This phylogenetic tree is based on the alignment indicated below. Stk11/Par4 Subgroup CLUSTAL W (1.74) multiple sequence alignment STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS MDAPSTSSGAQSKLLMPGDDEADEDHQNRGDPNLQQKQKIQLNVDPDYDDDEDDDCFIDG STK11_HUMAN --------MEVVD------------PQQLGMFTEGE------------------------ STK11_MOUSE --------MDVAD------------PEPLGLFSEGE------------------------ STK11_XENOPUS --MLCPSSMDEEG------------SEEIGFLGD-------------------------- PAR4_CELEGANS CEASAPITRELVDGAIERRSKDRNVKMSIGVYDEYDDDDDDEEETEEDQRRRFVEGIRNI : . :*. : STK11_HUMAN ----------------LMSVGMDTFIHRIDSTEVIYQPRRK--------------RAKLI STK11_MOUSE ----------------LMSVGMDTFIHRIDSTEVIYQPRRK--------------RAKLI STK11_XENOPUS -----------------LSVGMDTFIHRIDSTEVIYQPRRK--------------RAKLV PAR4_CELEGANS RHKQQESFDLEEHPIPVESEAMRQFINQQVNNAMMFNQDNSEFQHIEFEPIVKQKGPKII * .* **:: .. :::: .. .*:: STK11_HUMAN GKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR STK11_MOUSE GKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR STK11_XENOPUS GKYLMGDLLGEGSYGKVKEMLDSDTLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR PAR4_CELEGANS EGYMWGGQIGTGSYGKVKECIDMYTLTRRAVKIMKYDKLRKITNGWENIRSEMSILRRMN *: *. :* ******** :* ** ******:* .***:*.** *::.*:.:***:. STK11_HUMAN HKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEY STK11_MOUSE HRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQLIDGLEY STK11_XENOPUS HRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVQDKHFPVFQAHGYFCQLIDGLEY PAR4_CELEGANS HRNVIKLIEIFNIPAKGKVYMVFEYCIGSVQQLLDMEPARRLTIGESHAIFIELCQGLNY *:***:*:::: * *:***:***: .:*::** :::.: ::*. * :* :**:* STK11_HUMAN LHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIAN STK11_MOUSE LHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIAN STK11_XENOPUS LHSQGIVHKDIKPGNLLLTTDGTLKISDLGVAEALHPFAEGDTCRTSQGSPAFQPPEIAN PAR4_CELEGANS LHSKRVSHKDIKPGNLLVSIDFTVKICDFGVAEQINLFQRDGRCTKVNGTPKFQPPECIY ***: : **********:: . *:**.*:**** :: * .. * . :*:* ***** STK11_HUMAN GL-DTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG--DCGPPLS STK11_MOUSE GL-DTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC--DCGPPLS STK11_XENOPUS GL-DTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYSIPE--ECGPLLS PAR4_CELEGANS GNHDFFDGYKADMWSAGVTLYNLVSGKYPFEKPVLLKLYECIGTEPLQMPTNVQLTKDLQ * * *.*:*.*:*********:.:* **** : **:* ** :* : *. STK11_HUMAN DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLED STK11_MOUSE DLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRSMTVVPYLED STK11_XENOPUS DLLRGMLEYDPAKRFSIQQIRQHNWFRKKHPHMDPIVPIPPSPETKDRWRSLTVVPYLED PAR4_CELEGANS DLLTKLLEKDFNERPTCLETMIHPWFLSTFPEDQGLGRIMERMRTGD--RPLTMLSSMTA *** :** : :* : : * ** ...* : * * * *.:*::. : STK11_HUMAN LHG---ADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLP--KAVCMNGTEAA STK11_MOUSE LHGRAEEEEEEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLP--KAVCVNGTEP- STK11_XENOPUS LHG---YSEEEDLCDFEDDIIYTQDFTVPGQVAEDDYFAQTQSTAPS--KQLCMNGTES- PAR4_CELEGANS LYDG---ITPEDELIIEDNLGIIQQILP-INLTSEAVLERGSFPGFKFLEAKPGDGPDGV *:. ** :**.: *:: :: .: . . . : :*.: STK11_HUMAN Q-LSTKSRAEGR--APNPARKACSASSKIRRLSACKQQ---------------------- STK11_MOUSE Q-LSSKVKPEGRPGTANPARKVCSSN-KIRRLSACKQQ---------------------- STK11_XENOPUS Q-LKTERRVSSS-----SQRKASTTGSKVRKLSACKQQ---------------------- PAR4_CELEGANS EGSEDSAAPLGP--QRRPSSRSMPTCAPPGPAAGNAQNSTAENGAETDGVASASDPPPTA : . . . . : .: :. *: STK11_HUMAN ------------------------- STK11_MOUSE ------------------------- STK11_XENOPUS ------------------------- PAR4_CELEGANS APGAPPRRRKRNFFSCIFRSRTDSA Stk11/Par4 and other related serine/threonine-protein kinases CLUSTAL W (1.74) multiple sequence alignment STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS MDAPSTSSGAQSKLLMPGDDEADEDHQNRGDPNLQQKQKIQLNVDPDYDDDEDDDCFIDG OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA ------------------------------------------------------------ T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS MSSASVGKKPEHVNTPPGDNQQKSSKENQKSNKDKQSSNQPPGQIPHSTNSGTRKSSGSG YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN ---------MEVVD------------PQQLGMFTEGE----------------------- STK11_MOUSE ---------MDVAD------------PEPLGLFSEGE----------------------- STK11_XENOPUS --ML-CPSSMDEEG------------SEEIGFLGD------------------------- PAR4_CELEGANS CEAS-APITRELVDGAIERRSKDRNVKMSIGVYDEYDDDDDDEEETEEDQRRRFVEGIRN OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA ------------------------------------------------------------ T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS LKTANLKHPARPSTESSTSSSHHQRPAQEMNGTSTPTATGGGGTSGATTTASSGAPAASS YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN -----------------LMSVGMDTFIHRIDSTEVIYQPRRK--------------RAKL STK11_MOUSE -----------------LMSVGMDTFIHRIDSTEVIYQPRRK--------------RAKL STK11_XENOPUS ------------------LSVGMDTFIHRIDSTEVIYQPRRK--------------RAKL PAR4_CELEGANS IRHKQQESFDLEEHPIPVESEAMRQFINQQVNNAMMFNQDNSEFQHIEFEPIVKQKGPKI OSK4_RICE ---------------------------------MEGNARGGG--------------HSEA OSK3_RICE ---------------------------------MDGNAKGGG--------------HSEA OSK1_RICE ---------------------------------MEGAGRDG-----------------NP W03G1.6_CELEGA -----------------------------------------------------MSKYEVL T01C8.1_CELEGA -------------------------MSSPGGETSTKQQQELK--------------AQIK PAR1_CELEGANS GGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAARRND--------------QDVH YNA3__CELEGANS -------------------------MP-PSGRFDRTIALAGT--------------GHLK STK11_HUMAN IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL STK11_MOUSE IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL STK11_XENOPUS VGKYLMGDLLGEGSYGKVKEMLDSDTLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL PAR4_CELEGANS IEGYMWGGQIGTGSYGKVKECIDMYTLTRRAVKIMKYDKLRKITNGWENIRSEMSILRRM OSK4_RICE LKNYNLGRTLGIGSFGKVKIAEHKLTGHRVAIKILNRRQMRNMEMEEK-AKREIKILRLF OSK3_RICE LKNYNLGRTLGIGSFGKVKIAEHKLTGHRVAIKILNRRQMRNMEMEEK-AKREIKILRLF OSK1_RICE LGGYRIGKTLGIGSFGKVKIAEHILTGHKVAIKILNRRKIKSMEMEEK-VKREIKILRLF W03G1.6_CELEGA QGFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLGHDLPRVQ---TEMDALRNL T01C8.1_CELEGA IGHYILKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGK-IRREIQNLSLF PAR1_CELEGANS VGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKL--FREVKIMKQL YNA3__CELEGANS IGNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNK-TRNEIDNLQKL : :* * :. *: . * *:**:. : *:. : : STK11_HUMAN RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL STK11_MOUSE RHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFRQLIDGL STK11_XENOPUS RHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVQDK-HFPVFQAHGYFCQLIDGL PAR4_CELEGANS NHRNVIKLIEIFNIPAKGKVYMVFEYCIGSVQQLLDMEPAR-RLTIGESHAIFIELCQGL OSK4_RICE IHPHIIRLYEVIYTP--TDIYVVMEYCKFG--ELFDYIVEKGRLQEDEARRIFQQIISGV OSK3_RICE IHPHIIRLYEVIYTP--TDIYVVMEYCKFG--ELFDYIVEKGRLQEDEARRIFQQIISGV OSK1_RICE MHPHIIRLYEVIDTP--ADIYVVMEYVKSG--ELFDYIVEKGRLQEEEARRFFQQIISGV W03G1.6_CELEGA SHQNICRLYHYIETE--DKFFIVMEYCSGG--EMFDYIVRKERLEESEARHFFRQLVSAI T01C8.1_CELEGA RHPHIIRLYQVISTP--SDIFMIMEHVSGG--ELFDYIVKHGRLKTAEARRFFQQIISGV PAR1_CELEGANS DHPNIVKLYQVMETE--QTLYLVLEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV YNA3__CELEGANS THPHITRLFRVISTP--SDIFLVMELVSGG--ELFSYITRKGALPIRESRRYFQQIISGV * :: :* : .::::* . :::. : : ::: * :: ..: STK11_HUMAN EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP-FAADDTCRTSQGSPAFQPPE STK11_MOUSE EYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHP-FAVDDTCRTSQGSPAFQPPE STK11_XENOPUS EYLHSQGIVHKDIKPGNLLLTTDGTLKISDLGVAEALHP-FAEGDTCRTSQGSPAFQPPE PAR4_CELEGANS NYLHSKRVSHKDIKPGNLLVSIDFTVKICDFGVAEQINL-FQRDGRCTKVNGTPKFQPPE OSK4_RICE EYCHRNMVVHRDLKPENLLLDSKYNVKLADFGLSNVMH----DGHFLKTSCGSPNYAAPE OSK3_RICE EYCHRNMVVHRDLKPENLLLDSKYNVKLADFGLSNVMH----DGHFLKTSCGSPNYAAPE OSK1_RICE EYCHRNMVVHRDLKPENLLLDSKCNVKIADFGLSNVMR----DGHFLKTSCGSPNYAAPE W03G1.6_CELEGA AFVHSQGYAHRDLKPENLLLTEDLHLKLIDFGLCAKTEKGRIDKHNLDTCCGSPAYAAPE T01C8.1_CELEGA DYCHRHMVVHRDLKPENLLLDEQNNVKIADFGLSNIMT----DGDFLRTSCGSPNYAAPE PAR1_CELEGANS QYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFS----LGNKLDTFCGSPPYAAPE YNA3__CELEGANS SYCHNHMIVHRDLKPENLLLDANKNIKIADFGLSNYMT----DGDLLSTACGSPNYAAPE : * : *:*:*. ***: :*: *:*.. . *:* : .** STK11_HUMAN IANGL-DTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG--DCGP STK11_MOUSE IANGL-DTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC--DCGP STK11_XENOPUS IANGL-DTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYSIPE--ECGP PAR4_CELEGANS CIYGNHDFFDGYKADMWSAGVTLYNLVSGKYPFEKPVLLKLYECIGTEPLQMPTNVQLTK OSK4_RICE VISG--KLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPS--HLSA OSK3_RICE VISG--KLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPS--HLSA OSK1_RICE VISG--KLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPS--HLSP W03G1.6_CELEGA LIQG--LQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPE--FLSP T01C8.1_CELEGA VISG--KLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPSLFRKIKSGVFPTPD--FLER PAR1_CELEGANS LFSG--KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF--YMST YNA3__CELEGANS LISN--KLYVGPEVDLWSCGVILYAMLCGTLPFDDQNVPTLFAKIKSGRYTVPY--SMEK . : * :.*:** *: ** : * **: : : : * STK11_HUMAN PLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVP----IPPSPDTKDRWRSMT STK11_MOUSE PLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVP----IPPSPDTKDRWRSMT STK11_XENOPUS LLSDLLRGMLEYDPAKRFSIQQIRQHNWFRKKHPHMDPIVP----IPPSPETKDRWRSLT PAR4_CELEGANS DLQDLLTKLLEKDFNERPTCLETMIHPWFLSTFPEDQGLGR----IMERMRTGD--RPLT OSK4_RICE LARDLIPRMLVVDPMKRITIREIREHQWFQIRLPRYLAVPPPDTAQQAKMIDEDTLQDVV OSK3_RICE LARDLIPRMLVVDPMKRITIREIREHQWFQIRLPRYLAVPPPDTAQQAKMIDEDTLQDVV OSK1_RICE LARDLIPRMLVVDPMKRITIREIREHQWFTVGLPRYLAVPPPDTAQQVKKLDDETLNDVI W03G1.6_CELEGA LSKQLLRAMLQVVPERRISVKKLLEHDWLNHKYTQPVKWNT---IYDKNFIDRDVARVMS T01C8.1_CELEGA PIVNLLHHMLCVDPMKRATIKDVIAHEWFQKDLPNYLFPP--INESEASIVDIEAVREVT PAR1_CELEGANS DCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIE--PPKDQIDEQRIEKLI YNA3__CELEGANS QAADLISTMLQVDPVKRADVKRIVNHSWFRIDLPYYLFP---ECENESSIVDIDVVQSVA :*: :* .* . *: : . : STK11_HUMAN VVP-------------------YLEDLHG---ADEDEDLFDIEDDIIYTQDFTVP--GQV STK11_MOUSE VVP-------------------YLEDLHGRAEEEEEEDLFDIEDGIIYTQDFTVP--GQV STK11_XENOPUS VVP-------------------YLEDLHG---YSEEEDLCDFEDDIIYTQDFTVP--GQV PAR4_CELEGANS MLS-------------------SMTALYDG---ITPEDELIIEDNLGIIQQILP---INL OSK4_RICE NLG------------------YEKDHVCESLR-NRLQNEATVAYYLLLDNRFRA--TSGY OSK3_RICE NLG------------------YGKDHVCESLR-NRLQNEATVAYYLLLDNRFRA--TSGY OSK1_RICE NMG------------------FDKNQLIESLH-KRLQNEATVAYYLLLDNRLRT--TSGY W03G1.6_CELEGA KYYG-----------------FESTDKMIEKIKEWNFDYMTSTYYALLHRKRNGMEIILP T01C8.1_CELEGA ER-----------------YHVAEEEVTSALLGDDPHHHLSIAYNLIVDNKRIADETAKL PAR1_CELEGANS QIFQLG-----------FNKAAILESVEKEKFEDIHATYLLLGERKSDMDASEITMAQSL YNA3__CELEGANS EKTPPEKIIYFFIFRHFLKFDVKEEDVTGALLAEDHHHFLCIAYRLEVNHKRNADESSQK STK11_HUMAN PEEEASHNGQRRGLP------------------------------KAVCMNGTEAAQ-LS STK11_MOUSE LEEEVGQNGQSHSLP------------------------------KAVCVNGTEP-Q-LS STK11_XENOPUS AEDDYFAQTQSTAPS------------------------------KQLCMNGTES-Q-LK PAR4_CELEGANS TSEAVLERGSFPGFK----------------------------FLEAKPGDGPDGVEGSE OSK4_RICE LGADYQESLERNLNR------------FASSESASSNTRHYLPGSSDPHASGLRPHY-PV OSK3_RICE LGADYQESLERNFNR------------FASSESASSNTRHYLPGSSDPHASGLRPHY-PV OSK1_RICE LGAEFHESMESSLAQ------------VTPAETPNSATDHRQHGHMESPGFGLRHHF-AA W03G1.6_CELEGA MVRNSTNTAPPNVQN-------ILCSPTIHASLENNLDKSGLEDDDSDPSSISSSSDISA T01C8.1_CELEGA SIEEFYQVTPNKGPG----PV-----HRHPERIAASVSSKITPTLDNTEASGANRN---K PAR1_CELEGANS LSHSSINVSSSLGQHPAGVITREHVTSSSASGSSASPSRYSRSSATATGASITAGSALAS YNA3__CELEGANS AMEDFWEIGKTMKMGSTSLPVGATTKSEKSERNVAKVVGKFSANVGRKILEGLKKEQ--K STK11_HUMAN TKSRAEGR--APNPARKACSASSKIRRLSACKQQ-------------------------- STK11_MOUSE SKVKPEGRPGTANPARKVCSSN-KIRRLSACKQQ-------------------------- STK11_XENOPUS TERRVSSS-----SQRKASTTGSKVRKLSACKQQ-------------------------- PAR4_CELEGANS DSAAPLGP--QRRPSSRSMPTCAPPGPAAGNAQNSTAEN--GAETDGVASASDPPPTAAP OSK4_RICE ERKWALGLQSRAQPREIMIEVLKALEDLNVCWKKNGQYNMKCRWSVGYPQATDMLDVN-- OSK3_RICE ERKWALGLQSRAQPREIMIEVLKALQDLNVSWKKNGQYNMKCRWSVG-TQATDMLDVN-- OSK1_RICE DRKWALGLQSRAHPREIITEVLKALQELNVCWKKIGHYNMKCRWSPSFPSHESMMHNN-- W03G1.6_CELEGA RLKKNCVVSDESSSSRFVKPMSPAAEKDKKMSYVNAMLTMPSQFTGRSPLRIPESPMSVR T01C8.1_CELEGA RAKWHLGIRSQSRPEDIMFEVFRAMKQLDMEWKVLNPYHVIVRRKPD-APAADPPKMSLQ PAR1_CELEGANS AANAQKHQQSSAAPSSGSSSSRRSSQNDAAATAAGGTVVMSGTRHGGVQMRAQPTSRQAT YNA3__CELEGANS KLTWNLGIRACLDPVETMKHVFLSLKSVDMEWKVLSMYHIIVRSKPT-PINPDPVKVSLQ . STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------GAPPRRRKRNFFSCIFRSRTDSA------------------- OSK4_RICE -----------------HSFVDDSIIMDNGDVNGRLPAVIK------------------- OSK3_RICE -----------------NSFVDDSIIMDNGDVNGRLPAVIK------------------- OSK1_RICE -----------------HGFGAESAIIETDDSE-KSTHTVK------------------- W03G1.6_CELEGA SSDSASLG-SAATPSRGGVKDNDKENASTGKNYRMGASTCKSRGPLKITGVGKAENVTIK T01C8.1_CELEGA LYQVDQRS----YLLDFKSLA-DEESGSASASSSRHASMS----------------MPQK PAR1_CELEGANS ISLLQPPSYKPSSNTTQIAQIPPLFNRNSTATSSAAQPSTGITG----TRKIADPKGRIP YNA3__CELEGANS LFALDKKENNKGYLLDFKGLTEDEEAVPPSRCRSRAASVSVTLAKSKSDLNGNSSKVPMS STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE -----------------------------FEIQLYKSRDEKYLLDMQRVTGPQL------ OSK3_RICE -----------------------------FEIQLYKTRDEKYLLDMQRVTGPQL------ OSK1_RICE -----------------------------FEIQLYKTRDEKYLLDLQRVSGPQL------ W03G1.6_CELEGA TQYLTLKISRNENYKEGTMKSVYTTPNTRPTLRGLFSPGNAEHKKRQRARSSDRASIGMP T01C8.1_CELEGA PAGIRG--TRTSSMPQA----------MSMEASIEKMEVHDFSDMSCDVTPPPS-PGGAK PAR1_CELEGANS LNSTAVQGHRTATGAVAANNGGIPSHRDHAQQQQYMNQLTSSTMMSKLINKTPAAGGTAA YNA3__CELEGANS PLSPMSPISPSVNIPKVRVDDADASLKSSLNSSIYMADIENSMESLDEVSTQSSEPEAPI STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE -----LFLDFCAAFLTKLRVL--------------------------------------- OSK3_RICE -----LFLDFCADFLTKLRVL--------------------------------------- OSK1_RICE -----LFLDLCSAFLTQLRVL--------------------------------------- W03G1.6_CELEGA PGSPVSIGSAHSANNADGRTPRSRIKTNRLPQRVFTSLERKKEKLITLLTPRKMQRDSPQ T01C8.1_CELEGA LSQTMQFFEICAALIGTLAR---------------------------------------- PAR1_CELEGANS TSSSSSSSATSTAPLQKSGSQISHAPTEPVIREDDDENNSENQNGNVPLIGGVGPQTSPA YNA3__CELEGANS RSQTMEFFATCHIIMQALLAE--------------------------------------- STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA VLKDVKNMVNVSMTASQDPEEVRNLLKKVFDDERMRYELNGWKFLATQETVHGWMTVELE T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS VQVPTEDATSSSDKEQQQQKASSETPKESKPSMIHQSPSMPPSQMMTAMESLKLSESGQT YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA IVRLQMFDKVGIRRKRLKGDAFMYKKVCEKILQMAKIE---------------------- T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS GGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQ YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA ------------------------------------------------------------ T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS YHPKAPSSSSSSSTNPPHQHQLTHNASFSVTPSSYQIPTSTAVNVTSTGMPTSSSSSAFP YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA ------------------------------------------------------------ T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS RNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSKLTRRD YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA ------------------------------------------------------------ T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS HNRESMTQPVSGRAGTIGASQGQQTAAALAAIREQSGPIAPGAGQVAPSLPIHEGDVKPR YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN ------------------------------------------------------------ STK11_MOUSE ------------------------------------------------------------ STK11_XENOPUS ------------------------------------------------------------ PAR4_CELEGANS ------------------------------------------------------------ OSK4_RICE ------------------------------------------------------------ OSK3_RICE ------------------------------------------------------------ OSK1_RICE ------------------------------------------------------------ W03G1.6_CELEGA ------------------------------------------------------------ T01C8.1_CELEGA ------------------------------------------------------------ PAR1_CELEGANS SLRFTWSMKTTSSLAPDDMMREIRKVLDANGCDYEQRERYMILCVYGDPNTDSLVQWEME YNA3__CELEGANS ------------------------------------------------------------ STK11_HUMAN ------------------------------------- STK11_MOUSE ------------------------------------- STK11_XENOPUS ------------------------------------- PAR4_CELEGANS ------------------------------------- OSK4_RICE ------------------------------------- OSK3_RICE ------------------------------------- OSK1_RICE ------------------------------------- W03G1.6_CELEGA ------------------------------------- T01C8.1_CELEGA ------------------------------------- PAR1_CELEGANS VCKLPRLSLNGVRFKRISGTSIGFKNIASKIAQELNL YNA3__CELEGANS -------------------------------------
Laurent Duret
Laboratoire de Biométrie, Génétique et Biologie des Populations.
UMR CNRS 5558
Université Claude Bernard - Lyon 1
43, bd. du 11 Novembre 1918
69622 Villeurbanne Cedex
France
Tel: +33 (0) 4 72 44 62 97
Fax: +33 (0) 4 78 89 27 19
E-mail:duret@biomserv.univ-lyon1.fr
January 5, 2000
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