This phylogenetic tree is based on the alignment indicated below. CLUSTAL W (1.74) multiple sequence alignment ShcLike_cel ------------------------------------------------------------ dShc_droso ------------------------------------------------------------ Shc_human.p52 ------------------------------------------------------------ Shc_human.p66 MNLLPPKPKYNPLRNESLSSMEEGASGSTPPEELPSPPASSLGPILPPLPGDDSPTTLCS Shc_mouse.p66 MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPLPCVP Shc_mouse.p52 ------------------------------------------------------------ N-Shc_human.p52 ------------------------------------------------------------ N-Shc_human.p64 ---MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP N-Shc_rat.p66 ---MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGGKVSAE---PAASPYLVSGEALRKAP N-Shc_rat.p52 ------------------------------------------------------------ N-Shc_mouse.p52 ------------------------------------------------------------ Sck_rat.part ------------------------------------------------------------ Sck_human.part ---------------------------------------------------IRGSNAQKV ShcLike_cel ------------------------------------------------------------ dShc_droso ------------------------------------------------------------ Shc_human.p52 --------------------------------------------------MNKLSGGGGR Shc_human.p66 FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR Shc_mouse.p66 SFPRMSNLKLANPAGGPWGLKGSQERLLKMGKGVQGQPFG-LRPLAPPPDMNKLSGGGGR Shc_mouse.p52 --------------------------------------------------MNKLSGGGGR N-Shc_human.p52 ------------------------------------------------------------ N-Shc_human.p64 DDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLS--GSCSAPSLAAPDGSAP-- N-Shc_rat.p66 DDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLS--GSCSAPSLAAPDGGSATP N-Shc_rat.p52 ------------------------------------------------------------ N-Shc_mouse.p52 ------------------------------------------------------------ Sck_rat.part ------------------------------------------------------------ Sck_human.part VGASGSGGAGPQPDPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGR ShcLike_cel ------------------------MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVM dShc_droso ------MPKNGDAGNRSG---SGTTSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSL Shc_chick.part -----------------G-SFVNKPTRGWLHPDDKVMGPGVSYHVRYMGCVEVLQSMRAL Shc_human.p52 RTRVEGGQLGGEEWTRHG-SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRAL Shc_human.p66 RTRVEGGQLGGEEWTRHG-SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRAL Shc_mouse.p66 RTRVEGGQLGGEEWTRHG-SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRAL Shc_mouse.p52 RTRVEGGQLGGEEWTRHG-SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRAL Shc_rat.part -----------------------------LHPNDKVMGPGVSYLVRYMGCVEVLQSMRAL N-Shc_human.p52 --------MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSL N-Shc_human.p64 SAPR-APAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSL N-Shc_rat.p66 GSRAPAASMSATRKSRASDEPLPRPPRGAPHASDQVLGSGVTYVVKYLGCIEVLRSMRSL N-Shc_rat.p52 --------MSATRKSRASDEPLPRPPRGAPHASDQVLGSGVTYVVKYLGCIEVLRSMRSL N-Shc_mouse.p52 --------MSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYLGCIEVLRSMRSL N-Shc_fugu.p52 ---------------------MSKPSRGWVHSSDKISGPGVTYIVKYLGCIEVLRSMRSL Sck_rat.part -------PDVADEWVRKG-GFIHKPAHGWLHPDARVLGPGVSYIVRYMGCIEVLRSMRSL Sck_human.part GAAGSGDAAAAAEWIRKG-SFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSL : . **: . * *.: * *:. : ShcLike_cel VSEMRVQVVSECIQHV--AATVGVTAAREINP-------VVSRVIGEVKKENFPVDINIS dShc_droso DFETRTQLARECINRVCEAA-GLKSAGKRRLT-----NFISDRPSMQHAGTNIIINVSSR Shc_chick.part DFNTRTQVTREAIGLVCEAVPGAKGAVRRRKPCGRSLNSILGKSNLKFAGVPITLTISTS Shc_human.p52 DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTS Shc_human.p66 DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTS Shc_mouse.p66 DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTS Shc_mouse.p52 DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTS Shc_rat.part DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTS N-Shc_human.p52 DFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTA N-Shc_human.p64 DFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTA N-Shc_rat.p66 DFSTRTQVTREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTA N-Shc_rat.p52 DFSTRTQVTREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTA N-Shc_mouse.p52 DFSTRTQVTREAISRVCERVPGAKGALKKRKPPSKMLSSILGKSNLQFAGMSISLTISTA N-Shc_fugu.p52 DFTTRSQITREAISLVCEAVPGTKGALRKRKPPSKTLSSILGKSNLQFAGMSINLNISTS Sck_rat.part DFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASILGKSNLRFAGMSISVNISVD Sck_human.part DFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASVLGKSNLRFAGMSISIHISTD * *:. *.* : . : :. . : .: . : : :. ShcLike_cel SKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVV------ dShc_droso ALSLSNVETGEVIANHNMPRISFASGGD--NDTLDFLAYIAKNED-EWAACYVLECAGGQ Shc_chick.part SLNLMASDCKQIHCQPSHASISFASGGD--PDTAEYVAYVAKDPV-NQRACHILECPEGL Shc_human.p52 SLNLMAADCKQIIANHHMQSISFASGGD--PDTAEYVAYVAKDPV-NQRACHILECPEGL Shc_human.p66 SLNLMAADCKQIIANHHMQSISFASGGD--PDTAEYVAYVAKDPV-NQRACHILECPEGL Shc_mouse.p66 SLNLMAADCKQIIANHHMQSISFASGGD--PDTAEYVAYVAKDPV-NQRACHILECPEGL Shc_mouse.p52 SLNLMAADCKQIIANHHMQSISFASGGD--PDTAEYVAYVAKDPV-NQRACHILECPEGL Shc_rat.part SLNLMAADCKQIIANHHMQSISFASGGD--PDTAEYVAYVAKDPV-NQRA---------- N-Shc_human.p52 SLNLRTPDSKQIIANHHMRSISFASGGD--PDTTDYVAYVAKDPV-NRRACHILECCDGL N-Shc_human.p64 SLNLRTPDSKQIIANHHMRSISFASGGD--PDTTDYVAYVAKDPV-NRRACHILECCDGL N-Shc_rat.p66 SLNLRTPDSKQIISNHHMRSISFASGGD--PDTTDYVAYVAKDPV-NRRACHILECCDGL N-Shc_rat.p52 SLNLRTPDSKQIISNHHMRSISFASGGD--PDTTDYVAYVAKDPV-NRRACHILECCDGL N-Shc_mouse.p52 SLNLRTPDSKQIIANHHMRSISFASGGD--PDTTDYVAYVAKDPV-NRRACHILECCDGL N-Shc_fugu.p52 SLNLMTPDGKQIIANHHMQSISFASGGD--PDTTDYVAYVAKDPV-NRRACHILECSDGL Sck_rat.part GLNLSVPATRQIIANHHMQSISFASGGD--TDMTDYVAYVAKDPI-NQRACHILECCEGL Sck_human.part GLSLSVPATRQVIANHHMPSISFASGGD--TDMTDYVAYVAKDPI-NQRACHILECCEGL . : .: . :**.: *: * ..*:**: ShcLike_cel ------------------------------------------------------------ dShc_droso SEDLIVTIGKAFALRFNALSRLN------DPSADCNINQS--CKENVK---E-YYNDLPN Shc_chick.part AQDVISTIGQAFELRFKQYLKNP-PKLVTPHDRMAGFEWL-------------------- Shc_human.p52 AQDVISTIGQAFELRFKQYLRNP-PKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPG Shc_human.p66 AQDVISTIGQAFELRFKQYLRNP-PKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPG Shc_mouse.p66 AQDVISTIGQAFELRFKQYLRNP-PKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPG Shc_mouse.p52 AQDVISTIGQAFELRFKQYLRNP-PKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPG N-Shc_human.p52 AQDVIGSIGQAFELRFKQYLQCP-TKIPALHDRMQSLDEP-WTEEEGDGSDHPYYNSIPS N-Shc_human.p64 AQDVIGSIGQAFELRFKQYLQCP-TKIPALHDRMQSLDEP-WTEEEGDGSDHPYYNSIPS N-Shc_rat.p66 AQDVIGSIGQAFELRFKQYLQCP-SKIPALQDRMQSLDEP-WTEEEGDGPDHPYYNSVPN N-Shc_rat.p52 AQDVIGSIGQAFELRFKQYLQCP-SKIPALQDRMQSLDEP-WTEEEGDGPDHPYYNSVPN N-Shc_mouse.p52 AQDVIGSIGQAFELRFKQYLQCP-SKVPALQDRMQSLDEP-WTEEEGDGPDHPYYNSVPT N-Shc_fugu.p52 AQDVIGTIGQAFDLRFQQYLQCPSSKISSPHDRVLNMEELTWTEEEEESTEHPYYNNIPG Sck_rat.part AQSVISTVGQAFELRFKQYLHSP-PKAVVPPERLTGLEESAWGDGEVT-ADHDYYNSIPG Sck_human.part AQSIISTVGQAFELRFKQYLHSP-PKVALPPERLAGPEESAWGDEEDS-LEHNYYNSIPG ShcLike_cel ------------------------------------------------------------ dShc_droso KLPPEVPEPQQQQVQQPLHPHAPRVAQ------L-NLKKPR----------DRLSSNLI- Shc_human.p52 KEPPLGGVVDMRLREGAAPGAARPTAP---NAQTPSHLGAT-LP-----VGQPVGGDPE- Shc_human.p66 KEPPLGGVVDMRLREGAAPGAARPTAP---NAQTPSHLGAT-LP-----VGQPVGGDPE- Shc_mouse.p66 KEPPLGGVVDMRLREG----AARPTLP---SAQMSSHLGAT-LP-----IGQHAAGDHE- Shc_mouse.p52 KEPPLGGVVDMRLREG----AARPTLP---SAQMSSHLGAT-LP-----IGQHAAGDHE- N-Shc_human.p52 KMPPPGGFLDTRLKPRP---HAPDTAQFA-G-KEQTYYQGR-------HLGDTFGEDWQQ N-Shc_human.p64 KMPPPGGFLDTRLKPRP---HAPDTAQFA-G-KEQTYYQGR-------HLGDTFGEDWQQ N-Shc_rat.p66 KMPPPGGFLDARLKARP---HAPDAAQFS-G-KEQTYYQGR-------HLGDAFGEDWQR N-Shc_rat.p52 KMPPPGGFLDARLKARP---HAPDAAQFS-G-KEQTYYQGR-------HLGDAFGEDWQR N-Shc_mouse.p52 KMPPPGGFLDARLKGRP---HAPEAAQFA-G-KEQTYYQGR-------HLGDTFGEDWQR N-Shc_fugu.p52 KMPPPGGIVDTRLTNQN---AAQDGCQMGPGSIDQTYYQGR-------HCGENWGDDRKP Sck_rat.part KEPPLGGLVDSRLAVTQP--CALTTLGGLGQGLSPAWRDVRGLPWDMGPSGAVPPGDGY- Sck_human.part KEPPLGGLVDSRLALTQP--CALTALD---QGPSPSLRDACSLPWDVGSTGTAPPGDGY- ShcLike_cel --------FIEDVHK------LIDVLTTAINVNTFDAQAN-------------------- dShc_droso --------DLNSPPP----------DQTTNKLGHFDPLQ--------------------- Shc_human.p52 --VRK---QMPPPPPCPGR--ELFDDPSYVNVQNLDKARQA------------------- Shc_human.p66 --VRK---QMPPPPPCPGR--ELFDDPSYVNVQNLDKARQA------------------- Shc_mouse.p66 --VRK---QMLPPPPCPGR--ELFDDPSYVNIQNLDKARQA------------------- Shc_mouse.p52 --VRK---QMLPPPPCPGR--ELFDDPSYVNIQNLDKARQA------------------- N-Shc_human.p52 TPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWP------------------- N-Shc_human.p64 TPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWP------------------- N-Shc_rat.p66 APTRQGSLDIYSTPEGKAHMVPVGETPTYVNTQPVPPQVWP------------------- N-Shc_rat.p52 APTRQGSLDIYSTPEGKAHMVPVGETPTYVNTQPVPPQVWP------------------- N-Shc_mouse.p52 APTRQGSLDIYSTAEGKTHMVPVGETPTYVNTQPVPPQVWP------------------- N-Shc_fugu.p52 IFIQQGSFDIISLPESKGQ-AQRAEMPAYVNTQQIDAQVLAALQAEGENVTKGLASAPAK Sck_rat.part --VQA---DARGPHD--------YEEHLYVNTQGLDALELE------------------- Sck_human.part --VQA---DARGPPD--------HEEHLYVNTQGLDAPE--------------------- ShcLike_cel ------------------------------------------------------------ dShc_droso ------------------------------------------------------------ Shc_human.p52 ------------------------------------------------------------ Shc_human.p66 ------------------------------------------------------------ Shc_mouse.p66 ------------------------------------------------------------ Shc_mouse.p52 ------------------------------------------------------------ N-Shc_human.p52 ------------------------------------------------------------ N-Shc_human.p64 ------------------------------------------------------------ N-Shc_rat.p66 ------------------------------------------------------------ N-Shc_rat.p52 ------------------------------------------------------------ N-Shc_mouse.p52 ------------------------------------------------------------ N-Shc_fugu.p52 ESPQKDLFDMSSPLRMPFNPRDQNIPRQQVFTRQRLWTMPARFWCVPWPSGRRRSWRARR Sck_rat.part ------------------------------------------------------------ Sck_human.part ------------------------------------------------------------ ShcLike_cel ------------ASTSNDGFTVPAPPMRHRSSLHRQS-------------------FVSN dShc_droso ---------------ATTAANSVLPSVRD---VFDG----------------------P- Shc_human.p52 -----VGGAGPPNPAINGSAPRDLFDMKPFEDALRV--------------------P-PP Shc_human.p66 -----VGGAGPPNPAINGSAPRDLFDMKPFEDALRV--------------------P-PP Shc_mouse.p66 -----GGGAGPPNPSLNGSAPRDLFDMKPFEDALRV--------------------P-PP Shc_mouse.p52 -----GGGAGPPNPSLNGSAPRDLFDMKPFEDALRV--------------------P-PP N-Shc_human.p52 ----------AAVSSAESSPRKDLFDMKPFEDALKNQ---PLGPVLSKAASVEC--ISPV N-Shc_human.p64 ----------AAVSSAESSPRKDLFDMKPFEDALKNQ---PLGPVLSKAASVEC--ISPV N-Shc_rat.p66 ----------AATSSTESSPRKDLFDMKPFEDALRNQ---PLGPVLSKAASVEC--ISPV N-Shc_rat.p52 ----------AATSSTESSPRKDLFDMKPFEDALRNQ---PLGPVLSKAASVEC--ISPV N-Shc_mouse.p52 ----------AATSSTESSPRKDLFDMKPFEDALRNQ---PLGPMLSKAASVEC--ISPV N-Shc_fugu.p52 GTMAS Sck_rat.part -----DTSETPLQP--EDSPKKDLFDMRPFEDALKLHECSVAAGITAASLPLEDQWPSPP Sck_human.part -------------P--EDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPP . :: . ShcLike_cel CRAPTVT---EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENE dShc_droso --QCPLT-------AEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTG-LEGKT Shc_human.p52 PQSVSMA---EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTG-LQSGQ Shc_human.p66 PQSVSMA---EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTG-LQSGQ Shc_mouse.p66 PQSMSMA---EQLQGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTG-LQSGQ Shc_mouse.p52 PQSMSMA---EQLQGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTG-LQSGQ N-Shc_human.p52 SPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTG-MHNGQ N-Shc_human.p64 SPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTG-MHNGQ N-Shc_rat.p66 TPRAPDAKMLEELNAEPWYQGEMSRKEAEALLQEDGDFLVRKSTTNPGSFVLTG-MHNGQ N-Shc_rat.p52 TPRAPDAKMLEELNAEPWYQGEMSRKEAEALLQEDGDFLVRKSTTNPGSFVLTG-MHNGQ N-Shc_mouse.p52 TPRAPDARMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTG-MHNGQ Sck_rat.part TRRAPIAPTEEQLRQEPWYHGRMSRRAAEKLLRADGDFLVRDSITNPGQYVLTG-MHAGQ Sck_human.part TRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTG-MHAGQ . : : *::. :** :: :*. :******.* . *.:**:* ShcLike_cel HKHLILLDNHNVRPSPPPPAKPSNLSKFQRVRTRDRTFSNISELIDYHVNNGMAVRSEGR dShc_droso PKHLLLID------------------PEGVVRTKDRIFDSISHLINYHWAHALPIISEDS Shc_human.p52 PKHLLLVD------------------PEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS Shc_human.p66 PKHLLLVD------------------PEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS Shc_mouse.p66 PKHLLLVD------------------PEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS Shc_mouse.p52 PKHLLLVD------------------PEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS N-Shc_human.p52 AKHLLLVD------------------PEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS N-Shc_human.p64 AKHLLLVD------------------PEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS N-Shc_rat.p66 AKHLLLVD------------------PEGTVRTKDRVFDSISHLITYHLESSLPIVSAGS N-Shc_rat.p52 AKHLLLVD------------------PEGTVRTKDRVFDSISHLITYHLESSLPIVSAGS N-Shc_mouse.p52 AKHLLLVD------------------PEGTIRTKDRVFDSISHLINYHLESSLPIVSAGS Sck_rat.part PKHLLLVD------------------PEGVVRTKDVLFESISHLIDYHLKNGLPIVAAES Sck_human.part PKHLLLVD------------------PEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES ***:*:* :**:* *..:*.** :* .: : ShcLike_cel DRETSLNLIRPVPCPGSDDIE---- dShc_droso ELVLRNPVRRPQQDQAASPITSASS Shc_human.p52 ELCLQQPVERKL------------- Shc_human.p66 ELCLQQPVERKL------------- Shc_mouse.p66 ELCLQQPVDRKV------------- Shc_mouse.p52 ELCLQQPVDRKV------------- N-Shc_human.p52 ELCLQQPVERKQ------------- N-Shc_human.p64 ELCLQQPVERKQ------------- N-Shc_rat.p66 ELCLRQPVERKP------------- N-Shc_rat.p52 ELCLRQPVERKP------------- N-Shc_mouse.p52 ELCLQQPVERKP------------- Sck_rat.part ELHLRGVVSREP------------- Sck_human.part ELHLRGVVSREP------------- : : *
Laurent Duret
Laboratoire de Biométrie, Génétique et Biologie des Populations.
UMR CNRS 5558
Université Claude Bernard - Lyon 1
43, bd. du 11 Novembre 1918
69622 Villeurbanne Cedex
France
Tel: +33 (0) 4 72 44 62 97
Fax: +33 (0) 4 78 89 27 19
E-mail:duret@biomserv.univ-lyon1.fr
January 5, 2000
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