Sigmoidal model fitting, optimal model selection and calculation of various features that are essential in the analysis of quantitative real-time polymerase chain reaction (qPCR), according to Ritz & Spiess (2008) <doi:10.1093/bioinformatics/btn227> and Spiess et al. (2008) <doi:10.1186/1471-2105-9-221>.

Computes normalized cycle threshold (Ct) values (delta Ct) from raw quantitative polymerase 
    chain reaction (qPCR) Ct values and conducts test of significance using t.test(). Plots expression 
    values based from log2(2^(-1*delta delta Ct)) across groups per gene of interest. Methods for calculation
    of delta delta Ct and relative expression (2^(-1*delta delta Ct)) values are described in: 
    Livak & Schmittgen, (2001) <doi:10.1006/meth.2001.1262>.

Content-preserving transformations transformations of PDF files such 
    as split, combine, and compress. This package interfaces directly to the 'qpdf' 
    C++ library <https://qpdf.sourceforge.io/> and does not require any command 
    line utilities. Note that 'qpdf' does not read actual content from PDF files: 
    to extract text and data you need the 'pdftools' package.

Provides functions for estimating ploidy levels and detecting aneuploidy in individuals using 
             allele intensities or allele count data from high-throughput genotyping platforms, including 
             single nucleotide polymorphism (SNP) arrays and sequencing-based technologies. Implements an extended version of the 'PennCNV' 
             signal standardization method by Wang et al. (2007) <doi:10.1101/gr.6861907> for higher ploidy 
             levels. Computes B-allele frequencies (BAF), z-scores, and identifies copy number variation patterns.

Efficiently solve quadratic problems with linear inequality, equality and box constraints. The method used is outlined in D. Goldfarb, and A. Idnani (1983) <doi:10.1007/BF02591962>.

Computes noncompartmental pharmacokinetic parameters
 for drug concentration profiles.  For each profile, data
 imputations and adjustments are made as necessary and
 basic parameters are estimated. Supports single dose, multi-dose,
 and multi-subject data.  Supports steady-state calculations
 and various routes of drug administration. See ?qpNCA and vignettes.
 Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), 
 Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and
 Gibaldi and Perrier (1982, ISBN:978-0824710422).