EST clustering and analysis - Significance of digital gene expression profiles
Transcription profiles, also called "Genetic Profiles" or "digital Northerns" are generated by partially sequencing thousands of randomly selected clones from relevant cDNA libraries. Differentially expressed genes can then be detected from variations in the counts of their cognate sequence tags (or "ESTs"). Genes differentially expressed in different tissues, during development, or during specific pathologies are of foremost interest to both basic and pharmaceutical research.
Here is provided a user-friendly interface to a program allowing a rigorous statistical analysis of digital transcription profiles data.