Phylogenetic tree of the NRAMP gene family (all kingdoms)
NRAMP related, Eubacteria.
Y1BI_MYCTU HYPOTHETICAL 45.0 KD PROTEIN CY21C12.18C. MYCOBACTERIUM TUBERCULOSIS
BCG40_MYCLE HYPOTHETICAL 40.0 KD PROTEIN BCG. MYCOBACTERIUM LEPRAE
YFEP_ECOLI HYPOTHETICAL 44.2 KD PROTEIN. ESCHERICHIA COLI
NRAMP related, Fungi.
YLR034C_YEAST CHROMOSOME XII READING FRAME ORF YLR034C. SACCHAROMYCES CEREVISIAE
SMF2_YEAST TRANSPORTER PROTEIN SMF2. SACCHAROMYCES CEREVISIAE
SMF1_YEAST TRANSPORTER PROTEIN SMF1/ESP1. SACCHAROMYCES CEREVISIAE
YAV8_SCHPO HYPOTHETICAL 57.6 KD PROTEIN C27F1.08. SCHIZOSACCHAROMYCES POMBE (FISSION YEAST)
NRAMP related, Plants.
O22192_ARATH PUTATIVE METAL ION TRANSPORTER (NRAMP). ARABIDOPSIS THALIANA
O24209_ORYZA INTEGRAL MEMBRANE PROTEIN. ORYZA SATIVA (RICE).
NRAMP related, Invertebrates.
Q21433_CAEEL K11G12.3. CAENORHABDITIS ELEGANS
Q21434_CAEEL K11G12.4. CAENORHABDITIS ELEGANS
seqcel : your sequence. CAENORHABDITIS ELEGANS
MVL_DROME MALVOLIO PROTEIN. DROSOPHILA MELANOGASTER
NRAMP1, vertebrates
NRM1_CHICK NRAMP1. CHICKEN
NRM1_HUMAN NRAMP1. HUMAN
NRM1_MOUSE NRAMP1. MOUSE
NRAM_CEREL NRAMP1. CERVUS ELAPHUS (RED DEER)
NRM1_BISBI NRAMP1. BISON BISON (AMERICAN BISON)
NRM1_BOVIN NRAMP1. BOS TAURUS (BOVINE)
NRM1_BUBAR NRAMP1. BUBALUS ARNEE BUBALIS (DOMESTIC WATER BUFFALO)
NRAMP2, vertebrates
NRM2_HUMAN NRAMP2. HUMAN
O35172_RAT NRAMP2. RAT
NRM2_MOUSE NRAMP2. MOUSE
Alignment:
CLUSTAL W(1.60) multiple sequence alignment
O22192_ARATH ----------------MPQLENNEPLLINEEEEEETAYDET---------------EKVH
O24209_ORYZA ------------------------------------------------------------
Q21433_CAEEL ------------------------------------------------------------
seqcel ------------------------------------------------------------
Q21434_CAEEL -----------------MASSNNDGPIEPEAEPWRITQNDH-------------LEQDLL
MVL_DROME --------MSSNEAYHEPGAGGDGPGGSSGASGGGSQRS------------NQLHHQQIL
NRAM_CEREL --------MPGD-----MGPPKQGGTR---YGSISSPPSPG--------------PQQAP
NRM1_BISBI --------MSGD-----TGPPKQGGTR---YGSISSPPSPE--------------PQQAP
NRM1_BOVIN --------MSGD-----TGPPKQGGTR---YGSISSPPSPE--------------PQQAP
NRM1_BUBAR --------MSGD-----TGPSKQGGTR---YGSISSPPSPG--------------PQQAP
NRM1_HUMAN --------MTGD-----KGPQRLSGSS---YGSISSPTSPTSPG-----------PQQAP
NRM1_MOUSE --------MISD-----KSPPRLSRPS---YGSISSLPGPA--------------PQPAP
NRM1_CHICK --------MSGSGPAMASLEPGLAGSLNRGQTDASNVPVPP--------------HHPVP
NRM2_HUMAN ------------------------------------------------------------
O35172_RAT MVLDPEEKIPDDGASGDHGDSASLGAINPAYSNSSLPHSTG---------------DSEE
NRM2_MOUSE MVLDPKEKMPDDGASGDHGDSASLGAINPAYSNSSLPHSTG---------------DSEE
SMF1_YEAST ---------------MVNVGPSHAAVAVDASEARKRNISEEVFELRDKKDSTVVIEGEAP
SMF2_YEAST --------------------MTSQEYEPIQWSDESQTNNDS------------VNDAYAD
YAV8_SCHPO ----------------MSSQSYYMNDLDDLRSLESSTLNKK----------DTAINELNP
YLR034C_YEAST ------------------------------------------------------------
BCG40_MYCLE ------------------------------------------------------------
Y1BI_MYCTU ------------------------------------------------------MAGEFR
YFEP_ECOLI ------------------------------------------------------------
O22192_ARATH IVRNEEE----------DDLEHGVGCGGAPPFSWKKLWLFTGPGFLMSIAFLDPGNLEGD
O24209_ORYZA ---------------------------MRPAFSWRKLWRFTGPGFLMCIAFLDPGNLEGD
Q21433_CAEEL ----------------------------------------------MSIAYLDPGNIESD
seqcel ------------------------------TFSWRKLWAFTGPGFLMSIAYLDPGNIESD
Q21434_CAEEL EEDAESQ----------ERVDIPVDD-VEKAFSFKKLWAFTGPGFLMSIAYLDPGNIESD
MVL_DROME NETTYLKPAAKQAYFSDEKVLIPDDDSTNVGFSFRKLWAFTGPGFLMSIAYLDPGNIESD
NRAM_CEREL PGGTYLS----------EKIPIPDTE--SGAFSLRKLWAFTGPGFLMSIAFLDPGNIESD
NRM1_BISBI PGGTYLS----------EKIPIPDTE--SGTFSLRKLWAFTGPGFLMSIAFLDPGNIESD
NRM1_BOVIN PGGTYLS----------EKIPIPDTE--SGTFSLRKLWAFTGPGFLMSIAFLDPGNIESD
NRM1_BUBAR PGGTYLG----------EKIPIPDTE--SGAFSLRKLWAFTGPGFLMSIAFLDPGNIESD
NRM1_HUMAN PRETYLS----------EKIPIPDTK--PGTFSLRKLWAFTGPGFLMSIAFLDPGNIESD
NRM1_MOUSE CRETYLS----------EKIPIPSAD--QGTFSLRKLWAFTGPGFLMSIAFLDPGNIESD
NRM1_CHICK HAQTYLD----------ELISIPKGS--TPGFSFRKLWAFTGPGFLMSIAYLDPGNVESD
NRM2_HUMAN ----------------------GMEE--YSCFSFRKLWAFTGPGFLMTIAYLDPGNIESD
O35172_RAT PFTTYFD----------EKIPIPEEE--YSCFSFRKLWAFTGPGFLMSIAYLDPGNIESD
NRM2_MOUSE PFTTYFD----------EKIPIPEEE--YSCFSFRKLWAFTGPGFLMSIAYLDPGNIESD
SMF1_YEAST VRTFTSS----SS--NHEREDTYVSKRQVMRDIFAKYLKFIGPGLMVSVAYIDPGNYSTA
SMF2_YEAST VNTTHES--------RRRTTLQPNSTSQSMIGTLRKYARFIGPGLMVSVSYMDPGNYSTA
YAV8_SCHPO EQNDTRRSTDLLLEDKYGIQTGFSKYWKKCTYGIREYCKFIGPGFLIAVAYIDPGNYSTD
YLR034C_YEAST --------------------------MRSYMQILQKFAKFIGPGILVSVAYMDPGNYATS
BCG40_MYCLE --------------------------------------------------------MAAN
Y1BI_MYCTU LLSHLCS----------RGSKVGELAQ-DTRTSLKTSWYLLGPAFVAAIAYVDPGNVAAN
YFEP_ECOLI -----MT----------NYRVESSSG----RAARKMRLALMGPAFIAAIGYIDPGNFATN
O22192_ARATH LQAGAVAGYSLLWLLMWATAMGLLVQLLSARLGVATGRHLAELCRDEYPTWARMVLWVMA
O24209_ORYZA LQAGAAAGYQLLWLLLWATVMGALVQLLSARLGVATGKHLAELCREEYPPWATAALWAMT
Q21433_CAEEL LQAGAQAEYKLLWVLLVSHIVGMLLQRMSARLGVVSGKHMAEIAYDYYPLVPRIILWLMI
seqcel LQAGAISYFKLIWVLLVAHIMGLLLQRLAARLGVVSGKHMAEIAFSYYPKIPRLVLWMLV
Q21434_CAEEL LQSGAQAAYKLLWVLLSAHIIGMLLQRMSARLGVVSGKHMAEVAYQFYPRLPRIILWLMI
MVL_DROME MQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVTGLHLAEMCYRQYKRLPRWILWIMI
NRAM_CEREL LQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTI
NRM1_BISBI LQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTI
NRM1_BOVIN LQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTI
NRM1_BUBAR LQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTI
NRM1_HUMAN LQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTI
NRM1_MOUSE LQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTI
NRM1_CHICK LQCGAVAGFKLLWVLLWATVLGLLCQRLAIRLGVVTGKDLAEICYLYYPRVPRVLLWLMM
NRM2_HUMAN LQSGAVAGFKLLWILLLATLVGLLLQRLAAKLGVVTGLHLAEVCHRQYPKVPRVILWLMV
O35172_RAT LQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMV
NRM2_MOUSE LQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMV
SMF1_YEAST VDAGASNQFSLLCIILLSNFIAIFLQCLCIKLGSVTGLDLSRACREYLPRWLNWTLYFFA
SMF2_YEAST VAAGSAHRYKLLFSVLVSNFMAAFWQYLCARLGAVTGLDLAQNCKKHLPFGLNITLYILA
YAV8_SCHPO LDAGSRFQYKLLFIVFLSNLFAVYLQSLCIRLGSVTGMDLARNCREHYNRYICWSFYVLA
YLR034C_YEAST VSGGAQYKYTLLFSIFISNIFAVLLQCLCVKLGTITGYDLAENCRHNLPKKLNYTLYLFA
BCG40_MYCLE VSSGAQFGYLQLWVVVVANVLAGLVQYLSAKLGLVTGQSLPQAISKQMSHPFRLGFWLQA
Y1BI_MYCTU VSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQA
YFEP_ECOLI IQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQA
. *. . . . . * .. .** .* .
O22192_ARATH ELALIGSDIQEVIGSAIAIKILSNGILPLWAGVVITALDCFVFLFLE------NYGIRKL
O24209_ORYZA ELALVGADIQEVIGSAIAIKILSAGTVPLWGGVVITAFDCFIFLFLE------NYGVRKL
Q21433_CAEEL EIAIVCSDMQEVIGTAIAIYLLSSGKIPLLVGVLITILDTFTFLFID------RYGIRKL
seqcel ESAIVGSDMQEVIGTAISFYLLSNGRIPLWAGVLITICDTFTFLFLE------KYGVRKF
Q21434_CAEEL EIAIVCSDMQEVIGTAIAIFLLSKGFVPLYVGVFITILDTFTFLLID------RYGIRKL
MVL_DROME EIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTFTFLFLD------KYGLRKL
NRAM_CEREL ELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITIVDTFFFLFLD------NYGLRKL
NRM1_BISBI ELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITIVDAFFFLFLD------NYGLRKL
NRM1_BOVIN ELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITVVDTFFFLFLD------NYGLRKL
NRM1_BUBAR ELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITVVDTFFFLFLD------NYGLRKL
NRM1_HUMAN ELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLD------NYGLRKL
NRM1_MOUSE ELAIVGSDMQEVIGTAISFNLLSAGRIPLWGGVLITIVDTFFFLFLD------NYGLRKL
NRM1_CHICK EIAIIGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITITDTLFFLFLD------KYGLRKL
NRM2_HUMAN ELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLD------KYGLRKL
O35172_RAT ELAIIGSDMQEVIGSAIAINLLSAGRVPLYGGVLITIADTFVFLFLD------KYGLRKL
NRM2_MOUSE ELAIIGSDMQEVIGSAIAINLLSAGRVPVWGGVLITIADTFVFLFLD------KYGLRKL
SMF1_YEAST ECAVIATDIAEVIGTAIALNILI--KVPLPAGVAITVVDVFLIMFTYKPGASSIRFIRIF
SMF2_YEAST EMAIIATDLAEVVGTAISLNILF--HIPLALGVILTVVDVLIVLLAYKPNG-SMKGIRIF
YAV8_SCHPO EIAIIATDIAEVIGTAVALKILM--HIPLVAGVVITILDVLLVLIAWRPEG-SMLSVRIF
YLR034C_YEAST EVAIIATDLAEVVGTAIALQILF--KIPLTWGVLLTVLDVLVILMFYTPNGQSLKKVRVF
BCG40_MYCLE ELVAMATDVAEIVGGAIAFHILF--RVSLLLGGVITGTVSLLLLMVKD-----RRGQLLF
Y1BI_MYCTU EIVAMATDVAEVIGGAIALRIMF--NLPLPIGGIITGVVSLLLLTIQD-----RRGQRLF
YFEP_ECOLI EIIAMATDLAEFIGAAIGFKLIL--GVSLLQGAVLTGIATFLILMLQ------RRGQKPL
* . .*. * .* *. .. . . * .* .
O22192_ARATH EAVFAVLIATMGVSFAWMFGQAKPSG-SELLIGILVPKLSSR----TIQKAVGVVGCIIM
O24209_ORYZA EAFFGVLIAVMAVSFAIMFGETKPSG-KDLLIGLVVPKLSSR----TIKQAVGIVGCIIM
Q21433_CAEEL EFIFVALISTMAISFGYEFVVMKPVL-TKVLTGTVVPWCSGCG-KEEIITAISIFGAVIM
seqcel EAFFCFLITCMAITFGYEFGVSAPDK-GKMFSGMFVPWCNGCD-NNMVMQGVAIIGAVIM
Q21434_CAEEL ELIFGFLILTMTVSFGYEFVVVKPPI-GEVISGMVVPWCAGCG-KGEFMQAISVVGAVIM
MVL_DROME EFLFGTLITIMAVSFGYEYIVSAPNQ-GEVLEGMFVPWCSNCN-SNVLLQAVGVVGAVIM
NRAM_CEREL EAFFGFLITIMALTFGYEYVVARPAQ-GALLQGLFLPSCAGCG-QPELLQAVGIVGAIIM
NRM1_BISBI EAFFGFLITIMALTFGYEYVVAQPAQ-GALLQGLFLPSCPGCG-QPELLQAVGIIGAIIM
NRM1_BOVIN EAFFGFLITIMALTFGYEYVVAQPAQ-GALLQGLFLPSCPGCG-QPELLQAVGIIGAIIM
NRM1_BUBAR EAFFGFLITIMALTFGYEYVVAQPAQ-GALLQGLFLPSCRGCG-QPELLQAVGIIGAIIM
NRM1_HUMAN EAFFGLLITIMALTFGYEYVVARPEQ-GALLRGLFLPSCPGCG-HPELLQAVGIVGAIIM
NRM1_MOUSE EAFFGLLITIMALTFGYEYVVAHPSQ-GALLKGLVLPTCPGCG-QPELLQAVGIVGAIIM
NRM1_CHICK EAFFGFLITIMALTFGYEYVMVRPAQ-TEVLKGIFLPYCPGCG-REELLQAVGIVGAIIM
NRM2_HUMAN EAFFGFLITIMALTFGYEYVTVKPSQ-SQVLKGMFVPSCSGCR-TPQIEQAVGIVGAVIM
O35172_RAT EAFFGFLITIMALTFGYEYVTVKPSQ-SQVLRGMFVPSCSGCH-TPQVEQAVGIVGAVIM
NRM2_MOUSE EAFFGFLITIMALTFGYEYITVKPSQ-SQVLRGMFVPSCPGCR-TPQVEQAVGIVGAVIM
SMF1_YEAST ECFVAVLVVGVCICFAIELAYIPKSTSVKQVFRGFVPSAQMFD-HNGIYTAISILGATVM
SMF2_YEAST EAFVSLLVVLTVVCFTVELFYAKLGP-AKEIFSGFLPSKAVFE-GDGLYLSLAILGATVM
YAV8_SCHPO ETAVALLVLVVAISFAVVLGRVHIGG-AGTVFKGFLPSSTVFS-REGLYSSIGILGATVM
YLR034C_YEAST EFGVGILVIGTCICFVLELFKVSIPD-KAELFKGFLPSNIIFKEQQALYISLGILGATVM
BCG40_MYCLE ERVITGLLFVIVVGFTSSFFVATPS--PEDMVNGLLPRFQGT---ESVLLAAAIIGATVM
Y1BI_MYCTU ERVITALLLVIAIGFTASFFVVTPP--PNAVLGGLAPRFQGT---ESVLLAAAIMGATVM
YFEP_ECOLI EKVIGGLLLFVAAAYIVELIFSQPNL-AQLGKGMVIPSLPTS---EAVFLAAGVLGATIM
* *. . * . *. .*
O22192_ARATH PHNVFLHSALVQSREVDKRQKY-----------------------RVQEALNYYTIESTI
O24209_ORYZA PHNVFLHSALVESRKIDTNKKS-----------------------RVQEAVFYYNIESIL
Q21433_CAEEL PHNFYLHSALVKSRKVDRSSKT-----------------------RIAEANKYFSIESAF
seqcel PHNFYLHSALVK--------------------------------------NKYFFIESAF
Q21434_CAEEL PHNLYLHSALVKSRRVDRKDRR-----------------------RVAEANKYFTLESAI
MVL_DROME PHNLYLHSALVKSRDIDRRQTK-----------------------KVSEANFYFFIEASV
NRAM_CEREL PHNIYLHSSLVKSREVDRSRRA-----------------------DIREANMYFLIEATI
NRM1_BISBI PHNIYLHSSLVKSREVDRSRRA-----------------------DIREANMYFLIEATI
NRM1_BOVIN PHNIYLHSSLVKSREVDRSRRA-----------------------DIREANMYFLIEATI
NRM1_BUBAR PHNIYLHSSLVKSREVDRSRRA-----------------------DIREANMYFLIEATI
NRM1_HUMAN PHNIYLHSALVKSREIDRARRA-----------------------DIREANMYFLIEATI
NRM1_MOUSE PHNIYLHSALVKSREVDRTRRV-----------------------DVREANMYFLIEATI
NRM1_CHICK PHNIFLHSSLVKTRAIDRSKKE-----------------------EVKEANMYFLTESCL
NRM2_HUMAN PHNMYLHSALVKSRQVNRNNKQ-----------------------EVREANKYFFIESCI
O35172_RAT PHNMYLHSALVKSRQVNRANKQ-----------------------EVREANKYFFIESCI
NRM2_MOUSE PHNMYLHSALVKSRQVNRANKQ-----------------------EVREANKYFFIESCI
SMF1_YEAST PHSLFLGSALVQPRLLDYDVKHGNYTVSEEQDKVKKSKSTEEIMEEKYFNYRPTNAAIKY
SMF2_YEAST PHSLYLGSGVVQPRLREYDIKNGHYLPDAND------------MDNNHDNYRPSYEAISE
YAV8_SCHPO PHSLFLGSGLVQTRLRDLDVRRGN-----------------YTPVGDCSDYRPTHETIKH
YLR034C_YEAST PHSLYLGSSIVKPRLHDYDLKK-----------------------YGKVNARPSLSAIKY
BCG40_MYCLE PHAVYLHSGLALDRHGHPHAGR-----------------------SRRRLLRVTRLDVIL
Y1BI_MYCTU PHAVYLHSGLARDRHGHPDPGP-----------------------QRRRLLRVTRWDVGL
YFEP_ECOLI PHVIYLHSSLTQHLHGG-SRQQ-----------------------R----YSATKWDVAI
** .* * .
O22192_ARATH ALFIS---FLINLFVTTVFAKGFYNTDL----------------------------ANSI
O24209_ORYZA ALVVS---FFINICVTTVFAKGFYGSEQ----------------------------ADGI
Q21433_CAEEL ALSVS---FFINLFVLSVFARGLYQKTNGDV-----------------------------
seqcel ALFVS---FIINTLVISVFAQGMYGKTNQ------HNGMPDFYKVEFPANND----AAQS
Q21434_CAEEL ALFLS---FFINLFVVAVFAHGLYQKTNADVREMCIARHDIPDADIFPNNTE--------
MVL_DROME ALFVS---FIINLFVVAVFAHGMYGKTNNDVVEVCKDKSMYEDAKMSFVDNVNGTAIIDA
NRAM_CEREL ALSVS---FLINLFVMAVFGQAFYKQTNQAAFNICANSSLHDYATIFPRNNL----TVAV
NRM1_BISBI ALSVS---FLINLFVMAVFGQAFYKQTNQAAFNICANSSLQDYAPIFPRNNL----TVAV
NRM1_BOVIN ALSVS---FLINLFVMAVFGQAFYKQTNQAAFNICADSSLHDYAPIFPRNNL----TVAV
NRM1_BUBAR ALSVS---FLINLFVMAVFGQAFYKQTNQAAFNICAKSSLHDYAPIFPRNNL----TVAV
NRM1_HUMAN ALSVS---FIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNA----TVAV
NRM1_MOUSE ALSVS---FIINLFVMAVFGQAFYQQTNEEAFNICANSSLQNYAKIFPRDNN----TVSV
NRM1_CHICK ALFVS---FLINLFVMAVFGEAFYHQRNEDVHNKCVNSSVSRYASIFPINNE----TVSV
NRM2_HUMAN ALFVS---FIINVFVVSVFAEAFFGKTNEQVVEVCTNTS-SPHAGLFPKDNS----TLAV
O35172_RAT ALFVS---FIINVFVVSVFAEAFFEKTNEQVVEVCRNSS-SPHADLFPNDNS----TLAV
NRM2_MOUSE ALFVS---FIINVFVVSVFAEAFFEKTNKQVVEVCKNNS-SPHADLFPSDNS----TLAV
SMF1_YEAST CMKYSMVELSITLFTLALFVNCAILVVAGSTLYNSPE-------------------ADGA
SMF2_YEAST TLHFTITELLISLFTVALFVNCAILIVSGATLYGSTQN------------------AEEA
YAV8_SCHPO SLTYSIVEVALSLFTFALFTNSSILIVAGAVFYNTSG-------------------ADTS
YLR034C_YEAST TLNYAYAELIISLFLIATFVNSAILIVAGATLSGQPE-------------------AEDA
BCG40_MYCLE AMTIA---GIVNTAMLLVAAINLQHHQVT------------------------------A
Y1BI_MYCTU AMLIA---GGVNAAMLLVAALNMRGRGD------------------------------TA
YFEP_ECOLI AMTIA---GFVNLAMMATAAAAFHFSGHTG----------------------------VA
.. . .
O22192_ARATH GLVNAGQYLQEKYGGGVFPILYIWAIGLLAAGQSSTITGTYAGQFIMG--GFLNFKMKKW
O24209_ORYZA GLENAGQYLQQKYGTAFFPILYIWAIGLLASGQSSTITGTYAGQFVMG--GFLNLRLKKW
Q21433_CAEEL ----GGIYLGCQFG---LFAMIIWAIGIFAAGQSSTMTGTYTGQFVME--GFVRISWPKW
seqcel DIYHAGIFLGCTFG---IFALYVWAVGILAAGQSSTMTGTYAGQFAMEVQGFIQIKLPQW
Q21434_CAEEL PVE-GGIYLGCQFG---AIAMFIWGIGIFAAGQSSTMTGTYTGQFVME--GFVKIEWPKW
MVL_DROME DLYKGGLFLGCTFG---AVAMYIWGVGILAAGQSSTMTGTYAGQFSME--GFLNLQWPRW
NRAM_CEREL DIYQGGVILGCLFG---PAALYIWAVGLLAAGQSSTMTGTYAGQFVME--GFLKLRWSRF
NRM1_BISBI DIYQGGVILGCLFG---PAALYIWAVGLLAAGQSSTMTGTYAGQFVME--GFLKLRWSRF
NRM1_BOVIN DIYQGGVILGCLFG---PPALYIWAVGLLAAGQSSTMTGTYAGQFVME--GFLKLRWSRF
NRM1_BUBAR DIYQGGVILGCLFG---PAALYIWAVGLLAAGQSSTMTGTYAGQFVME--GFLKLRWSRF
NRM1_HUMAN DIYQGGVILGCLFG---PAALYIWAIGLLAAGQSSTMTGTYAGQFVME--GFLRLRWSRF
NRM1_MOUSE DIYQGGVILGCLFG---PAALYIWAVGLLAAGQSSTMTGTYAGQFVME--GFLKLRWSRF
NRM1_CHICK DIYQGGVILGCYFG---AAALYIWAVGILAAGQSSTMTGTYAGQFVME--GFLQLRWSRF
NRM2_HUMAN DIYKGGVVLGCYFG---PAALYIWAVGILAAGQSSTMTGTYSGQFVME--GFLNLKWSRF
O35172_RAT DIYKGGVVLGCYFG---PAALYIWAVGILAAGQSSTMTGTYSGQFVME--GFLNLKWSRF
NRM2_MOUSE DIYKGGVVLGCYFG---PAALYIWAVGILAAGQSSTMTGTYSGQFVME--GFLNLKWSRF
SMF1_YEAST DLFTIHELLSRNLA---PAAGTIFMLALLLSGQSAGVVCTMSGQIVSE--GHINWKLQPW
SMF2_YEAST DLFSIYNLLCSTLS---KGAGTVFVLALLFSGQSAGIVCTLSGQMVSE--GFLNWTVSPA
YAV8_SCHPO DLFSIYDLLKEYVS---ISCGRLFAVALLFSGMSAGYVCTIAGQIVSE--GYINWNLRPW
YLR034C_YEAST DLLSIYKLLVHYIS---PAAGLIFALAMLCSGQSAGIICTLAGQIVSE--GFLQWSLPPW
BCG40_MYCLE YIEGTYTAIQDTLG---ATIAMLFAIGLLASSLASASVGAYAGALIMQ--GLLQRSIPML
Y1BI_MYCTU SIEGAYHAVHDTLG---ATIAVLFAVGLLASGLASSSVGAYAGAMIMQ--GLLHWSVPML
YFEP_ECOLI DLDEAYLTLQPLLS---HAAATVFGLSLVAAGLSSTVVGTLAGQVVMQ--GFIRFHIPLW
. . . . . .. . .* * .
O22192_ARATH LRALITRSCAIIPTIIVALVFDSSEATLDVLNEWLNVLQSIQIPFALIPLLCLVSKEQIM
O24209_ORYZA LRAMITRSFAIIPTMIVALFFDTEDPTMDILNEALNVLQSIQIPFALIPLITLVSKEQVM
Q21433_CAEEL KRVLITRAVAITPTLILCIKAHG-IKNLTGMNDFLNCVQMVQLPFALIPMITFTSSKRIM
seqcel KRILITRSLAILPTLAVVIF-----------------------PFALIPVLTFVSDRNIM
Q21434_CAEEL KRVLITRAIAITPTLVLTFYSQG-VQNLTGMNDFLNCVQMIQLPFALIPIITFTSSRKIM
MVL_DROME CRVLVTRCIAIIPTFCLAMFSK--MEDLTSMNDILNAVMSLQLPFAAIPTIAFTSCAAIM
NRAM_CEREL ARVLLTRSCAILPTVLVAVFRD--LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVM
NRM1_BISBI ARVLLTRSCAILPTVLLAVFRD--LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPALM
NRM1_BOVIN ARVLLTRSCAILPTVLLAVFRD--LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPALM
NRM1_BUBAR ARVLLTRSCAILPTVLLAVFRD--LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPALM
NRM1_HUMAN ARVLLTRSCAILPTVLVAVFRD--LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLM
NRM1_MOUSE ARVLLTRSCAILPTVLVAVFRD--LKDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVM
NRM1_CHICK TRVLFTRSLAILPTLFVAAFRD--VSQLTGMNDLLNVLQSILLPFAVLPVLTFTSLRPLM
NRM2_HUMAN ARVVLTRSIAIIPTLLVAVFQD--VEHLTGMNDFLNVLQSLQLPFALIPILTFTYVRPVM
O35172_RAT ARVILTRSIAIIPTLLVAVFQD--VEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM
NRM2_MOUSE ARVILTRSIAIIPTLLVAVFQD--VEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM
SMF1_YEAST QRRLATRCISIIPCLVISICIG--REALSKALNASQVVLSIVLPFLVAPLIFFTCKKSIM
SMF2_YEAST LRRSATRAVAITPCLILVLVAG--RSGLSGALNASQVVLSLLLPFVSAPLLYFTSSKKIM
YAV8_SCHPO LRRVITRAIAIIPCLVVSAAVG--QSGLNQVLNASQVCLSILLPFLTFPLVMFTCSRKVM
YLR034C_YEAST ATRLCTRLIAIVPCLFVTLTMG--EKGISDILNFSQVVLSLILPIVSAPLIYFTANRKLM
BCG40_MYCLE IR----RLITLCPAIAILALG----FDPTRALVLSQIVLSFGIPFAVLPLVKLTNNRGLM
Y1BI_MYCTU VR----RLITLGPALAILTLG----FDPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVM
YFEP_ECOLI VR----RTVTMLPSFIVILMG----LDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLM
* .. *. . * . .*
O22192_ARATH GSFKI-GPLYKTIAWLVAALVIMINGYLLLEFFSNEVS----------GIVYTGFVTLFT
O24209_ORYZA GSFVV-GPITKVISWIVTVFLMLINGYLILSFYATEVR----------GALVRSSLCVVL
Q21433_CAEEL HNFRT-SKPLQYFSIICGIITIGINVYFIFQYVTENFGT---------GWLIFVIIGPFT
seqcel HEY-----VSKVVSIVISLIILFINFYFLYSWIGS-------------------------
Q21434_CAEEL HDFRS-SKVFQIFALITSALILSINVYFISDYVFSRLGS---------EWYIIMVLAPIT
MVL_DROME GEFVN-GL----------------------------------------------------
NRAM_CEREL QEFAN-GLVSKVISSSIMVLVCAVNLYFVISYVPSLP-----------HPDYFSLVALLA
NRM1_BISBI REFAN-GLVSKVITSSIMVLVCAVNLYFVISYVPSLP-----------HPAYFSLVALLA
NRM1_BOVIN QEFAN-GLVSKVITSSIMVLVCAVNLYFVISYLPSLP-----------HPAYFSLVALLA
NRM1_BUBAR QEFAN-GLVSKVITSSIMVLVCAVNLYFVISYVPSLP-----------HPAYFSLVALLA
NRM1_HUMAN QEFAN-GLLNKVVTSSIMVLVCAINLYFVVSYLPSLP-----------HPAYFGLAALLA
NRM1_MOUSE QEFAN-GRMSKAITSCIMALVCAINLYFVISYLPSLP-----------HPAYFGLVALFA
NRM1_CHICK HDFAN-GLLGQVLMSLITGLVCAINVYFVVDFLPTLR-----------GLGYLIPLGLLL
NRM2_HUMAN SDFAN-GLGCRIAGGILVLIICSINMYFVVVYVRDLG-----------HVALYVVAAVVS
O35172_RAT SEFSN-GIGWRIAGGILVLLVCSINMYFVVVYVQELG-----------HVALYVVAAVVS
NRM2_MOUSE SEFSN-GIGWRIAGGILVLIVCSINMYFVVVYVQELG-----------HVALYVVAAVVS
SMF1_YEAST KTEITVDHTEEDSHNHQNNNDRSAGSVIEQDGSSGMEIENGK------DVKIVYMANNWI
SMF2_YEAST RVQLNRTKELSRTTDKKPVADRTEDDETIELEEMGIGSSSQERSLVSPAPEYKDMSNGMI
YAV8_SCHPO RVVSD-----S-TNEETGQLIRETHDYSLGWTMTIVT---------------WAIWLFLT
YLR034C_YEAST VVHDE-NGVVRAPADVNAIADETTPLNSKHSKIVDFTN----------SRLLTYTSVFVW
BCG40_MYCLE GNDTN-HPATTVLGWAVAILVSLLNVVLIYLTVTS-------------------------
Y1BI_MYCTU GGDTN-HRATTWVGWVVAVMVSLLNVMLIYLTVTG-------------------------
YFEP_ECOLI GDLVN-SKRVKQTGWVIVVLVVALNIWLLVGTALGL------------------------
O22192_ARATH ASYGAFILYLIARGITFTPWPFKAESSH-----------------------------
O24209_ORYZA AVYLAFIVYLIMQNTSLYSRLRSAMTKST----------------------------
Q21433_CAEEL LLYIAFILYLAIYCLVACELMNDTVNLPGFDFHRTLELDAPWITETFVVNDVYF---
seqcel ---------------------------------------------------------
Q21434_CAEEL FAYVLFVLYLALYCLVSCEIIPDTVSIRGFSFNKSYENDAPWLAVDSSAVHDNAGYQ
MVL_DROME ---------------------------------------------------------
NRAM_CEREL AAYLGLTTYLVWTCLITQGATLLAHSSHQRFLYGLPEEDQENGRTSG----------
NRM1_BISBI AAYLGLTTYLVWTCLITQGATLLAHSSHQRFLYGLPEEDQEKGRTSG----------
NRM1_BOVIN AAYLGLTTYLVWTCLITQGATLLAHSSHQRFLYGLPEEDQEKGRTSG----------
NRM1_BUBAR AAYLGLTTYLVWTCLITQGATFLAHNSHQRFLYGLPEEDQEKGRTSG----------
NRM1_HUMAN AAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQ-KGETSG----------
NRM1_MOUSE IGYLGLTAYLAWTCCIAHGATFLTHSSHKHFLYGLPNEEQGGVQGSG----------
NRM1_CHICK VAYVAFVTYLLWTCSIAHGARFLARGRYNRFSFDVTADVPGLAGPH-----------
NRM2_HUMAN VAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEEATRGYVK-----------
O35172_RAT VAYLGFVFYLGWQCLIALGLSFLDCGRSVSISKVLLSEDTSGGNTK-----------
NRM2_MOUSE VAYLTFVFYLGWQCLIALGLSFLDCGRSYRLGLTAQPELYLLNTVDADSVVSR----
SMF1_YEAST ITVIAIIVWLFLSLLNVYAIVQLGMSHGDIS--------------------------
SMF2_YEAST VTVLAIIVWLIISGLNFYMLLGFTTGKEVHL--------------------------
YAV8_SCHPO ALNLLLIVWLGMGVSF-----------------------------------------
YLR034C_YEAST ALIGSLNCYLVISYLLGADIHF-----------------------------------
BCG40_MYCLE ---------------------------------------------------------
Y1BI_MYCTU ---------------------------------------------------------
YFEP_ECOLI ---------------------------------------------------------