| delta.calculate | Calculates the rank-based test statistic for Y and S and the difference, delta |
| delta.calculate.extension | Calculate Delta: Difference in Rank-based Statistics for Two Outcomes |
| delta.reml.meta | Function to perform meta-analysis of summary statistics and hypothesis testing for a single marker |
| est.power | Estimated power to detect a valid surrogate |
| example.data | Example data |
| example.data.highdim | High‑dimensional surrogate candidate example dataset |
| example.data.highdim.multistudy | High-dimensional, multi-study surrogate candidate example dataset |
| example.data.highdim.multistudy.ipd | High‑dimensional multi-study individual participant surrogate candidate example dataset |
| generate.example.data.highdim | Generate individual participant data for high-dimensional surrogate candidates and response |
| generate.example.data.highdim.multistudy | Generate high-dimensional multi-study surrogate marker trial-level effects |
| generate.example.data.highdim.multistudy.ipd | Generate multi-study individual participant data for high-dimensional surrogate candidates and response |
| rise.evaluate | Function to perform the evaluation stage of RISE : Two-Stage Rank-Based Identification of High-Dimensional Surrogate Markers |
| rise.evaluate.meta | Function to perform the evaluation stage of RISE-meta : Meta-Analysis of High-Dimensional Surrogate Markers |
| rise.screen | Function to perform the screening stage of RISE : Two-Stage Rank-Based Identification of High-Dimensional Surrogate Markers |
| rise.screen.meta | Function to perform the screening stage of RISE-meta : Meta-Analysis of High-Dimensional Surrogate Markers |
| test.surrogate | Tests whether the surrogate is valid |
| test.surrogate.extension | Function to test for trial-level surrogacy of a single marker extended to the paired, two sided test setting |
| test.surrogate.rise | Function to perform RISE : Two-Stage Rank-Based Identification of High-Dimensional Surrogate Markers |