Alignment of the gene Family HOG000168445 of HOGENOM

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Isoforms are ON
AILMEGL193445_1_PE11 NOISO ------------------------------------------------------------ ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO --------MPPA---APA-----RLALALGLGLW-LGALAGV------------PGRGCG CALJA12_3_PE50 ENSCJAG00000015073 ------------------------------------------------------------ CANFA6_43_PE42 NOISO ------------------------------------------------------------ CAVPO4_23_PE41 NOISO --------MPEP---RPS-----VCRRALGRRGHERAALTMP-----------------P CHICK14_PE230 ENSGALG00000005714 ------------------------------------------------------------ CHICK14_PE231 ISOFORMIN ------------------------------------------------------------ DANRE1_57_PE22 NOISO ------------------------------------------------------------ DIPORGS_421_PE4 NOISO --------MPPG---APA-----RLALALGLGLW-LGALAGG------------SGLGCG ERIEUGS_1621_PE2 NOISO ------------------------------------------------------------ FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN DRLYPSENMASASRGLASAPFC-----LWRSGAWRRGAPGRRGTAAGAAARVPRTAAACW FUGRU189_PE63 ISOFORMIN ------------------------------------GDGGR-SC--------SPCPANCS FUGRU189_PE64 ENSTRUG00000008067 ------------------------------------GDGGR-SC--------SPCPANCS FUGRU189_PE65 ISOFORMIN ------------------------------------------------------------ GASACGROUPIX_16_PE21 ENSGACG00000018946 ----------------PSGFFCSLLAALCCLGAWGSGPQGDGARS-------------CY GORGO16_3_PE27 ENSGGOG00000007016 --------MPPA---APV-----RLALALGLGLW-LGALAGG------------PGRGCG HORSE13_41_PE34 ENSECAG00000006899 ------------------------------------------------------------ HORSE13_41_PE35 ISOFORMIN ------------------------------------------------------------ HS16_PE357 ENSG00000008710 --------MPPA---APA-----RLALALGLGLW-LGALAGG------------PGRGCG HS16_PE358 ISOFORMIN --------MPPA---APA-----RLALALGLGLW-LGALAGG------------PGRGCG HS16_PE359 ISOFORMIN --------MPPA---APA-----RLALALGLGLW-LGALAGG------------PGRGCG HS16_PE360 ISOFORMIN --------MPPA---APA-----RLALALGLGLW-LGALAGG------------PGRGCG LOXAF53_15_PE1 NOISO ------------------------------------------------------------ MACEUGS_650_PE4 NOISO ------------------------------------------------------------ MICMUGS_282_PE3 NOISO ------------------------------------------------------------ MONDO6_161_PE25 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE26 ENSMODG00000016034 ------------------------------------------------------------ MONDO6_161_PE27 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE28 ISOFORMIN ------------------------------------------------------------ MOUSE17_PE457 NOISO --------MPLG---APA-----LLALALGLGLW-LGALAGD------------PGRGCG MYOLUGS_6259_PE4 NOISO ------------------------------------------------------------ OCHPRGS_50_PE1 NOISO ------------------------------------------------------------ ORYLA1073_PE1 NOISO ------------------------------------------------------------ PIG3_37_PE90 NOISO -----------------R-----PPGLALGLGLW-LGALAGV------------PGRGCG POEGU14_10_PE12 NOISO ------------------------------------------------------------ PONPY16_3_PE15 ENSPPYG00000006987 --------MPPA---APA-----RLALALGLGLW-LGALAGG------------PGRGCG PONPY16_3_PE16 ISOFORMIN --------MPPA---APA-----RLALALGLGLW-LGALAGG------------PGRGCG PROCAGS_6650_PE5 NOISO -----------M---PPA-----RLVLALGLGLC-LVALAAD------------SGCGCW PTEVAGS_3466_PE5 NOISO -----------M---PPA-----RLALALGLGLW-LGALAGI------------PGRGCG RAT10_PE262 NOISO --------MPPG---APA-----RLALALGLGLW-LGALAGD------------PGRGCG TETNG18_PE189 ENSTNIG00000014075 DRLYPSENMASASRGSASAPFC-----LRRSGAWRPGAPGHRGTAPGAAARVPPTAAACR TETNG18_PE190 ISOFORMIN ------------------------------------------------------------ TURTRGS_3086_PE5 NOISO --------------------------------VW-FGAFSDV------------PGRGCG XENTR27_4_PE10 ISOFORMIN --------KDGA---SPP-----KLGLRLCPLFLLLLGLGSG------------AAAWCQ XENTR27_4_PE11 ISOFORMIN -------------------------------LFLLLLGLGSG------------AAAWCQ XENTR27_4_PE12 ISOFORMIN ------------------------------------------------------------ XENTR27_4_PE8 ENSXETG00000015945 --------KDGA---SPP-----KLGLRLCPLFLLLLGLGSG------------AAAWCQ XENTR27_4_PE9 ISOFORMIN --------KDGA---SPP-----KLGLRLCPLFLLLLGLGSG------------AAAWCQ MATCH CONSENSUS ????????????????????????????????????????????????????????????

AILMEGL193445_1_PE11 NOISO ------------------------------------------------------------ ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO P----------CAPPCLCGPA-P-GAACLVNCSGQGLRTLGPALRIPADATAL------- CALJA12_3_PE50 ENSCJAG00000015073 ------------------------------------------------------------ CANFA6_43_PE42 NOISO ------------------------------------------------------------ CAVPO4_23_PE41 NOISO G----------APARCLCGPA-P-GASCRVNCSGRGLRKLGPELRIPADTTVL------- CHICK14_PE230 ENSGALG00000005714 ----------------------------------QGLEFIGNKQRL-------------- CHICK14_PE231 ISOFORMIN ------------------------------------------------------------ DANRE1_57_PE22 NOISO ------------------------------------------------------------ DIPORGS_421_PE4 NOISO P----------CEGPCLCDPG-P-GAACRVNCSGRGLRTLGPALRIPAAATAL------- ERIEUGS_1621_PE2 NOISO ------------------------------------------------------------ FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN RRRPNTPASSTAPTSAWRGPQQPPTSRWLLLCCKISLEIFPRITSPPLISAFW------- FUGRU189_PE63 ISOFORMIN CV-----------------LATAPQHSCVVNCTNIGLERAPAAADIPLATSVL------- FUGRU189_PE64 ENSTRUG00000008067 CV-----------------LATAPQHSCVVNCTNIGLERAPAAADIPLATSVL------- FUGRU189_PE65 ISOFORMIN ----------------------------------------------------R------- GASACGROUPIX_16_PE21 ENSGACG00000018946 P----------CPVNCSCAPVGPQ-PSCVVNCSNVGLERAPAAAEVPQATNVL------- GORGO16_3_PE27 ENSGGOG00000007016 P----------CEPPCLCGPA-P-GAACRVNCSGRGLRTLGPALRIPADATAL------- HORSE13_41_PE34 ENSECAG00000006899 ------------------------------------------------------------ HORSE13_41_PE35 ISOFORMIN ------------------------------------------------------------ HS16_PE357 ENSG00000008710 P----------CEPPCLCGPA-P-GAACRVNCSGRGLRTLGPALRIPADATAL------- HS16_PE358 ISOFORMIN P----------CEPPCLCGPA-P-GAACRVNCSGRGLRTLGPALRIPADATAL------- HS16_PE359 ISOFORMIN P----------CEPPCLCGPA-P-GAACRVNCSGRGLRTLGPALRIPADATALTAMAKAD HS16_PE360 ISOFORMIN P----------CEPPCLCGPA-P-GAACRVNCSGRGLRTLGPALRIPADATAL------- LOXAF53_15_PE1 NOISO -------------------PG-P-VAACRVNCSGRGLQTLGPALRIPTEATAL------- MACEUGS_650_PE4 NOISO ------------------------------------------------------------ MICMUGS_282_PE3 NOISO ------------------------------------------------------------ MONDO6_161_PE25 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE26 ENSMODG00000016034 ------------------------------------------------------------ MONDO6_161_PE27 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE28 ISOFORMIN ------------------------------------------------------------ MOUSE17_PE457 NOISO P----------CPLPCFCGPA-P-DAACRVNCSGRWLQTLGPSLRIPADATAL------- MYOLUGS_6259_PE4 NOISO ------------------------------------------------------------ OCHPRGS_50_PE1 NOISO ------------------------------------------------------------ ORYLA1073_PE1 NOISO -------------------------------CLFVSAEICQKTTSPPLIVACW------- PIG3_37_PE90 NOISO P----------CAPPCLCGPA-P-GAACRVNCSGLGLRILGPALRIPADATAL------- POEGU14_10_PE12 NOISO ------------------------------------------------------------ PONPY16_3_PE15 ENSPPYG00000006987 P----------CEPPCLCSPA-P-GAACHVNCSGRGLRTLGPALRIPADATAL------- PONPY16_3_PE16 ISOFORMIN P----------CEPPCLCSPA-P-GAACHVNCSGRGLRTLGPALRIPADATALTVMAKAD PROCAGS_6650_PE5 NOISO S----------CAPTCICGPX-X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX------- PTEVAGS_3466_PE5 NOISO P----------CAPPCLCGPA-P-GAACRVNCSGRGLRTLGPALRIPADATAL------- RAT10_PE262 NOISO P----------CPLPCFCSPA-P-DAACRVNCSGRWLQTLGPSLRIPADATAL------- TETNG18_PE189 ENSTNIG00000014075 RRGPDSRASSTAPASAWRGPRGPRTSRWPLLCCKTTSEIFPGTTSPPLTPAFW------- TETNG18_PE190 ISOFORMIN -------------------------------------DLSRN-HISSFDTS-L------- TURTRGS_3086_PE5 NOISO P----------CAPTCLCGPA-P-GAACRVNCSGRGLRTLGPALRIPADATAL------- XENTR27_4_PE10 ISOFORMIN P----------CPENCTCANG-SEPASCLVNCSGRGLLGAEAA---PLEVTALDLSYNSI XENTR27_4_PE11 ISOFORMIN P----------CPENCTCANG-SEPASCLVNCSGRGLLGAEAA---PLEVTALDLSYNSI XENTR27_4_PE12 ISOFORMIN ------------------------------------------------------------ XENTR27_4_PE8 ENSXETG00000015945 P----------CPENCTCANG-SEPASCLVNCSGRGLLGAEAA---PLEVTALLTATDQS XENTR27_4_PE9 ISOFORMIN P----------CPENCTCANG-SEPASCLVNCSGRGLLGAEAA---PLEVTALTHLNPLH MATCH CONSENSUS ????????????????????????????????????????????????????????????

AILMEGL193445_1_PE11 NOISO -----------------------DVSHNLLQALDVGLLANLS-ALTELDISNNRISTLEE ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO -----------------------DVSHNLLQALDIGLLANLS-ALMELDISNNKISTLEE CALJA12_3_PE50 ENSCJAG00000015073 -----------------------DVSHNLLQALDVGLLANLS-ALAELDISNNKISTLEE CANFA6_43_PE42 NOISO -----------------------DVSHNLLRALDVGLLANLS-ALTELDISNNKISTLEE CAVPO4_23_PE41 NOISO -----------------------DVSHNLLQTLDVGLLANLS-ALVELDISNNRISTLEE CHICK14_PE230 ENSGALG00000005714 ---------------ISEISILRDLSRNKISALDVQMFRSLT-SLAKLDISHNKISTLEE CHICK14_PE231 ISOFORMIN -----------------------DLSRNKISALDVQMFRSLT-SLAKLDISHNKISTLEE DANRE1_57_PE22 NOISO -----------------------DLSRNRIHSVDWSLFDHLT-ALKELDLSNNQITTIEE DIPORGS_421_PE4 NOISO -----------------------DLSHNLLHTLDAGLLANLS-ALVELDISDNKISTLEE ERIEUGS_1621_PE2 NOISO ------------------------------------------------------------ FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN -----------------------SES--------------WD-FVSCDDLSNNQISTIEE FUGRU189_PE63 ISOFORMIN -----------------------DLSKNHISSFDISLLERVV-GLRELDLSNNQISTIEE FUGRU189_PE64 ENSTRUG00000008067 -----------------------DLSKNHISSFDISLLERVV-GLRELDLSNNQISTIEE FUGRU189_PE65 ISOFORMIN -----------------------DLSKNHISSFDISLLERVV-GLRELDLSNNQISTIEE GASACGROUPIX_16_PE21 ENSGACG00000018946 -----------------------DLSKNHISSLDTGLLDRLT-VLRELDLSNNLITTIDE GORGO16_3_PE27 ENSGGOG00000007016 -----------------------DVSHNLLRALDVGLLANLS-ALAELDISNNKISTLEE HORSE13_41_PE34 ENSECAG00000006899 -----------------------DVSHNLLQALDVGLLANLS-VLTELDISNNKISTLEE HORSE13_41_PE35 ISOFORMIN -----------------------DVSHNLLQALDVGLLANLS-VLTELDISNNKISTLEE HS16_PE357 ENSG00000008710 -----------------------DVSHNLLRALDVGLLANLS-ALAELDISNNKISTLEE HS16_PE358 ISOFORMIN -----------------------DVSHNLLRALDVGLLANLS-ALAELDISNNKISTLEE HS16_PE359 ISOFORMIN GDVKKYGSKRGALALTHGHSLLRDVSHNLLRALDVGLLANLS-ALAELDISNNKISTLEE HS16_PE360 ISOFORMIN -----------------------DVSHNLLRALDVGLLANLS-ALAELDISNNKISTLEE LOXAF53_15_PE1 NOISO -----------------------DVSHNLLRALDTGLLANLS-ALTELDISNNKISTLEE MACEUGS_650_PE4 NOISO -----------------------DISDNFISTLETEFFENLS-ALVQLDISNNKISTLEE MICMUGS_282_PE3 NOISO -----------------------DVSHNLLQSLDVGLLANLS-ALTELDISNNEISTLEE MONDO6_161_PE25 ISOFORMIN ----------------------RDLSDNFINTLETEFFENLS-ALTQLDISNNKILTLEE MONDO6_161_PE26 ENSMODG00000016034 -----------------------DLSDNFINTLETEFFENLS-ALTQLDISNNKILTLEE MONDO6_161_PE27 ISOFORMIN -----------------------DLSDNFINTLETEFFENLS-ALTQLDISNNKILTLEE MONDO6_161_PE28 ISOFORMIN -----------------------DLSDNFINTLETEFFENLS-ALTQLDISNNKILTLEE MOUSE17_PE457 NOISO -----------------------DLSHNLLQTLDIGLLVNLS-ALVELDLSNNRISTLEE MYOLUGS_6259_PE4 NOISO -----------------------DVSHNLLRALDVGLLANLS-ALTELDISNNKISTLEE OCHPRGS_50_PE1 NOISO -----------------------------------------------------KISALEE ORYLA1073_PE1 NOISO -----------------------TAC--------------RA-FESCKDLSNNQITTIEE PIG3_37_PE90 NOISO -----------------------DVSHNLLRALDVGLLENLS-ALTELDISNNRISALEE POEGU14_10_PE12 NOISO ---------------------------------------------------------LED PONPY16_3_PE15 ENSPPYG00000006987 -----------------------DVSHNLLRALDVGLLANLS-ALAELDISNNKISTLEE PONPY16_3_PE16 ISOFORMIN GDVEKYGSKRGALALTHGHSLLRDVSHNLLRALDVGLLANLS-ALAELDISNNKISTLEE PROCAGS_6650_PE5 NOISO -----------------------DVSHNLLRALDMGLLGNLS-ALTELDISHNKISTLEE PTEVAGS_3466_PE5 NOISO -----------------------DVSHNLLRALDVGLLANLS-ALTELDISNNRXXXXXX RAT10_PE262 NOISO -----------------------DLSHNLLQTLDIRLLVNLS-GLVELDLSNNRISTLEE TETNG18_PE189 ENSTNIG00000014075 -----------------------SGS--------------LA-FVSCDDLSNNQISTIEE TETNG18_PE190 ISOFORMIN -----------------------LER--------------IS-GLRELDLSNNQISTIEE TURTRGS_3086_PE5 NOISO -----------------------DVSHNLLRALDIGLLANLS-ALTELDISNNKISTLEE XENTR27_4_PE10 ISOFORMIN ------K------------------SL-------DKELFENLHFLRELNISNNQISTLEE XENTR27_4_PE11 ISOFORMIN ------K------------------SL-------DKELFENLHFLRELNISNNQISTLEE XENTR27_4_PE12 ISOFORMIN --------S------------LGMSVL-------RLLTQELIALLCCRNISNNQISTLEE XENTR27_4_PE8 ENSXETG00000015945 ------ELI------------LGVVNL-------H-LGANYRKWVTELNISNNQISTLEE XENTR27_4_PE9 ISOFORMIN GSWKSVPLASAFVNKPHGHPTIGDLSVRFSEVAQSALLQAVAGRKEFWNISNNQISTLEE MATCH CONSENSUS ?????????????????????????S??????????????????L??LD?SNN?I?T?EE

AILMEGL193445_1_PE11 NOISO GIFANLFNLSEINLSGNPWACDCALAWLPR----W-AEERQVLMVRPEAATCAGPGPLAG ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO GIFANLFNLSEVNLGGNPLECDCGLAWLPR----W-VEGQRVRVVRPEAATCAGPGPLAG CALJA12_3_PE50 ENSCJAG00000015073 GLFANLFNLSEMSCGSF-----GGCHWVGPQVPSIPSASQLVRVSSPGRLCCHRCSKAWG CANFA6_43_PE42 NOISO GIFSNLFNLSEINLSGNPLECDCGLAWLPR----W-AEEQQVHVVRPEAATCAGPGPLAG CAVPO4_23_PE41 NOISO GIFANLFNLSEINLSRNPFECDCGLVWLRH----W-AEEKQVLVVQPEEATCTGPGPLAG CHICK14_PE230 ENSGALG00000005714 GIFDNLFNLSEINLSWNPFFCDCKLSWLPR----W-VEDRKVTVLQAADTRCAHPPGVAN CHICK14_PE231 ISOFORMIN GIFDNLFNLSEINLSWNPFFCDCKLSWLPR----W-VEDRKVTVLQAADTRCAHPPGVAN DANRE1_57_PE22 NOISO RTCDHLFNLTTIDLSFNPFLCDCKLVRLVS----W-LQEQGVKVKRPNSMLCDRPPEVRN DIPORGS_421_PE4 NOISO GVFANLFNLSEINLSGNPFECDCGLLWLPR----W-VEERRVRMAPARVATCAGPGPLAG ERIEUGS_1621_PE2 NOISO ------------------------------------------------------------ FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN GTCNRQCNLTQIDLSGNPFECHCKLFRLVS----W-LREKGVKVRRPEATLCDNPPALRH FUGRU189_PE63 ISOFORMIN GTCNRQCNLTQIDLSGNPFECHCKLFRLVS----W-LREKGVKVRRPEATLCDNPPALRH FUGRU189_PE64 ENSTRUG00000008067 GTCNRQCNLTQIDLSGNPFECHCKLFRLVS----W-LREKGVKVRRPEATLCDNPPALRH FUGRU189_PE65 ISOFORMIN GTCNRQCNLTQIDLSGNPFECHCKLFRLVS----W-LREKGVKVRRPEATLCDNPPALRH GASACGROUPIX_16_PE21 ENSGACG00000018946 RIYDNLCNLTQIDLSGNPFDCDCKLFRLVS----W-LQEKGVRVRRPEDMLCRQPPELLG GORGO16_3_PE27 ENSGGOG00000007016 GIFANLFNLSEINLSGNPFECDCGLAWLPR----W-AEEQQVRVVQPEAATCAGPGSLAG HORSE13_41_PE34 ENSECAG00000006899 GIFANLFNLSEINLSGNPLECDCGLAWLPR----W-AEEQRVRVVRPEAATCAGPGPLAG HORSE13_41_PE35 ISOFORMIN GIFANLFNLSEINLSGNPLECDCGLAWLPR----W-AEEQRVRVVRPEAATCAGPGPLAG HS16_PE357 ENSG00000008710 GIFANLFNLSEINLSGNPFECDCGLAWLPR----W-AEEQQVRVVQPEAATCAGPGSLAG HS16_PE358 ISOFORMIN GIFANLFNLSEINLSGNPFECDCGLAWLPR----W-AEEQQVRVVQPEAATCAGPGSLAG HS16_PE359 ISOFORMIN GIFANLFNLSEINLSGNPFECDCGLAWLPR----W-AEEQQVRVVQPEAATCAGPGSLAG HS16_PE360 ISOFORMIN GIFANLFNLSEINLSGNPFECDCGLAWLPR----W-AEEQQVRVVQPEAATCAGPGSLAG LOXAF53_15_PE1 NOISO GTFANLLNLSDVDLSGNPLECDCGLAWLPR----W-AEAQGVRLGQLEGPMCAGPGPLTG MACEUGS_650_PE4 NOISO GIFANLFNLSEINLSVNPFVCDCNLSWFPI----W-VDEQKVSVVQLREARCAEPPHLAD MICMUGS_282_PE3 NOISO GIFDNLFNLSEINLSGNPFECDCGLAWLPR----W-VEEQRVRVVQPEAATCAGPGPLAG MONDO6_161_PE25 ISOFORMIN GIFANLFNLSEINLSLNPFICDCNLSWFPS----W-VDEQKVSVVQPRETRCAEPPRLAD MONDO6_161_PE26 ENSMODG00000016034 GIFANLFNLSEINLSLNPFICDCNLSWFPS----W-VDEQKVSVVQPRETRCAEPPRLAD MONDO6_161_PE27 ISOFORMIN GIFANLFNLSEINLSLNPFICDCNLSWFPS----W-VDEQKVSVVQPRETRCAEPPRLAD MONDO6_161_PE28 ISOFORMIN GIFANLFNLSEINLSLNPFICDCNLSWFPS----W-VDEQKVSVVQPRETRCAEPPRLAD MOUSE17_PE457 NOISO GVFANLFNLSEINLSGNPFECNCGLAWLPR----W-AKEHQVHVVQSEATTCRGPIPLAG MYOLUGS_6259_PE4 NOISO GTFANLFNLSEXXXXXXXXXCDCL--ALPR----W-VEQR--VHVQPEAATCAGPGPLAG OCHPRGS_50_PE1 NOISO GTFNL--FLSEINLSGNPFECGCGLAWLPR----W-LEEQQVRVVQPEAATCAGPAPLAG ORYLA1073_PE1 NOISO RICDNLCNLTEIDLSGNPFECNCKLFRLLR----W-LQVKGVQVRHPNSMLCHQPPELHS PIG3_37_PE90 NOISO GIFANLFNLSEINLSGNPLECDCGLAWLPR----W-AEERRVRLLRPEAATCAGPGPLAG POEGU14_10_PE12 NOISO GIFDNLFNLSEINLSWNPFVCDCKLSWLPR----W-VEERKVRVLEASDTRCAHPPEVAN PONPY16_3_PE15 ENSPPYG00000006987 GIFANLFNLSEINLSGNPFECDCGLAWLPR----W-AEEQQVRVVQPEAATCAGPGSLAG PONPY16_3_PE16 ISOFORMIN GIFANLFNLSEINLSGNPFECDCGLAWLPR----W-AEEQQVRVVQPEAATCAGPGSLAG PROCAGS_6650_PE5 NOISO GAFAHSCNLSDIDLSGNPLECDCGLAWLPR----W-AEAQGVRLGQPGGPTCAGPGPLAG PTEVAGS_3466_PE5 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----X-XXXXXXXXXXXXXXXXXXXXXXXX RAT10_PE262 NOISO GVFANLFNLSEINLSGNPFECNCGLAWLPR----W-AKEQQVHVVQSEATTCRGPVPLAG TETNG18_PE189 ENSTNIG00000014075 GTCNRQCNLSQIDLSGNPFQCHCKLHRLVG----W-LRDKGVRLRRPEAMLCDNPPELRH TETNG18_PE190 ISOFORMIN GTCNRQCNLSQIDLSGNPFQCHCKLHRLVG----W-LRDKGVRLRRPEAMLCDNPPELRH TURTRGS_3086_PE5 NOISO GIFANLFNLSEINLSGNPLECDCGLAWLPR----W-AEEQQVRVVRPEAATCAGPGPLAG XENTR27_4_PE10 ISOFORMIN GIFSSLLNLSVIDLSDNPWLCDCHLYWLPC----W-VRDVGVSVQQENSTLCDQPSALAA XENTR27_4_PE11 ISOFORMIN GIFSSLLNLSVIDLSDNPWLCDCHLYWLPC----W-VRDVGVSVQQENSTLCDQPSALAA XENTR27_4_PE12 ISOFORMIN GIFSSLLNLSVIDLSDNPWLCDCHLYWLPC----W-VRDVGVSVQQENSTLCDQPSALAA XENTR27_4_PE8 ENSXETG00000015945 GIFSSLLNLSVIDLSDNPWLCDCHLYWLPC----W-VRDVGVSVQQENSTLCDQPSALAA XENTR27_4_PE9 ISOFORMIN GIFSSLLNLSVIDLSDNPWLCDCHLYWLPC----W-VRDVGVSVQQENSTLCDQPSALAA MATCH CONSENSUS G??????NL??I?LS?NP??C?C?L??L??????W??????V?????????C??P??L??

AILMEGL193445_1_PE11 NOISO QPLLGVPLLDGGCGEEYIACLPDNSSG-------AAA-LAAFSAVHTGPLTPEACSAFCF ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO QPLLGGALLDGACGEEYVACVPDDSSG-------AVA-LVAFLAAPEGPLAPEACSALCF CALJA12_3_PE50 ENSCJAG00000015073 WPLLSIVLWDSGCGEEYVACLPDNSSG-------TME-AVAFSPAHEGLLEPEACSAFCF CANFA6_43_PE42 NOISO QPLLGVPLLDGGCGEEYIACLPDNSSG-------AVA-LVAFSAAHEGPLTPEACGAFCF CAVPO4_23_PE41 NOISO QPLLGLSLVDTGCGEEYVACLPDNSSD-------TMV-LVAFSIAHEGPLAPEACSTFCF CHICK14_PE230 ENSGALG00000005714 LSLFSVSFVNATCGAQYVTCLTSNHTD-------EAELVILFTSSHPGNLTEETCSALCY CHICK14_PE231 ISOFORMIN LSLFSVSFVNATCGAQYVTCLTSNHTD-------EAELVILFTSSHPGNLTEETCSALCY DANRE1_57_PE22 NOISO QPLLNVSVHTCVCEETYAGCLQDEAHT-------AGVELVIFSSSTPGPFSREECNSKCF DIPORGS_421_PE4 NOISO QPL-DVTLLSGGCGEEYIACLPDNSSG-------TPT-VVALSSAHEGPLEPEACGALCF ERIEUGS_1621_PE2 NOISO ------------------------------------------------------------ FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN RPLLNVSLLTC--DLNYVACLKESSSG----GGAERSELVIFSSSTPGNFTREQCNSVCF FUGRU189_PE63 ISOFORMIN RPLLNVSLLTC--DLNYVACLKESSSG----GGAERSELVIFSSSTPGNFTREQCNSVCF FUGRU189_PE64 ENSTRUG00000008067 RPLLNVSLLTC--DLNYVACLKESSSG----GGAERSELVIFSSSTPGNFTREQCNSVCF FUGRU189_PE65 ISOFORMIN RPLLNVSLLTC--GRGRTFLHRPL------------------------------------ GASACGROUPIX_16_PE21 ENSGACG00000018946 QPLLNVSLLTC--GLNYAACLEDSSSGGG-----GRSELVIFSSSTPGNFTSEQCNSVCF GORGO16_3_PE27 ENSGGOG00000007016 QPLLGIPLLDSGCGEEYVACLPDNSSG-------TVA-AVSFSAAHEGLLQPEACSAFCF HORSE13_41_PE34 ENSECAG00000006899 RPLLGVPLLDGGCGEKYIACLPDNSTG-------AVA-LAAFSAAHEGLLAPEACSAFCF HORSE13_41_PE35 ISOFORMIN RPLLGVPLLDGGCGEKYIACLPDNSTG-------AVA-LAAFSAAHEGLLAPEACSAFCF HS16_PE357 ENSG00000008710 QPLLGIPLLDSGCGEEYVACLPDNSSG-------TVA-AVSFSAAHEGLLQPEACSAFCF HS16_PE358 ISOFORMIN QPLLGIPLLDSGCGEEYVACLPDNSSG-------TVA-AVSFSAAHEGLLQPEACSAFCF HS16_PE359 ISOFORMIN QPLLGIPLLDSGCGA--------------------------------------------- HS16_PE360 ISOFORMIN QPLLGIPLLDSGCGEEYVACLPDNSSG-------TVA-AVSFSAAHEGLLQPEACSAFCF LOXAF53_15_PE1 NOISO RPLLSVPFLDSSCGEEYVACLPDNSSG-------TVA-LVVFSVAHEGPLAPEACGAFCF MACEUGS_650_PE4 NOISO VPILSISFSDDTCDEESIACLQDNSSS-------TVT-LVTFSAMHDGVLAQNFCSAFCF MICMUGS_282_PE3 NOISO QPLLGIPLLDGSCGEEYVACLPDNSSG-------TVV-TATFSVAHEGLLDPEACGAFCF MONDO6_161_PE25 ISOFORMIN VPILSVSFSDGTCE---------------------------------------------- MONDO6_161_PE26 ENSMODG00000016034 VPILSVSFSDGTCDLEYIACVQDNSSS-------AMT-VVIFSAALDGEFTRNTCSAFCF MONDO6_161_PE27 ISOFORMIN VPILSVSFSDGTCDLEYIACVQDNSSS-------AMT-VVIFSAALDGEFTRNTCSAFCF MONDO6_161_PE28 ISOFORMIN VPILSVSFSDGTCDLEYIACVQDNSSS-------AMT-VVIFSAALDGEFTRNTCSAFCF MOUSE17_PE457 NOISO QPLLSIPLLDNACGEEYVACLPDNSSG-------AVA-AVPFYFAHEGPLETEACSAFCF MYOLUGS_6259_PE4 NOISO LPLLRVPLSDSGCGEKYVACLPNNSSG-------ATV-LVAFSVAHEGPLVPEACSAFCF OCHPRGS_50_PE1 NOISO QPLLSIPLLDSGCGEKYVACLPDNSSG-------IVA-TAAFT-ALGGQLGPETCSAFCF ORYLA1073_PE1 NOISO KPLLNVSRITC--GPSYAACLEDSSNGG------GRSELVIFTSLNAGNFTRQQCNSVCF PIG3_37_PE90 NOISO QPLLSVPLLDGSCGEEYIACVPDDSSG-------AVA-LAAFSAAHEGPPAPEACSAFCF POEGU14_10_PE12 NOISO LSLFDVLFLNATCGAQYITCLTGNYTE-------EAELIILFTSVHPGNLSEETCSALCY PONPY16_3_PE15 ENSPPYG00000006987 QPLLGIPLLDSGCGEEYVACLPDNSSG-------TMA-AVSFSAAHEGLLQPEACSAFCF PONPY16_3_PE16 ISOFORMIN QPLLGIPLLDSGCGA--------------------------------------------- PROCAGS_6650_PE5 NOISO RPLLSVPFLDSGCXXXXXXXXXXXXXX-------XXX-XXXXXXXXXXXXXXXXXXXXXX PTEVAGS_3466_PE5 NOISO XXXXXXXXXXXXXXEDYVACLPNNSLG-------AVA-LVTFSAAHEGPLLPEACSAFCF RAT10_PE262 NOISO RPLLSTPLLDNACGEEYVACLPDNSSG-------AVA-AVPFFFAHQGPLETAACSAFCF TETNG18_PE189 ENSTNIG00000014075 QPLLNASLLTS--GLNYVACLEDSSSGGGGGGGAGRSELVIFSLSKPGNFTREQCNSVCF TETNG18_PE190 ISOFORMIN QPLLNASLLTS--GLNYVACLEDSS----------RSELVIFSLSKPGNFTREQCNSVCF TURTRGS_3086_PE5 NOISO RPLLSGPLLDSSCGEEYVACVPDDSSG-------AVA-LVAFSAAHEGPLAPEACSAFCF XENTR27_4_PE10 ISOFORMIN QPLLNLSFP-GSCAADFIACPDNSSIH-------NESVLIFTPYNSASVNNVSDEFCSAL XENTR27_4_PE11 ISOFORMIN QPLLNLSFP-GSCAADFIACPDNSSIH-------NESVLIFTPYNSASVNNVSDEFCSAL XENTR27_4_PE12 ISOFORMIN QPLLNLSFP-GSCAADFIACPDNSSIH-------NESVLIFTPYNSASVNNVSDEFCSAL XENTR27_4_PE8 ENSXETG00000015945 QPLLNLSFP-GSCAADFIACPDNSSIH-------NESVLIFTPYNSASVNNVSDEFCSAL XENTR27_4_PE9 ISOFORMIN QPLLNLSFP-GSCGNTLLGPH--------------------------------------- MATCH CONSENSUS ?PLL???????????????C????????????????????????????????????????

AILMEGL193445_1_PE11 NOISO AAGQGLGALSDQGWCLCGAAWSPNAS--SACLPFCSSTLLPLAPACRG-PTLLQNIFPAS ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO EAGQALAALSEQGRCLCGAARPPNAS--SACLPSCSGPSLPLAPACRG-PSLLQHVFPAS CALJA12_3_PE50 ENSCJAG00000015073 STGQHLAALSEQGQCLCGAASPN-AS--SACLALCSSPLPPPAPACGG-PTLLQHVFPAS CANFA6_43_PE42 NOISO AAGNGLGAFSDQGWCLCGAAQPPNTS--SACLPFCSGAPLALAPACGG-PTLLQNIFPAS CAVPO4_23_PE41 NOISO LGGQGLAALSEQGQCLCGTAQTPNIS--VACLSLCSNP-LPPTPACGG-PTFLQHVFPSS CHICK14_PE230 ENSGALG00000005714 ADDQEYGGFSPQGQCLCGTAHEPNSS--SSCLLFCTEHS--SGQACGG-PSLIHFPFQAQ CHICK14_PE231 ISOFORMIN ADDQEYGGFSPQGQCLCGTAHEPNSS--SSCLLFCTEHS--SGQACGG-PSLIHFPFQAQ DANRE1_57_PE22 NOISO HENQRYGGLGQQRECLCSTNSEPNHISESQCSAACSDPLVMKEC--RWTVARDVFQVPKH DIPORGS_421_PE4 NOISO SASKGLAALAEQGRCVCGALQLPNTS--AACQSLCSSLLQPRSPTCSG-PTLLRNVFPAS ERIEUGS_1621_PE2 NOISO --GRGLAACSDQGLCLCGPVQPPNAS--EACLAFCSTPPL-LTPACGG-PTLLRHTFPTS FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN TASHRYGGLGGRHECLCSTNSEPNFISESQCSAACTNPQVMEVIG--------------- FUGRU189_PE63 ISOFORMIN TASHRYGGLGGRHECLCSTNSEPNFISESQCSAACTNPQVMEKIRIGLFLMT-------- FUGRU189_PE64 ENSTRUG00000008067 TASHRYGGLGGRHECLCSTNSEPNFISESQCSAACTNPQVMELRSFPFSCLLCL------ FUGRU189_PE65 ISOFORMIN ------------------------------------------------------------ GASACGROUPIX_16_PE21 ENSGACG00000018946 AALHRYGGLGARRECLCSTNSEPNFISKARCSAACTNPHVMKVRSTRWSPGVAFRRF--- GORGO16_3_PE27 ENSGGOG00000007016 STGQGLAALSEQGWCLCGAAQPSSAS--FACLS-CSSPPPPPAPTCRG-RTLLQHVFPAS HORSE13_41_PE34 ENSECAG00000006899 AAGQGLAALSEQGWCLCGAAQDPNVS--SACLPFCSDPLLPPAPACRG-PTLLQNVFPAS HORSE13_41_PE35 ISOFORMIN AAGQGLAALSEQGWCLCGAAQDPNVS--SACLPFCSDPLLPPAPACRG-PTLLQNVFPAS HS16_PE357 ENSG00000008710 STGQGLAALSEQGWCLCGAAQPSSAS--FACLSLCSGPPPPPAPTCRG-PTLLQHVFPAS HS16_PE358 ISOFORMIN STGQGLAALSEQGWCLCGAAQPSSAS--FACLSLCSGPPPPPAPTCRG-PTLLQHVFPAS HS16_PE359 ISOFORMIN ------------------------------------------------------------ HS16_PE360 ISOFORMIN STGQGLAALSEQGWCLCGAAQPSSAS--FACLSLCSGPPPPPAPTCRG-PTLLQHVFPAS LOXAF53_15_PE1 NOISO TAGQALAGLSEQGLCLCGAAQPSNAS--AACLPLCSGALLPL--TCGG-PTVLPHVFPAT MACEUGS_650_PE4 NOISO SLGQEYGGLSEEGHCFCGKAHSPNAS--SSCLLFCPGFTASP-AACRV-PVILHNVFPAS MICMUGS_282_PE3 NOISO SAGQGLAALSEQGQCLCGAAQPPNTS--SACLSLCSSPLPPAAPVCGG-PTLLQHVFYAS MONDO6_161_PE25 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE26 ENSMODG00000016034 SFGQQYGGLSEEGRCFCGTARSPNAS--SGCLRFCPGLAAPP-VACRV-PFILHNVFPAS MONDO6_161_PE27 ISOFORMIN SFGQQYGGLSEEGRCFCGTARSPNAS--SGCLRFCPGLAAPP-VACRV-PFILHNVFPAS MONDO6_161_PE28 ISOFORMIN SFGQQYGGLSEEGRCFCGTARSPNAS--SGCLRFCPGLAAPP-VACRV-PFILHNVFPAS MOUSE17_PE457 NOISO SAGEGLAALSEQNQCLCGAGQASNSS--AACSSWCSSISLSLNSACGG-PTLLQHTFPAS MYOLUGS_6259_PE4 NOISO STGQDFAALSEQGHCLCGTAHPPNTS--SICLSFCSRSPQPPAPACGG-PTILQNVFPAS OCHPRGS_50_PE1 NOISO STGWELAALSEQGECLCGAPQPLNTS--LACLSLCSSPPPSPSPACGG-PSLLQHVFPAS ORYLA1073_PE1 NOISO ALYHRYGGLGEHSECLCSTNIEPNLISESECSPDCTDPRVMTVT---------------- PIG3_37_PE90 NOISO AAGQDLAALSEQHGCLCGAARPPGAS--SACLRFCSGTRPPPSAACRG-PTLLHNVFPAS POEGU14_10_PE12 NOISO SQEQEYGGFSPQGQCVCGAAHETNSS--SGCLPFCTEHL--SGQGCGG-PSLVPLPFQAQ PONPY16_3_PE15 ENSPPYG00000006987 STGQGLAALSEQGWCLCGAVQPSSAS--FACLSLCSGPPPPPAPTCGG-PTLLQHVFPAS PONPY16_3_PE16 ISOFORMIN ------------------------------------------------------------ PROCAGS_6650_PE5 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX PTEVAGS_3466_PE5 NOISO SAGQDLAALSEQGHCLCGVAQPPNTS--SACLPFCSGSPLPHTPACRG-PTLLQNVFPAS RAT10_PE262 NOISO SAGEGLAALSEQNQCLCGAGQPSNTS--AACSSWCSSILLSFNSACGG-PTLLQHTFPAS TETNG18_PE189 ENSTNIG00000014075 AASHRYGGLGGRQECLCSTNSEPNFISESHCSAACTNPQVME-----------VIGA--- TETNG18_PE190 ISOFORMIN AASHRYGGLGGRQECLCSTNSEPNFISESHCSAACTNPQECCWTLAYDVFEVDFSIV--- TURTRGS_3086_PE5 NOISO AAGRGLAALSEQGRCLCGLARPPNAS--SACLPSCSSPPLPPAPTCRG-PTLLQNIFPAS XENTR27_4_PE10 ISOFORMIN CFVDQYTHGAVGPQNGCLCGCAL-AS--NTSSSCHALCEASSSLSNCN-LTIVHDVFRTQ XENTR27_4_PE11 ISOFORMIN CFVDQYTHGAVGPQNGCLCGCAL-AS--NTSSSCHALCEASSSLSNCN-LTIVHDVFRTQ XENTR27_4_PE12 ISOFORMIN CFVDQYTHGAVGPQNGCLCGCAL-AS--NTSSSCHALCEASSSLSNCN-LTIVHDVFRTQ XENTR27_4_PE8 ENSXETG00000015945 CFVDQYTHGAVGPQNGCLCGCAL-AS--NTSSSCHALCEASSSLSNCN-LTIVHDVFRTQ XENTR27_4_PE9 ISOFORMIN ------------------------------------------------------------ MATCH CONSENSUS ????????????????C???????????????????????????????????????????

AILMEGL193445_1_PE11 NOISO PG-AALVGPQGPLASGQLAAFHVT-ASVPVSSTHWDFGDGSPKVDVAGPS----TTHRYV ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO PG-ATLLGPQGPLASGQPAVFHVT-ALLPVSSTHWDFGDGSPEVDVTGPD----ATHRYV CALJA12_3_PE50 ENSCJAG00000015073 SG-AALVGPHGPLASGQPAAFHIA-APLPITAAHWDFGDGSPKVDGAGPV----ALHRYV CANFA6_43_PE42 NOISO PG-AALVGPQGPLASGQPAAFHVT-ASLPVSSTRWDFGDGSPKVDIAGPA----TTHRYL CAVPO4_23_PE41 NOISO PG-TTLVGPHGPLASGQPAAFHISTTSLPLSTICWDFGDGSPKLDMAGPA----ATHRYV CHICK14_PE230 ENSGALG00000005714 LS-VSFIGLKPRYSLHEAVLFNVS-IPIAVSTLIWEFGDQTEVLNTTGNA----AVHTYA CHICK14_PE231 ISOFORMIN LS-VSFIGLKPRYSLHEAVLFNVS-IPIAVSTLIWEFGDQTEVLNTTGNA----AVHTYA DANRE1_57_PE22 NOISO ATTVVVCPPFPIE-NLRKAVLSVA-SSVSPASFSWDFGDLSPRVNTSTPN--TTARHKYG DIPORGS_421_PE4 NOISO PG-ATLVGPHGPLASGRPAAFHIA-APLPIGSTHWDFGDGSPGVDVAGSA----ATHRYA ERIEUGS_1621_PE2 NOISO PG-ATLVGPPGPLASGQPAAFHVS-ALLPVNATRWDFGDGSPEVGVAGPA----TSHRYV FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN ----A--LPLPIQNVHSSISFSAA-SSVAPVTMSWDFGDLSSRVNTSGAGGTTTTSHKYG FUGRU189_PE63 ISOFORMIN ----------LLNPHSGHVDLYTA-SSVAPVTMSWDFGDLSSRVNTSGAGGTTTTSHKYG FUGRU189_PE64 ENSTRUG00000008067 -------FIRDEPKQEGNKRETSA-SSVAPVTMSWDFGDLSSRVNTSGAGGTTTTSHKYG FUGRU189_PE65 ISOFORMIN ----------PIQNVHSSISFSAA-SSVAPVTMSWDFGDLSSRVNTSGAGGTTTTSHKYG GASACGROUPIX_16_PE21 ENSGACG00000018946 ----MVVHSHGNLVFLMRVSFSAA-SSVTPVTLSWDFGDLSSRVNTTESG-CTTATHKYG GORGO16_3_PE27 ENSGGOG00000007016 PG-AALVGPHGPLASGRLAAFHIA-APLPVTATRWDFGDGSPEVDAAGPA----ASHRYV HORSE13_41_PE34 ENSECAG00000006899 PG-AALVGPQGPLASGQPASFHVT-ALLPVSTTRWDFGDDSPEVDVAGPA----TTHRYV HORSE13_41_PE35 ISOFORMIN PG-AALVGPQGPLASGQPASFHVT-ALLPVSTTRWDFGDDSPEVDVAGPA----TTHRYV HS16_PE357 ENSG00000008710 PG-ATLVGPHGPLASGQLAAFHIA-APLPVTATRWDFGDGSAEVDAAGPA----ASHRYV HS16_PE358 ISOFORMIN PG-ATLVGPHGPLASGQLAAFHIA-APLPVTATRWDFGDGSAEVDAAGPA----ASHRYV HS16_PE359 ISOFORMIN ----TLVGPHGPLASGQLAAFHIA-APLPVTATRWDFGDGSAEVDAAGPA----ASHRYV HS16_PE360 ISOFORMIN PG-ATLVGPHGPLASGQLAAFHIA-APLPVTATRWDFGDGSAEVDAAGPA----ASHRYV LOXAF53_15_PE1 NOISO PG-AALEGPLG-LPTGHQAAFRVT-APLPIDSTCWDFGDGSPKVDITGAA----ATHRYL MACEUGS_650_PE4 NOISO LE-ASLLGPGVPQPAGHPVAFNVS-TPLPANNLRWDFGDGAG-I-DTGPA----SSHRFI MICMUGS_282_PE3 NOISO PG-ATLVGPRRPLASGQPAAFHIA-APLPVSSARWDFGDGSPRVDVAGPA----AMHRYV MONDO6_161_PE25 ISOFORMIN ---ASLWGPGGPQPAGHPVVFNVS-TPLPANNLRWDFGDGAPAL-IAGPA----ASHRFI MONDO6_161_PE26 ENSMODG00000016034 LE-ASLWGPGGPQPAGHPVVFNVS-TPLPANNLRWDFGDGAPAL-IAGPA----ASHRFI MONDO6_161_PE27 ISOFORMIN LE-ASLWGPGGPQPAGHPVVFNVS-TPLPANNLRWDFGDGAPAL-IAGPA----ASHRFI MONDO6_161_PE28 ISOFORMIN LE-ASLWGPGGPQPAGHPVVFNVS-TPLPANNLRWDFGDGAPAL-IAGPA----ASHRFI MOUSE17_PE457 NOISO PG-ATLVGPHGPLASGQPADFHIT-SSLPISSTRWNFGDGSPEVDMASPA----ATHFYV MYOLUGS_6259_PE4 NOISO PG-AALVGPQGPLASGQPAAFRVT-ALLPVSSTHWDFGDSSPEVDIAGPA----SVHHYM OCHPRGS_50_PE1 NOISO PG-AVLEGPRGPLASGWPAAFHIA-APLPIQSTHWDFGDGSPKTDTAGSA----TTHRYL ORYLA1073_PE1 NOISO --------APPQQSVHQQIQLSAA-SSVTPITLSWDFGDGSLPLTTAGDG-AGSAVHKYG PIG3_37_PE90 NOISO PG-AALLGPRGPLASGQPAAFRVI-ASLPGSSTRWDFGDGSPEVAVAGPE----ATHRFL POEGU14_10_PE12 NOISO LP-VSFTGLQPRYSLHQPVLFNVS-IPIAASTLLWEFGDRSEVLNTTAHT----AVHSYA PONPY16_3_PE15 ENSPPYG00000006987 PG-AALVGPHGPLASGQLAAFHIA-APLPVTATRWDFGDGSPEVDAAGPA----ASHRYV PONPY16_3_PE16 ISOFORMIN ----ALVGPHGPLASGQLAAFHIA-APLPVTATRWDFGDGSPEVDAAGPA----ASHRYV PROCAGS_6650_PE5 NOISO XX-XXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXX PTEVAGS_3466_PE5 NOISO PG-TTLVGPQGPLASGQLAAFRIT-ASLPISSTHWDFGDGSPEVDITGPT----ATHRYV RAT10_PE262 NOISO PG-AALVGPHGPLASGQPADFHIN-SPLPISSTCWNFGDGSPEVDMAGPA----ATHSYV TETNG18_PE189 ENSTNIG00000014075 ----P--PPLPPQSVHSSVGFSAA-SSVAPVTMSWDFGDLSSRVNTSGSG-VAATAHKYG TETNG18_PE190 ISOFORMIN ----L--EPLPPQSVHSSVGFSAA-SSVAPVTMSWDFGDLSSRVNTSGSG-VAATAHKYG TURTRGS_3086_PE5 NOISO PG-AALVGPQGPLASGQPAAFHVT-ASLPVSSTRWDFGDGSPEVDIAGAD----ATHHYV XENTR27_4_PE10 ISOFORMIN LS-ASVNHFKETYSLVEAVELQVE-APSPITPCHWDFGDQT--VNSTESN----MVHRYA XENTR27_4_PE11 ISOFORMIN LS-ASVNHFKETYSLVEAVELQVE-APSPITPCHWDFGDQT--VNSTESN----MVHRYA XENTR27_4_PE12 ISOFORMIN LS-ASVNHFKETYSLVEAVELQVE-APSPITPCHWDFGDQT--VNSTESN----MVHRYA XENTR27_4_PE8 ENSXETG00000015945 LS-ASVNHFKETYSLVEAVELQVE-APSPITPCHWDFGDQT--VNSTESN----MVHRYA XENTR27_4_PE9 ISOFORMIN --------PFRPHLLVEAVELQVE-APSPITPCHWDFGDQT--VNSTESN----MVHRYA MATCH CONSENSUS ??????????????????????????????????WDFGD?????????????????H?Y?

AILMEGL193445_1_PE11 NOISO LPGRYHVTAVLTLGAGSARLGAEVHVEAAPAALELTCLVSVRSDETLK--LGVRNRGGSD ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO LPGRYPVTAVLALGVGSARLGVEVRVEAAPAALELVCVASVHSEETLQ--LSVRNRGGSG CALJA12_3_PE50 ENSCJAG00000015073 LPGHYRVTAVLALGAGSALLETNVQVEAVPATLELVCPSLVQSDESLQ--LSVRNRGGSG CANFA6_43_PE42 NOISO LPGLYHVTVVLALGAGSAQVETQVHVEAAPASLELTCLTSVRSDETLK--FGIRNRGGSD CAVPO4_23_PE41 NOISO LPGHYHVTAVLTLGASSITLETEVQVEVAPAALELVCPSSVHRDESLE--LSIRNRGGSD CHICK14_PE230 ENSGALG00000005714 LPGQYNVTATLFVGTKVSYVQAEIEVVASPQQLELQCPSLIKTNESLD--IRIRNRGGTG CHICK14_PE231 ISOFORMIN LPGQYNVTATLFVGTKVSYVQAEIEVVASPQQLELQCPSLIKTNESLD--IRIRNRGGTG DANRE1_57_PE22 NOISO VPGRYQAHVSLSAGHQEIM-AQGSVSVELPPRLELHCPDLIVANQSLEAELSLVNWGGVG DIPORGS_421_PE4 NOISO LPGRYHVTAVLAMGSSSALLGTEVRVEAAPAALELLCPASLHSDESLR--ISIRNRGGSA ERIEUGS_1621_PE2 NOISO LPGHYHVTAVLALGAGSAQLGVDVQVEAAPATLELHCPPSVHSDTPLE--LGIRNRGGSG FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN HPGRYLVSLMGWSGNNKVS-AHGEVVVTLPPKLELHCPTLVVANQSLQ--LTLVSWGSVD FUGRU189_PE63 ISOFORMIN HPGRYLVSLMGWSGNNKVS-AHGEVVVTLPPKLELHCPTLVVANQSLQ--LTLVSWGSVD FUGRU189_PE64 ENSTRUG00000008067 HPGRYLVSLMGWSGNNKVS-AHGEVVVTLPPKLELHCPTLVVANQSLQ--LTLVSWGSVD FUGRU189_PE65 ISOFORMIN HPGRYLVSLMGWSGNNKVS-AHGEVVVTLPPKLELHCPTLVVANQSLQ--LTLVSWGSVD GASACGROUPIX_16_PE21 ENSGACG00000018946 LPGHYAVGLMAWAGHKEVRSARAGVTVTLPPKLELRCPPLAVANKSLD--ITLVSWGADG GORGO16_3_PE27 ENSGGOG00000007016 LPGRYHVTAVLALGAGSALLGTDVQVEAAPATLELVCPSSVQSDESLD--LSIRNRGGSG HORSE13_41_PE34 ENSECAG00000006899 LPGRYHVTAVLALG-GSARLGQRCRWSQLPAALELVCLASV-SDETLK--LSVRNRGGSG HORSE13_41_PE35 ISOFORMIN LPGRYHVTAVLALG-GRLSPARAEVQVESAPALELVCLASV-SDETLK--LSVRNRGGSL HS16_PE357 ENSG00000008710 LPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLD--LSIQNRGGSG HS16_PE358 ISOFORMIN LPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLD--LSIQNRGGSG HS16_PE359 ISOFORMIN LPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLD--LSIQNRGGSG HS16_PE360 ISOFORMIN LPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLD--LSIQNRGGSG LOXAF53_15_PE1 NOISO LPGRYWVTARLALGAASAQLATEVWVEAAPAALQLLCPSPVRSNQSLQ--LSVRNRGGTS MACEUGS_650_PE4 NOISO LPGHYNVTAVLTWEARTASLWTEVQVEAVPTELELLCPSWLRNNESLE--FGIRNRGGTG MICMUGS_282_PE3 NOISO LPGRYHVMAVLALGAGSVPLETEVQVEAAPAAVELVCPSLVKSDESLE--LGVLNRGGSG MONDO6_161_PE25 ISOFORMIN LPGHYNVTAVLTLEVGTALLWTEVQVEAVPTELELLCPSWLQSNESLE--IGVRNRGGTG MONDO6_161_PE26 ENSMODG00000016034 LPGHYNVTAVLTLEVGTALLWTEVQVEAVPTELELLCPSWLQSNESLE--IGVRNRGGTG MONDO6_161_PE27 ISOFORMIN LPGHYNVTAVLTLEVGTALLWTEVQVEAVPTELELLCPSWLQSNESLE--IGVRNRGGTG MONDO6_161_PE28 ISOFORMIN LPGHYNVTAVLTLEVGTALLWTEVQVEAVPTELELLCPSWLQSNESLE--IGVRNRGGTG MOUSE17_PE457 NOISO LPGSYHMTVVLALGAGSALLETEVQVEATPTVLELVCPSFVHSNESLE--LGIRHRGGSA MYOLUGS_6259_PE4 NOISO LPGRYHVTAVLALGAGSAQLRTEVQVEAAPAALELMCPASVHSDETLE--LSIRNRGGSG OCHPRGS_50_PE1 NOISO LPGHYHVTALLALGAGSAVLDTEVWVEAAPAALGLVCPPLVRSNESLQ--LGVQNRGGSG ORYLA1073_PE1 NOISO LPGRYIVEVRASAVQKMAL-TQQEVNLTLPPKLELHCPPLVVANQSLE--VTLVSWGGVD PIG3_37_PE90 NOISO LPGRYLVTAVLALGAGSARLHTEVQVQAAPAALELVCLASVHSGETLQ--LGLRNRGGSG POEGU14_10_PE12 NOISO LPGRYNVTATLLVGSRLLQEQAEIEVVASPQQLELQCPSLVVANESLD--IRIRNRGGTG PONPY16_3_PE15 ENSPPYG00000006987 LPGRYHVTAVLALGAGSALLGTNVQVEAAPATLELVCPSSVQSDESLE--LSIQNRGGSG PONPY16_3_PE16 ISOFORMIN LPGRYHVTAVLALGAGSALLGTNVQVEAAPATLELVCPSSVQSDESLE--LSIQNRGGSG PROCAGS_6650_PE5 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXX PTEVAGS_3466_PE5 NOISO LPGHYQVTAVLTLGAGSARLGTEVQVEAAPATLELICPASVHSDETLE--LGIRNRGGSG RAT10_PE262 NOISO LPGGYHVTVVLTLGAGSALLETEVQVEVAPTVLELVCPSFVHSDESLD--LGIRHRGGSA TETNG18_PE189 ENSTNIG00000014075 LPGRYAVTVTGWSGNTKVS-THGDVTVTLPPKLELHCPTLVVANQSLE--VTLVSWGSVG TETNG18_PE190 ISOFORMIN LPGRYAVTVTGWSGNTKVS-THGDVTVTLPPKLELHCPTLVVANQSLE--VTLVSWGSVG TURTRGS_3086_PE5 NOISO LPGRYPVTAVLALGVGSARLWAEVWVEAAPVALELMCLASVHSDETLK--LGVRNRGGSG XENTR27_4_PE10 ISOFORMIN LPGLYNVTVTLVVGDRDVLVNNKVHVVGLPEELQLMCPSLVRTNETLT--VNVSSRGGTE XENTR27_4_PE11 ISOFORMIN LPGLYNVTVTLVVGDRDVLVNNKVHVVGLPEELQLMCPSLVRTNETLT--VNVSSRGGTE XENTR27_4_PE12 ISOFORMIN LPGLYNVTVTLVVGDRDVLVNNKVHVVGLPEELQLMCPSLVRTNETLT--VNVSSRGGTE XENTR27_4_PE8 ENSXETG00000015945 LPGLYNVTVTLVVGDRDVLVNNKVHVVGLPEELQLMCPSLVRTNETLT--VNVSSRGGTE XENTR27_4_PE9 ISOFORMIN LPGLYNVTVTLVVGDRDVLVNNKVHVVGLPEELQLMCPSLVRTNETLT--VNVSSRGGTE MATCH CONSENSUS LPG?Y?V??????G???????????V???P??LEL?CP????????L?????????GG??

AILMEGL193445_1_PE11 NOISO LEATYSIVAVGEAPA-Q----VVHPLCPPDAVIFPGNGHCYRLVAEKAAWLQAQEQCRAW ANOCA1218_PE2 NOISO ------------------------------------------------------------ BOVIN25_3_PE13 NOISO LEAAYSIVALGEEPA-Q----VVHPLCPSDTEIFPGNGHCYSLRAEKASWAQAQEQCRAW CALJA12_3_PE50 ENSCJAG00000015073 LEATYSIVALDEEPT-R----VVHPLCPLDTEIFPGNGHCYRLVVEKAAWLQAQEQCRAW CANFA6_43_PE42 NOISO LEATYSIVAVGEEPA-Q----VVHPLCPSDTVIFPGNGHCYRLVAEKAAWLQAQEQCRAW CAVPO4_23_PE41 NOISO LEATYSILALGEEPV-Q----VVHPLCPSDTEIFPGNGHCYRLVAEKAPWLQAQEQCQAW CHICK14_PE230 ENSGALG00000005714 LTVLYGITAESGEPG-R----AVHPMCPHDGLVFPGNNHCYQLVVEKAEWLEAQQHCQEH CHICK14_PE231 ISOFORMIN LTVLYGITAESGEPG-RA-RAAVHPMCPHDGLVFPGNNHCYQLVVEKAEWLEAQQHCQEH DANRE1_57_PE22 NOISO VTVDWRISKDGREVARDLCVPSAEPQCPPDALHHVDSSRCFLLVSEEVSWAEARRNCSGR DIPORGS_421_PE4 NOISO LEATYTILALDEEPV-R----VVHPLCPSDTEIFPGSGHCYRLVAEKAPWLQAQEQCRTW ERIEUGS_1621_PE2 NOISO LKATYSIVALD--PG-Q----VVHPLCLSDTQIFPGNGHCYRLVAEKAAWLQAQEHCGTW FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN VDVDWKITKHGVQVA------KASPHCPKDGVLHEESSRCFQIVPGELSWTDARKQCLDR FUGRU189_PE63 ISOFORMIN VDVDWKITKHGVQVA------KASPHCPKDGVLHEESSRCFQIVPGELSWTDARKQCLDR FUGRU189_PE64 ENSTRUG00000008067 VDVDWKITKHGVQVA------KASPHCPKDGVLHEESSRCFQIVPGELSWTDARKQCLDR FUGRU189_PE65 ISOFORMIN VDVDWKITKHGVQVA------KASPHCPKDGVLHEESSRCFQIVPGELSWTDARKQCLDR GASACGROUPIX_16_PE21 ENSGACG00000018946 LNVDWKISKDAVTGCECFCPLPACPHFPNNGVCHDESSRCFQIVSGEFSWTDARQQCSDC GORGO16_3_PE27 ENSGGOG00000007016 LEAAYSIVALGEEPA-R----AVHPLCPSDTEIFPGSGHCYRLVVEKAAWLQAQEQCRAW HORSE13_41_PE34 ENSECAG00000006899 -EATYSIMALGEEPA-Q----VVHPLCPSDTEIFPGNGHCYRLVPEKAAWLQAQEQCRAW HORSE13_41_PE35 ISOFORMIN -EATYSIMALGEEPA-Q----VVHPLCPSDTEIFPGNGHCYRLVPEKAAWLQAQEQCRAW HS16_PE357 ENSG00000008710 LEAAYSIVALGEEPA-R----AVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAW HS16_PE358 ISOFORMIN LEAAYSIVALGEEPA-R----AVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAW HS16_PE359 ISOFORMIN LEAAYSIVALGEEPA-R----AVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAW HS16_PE360 ISOFORMIN LEAAYSIVALGEEPA-R----AVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAW LOXAF53_15_PE1 NOISO LAATYSIIALDEEPA-R----VVHPLCPSDTEIFPGNGHCYRLVAEKAAWVQAQEQCRAW MACEUGS_650_PE4 NOISO LSAIYRIMAESEQPA-R----VVHPLCPSDTEIFPGNGHCYRLVVEKASWLQAQRHCQAW MICMUGS_282_PE3 NOISO LEATYSIVALDEEPA-R----VVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCRAW MONDO6_161_PE25 ISOFORMIN LSATYSITAESEQPA-Q----VVHPLCPSNTDIFPGNGHCYRLVVEKAAWLQAQRHCLAW MONDO6_161_PE26 ENSMODG00000016034 LSATYSITAESEQPA-Q----VVHPLCPSNTDIFPGNGHCYRLVVEKAAWLQAQRHCLAW MONDO6_161_PE27 ISOFORMIN LSATYSITAESEQPA-Q----VVHPLCPSNTDIFPGNGHCYRLVVEKAAWLQAQRHCLAW MONDO6_161_PE28 ISOFORMIN LSATYSITAESEQPA-Q----VVHPLCPSNTDIFPGNGHCYRLVVEKAAWLQAQRHCLAW MOUSE17_PE457 NOISO LEVTYSILALDKEPA-Q----VVHPLCPLDTEIFPGNGHCYRLVAEKAPWLQAQEQCRTW MYOLUGS_6259_PE4 NOISO LEATYSIMALGEEPA-Q----VVHPLCPSDTEIFPGNGHCYRLVAEKAAWLQAQEQCWAW OCHPRGS_50_PE1 NOISO LEATYSIMALGEEPA-Q----VVHPLCASDTEIFSGNGHCYRLVAEKAPWLQAQEQCRAW ORYLA1073_PE1 NOISO LDVNWTIAKEGVEVA------K--ARCPNDGVYHAESSSCFQIFTAELNWTDARLQCLNR PIG3_37_PE90 NOISO LEAAYSIMALGEEPA-R----VVHPLCPSDTEIFPGNGRCYRLVAEKAAWLQAQEQCRAW POEGU14_10_PE12 NOISO LAVLYGITAEPGQLG-R----AVHPMCPPEGLVFPGNNHCYQLVVEKAEWLEAQRHCQEL PONPY16_3_PE15 ENSPPYG00000006987 LEAAYSIVALGEEPA-R----VVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCRAW PONPY16_3_PE16 ISOFORMIN LEAAYSIVALGEEPA-R----VVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCRAW PROCAGS_6650_PE5 NOISO XXXXXXXXXXXXXXX-X----XVHPLCPSDTEIFPGNGHCYRLVAEKAAWAQAQEQCRAW PTEVAGS_3466_PE5 NOISO LEATYSIVALNEEPA-Q----VVHPLCPSDTEVFPGNGHCYRLVAEKAAWLQAQEQCRAW RAT10_PE262 NOISO LEVTYSILALDKEPA-Q----VVHPLCPSDTEIFPGNGHCYRLVAEKAPWLQAQEQCRTW TETNG18_PE189 ENSTNIG00000014075 VDIDWKIMKDDVQVA------KASAHCPKDGVLHPESSRCFHIVPGELSWTDARKQCSER TETNG18_PE190 ISOFORMIN VDIDWKIMKDDVQVA------KASAHCPKDGVLHPESSRCFHIVPGELSWTDARKQCSER TURTRGS_3086_PE5 NOISO LEATYSIVALGEEPA-R----VVHPLCPSDTEIFPGNGRCYRLVVEKAAWLQAQEQCRAW XENTR27_4_PE10 ISOFORMIN LTVEYNVTSEGGEE-----VPLVFYMCPPGSIRFSGNNHCYQLVSEKAGWFEARKTCEDL XENTR27_4_PE11 ISOFORMIN LTVEYNVTSEGGEE-----VPLVFYMCPPGSIRFSGNNHCYQLVSEKAGWFEARKTCEDL XENTR27_4_PE12 ISOFORMIN LTVEYNVTSEGGEE-----VPLVFYMCPPGSIRFSGNNHCYQLVSEKAGWFEARKTCEDL XENTR27_4_PE8 ENSXETG00000015945 LTVEYNVTSEGGEEVSCS-VPLVFYMCPPGSIRFSGNNHCYQLVSEKAGWFEARKTCEDL XENTR27_4_PE9 ISOFORMIN LTVEYNVTSEGGEE-----VPLVFYMCPPGSIRFSGNNHCYQLVSEKAGWFEARKTCEDL MATCH CONSENSUS ??????I?????????????????P?CP???????????C??LV?E???W??A???C???

AILMEGL193445_1_PE11 NOISO AGAALAMVGSPAVQRFLVSQVT--RSLDVWIGFSAVEGTE-----AGPAVRAEAFSLESC ANOCA1218_PE2 NOISO ------------------------RSLDVWIGFNDAASGP-----SGASPGEEGFDLQSC BOVIN25_3_PE13 NOISO AGAALAMVDSPAVQHFLVSRVT--RSLDVWIGFSAVEGAA-----AGPAPQGGAFSLESC CALJA12_3_PE50 ENSCJAG00000015073 AGAALAMVDSPAVQRFLVSQVT--RSLDVWIGFSAVQG-------AGPAPQGEAFSLESC CANFA6_43_PE42 NOISO AGAALAMVDSPAIQHFLVSQVT--RSLDVWIGFSAVEGAE-----AGPVVQGAAFSLESC CAVPO4_23_PE41 NOISO AGAALAMVDSPAIQHFLVSQVT--RSLDVWIGFSTVEGAE-----AGLAPQGEAFSLESC CHICK14_PE230 ENSGALG00000005714 GNGELAFVSSPEIQSFLVTHVI-RRSLDVWIGFNDFASS-------EAQQRGEGFNIESC CHICK14_PE231 ISOFORMIN GNGELAFVSSPEIQSFLVTHVI-RRSLDVWIGFNDFASS-------EAQQRGEGFNIESC DANRE1_57_PE22 NOISO -GGELAVVHSQSLRDLLATKITQNLTELIQYQICQAS----EEWPVHE---NNFFSPYRC DIPORGS_421_PE4 NOISO AGAALAMVDSPTIQRFLVSQVT--RGLDVWIGFSSVEGAE-----AGLAPQGEAFSLESC ERIEUGS_1621_PE2 NOISO SGAALAMVDSTAVQRFLISQVT--RSLDVWIGFSAVDGAE-----AGPAPRSEAFSLESC FELCAGS_5159_PE2 NOISO ------------------------------------------------------------ FUGRU189_PE62 ISOFORMIN -GGDLAIVRNDALRNLLARKVTHSMERGVWLGLSDVNSAGKLHWVNGSEAQEGEEGLAPW FUGRU189_PE63 ISOFORMIN -GGDLAIVRNDALRNLLARKVTHSMERGVWLGLSDVNSAGKLHWVNGSEAQEGEEGLAPW FUGRU189_PE64 ENSTRUG00000008067 -GGDLAIVRNDALRNLLARKVTHSMERGVWLGLSDVNSAGKLHWVNGSEAQEGEEGLAPW FUGRU189_PE65 ISOFORMIN -GGDLAIVRNDALRNLLARKVTHSMERGVWLGLSDVNSAGKLHWVNGSEAQEGEEGLAPW GASACGROUPIX_16_PE21 ENSGACG00000018946 -GGNLAIVRSDALRILLAPKITQ--VRGAWLGFSDVDSPGKLRWMDGSDAQEGEEGPPPR GORGO16_3_PE27 ENSGGOG00000007016 AGAALAMVDSPAVQRFLVSRVT--RSLDVWIGFSTVQGVE-----VGPAPQGEAFSLESC HORSE13_41_PE34 ENSECAG00000006899 AGAALAMVDSPAVQHFLISRVT--RSLDVWIGFSAVDGAE-----AGLAPQGEAFSLESC HORSE13_41_PE35 ISOFORMIN AGAALAMVDSPAVQHFLISRVT--RSLDVWIGFSAVDGAE-----AGLAPQGEAFSLESC HS16_PE357 ENSG00000008710 AGAALAMVDSPAVQRFLVSRVT--RSLDVWIGFSTVQGVE-----VGPAPQGEAFSLESC HS16_PE358 ISOFORMIN AGAALAMVDSPAVQRFLVSRVT--RSLDVWIGFSTVQGVE-----VGPAPQGEAFSLESC HS16_PE359 ISOFORMIN AGAALAMVDSPAVQRFLVSRVT--RSLDVWIGFSTVQGVE-----VGPAPQGEAFSLESC HS16_PE360 ISOFORMIN AGAALAMVDSPAVQRFLVSRVT--RSLDVWIGFSTVQGVE-----VGPAPQGEAFSLESC LOXAF53_15_PE1 NOISO AGAALAMVDSPAVQRFLISHVT--RSLDVWIGFSAMEGAEVE---AGSAPRGEAFSLESC MACEUGS_650_PE4 NOISO GRGDLAIVGSPEIQHFLVSQVT--RSLDVWIGFTALTGP-------GVPPHGEAFSLESC MICMUGS_282_PE3 NOISO AGAALAMVDSPAVQRFLVSQVT--RSLDVWIGFSAVQGAE-----AGPAPQGEAFSLESC MONDO6_161_PE25 ISOFORMIN GGGDLAIVGSPEIQRFLVSQVT--RSLDVWIGFTALTGP-------GVPPHGEAFSLESC MONDO6_161_PE26 ENSMODG00000016034 GGGDLAIVGSPEIQRFLVSQVT--RSLDVWIGFTALTGP-------GVPPHGEAFSLESC MONDO6_161_PE27 ISOFORMIN GGGDLAIVGSPEIQRFLVSQVT--RSLDVWIGFTALTGP-------GVPPHGEAFSLESC MONDO6_161_PE28 ISOFORMIN GGGDLAIVGSPEIQRFLVSQVT--RSLDVWIGFTALTGP-------GVPPHGEAFSLESC MOUSE17_PE457 NOISO AGAALAMVDSPAIQHFLVSKVT--RSLDVWIGFSSVEGT------EGLDPRGEAFSLESC MYOLUGS_6259_PE4 NOISO AGAALAMVDSPAIQHFLVSRVT--RGLDVWIGFSAVEGAE-----AGPLSRGEAFSLESC OCHPRGS_50_PE1 NOISO AGAALAMVDSPAVQHFLVSQVT--RSLYVWIVFSAAEGAEL------RAPQGSVFSLKSC ORYLA1073_PE1 NOISO -GGDLAKVRGEALRSLLAHNVTHFMERGVWLGLSDMDSPGKLHWVNGSEVEEN---SPSR PIG3_37_PE90 NOISO AGAALAMVDSPAVQHFLVSRVT--RSLDVWIGFSAVERAE-----IGPAPRDEAFSLESC POEGU14_10_PE12 NOISO GDGDLAFVSSPDIQSFLVAHVI--RSLDVWIGFNDFASS-------GAQQRGEGFNLESC PONPY16_3_PE15 ENSPPYG00000006987 AGAALAMVDSPAVQRFLVSRVT--RSLDVWIGFSTVQGAE-----VGPAPQGEAFSLESC PONPY16_3_PE16 ISOFORMIN AGAALAMVDSPAVQRFLVSRVT--RSLDVWIGFSTVQGAE-----VGPAPQGEAFSLESC PROCAGS_6650_PE5 NOISO AGAALALVDSPAVQRFLITHVT--RSLDVWIGFPAAEGEEEE---AGEAPRGEAFSMESC PTEVAGS_3466_PE5 NOISO AGAALAMVDSPAIQHFLVSRVT--RSLDVWIGFSAVEGTE-----AGTLSQGEAFSLESC RAT10_PE262 NOISO AGAALAMVDSPAIQHFLVSKVT--RSLDVWIGFSSVEGK------EGLDPQGEAFSLESC TETNG18_PE189 ENSTNIG00000014075 -GGDLAVVRNDALRNLLAHKVTHCRERGVWLGLSDVGSAGRLLWVNGSRAQDGEEGLPPR TETNG18_PE190 ISOFORMIN -GGDLAVVRNDALRNLLAHKVT--QERGVWLGLSDVGSAGRLLWVNGSRAQDGEEGLPPR TURTRGS_3086_PE5 NOISO AGAALAMVDSPAVQHFLVSHVT--RSLDVWIGFSAVEGVE-----VGPAPQGEAFSLESC XENTR27_4_PE10 ISOFORMIN GHGNLAIVRSDDVRNFLSNMISPQLPMDLWIGFND---------------SGRNFTLESC XENTR27_4_PE11 ISOFORMIN GHGNLAIVRSDDVRNFLSNMISPQLPMDLWIGFND---------------SGRNFTLESC XENTR27_4_PE12 ISOFORMIN GHGNLAIVRSDDVRNFLSNMISPQLPMDLWIGFND---------------SGRNFTLESC XENTR27_4_PE8 ENSXETG00000015945 GHGNLAIVRSDDVRNFLSNMISPQLPMDLWIGFND---------------SGRNFTLESC XENTR27_4_PE9 ISOFORMIN GHGNLAIVRSDDVRNFLSNMISPQLPMDLWIGFND---------------SGRNFTLESC MATCH CONSENSUS ????LA?V?S??????L???VT??????VWIGF?????????????G???????F?L?SC

AILMEGL193445_1_PE11 NOISO QNWLPGEPHPATAERCVRLGPAGQCNTDLCSVPHSYVCELRPGGPLWDAETFLVGAPSGD ANOCA1218_PE2 NOISO QNWLPGEPHPSNADHCVRMGPAGQCNTDLCTAKHSYLCEHKPPGGFLNAEHFYLGAHAFE BOVIN25_3_PE13 NOISO QNWLPGEPHPATAERCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGAPNGD CALJA12_3_PE50 ENSCJAG00000015073 QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELRPGGPVQDAENFLVGAPSGD CANFA6_43_PE42 NOISO QNWLPGEPHPATAERCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGAPIGD CAVPO4_23_PE41 NOISO QNWLPGEPHPATAEHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFLMGVPGGG CHICK14_PE230 ENSGALG00000005714 QNWLPGEPHPSNADHCVRMGPTGQCNTDLCMAKHSYVCEFKPKGVLLNAENFFVGDPVFD CHICK14_PE231 ISOFORMIN QNWLPGEPHPSNADHCVRMGPTGQCNTDLCMAKHSYVCEFKPKGVLLNAENFFVGDPVFD DANRE1_57_PE22 NOISO EMWGPG-------NVCVSLDGGAQPSIHSCTAKRAFICQFTRHVRVPDAGVSMVGTAVFN DIPORGS_421_PE4 NOISO QNWLPGEPHPATAQHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFLEGVPDGG ERIEUGS_1621_PE2 NOISO QNWLPGEPHPATAKRCVRLGPAGQCNTDLCSTPHSYVCELRPGXXXXXXXXXXXXXXXXX FELCAGS_5159_PE2 NOISO --------------------------------------------PVWDAENFLVGAPPGD FUGRU189_PE62 ISOFORMIN SSVARG-------NLCVSLDQRSQTSSHSCNARRAYVCQYNPQVRVPDSGVFAMGLAVFP FUGRU189_PE63 ISOFORMIN SSVARG-------NLCVSLDQRSQTSSHSCNARRAYVCQYNPQVRVPDSGVFAMGLAVFP FUGRU189_PE64 ENSTRUG00000008067 SSVARG-------NLCVSLDQRSQTSSHSCNARRAYVCQYNPQVRVPDSGVFAMGLAVFP FUGRU189_PE65 ISOFORMIN SSVARG-------NLCVSLDQRSQTSSHSCNARRAYVCQYNPQVPPM-----------VA GASACGROUPIX_16_PE21 ENSGACG00000018946 SSIARG-------NVCVSLDQSAQTSSHPCNAKRAYVCQYNAQVRVPDAGIYTLGLTVFP GORGO16_3_PE27 ENSGGOG00000007016 QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELRPGGPVQDAENLLVGAPSGD HORSE13_41_PE34 ENSECAG00000006899 QNWLPGEPHPATAERCVRLGPAGQCNTDLCSVPHSYVCELRPGGPVWDAENFLVGAPSGD HORSE13_41_PE35 ISOFORMIN QNWLPGEPHPATAERCVRLGPAGQCNTDLCSVPHSYVCELRPGGPVWDAENFLVGAPSGD HS16_PE357 ENSG00000008710 QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGD HS16_PE358 ISOFORMIN QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGD HS16_PE359 ISOFORMIN QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGD HS16_PE360 ISOFORMIN QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGD LOXAF53_15_PE1 NOISO QNWLPGEPHPATAEHCVRLGPAGQCNTDLCSAPHSYVCELQPGGPVWDAENVLMGAPIGD MACEUGS_650_PE4 NOISO QNWLPGEPHPANAEHCVRLGPAGQCNTDLCTATHSYVCEFQPTGAVSNAENFFVGDASLD MICMUGS_282_PE3 NOISO QNWLPGEPHPATAEHCVRLGPAGRCNTDLCSAPHSYVCELRPGGPVWDAENFFVGVPSGD MONDO6_161_PE25 ISOFORMIN QNWLPGEPHPANAEHCVRLGPAGQCNTDLCTATHSYVCEFQPTGIVSSADNFFVGDAGSD MONDO6_161_PE26 ENSMODG00000016034 QNWLPGEPHPANAEHCVRLGPAGQCNTDLCTATHSYVCEFQPTGIVSSADNFFVGDAGSD MONDO6_161_PE27 ISOFORMIN QNWLPGEPHPANAEHCVRLGPAGQCNTDLCTATHSYVCEFQPTGIVSSADNFFVGDAGSD MONDO6_161_PE28 ISOFORMIN QNWLPGEPHPANAEHCVRLGPAGQCNTDLCTATHSYVCEFQPTGIVSSADNFFVGDAGSD MOUSE17_PE457 NOISO QNWLPGEPHPATAEHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDTENFVMGMSGGG MYOLUGS_6259_PE4 NOISO QNWLPGEPHPATAERCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFLLGAPSGD OCHPRGS_50_PE1 NOISO QNWLPGEPHPATAEHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGVPRGE ORYLA1073_PE1 NOISO PDISPG-------NACVSLDQDSQISSHLCSSKRVYMCQYTLPVRVQDGGVFILGMPVFP PIG3_37_PE90 NOISO QNWLPGEPHPATAERCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFFVGAPSGD POEGU14_10_PE12 NOISO QNWLPGEPHPSNADHCVRMGPTGQCNTDLCMAKHSYVCEYKPPGVLLNAENFFEGEAELG PONPY16_3_PE15 ENSPPYG00000006987 QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELRPGGPVQDAENLLVGAPSGD PONPY16_3_PE16 ISOFORMIN QNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELRPGGPVQDAENLLVGAPSGD PROCAGS_6650_PE5 NOISO QN-LPGEPHQATDEQCLRIGHAGQCNTDLCSAPHSFVNEMRPGGPVWDAENVLVGAPSGD PTEVAGS_3466_PE5 NOISO QNWLPGEPHPATAERCVRLGPAGQCNTDLCSASHSYVCELRPGGPVWDSENFLVGAPSGD RAT10_PE262 NOISO QNWLPGEPHPATEEHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVGDADNFLLGVSGGG TETNG18_PE189 ENSTNIG00000014075 SPVAHG-------NVCVSLDQRGQTSSHSCTAKRAYVCQYNPQVHVPDSGVFAMGLAVFP TETNG18_PE190 ISOFORMIN SPVAHG-------NVCVSLDQRGQTSSHSCTAKRAYVCQYNPQ----DSGVFAMGLAVFP TURTRGS_3086_PE5 NOISO QNWLPGEPHPATAERCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGAPSGD XENTR27_4_PE10 ISOFORMIN QNWLPGQPEPSQADRCVMMGRSGVCNTDLCSSKHSYVCEYKPQGKSDHILS-LC-GGIL- XENTR27_4_PE11 ISOFORMIN QNWLPGQPEPSQADRCVMMGRSGVCNTDLCSSKHSYVCEYKPQDLQLNADY-FVLGSLS- XENTR27_4_PE12 ISOFORMIN QNWLPGQPEPSQADRCVMMGRSGVCNTDLCSSKHSYVCEYKPQGKSDHILS-LCGVLYMQ XENTR27_4_PE8 ENSXETG00000015945 QNWLPGQPEPSQADRCVMMGRSGVCNTDLCSSKHSYVCEYKPQGKSDHILS-LCGVLYMQ XENTR27_4_PE9 ISOFORMIN QNWLPGQPEPSQADRCVMMGRSGVCNTDLCSSKHSYVCEYKPQGKSDHILS-LCGVLYMQ MATCH CONSENSUS QNWLPG?P???????CV??G??G?CNTDLC???HSYVCE??P????????????G?????

AILMEGL193445_1_PE11 NOISO LQGPLSPLAE-QEALSAPQELV---E---------------------VMAFPSLHLSREA ANOCA1218_PE2 NOISO SYLPTGNVTE-TEELSAPLGTI---E---------------------TLVFPMLTSPREG BOVIN25_3_PE13 NOISO LQGPLSPLEQ-QEALLAPQEPV---E---------------------VMAFPGLSPSREA CALJA12_3_PE50 ENSCJAG00000015073 LQGPLIPLVQ-QDDLSAPRQPV---E---------------------VMVFPVLSLSQEA CANFA6_43_PE42 NOISO LQGPLSPLAQ-QEALSAPQELI---E---------------------VMVFPSLGLSREA CAVPO4_23_PE41 NOISO LQGPLILLTP-QEALLPPRWPV---E---------------------VMVFPGLSPSREA CHICK14_PE230 ENSGALG00000005714 THVAAKNVIE--DTLSSPLQAV---E---------------------VMVFPELAFRHEG CHICK14_PE231 ISOFORMIN THVAAKNVIE--DTLSSPLQAV---E---------------------VMVFPELAFRHEG DANRE1_57_PE22 NOISO THNPLRSPAV--SHTSVPNTPA------------------------RLLLFAGLSFVSAG DIPORGS_421_PE4 NOISO LQGPLRPLAR-QEALLAPQQPL---E---------------------LIVLPG--PSREA ERIEUGS_1621_PE2 NOISO XXXXXXXXXX-XXXXXXXXXXX---XX-XX-----------------XXXXXXXXXXXXX FELCAGS_5159_PE2 NOISO LQGPLSPLAQ-QEALSAPQEPV---E---------------------VMVFPSLGLSREA FUGRU189_PE62 ISOFORMIN SHHLLQATAA--M-ITTPPPPHGGVEV---------------------LLFPALSFVRAG FUGRU189_PE63 ISOFORMIN SHHLLQATAA--M-ITTPPPPHGGVEV---------------------LLFPALSFVRAG FUGRU189_PE64 ENSTRUG00000008067 SHHLLQATAA--M-ITTPPPPHGGVEV---------------------LLFPALSFVRAG FUGRU189_PE65 ISOFORMIN EHVSLAATAA--M-ITTPPPPHGGVEVRMNPQQGIATIRNHHPAPPTVLLFPALSFVRAG GASACGROUPIX_16_PE21 ENSGACG00000018946 SHNPLHRAAP--APLSTPQPPRGGVEV---------------------LLFPAMSCVRAG GORGO16_3_PE27 ENSGGOG00000007016 LQGPLTPLAQ-QDGLSAPHEPV---E---------------------VMVFPGLRLSREA HORSE13_41_PE34 ENSECAG00000006899 LQGPLSPLAH-QEALSAAQEPV---E---------------------VMVFPGLGLSREA HORSE13_41_PE35 ISOFORMIN LQGPLSPLAH-QEALSAAQEPV---E---------------------VMVFPGLGLSREA HS16_PE357 ENSG00000008710 LQGPLTPLAQ-QDGLSAPHEPV---E---------------------VMVFPGLRLSREA HS16_PE358 ISOFORMIN LQGPLTPLAQ-QDGLSAPHEPV---E---------------------VMVFPGLRLSREA HS16_PE359 ISOFORMIN LQGPLTPLAQ-QDGLSAPHEPV---EA-GM-----GSVELRRPPAHQVMVFPGLRLSREA HS16_PE360 ISOFORMIN LQGPLTPLAQ-QDGLSAPHEPV---E---------------------VMVFPGLRLSREA LOXAF53_15_PE1 NOISO LQGPLSPLVQ-QEALAAPQEPV---E---------------------VMVFPGLSLRHEA MACEUGS_650_PE4 NOISO LPGPMVPLEE-QDVLSAPGHET---VE--------------------VMIFPGLVLQRKG MICMUGS_282_PE3 NOISO LQGPLSPLAQ-QEVLSAPREPV---E---------------------VMVFPSLSLSQEA MONDO6_161_PE25 ISOFORMIN LPGPTVPVEE-RDFLSAPGRET---VE-----------VTPLSLSVQVMIFPGLEMQQKG MONDO6_161_PE26 ENSMODG00000016034 LPGPTVPVEE-RDFLSAPGRET---VE--------------------VMIFPGLEMQQKG MONDO6_161_PE27 ISOFORMIN LPGPTVPVEE-RDFLSAPGRET---VE--------------------VMIFPGLEMQQKG MONDO6_161_PE28 ISOFORMIN LPGPTVPVEE-RDFLSAPGRET---VE--------------------VMIFPGLEMQQKG MOUSE17_PE457 NOISO LSGPLHPLAQ-QETVQGPLRPV---E---------------------VMVFPGLSPSREA MYOLUGS_6259_PE4 NOISO LQGPLSPLAQ-QEALSAPWEPV---E---------------------XXXXXXXXXXXEA OCHPRGS_50_PE1 NOISO IQGPPRLLAS-QSMLQVPREPV---E---------------------VMVFPGLHLHREA ORYLA1073_PE1 NOISO THSPLHLASA--ILSSAPQPPKSAIEM---------------------LLFPALSFLQEG PIG3_37_PE90 NOISO LQAPLSPLAQ-QEALSAPQEPV---E---------------------VMVFPGLSPSREA POEGU14_10_PE12 NOISO TEEAVRSVSE--AVLADPWQAE---E---------------------VLEFPELAFRHQG PONPY16_3_PE15 ENSPPYG00000006987 LQGPLTPLAQ-QDGLSAPHQPV---E---------------------VMVFPGLSPSHEA PONPY16_3_PE16 ISOFORMIN LQGPLTPLAQ-QDGLSAPHQPV---EA-GV-----GSVELRQLPVHQVMVFPGLSPSHEA PROCAGS_6650_PE5 NOISO LQGPLSPLLP-QEVLAAPQEAV---E---------------------VMVFPGLSLRREA PTEVAGS_3466_PE5 NOISO LQEPLSPLAQ-QEALSAPQELV---E---------------------VMVFPGLGLHEAF RAT10_PE262 NOISO RSGPLQPLAQ-QGTLQGPLQPV---E---------------------VMVFPGLSPSQEA TETNG18_PE189 ENSTNIG00000014075 PHRLLHAAAA--T-GAAPPPPSGGVEV---------------------LLFPALSFVQAG TETNG18_PE190 ISOFORMIN PHRLLHAAAA--T-GAAPPPPSGGVEV---------------------LLFPALSFVQAG TURTRGS_3086_PE5 NOISO LQGPLSPLVQ-QEALTAPREPV---E---------------------VMVFPGLSPSREA XENTR27_4_PE10 ISOFORMIN -FCPIPC--------------M---HLARG-----WMAPFLYSVFPQVLVFPGVQFAQDV XENTR27_4_PE11 ISOFORMIN -GESRPL--------------K---NLQRS-----NNLSLPYGNEVEVLVFPGVQFAQDV XENTR27_4_PE12 ISOFORMIN LRQYLPC--------------M---MF--------WEEMTSNKRAVEVLVFPGVQFAQDV XENTR27_4_PE8 ENSXETG00000015945 LRQYLPC--------------M---MF--------WEEMTSNKRAVEVLVFPGVQFAQDV XENTR27_4_PE9 ISOFORMIN LRQYLPCMMFWEGILFCPIPCM---HLARG-----WMAPFLYSVFPQVLVFPGVQFAQDV MATCH CONSENSUS ?????????????????P????????????????????????????????FP?L??????

AILMEGL193445_1_PE11 NOISO FLTAVEFGTQELPRPAQVRLQVLRPTGQ-A---------GAPGS-SREPESR-SPESQTE ANOCA1218_PE2 NOISO FLLALELATRELQRRVQVRFRLHHPAHGEA---------GPD---SPEDWNGTDPLQEMQ BOVIN25_3_PE13 NOISO FLTAAEFGTQELGRPAQLRLQVYRAGRG-A---------GAPGN-SSEPQGR-SLENRTE CALJA12_3_PE50 ENSCJAG00000015073 FLTTAEFGTQELLQPAQLRLQVYRPLST-A---------GTPEN-GSEPESG-FRDNRTQ CANFA6_43_PE42 NOISO FLTAAEFGTQELRRPTQLRLQVFRPVGE-A---------GAPGN-SREPESG-SRESRTE CAVPO4_23_PE41 NOISO FLTTAEFETQELGGPAQLRLQVYRPSGR-A---------GAPEN-RSEP------DNRTE CHICK14_PE230 ENSGALG00000005714 YLSALEFVTQELHQPIQMRFQVHRPIDGKE---------YQEGQNATEPFPTSQ-DDGNY CHICK14_PE231 ISOFORMIN YLSALEFVTQELHQPIQMRFQVHRPIDGKE---------YQEGQNATEPFPTSQ-DDGNY DANRE1_57_PE22 NOISO RLSSLEFVTHSLDTHTQVRFQVYRPRCPSFTHTLLPA-----------PDEW-MNSTEAP DIPORGS_421_PE4 NOISO FLTAAEFGIQELGGPAQLRLQVFRPSGG-A---------VAPES-SSEP------ENVTE ERIEUGS_1621_PE2 NOISO XXXXXXXXXXXXXXXXXXXXXXXX--XX-X---------XXXXX-XXXXXXX-XXXXXXX FELCAGS_5159_PE2 NOISO FLIAAEFGTXXXXXXXXXXXXXXXXXXX-X---------XXXXX-XXXXXXX-XXXXXXX FUGRU189_PE62 ISOFORMIN RLSSLEFVTRELSSQTHILFQIYRPRCRHP------CCCGGPAC-SPMALCV-PSESRSA FUGRU189_PE63 ISOFORMIN RLSSLEFVTRELSSQTHILFQIYRPRCRYPGLHLLLPSCGGPAC-SPMALCV-PSESRSA FUGRU189_PE64 ENSTRUG00000008067 RLSSLEFVTRELSSQTHILFQIYRPRCRYPGLHLLLPNLS-----------T-ENESRSA FUGRU189_PE65 ISOFORMIN RLSSLEFVTRELSSQTHILFQIYRPRCRYPGLHLLLPSCGGPAC-SPMALCV-PSESRSA GASACGROUPIX_16_PE21 ENSGACG00000018946 RLSSLEFVAPELRSQIHVRFQTYRPYC-----------CGGPAC-APVAVCV-PNDTRSG GORGO16_3_PE27 ENSGGOG00000007016 FLTTAEFGTQELRRPAQLRLQVYRLLST-A---------GTPEN-GSEPESR-SPDNRTQ HORSE13_41_PE34 ENSECAG00000006899 FLTTAEFGTQELGRPAQLRLQVYRPLGG-A---------GASEN-SSEPESR-SLENRTE HORSE13_41_PE35 ISOFORMIN FLTTAEFGTQELGRPAQLRLQVYRPLGG-A---------GGP------PSQL-SLENRTE HS16_PE357 ENSG00000008710 FLTTAEFGTQELRRPAQLRLQVYRLLST-A---------GTPEN-GSEPESR-SPDNRTQ HS16_PE358 ISOFORMIN FLTTAEFGTQELRRPAQLRLQVYRLLST-A---------GTPEN-GSEPESR-SPDNRTQ HS16_PE359 ISOFORMIN FLTTAEFGTQELRRPAQLRLQVYRLLST-A---------GTPEN-GSEPESR-SPDNRTQ HS16_PE360 ISOFORMIN FLTTAEFGTQELRRPAQLRLQVYRLLST-A---------GTPEN-GSEPESR-SPDNRTQ LOXAF53_15_PE1 NOISO FLTAAEFGTQALERPAQLRLQVFRPAGS-T---------GAPEN-SSEPKSR-SLDNGTV MACEUGS_650_PE4 NOISO FLTAAEFGTQDLTEPVQMRLQVYRPVGG-----------GIPEN-TSQLSCP-PLDNQTW MICMUGS_282_PE3 NOISO FLTTAEFGTQELRRPAQLRLQVHRLVGG-T---------GVPEN-SSEPESG-SLDNKTE MONDO6_161_PE25 ISOFORMIN FLTAAEFETQDLMQPVQMRLQVYRPVEG-----------GIPEN-SSQPLCP-SMDNQTW MONDO6_161_PE26 ENSMODG00000016034 FLTAAEFETQDLMQPVQMRLQVYRPVEG-----------GIPEN-SSQPLCP-SMDNQTW MONDO6_161_PE27 ISOFORMIN FLTAAEFETQDLMQPVQMRLQVYRPVEG-----------GIPEN-SSQPLCP-SMDNQTW MONDO6_161_PE28 ISOFORMIN FLTAAEFETQDLMQPVQMRLQVYRPVEG-----------GIPEN-SSQPLCP-SMDNQTW MOUSE17_PE457 NOISO FLTAAEFSTQKLEEPAQMRLQVYRPSGGAA---------AVPEG-SSEP------DNRTE MYOLUGS_6259_PE4 NOISO FLTAAEFGTQELGRPAQMRLQVYRPMGG-A---------GVSAN-SSEPESR-SLENRTE OCHPRGS_50_PE1 NOISO FLTAAEFETLELRQPAQLRLQVYRPSGA-E---------GASGN-STEPEGR-SLENKFQ ORYLA1073_PE1 NOISO RLSSLEFVTQELSSQVQVRLQIFRPHCPHQKQHLLLPGCGGLVC-APVAVCV-PDDRSND PIG3_37_PE90 NOISO FLTAAEFGTQTLGRPAQLRLQVYRPLGG-A---------GALRN-SSEPQSR-SSENRTE POEGU14_10_PE12 NOISO FLTALEFVTQELHQPVQVRFQVWFCSFEE-----------------IKPWGSGL-EKITE PONPY16_3_PE15 ENSPPYG00000006987 FLTAAEFGTQELRRPAQLRLQVYRLLST-A---------GTPEN-GSEPESR-SLDNRTQ PONPY16_3_PE16 ISOFORMIN FLTAAEFGTQELRRPAQLRLQVYRLLST-A---------GTPEN-GSEPESR-SLDNRTQ PROCAGS_6650_PE5 NOISO FLTSAEFATQVLGRPAQLRLQVFRLEGS-S---------GAPGN-SSEPGSR-SLDNDTV PTEVAGS_3466_PE5 NOISO LIXXXXXXXXXXXXXXXXXXXXXXXXXX-X---------XXXXX-XXXXXXX-XXXXXXX RAT10_PE262 NOISO FLTAAEFETQELEDPVQLRLQVYRHSRE-A---------VAPEG-SSEL------DNSTE TETNG18_PE189 ENSTNIG00000014075 HLSSLEFLTRELSSPTRVWFQIYRPHCHKP------G-IGGAAC-SPMALCV-SGDSGSQ TETNG18_PE190 ISOFORMIN HLSSLEFLTRELSSPTRVWFQIYRPHCQ----------IGGAAC-SPMALCV-SGDSGSQ TURTRGS_3086_PE5 NOISO FLTAAEFGTRELGGPAQLRLQVYRAMRG-T---------GAPGN-SSEPQSR-SLENRTE XENTR27_4_PE10 ISOFORMIN YLSALELEAKELQRSVQMKFQVYLQDDN-H------------ECNADTPTSLPIIQDVKQ XENTR27_4_PE11 ISOFORMIN YLSALELEAKELQRSVQMKFQVYLQDDN-H----------------DTPTSLPIIQDVKQ XENTR27_4_PE12 ISOFORMIN YLSALELEAKELQRSVQMKFQVYLQDDN-H------------ECNADTPTSLPIIQDVKQ XENTR27_4_PE8 ENSXETG00000015945 YLSALELEAKELQRSVQMKFQVYLQDDN-H------------ECNADTPTSLPIIQDVKQ XENTR27_4_PE9 ISOFORMIN YLSALELEAKELQRSVQMKFQVYLQDDN-H---------GELECNADTPTSLPIIQDVKQ MATCH CONSENSUS ?L???EF?T??L????Q???Q??R????????????????????????????????????

AILMEGL193445_1_PE11 NOISO SVPACAPEGCWCPRASLPLPLDDPCRPRA-CANGSTSGL--------ELPGASCVLWKEF ANOCA1218_PE2 NOISO LQMDCPSGSHWCQLTNSCLPLGGCCNKFESCANSSMASTPSPIAHRC-PNPPSMVQVQES BOVIN25_3_PE13 NOISO LAPVCAPEGPLCPQANVCLPLDTPCHPGA-CANGSMPGP--------GLPGVSYVLQKEF CALJA12_3_PE50 ENSCJAG00000015073 PAPECMPGGCWCPGANVCLPLDASCHSQA-CANSCMSGP--------GLPKAPYMLWREF CANFA6_43_PE42 NOISO SVPECTPEGRWCPRASIHLPPDDPCGPWA-CANGSMSGP--------GLPGASCVLLREF CAVPO4_23_PE41 NOISO PVPRCMPEGCWCPGASLCMPLDAACHLQA-CANESVVEP--------GLPRATYALWREF CHICK14_PE230 ENSGALG00000005714 TLVECPPGFQWCHLTNLCSSVNNCCNAME-CTNSSFASSPIPASPQHKGSQLSYELVKEF CHICK14_PE231 ISOFORMIN TLVECPPGFQWCHLTNLCSSVNNCCNAME-CTNSSFASSPIPASPQHKGSQLSYELVKEF DANRE1_57_PE22 NOISO AAPGCPAERHFCPFSERCVSLSSPCPSSA-CFNCSGVSPPPA-----GTQYPEYSLLDEV DIPORGS_421_PE4 NOISO PGPGCLLEEHWCPGANVCVPVDASCHPHA-PARGSASGP--------RLPGVAHTLWREF ERIEUGS_1621_PE2 NOISO XXXXXXXXXXXXXIANVCLPLDVPCFPWA-CTRGSASTA--------GLPTVSYLLWREF FELCAGS_5159_PE2 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX--------XXXXXXXXXXXXX FUGRU189_PE62 ISOFORMIN DPPSCPKLEQWCPFQHRCLPLSSPCQPSS-CLNCSQGHQLPS-----EARMPLYTLQYEV FUGRU189_PE63 ISOFORMIN DPPSCPKLEQWCPFQHRCLPLSSPCQPSS-CLNCSQGHQLPS-----EARMPLYTLQYEV FUGRU189_PE64 ENSTRUG00000008067 DPPSCPKLEQWCPFQHRCLPLSSPCQPSS-CLNCSQGHQLPS-----EARMPLYTLQYEV FUGRU189_PE65 ISOFORMIN DPPSCPKLEQWCPFQHRCLPLSSPCQPSS-CLNCSQGHQLV------------------- GASACGROUPIX_16_PE21 ENSGACG00000018946 DPSSCPRLEQWCPFQRRCLPLLSPCRPSA-CPNCTQGHLLPP-----GARRPRYTLQNEV GORGO16_3_PE27 ENSGGOG00000007016 LVPACMPGGCWCPGANICLPLDASCHPQA-CANGCTSGP--------GLPGAPYALWREF HORSE13_41_PE34 ENSECAG00000006899 PAPVCTPEGRWCPRSNICLPLDAPCHPQT-CANGSTSGP--------GLPGVSYALWREF HORSE13_41_PE35 ISOFORMIN PAPVCTPEGRWCPRSNICLPLDAPCHPQT-CANGSTSGP--------GLPGVSYALWREF HS16_PE357 ENSG00000008710 LAPACMPGGRWCPGANICLPLDASCHPQA-CANGCTSGP--------GLPGAPYALWREF HS16_PE358 ISOFORMIN LAPACMPGGRWCPGANICLPLDASCHPQA-CANGCTSGP--------GLPGAPYALWREF HS16_PE359 ISOFORMIN LAPACMPGGRWCPGANICLPLDASCHPQA-CANGCT------------------------ HS16_PE360 ISOFORMIN LAPACMPGGRWCPGANICLPLDASCHPQA-CANGCTSGP--------GLPGAPYALWREF LOXAF53_15_PE1 NOISO PAPSCMPEGSWCPVANICIPLDTPRHPRA-CVSGSWPGL--------RLSGAAYVLWKEF MACEUGS_650_PE4 NOISO VPLECLAGEHWCPLANMCLPLDSPCSIS--CVNDSSSER---------QPLVHYSLWREF MICMUGS_282_PE3 NOISO LAPECVPEGCWCPGANACVPLDATCHPRA-CASGFTSGP--------GLHGAAYTLWREF MONDO6_161_PE25 ISOFORMIN VPLDCLPGEHWCPLANLCLPLDSPCSLSP-CANDSSPEQD-------NHC---------- MONDO6_161_PE26 ENSMODG00000016034 VPLDCLPGEHWCPLANLCLPLDSPCSLSP-CANDSSPEQD-------NHWSGHYSLWREF MONDO6_161_PE27 ISOFORMIN VPLDCLPGEHWCPLANLCLPLDSPCSLSP-CANDSSPEQD-------NHWSGHYSLWREF MONDO6_161_PE28 ISOFORMIN VPLDCLPGEHWCPLANLCLPLDSPCSLSP-CANDSSPEQD-------NHWSGHYSLWREF MOUSE17_PE457 NOISO PAPKCVPEELWCPGANVCIPFDASCNSHV-CINGSVSRL--------GLSRASYTLWKEF MYOLUGS_6259_PE4 NOISO LAPDCTPEGVWCPRSNICLPLDTPCYPQ---ANGSTAGP--------GLPGASYTLWREF OCHPRGS_50_PE1 NOISO PATEGLSQGCSCPGV--------KCLSRD-CANRSASGL--------WRPAAAYVLWREF ORYLA1073_PE1 NOISO DPPSCPRLEQWCPFLSSCQPLSSPCHPSS-CQNCTHAHYLPP-----GMWRPLYILQNEV PIG3_37_PE90 NOISO P-PACTPAGHPCPRANVCLPLGAPCHLQA-CANTSTAGL--------GLPGVASALWKEF POEGU14_10_PE12 NOISO EKPLSMPEESWCPLTSLCSSHNSCCNGTE-CANSSFGSSPAPGAPQPSDSQPSRELLKEL PONPY16_3_PE15 ENSPPYG00000006987 LAPACMPGGRWCPGANVCLPLDASCHPQA-CANGCTSGP--------GLPGAPYALWREF PONPY16_3_PE16 ISOFORMIN LAPACMPGGRWCPGANVCLPLDASCHPQA-CANGCT------------------------ PROCAGS_6650_PE5 NOISO LAPGCLPEESGCPVANVCVPLDMPGHSEA-CVNGSMPEP--------GLSRAAYVLWKEL PTEVAGS_3466_PE5 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX--------XXXXXXXXXXXXX RAT10_PE262 NOISO PAPKCVPEELWCPGANVCVPFDALCNSHV-CINGSASRL--------GLPRASYTLWKEF TETNG18_PE189 ENSTNIG00000014075 GSPSCPPLEQWCPFQRRCLPLASPCQPSS-CLNCSNGHQLPP-----GARLPGYQLQSEV TETNG18_PE190 ISOFORMIN GSPSCPPLEQWCPFQRRCLPLASPCQPSS-CLNCSNGHQLPP-----GARLPGYQLQSEV TURTRGS_3086_PE5 NOISO PIPTCTPEGHPCPRSNICLPLDTPCHLRA-CANGSTSGL--------GLPGVSYALWKEF XENTR27_4_PE10 ISOFORMIN SQSECEEGHETSNSTNSSLPLGSGCAPAKEIEYTTPASPQPGIGSPSYVLQRELNLVIPP XENTR27_4_PE11 ISOFORMIN SQSECEEGHETSNSTNSSLPLGSGCAPAKEIEYTTPASPQPGIGSPSYVLQRELNLVIPP XENTR27_4_PE12 ISOFORMIN SQSECEEGHETSNSTNSSLPLGSGCAPAKEIEYTTPASPQPGIGSPSYVLQRELNLVIPP XENTR27_4_PE8 ENSXETG00000015945 SQSECEEGHETSNSTNSSLPLGSGCAPAKEIEYTTPASPQPGIGSPSYVLQRELNLVIPP XENTR27_4_PE9 ISOFORMIN SQSECEEGHETSNSTNSSLPLGSGCAPAA------------------------------- MATCH CONSENSUS ????C??????C?????C?PL???C?????C????????????????????????L????

AILMEGL193445_1_PE11 NOISO LFSVPAGPPAQYAITFRGQDSPLLPGDLIALQHDAGPGALLRCSPAL---GAPGAEAPQ- ANOCA1218_PE2 NOISO LFIVPPGPSMMYLLLFKNKDVSIGPNDTLSIQHDAGPGAFLLCHRNR----VPSSPTSYF BOVIN25_3_PE13 NOISO LFSVPAGPPAQYSVPFHGQDIALLPGDLVILQHDAGPGTLLRCPPAL---SFPGSEAPYF CALJA12_3_PE50 ENSCJAG00000015073 LFSVPAGPPAQYSVTLHGQDVLMLPGDLVSLQHDAGPGAFLHCPLAS---SSPGLQAPYL CANFA6_43_PE42 NOISO LFSVPAGPPSQYSVTFRGQDGPLKPGDLIALQHDAGPGALLCCSPAL---GAPGAEAPYF CAVPO4_23_PE41 NOISO LFSVPAGPPTQYLVTFHGQDVPVLPGDLIGLQHDAGSGALLQCPLTP---NQAGSKVLYL CHICK14_PE230 ENSGALG00000005714 LFTIPAGPSAPYLVTFSKEDVFVRAKDVLSIQHNAGMGSFLQCQPST----TSPFRTNYF CHICK14_PE231 ISOFORMIN LFTIPAGPSAPYLVTFSKEDVFVRAKDVLSIQHNAGMGSFLQCQPST----TSPFRTNYF DANRE1_57_PE22 NOISO LISLPAGPAASVLVQEEVQDLLVSPGDIIALQHDAGPSGLLQCSPDP----SSPWSQSLL DIPORGS_421_PE4 NOISO LFSVPAGPPTRYSVTVHDQDILVLPGDLIGLQHDAGPGALLQCPLGS---NHPGLEVLYF ERIEUGS_1621_PE2 NOISO LFSVPAGPPTQYSATFHDLDDPLLPGDLFSLQHDGGPGALLHCPLAL---SCPGPTAPYF FELCAGS_5159_PE2 NOISO XXXXXXXXXXXXXVPFQGQDGPLLPGDLVTLQHDAGPGALLHCSPAL---GPPGPEAPYL FUGRU189_PE62 ISOFORMIN LFSLTAGPAAHVLLQDQLEDLLVSRGDVIALQHDAGPASLIHCQSSP----HSLWRQPVF FUGRU189_PE63 ISOFORMIN LFSLTAGPAAHVLLQDQLEDLLVSRGDVIALQHDAGPASLIHCQSSP----HSLWRQPVF FUGRU189_PE64 ENSTRUG00000008067 LFSLTAGPAAHVLLQDQLEDLLVSRGDVIALQHDAGPASLIHCQSSP----HSLWRQPVF FUGRU189_PE65 ISOFORMIN ------------------------------------------------------------ GASACGROUPIX_16_PE21 ENSGACG00000018946 VFTLPPGPAAHVLVREHLEDLLVSPGDIIALQHDAGPASLLHCKSSP----HSMWRQPVF GORGO16_3_PE27 ENSGGOG00000007016 LFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPSALLHCSPAP---SHPGPQAPYL HORSE13_41_PE34 ENSECAG00000006899 LFSVPAGPPAQYSVTFHGQDGPVLPGDLISLQHDAGPGALLHCPPAL---GHPGPEAPYF HORSE13_41_PE35 ISOFORMIN LFSVPAGPPAQYSVTFHGQDGPVLPGDLISLQHDAGPGALLHCPPAL---GHPGPEAPYF HS16_PE357 ENSG00000008710 LFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAP---GHPGPRAPYL HS16_PE358 ISOFORMIN LFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAP---GHPGPRAPYL HS16_PE359 ISOFORMIN ------------------------------------------------------------ HS16_PE360 ISOFORMIN LFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAP---GHPGPRAPYL LOXAF53_15_PE1 NOISO LLSVPAGPPTQYWIAFQDQDTPLLPGDLLALQHDAGPGTFLHCPPAQ---GPPAPEAPYL MACEUGS_650_PE4 NOISO LFSIPAGPSLQYSVSFSSKNLSLLPGDLFGIQHDAGPGALLHCLPRHEALTHLHLQSECL MICMUGS_282_PE3 NOISO LFSIPAGPPAQYSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XHSGLHAPYL MONDO6_161_PE25 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE26 ENSMODG00000016034 LFSLPAGPSSQYSVSFSGKNISLLPGDLFSLQHDAGPGSLLRFLPRPEALPHQRFQPECL MONDO6_161_PE27 ISOFORMIN LFSLPAGPSSQYSVSFSGKNISLLPGDLFSLQHDAGPGSLLRFLPRPEALPHQRFQPECL MONDO6_161_PE28 ISOFORMIN LFSLPAGPSSQYSVSFSGKNISLLPGDLFSLQHDAGPGSLLRFLPRPEALPHQRFQPECL MOUSE17_PE457 NOISO FFSVPAGPPTQYLVTLHSQDVPMLPGDLIGLQHDAGPGTLLQCPLAS---SCPG-QALYL MYOLUGS_6259_PE4 NOISO LFSVPAGPPAQYSVALRGQDGPLLPGDLIGFQHDAGPGALLRCTSAL---SHSGPEAPYF OCHPRGS_50_PE1 NOISO LLAVPAGPPAYYSVSFSDQDAPMLPGDLVGLQHDAGPGAFLHCPLAP---SHPGLEARYL ORYLA1073_PE1 NOISO ELRLPIGPSAHILIQDQLEDLLVSGGDVIALQHDGGPSSLLQCQSSA----QSPWGQPIL PIG3_37_PE90 NOISO LFSVPAGPPAQYSVTFHGQDSPLLPGDLVSLQHDAGPGALLRCPPAP---GHPGTQAPYF POEGU14_10_PE12 NOISO LFTVPAGPSSQYQVTFRKENIFVRAGDVFSIQHSAASGSFLRCRRRA----ASAGR---- PONPY16_3_PE15 ENSPPYG00000006987 LFSVPAGPPAQYSVTLHSQDVLVLPGDLVGLQHDAGPGALLRCSPAP---GHPGPQAPYL PONPY16_3_PE16 ISOFORMIN ------------------------------------------------------------ PROCAGS_6650_PE5 NOISO LLAVPAGPAAQYSIALRDQDTPLLPGDLLVLQHDAGPGALLQCPPAR---GSPGLEPPYL PTEVAGS_3466_PE5 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLQHD-DP-GALRCTPAF---DRP-PQDSYL RAT10_PE262 NOISO FFSVPAGPPTQYLVTLHGQDVPMLPGDLVALQHDAGPGTFLHCPLAS---SCPG-QALYL TETNG18_PE189 ENSTNIG00000014075 LFSLSAGPAAHVLLQDQLEDLLVSHGDVIALQHDAGPASLVRCQSSP----HSLWRQPVF TETNG18_PE190 ISOFORMIN LFSLSAGPAAHVLLQDQLEDLLVSHGDVIALQHDAGPASLVRCQSSP----HSLWRQPVF TURTRGS_3086_PE5 NOISO LFSVPAGPPAQYSVTFHDQGSPLLPGDLISLQHDAGPGALLRCPPAL---SVPGSEAPYF XENTR27_4_PE10 ISOFORMIN ------GNATNYLALFDDLRIQVSPNHLFVVQHDGPDGGFLYCYPNK---SGVRMFSLSQ XENTR27_4_PE11 ISOFORMIN ------GNATNYLALFDDLRIQVSPNHLFVVQHDGPDGGFLYCYPNK---SGVRMFSLSQ XENTR27_4_PE12 ISOFORMIN ------GNATNYLALFDDLRIQVSPNHLFVVQHDGPDGGFLYCYPNK---SGVRMFSLSQ XENTR27_4_PE8 ENSXETG00000015945 ------GNATNYLALFDDLRIQVSPNHLFVVQHDGPDGGFLYCYPNK---SGVRMFSLSQ XENTR27_4_PE9 ISOFORMIN ------------------------------------------------------------ MATCH CONSENSUS ??????G????????????????????????QHD????????C?????????????????

AILMEGL193445_1_PE11 NOISO --------AHLPVQLE--------------------------A--AP--AGPACALRLLA ANOCA1218_PE2 NOISO SWNSSAWEMDFHPSFH--------------------------ASKWH--NDSECEFRLLC BOVIN25_3_PE13 NOISO SANASAWLAHLPAQLE--------------------------A--AP--AGPACALRLLA CALJA12_3_PE50 ENSCJAG00000015073 SANASAWLPRLPAQLE--------------------------G--AR--ACPACALRLLV CANFA6_43_PE42 NOISO SATSPAWLVHLPAQLE--------------------------A--AP--AGPACALRLLV CAVPO4_23_PE41 NOISO STNASNWLAHLPTLLD--------------------------D--AR--PGPACILQLVT CHICK14_PE230 ENSGALG00000005714 STNSSDWALGLPASSI--------------------------GATWI--HNTVCSLRVLY CHICK14_PE231 ISOFORMIN STNSSDWALGLPASSI--------------------------GATWI--HNTVCSLRVLY DANRE1_57_PE22 NOISO IQNRSHWWDANETLQADV------------------------EGVWE--EGVLCQIRVLY DIPORGS_421_PE4 NOISO STNASVWLASLPAQVE--------------------------G--AQ--TGPACALQLRL ERIEUGS_1621_PE2 NOISO SANASGWLLHLPPQLE--------------------------A--AP--AGPSCALRVLT FELCAGS_5159_PE2 NOISO SAVASAWLAHLPAQLE--------------------------V--AP--TGPACALRLLA FUGRU189_PE62 ISOFORMIN ALNLSEWFGINNTPVPPDNLAGDGADPLPDPELDLKALVEGTRGSWL--ENAVCPIRVLY FUGRU189_PE63 ISOFORMIN ALNLSEWFGINNTPVPPDN-------------------------LAGDGADPLCPIRVLY FUGRU189_PE64 ENSTRUG00000008067 ALNLSEWFGINNTPVPPDS-------------------------SWL--ENAVCPIRVLY FUGRU189_PE65 ISOFORMIN ------------------------------------------------------------ GASACGROUPIX_16_PE21 ENSGACG00000018946 ALNQSEWFWINNTAQSIE------------------------SGVWL--EEVVCPVRVLY GORGO16_3_PE27 ENSGGOG00000007016 SANASSWLPHLPAQLE--------------------------G--TW--ACPACALRLLA HORSE13_41_PE34 ENSECAG00000006899 STNASAWLTRLPAQLE--------------------------V--AS--ASPACALRLFA HORSE13_41_PE35 ISOFORMIN STNASAWLTRLPAQLE--------------------------V--AS--ASPACALRLFA HS16_PE357 ENSG00000008710 SANASSWLPHLPAQLE--------------------------G--TW--ACPACALRLLA HS16_PE358 ISOFORMIN SANASSWLPHLPAQLE--------------------------G--TW--ACPACALRLLA HS16_PE359 ISOFORMIN ------------------------------------------------------------ HS16_PE360 ISOFORMIN SANASSWLPHLPAQLE--------------------------G--TW--ACPACALRLLA LOXAF53_15_PE1 NOISO LANASEWLTHLPTQLE--------------------------E--AP--VGPACALRLLG MACEUGS_650_PE4 NOISO SANVSTWLHRLPAHLG--------------------------C--TS--NGTTCALHLLF MICMUGS_282_PE3 NOISO FTNASAWLAHLPVQLE--------------------------G--AR--AGLPCALRVLT MONDO6_161_PE25 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE26 ENSMODG00000016034 SANASTWLPSLPAHFS--------------------------EVPVP--NGSTCALRLLF MONDO6_161_PE27 ISOFORMIN SANASTWLPSLPAHFS--------------------------EVPVP--NGSTCALRLLF MONDO6_161_PE28 ISOFORMIN SANASTWLPSLPAHFS--------------------------EVPVP--NGSTCALRLLF MOUSE17_PE457 NOISO STNASDWMTNLPVHLE--------------------------E--AW--AGPVCSLQLLL MYOLUGS_6259_PE4 NOISO STNASAWLGCLPTQLE--------------------------A--SR--AGQACALRLLT OCHPRGS_50_PE1 NOISO SSNSSAWLAHLPTKLQ--------------------------D--SP--AGRTCALWLLA ORYLA1073_PE1 NOISO ALNMSKWFWTNNTRQSAD----SSTNPLPDPELDLEALLQDGVGGWL--EEAVCSIRILY PIG3_37_PE90 NOISO STNASAWLARLPAQLE--------------------------A--AP--AGLTCALRLLA POEGU14_10_PE12 NOISO -GNCSAWAAGSCHSPA--------------------------GAPRA--NSSACSLRVRY PONPY16_3_PE15 ENSPPYG00000006987 SANASSWLPHLPAQLE--------------------------G--TR--ACPACALRLLA PONPY16_3_PE16 ISOFORMIN ------------------------------------------------------------ PROCAGS_6650_PE5 NOISO WAHASAWLARLPAQLE--------------------------E--AP--DGLACVLRLLG PTEVAGS_3466_PE5 NOISO STNASAWLACLPTQLE--------------------------A--GW--AGQACALQLLT RAT10_PE262 NOISO STNASDWMTNLPVHLE--------------------------E--AW--AGPVCSLQLLL TETNG18_PE189 ENSTNIG00000014075 ALNLSQFEG----------------PPPADPRLDVQASVEKGQGSWL--EDAVCPIRVLY TETNG18_PE190 ISOFORMIN ALNLSQFEG----------------PPPADPRLDVQASVEKGQGSWL--EDAVCPIRVLY TURTRGS_3086_PE5 NOISO STNVSAWLAHLPAKLE--------------------------A--AP--AGPACALRLLV XENTR27_4_PE10 ISOFORMIN WISCIPRRSGQMDSNF--------------------------C--SM--RLTGTSEVKAP XENTR27_4_PE11 ISOFORMIN WISCIPRRSGQMDSNF--------------------------C--SM--RLTGTSEVKAP XENTR27_4_PE12 ISOFORMIN WISCIPRRSGQMDSNF--------------------------C--SM--RLTGTSEVKAP XENTR27_4_PE8 ENSXETG00000015945 WISCIPRRSGQMDSNF--------------------------C--SM--RLTGTSEVKAP XENTR27_4_PE9 ISOFORMIN ------------------------------------------------------------ MATCH CONSENSUS ?????????????????????????????????????????????????????C??????

AILMEGL193445_1_PE11 NOISO ATERLTPLLGLRPNPGLRQPGRYEVRAMVGNSVSTHNLSCSFEVLSPVAGLRVAHPIPHD ANOCA1218_PE2 NOISO TTEETSPIIR-KQNFGIPSPGFYTLRATISNTVFATNVSCDFGVESPISGLRVVSPPEQG BOVIN25_3_PE13 NOISO ATERLTPLLGLGPNPGLRRPGRYEVRATVGNSVSRHNLTCIFDVLSPVAGLRAIYPAPQD CALJA12_3_PE50 ENSCJAG00000015073 ATEQFTVLLGLRPNPGLQLPGRYEVQAEVDNGVSRHSLSCSFNVVSPVAGLRVIAPAPHD CANFA6_43_PE42 NOISO ATERLTTLLGLRPNPGLRRPGRYEVRATVGNSVSTHNLSCSFDVLSPVAGLRVAHPIPHD CAVPO4_23_PE41 NOISO ATERLSPLLGLRSNPGLQHPGRYEVRATVGNNVSTYNLSCSFNVVSPVAGLRVIYPATLD CHICK14_PE230 ENSGALG00000005714 AKEQLVPIIS-PQNAGLAHPGLYTVRASVDNGIFSANLSCNFWVTSQVSGLRVVHPAPQG CHICK14_PE231 ISOFORMIN AKEQLVPIIS-PQNAGLAHPGLYTVRASVDNGIFSANLSCNFWVTSQVSGLRVVHPAPQG DANRE1_57_PE22 NOISO VGQNQTGLQGPFLRSGLPQVGDYSLEVTSNDEDFPVTASCPIQVIPPL-TPTVIHPTNHN DIPORGS_421_PE4 NOISO ATEQLTVLLGLTPNPGLQRPGRYKVQATVGNSVSSHNLSCGFSVVSPLTGLRVVHPALLD ERIEUGS_1621_PE2 NOISO ATECLTPLLG--RNPGLRQPGRYEVRATVGSSVSQHNLSCLFQVVSPVAGLQLLYPVPQD FELCAGS_5159_PE2 NOISO ATERLTPLLGLRPNPGLRRPGHYEVRATVGNSVSMHNLSCDFDVLSPVAGLCVTHPSPHD FUGRU189_PE62 ISOFORMIN VGQSETRLRGAELSAGLPQPGLYNLLVTSAKQSDLVSASCSLQVLPPL-DLTVLHPSPQN FUGRU189_PE63 ISOFORMIN VGQSETRLRGAELSAGLPQPGLYNLLVTSAKQSDLVSASCSLQVLPPL-DLTVLHPSPQN FUGRU189_PE64 ENSTRUG00000008067 VGQSETRLRGAELSAGLPQPGLYNLLVTSAKQSDLVSASCSLQVLPPL-DLTVLHPSPQN FUGRU189_PE65 ISOFORMIN ------------------------------------------------------------ GASACGROUPIX_16_PE21 ENSGACG00000018946 VGHSETQLLGVQLSDGLKQPGLYRLLVTSAEPSYPASASCPLRVVPPL-GLTILHPHPEN GORGO16_3_PE27 ENSGGOG00000007016 ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPHH HORSE13_41_PE34 ENSECAG00000006899 ATERLTPLLGLRPNPGLRRPGRYEVRAMVGNSVSRHNLSCSFDVLSPVVGLQVVHPIPHD HORSE13_41_PE35 ISOFORMIN ATERLTPLLGLRPNPGLRRPGRYEVRAMVGNSVSRHNLSCSFDVLSPVVGLQVVHPIPHD HS16_PE357 ENSG00000008710 ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRD HS16_PE358 ISOFORMIN ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRD HS16_PE359 ISOFORMIN ------------------------------------------------------------ HS16_PE360 ISOFORMIN ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRD LOXAF53_15_PE1 NOISO ATERLTPLLGLSPKPGLRHPGHYKVQATVSNGVSTHNLSCSFSVASPVAGLRVVHPAALD MACEUGS_650_PE4 NOISO ATEQVTPLLGQPSNPGLQHLGHYVVRASVDNGVSSHNLSCSFDVLSPVVGLRVIHPAPQS MICMUGS_282_PE3 NOISO ATERRTLLLGLKPNPGLQRPGRYEVRAVVGNSVSRHNLSCIFSVVSPVTGLRVIHPAPQD MONDO6_161_PE25 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE26 ENSMODG00000016034 ATEQVTRLLGQPSNPGLQHVGRYLFRASLDNGVSSHNLSCSFHVLSPVAGLRVIHPMPQG MONDO6_161_PE27 ISOFORMIN ATEQVTRLLGQPSNPGLQHVGRYLFRASLDNGVSSHNLSCSFHVLSPVAGLRVIHPMPQG MONDO6_161_PE28 ISOFORMIN ATEQVTRLLGQPSNPGLQHVGRYLFRASLDNGVSSHNLSCSFHVLSPVAGLRVIHPMPQG MOUSE17_PE457 NOISO VTERLTPLLGLGPNPGLQHPGHYEVRATVGNSVSRQNLSCSFSVVSPIAGLRVIHPIPLD MYOLUGS_6259_PE4 NOISO ATERLTPLLGLRPNPGLRQPGRYEVRASVGNNVSRWNLSCSFDVLSSVAGLRVVHPTPHD OCHPRGS_50_PE1 NOISO ATEQLTPLLGLTPNPGLPRPGRYKVQATVGNSVSRHNLSCSFDVVSPVTGLRVTYPATQD ORYLA1073_PE1 NOISO VGHSKTQLHGVQLSAGLPQPGLYSLLVSSTGASYPASASCLLQVLPPL-ALTVLHPPSQN PIG3_37_PE90 NOISO ATEQFTPLLGLSPNPGLQQPGRYEVRAMVGNGVSRHNLSCSFNVLSPVAGLRVIYPPPHD POEGU14_10_PE12 NOISO AEEQLVPVLS-PHNAGLERPGGYAVRASVGNGLFSANLSCGFRVASRVSGLRVLHPAPQG PONPY16_3_PE15 ENSPPYG00000006987 ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSGHNLSCTFEVVSAVAGLRVIYPTPRD PONPY16_3_PE16 ISOFORMIN ------------------------------------------------------------ PROCAGS_6650_PE5 NOISO AEEHLTPLLGPNPKPGLQRPGRYEVRAVVSNGVSTRNLSCSFAVVSPVVGLRVVHPASLN PTEVAGS_3466_PE5 NOISO ATERLTPLLG-RPNPGLQRPGHYEVRASVGNSVSRRNLSCSFDVLSPVAGLRVIYPIPHD RAT10_PE262 NOISO VTEQLTPLLGLGSNPGLQHPGHYEVRATVGNSISRQNLSCSFSVVSPVAGLRVIHPIPLD TETNG18_PE189 ENSTNIG00000014075 VGQNQTRLEGAQLAAGLPQPGLYSLQVTSSEPLNPASASCPLRVLPPL-GLKVLHPSPQN TETNG18_PE190 ISOFORMIN VGQNQTRLEGAQLAAGLPQPGLYSLQVTSSEPLNPASASCPLRVLPPL-GLKVLHPSPQN TURTRGS_3086_PE5 NOISO ATERLTPLLGLSPNPGLRRPGRYEVRATVGNSVSRHNLSCSFNVFSPVAGLRAIYPAPYD XENTR27_4_PE10 ISOFORMIN ILDPNPGLAWPGHYVVTAFFSNQEFKANRSCTFQVASPVSGLQAVYPVSQQDIIYLPSNN XENTR27_4_PE11 ISOFORMIN ILDPNPGLAWPGHYVVTAFFSNQEFKANRSCTFQVASPVSGLQAVYPVSQQDIIYLPSNN XENTR27_4_PE12 ISOFORMIN ILDPNPGLAWPGHYVVTAFFSNQEFKANRSCTFQVASPVSGLQAVYPVSQQDIIYLPSNN XENTR27_4_PE8 ENSXETG00000015945 ILDPNPGLAWPGHYVVTAFFSNQEFKANRSCTFQVASPVSGLQAVYPVSQQDIIYLPSNN XENTR27_4_PE9 ISOFORMIN ------------------------------------------------------------ MATCH CONSENSUS ???????L???????GL???G?Y???????????????SC???V??P???L????P????

AILMEGL193445_1_PE11 NOISO GRLYVPTNSSALVLRVDSGTNTTATARWPGGNV--SAPFEAACPAAVAALVPGCAL---- ANOCA1218_PE2 NOISO GILYVEANHTFLVVKISSGG-ANTTVGWIGGNR--STLFEKTCPVSV----VKCGP---- BOVIN25_3_PE13 NOISO GRLYVPTSGSPLVLQVDSGANATAEARWPGGNA--SAPFEAACPAAVAALAPGCAQ---- CALJA12_3_PE50 ENSCJAG00000015073 GRLYVPTNGSALVLQLDSGANATATARWAGGNV--SARFEATCPALVATLVPSCPW---- CANFA6_43_PE42 NOISO GRLYVPTNSSVLVLQVDSGTNATATARWPGGNA--SAPFEATCPATVAALVPSCTL---- CAVPO4_23_PE41 NOISO GQLYVPTSGSVLVLQVDSGANATATAYWPGGNV--SAPLETACPTMLDALKPICTQ---- CHICK14_PE230 ENSGALG00000005714 GKVYVPSDHITLVVKISSG--MNATARWLGDNH--TFPFEEACPLTIAPLTSDCAR---- CHICK14_PE231 ISOFORMIN GKVYVPSDHITLVVKISSG--MNATARWLGDNH--TFPFEEACPLTIAPLTSDCAR---- DANRE1_57_PE22 NOISO NTVYFLPNQTWVLIKVRSQHSAL--IGCQGNNL--TVAFERACPQSLLSKVAECRQSD-- DIPORGS_421_PE4 NOISO GHLYIPTNGSVLVLQVDSGASATATASWSGGHI--TAPFEAACPSVGATFQPDCTG---- ERIEUGS_1621_PE2 NOISO GHLYIPTHGSALVLQVDSGANVTATVHWPGGNV--SAPFEAKCPATVATWVPNCDL---- FELCAGS_5159_PE2 NOISO GLLYVPTNDSVLLLWVDSSINVTDTDHWAGGNV--CTPFEPAFPAPSCALVPRCAL---- FUGRU189_PE62 ISOFORMIN GTLFLESNRTRLLLRVQSRYETK--AFYRTSNS--SATFHPYCPQEFS--SRLCHPSTSE FUGRU189_PE63 ISOFORMIN GTLFLESNRTRLLLRVQSRYETK--AFYRTSNS--SATFHPYCPQEFS--SRLCHPSTSE FUGRU189_PE64 ENSTRUG00000008067 GTLFLESNRTRLLLRVQSRYETK--AFYRTSNS--SATFHPYCPQEFS--SRLCHPSTSE FUGRU189_PE65 ISOFORMIN ------------------------------------------------------------ GASACGROUPIX_16_PE21 ENSGACG00000018946 GTLYLQPSNTKLLLRVRSSYPTK--AWRPGGNH--SVTFQPECPQEFSAGPGLCQP---- GORGO16_3_PE27 ENSGGOG00000007016 GRLYVPTNGSALVLQVDSGANATATARWPGGSV--SARFENACPALVATFVPGCPW---- HORSE13_41_PE34 ENSECAG00000006899 GRLYVPTNGSALVLQADSGANATATARWPGGNV--SAPFEATCPPMVAALVPSCTR---- HORSE13_41_PE35 ISOFORMIN GRLYVPTNGSALVLQADSGANATATARWPGGNV--SAPFEATCPPMVAALVPSCTR---- HS16_PE357 ENSG00000008710 GRLYVPTNGSALVLQVDSGANATATARWPGGSV--SARFENVCPALVATFVPGCPW---- HS16_PE358 ISOFORMIN GRLYVPTNGSALVLQVDSGANATATARWPGGSV--SARFENVCPALVATFVPGCPW---- HS16_PE359 ISOFORMIN ------------------------------------------------------------ HS16_PE360 ISOFORMIN GRLYVPTNGSALVLQVDSGANATATARWPGGSV--SARFENVCPALVATFVPGCPW---- LOXAF53_15_PE1 NOISO GRLYVPTNRSALVLAVDAGANTTAMAHWRGGNA--SASFEPACPAVLDALAPGCPH---- MACEUGS_650_PE4 NOISO GRFYVSTNWTYLVLKISSGVNSTA--SRLGSNQ--SVPFEASCPPGVAQLTTDCIR---- MICMUGS_282_PE3 NOISO GHLYVPTNGSALVLQVDSGANAMATAHWPGGNV--SAPFEAACPATVATLVPGCHQ---- MONDO6_161_PE25 ISOFORMIN ------------------------------------------------------------ MONDO6_161_PE26 ENSMODG00000016034 GLFYVSTNWTYLVLKISSGANSTA--RRLGSNQ--SVPFEASCPLGVARLTADCAR---- MONDO6_161_PE27 ISOFORMIN GLFYVSTNWTYLVLKISSGANSTA--RRLGSNQ--SVPFEASCPLGVARLTADCAR---- MONDO6_161_PE28 ISOFORMIN GLFYVSTNWTYLVLKISSGANSTA--RRLGSNQ--SVPFEASCPLGVARLTADCAR---- MOUSE17_PE457 NOISO GHIYVPTNGSVLVLQVDSGANATATAQWFGGNI--SAPFEDACPPEVDFLKQDCTE---- MYOLUGS_6259_PE4 NOISO GLLYVSTNGSALVLQVDSGANATATVRWPGGNI--SAPFEATCPDSVADLVPSCAH---- OCHPRGS_50_PE1 NOISO GQLYIPTGGSVLLLQVDSGANATATARWTGGNV--SAPFMATCPAATAALVPACAQ---- ORYLA1073_PE1 NOISO GSIFLQPSSTRLLLRVQSRYATT--ASRRGSNH--SVRFQSECPSEFAF-TTLCQPVSSS PIG3_37_PE90 NOISO GRLYVPTNGSALVLQVDSGANATAMARWPGGNV--SAPFEATCPIMVAALVPGCDC---- POEGU14_10_PE12 NOISO SRLYLPTNHTALLLKLSSG--VNATASCLGDNR--TVPFVATCPPALA---ALCAR---- PONPY16_3_PE15 ENSPPYG00000006987 GRLYVPTNGSALVLQVDSGANATATARWPGGNV--SARFEAACPALVATFVPGCPW---- PONPY16_3_PE16 ISOFORMIN ------------------------------------------------------------ PROCAGS_6650_PE5 NOISO GQLYVPTNHSALVLAVDAGANTTAVAHWPGGNA--SAPFEAICPTVVDTLAPGCPH---- PTEVAGS_3466_PE5 NOISO GLFYMSTNGSTLVLQVDSGSNATATVRWPGDNI--SAPFEATCPDSVVALVPSCAS---- RAT10_PE262 NOISO GHIYVPTNGSILVLQVDSGANATATAHWFGGNV--SAPFEDACPPEVDFLKQDCTE---- TETNG18_PE189 ENSTNIG00000014075 GTLFLQPNITRLLLRVQSRYETT--AFHRGSSLPAGVPFRPDCPQEFP--PRLCHPGTSP TETNG18_PE190 ISOFORMIN GTLFLQPNITRLLLRVQSRYETT--AFHRGSSLPAGVPFRPDCPQEFP--PRLCHPGTSP TURTRGS_3086_PE5 NOISO GRLYMPTNGSALVLQVDSGTNATATARWPGGNV--SAPFEAACPATVAALVPGCAH---- XENTR27_4_PE10 ISOFORMIN TVLVLKILSGSNATASWSGSNESWSFQPTCPPS--IAAFTDVCT-----------E---- XENTR27_4_PE11 ISOFORMIN TVLVLKILSGSNATASWSGSNESWSFQPTCPPS--IAAFTDVCT-----------E---- XENTR27_4_PE12 ISOFORMIN TVLVLKILSGSNATASWSGSNESWSFQPTCPPS--IAAFTDVCT-----------E---- XENTR27_4_PE8 ENSXETG00000015945 TVLVLKILSGSNATASWSGSNESWSFQPTCPPS--IAAFTDVCT-----------E---- XENTR27_4_PE9 ISOFORMIN --------------------------------------FTDVCT-----------E---- MATCH CONSENSUS ???????????L?????S????????????????????F???CP?????????C??????

AILMEGL193445_1_PE11 NOISO -----EANTTLFSVLVLP---GLSEGEHAVEVVVEN-SAGRANLSLRVKAEEPICGLRAT ANOCA1218_PE2 NOISO -----KTDDTWFAVVSLE---GIVENGTTVVLQAEN-TVSTQNLTVVVKAEEGIRGLRAT BOVIN25_3_PE13 NOISO -----EANGSLFSMLTLP---GLREGEHEVEVVVEN-GAGRANLSLLVTAEEPIRGLRAT CALJA12_3_PE50 ENSCJAG00000015073 -----ETNDTLFSVIALP---WLSEGEHVLEVVAEN-SASRANLSLQVMAEEPICGLRAM CANFA6_43_PE42 NOISO -----EANDTLFAVLVLP---GLSEGEHAVEIMVEN-SAGHANLSLRVKAEEPICGLRAA CAVPO4_23_PE41 NOISO -----ETNNTLFSVLVLP---GLSQGEHAVDVVVQN-SAGRANLTLRVMAEEPIRGLHAT CHICK14_PE230 ENSGALG00000005714 -----ENNDTWFAVLSLS---GLKEGASTHTLVAEN-AISSQNITITIKVEQPIRGLRAT CHICK14_PE231 ISOFORMIN -----ENNDTWFAVLSLS---GLKEGASTHTLVAEN-AISSQNITITIKVEQPIRGLRAT DANRE1_57_PE22 NOISO -----PFNDTMFAWVDL--QAGSTPGQTTVVLHVKS-EVTEAYLQIQARVQEPLRGLLIQ DIPORGS_421_PE4 NOISO -----EANHTWFSVLALP---RLSEGEHAVEIVAQN-RDSRANLSLRVTAEEPIRGLRAV ERIEUGS_1621_PE2 NOISO -----KANSTLFSVLALP---GLSEGEHTVDVAVENDGGGRADLSLWLRAEEPICGLRAT FELCAGS_5159_PE2 NOISO -----EANTTLFAMLARI---SLREGDHWMKVXXXX-XXXXXXXXXXXXXXXXXXXXXXX FUGRU189_PE62 ISOFORMIN GSGAEVAEPSMYAVLDLNLKIKEHTGPVQVELMAHN-NVTEASLTVLVQLEESLRGLVVQ FUGRU189_PE63 ISOFORMIN GSGAEVAEPSM---------IKEHTGPVQVELMAHN-NVTEASLTVLVQLEESLRGLVVQ FUGRU189_PE64 ENSTRUG00000008067 GSGAEVAEPSMYAVLDLNLKIKEHTGPVQVELMAHN-NVTEASLTVLVQLEESLRGLVVQ FUGRU189_PE65 ISOFORMIN ------------------------------ELMAHN-NVTEASLTVLVQLEESLRGLVVQ GASACGROUPIX_16_PE21 ENSGACG00000018946 -----EAGSDLYAVLDLNLSTEEQRSPVKVELEAHN-NVTEASLSVVVHLEEPLRVLVVQ GORGO16_3_PE27 ENSGGOG00000007016 -----ETNDTLFSAVALP---WLSEGEHVMDVVVEN-SASRANLSLRVTAEEPICGLRAT HORSE13_41_PE34 ENSECAG00000006899 -----EANDTLFSVLVLP---RLSEGEHAVEVVVEN-SAGQVSLRLQVKAEEPICGLRAT HORSE13_41_PE35 ISOFORMIN -----EANDTLFSVLVLP---RLSEGEHAVEVVVEN-SAGQVSLRLQVKAEEPICGLRAT HS16_PE357 ENSG00000008710 -----ETNDTLFSVVALP---WLSEGEHVVDVVVEN-SASRANLSLRVTAEEPICGLRAT HS16_PE358 ISOFORMIN -----ETNDTLFSVVALP---WLSEGEHVVDVVVEN-SASRANLSLRVTAEEPICGLRAT HS16_PE359 ISOFORMIN ------------------------EGEHVVDVVVEN-SASRANLSLRVTAEEPICGLRAT HS16_PE360 ISOFORMIN -----ETNDTLFSVVALP---WLSEGEHVVDVVVEN-SASRANLSLRVTAEEPICGLRAT LOXAF53_15_PE1 NOISO -----EANSMLFSVLVLP---GLCEGEHIVEVVAEN-SVSQARLSLRVMAEEPVRGLRAT MACEUGS_650_PE4 NOISO -----ETNDTWFALFELD---GLGDDESLVEIVAEN-HVSRENISIQVKAEEPIRGLSAT MICMUGS_282_PE3 NOISO -----ETNDTLFSVLALP---GLSEGEHSVEVVAEN-SASRANLSLQVTAEEPICGLRAM MONDO6_161_PE25 ISOFORMIN ----------------------------LVEIVAEN-RVSLENISIQVKAEEPIRGLSAT MONDO6_161_PE26 ENSMODG00000016034 -----ETNDSWFALLELD---GLGEDESLVEIVAEN-RVSLENISIQVKAEEPIRGLSAT MONDO6_161_PE27 ISOFORMIN -----ETNDSWFALLELD---GLGEDESLVEIVAEN-RVSLENISIQVKAEEPIRGLSAT MONDO6_161_PE28 ISOFORMIN -----ETNDSWFALLELD---GLGEDESLVEIVAEN-RVSLENISIQVKAEEPIRGLSAT MOUSE17_PE457 NOISO -----EANGTLFSVLMLP---RLKEGDHTVEIVAQN-GASQANLSLRVTAEEPICGLRAV MYOLUGS_6259_PE4 NOISO -----EANNTLFSVLALP---RLHEGEYAVEVVVEN-SASRANLSLWVKVEEPICGLRAM OCHPRGS_50_PE1 NOISO -----ETSDTLFAVLVLP---ALREGEHTVEVVAEN-SASHANLSLRVTAEEPIRGLHAS ORYLA1073_PE1 NOISO ESGLPGSDPSLFAVLDLNLAAEEQKGSVQVELLAHS-EVTEASLVVLIQLEVPLQGLQVE PIG3_37_PE90 NOISO -----EVNATLFSVLVLP---RLNEGEHEVDVVVEN-GAGRANLSLQVKAEEPIRGLRAT POEGU14_10_PE12 NOISO -----ETNDTWFAVLQLG---GLGQGLSTHVLVAEN-SVSSQNITVTVKVEEPIRGLRAT PONPY16_3_PE15 ENSPPYG00000006987 -----ETNDTLFSVVALP---WLSEGEHVVDVVVEN-SASQANLSLRVTAEEPICGLRAT PONPY16_3_PE16 ISOFORMIN ------------------------EGEHVVDVVVEN-SASQANLSLRVTAEEPICGLRAT PROCAGS_6650_PE5 NOISO -----AANGTLFSVLVLP---GLSEGEHVVEVVATN-GISQACLSLRVTAEEPVRGLRAM PTEVAGS_3466_PE5 NOISO -----EANDTLFSVLALP---RLSEGKHSVEVVVEN-SAGQANLSLWVKAEEPICGLRAT RAT10_PE262 NOISO -----EANGTLFSVLVLP---RLKEGDHTVEIVAQN-GASQANLSLRVTAEEPICGLRAV TETNG18_PE189 ENSTNIG00000014075 GSAVDAPEPSLYAALDLNLKMGEHAGPVQVELQARN-NVTEASLTVFVQVEEPLRGLVVK TETNG18_PE190 ISOFORMIN GSAVDAPEPSLYAALDLNLKMGEHAGPVQVELQARN-NVTEASLTVFVQVEEPLRGLVVK TURTRGS_3086_PE5 NOISO -----EANSTLFSVLALP---GLSEGEHDVEVVVEN-GAGRANLSLRVKAEEPIRGLRAT XENTR27_4_PE10 ISOFORMIN -----GEDVW-YSEINLD---GRGKNFLDVVIIAQN-MINSQNLNVSVKIEEPIRGLSAS XENTR27_4_PE11 ISOFORMIN -----GEDVW-YSEINLD---GRGKNFLDVVIIAQN-MINSQNLNVSVKIEEPIRGLSAS XENTR27_4_PE12 ISOFORMIN -----GEDVW-YSEINLD---GRGKNFLDVVIIAQN-MINSQNLNVSVKIEEPIRGLSAS XENTR27_4_PE8 ENSXETG00000015945 -----GEDVW-YSEINLD---GRGKNFLDVVIIAQN-MINSQNLNVSVKIEEPIRGLSAS XENTR27_4_PE9 ISOFORMIN -----GE---------------------DVVIIAQN-MINSQNLNVSVKIEEPIRGLSAS MATCH : CONSENSUS ????????????????L????????????V?????N???????L???V??EEP??GL?A?

AILMEGL193445_1_PE11 NOISO PSPEARVLQGVLVRYSP-----VVDAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFK ANOCA1218_PE2 NOISO PDPESRILLNSRVTYVP-----RMDAGSEVTFRWTVDDKPSFTFYNEVFHVIYQVPAIYK BOVIN25_3_PE13 NOISO PSPEARVLQGVLVRYSP-----AVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFK CALJA12_3_PE50 ENSCJAG00000015073 PSPEARVLQGVLVRYSP-----VVDAGSDVVFRWTINDKQSLTFQNIVFNVIYQSSAVFK CANFA6_43_PE42 NOISO PSPEARVLQGVLVRYSP-----VVEAGSDVVFRWTIDDKQSLTFPHVVFNVIYQSAAVFS CAVPO4_23_PE41 NOISO PVPEARVLQGALVRYSP-----MVEAGSNVVFRWTIDDKQSLTFHNVVFNVIYQSAAIFK CHICK14_PE230 ENSGALG00000005714 PDPESRVLLNTRVSYVP-----VMEAGSDVTFRWTVDDKPSFTFYNVVFNVIYQSPAVYK CHICK14_PE231 ISOFORMIN PDPESRVLLNTRVSYVP-----VMEAGSDVTFRWTVDDKPSFTFYNVVFNVIYQSPAVYK DANRE1_57_PE22 NOISO PHPAHRVLMESVVCYTP-----SVEAGTDPSFRWTVDDKPHFTYYNSMLNIIYQNAAVYK DIPORGS_421_PE4 NOISO PSPEARVLQGVLVRYSP-----MVESGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAIFK ERIEUGS_1621_PE2 NOISO PSPEARVLQGVLVRYSP-----VVEAGSGVVFRWTIDDKQSLTFHNVAFNVIYQSAAVFK FELCAGS_5159_PE2 NOISO XXXXXXXXXXXXXRYSP-----MVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFK FUGRU189_PE62 ISOFORMIN PHPARRVLMESVVSYTA-----SVLEGSNPTFKWTVDDKPFFTYYNTVLNVIYQHADVYK FUGRU189_PE63 ISOFORMIN PHPARRVLMESVVSYTA-----SVLEGSNPTFKWTVDDKPFFTYYNTVLNVIYQHADVYK FUGRU189_PE64 ENSTRUG00000008067 PHPARRVLMESVVSYTA-----SVLEGSNPTFKWTVDDKPFFTYYNTVLNVIYQHADVYK FUGRU189_PE65 ISOFORMIN PHPARRVLMESVVSYTA-----SVLEGSNPTFKWTVDDKPFFTYYNTVLNVIYQHADVYK GASACGROUPIX_16_PE21 ENSGACG00000018946 PHPAHRVLMESVVVYTA-----SVQEGSNPTFKWTVDDKPYFTYYNTVLNVIYQQAATYK GORGO16_3_PE27 ENSGGOG00000007016 PSPEARVLQGVLVRYSP-----VVEAGSDMVFRWTINDKQSLTFQNVVFNVI-QSAAVFK HORSE13_41_PE34 ENSECAG00000006899 PSPEARVLQGVLVRYSP-----LVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAIFK HORSE13_41_PE35 ISOFORMIN PSPEARVLQGVLVRYSP-----LVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAIFK HS16_PE357 ENSG00000008710 PSPEARVLQGVLVRYSP-----VVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFK HS16_PE358 ISOFORMIN PSPEARVLQGVLVRYSP-----VVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFK HS16_PE359 ISOFORMIN PSPEARVLQGVLVRYSP-----VVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFK HS16_PE360 ISOFORMIN PSPEARVLQGVLVRYSP-----VVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFK LOXAF53_15_PE1 NOISO PSPESRVLQGVLVRYSP-----SVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAIFK MACEUGS_650_PE4 NOISO PNPQTRVLQSTLVRYSP-----VVDAGSDVVFKWTIDDKQSLTFYNIVFNVIYQSAAVFK MICMUGS_282_PE3 NOISO PSPEARVLQGVLVRYSP-----AVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFK MONDO6_161_PE25 ISOFORMIN PNPQTRVLQSTLVRYSP-----VVEAGSDVVFKWTIDDKQSLTFYNVVFNVIYQSAAVFK MONDO6_161_PE26 ENSMODG00000016034 PNPQTRVLQSTLVRYSP-----VVEAGSDVVFKWTIDDKQSLTFYNVVFNVIYQSAAVFK MONDO6_161_PE27 ISOFORMIN PNPQTRVLQSTLVRYSP-----VVEAGSDVVFKWTIDDKQSLTFYNVVFNVIYQSAAVFK MONDO6_161_PE28 ISOFORMIN PNPQTRVLQSTLVRYSP-----VVEAGSDVVFKWTIDDKQSLTFYNVVFNVIYQSAAVFK MOUSE17_PE457 NOISO PSPEARVLQGILVRYSP-----MVEAGSDVAFRWTIDDKQSLTFHNTVFNVIYQSAAIFK MYOLUGS_6259_PE4 NOISO PSPEARVLQGVLVRYSP-----VVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFK OCHPRGS_50_PE1 NOISO PSPENRVLQGVLVRYSP-----VVEAGSDVTFRWTIDDKQSLTFHNMVFNVIYQSAAIFK ORYLA1073_PE1 NOISO PPPVHRVLMESVVSYTA-----SVTEGSNPTFKWTVDDKPYFTYYNSVLNVIYQHAATYK PIG3_37_PE90 NOISO PSPEARVLQGVLVRYSP-----AVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAIFK POEGU14_10_PE12 NOISO PDPESRVLLNTRVSYIP-----VMEAGSDVTFRWTVDDKPSFTFYNVVFNVIYQSPAVYK PONPY16_3_PE15 ENSPPYG00000006987 PSPEARVLQGVLVRYSP-----VVEAGSDMVFRWTINDKPSLTFQNVVFNVIYQSAAVFK PONPY16_3_PE16 ISOFORMIN PSPEARVLQGVLVRYSP-----VVEAGSDMVFRWTINDKPSLTFQNVVFNVIYQSAAVFK PROCAGS_6650_PE5 NOISO PSPESRVLQGMLVXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX PTEVAGS_3466_PE5 NOISO PSPEARVLQGVLVRYSP-----MVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAIFK RAT10_PE262 NOISO PSPEARVLQGILVRYSP-----MVEAGSDVAFRWTIDDKQSLTFHNTVFNVIYQTAAVFK TETNG18_PE189 ENSTNIG00000014075 PHPAQRVLMELLVSYTA-----SVSEGSNPTFKWTVDDKPFFTYYNTVLNVIYQHAAVYK TETNG18_PE190 ISOFORMIN PHPAQRVLMELLVSYTA-----SVSEGSNPTFKWTVDDKPFFTYYNTVLNVIYQHAAVYK TURTRGS_3086_PE5 NOISO PSPEARVLQGVLVRYSP-----VVEAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFK XENTR27_4_PE10 ISOFORMIN PFPQTRVLVN-----TKVINVASVEAGTNVSFKWTVDDKPSFTYHNVVFNVIYQSAAVYK XENTR27_4_PE11 ISOFORMIN PFPQTRVLVN-----TKVINVASVEAGTNVSFKWTVDDKPSFTYHNVVFNVIYQSAAVYK XENTR27_4_PE12 ISOFORMIN PFPQTRVLEGMMSLSHPVINVASVEAGTNVSFKWTVDDKPSFTYHNVVFNVIYQSAAVYK XENTR27_4_PE8 ENSXETG00000015945 PFPQTRVLEGMMSLSHPVINVASVEAGTNVSFKWTVDDKPSFTYHNVVFNVIYQSAAVYK XENTR27_4_PE9 ISOFORMIN PFPQTRVLEGMMSLSHPVINVASVEAGTNVSFKWTVDDKPSFTYHNVVFNVIYQSAAVYK MATCH CONSENSUS P?P??RVL????V?Y????????V?AGS???F?WT?DDK?S?T??N?VFNVIYQ?AA??K

AILMEGL193445_1_PE11 NOISO LSLTASNHVSNVTVNYNVTVERMHRMRGLWVSAVPPVLPPNASLALAAHVLVDSAVEVAF ANOCA1218_PE2 NOISO LSLTASNHVSNVTVDYNITVEKMNRMKDLLVSEVPQRAPQNGTLDLAASVRVDSAVKATF BOVIN25_3_PE13 NOISO LSLTASNHVSSVSAHFNVTVEPMQRMRGLCVSAVPPVLAPNATLALAAHVLVDSAVEVAF CALJA12_3_PE50 ENSCJAG00000015073 LSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPDASLLLTAGVLVDSAVEVAF CANFA6_43_PE42 NOISO SRLTASNHVSNVTVNYNVTVERMHKMKGLRVSAVPPVLPPNTTLELAAHVLVDSAVEVAF CAVPO4_23_PE41 NOISO LSLTASNHVSNVTVNYNVTVERMNKMRSLQVSAVPAVLASNTMLALMASVMVDSAVEVAF CHICK14_PE230 ENSGALG00000005714 LSLTASNHVSNFTVNYNVTVEMMNKMKNLTVLGIPPVLPQNSTVEFTARVQVDSAVDAMF CHICK14_PE231 ISOFORMIN LSLTASNHVSNFTVNYNVTVEMMNKMKNLTVLGIPPVLPQNSTVEFTARVQVDSAVDAMF DANRE1_57_PE22 NOISO LTVTAMNQVSMLTEDFNVTVDRMNPMTDPTVHGVPKIVQQGSLLNLTAFITIDTAVDVTF DIPORGS_421_PE4 NOISO LSLTASNHVSNVTVNYNVSVERMNRMRGLRVSAVPAVLPLNATLELMASVLVDAAVEVAF ERIEUGS_1621_PE2 NOISO LSLTASNHVSNVTVNYNVTVERMQHMRDLRVSAVPTVLPPNGTLVLAASVLVDSAVEAAF FELCAGS_5159_PE2 NOISO LSLTASNHVSNVTVNYNVTVERMNRMRGLWVSAVPPVLPPNATLALAAHVLVDSAVEVAF FUGRU189_PE62 ISOFORMIN LTVTAMNHVSTLTEDFNVTVDRLQPMTNLTVKGVPDVVPQGSTQTLTTSVLIDMAVPATV FUGRU189_PE63 ISOFORMIN LTVTAMNHVSTLTEDFNVTVDRLQPMTNLTVKGVPDVVPQGSTQTLTTSVLIDMAVPATV FUGRU189_PE64 ENSTRUG00000008067 LTVTAMNHVSTLTEDFNVTVDRLQPMTNLTVKGVPDVVPQGSTQTLTTSVLIDMAVPATV FUGRU189_PE65 ISOFORMIN LTVTAMNHVSTLTEDFNVTVDRLQPMTNLTVKGVPDVVPQGSTQTLTTSVLIDMAVPATV GASACGROUPIX_16_PE21 ENSGACG00000018946 LTVTAMNHFSKLTEHFNVTVDRLQPMANVTVKGVPDVVPQCSTQTLTTSVLVDMSVAATF GORGO16_3_PE27 ENSGGOG00000007016 LSLTASNHVSNVTVNYNVTVERMNRMQGLRVSTVPAVLSPNATLALTAGVLVDSAVEVAF HORSE13_41_PE34 ENSECAG00000006899 LSLTASNHVSNVTVNYNVTVERMHRMRGLRVSAVPPVLPPNTTLVLAADVLVDSAVEVAF HORSE13_41_PE35 ISOFORMIN LSLTASNHVSNVTVNYNVTVERMHRMRGLRVSAVPPVLPPNTTLVLAADVLVDSAVEVAF HS16_PE357 ENSG00000008710 LSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAF HS16_PE358 ISOFORMIN LSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAF HS16_PE359 ISOFORMIN LSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAF HS16_PE360 ISOFORMIN LSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAF LOXAF53_15_PE1 NOISO LSLTASNHVSNVTVNYNVTVDRMNRMRGLRVSAVPAVLPQNATLALTAGVLVDSAVEVAF MACEUGS_650_PE4 NOISO LSLTASNHVSNVTVNYNVTVEKMNKMRDLVVSEVPAVIPQNTTLQLGASVQVDSAVEVAF MICMUGS_282_PE3 NOISO LSLTASNHVSNVTVNYNVSVERMNRMRGLQVSAVPAVLSPNATLALTASVLVDTAVEVAF MONDO6_161_PE25 ISOFORMIN LSLTASNHVSNVTVNYNVTVEKMNKMRDLVVSEVPAIIPQNTTLQLGASVQVDSAVEVTF MONDO6_161_PE26 ENSMODG00000016034 LSLTASNHVSNVTVNYNVTVEKMNKMRDLVVSEVPAIIPQNTTLQLGASVQVDSAVEVTF MONDO6_161_PE27 ISOFORMIN LSLTASNHVSNVTVNYNVTVEKMNKMRDLVVSEVPAIIPQNTTLQLGASVQVDSAVEVTF MONDO6_161_PE28 ISOFORMIN LSLTASNHVSNVTVNYNVTVEKMNKMRDLVVSEVPAIIPQNTTLQLGASVQVDSAVEVTF MOUSE17_PE457 NOISO LSLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPTVLPPNATLALTGGVLVDSAVEVAF MYOLUGS_6259_PE4 NOISO LSLTATNHVSNVTVNYNVTVERMHKMRGLRVSAVPPVLPPNATLELAADVLVDSAVEVAF OCHPRGS_50_PE1 NOISO LSLTASNHVSNATVDYNVTVERMNRMCGLQVSAVPAVLSPNTTLELTASVLVDSAMDVTF ORYLA1073_PE1 NOISO LTVTASNHVSTLTEHFNVTVDRLQPMADLTVSGVPDVVPQGSNQTLTTSVLVDMTVAATF PIG3_37_PE90 NOISO LSLTASNHVSNVTVNYNVTVERMHKMRGLRVSAVPPVLPLNATLALAAEVLVDSAVEVVF POEGU14_10_PE12 NOISO LSLTASNHVSNFTVNYNVTVEMMNRMRNLSVVGALPVVPQNSSVEFSARVHVDSAVEALF PONPY16_3_PE15 ENSPPYG00000006987 LSLTASNHVSNVTVNYNVTVERMNRMQGLRVSTVPAVLCPNATLALTAGVLVDSAVEVAF PONPY16_3_PE16 ISOFORMIN LSLTASNHVSNVTVNYNVTVERMNRMQGLRVSTVPAVLCPNATLALTAGVLVDSAVEVAF PROCAGS_6650_PE5 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVSEVPAVLPQNTTLLLTAAVLVDSAVEVAF PTEVAGS_3466_PE5 NOISO LSLTATNHVSNVTVNYNVTVERMHRMRGLQVSAVPPVLPPNATLAVAATVLVDSAVEVAF RAT10_PE262 NOISO LSLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPAVLPPNATLALTGGVLVDSAVEVAF TETNG18_PE189 ENSTNIG00000014075 LTVTATNHVSVLTEDFSVTVEQLRPMRNLSVKGVPDVVPQGSSQTLTTSVLIDMSVPATV TETNG18_PE190 ISOFORMIN LTVTATNHVSVLTEDFSVTVEQLRPMRNLSVKGVPDVVPQGSSQTLTTSVLIDMSVPATV TURTRGS_3086_PE5 NOISO LSLTASNHVSNVTVNYNVTVERMHRMRGLRVSAVPPVLPPNATLALAADVLVDSAMEVAF XENTR27_4_PE10 ISOFORMIN LTLSASNHVSNASVNYNVTVEKMNPMKDLMVFGVPLIATQNALLELSAIILVDSAVDATF XENTR27_4_PE11 ISOFORMIN LTLSASNHVSNASVNYNVTVEKMNPMKDLMVFGVPLIATQNALLELSAIILVDSAVDATF XENTR27_4_PE12 ISOFORMIN LTLSASNHVSNASVNYNVTVEKMNPMKDLMVFGVPLIATQNALLELSAIILVDSAVDATF XENTR27_4_PE8 ENSXETG00000015945 LTLSASNHVSNASVNYNVTVEKMNPMKDLMVFGVPLIATQNALLELSAIILVDSAVDATF XENTR27_4_PE9 ISOFORMIN LTLSASNHVSNASVNYNVTVEKMNPMKDLMVFGVPLIATQNALLELSAIILVDSAVDATF MATCH * . : :* :: . . CONSENSUS L?LTA?NHVS??T???NVTVE?M??M??L?V??VP?????N????L?A?V?VD?AV???F

AILMEGL193445_1_PE11 NOISO LWTFGDGNQVIGQFKPPYNESFQVPDPTVAQVLVGHNATHTYSI---PGDYNLTLLVSNA ANOCA1218_PE2 NOISO LWDFGDGNNASSQFQPPYNDSFLVPDPTIHQVVIAHNVSHAYQE---PGEYTLTVVVYNE BOVIN25_3_PE13 NOISO LWTFGDGQQAVGQFKPPYD-SFEVPDPTVAQVLVEHNTSHTYTF---PGEYSLSLLVSTA CALJA12_3_PE50 ENSCJAG00000015073 LWTFGDGEQALGHFQPPYDESFPVPDPSVAQVLVEHNVTHTYTA---PGEYILTVLASNA CANFA6_43_PE42 NOISO LWTFGDGDQVLGQFKPPYNESW-VPDPTVAQVLVEHSVTHVYAV---PGEYNLTLLVSNA CAVPO4_23_PE41 NOISO LWTFGDGQQVLGQFKPPYNKSFQVPDPTVAQVLVEHNVTHTYTN---AGEYNLTVLVSNA CHICK14_PE230 ENSGALG00000005714 LWDFGDGIQETYQFTPPYNKSFLVPDPSVHEVIIEHNVSHVYEY---PGDYILVVQVSNQ CHICK14_PE231 ISOFORMIN LWDFGDGIQETYQFTPPYNKSFLVPDPSVHEVIIEHNVSHVYEY---PGDYILVVQVSNQ DANRE1_57_PE22 NOISO WWWFGDGGNRTHQFKSPYDDN----P-STNMVGIRDHVEYIYAQ---PGEYTLLLSTSNR DIPORGS_421_PE4 NOISO LWTFGDGEQVVGQFKPPYGEAFQVPDPTVAQVLVEHNATHTYAS---PGEYNLTVLASNT ERIEUGS_1621_PE2 NOISO LWTFGDGEQMLDQFKPHYE-SFLVPNPKVAQVLVEHNTTHIYAF---PGEYNLTLLVSNA FELCAGS_5159_PE2 NOISO LWTFGDGDQVIGQFKPPYSESFRVPDPAVAQVLVEHNVTHAYAI---PGEYNLTLLVSNA FUGRU189_PE62 ISOFORMIN RWSFGDGGYEQFEHKPPYPSSLTCPE-SPYQVLLSSNVTYIYSQ---PGIYTAVVSVSNR FUGRU189_PE63 ISOFORMIN RWSFGDGGYEQFEHKPPYPSSLTCPE-SPYQVLLSSNVTYIYSQ---PGIYTAVVSVSNR FUGRU189_PE64 ENSTRUG00000008067 RWSFGDGGYEQFEHKPPYPSSLTCPE-SPYQVLLSSNVTYIYSQ---PGIYTAVVSVSNR FUGRU189_PE65 ISOFORMIN RWSFGDGGYEQFEHKPPYPSSLTCPE-SPYQVLLSSNVTYIYSQ---PGIYTAVVSVSNR GASACGROUPIX_16_PE21 ENSGACG00000018946 RWSFGDGGYKEFEYKPPYAPSLLCPD-SPNQVLLSNNVTYIYSQ---PGIYTALVSVSNR GORGO16_3_PE27 ENSGGOG00000007016 LWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVTHTYAA---PGEYILTVLASNA HORSE13_41_PE34 ENSECAG00000006899 LWTFGDGEQVIGQFKPPYNDSFRVPDPTVAQVLVEHNTTHTYAV---PGEYNLTLLVSNA HORSE13_41_PE35 ISOFORMIN LWTFGDGEQVIGQFKPPYNDSFRVPDPTVAQVLVEHNTTHTYAV---PGEYNLTLLVSNA HS16_PE357 ENSG00000008710 LWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAA---PGEYLLTVLASNA HS16_PE358 ISOFORMIN LWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAA---PGEYLLTVLASNA HS16_PE359 ISOFORMIN LWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAA---PGEYLLTVLASNA HS16_PE360 ISOFORMIN LWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAA---PGEYLLTVLASNA LOXAF53_15_PE1 NOISO LWTFGDGEQALGQFKPPYNESFPVLEPTVAQVLVEHNATHTYAT---PGDYNLTLLVSNA MACEUGS_650_PE4 NOISO LWTFGDGEQESGHFKPPYNESFLVPE--VSQVLIEHNVTHTYHV---PGDYNLTVFVFNT MICMUGS_282_PE3 NOISO LWTFGDE-QTLGQFKPXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXEYNLAVLAYNA MONDO6_161_PE25 ISOFORMIN LWTFGDGEQESGQFKPPYNESFLVPEPGVHQVLIEHNVTHTYHV---PGDYNITVFVYNT MONDO6_161_PE26 ENSMODG00000016034 LWTFGDGEQESGQFKPPYNESFLVPEPGVHQVLIEHNVTHTYHV---PGDYNITVFVYNT MONDO6_161_PE27 ISOFORMIN LWTFGDGEQESGQFKPPYNESFLVPEPGVHQVLIEHNVTHTYHV---PGDYNITVFVYNT MONDO6_161_PE28 ISOFORMIN LWTFGDGEQESGQFKPPYNESFLVPEPGVHQVLIEHNVTHTYHV---PGDYNITVFVYNT MOUSE17_PE457 NOISO LWNFGDGEQVLRQFKPPYDESFQVPDPTVAQVLVEHNTTHIYTT---PGEYNLTVLVSNT MYOLUGS_6259_PE4 NOISO LWTFGDGEQVIGQFKPPYDESFQVPDPMVAQVLVEHNTTHTYTI---PGEYNLTLLVSTA OCHPRGS_50_PE1 NOISO -HTFGDGQQVAGQFKPPYDEFFPDPDPTVAQVLVQHSTTHVYTS---PGEYNLTVLVSNT ORYLA1073_PE1 NOISO RWSYGDGGYEEFEFEPPYPPSLLCPD-SPNQVLLSKNITYIYSQ---PGIYTAQVSVSNR PIG3_37_PE90 NOISO LWTFGDGEQVIGQFKPPYNESFQVPDPTVAQVLVEHNVTHTYTD---PGEYNLTLLVSNA POEGU14_10_PE12 NOISO LWDFGDGVQETYLFKPPYNKSFLVPDPSVHEVVIEHNVSHIYQD---PGEYALMVVVSNQ PONPY16_3_PE15 ENSPPYG00000006987 LWTFGDGEQALHQFQPPYNKSFPVPDPSVAQVLVEHNVTHTYAA---PGEYILTVLASNA PONPY16_3_PE16 ISOFORMIN LWTFGDGEQALHQFQPPYNKSFPVPDPSVAQVLVEHNVTHTYAA---PGEYILTVLASNA PROCAGS_6650_PE5 NOISO LWTFGDGEQVLGQFKPPYNESFPVPEPAVAVVLVEHRATHTYVI---PGDYNLTLLVSSA PTEVAGS_3466_PE5 NOISO LWTFGDGEQVIGQFKPPYDESFQVPDPMVAQVLVEHNTTHTYTV---PGEYNLTLLVSNT RAT10_PE262 NOISO LWNFGDGEQVLRQFKPPYDESFQVPDPTVAQVLVEHNTTHIYNT---PGEYNLTVTVSNT TETNG18_PE189 ENSTNIG00000014075 RWSFGDGGYEQFEYQPPYPASLLCPE-SPSQVLLSNNVTYVYSQ---PGIYVAVVSVSNR TETNG18_PE190 ISOFORMIN RWSFGDGGYEQFEYQPPYPASLLCPE-SPSQVLLSNNVTYVYSQ---PGIYVAVVSVSNR TURTRGS_3086_PE5 NOISO LWTFGDGEQVIGQFKPPYNESFQVPDPTVAQVLVEHNITHTYTV---PGEYNLTLLVSST XENTR27_4_PE10 ISOFORMIN NWTFGDGTNQVYQYSPPYNQSFSVPNPSVYQVLIENNVTHAYREAVWTGAYNITVCVSNM XENTR27_4_PE11 ISOFORMIN NWTFGDGTNQVYQYSPPYNQSFSVPNPSVYQVLIENNVTHAYREAVWTGAYNITVCVSNM XENTR27_4_PE12 ISOFORMIN NWTFGDGTNQVYQYSPPYNQSFSVPNPSVYQVLIENNVTHAYREAVWTGAYNITVCVSNM XENTR27_4_PE8 ENSXETG00000015945 NWTFGDGTNQVYQYSPPYNQSFSVPNPSVYQVLIENNVTHAYREAVWTGAYNITVCVSNM XENTR27_4_PE9 ISOFORMIN NWTFGDGTNQVYQYSPPYNQSFSVPNPSVYQVLIENNVTHAYREAVWTGAYNITVCVSNM MATCH :** . . * : . . CONSENSUS ?W?FGDG????????PPY??S???P?????QVL???N??H?Y?????PG?Y??????SN?

AILMEGL193445_1_PE11 NOISO FENLTQQVPVSVRATLPAVAVAVGSRVLVAGQSVTFSPHPLPSPGGILYTWDFGDGSPAV ANOCA1218_PE2 NOISO FENLTYSVPIHIYSYLMDLTMEADTDVLVAGRPVTFKAHPLPSGFGVSYVWDFGDDSMVY BOVIN25_3_PE13 NOISO FENLTQQVPVSVRAALPAVAVAVGSQVLVAGRPVAFFPRPLPSPGGVLYTWDFGDGSPAV CALJA12_3_PE50 ENSCJAG00000015073 FENLTKQVPVSVRSVLPSVAVGMSDSVLVAGRPVTFYPHPLPAPGGVLYIWDFGDGSPVL CANFA6_43_PE42 NOISO FENLTQQVPVSVRATLPAVAVAVGSHVLVAGQPVTFSPHPLPSPGGILYTWDFGDGSPAV CAVPO4_23_PE41 NOISO FENLTQQVPVSVRDTLPAVAISVSSSTLVAGWPVIFSLYPLPLPGGVLYMWNFGDDSPVL CHICK14_PE230 ENSGALG00000005714 FENLTCLTPVRVHSYLVDVQIETVKDVLVVNRSVTFRAIPLPSPYGVLYTWDFGDGSSLV CHICK14_PE231 ISOFORMIN FENLTCLTPVRVHSYLVDVQIETVKDVLVVNRSVTFRAIPLPSPYGVLYTWDFGDGSSLV DANRE1_57_PE22 NOISO YENKTCKVDVYVFSILTSVQIEVYPPLLRAEKPADFEAHPLPSPYGIIYTWNFGDNSSIQ DIPORGS_421_PE4 NOISO YENMTQQVPVSVRPALPSLAVGASRSVLVVGQPVTFSPHPRPLSGGILYAWDFGDGSPRL ERIEUGS_1621_PE2 NOISO FENLTRQVTVSVRATLPTVSVIVDSCVLVAGQPVIFSSTPLPSPGNILYTWDFGDGSLAV FELCAGS_5159_PE2 NOISO FENLTRQVSVSVRATLPAVAVAVGSRVLVAGQSVTFAPRPLPSPGGILYTWDFGDGSPAV FUGRU189_PE62 ISOFORMIN YENISRSINMSVYSILTRVDIQTEPSLLLAGKTADFEAHPLPSPYGIHYEWNFGDGSALL FUGRU189_PE63 ISOFORMIN YENISRSINMSVYSILTRVDIQTEPSLLLAGKTADFEAHPLPSPYGIHYEWNFGDGSALL FUGRU189_PE64 ENSTRUG00000008067 YENISRSINMSVYSILTRVDIQTEPSLLLAGKTADFEAHPLPSPYGIHYEWNFGDGSALL FUGRU189_PE65 ISOFORMIN YENISRSINMSVYSILTRVDIQTEPSL--------------------------------- GASACGROUPIX_16_PE21 ENSGACG00000018946 YENISQSINMSVYSILTRVDIQTEPLLLLTGKSADFEAHPLPSPYGIHYDWHFGDGSALL GORGO16_3_PE27 ENSGGOG00000007016 FENLTQQVPVSVRTSLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVL HORSE13_41_PE34 ENSECAG00000006899 FENLTQQVPISVRAALPAVAVAVSSQVLVAGHPVTFSLHPLPSPGGVLYTWDFGDGSPAM HORSE13_41_PE35 ISOFORMIN FENLTQQVPISVRAALPAVAVAVSSQVLVAGHPVTFSLHPLPSPGGVLYTWDFGDGSPAM HS16_PE357 ENSG00000008710 FENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVL HS16_PE358 ISOFORMIN FENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVL HS16_PE359 ISOFORMIN FENLTQQVPVSVRASLPSVAVGVSDGVL-------------------------------- HS16_PE360 ISOFORMIN FENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVL LOXAF53_15_PE1 NOISO FENLTQQMPIHVRTALPTLAVGMSTCVLVVGRPVTFFPLPSPLPGGVLYTWDFGDSYPIG MACEUGS_650_PE4 NOISO FENLTQQVPLSVRASLPHVTVETDSGALVVGRPITFTPCPLPSPAGVLYTWDFGDGSPAV MICMUGS_282_PE3 NOISO LENLTQQVPVSVRATLPAVAVGMSSSILVTGQPVTFYPQPLPSPGGILYTWDFGDGSPIL MONDO6_161_PE25 ISOFORMIN LENLTQQVPLSVRASLPHVTVRTDSGALG------------------------------- MONDO6_161_PE26 ENSMODG00000016034 LENLTQQVPLSVRASLPHVTVRTDSGALGVGHPITFMPHPLPSPTGILYTWDFGDGSPVV MONDO6_161_PE27 ISOFORMIN LENLTQQVPLSVRASLPHVTVRTDSGALGVGHPITFMPHPLPSPTGILYTWDFGDGSPVV MONDO6_161_PE28 ISOFORMIN LENLTQQVPLSVRASLPHVTVRTDSGALGVGHPITFMPHPLPSPTGILYTWDFGDGSPVV MOUSE17_PE457 NOISO YENLTQQVTVSVRTVLPNVAIGMSSNVLVAGQPITFSPYPLPSTDGVLYTWDFGDGSPVL MYOLUGS_6259_PE4 NOISO FENLTQLVPVSVRAILPAVAVAVGSPVLVAGRPVTFSPHPLPSPGSILYTWDFGDGSPAM OCHPRGS_50_PE1 NOISO FENLTQQVPVSVRSTLPSVALCVSSSVLVAGRLVTFLPCPLPSPGGILYTWDLGDGSPAL ORYLA1073_PE1 NOISO YENISQTINMSVYSILTRVDLQTEPQLLLVGKSADFEAHPLPSPYGIHYTWHFGDGSALQ PIG3_37_PE90 NOISO FENLTQQVPVSVRAALPIVAVAMGSRVLVAGWPVTFFPHPLPLPGGVLYTWDFGDGSPAV POEGU14_10_PE12 NOISO YENLTHLSPVQVHSYLVDVKVEAEEDVLVVGRPVTFRAAPLPSPYGVVYTWDFGDGSSLL PONPY16_3_PE15 ENSPPYG00000006987 FENLTQQVPVSVRAALPSVAVGVSDSVLVAGRPITFYPHPLPSPGGVLYMWDFGDGSPVL PONPY16_3_PE16 ISOFORMIN FENLTQQVPVSVRAALPSVAVGVSDSVL-------------------------------- PROCAGS_6650_PE5 NOISO LENLTQQMAIHVRTALPALAVEVSSPVLVSRRPVTFFTWPSPSPGGGLYTWDFGDGSHSG PTEVAGS_3466_PE5 NOISO FENLTQLVPVSVRPTLPAMAVAVGSAVLVAGRPVTFSPHPLPSPGGVLYTWDFGDGSPAM RAT10_PE262 NOISO YENLTQQVPVSVRTVLPNVTIGMSSNVLLAGQPITFFPYPLPSADGVLYTWDFGDGSPVL TETNG18_PE189 ENSTNIG00000014075 HENVSQSINMSVYSILTRVDIQTEPSLLLAGKMADFEAHPLPSPYGIHYEWDFGDGSPML TETNG18_PE190 ISOFORMIN HENVSQSINMSVYSILTRVDIQTEPSLLLAGKMADFEAHPLPSPYGIHYEWDFGDGSPML TURTRGS_3086_PE5 NOISO FENLTQQVPVSVRATLPAVAVAAGSRVLVAGWPVTFFPHPLPSPGGVLYTWDFGDGSPDV XENTR27_4_PE10 ISOFORMIN HENRSQLIPLQVQSILTNLSITVE-AVLVSGQQAIFQAEVEPSAFEVQYDWDFGDGTEEF XENTR27_4_PE11 ISOFORMIN HENRSQLIPLQVQSILTNLSITVE-AVLVSGQQAIFQAEVEPSAFEVQYDWDFGDGTEEF XENTR27_4_PE12 ISOFORMIN HENRSQLIPLQVQSILTNLSITVE-AVLVSGQQAIFQAEVEPSAFEVQYDWDFGDGTEEF XENTR27_4_PE8 ENSXETG00000015945 HENRSQLIPLQVQSILTNLSITVE-AVLVSGQQAIFQAEVEPSAFEVQYDWDFGDGTEEF XENTR27_4_PE9 ISOFORMIN HENRSQLIPLQVQSILTNLSITVE-AVLVSGH---------------------------- MATCH ** : : : * : : CONSENSUS ?EN????????V???L??V????????L??G????F???P?PS?????Y?W?FGDGS???

AILMEGL193445_1_PE11 NOISO TQPQPEVNHTYASRGVYRVRLEVNNTVSSVAACISIRVFEALRGLSVSLSPAVEQGVPVT ANOCA1218_PE2 NOISO VESQPTIVHTYNTKGIYNVSLRANNTISTMETFWCYRVFEEITGLHVTMEEAIEVLMPLE BOVIN25_3_PE13 NOISO TQPQPEVNHTFALRGTYRVRLEVNNTVSHTVADVSVRVFEELCGLTVSLSPAVEQGVPTV CALJA12_3_PE50 ENSCJAG00000015073 MQSQPATNHTYTSRGTYRVRLEVNNTVSSAVAQADLRVFEELRGLSVDMSLAVEQGAPVV CANFA6_43_PE42 NOISO TQHQTEVSHTYASRGIYRIHLEVNNTVSSVTAWTSVRVFEELRGLSVSLSPSVEQGAPVT CAVPO4_23_PE41 NOISO IQSQPMVNYTYTRTGTYHICLEVNNTVSSVVAHTDVHVFQELSGLSVQLSPAVEQGAPVV CHICK14_PE230 ENSGALG00000005714 TESQSTVTYSYSSRGVYNISVSANNTINSVETVECYQVFEEITGLHVAADEVAEVGATVT CHICK14_PE231 ISOFORMIN TESQSTVTYSYSSRGVYNISVSANNTINSVETVECYQVFEEITGLHVAADEVAEVGATVT DANRE1_57_PE22 NOISO QGRERRVPHAYTHSGIYNICVNVNNSISSTDTCANIIVYEDIKGLEVMSSAPTEHNTPTV DIPORGS_421_PE4 NOISO VQSQPAVNHTYLHPGTYRVSLEVNNTVSSVGAYTDVHVFRELRGLSVHLSPAVEQGAPVA ERIEUGS_1621_PE2 NOISO TQLQPAISHTYTSRGWYSIRLEVNNTVSRRVAETSVHVLEELRGLSVSLSQTVEQGVPVV FELCAGS_5159_PE2 NOISO TQHRPEVNHTYSSGGEYRVRLEVNNTVSSVTACVGIRVFEELRGLSVSLSPSVEQGAPVT FUGRU189_PE62 ISOFORMIN QGR--RVAHTFEKSGPFNVCVSVNNTISSTAVCTEMFAYEEIESLTAESSSPTELHSATT FUGRU189_PE63 ISOFORMIN QGR--RVAHTFEKSGPFNVCVSVNNTISSTAVCTEMFAYEEIESLTAESSSPTELHSATT FUGRU189_PE64 ENSTRUG00000008067 QGR--RVAHTFEKSGPFNVCVSVNNTISSTAVCTEMFAYEEIESLTAESSSPTELHSATT FUGRU189_PE65 ISOFORMIN LGR--RVAHTFEKSGPFNVCVSVNNTISSTAVCTEMFAYEEIESLTAESSSPTELHSATT GASACGROUPIX_16_PE21 ENSGACG00000018946 RGR--RVAHTFAQSGVFNVCVHVNNTISSMDACAEMFVYEEVGDLTAESSSPTELHSPTT GORGO16_3_PE27 ENSGGOG00000007016 TQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVV HORSE13_41_PE34 ENSECAG00000006899 MQHQPEVNHTYAWRGTYRIRLEVNNTVSSAVTCTSVRVFEELRGLSVSLSPAVEQGAPVV