CLUSTAL W (1.7) multiple sequence alignment S.enterica -------------------------------------------------------MTDNR S.typhimurium -------------------------------------------------------MTDNR E.coli -------------------------------------------------------MTNYR Y.pestis -------------------------------------------------------MLNGR D.radiodurans -------------------------------------MDSRSPSLPDDRPDPPEQHLDAR B.subtilis ------------------------------------------------MMNKDITAQSPR C.acetobutylicum_1 --------------------------------------------MDKLSIREDNYNIKHK M.bovis -------------------------------------------------LSHLCS-RGSK M.tuberculosis ------------------------------------------MAGEFRLLSHLCS-RGSK M.leprae ---------------------------------------------MFVNLTCLSEGNGSR L.monocytogenes ------------------------MKKDKTERTKQSW---------RKAQ----NAPSLS L.innocua ------------------------MKKEKTERTKQSW---------RKAQ----NAPSLS Anabaena ------------------------------------M---------TPPE----NRPSLP A.tumefasciens ---------MFFMRMICNCINSISMKAQKMDKPVFGW---------RRNG----DDLSLS P.aeruginosa_1 ------------------------MSAKDTPAPQA-------------------AEP--G X.fastidiosa MSCGIANAIRWDVSLLIHRSMSSSMSSVQPTSPVS-------------------DSPSLG R.loti ------------------------MSDAEATAPRSSW---------RFAGRDEDDQPSLR P.aeruginosa_2 ---------------------------MKYSLPTTAT-----------------APFCPS P.aeruginosa_3 ------------------------------------------------------------ B.solanacearum -------------------------MFRLPALPRIPT-----------------APFCPS B.cepacia ------------------------------------------------------------ S.aureus_1 ----------------------------------MNN---------KRHSTNE--QLSLD S.aureus_2 ----------------------------------MNN---------KRHSTNE--QLSLD L.brevis ------------------MKEGIDMRESVAEEPKHKF---------FQSTEGE--NKSLD L.lactis ------------------------MND--KEHQRHRL---------IYHTNG----KSLE S.cerevisiae_1 ------------------------------------------------------------ S.cerevisiae_2 --------------MTSQEYEPIQWSDESQTNNDSVN-------DAYADVNTTHESRRRT S.cerevisiae_3 --MVNVGPSHAAVAVDASEARKRNISEEVFELRDKKDSTVVIEGEAPVRTFTSSSSNHER C.acetobutylicum_2 ----------------------------------------------------------MR S.enterica VENSSG-----RAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWAN S.typhimurium VENSSG-----RAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWAN E.coli VESSSG-----RAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWAN Y.pestis AVDTSR-----RPLRKIKLSLMGPAFIAAIAYIDPGNFATNIQAGATFGYTLLWVVVWAN D.radiodurans AGATLRGTAGPRGVRRI-LPFLGPAVIASIAYMDPGNFATNIEGGARYGYSLLWVILAAN B.subtilis SKAVQDALDGKIRGFRGLLPFLGPAFIAAIAYIDPGNFATNISAGSKYGYMLLWVILFSN C.acetobutylicum_1 TISLNRASS-VTRNLKGLLKFLGPAFVVSVAYIDPGNFATNISGGSSFNYNLIWVILWSN M.bovis VGELAQDT---RTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAAN M.tuberculosis VGELAQDT---RTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAAN M.leprae GKALAEST---QAELKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLQLWVVVVAN L.monocytogenes EVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGNWATSIAGGSEFGYTLLSVILISN L.innocua EVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGNWATSIAGGSEFGYTLLSVILISN Anabaena EVHRSIRVPNSNSFWRKMLAYAGPGYLVSVGYIDPGNWATDIAGGSKFGYTLLTVILLSN A.tumefasciens DVHSSIRIKPDASTFRRAMAFFGPGYLVAVGYMDPGNWATSLAGGSKFGYTLLAVALVSN P.aeruginosa_1 RAQP-VEVPGGGHWWRRLLAFAGPGYLVAVGYMDPGNWATDVAGGAQLGYLLLSVILLSS X.fastidiosa EMHASVAVSRRGHWGFRLLAFLGPGYMVSVGYMDPGNWATGLAGGSRFGYMLLSVILLSN R.loti EVNSTIAVPSSGVWFRRLFAFMGPGYMVSVGYMDPGNWATDLAGGAQFGYTLLFVIMLSN P.aeruginosa_2 AVSHSVAVPADASPLRKLALFVGPGLLVSVGYMDPGNWATAIEAGSRFGYALLFVVVLAS P.aeruginosa_3 -----MAVPADASPLRKLALFVGPGLLVSVGYMDPGNWATAIEAGSRFGYALLFVVVLAS B.solanacearum EVRGCVAIPPDLPLWKKLLRFAGPGLLVSVGYMDPGNWATDIEAGSRYGYSLLFVVLLSS B.cepacia -------------------------------------WATDIQAGSQFGYSLLWVVAFSS S.aureus_1 EINNTIKFDHRSSNKQKFLSFLGPGLLVAVGYMDPGNWITSMQGGAQYGYTLLFVILISS S.aureus_2 EINNTIKFDHRSSNKQKFLSFLGPGLLVAVGYMDPGNWITSMQGGAQYGYTLLFVILISS L.brevis EVNGSVKVPKNAGFWRTLFAYTGPGILIAVGYMDPGNWITSIAGGAQFKYSLLSVILISS L.lactis EINGTVEVPKNVGFFKMLLTYSGPGALVAVGYMDPGNWSTSITGGQNFQYLLISVILMSS S.cerevisiae_1 -------MRSYMQILQKFAKFIGPGILVSVAYMDPGNYATSVSGGAQYKYTLLFSIFISN S.cerevisiae_2 TLQPNSTSQSMIGTLRKYARFIGPGLMVSVSYMDPGNYSTAVAAGSAHRYKLLFSVLVSN S.cerevisiae_3 EDTYVSKRQVMRDIFAKYLKFIGPGLMVSVAYIDPGNYSTAVDAGASNQFSLLCIILLSN C.acetobutylicum_2 KINIFKGKHNPQRTAIDFFKYVGPGLLVTVGFIDPGNWASNVSAGSDYGYSLLWIVTLST S.enterica LMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGF S.typhimurium LMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGF E.coli LMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGF Y.pestis VMAMLVQLLSAKLGIATGKNLAEHIRDRFPRPVVWAYWVQAEIIVMATDLAEFIGAAIGF D.radiodurans LMAMVIQNLSANLGIASGRNLPELIRERWPRPLVWFYWIQAELVAMATDLAEFLGAALAI B.subtilis IMALLIQSLSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVIIATDLAEFIGAALGL C.acetobutylicum_1 LMAIFLQTMSAKLGIATGCSLPEMCAKVFSKRANWIFWIVGELGAMATDLAEFIGGTLGL M.bovis VMAALVQYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIAL M.tuberculosis VMAALVQYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIAL M.leprae VLAGLVQYLSAKLGLVTGQSLPQAISKQMSHPFRLGFWLQAELVAMATDVAEIVGGAIAF L.monocytogenes ILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVLWILAELAIIATDIAEVIGSAIAL L.innocua ILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVLWILAELAIIATDIAEVIGSAIAL Anabaena LMAILLQSLCVRLGVATGRDLAQACRDYFSPKVSFCLWVLCEIAIAACDLAELLGSAIAL A.tumefasciens IMAIVLQSLCARLAIASGRDLAQACRDAYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGL P.aeruginosa_1 LMAMLLQALSARLGIASGLDLAQACRERYSPSTCRLLWLACETAIIACDLAEVIGTAIAL X.fastidiosa VMAIVLQALAARLGIASDMDLAQACRARYSRGTTLALWVVCELAIIACDLAEVIGTAIAL R.loti LMAILLQALAARLGIATGRDLAQACRAYYPRPVNFVLWIACELAIIACDLAEVIGTAIAL P.aeruginosa_2 FSGMLLQSLCSRLGIATGRDLAQLSRERYRPGVARGQWLLAELSIVATDLAEVLGAALAF P.aeruginosa_3 FSGMLLQSLCSRLGIATGRDLAQLSRERYRPGVARGQWLLAELSIVATDLAEVLGAALAF B.solanacearum LAAMVLQCLSARLGIVTGKDLARLSRERYRPGAVRVQWLLAELSIVACDLAEVLGCALAF B.cepacia LAAIFLQMLAARLGLVAGKDLAQASYERYGRFGRVVQWITAEVSIIACDIAEVLGCALAF S.aureus_1 LSAMLLQSMTVRLGIATGMDLAQMTRHYLSRPIAIIFWIIAELAIIATDIAEVIGSAIAL S.aureus_2 LSAMLLQSMTVRLGIATGMDLAQMTRHYLSRPIAIIFWIIAELAIIATDIAEVIGSAIAL L.brevis LIAMLLQSMAARLGIVTGKDLAQLTRERTSKTMGIILWLITESAIMATDVAEIIGSGIAI L.lactis LIAMLLQYMSAKLGIVSQMDLAQAIRARTSKSLGIVLWILTELAIMATDIAEVIGAAIAL S.cerevisiae_1 IFAVLLQCLCVKLGTITGYDLAENCRHNLPKKLNYTLYLFAEVAIIATDLAEVVGTAIAL S.cerevisiae_2 FMAAFWQYLCARLGAVTGLDLAQNCKKHLPFGLNITLYILAEMAIIATDLAEVVGTAISL S.cerevisiae_3 FIAIFLQCLCIKLGSVTGLDLSRACREYLPRWLNWTLYFFAECAVIATDIAEVIGTAIAL C.acetobutylicum_2 IMLIILQHNAAHLGIVTGDCLSEAVSKKFKPWLTNIILYSAIGAAISTAMAELLGGAIAL S.enterica KLILGVSLLQGAVLTGIATFLILMLQ-RRGQ------KPLEKVIGGLLLFVAAAYIVELF S.typhimurium KLILGVSLLQGAVLTGIATFLILMLQ-RRGQ------KPLEKVIGGLLLFVAAAYIVELF E.coli KLILGVSLLQGAVLTGIATFLILMLQ-RRGQ------KPLEKVIGGLLLFVAAAYIVELI Y.pestis KLLFGVTLLQGAVLTGIATFLILMLQ-NRGQ------KPLELVIGGLLLFVAAAYIVELI D.radiodurans QLLTGLPMFWGAVVTGVVTFWLLNLQ-KRGT------RPLELAVGAFVLMIGVAYLVQVV B.subtilis YLLFGIPMLEASIIAAIGSFAILELQ-RRGY------RSLEAGIAGMLFVVVIAFALQTF C.acetobutylicum_1 YLLFRIPMIYAGLLTGVLTFIIVYME-KYGQ------KMVETIIAALIAVICVAYTIELF M.bovis RIMFNLPLPIGGIITGVVSLLLLTIQDRRGQ------RLFERVITALLLVIAIGFTASFF M.tuberculosis RIMFNLPLPIGGIITGVVSLLLLTIQDRRGQ------RLFERVITALLLVIAIGFTASFF M.leprae HILFRVSLLLGGVITGTVSLLLLMVKDRRGQ------LLFERVITGLLFVIVVGFTSSFF L.monocytogenes NLLFGIPLIWGVCITALDIFLVLFLQ-HKGF------RYIEVIVITLMVTILVCFGAEMV L.innocua NLLFGIPLIWGVCITALDIFLVLFLQ-HKGF------RYIEVIVITLMVTILVCFGAEMV Anabaena QLLFVIPLIWGVCITALDVLVLLFLQ-HKGF------RYTEALVIMLVATVGICFTAEIL A.tumefasciens NLIFGIPLELGVLITALDVFLILYLQ-KLGF------RWVEALVITLLGVIAVCFAIQLA P.aeruginosa_1 KLLFGLPLAWGALLCVGDALLVLVLI-GRGQ------RPLEAFVVALLTLIFACFAVQLL X.fastidiosa NLLLGVPIIWGVVITAVDVVLVLLLM-HRGF------RALEAFVIALLLVIFGCFVVQIV R.loti KLLFGIPLIGGAILTALDAFLVLLLM-NKGF------RYLEAFVIALLIIIFSCFAIQIF P.aeruginosa_2 HLLLGVSITTGVVLTAFDTLIVLALQ-GANF------RRLEAIVLGLIATIGACFFVELV P.aeruginosa_3 HLLLGVSITTGVVLTAFDTLIVLALQ-GANF------RRLEAIVLGLIATIGACFFVELV B.solanacearum HLLLGVPILGGVALTALDTLIVLGLK-GKNF------RQLEAIVLGLILTIGLCYFVELA B.cepacia KLLLGVPLAWGVVLTALDTVIVLGLQ-GKGF------RQIEAIVLGLIATMAFCFVAQVA S.aureus_1 NLLFNIPLIVGALITVLDVFLLLFIM-KYGF------RKIEAIVGTFIFTVLFIFIFEVY S.aureus_2 NLLFNIPLIVGALITVLDVFLLLFIM-KYGF------RKIEAIVGTLIFTVLFIFIFEVY L.brevis KLLFNIPLVVGILITTADVLILLLLM-KLGF------RKIEAIVATLVAVILLVFTYEVF L.lactis YLLFNIPLILAVFITVLDVFLLLLLT-RVGF------RKIEALVICLILVILVIFAYQVA S.cerevisiae_1 QILFKIPLTWGVLLTVLDVLVILMFY-TPNGQSLKKVRVFEFGVGILVIGTCICFVLELF S.cerevisiae_2 NILFHIPLALGVILTVVDVLIVLLAY-KPNG-SMKGIRIFEAFVSLLVVLTVVCFTVELF S.cerevisiae_3 NILIKVPLPAGVAITVVDVFLIMFTY-KPGASSIRFIRIFECFVAVLVVGVCICFAIELA C.acetobutylicum_2 NMLFRLPIKIGTLIMLSLVIWMLFSS---SY------KKLERWIIGFVSIIGLSFIFELL S.enterica FSQPD--MAQLGKGMVIP------ALPNP---EAVFLAAGVLGATIMPHVIYLHSSLTQ- S.typhimurium FSQPD--MAQLGKGMVIP------ALPNP---EAVFLAAGVLGATIMPHVIYLHSSLTQ- E.coli FSQPN--LAQLGKGMVIP------SLPTS---EAVFLAAGVLGATIMPHVIYLHSSLTQ- Y.pestis FSQPD--IAALGRGMLIP------NLPDG---NAVFLAAGVLGATIMPHVIYLHSALTQ- D.radiodurans LARPD--LAAVGAG-FVP------RLQGP---GSAYLAVGIIGATVMPHVIYLHSALTQG B.subtilis FAKPD--AVSVMKGLFVP------AFHGT---DSVLLAAGILGATVMPHAIYLHSALTQR C.acetobutylicum_1 LARPA--WTQVGMHTLIP------SLPNG---EAVLIAVGMLGATVMPHVIYLHSELVQH M.bovis VVTPP--PNAVLGG-LAP------RFQGT---ESVLLAAAIMGATVMPHAVYLHSGLARD M.tuberculosis VVTPP--PNAVLGG-LAP------RFQGT---ESVLLAAAIMGATVMPHAVYLHSGLARD M.leprae VATPS--PEDMVNG-LLP------RFQGT---ESVLLAAAIIGATVMPHAVYLHSGLALD L.monocytogenes MSHPD--MQAIAKG-FIP------QSEIVTNPAMLYIALGILGATVMPHNLYLHSSIVQT L.innocua MSHPD--MQAIAKG-FIP------QSEIVTNPAMLYIALGILGATVMPHNLYLHSSIVQT Anabaena FSRPD--MGGILLG-YLP------KKEILQNPEMLYIAIGILGATVMPHNLYLHSSIVQT A.tumefasciens LADPD--WGQVILG-FAP------TTEIVTNPDMLYLALGILGATVMPHNLYLHSGIVQT P.aeruginosa_1 LSRPE--LGEVLQG-FLP------SPRVLSDPAALYLAIGIVGATVMPHNLYLHSSLVQS X.fastidiosa LAAPP--LQEVLGG-FVP------RWQVVADPQALYLAIGIVGATVMPHNLYLHSSIVQT R.loti VAAPP--AGTILHSMFVP------SSEIVTNPAMLYIAIGIIGATVMPHNLYLHSSIVQT P.aeruginosa_2 LIGPY--WPDVAAG-LRP------SWDTLSSQEPLYLAIGILGATVMPHNLYLHSSVVQT P.aeruginosa_3 LIGPY--WPDVAAG-LRP------SWDTLSSQEPLYLAIGILGATVMPHNLYLHSSVVQT B.solanacearum LIRPH--WPSVAGA-LVP------SWQALSAREPLYLAIGILGATVMPHNLYLHSSIVQT B.cepacia ITPPD--WHAVVGG-LVP------GDPGHDRKDAIVLALGIVGATI-------------- S.aureus_1 ISSPQ--LNAVLNG-FIP------HSEIITNNGILYIALGIIGATIMPHNLYLHSSIVQS S.aureus_2 ISSPQ--LNAVLNG-FIP------HSEIITNNGILYIALGIIGATIMPHNLYLHSSIVQS L.brevis LAGPQ--LDQMFAG-YMP------TKDIVTNKSMLYLALGIVGATVMPHDLYLGSSISQT L.lactis LSNPD--WKGIIEG-FIPNSRTFASSPTVAGMSPLTGALGIIGATVMPHNLYLHSSISQS S.cerevisiae_1 KVSIP-DKAELFKG-FLP------SNIIFKEQQALYISLGILGATVMPHSLYLGSSIVKP S.cerevisiae_2 YAKLG-PAKEIFSG-FLP------SKAVF-EGDGLYLSLAILGATVMPHSLYLGSGVVQP S.cerevisiae_3 YIPKSTSVKQVFRG-FVP------SAQMF-DHNGIYTAISILGATVMPHSLFLGSALVQP C.acetobutylicum_2 LVKVN--WQVAAVSFVSP------SFPKN----SMPIIMSVLGAVVMPHNLFLHSEIIQS S.enterica -----------------------------------HLHGGTRQQR---YSATKWDVAIAM S.typhimurium -----------------------------------HLHGGTRQQR---YSATKWDVAIAM E.coli -----------------------------------HLHGGSRQQR---YSATKWDVAIAM Y.pestis -----------------------------------TGGEESKTER---YASTKFDVAIAM D.radiodurans -----------------------------------RIQTDTTEEKRRLVRLNRVDVIAAM B.subtilis -----------------------------------RVVGKTDAERKKIFRFEFIDILIAM C.acetobutylicum_1 -----------------------------------RNTNSSDKEKLHHLKMEKIDILIAM M.bovis R----------------------------------HGHPDPGPQRRRLLRVTRWDVGLAM M.tuberculosis R----------------------------------HGHPDPGPQRRRLLRVTRWDVGLAM M.leprae R----------------------------------HGHPHAGRSRRRLLRVTRLDVILAM L.monocytogenes R-----------------------------Q-----YAR-TKEGKKEAIRFSFIDSTFSL L.innocua R-----------------------------Q-----YAR-TKEGKREAIRFSFIDSTFSL Anabaena R-----------------------------D-----WQP-TTEKRWEAIKFGTIDSTFAL A.tumefasciens R-----------------------------E-----IGP-TIAEKREALKFATLDSTIAL P.aeruginosa_1 R-----------------------------A-----YPR-SLAGKRKALRWAVADSSLAL X.fastidiosa R-----------------------------A-----YPR-TPVGRRSALRWAVADSTLAL R.loti R-----------------------------A-----YER-TEKGKRDAIKWATTDSTIAL P.aeruginosa_2 R-----------------------------V-----SGD-DAASKRSAIRFSRLDTIGSL P.aeruginosa_3 R-----------------------------V-----SGD-DAASKRSAIRFSRLDTIGSL B.solanacearum R-----------------------------V-----VSE-TEPARREAVGLSRLDTIVSL B.cepacia ------------------------------------------------------------ S.aureus_1 R-----------------------------T-----YSRHNNEEKAQAIKFATIDSNIQL S.aureus_2 R-----------------------------T-----YSRHNNEEKAQAIKFATIDSNIQL L.brevis R-----------------------------A-----VDRHDRQDVAKAIKFTTIDSNLQL L.lactis R-----------------------------K-----INHQDKSDVARAVRFSTWDSNIQL S.cerevisiae_1 RLHDYDLKK-----------------------YGKVNARPSLSAIKYTLNYAYAELIISL S.cerevisiae_2 RLREYDIKNGHYLPDAND------------MDNNHDNYRPSYEAISETLHFTITELLISL S.cerevisiae_3 RLLDYDVKHGNYTVSEEQDKVKKSKSTEEIMEEKYFNYRPTNAAIKYCMKYSMVELSITL C.acetobutylicum_2 R----------------------------------QWNVEKEDVIKRQLRYEFLDTIISM S.enterica T-IAGFVNLAMMATAAAAFHFSGHTG-IADLDQAYLTLEPLLSHAAAT------VFGLSL S.typhimurium T-IAGFVNLAMMATAAAAFHFSGHTG-IADLDQAYLTLEPLLSHAAAT------VFGLSL E.coli T-IAGFVNLAMMATAAAAFHFSGHTG-VADLDEAYLTLQPLLSHAAAT------VFGLSL Y.pestis T-IAGFVNLAMMATAAAAFHFNGYEN-IAEIEEAYITLQPLLGNAAAT------VFGLSL D.radiodurans G-LAGLINMSMLAVAAATFHGKNVEN-AGDLTTAYQTLTPLLGPAASV------LFAVAL B.subtilis L-IAGAINASMLIVAAALFFKNGLF--VEDLDVAFQQFGHLVSPMSAA------LFGIGL C.acetobutylicum_1 N-IAFVVNAAMVIVSAAVFFKHGIK--VSTIEEAHRSLQPLLGNLSSG------AFGIAL M.bovis L-IAGGVNAAMLLVAALNMRGRGDT---ASIEGAYHAVHDTLGATIAV------LFAVGL M.tuberculosis L-IAGGVNAAMLLVAALNMRGRGDT---ASIEGAYHAVHDTLGATIAV------LFAVGL M.leprae T-IAGIVNTAMLLVAAINLQHHQVT---AYIEGTYTAIQDTLGATIAM------LFAIGL L.monocytogenes T-IALLINASILILAAAAFYTTGQ-HNVAGIEDAYKLLNPTLGSSIAS-----TVFAVAL L.innocua T-IALLINASILILAAAAFYTTGQ-HNVAGIEDAYKLLNPTLGSSIAS-----TVFAVAL Anabaena S-LALFINSAILIVSAATFHFSGN-QNVAEIQDAYKLLSPLLGVSAAS-----AIFGIAL A.tumefasciens M-FALLINASILILAAATFNKTGQ-TNVAELGEAHSLLAPLLGLAIAP-----TLFGVAL P.aeruginosa_1 T-LALLVNAAILIVAASVFHRNGH-TEVVDIEQAHALLSPLLGLELAS-----LLFAVAL X.fastidiosa M-LALFINASILILAAAVFHAQHH-FDVEEIEQAYQLLAPVLGVGVAA-----TLFATAL R.loti M-LALFVNAAILIVSAVAFHNTGH-QDVAEIDQAFELLSPLLGLGIAS-----ILFAVAL P.aeruginosa_2 S-LALLVNAAILILAAAAFHGSGH-TEVVEIQDAYHLLDPLVGGALAS-----FLFGFAL P.aeruginosa_3 S-LALLVNAAILILAAAAFHGSGH-TEVVEIQDAYHLLDPLVGGALAS-----FLFGFAL B.solanacearum S-LALLVNGAILVLAAAAFHANGH-QDVADIQDAHRLLEPIVGTAVAG-----VLFGIAL B.cepacia ------------------------------------------------------------ S.aureus_1 S-IAFVVNCLLLVLGASLFFNSNA-DDLGGFYDLYHALKTEPVLGATMGAIMSTLFAVAL S.aureus_2 S-IAFVVNCLLLVLGASLFFNSNA-DDLGGFYDLYHALKTEPVLGATMGAIMSTLFAVAL L.brevis T-IAFIVNSLLLILGAALFFGTNS-T-VGRFVDLFNSLNNSHIVGAIASPMLSMLFAVAL L.lactis T-VAFVVNSLLLIMGVAVFK-TG----V---IDDPSFFNHSFVDVD-------------- S.cerevisiae_1 FLIATFVNSAILIVAGATLSGQPE-AEDADLLSIYKLLVHYISPAAGL------IFALAM S.cerevisiae_2 FTVALFVNCAILIVSGATLYGSTQNAEEADLFSIYNLLCSTLSKGAGT------VFVLAL S.cerevisiae_3 FTLALFVNCAILVVAGSTLYNSPE-ADGADLFTIHELLSRNLAPAAGT------IFMLAL C.acetobutylicum_2 I-VGFAINSAMVLLAASTFFKMHVS--VSELSQAQALLKPLLGGSASV------VFALAL S.enterica VAAGLSSTVVGTLAGQVVMQGFVRFHIPLWVRRTIT----MLP-SFIVILMG---LDPTR S.typhimurium VAAGLSSTVVGTLAGQVVMQGFVRFHIPLWVRRTIT----MLP-SFIVILMG---LDPTR E.coli VAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVT----MLP-SFIVILMG---LDPTR Y.pestis IAAGLSSTVVGTLAGQVVMQGFVRFYIPMWVRRIVT----MLP-SFIVILAG---MDATQ D.radiodurans LASGLSSSAVGTMAGDVIMQGFMGFHIPLWLRRLIT----MLP-AFIVILLG---MDPSS B.subtilis LVAGLSSSSVGTLSGDVIMQGFINYRIPLYVRRFIT----IIP-PILIIASG---VNPTT C.acetobutylicum_1 LASGLSSSAVGTMAGQTIMKGFVNLSIPINLRRIIT----MLP-ALIIIALG---INPMR M.bovis LASGLASSSVGAYAGAMIMQGLLHWSVPMLVRRLIT----LGP-ALAILTLG---FDPTR M.tuberculosis LASGLASSSVGAYAGAMIMQGLLHWSVPMLVRRLIT----LGP-ALAILTLG---FDPTR M.leprae LASSLASASVGAYAGALIMQGLLQRSIPMLIRRLIT----LCP-AIAILALG---FDPTR L.monocytogenes LASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLLTRVLAIVPAVIITALYG--ANGINE L.innocua LASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLLTRVLAIVPAVIITALYG--ANGINE Anabaena LASGQSSTLTATLAGQIVMEGFLQFRLPSWLRRLITRLLAIIPALITIILFG--ENSTSS A.tumefasciens LCCGINSTVTATLAGQIVMEGFLKMRLAPWLRRLITRAIAIVPAAGVTIFYG--DSGTGQ P.aeruginosa_1 LASGLNSTVTTTLAGQIVMEGFLRLRLAPWARRLLTRGVAVLPVLLVTLLYG--EDGTAR X.fastidiosa LASGINSTVTATLAGQIVMEGFLRLRLRPWLRRVLTRGLAIVPVIVVVALYG--EQGTGR R.loti LASGLNSTVTATLAGQIIMEGFLRLRIPNWARRLLTRGLAIVPVVVVTALYG--EKGTGQ P.aeruginosa_2 LAAGQSSTFTGTIAGQVVMEGFLRAKIPCWQRRLITRGLALVPALIGVLWLG--EAAVGK P.aeruginosa_3 LAAGQSSTFTGTIAGQVVMEGFLRAKIPCWQRRLITRGLALVPALIGVLWLG--EAAVGK B.solanacearum LAAGQSSTFTGTIAGQILMEGFLELRIPCWQRRLATRALALIPAFVGVAMLG--DHAIGR B.cepacia ------------------------------------------------------------ S.aureus_1 LASGQNSTITGTLAGQIVMEGFLRLHIPNWLRRLITRSLAVIPVIVCLIIFKGNAAKIEQ S.aureus_2 LASGQNSTITGTLAGQIVMEGFLRLHIPNWLRRLITRSLAVIPVIVCLIIFKGNAAKIEQ L.brevis LSSGQSSTITGTLSGQIIMEGFIHLRMPLWAQRLLTRLLSVTPVLIFAIYYHGNEAKIEN L.lactis ------------------------------------------------------------ S.cerevisiae_1 LCSGQSAGIICTLAGQIVSEGFLQWSLPPWATRLCTRLIAIVPCLFVTLTMG--EKGISD S.cerevisiae_2 LFSGQSAGIVCTLSGQMVSEGFLNWTVSPALRRSATRAVAITPCLILVLVAG--RSGLSG S.cerevisiae_3 LLSGQSAGVVCTMSGQIVSEGHINWKLQPWQRRLATRCISIIPCLVISICIG--REALSK C.acetobutylicum_2 LFSGIASTVTAGMAGGSIFAGIYKEPYDIEDSHTQIG-VIITMVLAAVIIFF--IKDPFK S.enterica ILVMSQVLLSFGIALALVPLLIFTSNATLMGELVN------------------------- S.typhimurium ILVMSQVLLSFGIALALVPLLIFTSNATLMGELVN------------------------- E.coli ILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVN------------------------- Y.pestis ILVMSQVLLSFGIALALVPLLVFTGNKELMGELVD------------------------- D.radiodurans VLILSQVILCFGVPFALVPLLLFTARRDVMGALVT------------------------- B.subtilis ALVLSQVVLSFGIAFALIPLIMFTSNKRIMGSLIN------------------------- C.acetobutylicum_1 VLVLSQVALSFILPFPIIQMLLIAGRKDLMGILVN------------------------- M.bovis TLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTN------------------------- M.tuberculosis TLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTN------------------------- M.leprae ALVLSQIVLSFGIPFAVLPLVKLTNNRGLMGNDTN------------------------- L.monocytogenes LLIFSQVILSMQLSFAVIPLVMFTSDKQKMGEFV-------------------------- L.innocua LLIFSQVILSMQLSFAVIPLVMFTSDKQKMGEFV-------------------------- Anabaena LIVLSQVILSLQLPFAVIPLVMFTSNRRLMGEFV-------------------------- A.tumefasciens LLILTQVVLSLQLSFAVFPLVMFTSDKAKMGELR-------------------------- P.aeruginosa_1 LLIFSQVILSMQLPLAVIPLLQFVSDRRLMGPLA-------------------------- X.fastidiosa LLLLSQVILSMQLPFAVIPLLRCVADRKVMGALV-------------------------- R.loti LLVFSQVILSMQLPFAVVPLVQFVSDKKKMGNLA-------------------------- P.aeruginosa_2 LLVLSQVVLSLQLPFALWPLIRFSSDRGLMGEFV-------------------------- P.aeruginosa_3 LLVLSQVVLSLQLPFALWPLIRFSSDRGLMGEFV-------------------------- B.solanacearum LLVISQVVLGFQLPFAMFPLIRMTGDRALMGTFA-------------------------- B.cepacia ------------------------------------------------------------ S.aureus_1 LLVFSQVFLSIALPFCLIPLQLATSNKDLMGPFY-------------------------- S.aureus_2 LLVFSQVFLSIALPFCLIPLQLATSNKDLMGPFY-------------------------- L.brevis LLTLSQVFLSVALPFAIVPLVKFTSSKELMGEFV-------------------------- L.lactis ------------------------------------------------------------ S.cerevisiae_1 ILNFSQVVLSLILPIVSAPLIYFTANRKLMVVHD-ENGVVRAPADVNAIADETTP----- S.cerevisiae_2 ALNASQVVLSLLLPFVSAPLLYFTSSKKIMRVQLNRTKELSRTTDKKPVADRTEDDETIE S.cerevisiae_3 ALNASQVVLSIVLPFLVAPLIFFTCKKSIMKTEITVDHTEEDSHNHQNNNDRSAG----- C.acetobutylicum_2 GLIYSQMILSIQLPITIFTQIYLTSSKKVMGKFSN------------------------- S.enterica ---------------------------TRRVKQIGWIIVVLVVALNIWLLVGTVMGLS-- S.typhimurium ---------------------------TRRVKQVGWIIVVLVVALNIWLLVGTVMGLS-- E.coli ---------------------------SKRVKQTGWVIVVLVVALNIWLLVGTALGL--- Y.pestis ---------------------------TKTTQILGKLVVLIVVGLNAYLLISLL------ D.radiodurans ---------------------------RRSFTVIGWVIAVIIIALNGYLLWELLGG---- B.subtilis ---------------------------AKWITVVSWLIAVLIVALNVFLIVDTFR----- C.acetobutylicum_1 ---------------------------KKFTKIVGFIIATMIILLNIILLYLTFTGQT-- M.bovis ---------------------------HRATTWVGWVVAVMVSLLNVMLI---------- M.tuberculosis ---------------------------HRATTWVGWVVAVMVSLLNVMLIYLTVTG---- M.leprae ---------------------------HPATTVLGWAVAILVSLLNVVLIYLTVTS---- L.monocytogenes ------------N--------------PTWLKIISWAVAIFIAVLNIYLLFYTLTSL--- L.innocua ------------N--------------SPWLKIVSWSVAIFIAFLNIYLLFYTLTSL--- Anabaena ------------N--------------PLWLKSLAWLVAIVIVGLNAWLLLQSLWGWLLQ A.tumefasciens ------------S--------------PLWLSAIAWLIAVVIAALNVKLLMDFMG----- P.aeruginosa_1 ------------I--------------GAGTRWLAWAVALAIVGLNLQLLADFAFG---- X.fastidiosa ------------A--------------PRWLMVVAWLIAGVIVVLNVKLLGDYAVHLMVG R.loti ------------I--------------PRGVAALAWVVAAIILVLNFKLLYDTLFG--VG P.aeruginosa_2 ------------N--------------PRWVSALAWSLFGLISAANLTLLYFWFG----- P.aeruginosa_3 ------------N--------------PRWVSALAWSLFGLISAANLTLLYFWFG----- B.solanacearum ------------N--------------GRLTSAVAWCLFAVISVANLWLVWQVLAG---- B.cepacia ------------------------------------------------------------ S.aureus_1 ------------N--------------KTWVNIISWTLIIILSILNVYLIVQTFQELQS- S.aureus_2 ------------N--------------KTWVNIISWTLIIILSILNVYLIVQTFQELQS- L.brevis ------------N--------------KAWVKYSAWVATVVLVSLNIYLILQTVGVIG-- L.lactis ------------------------------------------------------------ S.cerevisiae_1 --------------LNSKHSKIVDFTNSRLLTYTSVFVWALIGSLNCYLVISYLLG-ADI S.cerevisiae_2 LEEMGIGSSSQERSLVSPAPEYKDMSNGMIVTVLAIIVWLIISGLNFYMLLGFTTG-KEV S.cerevisiae_3 -SVIEQDGSSGMEIENGKDVKIVYMANNWIITVIAIIVWLFLSLLNVYAIVQLGMSHGDI C.acetobutylicum_2 ---------------------------SLLDRVLLGIIAVIVTALNIALLVSYF------ S.enterica --- S.typhimurium --- E.coli --- Y.pestis --- D.radiodurans --- B.subtilis --- C.acetobutylicum_1 --- M.bovis --- M.tuberculosis --- M.leprae --- L.monocytogenes --- L.innocua --- Anabaena VPS A.tumefasciens --- P.aeruginosa_1 --- X.fastidiosa VSD R.loti --- P.aeruginosa_2 --- P.aeruginosa_3 --- B.solanacearum --- B.cepacia --- S.aureus_1 --- S.aureus_2 --- L.brevis --- L.lactis --- S.cerevisiae_1 HF- S.cerevisiae_2 HL- S.cerevisiae_3 S-- C.acetobutylicum_2 ---