Proteic analysis - CysState
CysState is a program to predict the disulfide bonding state of cysteines of a protein given its amino-acid sequence. It is an implementation of the approach described in "Predicting the disulfide bonding state of cysteines using protein descriptors. Mucchielli-Giorgi M.-H., Hazout S., Tuffery P.; (2002) Proteins. 2002 46:243-9.
The approach was designed based on the hypothesis that we are focusing on protein intra-chain disulfide bonds. It was optimized on a set of proteins having at least 2 cysteines. This approach is not suited for the case of inter-chain disulfide bonds. Thus the sequences for which the prediction is performed should correspond to single chains, in which at least 2 cysteines occur, or the results might be meaningless.