Provides functions to construct two-phase design layouts, compute treatment- and block-incidence matrices, derive C-matrices for residual, direct, and interaction effects, and calculate the efficiency factor for two-phase experimental designs with factorial treatment structure.

We described a novel Topology-based pathway enrichment analysis, which integrated the global position of the nodes and the topological property of the pathways in  Kyoto Encyclopedia of Genes and Genomes Database.
             We also provide some functions to obtain the latest information about pathways to finish pathway enrichment analysis using this method.

A bioinformatics tool for the estimation of the tumor purity from sequencing data. 
    It uses the set of putative clonal somatic single nucleotide variants within copy number neutral
    segments to call tumor cellularity.

Calculates the number of true positives and false positives from a dataset formatted for Jackknife alternative free-response receiver operating characteristic which is used for statistical analysis which is explained in the book 'Chakraborty' 'DP' (2017), "Observer Performance Methods for Diagnostic Imaging - Foundations, Modeling, and Applications with R-Based Examples", Taylor-Francis <https://www.crcpress.com/9781482214840>.

Uses thresholded partial least squares algorithm to create a regression or classification model. For more information, see Lee, Bradlow, and Kable <doi:10.1016/j.crmeth.2022.100227>.

A traceability focused tool created to simplify the data manipulation necessary to create clinical summaries.

Contains functions for calculating the Federal Highway Administration (FHWA) Transportation Performance Management (TPM) performance measures. Currently, the package provides methods for the System Reliability and Freight (PM3) performance measures calculated from travel time data provided by The National Performance Management Research Data Set (NPMRDS), including Level of Travel Time Reliability (LOTTR), Truck Travel Time Reliability (TTTR), and Peak Hour Excessive Delay (PHED) metric scores for calculating statewide reliability performance measures. Implements <https://www.fhwa.dot.gov/tpm/guidance/pm3_hpms.pdf>.