RRTree is a program for relative-rate tests. It compares substitution rates between DNA or protein sequences grouped in phylogenetically defined lineages: Relative-Rate Tests with a tree.
RRTree is an inline program with no graphical interface, which can potentially run on any platform with a standard C compiler. You need an entry file of sequences (PHYLIP, CLUSTAL, MASE, NEXUS, GDE, or FASTA). To take phylogeny into account you also need a tree file in Newick format.