Pfam is a large collection of multiple sequence alignments and hidden Markov models covering many common protein domains and families. For each family in Pfam you can:
  Look at multiple alignments
  View protein domain architectures
  Examine species distribution
  Follow links to other databases
  View known protein structures

Pfam is a database of two parts, the first is the curated part of Pfam containing over 7868 protein families. To give Pfam a more comprehensive coverage of known proteins we automatically generate a supplement called Pfam-B. This contains a large number of small families taken from the PRODOM database that do not overlap with Pfam-A. Although of lower quality Pfam-B families can be useful when no Pfam-A families are found.

You can use Pfam on the platforms of Strasbourg, Pasteur Paris and Toulouse.