Alignment of the gene Family HOG000111530 of HOGENOM
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Isoforms are
ON
AILMEGL193124_1_PE32
NOISO
E
TPERA-QCH
F
S
KG
L
L
L
S
A
S
V
L
A
L
W
IP
Q
G
S
W
A
A
L
R
I
Q
K
I
P
E
H
P
Q
K
D
E
N
L
L
L
S
V
Q
G
I
P
G
A
F
BOVIN18_53_PE11
NOISO
E
IPAGS-QHA
F
P
KS
L
L
L
S
A
S
I
L
A
L
W
VP
Q
G
S
W
A
A
L
R
I
Q
K
I
P
E
Q
P
Q
M
N
Q
D
L
L
L
S
V
Q
G
I
P
N
T
F
CALJA22_36_PE71
ENSCJAG00000013193
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
S
S
Q
A
A
L
H
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
CALJA22_36_PE72
ISOFORMIN
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
S
S
Q
A
A
L
H
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
CANFA1_116_PE19
NOISO
E
IPEWA-QHY
F
S
KG
L
L
L
S
A
S
I
L
A
L
W
IP
Q
-
S
W
A
A
L
R
I
Q
K
I
P
E
Y
P
Q
K
D
Q
D
L
L
L
S
V
Q
G
I
P
G
N
F
CAVPO6_44_PE7
ENSCPOG00000022078
E
TPAGT-LGC
F
S
AG
L
L
L
S
A
S
V
L
A
L
W
LP
H
C
T
Q
I
A
L
C
I
Q
K
I
P
E
H
P
Q
K
N
Q
N
L
L
L
S
I
Q
G
V
P
S
T
F
CAVPO6_44_PE8
ISOFORMIN
E
TPAGT-LGC
F
S
AG
L
L
L
S
A
S
V
L
A
L
W
LP
H
C
T
Q
I
A
L
C
I
Q
K
I
P
E
H
P
Q
K
N
Q
N
L
L
L
S
I
Q
G
V
P
S
T
F
CAVPO80_6_PE9
NOISO
E
TPAGT-LGC
F
S
AG
L
L
L
S
V
L
I
L
S
M
E
LP
D
A
E
Q
T
S
L
V
N
P
R
T
A
L
S
T
Q
C
L
E
L
F
R
M
R
T
H
G
V
P
S
T
F
CHOHOGS_693_PE2
NOISO
E
TLTEA-LGP
F
S
KG
L
L
L
S
A
T
I
L
A
I
W
IP
Q
D
S
W
A
V
L
H
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
A
G
V
P
D
T
F
FELCAGS_388_PE2
NOISO
A
SPEGA-RRH
F
S
KG
L
L
L
S
A
S
I
L
A
L
W
VP
Q
G
S
R
A
A
L
R
I
Q
K
I
P
E
H
P
Q
K
N
Q
D
L
L
L
S
V
R
G
I
P
D
T
F
GORGO19_43_PE22
ISOFORMIN
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
Y
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
GORGO19_43_PE23
ENSGGOG00000009234
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
Y
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
GORGO19_43_PE24
ISOFORMIN
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
Y
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
HORSE10_16_PE14
NOISO
E
TPVGA-QCC
F
S
KG
L
L
L
S
A
S
I
L
V
L
W
AP
Q
G
S
W
A
A
L
H
I
Q
K
I
P
E
H
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
E
T
F
HS19_PE2315
ISOFORMIN
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
Y
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
HS19_PE2316
ENSG00000186567
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
Y
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
LOXAF4_4_PE9
NOISO
K
ISTRA-QGC
Y
S
KD
F
L
L
P
A
S
I
L
A
L
W
TL
Q
S
S
Q
A
A
L
H
I
Q
K
I
P
E
Q
P
L
K
D
Q
D
L
L
L
S
V
Q
G
I
P
G
T
F
MACMU19_52_PE39
NOISO
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
H
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
MONDO4_376_PE10
ISOFORMIN
-
---------
-
-
--
-
-
L
T
A
S
L
L
A
W
W
TV
Q
Q
A
W
A
G
L
L
I
E
K
I
P
E
T
P
Q
E
G
Q
D
V
L
L
T
V
H
G
V
P
A
A
I
MONDO4_376_PE9
ENSMODG00000020864
-
-DFGL-HNF
F
S
--
A
P
L
T
A
S
L
L
A
W
W
TV
Q
Q
A
W
A
G
L
L
I
E
K
I
P
E
T
P
Q
E
G
Q
D
V
L
L
T
V
H
G
V
P
A
A
I
MOUSE7_PE603
NOISO
-
METWTPPGC
F
S
KG
L
L
F
S
A
L
F
L
A
L
E
LP
Q
G
S
Q
A
A
L
H
I
E
M
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
L
H
G
V
P
S
T
A
PANTR19_52_PE5
NOISO
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
Y
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
PIG6_37_PE10
NOISO
E
IPAGA-QQP
F
P
RG
L
L
L
S
A
S
I
L
A
L
W
VP
Q
G
S
W
A
A
L
R
I
Q
K
I
P
E
Q
P
Q
T
N
Q
D
L
L
L
S
V
Q
G
I
P
G
S
F
PONPY19_47_PE16
NOISO
E
IPMGT-QGC
F
S
KS
L
L
L
S
A
S
I
L
V
L
W
ML
Q
G
S
Q
A
A
L
Y
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
V
P
D
T
F
PTEVAGS_3586_PE1
NOISO
E
IPMGS-QCH
F
S
KG
L
L
L
S
A
L
L
L
A
L
W
VP
R
G
S
W
A
A
L
R
I
Q
K
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
V
Q
G
I
P
G
T
F
RAT1_PE1018
NOISO
E
IQTWM-PGC
F
S
KG
L
L
F
S
A
L
F
L
A
L
R
LP
Q
G
S
Q
A
A
L
H
I
Q
M
I
P
E
Q
P
Q
K
N
Q
D
L
L
L
S
L
H
G
V
P
S
T
V
MATCH
:.. .* * . . : . : *:*
CONSENSUS
E?????????FS??LLLSAS?L?LW??Q?S?AAL?IQKIPE?PQK?QDLLLSV?G?P?TF
AILMEGL193124_1_PE32
NOISO
Q
D
F
N
W
Y
L
G
E
E
TN
G
G
A
M
L
F
T
Y
F
P
DLQ
R
P
Q
R
D
G
S
D
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
H
R
V
Q
P
T
D
S
G
T
Y
BOVIN18_53_PE11
NOISO
Q
D
F
S
W
Y
L
G
E
E
AN
G
G
T
M
L
F
T
Y
I
P
KLL
R
P
Q
R
D
G
S
A
M
H
Q
R
D
I
V
G
F
S
N
G
S
M
L
L
R
H
A
Q
P
S
D
S
G
T
Y
CALJA22_36_PE71
ENSCJAG00000013193
Q
D
I
N
W
Y
L
G
E
E
IY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
CALJA22_36_PE72
ISOFORMIN
Q
D
I
N
W
Y
L
G
E
E
IY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
CANFA1_116_PE19
NOISO
Q
D
F
N
W
Y
L
G
E
E
TN
G
G
T
M
L
F
T
Y
F
P
DLQ
W
P
Q
R
D
G
S
A
M
G
Q
H
D
I
V
G
F
P
N
G
S
M
M
L
H
R
V
Q
P
T
D
S
G
T
Y
CAVPO6_44_PE7
ENSCPOG00000022078
Q
D
F
M
W
Y
L
G
G
-
--
-
G
M
R
L
F
T
Y
I
P
ELQ
R
P
P
W
D
G
S
A
M
G
Q
Q
D
I
V
G
F
P
N
G
S
M
L
L
R
Q
A
Q
P
S
D
S
S
T
Y
CAVPO6_44_PE8
ISOFORMIN
Q
D
F
M
W
Y
L
G
E
-
--
-
E
A
R
L
F
T
Y
I
P
ELQ
R
P
P
W
D
G
S
A
M
G
Q
Q
D
I
V
G
F
P
N
G
S
M
L
L
R
Q
A
Q
P
S
D
S
S
T
Y
CAVPO80_6_PE9
NOISO
Q
N
F
M
W
Y
L
G
E
E
AD
G
G
T
R
L
F
T
Y
I
P
GLQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
S
D
S
G
T
Y
CHOHOGS_693_PE2
NOISO
Q
D
L
N
W
Y
L
G
E
E
IS
G
S
T
R
L
F
S
Y
I
P
GLQ
R
P
Q
R
D
G
N
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
X
FELCAGS_388_PE2
NOISO
Q
D
F
N
W
Y
L
G
E
E
AH
G
G
T
M
L
F
T
Y
I
P
ELQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
H
R
A
Q
P
T
D
S
G
T
Y
GORGO19_43_PE22
ISOFORMIN
Q
D
F
N
W
Y
L
G
E
E
TY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
GORGO19_43_PE23
ENSGGOG00000009234
Q
D
F
N
W
Y
L
G
E
E
TY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
GORGO19_43_PE24
ISOFORMIN
Q
D
F
N
W
Y
L
G
E
E
TY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
HORSE10_16_PE14
NOISO
Q
D
F
N
W
Y
L
G
E
D
AY
G
G
T
R
L
F
T
Y
I
P
GLQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
T
Q
P
G
D
S
G
T
Y
HS19_PE2315
ISOFORMIN
Q
D
F
N
W
Y
L
G
E
E
TY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
HS19_PE2316
ENSG00000186567
Q
D
F
N
W
Y
L
G
E
E
TY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
LOXAF4_4_PE9
NOISO
Q
D
F
N
W
Y
Q
G
E
E
TS
G
S
T
M
L
F
S
Y
I
P
GLQ
R
P
Q
R
D
G
S
A
M
R
Q
R
D
I
V
G
F
A
N
G
S
M
L
L
R
R
A
Q
P
S
D
S
G
I
Y
MACMU19_52_PE39
NOISO
Q
D
F
N
W
Y
L
G
E
E
MY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
MONDO4_376_PE10
ISOFORMIN
K
D
F
N
W
Y
Q
G
E
E
VD
G
S
T
M
I
F
S
Y
F
P
GLP
R
P
Q
R
N
G
N
A
L
Q
G
R
N
I
I
G
F
P
N
G
S
F
L
L
R
H
V
Q
L
T
D
S
G
I
Y
MONDO4_376_PE9
ENSMODG00000020864
K
D
F
N
W
Y
Q
G
E
E
VD
G
S
T
M
I
F
S
Y
F
P
GLP
R
P
Q
R
N
G
N
A
L
Q
G
R
N
I
I
G
F
P
N
G
S
F
L
L
R
H
V
Q
L
T
D
S
G
I
Y
MOUSE7_PE603
NOISO
Q
D
F
I
W
Y
L
G
E
E
AS
G
G
T
R
L
F
S
Y
I
P
GLP
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
N
A
Q
P
S
D
S
G
T
Y
PANTR19_52_PE5
NOISO
Q
D
F
N
W
Y
L
G
E
E
TY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
T
D
S
G
T
Y
PIG6_37_PE10
NOISO
Q
D
L
T
W
Y
L
G
E
-
AD
G
G
T
M
L
F
T
Y
I
P
ELL
R
P
Q
R
D
S
S
S
M
K
Q
R
D
I
D
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
A
D
S
G
T
Y
PONPY19_47_PE16
NOISO
Q
D
F
N
W
Y
L
G
E
E
TY
G
G
T
R
L
F
T
Y
I
P
GIQ
R
P
Q
R
D
G
S
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
R
A
Q
P
A
D
S
G
T
Y
PTEVAGS_3586_PE1
NOISO
Q
D
F
I
W
Y
L
G
E
E
AY
G
G
T
R
L
F
T
Y
I
P
ELE
R
P
Q
R
D
G
S
A
M
K
Q
R
D
I
V
G
F
R
N
G
S
M
L
L
H
H
A
Q
P
S
D
S
G
T
Y
RAT1_PE1018
NOISO
Q
D
F
I
W
Y
L
G
E
E
TS
G
G
T
R
L
F
S
Y
I
P
GLP
R
P
Q
R
D
G
N
A
M
G
Q
R
D
I
V
G
F
P
N
G
S
M
L
L
R
G
A
Q
P
S
D
S
G
T
Y
MATCH
::: ** * :*:*:* : * :.. : ::* ** ***::*: .* **.
CONSENSUS
QDF?WYLGEE??GGT?LF?YIP???RPQRDGSAM?QRDIVGFPNGSMLLR?AQP?DSGTY
AILMEGL193124_1_PE32
NOISO
Q
V
A
V
T
I
N
PD
W
T
M
R
A
K
T
E
V
R
V
A--EKLK--ELPITQLPVSA
G
IMA
T
I
L
I
G
S
L
AA
G
S
L
FIG-
BOVIN18_53_PE11
NOISO
Q
V
A
V
T
I
N
PS
W
T
M
R
A
K
T
E
V
Q
V
V--EKPK--ELPVTNPPVSA
G
IVA
A
I
V
I
G
S
L
AT
G
C
M
SVG-
CALJA22_36_PE71
ENSCJAG00000013193
Q
V
A
I
T
I
N
SD
W
T
M
K
T
K
T
E
V
Q
V
A--ERNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
TA
G
A
L
LIS-
CALJA22_36_PE72
ISOFORMIN
Q
V
A
I
T
I
N
SD
W
T
M
K
T
K
T
E
V
Q
V
A--ERNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
TA
G
A
L
LIS-
CANFA1_116_PE19
NOISO
Q
V
A
V
N
I
N
PA
W
I
M
R
A
K
T
E
V
Q
V
A--EKHK--ELPIIHLPVSA
G
IMA
A
I
I
I
G
S
L
SA
G
S
L
FIC-
CAVPO6_44_PE7
ENSCPOG00000022078
Q
A
A
C
W
P
S
NT
W
T
G
K
Q
E
R
T
S
L
L
P-AERQEDLPTATTHLSVSP
G
VMV
A
A
I
V
G
P
L
A-
G
A
L
LVS-
CAVPO6_44_PE8
ISOFORMIN
Q
A
A
C
C
H
R
PP
P
A
R
-
-
-
-
-
-
-
-
A-RGPQAGASTATTHLSVSP
G
VMV
A
A
I
V
G
P
L
A-
G
A
L
LVS-
CAVPO80_6_PE9
NOISO
Q
V
A
I
A
V
N
PA
W
T
L
R
A
K
T
K
V
R
V
AKRQEDL--PTATTHLSMSP
G
VMV
A
A
I
V
G
P
L
AA
G
A
L
LVS-
CHOHOGS_693_PE2
NOISO
X
X
X
X
X
X
X
XX
X
X
X
X
X
X
X
X
-
-
X
XXXXQPK--ELPVAHWPTNA
G
IMA
A
I
I
I
G
S
L
AM
G
T
L
LVG-
FELCAGS_388_PE2
NOISO
Q
V
A
V
T
I
N
PA
W
T
M
R
A
K
T
K
V
Q
V
E--EKHK--EPPITHLPMSV
G
IMV
A
I
I
I
G
S
L
AA
G
A
L
FIG-
GORGO19_43_PE22
ISOFORMIN
Q
V
A
I
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--EKNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
AA
G
A
L
LIS-
GORGO19_43_PE23
ENSGGOG00000009234
Q
V
A
I
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--EKNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
AA
G
A
L
LIS-
GORGO19_43_PE24
ISOFORMIN
Q
V
A
I
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--EKNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
AA
G
A
L
LIS-
HORSE10_16_PE14
NOISO
Q
V
A
V
T
V
N
PA
W
T
M
R
A
K
T
E
V
Q
V
A--EKHQ--ELPITQLPMSA
G
IMA
A
I
I
I
G
S
L
AA
G
S
L
FIG-
HS19_PE2315
ISOFORMIN
Q
V
A
I
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--EKNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
AA
G
A
L
LIS-
HS19_PE2316
ENSG00000186567
Q
V
A
I
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--EKNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
AA
G
A
L
LIS-
LOXAF4_4_PE9
NOISO
Q
V
A
V
T
I
N
PS
W
T
M
K
A
K
T
E
V
R
V
SGAEQQQ--KLLSAHSSVNI
G
IVA
A
I
I
I
G
S
L
VA
G
G
L
VIG-
MACMU19_52_PE39
NOISO
Q
V
A
V
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--G----------------
-
---
-
-
-
-
-
-
-
--
-
-
-
----
MONDO4_376_PE10
ISOFORMIN
Q
V
G
I
T
F
N
PS
W
I
M
R
A
K
T
E
L
K
V
I--------GEWHSSSAVNS
G
TLV
A
I
V
L
G
C
V
GL
G
A
L
IVGG
MONDO4_376_PE9
ENSMODG00000020864
Q
V
G
I
T
F
N
PS
W
I
M
R
A
K
T
E
L
K
A
SPVHKHQ--SGKHSSSAVNS
G
TLV
A
I
V
L
G
C
V
GL
G
A
L
IVGG
MOUSE7_PE603
NOISO
Q
V
A
A
T
M
N
PA
W
T
M
K
A
K
I
N
V
H
V
AG------AREVSSLLPVHA
G
ITV
A
I
I
I
G
S
L
AI
G
S
L
LVC-
PANTR19_52_PE5
NOISO
Q
V
A
I
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--EKNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
AA
G
A
L
LIS-
PIG6_37_PE10
NOISO
Q
V
A
V
T
I
N
PA
W
T
M
R
A
K
T
E
V
Q
V
A--EKPK--ELSITNLPMSA
G
IVA
A
I
I
I
G
S
L
AT
G
S
V
FVG-
PONPY19_47_PE16
NOISO
Q
V
A
I
T
I
N
SE
W
T
M
K
A
K
T
E
V
Q
V
A--EKNK--ELPSTHLPTNA
G
ILA
A
T
I
I
G
S
L
AA
G
A
L
LIS-
PTEVAGS_3586_PE1
NOISO
H
V
E
V
T
I
N
PS
W
T
M
R
A
K
T
E
V
H
V
S--EKQT--ELPITQLPVTT
G
IAA
A
I
I
I
G
S
L
AA
G
S
L
FIG-
RAT1_PE1018
NOISO
Q
V
A
A
T
V
N
PA
W
T
M
K
A
K
I
D
V
Q
V
AEKNDNLYARKVSSLLSANA
G
ITT
A
I
I
V
G
S
L
AV
G
S
L
LLC-
MATCH
CONSENSUS
QVA?T?N??WTM?AKT?V?V????????????????????G???A?I?G?L??G?L????
AILMEGL193124_1_PE32
NOISO
F
I
A
H
L
L
L
T
R
GW
R
G---QSHGYRGPRPLSPSLCLLPHPLGPPLTAA--SVGLWA---ACQP
BOVIN18_53_PE11
NOISO
I
I
A
Y
L
L
V
T
R
GW
R
A---QNHRI---------------------------------TATEKP
CALJA22_36_PE71
ENSCJAG00000013193
C
I
A
Y
L
L
V
T
R
NW
R
G---QSHRVSAPGGQGSLSVLCPAVS--PVPSV--TPSTWLDGTTEKP
CALJA22_36_PE72
ISOFORMIN
C
I
A
Y
L
L
V
T
R
NW
R
G---QSHRYRVPSFSGSLSTHLSVSSLILFPSM-----CPQDGTTEKP
CANFA1_116_PE19
NOISO
C
I
A
H
L
L
L
T
G
GW
R
G---QSHRYRGPASL--SLCLLPHLLHPTV-----PTSVWRMTPTEKP
CAVPO6_44_PE7
ENSCPOG00000022078
S
I
T
C
L
L
V
L
R
DH
R
G---PSYPLPSPRGTHPLPQQTSAVLQDPTRHSSTLPKLPL--LPSIT
CAVPO6_44_PE8
ISOFORMIN
S
I
T
C
L
L
V
L
R
DH
R
G---PS----------------------------------------SS
CAVPO80_6_PE9
NOISO
S
I
T
C
L
L
V
L
R
DR
R
G---PSSRA---------------------------------TTTGKP
CHOHOGS_693_PE2
NOISO
S
I
T
Y
L
L
V
T
R
GW
R
G---QSH-----------------------------------------
FELCAGS_388_PE2
NOISO
S
I
A
H
L
L
L
T
R
SW
R
G---QSHXXXXXXXXXXXXXXXXXX---XXXXX--XXXXXXTTTTEEP
GORGO19_43_PE22
ISOFORMIN
C
I
A
Y
L
L
V
T
K
NW
R
G---QSHRLPAPGGQGSLSILCSAVS--PVPSV--TPSTWMA-TTEKP
GORGO19_43_PE23
ENSGGOG00000009234
C
I
A
Y
L
L
V
T
K
NW
R
G---QSHRYRVPKCPSPVSSHCRPVS--PVPWI--LFSTLMA-TTEKP
GORGO19_43_PE24
ISOFORMIN
C
I
A
Y
L
L
V
T
K
NW
R
G---QSHRYRVPKCPSPVSSHCLLK-----PLP--LCVPRMA-TTEKP
HORSE10_16_PE14
NOISO
I
I
A
Y
I
L
V
T
R
GW
R
S---QSHRASAPGAQGSLSALFPAVP--PVPST--MPTAAM-TTTEKR
HS19_PE2315
ISOFORMIN
C
I
A
Y
L
L
V
T
R
NW
R
G---QSHRLPAPRGQGSLSILCSAVS--PVPSV--TPSTWMA-TTEKP
HS19_PE2316
ENSG00000186567
C
I
A
Y
L
L
V
T
R
NW
R
G---QSHRLPAPRGQGSLSILCSAVS--PVPSV--TPSTWMA-TTEKP
LOXAF4_4_PE9
NOISO
S
L
A
Y
F
L
V
T
R
GC
K
G---QNHRM---------------------------------THTEKP
MACMU19_52_PE39
NOISO
-
-
-
-
-
-
-
-
-
--
-
------------------------------------------------
MONDO4_376_PE10
ISOFORMIN
G
L
A
Y
L
M
V
S
R
GW
R
IRSPGPPTSPPT------------------------------------
MONDO4_376_PE9
ENSMODG00000020864
G
L
A
Y
L
M
V
S
R
GW
R
IRSPGTLIHPPHRV----AGRQVAHPCPRLPW-----------ATEKS
MOUSE7_PE603
NOISO
G
I
A
Y
V
L
V
T
R
SR
K
GR------------------------------------SPRNPATEKP
PANTR19_52_PE5
NOISO
C
I
A
Y
L
L
V
T
R
NW
R
G---QSHR--------------------------------MA-TTEKP
PIG6_37_PE10
NOISO
S
I
A
Y
L
L
V
T
R
GW
R
A---QSHRYRSPRPFSPSLGLLCSRVQPYE--V--FFSFTMMMASEKP
PONPY19_47_PE16
NOISO
C
I
A
Y
L
L
V
T
R
NW
R
G---QSHRYRVPKCPSPVSSHCLLK---PLPPC----VPRMA-TTEKP
PTEVAGS_3586_PE1
NOISO
S
I
A
Y
L
L
V
T
R
GW
R
R---RSHXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXX
RAT1_PE1018
NOISO
G
I
A
Y
L
L
V
T
R
RH
R
HRKGQSPRYSSQNSLWVFHPLSFSSNSPAF--P--GLGTPRNTATEKP
MATCH
CONSENSUS
?IA?LLV?R??R????????????????????????????????????????????????
AILMEGL193124_1_PE32
NOISO
APP------LSSASGDQN
I
Y
E
V
M
P
S
P
TF
P
V
S
P
PGDTGSMSTSMP----L--------PQQ
BOVIN18_53_PE11
NOISO
ELG------PSHRAGDDS
I
Y
E
A
I
P
S
P
VL
L
V
S
P
CDT-GPMNTATPPDLPLPPPPPPPPPPP
CALJA22_36_PE71
ENSCJAG00000013193
ELG------PGHDAGKAG
A
Q
I
S
R
P
S
P
SL
G
P
V
P
ICAHPTHVL--------TLQPLPAPPPL
CALJA22_36_PE72
ISOFORMIN
ELG------PGHDAGKAG
A
Q
I
S
R
P
S
P
SV
S
S
S
-
LLPHSPHVL--------TLQPLPAPPPL
CANFA1_116_PE19
NOISO
EAR------PNLNAGDQH
I
Y
E
V
M
P
S
P
TH
L
V
S
P
LGGTASMNNTMP------------LPQQ
CAVPO6_44_PE7
ENSCPOG00000022078
WPS------PLSSASGDN
I
Y
E
V
T
P
S
P
HP
L
G
S
P
ASDVGLV---------NSATPPTVPPPL
CAVPO6_44_PE8
ISOFORMIN
WPS------PLSSASGDN
I
Y
E
V
T
P
S
P
HP
L
G
S
P
ASDQSRGGGCL-AQHPLSLQPPTVPPPL
CAVPO80_6_PE9
NOISO
ELS------PHPDPG-DN
I
Y
E
V
M
P
S
R
HP
L
G
S
P
ASDAGPVNSATPAKQR--------RWVP
CHOHOGS_693_PE2
NOISO
------------------
-
-
-
-
-
-
-
-
--
-
-
-
-
----------------------------
FELCAGS_388_PE2
NOISO
EAH------PKHNAGDEN
I
Y
E
V
M
P
S
P
TL
L
V
S
P
LGDPGSANT--------A--------MP
GORGO19_43_PE22
ISOFORMIN
ELG------PAHDAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
ISD-TRSIN--------PARPLPTPPHL
GORGO19_43_PE23
ENSGGOG00000009234
ELG------PAHDAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
ISD-TRSIN--------PARPLPTPPHL
GORGO19_43_PE24
ISOFORMIN
ELG------PAHDAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
ISD-TRSIN--------PARPLPTPPHL
HORSE10_16_PE14
NOISO
ELG------PSRNPGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
LSDTGLMNM---------ATPPAVPLPP
HS19_PE2315
ISOFORMIN
ELG------PAHDAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
ISD-TRSIN--------PARPLPTPPHL
HS19_PE2316
ENSG00000186567
ELG------PAHDAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
ISD-TRSIN--------PARPLPTPPHL
LOXAF4_4_PE9
NOISO
EYL------PLSPTSGDN
I
Y
E
V
M
P
S
P
GL
L
V
S
P
LSDTGLMHST------LKPPPLPPPMQP
MACMU19_52_PE39
NOISO
------------------
-
-
-
-
-
-
-
-
--
-
-
-
-
----------------------------
MONDO4_376_PE10
ISOFORMIN
-------------PDGSN
I
Y
E
V
I
H
S
P
GI
L
I
A
P
TSVTGIINPNLTPDSP---------QTR
MONDO4_376_PE9
ENSMODG00000020864
WVGLLSSLGPRFLTDGSN
I
Y
E
V
I
H
S
P
GI
L
I
A
P
TSVTGIINPNLTPDSP---------QTR
MOUSE7_PE603
NOISO
EVN------LSPESGDSN
I
Y
E
V
M
P
S
P
VF
L
V
S
P
ISDMEQGSP------PMSQPPPPPPASQ
PANTR19_52_PE5
NOISO
ELG------PAHDAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
ISD-TRSIN--------PARPLPTPPHL
PIG6_37_PE10
NOISO
ELG------PHHHAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
LSDTGSMNAM-------APPPLPPPPPP
PONPY19_47_PE16
NOISO
ELG------PPHDAGDNN
I
Y
E
V
M
P
S
P
VL
L
V
S
P
ISD-TRPLN--------PAPPLPTPPRL
PTEVAGS_3586_PE1
NOISO
XXX------XXXXXXDNN
I
Y
E
V
M
P
S
P
VF
L
V
S
P
LSGTGFTNG---------LTAPPLPPPL
RAT1_PE1018
NOISO
EVN------MSPESGDSN
I
Y
E
V
M
P
S
P
VF
L
V
S
P
ISDTEPGNP------PVSLP---PPASQ
MATCH
CONSENSUS
??????????????????IYEV?PSP??L?SP????????????????????????????
AILMEGL193124_1_PE32
NOISO
QPEP
E
NHPTSSSLPPQ
D
L
L
N
P
DS
A
P
Y
C
Q
L
M
P
TP
BOVIN18_53_PE11
NOISO
VPQP
E
NHP-----Y-Q
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TP
CALJA22_36_PE71
ENSCJAG00000013193
QAGP
E
NHQ-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
CALJA22_36_PE72
ISOFORMIN
QAGP
E
NHQ-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
CANFA1_116_PE19
NOISO
QPEP
E
NHPY----QRQ
D
L
L
N
P
DP
D
P
Y
C
Q
L
T
P
TH
CAVPO6_44_PE7
ENSCPOG00000022078
PPES
E
NHH-----YQQ
D
L
L
N
P
NS
A
P
Y
C
Q
L
V
S
MS
CAVPO6_44_PE8
ISOFORMIN
PPES
E
NHH-----YQ-
D
L
L
N
P
NS
A
P
Y
C
Q
L
V
S
MS
CAVPO80_6_PE9
NOISO
PPEP
E
NHH-----Y-Q
D
L
L
N
P
DS
A
P
Y
C
Q
L
V
P
TS
CHOHOGS_693_PE2
NOISO
----
-
-----------
-
-
-
-
-
--
-
-
-
-
-
-
-
-
--
FELCAGS_388_PE2
NOISO
QPLP
E
NHH-----YQ-
-
-
-
-
-
--
-
-
-
-
-
-
-
-
--
GORGO19_43_PE22
ISOFORMIN
QAGP
E
NHQ-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
GORGO19_43_PE23
ENSGGOG00000009234
QAGP
E
NHQ-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
GORGO19_43_PE24
ISOFORMIN
QAGP
E
NHQ-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
HORSE10_16_PE14
NOISO
PPEP
E
SHH-----Y-Q
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
AP
HS19_PE2315
ISOFORMIN
QAEP
E
NHQ-----YQ-
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
HS19_PE2316
ENSG00000186567
QAEP
E
NHQ-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
LOXAF4_4_PE9
NOISO
ELEP
E
NHH-----Y-Q
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
AP
MACMU19_52_PE39
NOISO
----
-
-----------
-
-
-
-
-
--
-
-
-
-
-
-
-
-
--
MONDO4_376_PE10
ISOFORMIN
NQEA
E
GHRYQ------
E
L
Q
D
P
DP
A
P
Y
C
Q
L
A
P
TA
MONDO4_376_PE9
ENSMODG00000020864
NQEA
E
GHRYQ--LSTQ
E
L
Q
D
P
DP
A
P
Y
C
Q
L
A
P
TA
MOUSE7_PE603
NOISO
EPEP
E
HQH-----Y-Q
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
PANTR19_52_PE5
NOISO
QAGP
E
NHQ-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
PIG6_37_PE10
NOISO
APEP
E
NQP-----Y-Q
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
AP
PONPY19_47_PE16
NOISO
QAGP
E
NHQ-----YKQ
D
L
L
N
P
TP
A
P
Y
C
Q
L
V
P
TS
PTEVAGS_3586_PE1
NOISO
QPQP
E
TQH-----YQQ
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TP
RAT1_PE1018
NOISO
EPQP
E
NQH-----Y-Q
D
L
L
N
P
DP
A
P
Y
C
Q
L
V
P
TS
MATCH
CONSENSUS
????E???????????DLLNP??APYCQL?P??
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