Alignment of the gene Family HOG000154674 of HOGENOM

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
AILMEGL193246_1_PE3 NOISO AEFLDDQDTQLCDNCKKEIPVFNFTIHEIHCQRNIGMCPICKEPFPKSDMEGHMATEHCQ BOVIN17_66_PE12 ENSBTAG00000008761 AEFLNDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKCDMETHMATEHCQ BOVIN17_66_PE13 ISOFORMIN AEFLNDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKCDMETHMATEHCQ CALJA9_108_PE25 NOISO AEFLDDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPICKEPFPKSDMETHMAAEHCQ CANFA26_14_PE4 ENSCAFG00000008830 AEFLDDQDTQLCDNCKKEIPVFNFTIHEIHCQRNIGMCPVCKEPFPKSDMESHMATEHCQ CANFA26_14_PE5 ISOFORMIN AEFLDDQDTQLCDNCKKEIPVFNFTIHEIHCQRNIGMCPVCKEPFPKSDMESHMATEHCQ CAVPO115_4_PE9 NOISO AEFLDDQDTRLCGNCKKEIPVFNFTIHEIHCQRNIGVCPICKEPFPKSDMETHMTAEHCQ CHICK15_PE212 ENSGALG00000004802 MAAVTEVQTQLCGNCKKDIPAANFTIHEIHCSRNLEVCRYCKESVPKSEMKNHIESEHVQ CHOHOGS_3501_PE1 NOISO AEFMHDQDTQLCDNCKKEIPVFNFTIHEIHCQRNIGICPVCKEPFPKSDMESHMATEHCQ DASNOGS_3144_PE1 NOISO AEFLHNQDTQLCDNCKKEIPVFNFTIHEIHCHRNIGMCLVCKEPFPKSDMETHVATEHCQ DIPORGS_2952_PE1 NOISO ---------------SKEIPVFNFTIHEIHCQRNIGVCPICKEPFPKSEMEIHMATEHSQ ECHTEGS_3767_PE1 NOISO AEFLDDQDTRLCDNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX FELCAGS_2104_PE1 NOISO ------------------------------------------------------------ GORGO12_117_PE5 NOISO AEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQ HORSE8_21_PE5 NOISO AEFLEDQSTQLCDNCKKDIPVINFTIHELHCRRNIGMCPVCKEPFPKSDMETHMATEHCQ HS12_PE2264 ENSG00000135148 AEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQ HS12_PE2265 ISOFORMIN AEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQ LAMPAGS_432_PE5 NOISO ---------------KKEIPVFNFTIHEIHCQRNIGMCPICKEPFPKSDMETHMATEHCQ LOXAF84_7_PE20 NOISO AEFLDDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKCDMETHMATEHCQ MACEUGS_4452_PE1 NOISO ---------------KREIPMPNFTIHEIHCRRNIGMCHVCKEPVPKSEMKAHVELEHSQ MACMU11_117_PE5 NOISO AEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPICKEPFPKSDMETHMAAEHCQ MICMUGS_1957_PE1 NOISO ---------------KKEIPVFNFTIHEIHCQRNIGMCPVCKEPFPKSDMETHMATEHCQ MONDO3_509_PE7 ISOFORMIN AISKYICSCFVCFCSKREIPTPNFTIHEIHCRRNIGMCHICKEPVPKSEMKTHMESEHSQ MONDO3_509_PE8 ISOFORMIN -ISKYICSCFVCFCSKREIPTPNFTIHEIHCRRNIGMCHICKEPVPKSEMKTHMESEHSQ MONDO3_509_PE9 ENSMODG00000002929 -ISKYICSCFVCFCSKREIPTPNFTIHEIHCRRNIGMCHICKEPVPKSEMKTHMESEHSQ MOUSE5_PE2224 ENSMUSG00000042726 AEFRDDQASRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHMAAEHCQ MOUSE5_PE2225 ISOFORMIN AEFRDDQASRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHMAAEHCQ MYOLUGS_5807_PE3 NOISO AEFLDDQDTQLCDNCKREIPLCNFTIHEIHCQRNIGVCPICKEPFPKSGMETHMATEHCQ OCHPRGS_607_1_PE4 NOISO AEFPDNQDTRLCNNCKKEIPVFNFTIHEIHCQRNIGVCPVCTEPFPKSDMETHMAEEHCQ ORNAN2_2_PE13 ENSOANG00000004805 MAEVGEQETQLCDNCKREIPVPNFTIHEIHCRRNLGICHICKEPIPKSEMKNHMELEHTQ ORNAN2_2_PE14 ISOFORMIN MAEVGEQETQLCDNCKREIPVPNFTIHEIHCRRNLGICHICKEPIPKSEMKNHMELEHTQ ORNAN2_2_PE15 ISOFORMIN MAEVGEQETQLCDNCKREIPVPNFTIHEIHCRRNLGICHICKEPIPKSEMKNHMELEHTQ PANTR12_118_PE6 NOISO AEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQ PIG14_41_PE16 NOISO --FLTFSLIYF--CSKKEIPVFNFTIHEIHCQRNIGMCAICKEPFPKSDMETHMATEHCQ PONPY12_119_PE4 NOISO AEFLDDQEIRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPICKEPFPKSDMETHMAAEHCQ PROCAGS_3263_PE1 NOISO AEFQDDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMETHMATEHCQ PTEVAGS_3824_PE4 NOISO AEFLDDQDTRLCDNCKKEIPACNFTIHEIHCLRNIGMCPVCKEPFPKSDMETHMATEHCQ RABIT21_9_PE5 NOISO AELLDDQDTQLCNNCKKEIPVFNFTIHEIHCQRNIGVCPVCTEPFPKSDMETHVATEHCQ RAT12_PE720 NOISO AEFPDDQAARLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHVATEHCQ SORAR140962_PE1 NOISO ------------------------------------------------------------ SPETRGS_2491_PE1 NOISO ------------------------------------------------------------ TARSY42503_PE1 NOISO ------------------------------------------------------------ TUPGBGS_5528_PE3 NOISO AEFLQDQDTRLCDNCQKEIPVFNFTIHEIHCQRNIDMCPICKEPFPKSDMETHMASEHCQ TURTRGS_415_PE5 NOISO AEFLDGQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPICKEPFPKSDMETHMATEHCQ MATCH CONSENSUS AEFLDDQ?T?LCDNCKKEIPVFNFTIHEIHCQRNIGMCP?CKEPFPKSDMETHMA?EHCQ

AILMEGL193246_1_PE3 NOISO VTCKCNKKLEKRQLKKHEETDCPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGNC BOVIN17_66_PE12 ENSBTAG00000008761 VTCKCNKKLEKRQLKKHEVSFPVPYYRAACRAESQSCGVFVLRQHQ-AHCLTRGRICVLC BOVIN17_66_PE13 ISOFORMIN VTCKCNKKLEKRQLKKHEIYVCNVC-MCVCVYVCVYVYVYILNEHKHIHQLINPNNCSVI CALJA9_108_PE25 NOISO VTCKCNKELEKRLLKKHEETECPLR-LAVCQHCDLELSILKLKEHE-DYCGARTELCGNC CANFA26_14_PE4 ENSCAFG00000008830 VTCKCNKKLEKRQLKKHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGSC CANFA26_14_PE5 ISOFORMIN VTCKCNKKLEKRQLKKHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGSC CAVPO115_4_PE9 NOISO VTCKCNKKFEKMQLKKHEETECPLR-LAVCQHCDLELSVLKLKEHE-DYCGARTELCSSC CHICK15_PE212 ENSGALG00000004802 VTCKCSMKVEKSLLEDHETSACPLR-PAVCQHCDIQLTFNKLQDHE-SYCGARTEMCSGC CHOHOGS_3501_PE1 NOISO VICKCNKKLEKRQLKKHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGSC DASNOGS_3144_PE1 NOISO VTCKCNKKLEKRQLKKHEETECPLR-LAVCQHCDLELSVLKLKDHE-DYCGARTELCGSC DIPORGS_2952_PE1 NOISO XXXXXXXXXXXXXXXXXXETDCPLR-LALCQHCDLELAVLKLKEHE-EYCGARTEPCGSC ECHTEGS_3767_PE1 NOISO XXXXXXXXXXXXXXXXXXETECPLR-PALCQHCDLELSVLRLKEHE-DYCGARTERCGNC FELCAGS_2104_PE1 NOISO -----NRKLEKRQL-KHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGNC GORGO12_117_PE5 NOISO VTCKCNKKLEKRLLKKHEETECPLR-LAVCQHCDLELSILKLKEHE-DYCGARTELCGNC HORSE8_21_PE5 NOISO VTCKCNKKLEKRQLKKHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGTC HS12_PE2264 ENSG00000135148 VTCKCNKKLEKRLLKKHEETECPLR-LAVCQHCDLELSILKLKEHE-DYCGARTELCGNC HS12_PE2265 ISOFORMIN VTCKCNKKLEKRLLKKHEETECPLR-LAVCQHCDLELSILKLKEHE-DYCGARTELCGNC LAMPAGS_432_PE5 NOISO VTCKCNKKLEKRQLKKHEEIECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGNC LOXAF84_7_PE20 NOISO VTCKCNKKLEKRQLKTHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGSC MACEUGS_4452_PE1 NOISO VACKCNMKMERRQLTNHE--ECPLR-LAVCQHCELELAFLKLKDHE-DYCGARTELCGKC MACMU11_117_PE5 NOISO VTCKCNKKLEKRLLKKHEETECPLR-LAVCQHCDLELSILKLKEHE-DYCGARTELCGNC MICMUGS_1957_PE1 NOISO VTCKCNKKLEKRQLKKHEETECPLR-LALCQHCDLELSILKLKEHE-DYCGARTELCGTC MONDO3_509_PE7 ISOFORMIN VTCKCNMKMERRQLTNHEALECPLR-LAVCQHCELELAFLKLKDHE-DYCGARTELCGKC MONDO3_509_PE8 ISOFORMIN VTCKCNMKMERRQLTNHEALECPLR-LAVCQHCELELAFLKLKDHE-DYCGARTELCGKC MONDO3_509_PE9 ENSMODG00000002929 VTCKCNMKMERRQLTNHEALECPLR-LAVCQHCELELAFLKLKDHE-DYCGARTELCGKC MOUSE5_PE2224 ENSMUSG00000042726 VTCKCNKKLEKRQLKQHAETECPLR-LAVCQHCDLELSVVKLKEHE-DYCGARTELCGSC MOUSE5_PE2225 ISOFORMIN VTCKCNKKLEKRQLKQHAETECPLR-LAVCQHCDLELSVVKLKEHE-DYCGARTELCGSC MYOLUGS_5807_PE3 NOISO VTCKCNKKLEKRQLQNHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGNC OCHPRGS_607_1_PE4 NOISO VTCKCNKKLERRLLKQHEETECPLR-LAVCQHCDLELCVLKLKEHE-EYCGARTELCGSC ORNAN2_2_PE13 ENSOANG00000004805 VTCKCNMKLEKWQLKNHEDLECPLR-LVVCQHCELELSFVKVKDHE-DYCGARTELCRGC ORNAN2_2_PE14 ISOFORMIN VTCKCNMKLEKWQLKNHEDLECPLR-LVVCQHCELELSFVKVKDHE-DYCGARTELCRGC ORNAN2_2_PE15 ISOFORMIN VTCKCNMKLEKWQLKNHEDLECPLR-LVVCQHCELELSFVKVKDHE-DYCGARTELCRGC PANTR12_118_PE6 NOISO VTCKCNKKLEKRLLKKHEETECPLR-LAVCQHCDLELSILKLKEHE-DYCGARTELCGNC PIG14_41_PE16 NOISO VTCKCNKKLEKRQLKKHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGSC PONPY12_119_PE4 NOISO VTCKCNKKLEKRLLKKHEETECPLR-LAVCQHCDLELSILKLKEHE-DYCGARTELCGNC PROCAGS_3263_PE1 NOISO VTCKCNKKLEKRQLKTHEETECPLR-LALCQHCDLELSILKLKDHE-DYCGARTELCGSC PTEVAGS_3824_PE4 NOISO VTCKCNKKLEKRHLKNHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGSC RABIT21_9_PE5 NOISO VTCKCNKKLERRQLKKHEESECPLR-LAVCQHCDLELSVLKLKEHE-DYCGARTELCGSC RAT12_PE720 NOISO VTCKCNKKLEKRQLKQHVETECPLR-LAVCQHCDLELSVVKLKEHE-DYCGARTELCGSC SORAR140962_PE1 NOISO ------------------EAECPLR-PARCQHCELELAVVRLQEHE-EYCGARTELCGTC SPETRGS_2491_PE1 NOISO ------------------ETECPLR-LAVCQHCDLELSVLKLKEHE-DYCGARTELCGNC TARSY42503_PE1 NOISO ------------------ETECPLR-LALCQHCDLELSILKLKEHE-DYCGARTELCGNC TUPGBGS_5528_PE3 NOISO VTCKCNKKLEKRQLKNHAETECPLR-LALCQHCDLELSILKLKEHE-DYCGARTELCGSC TURTRGS_415_PE5 NOISO VTCKCNKKLEKRQLKKHEETECPLR-LALCQHCDLELSVLKLKDHE-DYCGARTELCGNC MATCH * . :.:*: : . . * CONSENSUS VTCKCNKKLEKRQLKKHEETECPLR?LAVCQHCDLELSVLKLKDHE?DYCGARTELCG?C

AILMEGL193246_1_PE3 NOISO G-RNVLVKDLKTHPEVCGRDGEEKRDEVAMPPNAY--DESWGQDGIWIASQLLRQIEALD BOVIN17_66_PE12 ENSBTAG00000008761 IGRGILHH-LTTSPYICMSNISSKGKEKA--MAPHSSTLAWKIDLAAVA-AAVRQYSCLE BOVIN17_66_PE13 ISOFORMIN LKEQKIKPVLYTNVQIKKVSVFLKDNHFSSLPGSSKGKLVWGGGSDKHM-GIA--LLLLF CALJA9_108_PE25 NOISO G-RNVLVKDLKTHPEVCGREGEEKRNEVAIPSNAY--DESWGQDGIWIASQLLRQIEALD CANFA26_14_PE4 ENSCAFG00000008830 G-RNVLVKDLKTHPEVCGRFGEEKKDEVAVPPNAY--DESWGQDGIWIASQLLRQIEALD CANFA26_14_PE5 ISOFORMIN G-RNVLVKDLKTHPEVCGRFGEEKKDEVAVPPNAY--DESWGQDGIWIASQLLRQIEALD CAVPO115_4_PE9 NOISO G-RNVLVKDLKTHPAVCGRGEEESRNQAAGAPAAC--DESRGQDGMWAASQLLRHIEALD CHICK15_PE212 ENSGALG00000004802 G-LNIMVKDLKEHPQVCGKEAKRVSKTVP--H--F-----EGEDAGLHALRDIRNQLRSD CHOHOGS_3501_PE1 NOISO G-RNILVKDLKTHPAVCGREGEEKRNEVVIPPDAY--DESWSQDGIWIASHLLRQIEALN DASNOGS_3144_PE1 NOISO G-RNVLVKDLKTHLEVCGREGEEKRDEVAMPPDAY--DESWNQDGIWIASQLLRQIEALD DIPORGS_2952_PE1 NOISO G-RNVLVKDLKTHPAVCGREEVEKRNTTAMSPNAY--DEAWGQDRIWIASQLLRQIESLD ECHTEGS_3767_PE1 NOISO G-RNVLVKDLKTHPGVCGQEGKEKEDPVALPPNAA--ADPWGQHGMWIASHLFRQMEALD FELCAGS_2104_PE1 NOISO G-RNVLVKDLKTHPEVCGRDGEEKRDEVAMPPNAY--DESWGQDGIWIASQLLRQIEALD GORGO12_117_PE5 NOISO G-RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAY--DESWGQDGIWIASQLLRQIEALD HORSE8_21_PE5 NOISO G-RNVLVKDLKTHPEVCGRDEEEKKDEADVPPNAY--DESWGQDGIWIASQLLRQIEALD HS12_PE2264 ENSG00000135148 G-RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAY--DESWGQDGIWIASQLLRQIEALD HS12_PE2265 ISOFORMIN G-RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAY--DESWGQDGIWIASQLLRQIEALD LAMPAGS_432_PE5 NOISO G-RNVLVKDLKTHPDVCGRDGQEKRDEVAMPSNAY--DESWGQDGIWIASQL-RQMEALD LOXAF84_7_PE20 NOISO G-RNVLVKDRKTHPEVCGKDGEEKREVVALPPNAD--DELWRQDGMWTASHL-RQIDALV MACEUGS_4452_PE1 NOISO G-RNIMVKDLKTHPEVCGREAEEKREARTRPLHGY---EGT-RDGAWFIAQV-FRMLGPE MACMU11_117_PE5 NOISO G-RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAY--DESWGQDGIWIASQLLRQIEALD MICMUGS_1957_PE1 NOISO G-RNVLVKDLKTHPEVCGRDGEEKRNEVAIPPNAY--DESWGQDGIWIASQLLRQIETLD MONDO3_509_PE7 ISOFORMIN G-RNVMVKDLQAHPEVCGREGEEKRESRSRPSHGY---E------TWFIAQTVQNLLGPE MONDO3_509_PE8 ISOFORMIN G-RNVMVKDLQAHPEVCGREGEEKRESRSRPSHGY---E------TWFIAQTVQNLLGPE MONDO3_509_PE9 ENSMODG00000002929 G-RNVMVKDLQAHPEVCGREGEEKRESRSRPSHGY---E------TWFIAQTVQNLLGPE MOUSE5_PE2224 ENSMUSG00000042726 G-RNVLVKELKTHPEVCGRVEEEKRTEAAIPPEAY--DEPWSQDRIWIASQLLRQIEALD MOUSE5_PE2225 ISOFORMIN G-RNVLVKELKTHPEVCGRVEEEKRTEAAIPPEAY--DEPWSQDRIWIASQLLRQIEALD MYOLUGS_5807_PE3 NOISO G-RNVLVKDLKTHPEVCRRDGEKKRDEAAVPPNAY--DVSWGQDGIWIASQLLRQIESLD OCHPRGS_607_1_PE4 NOISO G-RNVLVKDLKTHPDVCGREGEEKRNDVAVSPHAYDYDAAFGQDGMWVASQLLRQIEALE ORNAN2_2_PE13 ENSOANG00000004805 G-RNVMVKDLKAHPEVCGKEEEEKREARSRPRPNY---ENEGADEAWFVSQTIKNLLGPE ORNAN2_2_PE14 ISOFORMIN G-RNVMVKDLKAHPEVCGKEEEEKREARSRPRPNY---ENEGADEAWFVSQTIKNLLGPE ORNAN2_2_PE15 ISOFORMIN G-RNVMVKDLKAHPEVCGKEEEEKREARSRPRPNY---ENEGADEAWFVSQTIKNLLGPE PANTR12_118_PE6 NOISO G-RNVLVKDLKTHPEVCGREGEEKRNEVAIPSNAY--DESWGQDGIWIASQLLRQIEALD PIG14_41_PE16 NOISO G-RNVLVKDLKTHPEVCGRNEEEKRDEVTMLPNAY--DDSWGQDGIWIASQL-RQIEALD PONPY12_119_PE4 NOISO G-RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAY--DESWGQDGIWIASQLLRQIEALD PROCAGS_3263_PE1 NOISO G-RNVLVKDLKTHPEVCGREGEEKRDAGAPPPNAD--AEPWGADGMWMASHLLRHMEALD PTEVAGS_3824_PE4 NOISO G-RNVLVKDLKTHPEVCGRDGEEKRD-VAVPLNAY--DESWGD-EIWIASQL-RQIESLS RABIT21_9_PE5 NOISO G-RNVLVKDLKTHPDICGREGEEKRNEVAIPPQAY--DESFDQDGIWIASQLLRQIEALD RAT12_PE720 NOISO G-RNVLVKELQTHPAVCGRVEEEKRSEAAVPPEAY--DEPWSQDRIWIASQLLRQIEALD SORAR140962_PE1 NOISO G-RNVLVKDLKAHPAVCGQAGEAKRAEAPPSPDTY--DAPWAQDGIWIASQLLRQIEALD SPETRGS_2491_PE1 NOISO G-RNVLVKDLKSHPEVCGRGEEERRNEVTVSPNAY--DESWGQDGIWIASQLLRQIEALD TARSY42503_PE1 NOISO G-RNVLVKDLKTHPEVCGREGEEKRNEIAIPSNAY--DESWGQDGVWIASQLLRQIEALD TUPGBGS_5528_PE3 NOISO G-RNILVKDLKTHPEVCGREAEEKRNEVAIPPNAY--DEPWGQDGIWIASQLLRQIEALD TURTRGS_415_PE5 NOISO G-RNVLVKDLKTHPEVCGRDVEEKRDEVAMPPNAY--DDSWGQDGIWIASQL-RQIEALD MATCH : : CONSENSUS G?RNVLVKDLKTHPEVCGREGEEKR?EVA?PPNAY??DESWGQDGIWIASQLLRQIEALD

AILMEGL193246_1_PE3 NOISO PPMRLPRRPLRAFESDLFHS----R--TTNQRNMTAQFPIQNNLLEEQERQERNRTRRPP BOVIN17_66_PE12 ENSBTAG00000008761 NPMDGGACPTGSLVHGIFQA---R---IQNTCKMHSTVPVSYPSVEEQERQERNRSRQTP BOVIN17_66_PE13 ISOFORMIN ------APGLGWLILGSFEF---NSFSSQNSFLRTSCCLFFPPSVEEQERQERNRSRQTP CALJA9_108_PE25 NOISO PPMRLPGRPLRAFESDVFHN----R--TTNQRNITSQVSIQNNLFEEQERQERNRGRQPP CANFA26_14_PE4 ENSCAFG00000008830 PPMRIPRRPMRAFESDLFHS----R--TTNQRNMTAQFPIQNNLLEEQERQEKNRTRQAS CANFA26_14_PE5 ISOFORMIN PPMRIPRRPMRAFESDLFHS----R--TTNQRNMTAQFPIQNNLLEEQERQEKNRTRQAS CAVPO115_4_PE9 NOISO PPTRLPRRPLRAFESDLFHN----R--TANQRNVTARFPVQNNLLVEEQMQEKDRGQKLP CHICK15_PE212 ENSGALG00000004802 NCAGPLWRMPRVLERQTYSSCVGDRTLKDISRRNVSRTQRNQNQEYGLEQLE--RNKNIN CHOHOGS_3501_PE1 NOISO SPMRLPRRHLQSFESDLFQS----R--TTNQRNVTSQFPIQNNLXXXXXXXXXXXXXXXX DASNOGS_3144_PE1 NOISO PPMRLPQRHLRSFESDLLHN----R--TTTQRNVTSQFPIQNNLFEEQEMQERNRSHQPP DIPORGS_2952_PE1 NOISO PPVRLSSRPLRSLESDSVHS----R--TSSQRNVPAHFPIQNNLFEEQERQERNRSQQPP ECHTEGS_3767_PE1 NOISO PPMRLPRRPLQCFDAELLHS----R--TTNQRNMATQFPIQNNLXXXXXXXXXXXXXXXX FELCAGS_2104_PE1 NOISO PPMRLPRRPLRAFDLDLFHS----R--TTNQRNMTAHFPIQNNLLEEQERQERNRTRQPP GORGO12_117_PE5 NOISO PPMRLPRRPLRAFESDVFHN----R--TTNQRNITAQVSIQNNLFEEQERQERNRGQQPP HORSE8_21_PE5 NOISO PPMRLPRRPLRAFESDLFRN----R--TTSQRSTTAPFLVQNNLLEEQERQERNRSRQPR HS12_PE2264 ENSG00000135148 PPMRLPRRPLRAFESDVFHN----R--TTNQRNITAQVSIQNNLFEEQERQERNRGQQPP HS12_PE2265 ISOFORMIN PPMRLPRRPLRAFESDVFHN----R--TTNQRNITAQVSIQNNLFEEQERQERNRGQQPP LAMPAGS_432_PE5 NOISO PPIRLPRRPLRAFESDLFHT----R--TTNQRSVTARFPIQNNLLEEQERQERNRSRRTP LOXAF84_7_PE20 NOISO PPMRLPRRHLRSFESDLVHS----R--TTSQRNMPTQFPIQNNLLEEQERQERNRSRQPP MACEUGS_4452_PE1 NOISO NPTKPLRRPSRSFEK--------------------------------QERRTGSKNQLYP MACMU11_117_PE5 NOISO PPMRLPQRPLRAFESDVFHD----R--TTNQRNITAQVSIQNNLFEEQERQERNRGQQPP MICMUGS_1957_PE1 NOISO PPMRLPRRPLRAFESDLFHN----R--TTNQRNMAAQFPIQNNLMLPS------------ MONDO3_509_PE7 ISOFORMIN NPTRPLRRLSRSLENPFYSHLIVDQMARNPNRGAGSAMQLDQNRGEEQERQKGNKSKRSP MONDO3_509_PE8 ISOFORMIN NPTRPLRRLSRSLENPFYSHLIVDQMARNPNRGAGSAMQLDQNRGEEQERQKGNKSKRSP MONDO3_509_PE9 ENSMODG00000002929 NPTRPLRRLSRSLENPFYSHLIVDQMARNPNRGAGSAMQLDQNRGEEQERQKGNKSKRSP MOUSE5_PE2224 ENSMUSG00000042726 PPMRLPGRPLQAFEADPFYS----R--TTSQRSMAAQFPVQNNLFEEQERQERNRSRQSP MOUSE5_PE2225 ISOFORMIN PPMRLPGRPLQAFEADPFYS----R--TTSQRSMAAQFPVQNNLFEEQERQERNRSRQSP MYOLUGS_5807_PE3 NOISO PPMRLPRRPLRASESELSHS----R--TTNQRNMTTQFPIQNNLLEEQERQERNRSQQSP OCHPRGS_607_1_PE4 NOISO PPVRIPRRPLRDFGSDLFHN----R--TANQRNVSTQFPIQNNLFEEQQRQERNRSRQPL ORNAN2_2_PE13 ENSOANG00000004805 DPTRPLRRLPRPLENRFCSHLSVDEFFRSANRRNVSAVPVDQNLADEQGRLERNKTNLPS ORNAN2_2_PE14 ISOFORMIN DPTRPLRRLPRPLENRFCSHLSVDEFFRSANRRNVSAVPVDQNLADEQGRLERNKTNLPS ORNAN2_2_PE15 ISOFORMIN DPTRPLRRLPRPLENRFCSHLSVDEFFRSANRRNVSAVPVDQNLADEQGRLERNKTNLPS PANTR12_118_PE6 NOISO PPMRLPRRPLRAFESDVFHN----R--TTNQRNITAQVSIQNNLFEEQERQERNRGQQPP PIG14_41_PE16 NOISO PPMRLPRRPLRAFESDLFQS----R--TTSQRSVTAQFPIQNNLLEEQESQERNRRRQTP PONPY12_119_PE4 NOISO PPMRLPRRPLRAFESDVFHS----R--TTNQRNITAQVSIQNNLFEEQERQERNRGQQPP PROCAGS_3263_PE1 NOISO PPTRLPRRRPRSFESDLIHS----R--TASQRNMTTQFPIQNNLLEEQERQERNRGRQPP PTEVAGS_3824_PE4 NOISO P-MR--LRRLRTFESDFSLS----R--TTNQRSMTTQFPIQNNLLEEQERQERNRSRQPS RABIT21_9_PE5 NOISO PPVRIPRRPLRDFGSDFFHN----R--TTNQRNMPPQFPIQNNLFEEQERQERNRSRQPL RAT12_PE720 NOISO PPMRLPGRPLRAFEADPFYS----R--TASQRGVTAHFPIQNNLFEEQERQERNRSHQSP SORAR140962_PE1 NOISO PPTRLSRRPLRDFESDLFHG---G---TPERRDVGSQFPGHSGRXXXXXXXXXXXXRQPG SPETRGS_2491_PE1 NOISO PPMRLPRRPLRAFESDLFHN----R--TANQRNMTAPFPIQNNLFEEQERQERNRSRQPP TARSY42503_PE1 NOISO T----PRRPMGAFESDLFHS---NR--IISQRNMTAQFPVQNNLFEEQERQERNRGRQPH TUPGBGS_5528_PE3 NOISO PPMRLPGTPLRTFDSDLFHN----R--TTNQRNMTTQFPIQNNLXXXXXXXXXXXXXXXX TURTRGS_415_PE5 NOISO PPMRLPRRPLRAFESELFQS----R--TTNQRSMTAQFPIQNNLLEEQERQERNRSRQTL MATCH CONSENSUS PPMRLPRRPLRAFESD?FH?????R??TTNQRN?TAQFPIQNNL?EEQERQERNR??QPP

AILMEGL193246_1_PE3 NOISO KEGGEDNANLDFMLALSLQNEGQARSV----AEQDFWRAVCGADQSV-EGSNALNDMKGA BOVIN17_66_PE12 ENSBTAG00000008761 KERGEDSANLDFMLALSLQNEGQAPTL----AEQDFWRVIYEADQSR-EGPSALNDIRGA BOVIN17_66_PE13 ISOFORMIN KERGEDSANLDFMLALSLQNEGQAPTL----AEQDFWRVIYEADQSR-EGPSALNDIRGA CALJA9_108_PE25 NOISO KEGGEDSANLDFMLALSLQNEGQASSM----AEQDFWRAVCEADQSH-GGPSSLSDIKGA CANFA26_14_PE4 ENSCAFG00000008830 KEGGEDSANLDFMLALSLQNEGQARSV----AEQDFWRAVCGAEQSF-EGSSALNDMKGA CANFA26_14_PE5 ISOFORMIN KEGGEDSANLDFMLALSLQNEGQARSV----AEQDFWRAVCGAEQSF-EGSSALNDMKGA CAVPO115_4_PE9 NOISO PKGGEDTANLDFMLALSLQNEGQTPSV----AEQDFWRAVCEADPCH-GVAQFRSDAKGT CHICK15_PE212 ENSGALG00000004802 SLYEEQNANLDHMLALSLQNENNPRNNTAAEIHRDVWENRYAKENSFQ--LNSLE--QYK CHOHOGS_3501_PE1 NOISO XXXXXXXXXXXXXXXXXXX-XXXXXSN----VVESFWTAICEADQPH-GGPSALSDIKGA DASNOGS_3144_PE1 NOISO KEGGEDSANLDFMLALSLQNEGQVSNM----AEQSFWRTICEADQPH-GGPSALNDLKGE DIPORGS_2952_PE1 NOISO TKSGEDSANLDFMLALSLQSEGQASSL----AEQDFWQAVCEAEQLH-SGPGSLIDRKGA ECHTEGS_3767_PE1 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXX-XXXXXXXXXXXA FELCAGS_2104_PE1 NOISO KEGGEDSANLDFMLALSLQNEGQAHSM----AEQDFWRAVCGADQSL-EGPNALNDIKGT GORGO12_117_PE5 NOISO KEGGEESANLDFMLALSLQNEGQASSV----AEQDFWRAVCEADQSH-GGPRSLSDIKGA HORSE8_21_PE5 NOISO KEVGEDSADLDFMLALSLQNEGQAPRV----AEQDFWRSIWEADQSR-GGPSTLNDIKGA HS12_PE2264 ENSG00000135148 KEGGEESANLDFMLALSLQNEGQASSV----AEQDFWRAVCEADQSH-GGPRSLSDIKGA HS12_PE2265 ISOFORMIN KEGGEESANLDFMLALSLQNEGQASSV----AEQDFWRAVCEADQSH-GGPRSLSDIKGA LAMPAGS_432_PE5 NOISO KEGGEDSANLDFMLALSLQNEGQAPSM----AEQDFWRVICEADQSR-EGPNALDDIRGA LOXAF84_7_PE20 NOISO KEGGEDSANLDFMLALSLQNEGQAPHM----AEQDFWRAVCEADQSR-GGPRALSDIKGA MACEUGS_4452_PE1 NOISO PGPGEEDAHLDYMLALSLQSESSAPAA-----QQDFWRAVYT---------------EDA MACMU11_117_PE5 NOISO KEGGEDSANLDFMLALSLQNEGQASSV----AEQDFWRAVCEADQSH-GGPSSLSDIKGA MICMUGS_1957_PE1 NOISO -----------------LGLEILASST----AQQDFWRAVYEADQSH-GGPSSLSDIKXX MONDO3_509_PE7 ISOFORMIN TVSGEEDAHLDYMLALSLQSESSVPSG-ATTHLEDFWRAVSCLDPWMVQ-PSGAQANQGS MONDO3_509_PE8 ISOFORMIN TVSGEEDAHLDYMLALSLQSESSVPSG-ATTHLEDFWRAVCAEDLGPTG-NRSVSCYLFA MONDO3_509_PE9 ENSMODG00000002929 TVSGEEDAHLDYMLALSLQSESSVPSG-ATTHLEDFWRAVCAEDLATEG-PNELKKIILC MOUSE5_PE2224 ENSMUSG00000042726 KDSAENNAHLDFMLALSLQNEGQATSM----VEQGFWESVPEADPAR-AGPTSLGDIKGA MOUSE5_PE2225 ISOFORMIN KDSAENNAHLDFMLALSLQNEGQATSM----VEQGFWESVPEADPAR-AGPTSLGDIKGA MYOLUGS_5807_PE3 NOISO IEGGEDSSNLDFMLALSLQNEGQAPKL----AEQDFWRAVCEAEQSL-GGPKSLNDIKGA OCHPRGS_607_1_PE4 NOISO KEVGEDTANLDFMLALSLQSEGQPSSL----SEQDFWRAICETDQPH-GTAHSQSDIKGA ORNAN2_2_PE13 ENSOANG00000004805 PIYGDENSHLDYMLALSLQNESSLHSSSLNPEIENFWTALYRKDSSPSRGFSRAQDKEGA ORNAN2_2_PE14 ISOFORMIN PIYGDENSHLDYMLALSLQNESSLHSSSLNPEIENFWTALYRKDSSPSRGFSRAQV-AAT ORNAN2_2_PE15 ISOFORMIN PIYGDENSHLDYMLALSLQNESSLHSSSLNPEIENFWTALYRKDSSPSRGFSRAQ----- PANTR12_118_PE6 NOISO KEGGEESANLDFMLALSLQNEGQASSV----AEQDFWRAVCEADQSH-GGPRSLSDIKGA PIG14_41_PE16 NOISO KEGGEDSANLDFMLALSLQNEGQPPNM----AEQDLWRVVCEADQSH-EGPSALNDIRGA PONPY12_119_PE4 NOISO KEGGEDSANLDFMLALSLQNEGQASSV----AEQDFWRAVCEADQSH-GGPSSLSDIKGA PROCAGS_3263_PE1 NOISO KEGGEDSANLDFMLALSLQNEGQVPHM----AEQDFWRAICEADQSR-GGPSALSDIKGA PTEVAGS_3824_PE4 NOISO KEGGEDSANLDFMLALSLQNEGQAPSM----AERDFWRATYEADQSH-EGHRALNDIKGA RABIT21_9_PE5 NOISO KEGGEDSANLDFMLALSLQNEGQSSSL----AEQDFWRAICEADQPH-GGPASLNDIKGA RAT12_PE720 NOISO KDSAENSAHLDFMLALSLQNEGQASSM----VEQGFWESVPEADPAR-AGPTSLGDIKGA SORAR140962_PE1 NOISO -VGG--DSATDYMLAL--LQSGQLPSV----AEQGFWRAVCEVGQSR-AGPSAPGSDAGA SPETRGS_2491_PE1 NOISO KEGGEDSANLDFMLALSLQNEGQASTV----AEQDFWRAVCEADQSH-GGPSSLSDMKGA TARSY42503_PE1 NOISO KKGGEDSANLDFMLALSLQNEGQASSM----AEQDFWKAVCEADQSH-GGPSSLRDIKGA TUPGBGS_5528_PE3 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXX-XXXXXXXXXXXT TURTRGS_415_PE5 NOISO KEGGEDSANLDFMLALSLQNEGQAPNL----AEQDFWRVICEADQSH-EGPGALNDIRGA MATCH CONSENSUS KEGGEDSANLDFMLALSLQNEGQA?S?????AEQDFWRAVCEADQS???GP??L?DIKGA

AILMEGL193246_1_PE3 NOISO ADRTMLPCEFCEELYPEELLIDHQTSCNPSCALPSLSMGNTSPKGV-E-----DPDVIFQ BOVIN17_66_PE12 ENSBTAG00000008761 VDETMLPCEFCEELYPEELLIDHQTSCNPSCALPPLSVGSTSPRGV-E-----DPDAIFQ BOVIN17_66_PE13 ISOFORMIN VDETMLPCEFCEELYPEELLIDHQTSCNPSCALPPLSVGSTSPRGV-E-----DPDAIFQ CALJA9_108_PE25 NOISO ADETMLPCEFCEELYPEELLIDHQTSCNPSRALPSFTTGSSSPRGV-E-----EPDVIFQ CANFA26_14_PE4 ENSCAFG00000008830 ADRTMLPCEFCEELYPEELLIDHQTSCNPSCALPSLNMGSTSPRGV-E-----DPDVIFQ CANFA26_14_PE5 ISOFORMIN ADRTMLPCEFCEELYPEELLIDHQTSCNPSCALPSLNMGSTSPRGV-E-----DPDVIFQ CAVPO115_4_PE9 NOISO ADETMLPCEFCEELYPEELLIDHQTSCNRSRALPLLSTGSSPPRRV-E-----DPDVVFQ CHICK15_PE212 ENSGALG00000004802 GDEIMLPCEFCEELYPAEDLILHQTGCNPASAFASFSKRGSLDPQKYD-----DLHNIG- CHOHOGS_3501_PE1 NOISO AEETMLPCEFCEELYPEELLIDHQTSCNPSCALPLLSTGSSSPRGV-E-----DPDVIFQ DASNOGS_3144_PE1 NOISO ADETMLPCEFCEELYPEELLIDHQTSCNPSRALPLLSTGSSSLRGV-E-----DPDVIFQ DIPORGS_2952_PE1 NOISO ADETMLPCEFCEELYPEDLLIDHQTSCNPSRALPSLGPDSSSSSRV-E-----DPGDLFQ ECHTEGS_3767_PE1 NOISO AGETLLPCEFCEELYPEELLIDHQTSCNPSCALPPFSTGRSSPKVM-E-----RPDNVFQ FELCAGS_2104_PE1 NOISO ADRTMLPCEFCEELYPEKLXXXXXTSCNPSCALPSLSMGSTPPKEV-E-----DPDVIFQ GORGO12_117_PE5 NOISO ADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGV-E-----EPDVIFQ HORSE8_21_PE5 NOISO ADDTMLPCEFCEELYPEELLIDHQTSCNPSCALPSLNVGSPSPKGV-E-----DPDVIFQ HS12_PE2264 ENSG00000135148 ADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGV-E-----EPDVIFQ HS12_PE2265 ISOFORMIN ADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGV-E-----EPDVIFQ LAMPAGS_432_PE5 NOISO ADETMLPCEFCEELYPEDLLIDHQTSCNPPCALPPLSVGRTSPKGV-E-----DPEVIFQ LOXAF84_7_PE20 NOISO AGETMLPCEFCEELYPEELLIDHQTSCNPSCALPPLSTGSSPLKVV-E-----DPDVIFQ MACEUGS_4452_PE1 NOISO ANETMLPCEFCEELYPEEDLILHQTGCNPTSAVASFSKRSSPPRGPG-------GPEVNF MACMU11_117_PE5 NOISO ADETMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGV-E-----EHDVIFQ MICMUGS_1957_PE1 NOISO XXXXXXXXXXXXXXXXXXXXXXXXTSCNPSCALPSFNTGSSSPRGV-E-----EPDVIFQ MONDO3_509_PE7 ISOFORMIN DNETMLPCEFCEELYPEEDLILHQTGCNPASALASFGKRSSPPSLSQDRGDRENHEDQFQ MONDO3_509_PE8 ISOFORMIN DNETMLPCEFCEELYPEEDLILHQTGCNPASALASFGKRSSPPSLSQDRGDRENHEDQFQ MONDO3_509_PE9 ENSMODG00000002929 VDETMLPCEFCEELYPEEDLILHQTGCNPASALASFGKRSSPPSLSQDRGDRENHEDQFQ MOUSE5_PE2224 ENSMUSG00000042726 ADEILLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGV-E-----DPGTIFQ MOUSE5_PE2225 ISOFORMIN ADEILLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGV-E-----DPGTIFQ MYOLUGS_5807_PE3 NOISO ADETMLPCEFCEELYPEELLIDHQTSCNPSSALPSFNMGSTSLKEVEE-----DPDVIFQ OCHPRGS_607_1_PE4 NOISO ADETVLPCEFCEELYPEELLLDHQTSCNPSRALPSLNAGSSSPRGM-E-----DSDVIFQ ORNAN2_2_PE13 ENSOANG00000004805 DYKTMLPCEFCEELYPEEDLILHQTGCNPASVLASFRKRSSSPSPQRD------HAGHFR ORNAN2_2_PE14 ISOFORMIN DYKTMLPCEFCEELYPEEDLILHQTGCNPASVLASFRKRSSSPSPQRD------HAGHFR ORNAN2_2_PE15 ISOFORMIN DYKTMLPCEFCEELYPEEDLILHQTGCNPASVLASFRKRSSSPSPQRD------HAGHFR PANTR12_118_PE6 NOISO ADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGV-E-----EPDVIFQ PIG14_41_PE16 NOISO ADGTMLPCEFCEELYPEELLIDHQTSCNPSCALPPLGVGSTSPKGM-E-----DPDVIFQ PONPY12_119_PE4 NOISO ADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGV-E-----EPDVIFQ PROCAGS_3263_PE1 NOISO TGETMLPCEFCEELYPEELLIDHQTSCNPSCALPPLTMGSSPPKVV-E-----DPDVIFQ PTEVAGS_3824_PE4 NOISO ADETMLPCEFCEELYPEELLIDHQTTCNSSCALPSFNMGSTSPKGV-E-----DSDVIFQ RABIT21_9_PE5 NOISO ADETVLPCEFCEELYPEELLIDHQTSCNPSRAFPSLSTDSSSPRGM-Q-----DSDVIFQ RAT12_PE720 NOISO ADETLLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGV-E-----DPGAIFQ SORAR140962_PE1 NOISO DVETMLPCEFCEELYPEELFIDHQTSCNPSCSLPPLTVGSPSPRGV-E-----DPDVIFQ SPETRGS_2491_PE1 NOISO ADETMLPCEFCEELYPEDLLIDHQTSCNPSRALPSLNTGSSSSRGV-E-----DPDVIFQ TARSY42503_PE1 NOISO ADETMLPCEFEEFVAQE---TEHLTSCNPSRALTSLNTGSSFPRGV-E-----EPDVIFQ TUPGBGS_5528_PE3 NOISO ADETMLPCEFCEELYPEELLIDHQTSCNPSHALPSLHTGSSSPKGV-E-----DPDVILQ TURTRGS_415_PE5 NOISO ADETMLPCEFCEELYPEELLIDHQTSCNPSCALPPISVGNASPKGV-E-----DPDVIFQ MATCH * ** . . : . CONSENSUS ADETMLPCEFCEELYPEELLIDHQTSCNPS?ALPSL??GSSSPRGV?E?????DPDVIFQ

AILMEGL193246_1_PE3 NOISO KFLQQ---AA-SNQLDSLMGLNDSPPVED-GIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP BOVIN17_66_PE12 ENSBTAG00000008761 KLMRE---SA-GGQFESLMGFSSSAPVED-SVVIPCEFCGVQLEEEVLFHHQ-DQCDQRP BOVIN17_66_PE13 ISOFORMIN KLMRE---SA-GGQFESLMGFSSSAPVED-SVVIPCEFCGVQLEEEVLFHHQ-DQCDQRP CALJA9_108_PE25 NOISO NFLQQ---AA-SNQLDSLMGLSNSRPVEE-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP CANFA26_14_PE4 ENSCAFG00000008830 KFLQQ---AA-NNQLDSLMGLSSSPPVKD-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP CANFA26_14_PE5 ISOFORMIN KFLQQ---AA-NNQLDSLMGLSSSPPVKD-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP CAVPO115_4_PE9 NOISO SFLQR---AT-SNQWDSLMGLSDSPPVED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP CHICK15_PE212 ENSGALG00000004802 -----------YNSCRSDYSSRYQAVQEEGNIIIPCEFCGKGLEEEIVFHHQ-DQCDLRP CHOHOGS_3501_PE1 NOISO KVLQQ---TE-NNHLDSLIGLTNSPPMEDSSIIIPCEFCGVQLEEEVLFHHQ-DQCDQRS DASNOGS_3144_PE1 NOISO KFLQQ---AA-NNQLDSSMGLTNSPPMED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQCL DIPORGS_2952_PE1 NOISO NILQQ---AT-YDQLGFITGLNTLSPVEG-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP ECHTEGS_3767_PE1 NOISO KFLQQ---A---NELESLMGLTSSPPVEE-SIIIPCEFCGVQLEEEVLFHHQ-XXXDQRP FELCAGS_2104_PE1 NOISO KFLQQ---AA-SNQLDSLMGLSNSPPVED-SVIIPCEFCGVQLEEEVLFHHQ-DQCDQRP GORGO12_117_PE5 NOISO NFLQQ---AA-SNQLDSLMGLSNSHPVEE-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP HORSE8_21_PE5 NOISO KYLQQ---AA-SNQLDSLMGLSSSPPVED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP HS12_PE2264 ENSG00000135148 NFLQQ---AA-SNQLDSLMGLSNSHPVEE-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP HS12_PE2265 ISOFORMIN NFLQQ---AA-SNQLDSLMGLSNSHPVEE-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP LAMPAGS_432_PE5 NOISO KLMQQ---AA-SNQFDSLMGLSSSPPVED-SVIIPCEFCGVQLEEEVLFHHQ-DQCDQRP LOXAF84_7_PE20 NOISO KFLQQ---A---NQLESLMGLPNSPPVED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP MACEUGS_4452_PE1 NOISO RLLDLPATRAISSRFRSLLDLPAAPSGES-GIIIPCEFCGVQLEEEVLFHHQ-DQCDLRP MACMU11_117_PE5 NOISO NFLQQ---AA-SKQLDSLMGLSSSRLVEE-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP MICMUGS_1957_PE1 NOISO NFLQQ---AA-SNQLDSLMGMNNSPSVED-TVIIPCEFCGVQLEEEVLFHHQ-DQCDQRP MONDO3_509_PE7 ISOFORMIN RFLDLPASRAISSRFRSPLDLSAAPSGES-SIIIPCEFCGVQLEEDVLFHHQ-DQCDLRP MONDO3_509_PE8 ISOFORMIN RFLDLPASRAISSRFRSPLDLSAAPSGES-SIIIPCEFCGVQLEEDVLFHHQ-DQCDLRP MONDO3_509_PE9 ENSMODG00000002929 RFLDLPASRAISSRFRSPLDLSAAPSGES-SIIIPCEFCGVQLEEDVLFHHQ-DQCDLRP MOUSE5_PE2224 ENSMUSG00000042726 NFLQQ---AT-SNQFDTLMGLSSSAAVED-SIIIPCEFCGVQLEEEVLFYHQ-DQCDQRP MOUSE5_PE2225 ISOFORMIN NFLQQ---AT-SNQFDTLMGLSSSAAVED-SIIIPCEFCGVQLEEEVLFYHQ-DQCDQRP MYOLUGS_5807_PE3 NOISO RFLQQ---AT-SNQFNSLMGLSNAPSVEG-GIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP OCHPRGS_607_1_PE4 NOISO NFLQQ---AT-SSQLGTLMGLNSSHSVED-SVIIPCEFCGVQLEEEVLFHHQ-XXXXXXX ORNAN2_2_PE13 ENSOANG00000004805 SFLELPATRAPGSRYRSLLELPAGPSAEG-SIIIPCEFCGVQLEEEILFHHQKDQCDLRP ORNAN2_2_PE14 ISOFORMIN SFLELPATRAPGSRYRSLLELPAGPSAEG-SIIIPCEFCGVQLEEEILFHHQKDQCDLRP ORNAN2_2_PE15 ISOFORMIN SFLELPATRAPGSRYRSLLELPAGPSAEG-SIIIPCEFCGVQLEEEILFHHQKDQCDLRP PANTR12_118_PE6 NOISO NFLQQ---AA-SNQLDSLMGLSNSHPVEE-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP PIG14_41_PE16 NOISO EIMQQ---AA-RNQL-DSLGLRSSPPVED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP PONPY12_119_PE4 NOISO NFLQQ---AA-SNQLDSLMGLSNSHPVEE-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP PROCAGS_3263_PE1 NOISO KFLQQ---A---SQLESLMGLPSSPPVED-SIIIPCEFCGVQLEEEVLFHHQ-EQCDQRP PTEVAGS_3824_PE4 NOISO KFLQQ---AA-SNQLDSLMGLNTSPLVED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP RABIT21_9_PE5 NOISO NFLQQ---AT-SNQLGSLMVLNNSRPVEE-SVIIPCEFCGVQLEEEVLFHHQ-DQCDQRP RAT12_PE720 NOISO NFLQQ---AT-SNQLDTLMGLSSSAAVED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP SORAR140962_PE1 NOISO KLLQE---AA-SNQLDSLMGLKSPGPAED-SVIIPCEFCGVQLEEEVLFHHQ-DQCDQRP SPETRGS_2491_PE1 NOISO NFLQQ---AT-SNQLDSLMGLSNSPPVED-SVIIPCEFCGVQLEEEVLFHHQ-DQCDQRP TARSY42503_PE1 NOISO NFLQQ---AT-SNQLDSLMGLSSSPSVDD-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQHP TUPGBGS_5528_PE3 NOISO NFLQQ---AA-SNQFKSLMGLSNSAPVED-SIIIPCEFCGVQLEEEVLFHHQ-------- TURTRGS_415_PE5 NOISO MXXXX---XXXXXQLDSLMGLSSSPSVED-SIIIPCEFCGVQLEEEVLFHHQ-DQCDQRP MATCH . ::******* ***:::*:** CONSENSUS ?FLQQ???AA?SNQLDSLMGLS?SPPVED?SIIIPCEFCGVQLEEEVLFHHQ?DQCDQRP

AILMEGL193246_1_PE3 NOISO ATANNH-----VTEGIPRQDFQPPETSPELPKRRVRHQGDLSSGYMDDIKQETAKGPTYP BOVIN17_66_PE12 ENSBTAG00000008761 ATANNH-----VSEGIPSQDLQPRETSPELPKRRVRHQGDLSSGYMNDLKQEMAKGPTYP BOVIN17_66_PE13 ISOFORMIN ATANNH-----VSEGIPSQDLQPRETSPELPKRRVRHQGDLSSGYMNDLKQEMAKGPTYP CALJA9_108_PE25 NOISO TTATNH-----VTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDIKQETANGPTSC CANFA26_14_PE4 ENSCAFG00000008830 ATANNH-----VTEGIPRQDFQPPETSPDLPKRRVRHQGDLSSGYMDDIKQETAKGPTYP CANFA26_14_PE5 ISOFORMIN ATANNH-----VTEGIPRQDFQPPETSPDLPKRRVRHQGDLSSGYMDDIKQETAKGPTYP CAVPO115_4_PE9 NOISO ATASHH-----VLDGIPRQDSQPPETSAELPRRRVKHQGDLSSGYMDDTKQEAAKGPTYS CHICK15_PE212 ENSGALG00000004802 ATANPADNLPSQQPPSPR-DNRERRESPDLARRRIRHQGDVSPGCIEDLRQQRLNCPAR- CHOHOGS_3501_PE1 NOISO ATANNR-----VIEGFPSQDSQPRETSPELPRRRVRHQGDLSSGYLDGIKQETAKGPTYH DASNOGS_3144_PE1 NOISO TMANNH-----V-TGFPRQNAQPQDTSPVLPRRCVRHQGDMPSGYMDDIQLQTDKGPTYP DIPORGS_2952_PE1 NOISO ATAHSH-----GTEGFRRQDPQRQEASPEQLRRRSRHQGDLSSGYVEDTKQGTAKGSAYP ECHTEGS_3767_PE1 NOISO ATTTLV-----T---RSRQDSQ-PETSPELPRRRVRHQGDLPTSYMELIKQEEAKGPTYP FELCAGS_2104_PE1 NOISO ATANNH-----VTEGIPRQDFQHPETSPELPKRRVRHQGDLSSGYMDDIKQEMAKGPTYP GORGO12_117_PE5 NOISO A---NH-----VTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDIKQETANGPTSC HORSE8_21_PE5 NOISO ATANNH-----VTEGIPRQDFQPRETSPELPKRRVRHQGDLSSGYMDDIKQETANGPAYP HS12_PE2264 ENSG00000135148 ATATNH-----VTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSC HS12_PE2265 ISOFORMIN ATATNH-----VTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSC LAMPAGS_432_PE5 NOISO ATTNSH-----VSEGIPRPDFQPQETSPELPKRRVRHQGDLSSGYMDDLKQKTAKGPTYP LOXAF84_7_PE20 NOISO ATANHH-----VMEGFPRQDSRPRETSPELPRRRVRHQGDLSSGYMDDTKQETAKGPTYP MACEUGS_4452_PE1 NOISO GTATRR-----MAEPLPKQDSLQPVTSPELPRRRIRHQGDLSSCYMDDIRQETASKPMYP MACMU11_117_PE5 NOISO ATATNH-----VTEGIPRLDSQPQENSPELPRRRVRHQGDLSSGYLDDIKQETANGPTSC MICMUGS_1957_PE1 NOISO ATANNH-----GTEGIPRQDSQPRETSPELPRRRVKHQGDLSSGYMDDIKQETANGPTHP MONDO3_509_PE7 ISOFORMIN GTGVPVQWLLPAYESLPKQGSSQPETSPELPRRRVRHQGDLSSCYMDDIRQEAASKPAYP MONDO3_509_PE8 ISOFORMIN GTGVPVQWLLPAYESLPKQGSSQPETSPELPRRRVRHQGDLSSCYMDDIRQEAASKPAYP MONDO3_509_PE9 ENSMODG00000002929 GTGVPVQWLLPAYESLPKQGSSQPETSPELPRRRVRHQGDLSSCYMDDIRQEAASKPAYP MOUSE5_PE2224 ENSMUSG00000042726 ATANHR-----AVEGIPAQDSQPENTSAELSRRRVKHQGDLSSGYMDDVKPESVKGPTYS MOUSE5_PE2225 ISOFORMIN ATANHR-----AVEG