVEGRMHLTEAKQASSNKEVVASLNEAIDRREEGIIV DANRE1_29_PE19 NOISO NQKFGKEPLKKRYESLETVF--SPIKGRIHLVSKSEGRTMQEVVNSLNEAIDNREEGIMV ECHTE287220_PE1 NOISO NKKLGHEILKKRYEILSSIL--SPIPGRIEIVQKTEAHTKKEVIDALNEAIDKREEGIMI FUGRU64_1_PE62 NOISO DQKLGKEPLKKRYETLQTVF--TPVKGRIHLVSKTDARRMQEVVNALNEAIDNREEGIMV GASACGROUPI_22_PE33 NOISO DRKLGRETLKQRHETLQTVF--TPVKGRLHLVPKADARTMHEVVNALNDAIDGREEGIMV GORGO13_95_PE1 NOISO NKKLGHETLRKRYEILSSIF--TPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMV HORSE17_78_PE2 NOISO NKKLGRETLRKRCEILSSIF--MPIPGRIEIVQKMQAHTKQEVIDALNEAIDKREEGIMI HS13_PE971 ENSG00000174405 NKKLGHETLRKRYEILSSIF--TPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMV HS13_PE972 ISOFORMIN NKKLGHETLRKRYEILSSIF--TPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMV HS13_PE973 ISOFORMIN NKKLGHETLRKRYEILSSIF--TPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMV LOXAF29_29_PE2 NOISO NKKLGHETLRKRYEILSGIF--TPIPGRIEIVQKTQAHTKKEVIDALNEAIDKREEGIMI MACMU17_91_PE2 ENSMMUG00000008874 NKKLGHETLRKRYEILSSIF--TQIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMI MACMU17_91_PE3 ISOFORMIN NKKLGHETLRKRYEILSSIF--TQIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMI MACMU17_91_PE4 ISOFORMIN NKKLGHETLRKRYEILSSIF--TQIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMI MICMUGS_3684_1_PE1 NOISO NKKLGHETLKKRYEILSSIF--TPIPGRIEIVQKIQAHTKNEVIDALNEAIDKREEGIMI MONDO7_88_PE3 NOISO NKKLGHEALRKRYEIISTVF--TPIKGRLEVVQKTEANTKKEVIDALNEAIDKREEGIMI MOUSE8_PE100 NOISO KKKLGRETLRKRYEILSSTF--TPIQGRIEIVQKTQAHTKKEVVDALNDAIDKREEGIMV NEMVE_3080_PE8 NOISO GKKLANTPLHERLKLLETVF--KPCLGFLQFVERQNASSNEEVIKSLNEAIDRREEGLVV OCHPRGS_4191_PE1 NOISO NKKLGRETLRNRYEILSSLF--TPIPGRIEIVHKALAHTKNEVIDALNEAIDKREEGIMI ORYLA2_24_PE32 NOISO DQKLGKEALRKRHEILQTVF--TPAKGRMHLVPKSEARSVQEVVSALNDAIDSREEGIMV PANTR13_111_PE1 NOISO NKKLGHETLRKRYEILSSIF--TPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMV PEDHC_895_PE28 NOISO GEVLTNKPLIARLEILEKII--EPEEGTIIILNRKQISSNSEVIDSLNEAIDNREEGIVM PIG11_78_PE2 NOISO SKKLGHETLKNRYEILSSVF--TPIPGRIEIVPKTQAHTKKEVIDALNEAIDKREEGIMI POEGU1_36_PE9 NOISO DQKLGHEVLSKRYEILSSVF--TPVKGRIHVVHKRSARTRKEVIDALNEAIDNREEGIMV PONPY13RD_5_PE1 NOISO NKKLGHETLRKRYEILSSIF--TPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMI PTEVAGS_3160_PE1 NOISO NKKLGHETLRKRYEILTSII--TPIPGRIEIVQKTQAHTKKEVIDALNEAIDKREEGIMV RABIT8_113_PE3 NOISO NKKLGRETLRNRYEILSSVF--TPVPGRIEIVQKTLAHTKNEVIDALNEAIDKREEGIMI RAT16_PE902 NOISO NKKLGRETLRKRYDILSSTF--TPIQGRIEIVQKTQAQTKQEVVDALNDAIDKREEGIMV SORAR229595_PE1 NOISO SKKLGHETLRKRYEILGSVL--TPVAGRIEIVQKTQAHSKKEVIDALNEAIDKREEGIMV SPIPN_1_834 NOISO NQSLVDQTLKDRRAYLHRII--KEKETFLEILPHEEASTVEDVINHLGQRIDRSEEGIII STRPU_5557_PE5 NOISO DTKLANRPLKERLNYLPKVF--TVIEGRMVLVERRDASTKAEVVEALNEAIDKREEGIVV TARSY13215_PE1 NOISO NKKLGHETLKKRYEILSSTF--MPIPGRIEMVQKKLGHTKNEVIDALNEAIDKREEGIMV TETNG3_PE307 NOISO DRKLGKEPLKKRYEALQTVF--TPVKGRIHLVSKSDARSTQEVVKALNEAIDSREEGIMV THTRA1_1_9125 NOISO GVSTVNLPLSQRIEILERDVGLVADPKRIEIAPQTIGKSGDDIYDALEEAMANQEEGIMV TRIAD_735_PE506 NOISO GKKLANHSLHERLGYLKQVF--TPIPGRIMVVKQRQATSKKDVLDSLNEAIDTREEGIII TUPGBGS_4574_1_PE1 NOISO NKKLGHETLRKRYEILSSTF--APIPGRVEIVQKTQAHTKNEVIDALNEAIDKREEGIMI TURTRGS_2813_PE1 NOISO DKKLGQETLRKRYEILNSVF--TPIPGRIEIVQKTQAHTKKEVIDALNEAIDKREEGIMI XENTR42_2_PE40 NOISO DQKLAHETLRKRYDILQEIF--IPIPGRFHIVDKTEASTKKNVVDALNEAIDKREEGIMV MATCH * : . . :: * : : ***::: CONSENSUS ??KL??E?L??R???L???F???P??GR???V?K??A????EV??ALNEAID?REEGIM?

ACYPI_13021_PE4 NOISO KDPLSIYKPNSR-NAGWYKIKPEYTDGALIELDLLIIGGFYGEGK-KRGVVSHFLMGLLE AILMEGL192446_1_1_PE4 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVDGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE ANOCA3_12_PE8 NOISO KDPMSAYKPDKR-GEGWLKIKPEYVNGLMDELDLLVVGGYWGKGL-RGGMMSHFLCAVAE BOVIN12_84_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVNGLMDELDILIIGGYWGKGA-RGGMMSHFLCAVSE CALJA1_24_PE3 ENSCJAG00000014689 KRPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE CALJA1_24_PE4 ISOFORMIN KRPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE CANFA22_61_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVDGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE CAOWC1_1_4653 NOISO KNMKSTYAPDKR-DGGWYKIKPEYGDSF-AELDVLIVGGYYGIGKRRGGMVSHFMCAVAV CAVPO5_18_PE4 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVNGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE CHICK1_PE2311 NOISO KDPMSTYKPDKR-GEGWLKIKPEYVNGLMDELDLLIVGGYWGKGS-RGGMMSHFLCAIAE CIOSAREFTIG_1_3_PE120 NOISO KNPSAKYCPNKRKGSGWFKIKPEYVGGVVDDLDLAVIGATFGTGH-HGNMLSMFHLGVGV DANRE1_29_PE19 NOISO KDPMSIYKPDKR-GEGWLKIKPEYVDGLMDELDLLIVGGYWGKGR-RSGMLSHFLCAVAE ECHTE287220_PE1 NOISO KYPLSIYKPDKR-GEGWLKIKPEYVSDLMDQLDILIVGGYWGKGS-RGGMMSHFLCAVAE FUGRU64_1_PE62 NOISO KDPSSIYKPDKR-GEGWLKIKPEYVDGLMDELDLLIVGGYWGKGR-RGGMMSHFLCAVAE GASACGROUPI_22_PE33 NOISO KDPMSLYKPDKR-GEGWLKIKPEYVDGLMDELDLLIVGAYWGKGR-RGGMMSHFLCAVAE GORGO13_95_PE1 NOISO KQPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE HORSE17_78_PE2 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVNGLTDELDILIVGGYWGKGS-RGGMMSHFLCAVAE HS13_PE971 ENSG00000174405 KQPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE HS13_PE972 ISOFORMIN KQPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE HS13_PE973 ISOFORMIN KQPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE LOXAF29_29_PE2 NOISO KYPLSIYKPGKR-GEGWLKIKPEYVNGLMDELDILIVGGYWGKGL-RGGMMSHFLCAVAE MACMU17_91_PE2 ENSMMUG00000008874 KQPLSIYKPDKR-GEGWLKIKPEYVTGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE MACMU17_91_PE3 ISOFORMIN KQPLSIYKPDKR-GEGWLKIKPEYVTGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE MACMU17_91_PE4 ISOFORMIN KQPLSIYKPDKR-GEGWLKIKPEYVTGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE MICMUGS_3684_1_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVSELMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE MONDO7_88_PE3 NOISO KNPLSIYKPDKR-GEGWLKIKPEYINELMDELDILIVGGYWGKGL-RGGMMSHFLCAVAE MOUSE8_PE100 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDVLIVGGYWGKGS-RGGMMSHFLCAVAE NEMVE_3080_PE8 NOISO KSRDSVYKPNVRNGGGWLKIKPEYVASLSDDLDVVIVGGYFGVGR-RQGMVSHFLCAVAV OCHPRGS_4191_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGL-RGGMMSHFLCAVAE ORYLA2_24_PE32 NOISO KDPLSIYKPDKR-GEGWLKIKPEYVDSLMDELDLLIVGGYWGKGR-RGGMMSHFLCAVAE PANTR13_111_PE1 NOISO KQPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE PEDHC_895_PE28 NOISO KESMSVYKPNVRKNGGWYKIKPEYTDGLAETLDLLIIGGYYGRGH-LKGSVNHFLLGAAV PIG11_78_PE2 NOISO KYPLSIYKPDKR-GEGWLKIKPEYVNGLMDELDILIVGGYWGKGA-RGGMMSHFLCAVAE POEGU1_36_PE9 NOISO KDPMSTYKPDKR-GEGWLKIKPEYVNGLMDELDLLIVGGYWGKGS-RGGMMSHFLCAVAE PONPY13RD_5_PE1 NOISO KQPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE PTEVAGS_3160_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDVIIVGGYWGKGS-RGGMMSHFLCAVTE RABIT8_113_PE3 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGL-RGGMMSHFLCAVAE RAT16_PE902 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVTGLMDELDLLIVGGYWGKGS-RGGMMSHFLCAVAE SORAR229595_PE1 NOISO KNPFSIYKPDKR-GEGWLKIKPEYVTGLMDELDILLVGGYWGKGS-RGGMMSHFLCAVAE SPIPN_1_834 NOISO KNPASVYTPNLR-GDAWLKLKADYVDTLGDDVDLLIVGGLFGEGR-RGGRLSHFMCAIAE STRPU_5557_PE5 NOISO KHPESTYRPDKRK-VVGLKIKPEYVDNLMDELDLLIVGGYFGKGY-RSQLISHFLCALAV TARSY13215_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVNGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE TETNG3_PE307 NOISO KDPLSIYKPDKR-GEGWLKIKPEYVDGLMDELDLLIVGGYWG-GR-RGGMMSHFLCAVAE THTRA1_1_9125 NOISO KSLNSVWKAGDR-SHGWLKIKPEYGDRTADDLDVLIVGGYYGTGH-RSGLIAKFMLGVIV TRIAD_735_PE506 NOISO KNPISTYKPDQRKGSGWFKIKPEYVDSLSDQLDLLIIGGYFGVGR-RGGLISHFLLGVAV TUPGBGS_4574_1_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVSGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVAE TURTRGS_2813_PE1 NOISO KHPLSIYKPDKR-GEGWLKIKPEYVNGLMDELDILIVGGYWGKGS-RGGMMSHFLCAVSE XENTR42_2_PE40 NOISO KDPMSIYKPDKR-GEGWLKIKPEYVNGLMDELDLIIIGGYWGKGS-RGGMMSHFLCGVAE MATCH * : : .. * *:*.:* :*: ::*. :* * : * . CONSENSUS K?P?S?YKPDKR?GEGWLKIKPEYV??LMDELD?LIVGGYWGKG??RGGM?SHFLCAVAE

ACYPI_13021_PE4 NOISO KD----GE-SFKCSAISRVSSGFSTEELADLSRKLSSHWQRVYPGKMPPNIEW---GKEK AILMEGL192446_1_1_PE4 NOISO KP--PPGEKPSVFHTLCRVGSGYTMKELYDLGLKLAKHWKPFHKKAPPSSILC---GTEK ANOCA3_12_PE8 NOISO TP--PPGEKPSVFHSICRVGSGYTMKELYDLGLKLAKYWKPYRKRDPPCSILC---GTEK BOVIN12_84_PE1 NOISO KP--PSGEKPSVFHTLCRVGSGYTMKELYDLGLKLAKHWKPFHRKAPPSNILC---GTEK CALJA1_24_PE3 ENSCJAG00000014689 KP--PPGKKPSVFHTLSRVGSGCTMKELYDLGLRLAKYWRPFHKKTPPSSILC---GTEK CALJA1_24_PE4 ISOFORMIN KP--PPGKKPSVFHTLSRVGSGCTMKELYDLGLRLAKYWRPFHKKTPPSSILC---GTEK CANFA22_61_PE1 NOISO KP--PPGEKPSVFHTLCRVGSGYTMKELYDLGLKLAKHWKPFHKKALPSSILC---GTEK CAOWC1_1_4653 NOISO PP-ANPQEPPTVFHSFCKVGTGYSMSQLKEFGEQLEPHWHPFDTQNPPSQILLATGFKER CAVPO5_18_PE4 NOISO KP--PSGEKPTVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFHKKAPPSSILC---GTEK CHICK1_PE2311 NOISO TP--APNEKPTVFHSICRVGSGYTMKELYDLGLKLAKHWKPYNRKDPPCNILC---GTEK CIOSAREFTIG_1_3_PE120 NOISO RDSDDTSRPPEVFKSFCRIGSGYTDKQLLQIVAKIKDKLKVFDKKKVPDWLRV---TKEK DANRE1_29_PE19 NOISO VP--SPGEKPTVFHTLCRIGSGYTLKELYDLGVKLAKHWKVYNKNNPPAAILC---GTEK ECHTE287220_PE1 NOISO KP--PPGKKPSAFHTLCRVGSGYTMKELYDLGLKLAKHWKPFNKKAPPCSILC---GTEK FUGRU64_1_PE62 NOISO AP--KPGEKPSVFHTLCRIGSGYTMKELYELGLKLAKHWKVFRKSDPPASILC---AAEK GASACGROUPI_22_PE33 NOISO AP--KLGEKPSVFHTLCRIGSGYTMKELYDLGLKLAKHWRVYRKNDPPASILC---GTEK GORGO13_95_PE1 NOISO KP--PPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC---GTEK HORSE17_78_PE2 NOISO KP--PAGEKPSVFHTLCRVGSGYTMKELYDLGLKLAQHWKPFHKKAPPSSILC---GIEK HS13_PE971 ENSG00000174405 KP--PPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC---GTEK HS13_PE972 ISOFORMIN KP--PPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC---GTEK HS13_PE973 ISOFORMIN KP--PPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC---GTEK LOXAF29_29_PE2 NOISO KP--PTGEKPSVFHTVCRVGSGYTMKELYDLGLKLANHWKPFNRKAPPSSILC---GTEK MACMU17_91_PE2 ENSMMUG00000008874 KP--PPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHKKAPPSSILC---GTEK MACMU17_91_PE3 ISOFORMIN KP--PPGEKPSVFHTLSRVGSGCTMKELYDL-------------EAPPSSILC---GTEK MACMU17_91_PE4 ISOFORMIN KP--PPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHKKAPPSSILC---GTEK MICMUGS_3684_1_PE1 NOISO KP--PPGEKPSVFHTLSRVGSGYTMKELYDLGLKLARHWKPFHKKTPPCSILC---GTER MONDO7_88_PE3 NOISO TP--PPGEKPSVFYTLCRVGSGYTMKELYDLGLKLSKHWKPFHKRAPPNSILC---GTEK MOUSE8_PE100 NOISO TP--PPGDRPSVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFHKKSPPSSILC---GTEK NEMVE_3080_PE8 NOISO PS-DRRGEKPSQFYSLCKVGSGYTMNELDELGQQLKPHWQPFNQAKPPKSVCFTPGFKEK OCHPRGS_4191_PE1 NOISO KP--PPGEKPSVFHTLCRVGSGYTMKELYDLGLKLNKCWKPFHRKAPPGSILC---GTEK ORYLA2_24_PE32 NOISO AP--KPGEKPSVFHSLCRIGSGYTMKELYDLGLKLAKHWKVYRRSDPPPSLLC---STEK PANTR13_111_PE1 NOISO KP--PPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC---GTEK PEDHC_895_PE28 NOISO NV----SDDNILFYSTGRVGSGYSIKDLEDLSLKLKPYWKEAKNDRMPLSVKW---GKEK PIG11_78_PE2 NOISO KP--PAGEKPSVFHTLCRVGSGYTMKELYDLGLKLAKHWKPFHRKAPPGSILC---GTEK POEGU1_36_PE9 NOISO TP--PPNEKPTIFHSICRVGSGYTMKELYDLGLKLAKHWKPYHRKDPPGNILC---GAEK PONPY13RD_5_PE1 NOISO KP--PLGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHKKAPPSSILC---GTEK PTEVAGS_3160_PE1 NOISO KP--PSGEKPSVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFHKKAPPRSIVC---GTEK RABIT8_113_PE3 NOISO RP--PPGEKPSVFHTLCRVGSGYTMKELYDLGLKLAKHWKPFHRKAPPGSILC---GTEK RAT16_PE902 NOISO TP--PPGDKPSVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFQRKSPPSCILC---GTEK SORAR229595_PE1 NOISO KP--PPGEKPSVFHSLCRVGSGYTMRELYDLGVKLAKHWKPFHKRAPPSSILC---GTEK SPIPN_1_834 NOISO DA--KPGETP-RFISFCKVGSGFKIKEMDELSRYREGFWRPYDPRRPPPWFVHPSNSKEK STRPU_5557_PE5 NOISO PP-SREGDHPKIFYSFCKVGSGYTLQELLDFNQKLAKHWKKYDKENPPRWLQC---TREK TARSY13215_PE1 NOISO KP--PPGEKPSVFHTLTRVGSGYTMKELYDLGLKLAKHWKAFHKRAPPSSILC---GTEK TETNG3_PE307 NOISO AP--KPGEKPSVFHTLCRIGSGYTMKELYDLGLKLAKHWKVFRKSDPPASILC---GTEK THTRA1_1_9125 NOISO PP-AVPGGKPSVFYSFTKVGTGYSVDTLRNLDAALGDRWIPYSTDSPPPHLILADGFKEK TRIAD_735_PE506 NOISO PP-ENPSEHPKVFQSFCKVGSGYTIAELKELGEKLKPYWKPMNPKKLPPYFQL---MSEK TUPGBGS_4574_1_PE1 NOISO NP--PPGEKPSVFHTLCRVGSGYTMKELYDLGLKLAKHWKPFHKKSPPSSILC---GTEK TURTRGS_2813_PE1 NOISO KP--PPGEKPSVFHTLCRVGSGYTMKELYDLGLKLAQHWKPFHKKAPPSCILC---GTEK XENTR42_2_PE40 NOISO AS--GPGEKPSVFHSICRVGSGYTMKELFDLGLKLAPHWKTYRKRDPPSNILC---GIEK MATCH : ::.:* . : :: * . *: CONSENSUS ?P????GEKP?VFH???RVGSG?TMKEL?DLG?KL???WK??????PP??ILC???G?EK

ACYPI_13021_PE4 NOISO PDLWIEPESSVIVQVKATEIMTS-NIFKSKITLRFPRIERVRYDKPWHDCLTVEEFESII AILMEGL192446_1_1_PE4 NOISO PEVYIEPCHSVIVQVKATEIVSS-DMYKAGCTLRFPRIERIREDKEWHECTTVDDLEQLR ANOCA3_12_PE8 NOISO PEVYIEPCNSVIVQIKAAEIVNS-DMYKTECTLRFPRIEKIREDKEWHECMTLDLLEQLR BOVIN12_84_PE1 NOISO PEVYIEPCNSVIVQVKATEIVPS-DMYKTGCTLRFPRIEKIREDKEWYECTSLEDLEQLR CALJA1_24_PE3 ENSCJAG00000014689 PEVYIEPCNSVIVQIKAAEIVPS-DIYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLR CALJA1_24_PE4 ISOFORMIN PEVYIEPCNSVIVQIKAAEIVPS-DIYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLR CANFA22_61_PE1 NOISO PEVYIEPCNSVIVQVKATEIVSS-DMYKTGCTLRFPRIEKIREDKEWHECTTVDDLEQLR CAOWC1_1_4653 NOISO PDVWIEPRHSRIVQIRAAEITPT-EKYKCGFTLRFPRLECFRTDKEWSDCMTTTELDHAY CAVPO5_18_PE4 NOISO PEVYIEPCHSVIVQIKAAEIVPS-EMYKTCCTLRFPRIEKIRDDKEWHECMTLDQLEQLG CHICK1_PE2311 NOISO PEMYIEPCNSVIVQIKAAEIVNS-DMYKTDCTLRFPRIEKIREDKEWYECMTLDMLEHLR CIOSAREFTIG_1_3_PE120 NOISO PDVYIHPRDSIVVQVRATEI