Alignment of the gene Family HOG000231104 of HOGENOM

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Isoforms are ON
AILMEGL192703_1_2_PE12 NOISO ------------------------------------------------------------ ANOCA19_5_PE8 NOISO ------------------------------------------------------------ BOVIN19_58_PE40 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGTLWPHRGAGGAGGPGGTARCPLCQEPY CALJA5_130_PE62 ENSCJAG00000013980 DGSGPFSCPICLEPLREPVTLPCGHNFCLTCLGALWPHRGAAGAGGPGGAARCPLCQEPF CALJA5_130_PE63 ISOFORMIN DGSGPFSCPICLEPLREPVTLPCGHNFCLTCLGALWPHRGAAGAGGPGGAARCPLCQEPF CALJA5_130_PE64 ISOFORMIN ------------------------------------------------------------ CANFA9_8_PE36 NOISO ------ACSICLGLFQEPVTLPCGHIFCLGCLGALWPHRGAVGTGGPGGAARCPLCQEPF CAVPO193_1_PE14 NOISO DGSGPFGCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGAGGSGGAARCPLCQEPF DIPORGS_2764_PE8 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGPGGAARCPLCQEPF FELCAGS_4086_PE15 NOISO ------------------------------------------------------------ GORGO5_8_PE32 ENSGGOG00000009236 DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRG---AGGPGGAARCPLCQEPF GORGO5_8_PE33 ISOFORMIN DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRG---AGGPGGAARCPLCQEPF HORSE11_7_PE16 NOISO ------------------------------------------------------------ HS17_PE3001 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASGAGGPGGAARCPLCQEPF LOXAF49_7_PE30 NOISO DSPGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGVGGAGGPGSTARCPLCQEPF MACEUGS_4193_PE1 NOISO DVSGPFSCPICLEPLREPVTLPCGHNFCLACLEALWPHRGPGGPGGSGVTARCPLCQEPF MACMU16_75_PE24 NOISO DSSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASGAGGPGGAARCPLCQEPF MICMUGS_1603_PE17 NOISO ------------------------------------------------------------ MONDO2_220_PE17 NOISO DVSGPFNCPICLERLREPVTLPCGHNFCLSCLEALWPHRGPGGAGGPGNTARCPLCQEPF MOUSE11_PE4033 ISOFORMIN DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGSGGPARCPLCQEPF MOUSE11_PE4034 ENSMUSG00000020773 DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGSGGPARCPLCQEPF MYOLUGS_2358_PE1 NOISO DGCGTFSCPICPELAAEPVMLPCSHHFHLACLSVPWPHRSAGELGASGGTARLLLGQEPF OCHPRGS_2043_PE1 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGAGGTGGPGGAARCPLCQEPF ORNANCONTIG19997_PE2 ENSOANG00000012910 ------------------------------------------------------------ ORNANCONTIG19997_PE3 ISOFORMIN ------------------------------------------------------------ PANTR17_80_PE23 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASGAGGPGGAARCPLCQEPF PIG12_4_PE30 NOISO DGGWPFSCPICLEPLREPVTLPCGHNFCLACLSALWPHRGAGGAGGPGGTARCPLCQEPF POEGU18_9_PE20 NOISO -PEGPLGCPICLDVLRDPVTVPCGHNFCQGCLQELRQRPGPPDGGGAGGAARCPLCQEPV PONPY17_69_PE14 NOISO DCSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASGAGGPGGAARCPLCQEPF PTEVAGS_2976_PE26 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGTLWPHRGTGGASAPGGAARCPLCQEPF RABITUN1026_PE1 ENSOCUG00000006661 DGSGPFSCPICLEALREPVTLPCGHNFCLACLGALWPNRGAGSTGGPGGAARCPLCQEPF RABITUN1026_PE2 ISOFORMIN DGSGPFSCPICLEALREPVTLPCGHNFCLACLGALWPNRGAGSTGGPGGAARCPLCQEPF RAT10_PE2502 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGSGGPARCPLCQEPF SPETRGS_1349_PE4 NOISO DGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGSGGAARCPLCQEPF TURTRGS_2909_PE15 NOISO DGSGPFSCPICLESLRESVTLPCGHNFCLACLGALWPHRGACGAGGPGGTARCPLCQRAF MATCH CONSENSUS ????????????????????????????????????????????????????????????

AILMEGL192703_1_2_PE12 NOISO ------------------------------------------------------------ ANOCA19_5_PE8 NOISO ------------------------------------------------------------ BOVIN19_58_PE40 NOISO PDGLQLRKNQTLSELLQLRQGSGPGPGPCPAPAPSPCPAPAPGPAPAPEPATPSAPPSAP CALJA5_130_PE62 ENSCJAG00000013980 PDGLQLRKNHTLSELLQLRQGSGPGPGPGPATA------------PALEPSAPSAPPSAP CALJA5_130_PE63 ISOFORMIN PDGLQLRKNHTLSELLQLRQG--------------------------LEPSAPSAPPSAP CALJA5_130_PE64 ISOFORMIN ------------------------------------------------------------ CANFA9_8_PE36 NOISO PDGLQLRKNHTLSELLQLRQGSGSAPGPGPAPAPA------PAPAPAPEPTPPSAPPSAP CAVPO193_1_PE14 NOISO PDGLQLRKNHTLSELLQLRHGSGPGPMPTPAPTPARCPT--------PEPSAPSAPPSAT DIPORGS_2764_PE8 NOISO PDGLQLRKNHTLSELLQLRQGAGPGPMSSPTSGPAR----S----PTPEPSAPSAPPLAP FELCAGS_4086_PE15 NOISO ------------------------------------------------------------ GORGO5_8_PE32 ENSGGOG00000009236 PDGLQLRKNHTLSELLQLRQGSGPGPGPGPAPALA--------PEPSAPSA----PPSAP GORGO5_8_PE33 ISOFORMIN PDGLQLRKNHTLSELLQLRQG-----------ALA--------PEPSAPSA----PPSAP HORSE11_7_PE16 NOISO ------------------------------------------------------------ HS17_PE3001 NOISO PDGLQLRKNHTLSELLQLRQGSGPGSGPGPAPALA--------PEPSAPSAL----PSVP LOXAF49_7_PE30 NOISO PDGLQLRKNHTLAELLQLRLGSGPGKGPAPGL--------------APEPSAPSAPPNAP MACEUGS_4193_PE1 NOISO PDGLQLRKNHTLCELLQLRQSG-PSQTPA----------------PAPAP----SN-PDP MACMU16_75_PE24 NOISO PDGLQLRKNHTLSELLQLRQGSGPGPGPGPGPAPA--------PAPE--PSVPSAPPSAP MICMUGS_1603_PE17 NOISO --------------------------------------------------------PSTP MONDO2_220_PE17 NOISO PDGLQLRKNHTLCELLQLRQSG-PGQTPA----------------TAPAP----NQAPAL MOUSE11_PE4033 ISOFORMIN PDGLQLRKNHTLSELLQLRQGSVPGPMSAPASGSTR----G----ATPEPSAPSAPPPAP MOUSE11_PE4034 ENSMUSG00000020773 PDGLQLRKNHTLSELLQLRQGSVPGPMSAPASGSTR----G----ATPEPSAPSAPPPAP MYOLUGS_2358_PE1 NOISO PNGLA-RKNHMLSELLEPLQVGXXXXXXXXXXXXXXXXXXXXXX---XXXXX--X--XX- OCHPRGS_2043_PE1 NOISO PDGLQLRKNHTLSELLQLRQGSGPGPGPGPGPGTAS----APAPIPSPEPSVPSAPPSAP ORNANCONTIG19997_PE2 ENSOANG00000012910 ------------------------------------------------------------ ORNANCONTIG19997_PE3 ISOFORMIN ------------------------------------------------------------ PANTR17_80_PE23 NOISO PDGLQLRKNHTLSELLQLRQGSGPGPGPGPAPALA--------PEPSAPSAPPSAPPSAP PIG12_4_PE30 NOISO PDGLQLRKNHTLSELLQLRQGSGPGPGPGPAPTPAAALA----PEPAAPSAPPSSPPSAP POEGU18_9_PE20 NOISO PAALRLCKNRALCELLPLLAAATGASSPSPSA--------------------AASPTSPM PONPY17_69_PE14 NOISO PDGLQLRKNHTLSELLQLRQGSG-GPGPG---APA--------PEPSAPSAPPSAPPSTP PTEVAGS_2976_PE26 NOISO PDGLQLRKNHTLSELLQLRQGSGPGPGPGPGQ----------TPALAPEPAAPSAPPSAL RABITUN1026_PE1 ENSOCUG00000006661 PDGLQLRKNHTLSELLQLRQGSGPGPGPGPGSGSAP----GPTPVPNPEPSAPSAPPSAL RABITUN1026_PE2 ISOFORMIN PDGLQLRKNHTLSELLQLRQGSGPGPGPGPGSG--------------PEPSAPSAPPSAL RAT10_PE2502 NOISO PDGLQLRKNHTLSELLQLRQGSSPGPMSAPAPGSAR----G----ATPEPSAPSAPPPAP SPETRGS_1349_PE4 NOISO PDGLQLRKNHTLSELLQLRQGSGPAM---------PSPAPAPARRPTPEPSAPSAQPSAP TURTRGS_2909_PE15 NOISO PDGL-LRKNQTLSELLQLRQGSGLGPGTSPARAPQSL----------APSAPPSAPPTPP MATCH CONSENSUS ????????????????????????????????????????????????????????????

AILMEGL192703_1_2_PE12 NOISO -------------------------GLPLPAALSCLSCLASFCPAHLGPHERSPALRGHR ANOCA19_5_PE8 NOISO ------------------------------AAQSCLVCLASFCAAHLQPHLRSPAFQGHR BOVIN19_58_PE40 NOISO EPSAPCAPESWPPGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR CALJA5_130_PE62 ENSCJAG00000013980 EPSAPCAPEPWPEGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR CALJA5_130_PE63 ISOFORMIN EPSAPCAPEPWPEGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR CALJA5_130_PE64 ISOFORMIN ------------------------------------------------------------ CANFA9_8_PE36 NOISO EPSAPCAPEPWPGGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHDRSPALRGHR CAVPO193_1_PE14 NOISO EPSAPSAPPSWAPAEESVHCDACPEGAVLPAALSCLTCLASFCPAHLGPHERSSRAARER DIPORGS_2764_PE8 NOISO EPSAPCAPEPWATGEEPVRCDACPEGAARPAARSCLSCLASFCAAHLGPHERSPALRGHR FELCAGS_4086_PE15 NOISO ------------------------------------------------------------ GORGO5_8_PE32 ENSGGOG00000009236 EPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR GORGO5_8_PE33 ISOFORMIN EPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR HORSE11_7_PE16 NOISO ------------------------------------------------------------ HS17_PE3001 NOISO EPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR LOXAF49_7_PE30 NOISO EPSAPCAPESWPATEELVRCDACPEGAALPAAFSCLSCLASFCPAHLGPHERSPALRGHR MACEUGS_4193_PE1 NOISO EPSAPCAPEPWPEGEEPVRCDACPEGAALPAARSCLSCLASFCTAHLKPHERSPALRGHR MACMU16_75_PE24 NOISO EPSAPCAPEPWSAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR MICMUGS_1603_PE17 NOISO ERSASFAPEPWPEGEGLVRCDACPEGAALPAALSCLSCLASFCPAHLGPHGRSPALRGHR MONDO2_220_PE17 NOISO EPSAPCAPEPWPEGEEPVRCDACPEGAALPAAKSCLSCLASFCTAHLRPHERSPALRGHR MOUSE11_PE4033 ISOFORMIN EPSAPCAPEQWPAGEEPVRCDACPEGAALPAALSCLSCLASFCSAHLAPHERSPALRGHR MOUSE11_PE4034 ENSMUSG00000020773 EPSAPCAPEQWPAGEEPVRCDACPEGAALPAALSCLSCLASFCSAHLAPHERSPALRGHR MYOLUGS_2358_PE1 NOISO X-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPAHLGH--ERSALRGHR OCHPRGS_2043_PE1 NOISO EPSAPSAPEPWPEGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR ORNANCONTIG19997_PE2 ENSOANG00000012910 --------------EEPVPCDACPEGAAQPAVRSCLPCLASFCPAHLGPHQRNPALRHHR ORNANCONTIG19997_PE3 ISOFORMIN --------------EEPVPCDACPEGAAQPAVRSCLPCLASFCPAHLGPHQRNPALRHHR PANTR17_80_PE23 NOISO EPSAPCAPEPWPAGEEPVRCDACLEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR PIG12_4_PE30 NOISO EPSAPSAPEPWPEGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR POEGU18_9_PE20 NOISO APGAEEEDAAGEEGGAVVLCDVCPPESRGAAERSCLVCLASFCGAHLEPHRRAPAFRAHR PONPY17_69_PE14 NOISO EPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR PTEVAGS_2976_PE26 NOISO EPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR RABITUN1026_PE1 ENSOCUG00000006661 EPSAPCAPEPWPEGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR RABITUN1026_PE2 ISOFORMIN EPSAPCAPEPWPEGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR RAT10_PE2502 NOISO EPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCSAHLAPHERSPALRGHR SPETRGS_1349_PE4 NOISO EPSAPCEPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHR TURTRGS_2909_PE15 NOISO EPTAPCAPDPDPADEYPERXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX MATCH CONSENSUS ??????????????E??V?CD?C??G???PA??SCL?CLASFC?AHL?PH?R?PALR?HR

AILMEGL192703_1_2_PE12 NOISO LVPPLRRLE-------------XCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ ANOCA19_5_PE8 NOISO LVAPSPRLEDRLCRLHLRPLEAFCRNDGACLCLLCKADPQHRGHQAVALEDERQRAQAQT BOVIN19_58_PE40 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERLCLCEACAAQE-HRGHELVPLEQERALQEAEQ CALJA5_130_PE62 ENSCJAG00000013980 LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEVGR CALJA5_130_PE63 ISOFORMIN LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEVGR CALJA5_130_PE64 ISOFORMIN ------------------------------------------------------------ CANFA9_8_PE36 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEADQ CAVPO193_1_PE14 NOISO PGAPRCAGWRRACAASLRPLEATCRPERLCLCEACAAQE-HRGHELVSLEQERALQEAEQ DIPORGS_2764_PE8 NOISO LVPPLRRLEESLCPRHLRPLERFCRAERLCLCQACAAQE-HRGHELVPLEQERALQEAEQ FELCAGS_4086_PE15 NOISO ---------------------------------------------------------AEQ GORGO5_8_PE32 ENSGGOG00000009236 LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ GORGO5_8_PE33 ISOFORMIN LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ HORSE11_7_PE16 NOISO --------------------------------------------------------QAEQ HS17_PE3001 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ LOXAF49_7_PE30 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAVQE-HRGHELVPLEQERALQEAEQ MACEUGS_4193_PE1 NOISO LVPPLRRLEESLCARHLRPLERYCRTERVCVCDACAAQE-HQGHELLSLEQERALQEAES MACMU16_75_PE24 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ MICMUGS_1603_PE17 NOISO LVPPLRRLEESLCPRHLRPLERFCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ MONDO2_220_PE17 NOISO LVPPLRRLEESLCARHLRPLERYCRTERVCVCDVCADQE-HHGHELLSLEQERALQEAES MOUSE11_PE4033 ISOFORMIN LVPPLRRLEESLCPRHLRPLERYCRVERVCLCEACATQD-HRGHELVPLEQERALQEVEQ MOUSE11_PE4034 ENSMUSG00000020773 LVPPLRRLEESLCPRHLRPLERYCRVERVCLCEACATQD-HRGHELVPLEQERALQEVEQ MYOLUGS_2358_PE1 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ OCHPRGS_2043_PE1 NOISO LV-PLRRLEESLCPRHLRPLERYCRVERVCLCEACAAQE-HRGHELVSLEQERELQEAEQ ORNANCONTIG19997_PE2 ENSOANG00000012910 LVPTLRRLEDSLCRRHLSPLDRYCRTHRLCLCATCAHQD-HRGHDLLDLDQERALQEVSP ORNANCONTIG19997_PE3 ISOFORMIN LVPTLRRLEDSLCRRHLSPLDRYCRTHRLCLCATCAHQD-HRGHDLLDLDQERALQEVSP PANTR17_80_PE23 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ PIG12_4_PE30 NOISO LVPPLRRLEESLCPRHLRPLERYCRADRVCLCETCAAQE-HRGHELVPLEQERALQEAEQ POEGU18_9_PE20 NOISO LVAPLRRLEEGLCPRHLQPLDGFCRTEQSCVCARCRAHE-HRAHDVVPL-AEREHKQAQQ PONPY17_69_PE14 NOISO LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HRGHELVPLEQERALQEAEQ PTEVAGS_2976_PE26 NOISO LVPPLRRLEESLCPRHLRPLERYCRGERVCLCEACATQE-HRGHELVPLEQERALQEAEQ RABITUN1026_PE1 ENSOCUG00000006661 LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HCGHELVALEQERALQEAEQ RABITUN1026_PE2 ISOFORMIN LVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQE-HCGHELVALEQERALQEAEQ RAT10_PE2502 NOISO LVPPLRRLEESLCPRHLRPLERYCRVERVCLCEACATQE-HRGHELVPLEQERALQEVEQ SPETRGS_1349_PE4 NOISO LVPPLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXAEQ TURTRGS_2909_PE15 NOISO XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLCEACAVQE-HRGHELVSVEQERALQEAEQ MATCH CONSENSUS LV?PLRRLE??LC??HL?PL???CR??R?CLC??CA?Q??H?GH?L??LEQERALQE???

AILMEGL192703_1_2_PE12 NOISO SKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAL-------AERE----RVSRLF ANOCA19_5_PE8 NOISO PKILSSVESQLDELG--VLIAQTKRT----VDLIKGTAQ-------KEKE----KVSKLF BOVIN19_58_PE40 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF CALJA5_130_PE62 ENSCJAG00000013980 GDTRVGREGRAGVHG--SGGQAHRAS----VQLFRGASV-------AERE----RVSRLF CALJA5_130_PE63 ISOFORMIN GDTRFAVVEMGREEGGTKGTSLGCRH----VWHMMSAAV-------AERE----RVSRLF CALJA5_130_PE64 ISOFORMIN ---------------------------------VQSAAV-------AERE----RVSRLF CANFA9_8_PE36 NOISO SKVLSAVEDRMDEL--GAGIALSRRT----VALIKSAAL-------AERE----KVSRLF CAVPO193_1_PE14 NOISO PKVLSAVEDRMDEL--AAGIAQSRRT----VALIKSAAV-------AERE----RVSQLF DIPORGS_2764_PE8 NOISO PKVLSAVDDRMDEL--GASIAQSRRT----VALIKSAAV-------AERE----RVSQLF FELCAGS_4086_PE15 NOISO SKVLSAVEDRMDEL--GACIAQSRRT----VALIKSAAA-------AERE----RVSRLF GORGO5_8_PE32 ENSGGOG00000009236 SKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF GORGO5_8_PE33 ISOFORMIN SKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF HORSE11_7_PE16 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAA-------AERE----RVSRLF HS17_PE3001 NOISO SKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF LOXAF49_7_PE30 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVNRLF MACEUGS_4193_PE1 NOISO PEVLSAADDRLDEL--GASIAQSRRT----VALIKSAAL-------TERV----KVSQLF MACMU16_75_PE24 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF MICMUGS_1603_PE17 NOISO PKVLSAVEDRMDEL--GASIAQSRRT----VALIKSAAV-------AERE----RVSRLF MONDO2_220_PE17 NOISO PQVLSAAEDRLDEL--GASIAQSRRT----VALIKSAAL-------TERE----KVSQLF MOUSE11_PE4033 ISOFORMIN SKVLSAAEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSQMF MOUSE11_PE4034 ENSMUSG00000020773 SKVLSAAEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSQMF MYOLUGS_2358_PE1 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSQLF OCHPRGS_2043_PE1 NOISO PKVLSAVEERMDEL--GASIAQSRRT----VALIKSAAV-------AERE----RVSQLF ORNANCONTIG19997_PE2 ENSOANG00000012910 ARIRSLSAGRVPGSGPSAGGDPGTSGGPAVFGPVRPTSVSLRGRRGAEESRDSPRVARLN ORNANCONTIG19997_PE3 ISOFORMIN ARIRSLSAGRVPGSGPSAGGDPGTSGGPAVFGPVRPTSVSLRG----------------- PANTR17_80_PE23 NOISO SKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF PIG12_4_PE30 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF POEGU18_9_PE20 NOISO AKFLSDAENELQELA--VTITQAKKM----VELIKGAAT-------KERE----RVEKLF PONPY17_69_PE14 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSRLF PTEVAGS_2976_PE26 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAA-------AERE----RVSRLF RABITUN1026_PE1 ENSOCUG00000006661 PKVLSEVEDRMDEL--GAGIAQARRT----VALIKSAAV-------AERE----RVSRLF RABITUN1026_PE2 ISOFORMIN PKVLSEVEDRMDEL--GAGIAQARRT----VALIKSAAV-------AERE----RVSRLF RAT10_PE2502 NOISO SKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSAAV-------AERE----RVSQMF SPETRGS_1349_PE4 NOISO PKVLSAVEDRMDEL--GACIAQSRRT----VALIKSAAV-------AERE----RVSQLF TURTRGS_2909_PE15 NOISO PKVLSAVEDRMDEL--GAGIAQSRRT----VALIKSTAV-------AERE----RVSRLF MATCH . :: CONSENSUS ?KVLS??E?R?DEL???A?IAQ?RRT????VALIKSAA????????AERE????RVS?LF

AILMEGL192703_1_2_PE12 NOISO AEA-----AAILQGFQTEV-LGFIEEGEATMLGRSQGDLRRQEEQRDRLSRARHNLGQVP ANOCA19_5_PE8 NOISO VET-----ARVLAAFQKEV-LGFIDDGERAMLSAAEEELRQKEERHAMLNECRKNLEKVS BOVIN19_58_PE40 NOISO AEA-----AAVLQGFQTQV-LGFIDEGEATMLGRSQGDLRRQEEQRSRLSRARHNLSQVP CALJA5_130_PE62 ENSCJAG00000013980 AEA-----AATLQGFQTEV-LSFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVP CALJA5_130_PE63 ISOFORMIN AEA-----AATLQGFQTEV-LSFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVP CALJA5_130_PE64 ISOFORMIN AEA-----AATLQGFQTEV-LSFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVP CANFA9_8_PE36 NOISO TEA-----AAILQGFQTEV-LGFIEEGEATMLGRSQGDLRRQEEQRSRLSRARHNLSQVP CAVPO193_1_PE14 NOISO AEA-----VATLQSFQKEV-LGFIEEGEVLMLGRSQGDLRRQEEQRGRLSRARQSLSQVP DIPORGS_2764_PE8 NOISO AEA-----AAALQGFQTEL-LGFIKEGESALLSRSQGDLWRQEEQRSRLSRARHNLSQVP FELCAGS_4086_PE15 NOISO AEA-----AAILQGFQTEV-LGFIEEGEATMLGRXXXXXXXXXXXXXXXXXXXXXXXXXX GORGO5_8_PE32 ENSGGOG00000009236 ADA-----AATLQGFQTQV-LGFIEEGEAAMLGCSQGDLRRQEEQRSRLSRVRQNLSQVP GORGO5_8_PE33 ISOFORMIN ADA-----AATLQGFQTQV-LGFIEEGEAAMLGCSQGDLRRQEEQRSRLSRVRQNLSQVP HORSE11_7_PE16 NOISO AEA-----AATLQGFQTEV-LGFIEEGEATMLGRSQGELRRQEEQRSRLSQARHKLSQVP HS17_PE3001 NOISO ADA-----AAALQGFQTQV-LGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVP LOXAF49_7_PE30 NOISO AEA-----EVTLQRFQAEV-LGFIEEGETTMLGRSQGDLRRQEEQRSRLSRARHNLSQVP MACEUGS_4193_PE1 NOISO TEA-----IGALQGFQSEV-MGFIAEGEAVMLSRAQGELRQQEEQRTRLSSARQNLSQGS MACMU16_75_PE24 NOISO AEA-----AAALQGFQTQV-LAFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVP MICMUGS_1603_PE17 NOISO AEA-----TATLQGFQT-V-LGFIEEGVAAMLGRSQGDLQRQEEQRSRLSRARHNLSQVP MONDO2_220_PE17 NOISO TEA-----IGTLQGFQSEV-MGFIAEGEAAMLGRAQGELRQQEEQRARLSSARQNLNQGP MOUSE11_PE4033 ISOFORMIN AEA-----TATLQSFQNEV-MGFIEEGEATMLGRSQGDLRRQEEQRSRLSKARHNLGQVP MOUSE11_PE4034 ENSMUSG00000020773 AEA-----TATLQSFQNEV-MGFIEEGEATMLGRSQGDLRRQEEQRSRLSKARHNLGQVP MYOLUGS_2358_PE1 NOISO AEA-----AATLQGFQKEV-LGFIEEGEAAMLSRSQGDLRRQEEQRSRLSRARHNLSQVP OCHPRGS_2043_PE1 NOISO AEA-----MAALQGFQTHV-LAFIEEGEATMLGRSQGDLRRQEEQRSRLSRARHNLGQVP ORNANCONTIG19997_PE2 ENSOANG00000012910 RRPLTPRRPAPAAGLRNAPAAGGGPRAGTREPGRVDAGLWQQA------------DSQDP ORNANCONTIG19997_PE3 ISOFORMIN --------PAPAAGLRNAPAAGGGPRAGTREPGRVDAGLWQQVNNNVPTGE---ADSQDP PANTR17_80_PE23 NOISO ADA-----AATLQGFQTQV-LGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVP PIG12_4_PE30 NOISO AEA-----AAVLQRFQTEV-LGFIDEGEATMLGHSQGDLRRQEDQRSRLSQARHNLSQVP POEGU18_9_PE20 NOISO AEA-----SEVLAAFQKEV-TGFIEDEERSMLGEAEADLRWKEQRRAKLAQCKQSLENVP PONPY17_69_PE14 NOISO AEA-----AAALQGFQTQV-LGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVP PTEVAGS_2976_PE26 NOISO AXX-----XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNLSQVP RABITUN1026_PE1 ENSOCUG00000006661 AEA-----AAALQGFQTQV-LGFIEEGEASMLGRSQGDLRRQEEQRSRLSRARHNLSQVP RABITUN1026_PE2 ISOFORMIN AEA-----AAALQGFQTQV-LGFIEEGEASMLGRSQGDLRRQEEQRSRLSRARHNLSQVP RAT10_PE2502 NOISO AEA-----TASLQSFQTEV-LGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARHNLSQVP SPETRGS_1349_PE4 NOISO AEA-----AATLQGFQTEV-LGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARHNLGQVP TURTRGS_2909_PE15 NOISO AEA-----AAVLQGFQAEV-LSFIDEGEATMLGRSQGDLRRQEGQRSRLSRARHNLGQVP MATCH CONSENSUS AEA??????A?LQ?FQ??V??GFI?EGE??MLGR?QG?LR?QEEQR?RLS??R?NL?QVP

AILMEGL192703_1_2_PE12 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDALTAA ANOCA19_5_PE8 NOISO STD--------TISFLQ-EFQALKIAAEENNFSSASFPKELSFIKSSQAVCTVKEWLVNI BOVIN19_58_PE40 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPKELSFTKSSQAVRAVRAVLAAA CALJA5_130_PE62 ENSCJAG00000013980 EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLTAA CALJA5_130_PE63 ISOFORMIN EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLTAA CALJA5_130_PE64 ISOFORMIN EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLTAA CANFA9_8_PE36 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLAAA CAVPO193_1_PE14 NOISO EAD--------SVSFLQ-EFLALRLALEEGCGPGPSPPRELSFTKSSQAVRAVRDVLASA DIPORGS_2764_PE8 NOISO EAD--------SVSFLQ-EFLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDALVSA FELCAGS_4086_PE15 NOISO XXX--------XXXXXX-ELLALRLALEEGCGPGPGPPRELSFTRSSQAVRAVRELLTAT GORGO5_8_PE32 ENSGGOG00000009236 EAD--------SVSFLQ-ELLALRLALEDGCGPGPGPPRELSFTKSSQAVRAVRDMLAVA GORGO5_8_PE33 ISOFORMIN EAD--------SVSFLQ-ELLALRLALEDGCGPGPGPPRELSFTKSSQAVRAVRDMLAVA HORSE11_7_PE16 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPKELSFTKSSQAVRAVRDVLTAA HS17_PE3001 NOISO EAD--------SVSFLQ-ELLALRLALEDGCGPGPGPPRELSFTKSSQAVRAVRDMLAVA LOXAF49_7_PE30 NOISO EAD--------SVGFLQ-ELLALRLALEEGCGPGSGPPRELSFTKSSQAVQTVKELLAAA MACEUGS_4193_PE1 NOISO EID--------SISFLQ-ELLALKLALEEGGSSGSGPPKELSFTKSSQAVKAVRDLLTLA MACMU16_75_PE24 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLAVA MICMUGS_1603_PE17 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFIKSSQAVRGVRDVLAEA MONDO2_220_PE17 NOISO EID--------SISFLQ-ELLALKLALEEGGGLGSGPPKELSFTKSSQAVKAVRDLLTLA MOUSE11_PE4033 ISOFORMIN EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQVVKAVRDTLISA MOUSE11_PE4034 ENSMUSG00000020773 EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQVVKAVRDTLISA MYOLUGS_2358_PE1 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELGFTKSSQAVKAVREVLAAA OCHPRGS_2043_PE1 NOISO EAD--------SVSFLQ-ELLTLKLALEEGCGPGPGLPTELSFTKSSQAVRAVRDMLVAA ORNANCONTIG19997_PE2 ENSOANG00000012910 DSSNSLECEEARDYFLK------------------------------------------- ORNANCONTIG19997_PE3 ISOFORMIN DSSNSLECEEARDYFLKCERLEDGGWGLGAGA-------GARGL----GSPPPCALEP-- PANTR17_80_PE23 NOISO EAD--------SVSFLQ-ELLALRLALEDGCGPGPGPPRELSFTKSSQAVRAVRDMLAVA PIG12_4_PE30 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPAPPRELSFTKSSQAVRKVRDVLASA POEGU18_9_PE20 NOISO STD--------TIYFLQ-EFQALKAAMEENLSPPLSFQKELNFTKCTQAVGAMKDVLSTA PONPY17_69_PE14 NOISO EAD--------SVSFLQ-ELLALRLALEDGCGPVPGPPRELSFTKSSQAVRAVRDMLAVA PTEVAGS_2976_PE26 NOISO EAE--------SVSSLQ-ELLAIRLALEEGCGPGPGPPRELSFTKSSQAVRAVTEVLTA- RABITUN1026_PE1 ENSOCUG00000006661 EAD--------SVSFLQQELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLAAA RABITUN1026_PE2 ISOFORMIN EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLAAA RAT10_PE2502 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDILVSA SPETRGS_1349_PE4 NOISO EAD--------SVSFLQ-ELLALRLALEEGCGPGPGPPRELSFTKSSQAVRAVRDVLASA TURTRGS_2909_PE15 NOISO EAD--------SVSFLQ-ELLELRLALEEGCGPGPGPPGELSFTKSSQAVQVVRDGLASA MATCH CONSENSUS EAD????????SVSFLQ?ELLALRLALEEGCGPGPGPP?ELSFTKSSQAV?AVR??L??A

AILMEGL192703_1_2_PE12 NOISO CASQWEQLRGLGGYEDELQKLGTEADAESQDPDSTNNLE---SEAPRDYFLKFAYIVDLD ANOCA19_5_PE8 NOISO CKNQWDLLSGKGADGTIPYGMPEGCQLP-S-CDTS---SDGPLDL-PDGFLSFAFIIDLD BOVIN19_58_PE40 NOISO CSSQWEQLRGLGGDEDGLQKPGTEADAESQDPDSTNNLE---SEAPRDYFLKFAYIVDLD CALJA5_130_PE62 ENSCJAG00000013980 CASQWEQLRGPGGNEDGPQKLDSEGRGPNPASGRSCHPEGSVNPLDHSLGQRVAYIVDLD CALJA5_130_PE63 ISOFORMIN CASQWEQLRGPGGNEDGPQKLDSEGRGPNPASGRSCHPEGSVNPLDHSLGS-VAYIVDLD CALJA5_130_PE64 ISOFORMIN CASQWEQLRGPGGNEDGPQKLDSEGGQPPDDSPSP----SLLHSLSLLSAGSVAYIVDLD CANFA9_8_PE36 NOISO CASQWEQLRGLGGDEDELQKLGTEADAESQDPDSTNNVE---SEAPRDYFLKFAYIVDLD CAVPO193_1_PE14 NOISO CASQWEQLREQGGDQDGLQKLGSEADAESQDPDSTNLLQ---SDAPRDYFLKFAYIVDLD DIPORGS_2764_PE8 NOISO CGSQWEQLRGLGGDADGLQKLGPEADVESQDADSTNLLD---SEAPRDYFLKFAYIVDLD FELCAGS_4086_PE15 NOISO CASQWEQLRGLG----------TEADAESQDPDSTNHLE---SEAPRDYFLKFAYIVDLD GORGO5_8_PE32 ENSGGOG00000009236 CVNQWEQLRGPGGNEDGPQKLDSEADAEPQDLESTNLLE---SEAPRDYFLKFAYIVDLD GORGO5_8_PE33 ISOFORMIN CVNQWEQLRGPGGNEDGPQKLDSEADAEPQDLESTNLLE---SEAPRDYFLKFAYIVDLD HORSE11_7_PE16 NOISO CSSQWEQLRGLGSDEDGLQKLGAE-DAGSQDPDSTDPLE---SEAPRDYFLKFAYIVDLD HS17_PE3001 NOISO CVNQWEQLRGPGGNEDGPQKLDSEADAEPQDLESTNLLE---SEAPRDYFLKFAYIVDLD LOXAF49_7_PE30 NOISO CASQWEELQGLGSDEDGLQKMGPEAEADFQDPDSTGRLE---SEAPRDYFLKFAYIVDLD MACEUGS_4193_PE1 NOISO CANQWEFLQGMVRDTDNSQKLGLEADGESQDPDSTNGLE---SEESRDYFLKFAFIVDLD MACMU16_75_PE24 NOISO CANQWEQLRGPGGNEDGPQKLDSEADAEPQDPDSTNLLE---SEAPRDYFLKFAYIVDLD MICMUGS_1603_PE17 NOISO CASQWEQLGGLDSDEDRL-KPGSEADAESQDPDSNNHLE---SEAPRDYFLKFAYIVDLD MONDO2_220_PE17 NOISO CANQWEFLQGMGRDTDNSPKLGSEADAESQDPDSTNGLE---CEESRDYFLKFAFIVDLD MOUSE11_PE4033 ISOFORMIN CASQWEQLRGLGSNEDGLQKLGSE-DVESQDPDSTSLLE---SEAPRDYFLKFAYIVDLD MOUSE11_PE4034 ENSMUSG00000020773 CASQWEQLRGLGSNEDGLQKLGSEADVESQDPDSTSLLE---SEAPRDYFLKFAYIVDLD MYOLUGS_2358_PE1 NOISO CASQWGQLRGLSGDEDGPHKLGPEADAESQDPDNSSHLD---SEVPRDYFLKFAYIVDLD OCHPRGS_2043_PE1 NOISO CTGQWGQLQGLGIDEDGLQKLGSEADAESQDPDSTNLLE---SEAPRDYFLKFAYIVDLD ORNANCONTIG19997_PE2 ENSOANG00000012910 ----------------------------------------------------FAFIVDLD ORNANCONTIG19997_PE3 ISOFORMIN --ESTQAPAGSVSRLAHPLSNPCSPKHLRQCSAAGRDPGSGLLSLSPAPGRSVAFIVDLD PANTR17_80_PE23 NOISO CVNQWEQLRGPGGNEDGPQKLDSEADAEPQDLESTNLLE---SEAPRDYFLKFAYIVDLD PIG12_4_PE30 NOISO CTSQWEQLQGLGSDEDGLQKPGTEAETETQDPDSTNSLE---SEAPRDYFLKFAYIVDLD POEGU18_9_PE20 NOISO CKNQWNHLQGKGIDGFNCQEMEEGNSSS-QDRQTS---SRGRLWAPKHARLPIAFIIDLD PONPY17_69_PE14 NOISO CVNQWEKLRGPGGNEDGPQKLDSEADAEPQDLDSTNLLE---SEAPRDYFLKFAYIVDLD PTEVAGS_2976_PE26 NOISO AANQWEQLRGLGSDEDGLQKLGTEADAESQDPDSTGQLE---SEAPRDYFLKFAYIVDLD RABITUN1026_PE1 ENSOCUG00000006661 CASQWQQLRGLGSDEEGLQKLGSEADAESQEPDSTNLLE---SEAPRDYFLKFAYIVDLD RABITUN1026_PE2 ISOFORMIN CASQWQQLRGLGSDEEGLQKLGSEADAESQEPDSTNLLE---SEAPRDYFLKFAYIVDLD RAT10_PE2502 NOISO CASQWEQLRGLGSGEDELQKLGSEADVESQDPDSTNLLE---SEAPRDYFLKFAYIVDLD SPETRGS_1349_PE4 NOISO CASQWEQLRGLGSD-DGPQKLGSEADSESQDPDSTNHLE---SDIPRDYFLKFAYIVDLD TURTRGS_2909_PE15 NOISO CTSQWEQLQGLGSDEDGLQKPGTEADAESQDPESANSLE---SEAPRDYFLKFAYIVDLD MATCH .*:*:*** CONSENSUS C??QW??L?G?G???D??QK???E?????QD??S????????????RDYFLKFAYIVDLD

AILMEGL192703_1_2_PE12 NOISO SDTADKYLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV ANOCA19_5_PE8 NOISO SDTADKFLQLFGTKGAKRVLNPIGYPENSTRFINCEQVLGENIMNRGNYYWEVEIIDGWV BOVIN19_58_PE40 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV CALJA5_130_PE62 ENSCJAG00000013980 SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV CALJA5_130_PE63 ISOFORMIN SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV CALJA5_130_PE64 ISOFORMIN SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV CANFA9_8_PE36 NOISO SDTADKYLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIDGWV CAVPO193_1_PE14 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGAMDRGTYYWEVEIIEGWV DIPORGS_2764_PE8 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV FELCAGS_4086_PE15 NOISO SDTADKYLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV GORGO5_8_PE32 ENSGGOG00000009236 SDTADKFLQLFGTKGVKRVLCPINYPLSPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV GORGO5_8_PE33 ISOFORMIN SDTADKFLQLFGTKGVKRVLCPINYPLSPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV HORSE11_7_PE16 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV HS17_PE3001 NOISO SDTADKFLQLFGTKGVKRVLCPINYPLSPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV LOXAF49_7_PE30 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV MACEUGS_4193_PE1 NOISO SDTADKFLQLFGTKGVKRVLCPISYPESPMRFTHCEQVLGEGSLDRGTYYWEVEIIEGWV MACMU16_75_PE24 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV MICMUGS_1603_PE17 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV MONDO2_220_PE17 NOISO SDTADKFLQLFGTKGVKRVLCPISYPESPMRFTHCEQVLGEGILDRGTYYWEVEIIEGWV MOUSE11_PE4033 ISOFORMIN SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV MOUSE11_PE4034 ENSMUSG00000020773 SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV MYOLUGS_2358_PE1 NOISO SDTADKFLQLFGTKGVKRVLCPISYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV OCHPRGS_2043_PE1 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV ORNANCONTIG19997_PE2 ENSOANG00000012910 SDTADKFLQLFGTKGVKRVLCPVAYPESPTRFVHCEQVLGGGALDRGTYYWEVEIIEGWV ORNANCONTIG19997_PE3 ISOFORMIN SDTADKFLQLFGTKGVKRVLCPVAYPESPTRFVHCEQVLGGGALDRGTYYWEVEIIEGWV PANTR17_80_PE23 NOISO SDTADKFLQLFGTKGVKRVLCPINYPLSPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV PIG12_4_PE30 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV POEGU18_9_PE20 NOISO SDTADKFIQLFGTKGAKRVLCPIPYPESPTRFINCEQVLGLNLMNRGNYYWEVELIDGWV PONPY17_69_PE14 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV PTEVAGS_2976_PE26 NOISO SDTADKFLQ--GTKGVKRVLCPPDYLESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV RABITUN1026_PE1 ENSOCUG00000006661 SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV RABITUN1026_PE2 ISOFORMIN SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV RAT10_PE2502 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV SPETRGS_1349_PE4 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV TURTRGS_2909_PE15 NOISO SDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV MATCH ******::* ****.**** * * .. ** :****** . ::**.******:*:*** CONSENSUS SDTADKFLQLFGTKGVKRVLCPI?YPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWV

AILMEGL192703_1_2_PE12 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEASLAHPFSPTVGICLE ANOCA19_5_PE8 NOISO SIGVITEDFNPQEPYDRGRLGRNEKSCCLQWNGQNYVAWFGGFDCVIQQPFFHTIGVFLE BOVIN19_58_PE40 NOISO SVGVMAEDFSPQEPYDRGRLGRNAYSCCLQWNGRSFSVWFHGQEAPLPHPFSPTVGICLE CALJA5_130_PE62 ENSCJAG00000013980 SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFYGLEAPLPHPFSPTVGVCLE CALJA5_130_PE63 ISOFORMIN SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFYGLEAPLPHPFSPTVGVCLE CALJA5_130_PE64 ISOFORMIN SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFYGLEAPLPHPFSPTVGVCLE CANFA9_8_PE36 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPQPFSPTVGICLE CAVPO193_1_PE14 NOISO SMGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRNFSVWFHGLEAALPHNFSPTVGICLE DIPORGS_2764_PE8 NOISO SVGVMAEGFSPQEPYDRGRLGRNGHSCCLQWNGRGFSVWFHGLEATLPHAFSPTVGVCLE FELCAGS_4086_PE15 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGICLE GORGO5_8_PE32 ENSGGOG00000009236 SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE GORGO5_8_PE33 ISOFORMIN SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE HORSE11_7_PE16 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLETPLPHPFSPTVGICLE HS17_PE3001 NOISO SMGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE LOXAF49_7_PE30 NOISO SMGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPQPFSPTVGICLE MACEUGS_4193_PE1 NOISO SVGVMAEDFSPREPYDRGRLGRNAYSCCLQWNGRNFSVWFYGLEAPLPHPFCPTVGVCLE MACMU16_75_PE24 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE MICMUGS_1603_PE17 NOISO SVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPQPFSPTVGVCLE MONDO2_220_PE17 NOISO SVGVMAEDFSPREPYDRGRLGRNAHSCCLQWNGRNFSVWFYGLEASLPHSFCPTVGVCLE MOUSE11_PE4033 ISOFORMIN SVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRGFSVWFCGLEAPLPHAFSPTVGVCLE MOUSE11_PE4034 ENSMUSG00000020773 SVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRGFSVWFCGLEAPLPHAFSPTVGVCLE MYOLUGS_2358_PE1 NOISO SVGVMAEDFSPHEPYDRGRLGRNAHSCCLQWNGRGFSVWFHGQEAPLPHAFSPTVGVCLE OCHPRGS_2043_PE1 NOISO SVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE ORNANCONTIG19997_PE2 ENSOANG00000012910 SVGVMAEDFSPREPYDRGRLGRNPFSCCLQWNGRNFSVWFHGLEAPLPQPFSPTVGVCLE ORNANCONTIG19997_PE3 ISOFORMIN SVGVMAEDFSPREPYDRGRLGRNPFSCCLQWNGRNFSVWFHGLEAPLPQPFSPTVGVCLE PANTR17_80_PE23 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE PIG12_4_PE30 NOISO SVGVMAEDFSPLEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAALPHPFSPTVGICLE POEGU18_9_PE20 NOISO SIGVIAEDFDPREAYNHGRLGRNDRSCCLQWNGQNYVAWFGGFECAIHQPFFHTIGVFLE PONPY17_69_PE14 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE PTEVAGS_2976_PE26 NOISO SMGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHAFSPTVGICLE RABITUN1026_PE1 ENSOCUG00000006661 SVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE RABITUN1026_PE2 ISOFORMIN SVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLE RAT10_PE2502 NOISO SVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRGYSVWFCGLEAPLPHAFSPTVGVCLE SPETRGS_1349_PE4 NOISO SVGVMAEGFSPQEPYDRGRLGRNAYSCCLQWNGRNFSVWFHGLEAALPQPFSPTVGICLE TURTRGS_2909_PE15 NOISO SVGVMAEDFSPQEPYDRGRLGRNAHSCC-QWNGRSFSVWFHGLELLLPHPFSPTVGICLE MATCH *:**::*.*.* *.*::****** *** ****:.: .** * : : : * *:*: ** CONSENSUS SVGVMAE?FSPQEPYDRGRLGRNAHSCCLQWNGR?FSVWF?GLEA?LP??FSPTVG?CLE

AILMEGL192703_1_2_PE12 NOISO YADRALAFYAVRDGKMSLLRRLKASRARRSSTLASPIEPFQSRLDSHFAGLFTRRLKPAF ANOCA19_5_PE8 NOISO YSEKALTFFGVKDAKMTCLQQFKVARFKK-----GHFDPFQNKINHQFPTFFSHNLKPAF BOVIN19_58_PE40 NOISO YADRALAFYAVRDGKMSLLRRLRASR-RRSGTPASPVDPFQSRLDSHFAGLFTRRLKPAF CALJA5_130_PE62 ENSCJAG00000013980 YADRALAFYAVRDGKMNLLRRLKASRTRRVGVPASPIDPFQSRLDSHFASLFTHRLKPAF CALJA5_130_PE63 ISOFORMIN YADRALAFYAVRDGKMNLLRRLKASRTRRVGVPASPIDPFQSRLDSHFASLFTHRLKPAF CALJA5_130_PE64 ISOFORMIN YADRALAFYAVRDGKMNLLRRLKASRTRRVGVPASPIDPFQSRLDSHFASLFTHRLKPAF CANFA9_8_PE36 NOISO YADRALAFYAVRDGKMNLLRRLKASRARRSSTLASSIDPFQSRLDGHFAGLFTRRLKPAF CAVPO193_1_PE14 NOISO YADRALAFYTVHDGKMSLLRRLKASRPRRSGALASPTDPFQSRLDSHFAGLFTHRLKPAF DIPORGS_2764_PE8 NOISO YADRALAFYAVRDGKLSLLRRLKASRPRRSGALASPADPFQSRLDSHFGELFNHRLKPAF FELCAGS_4086_PE15 NOISO YADRALAFYAVRDGKMNLLRRLKASRARRSSSLSSSIDPFQSRLDSHFAGLFTRRLKPAF GORGO5_8_PE32 ENSGGOG00000009236 YADRALAFYAVRDGKMSLLRRLKASRPRRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAF GORGO5_8_PE33 ISOFORMIN YADRALAFYAVRDGKMSLLRRLKASRPRRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAF HORSE11_7_PE16 NOISO YADRALAFYAVRDGKMSLLRRLKASRARRSGTPASPIDPFQSRLDSHFAGLFTRRLKPAF HS17_PE3001 NOISO YADRALAFYAVRDGKMSLLRRLKASRPRRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAF LOXAF49_7_PE30 NOISO YADRALAFYAVRDGKMNLLRRLKASRPRRSGAPALPIDPFQSRVDSHFMGLFTRRLKPAF MACEUGS_4193_PE1 NOISO YADRALAFYAVKDGKVSLLQRLRASKPRRGVPSFRLV-PFQNRLDNHFPNLFTHRLKPAF MACMU16_75_PE24 NOISO YADRALAFYAVRDGKMSLLRRLKASRPRRGGVPASPIDPFQSRLDSHFAGLFTHRLKPAF MICMUGS_1603_PE17 NOISO YADHALAFYAVRDGKVSLLRRLKASRPRRSGALASPTDPFQSRLDSHFAGLFAHRLKPAF MONDO2_220_PE17 NOISO YADRALAFYAVKEGKVSLLHKLRASKPRRGGSPSSPL-TPFQRLDSHFPNLFTHRLKPAF MOUSE11_PE4033 ISOFORMIN YADHALAFYAVRDGKLSLLRRLKASRPRRSGALASPTDPFQSRLDSHFSGLFNHRLKPAF MOUSE11_PE4034 ENSMUSG00000020773 YADHALAFYAVRDGKLSLLRRLKASRPRRSGALASPTDPFQSRLDSHFSGLFNHRLKPAF MYOLUGS_2358_PE1 NOISO YADRALAFYAVRDGKVSLLRRLKATRARRSGPPASPGDPFQSVLDSHFPGLFRSRLKPAF OCHPRGS_2043_PE1 NOISO YADRALAFYAVRDGKVSLLRRLKASRPRRSGALASPSDAFQSRLDSHFASLFSHRLKPAF ORNANCONTIG19997_PE2 ENSOANG00000012910 YADRALAFYAVRDGKVQLLRRLRASRPRR-GPPPSPLEAFQSCLDSHFGGLFSRRLKPAF ORNANCONTIG19997_PE3 ISOFORMIN YADRALAFYAVRDGKVQLLRRLRA----------SPLEAFQSCLDSHFGGLFSRRLKPAF PANTR17_80_PE23 NOISO YADRALAFYAVRDGKMSLLRRLKASRPRRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAF PIG12_4_PE30 NOISO YADRALAFYAVQDGKMSLLRRLKASRARRTGTPASPVDPFQSRLDSHFAGLFTRRLKPAF POEGU18_9_PE20 NOISO YSEKALTFYGVKDSKMTCLQQLKVSPSAK-----GKLDPFQNKINRQFASLFSCKLKPAF PONPY17_69_PE14 NOISO YADRALAFYAVRDGKMSLLRRLKASRARRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAF PTEVAGS_2976_PE26 NOISO YADRALAFYAVRDGKMTLLRRLKATRARRSGPPASPIDPFQSRLDSHFSGLFTSRLKPAF RABITUN1026_PE1 ENSOCUG00000006661 YADRALAFYAVRDGKVSLLRRLRASRLRRSGALASPADPFQSRLDSHFAGLFSHKLKPAF RABITUN1026_PE2 ISOFORMIN YADRALAFYAVRDGKVSLLRRLRASRLRRSGALASPADPFQSRLDSHFAGLFSHKLKPAF RAT10_PE2502 NOISO YADHALAFYAVREGKLSLLRRLKASRPRRSGALASPTDPFQSRLDSHFSGLFNYRLKPAF SPETRGS_1349_PE4 NOISO YADRALTFYAVRDGKMSLLRRLKASRPRRSGVPASPADPFQSRLDSHFAGLFTHRLKPAF TURTRGS_2909_PE15 NOISO YADRTLAFYAVRDGKMSLLRRLKTSRARRSGTPASPVDPFQSRLDSHFAGLFTHRLKPAF MATCH *::::*:*: *::.*: *::::. . . :: :* :* .***** CONSENSUS YADRALAFYAVRDGK??LLRRLKASR?RR?G??ASP?DPFQSRLDSHF??LF??RLKPAF

AILMEGL192703_1_2_PE12 NOISO FLESVDAHLQIGPLKKSCISVLKRR ANOCA19_5_PE8 NOISO FLESVDAHMQLGPLKKDCVSVLKRR BOVIN19_58_PE40 NOISO FLESVDAHLQIGPLKKSCISVLKRR CALJA5_130_PE62 ENSCJAG00000013980 FLESVDAHLQIGPLKKSCISVLKRR CALJA5_130_PE63 ISOFORMIN FLESVDAHLQIGPLKKSCISVLKRR CALJA5_130_PE64 ISOFORMIN FLESVDAHLQIGPLKKSCISVLKRR CANFA9_8_PE36 NOISO FLESVDAHLQIGPLKKSCISVLKRR CAVPO193_1_PE14 NOISO FLESVDAHVQIGPLKKSCITVLKRR DIPORGS_2764_PE8 NOISO FLESVDAHLQIGPLKKSCISVLKRR FELCAGS_4086_PE15 NOISO FLESVDAHLQMGPLKKSCISVLKRR GORGO5_8_PE32 ENSGGOG00000009236 FLESVDAHLQIGPLKKSCISVLKRR GORGO5_8_PE33 ISOFORMIN FLESVDAHLQIGPLKKSCISVLKRR HORSE11_7_PE16 NOISO FLESVDAHLQIGPLKKSCISVLKRR HS17_PE3001 NOISO FLESVDAHLQIGPLKKSCISVLKRR LOXAF49_7_PE30 NOISO FLESVDAHLQIGPLKKSSISVLKRR MACEUGS_4193_PE1 NOISO FLESVDAHLQIGPLKKSCISVLKRR MACMU16_75_PE24 NOISO FLESVDAHLQIGPLKKSCISVLKRR MICMUGS_1603_PE17 NOISO FLESVDAHLQIGPLKKSCISVLKRR MONDO2_220_PE17 NOISO FLESVDAHLQIGPLKKSCISVLKRR MOUSE11_PE4033 ISOFORMIN FLESVDAHLQIGPLKKSCITVLKRR MOUSE11_PE4034 ENSMUSG00000020773 FLESVDAHLQIGPLKKSCITVLKRR MYOLUGS_2358_PE1 NOISO FLESVDAHLQIGPLKKSCISVLKRR OCHPRGS_2043_PE1 NOISO FLESVDAHLQIGPLKKSCISVLKRR ORNANCONTIG19997_PE2 ENSOANG00000012910 FLESVDAHLQIGPLKKSCISVLKRR ORNANCONTIG19997_PE3 ISOFORMIN FLESVDAHLQIGPLKKSCISVLKRR PANTR17_80_PE23 NOISO FLESVDAHLQIGPLKKSCISVLKRR PIG12_4_PE30 NOISO FLESVDAHLQIGPLKKSCISVLKRR POEGU18_9_PE20 NOISO FLESVDAHLQIGPLKRDCVSVLKRR PONPY17_69_PE14 NOISO FLESVDAHLQIGPLKKSCISVLKRR PTEVAGS_2976_PE26 NOISO FLESVDAHLQIGPLKKSCISVLKRR RABITUN1026_PE1 ENSOCUG00000006661 FLESVDAHLQIGPLKKSCISVLKRR RABITUN1026_PE2 ISOFORMIN FLESVDAHLQIGPLKKSCISVLKRR RAT10_PE2502 NOISO FLESVDAHLQIGPLKKSCISVLKRR SPETRGS_1349_PE4 NOISO FLESVDAHLQIGPLKKSCISVLKRR TURTRGS_2909_PE15 NOISO FLESVDAHLQIGPLKKSCISVLKRR MATCH ********:*:****:..::***** CONSENSUS FLESVDAHLQIGPLKKSCISVLKRR


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