Provides a comprehensive framework for model fitting and simulation
    of drug release kinetics, pharmacokinetics (PK), and pharmacodynamics (PD).
    The package implements widely used mechanistic and empirical models for in
    vitro drug release, including zero-order, first-order, Higuchi,
    Korsmeyer-Peppas, Hixson-Crowell, and Weibull models. Pharmacokinetic
    functionality includes linear and nonlinear functions for one- and
    two-compartment models for intravenous bolus and oral administration,
    Michaelis-Menten kinetics, and non-compartmental analysis (NCA).
    Pharmacodynamic and dose-response modeling is supported through Emax-based
    models, including stimulatory (sigmoid Emax) and inhibitory (sigmoid Imax)
    Hill models, four- and five-parameter logistic models, as well as median
    toxic dose (TD50) and lethal dose (LD50) models. The package is intended to
    support parameter estimation, simulation, and model comparison in
    pharmaceutical research, drug development, and pharmacometrics education.
    For more details, see Gabrielsson & Weiner (2000) <ISBN:9186274929>,
    Holford & Sheiner (1981) <doi:10.2165/00003088-198106060-00002>, and
    Manlapaz (2025) <doi:10.32614/CRAN.package.adsoRptionCMF>.

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD)
        models described by differential equation (DE) systems. Simulation using 
        ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) 
        <doi:10.1016/j.vascn.2015.03.004>).

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software.
             Some features are
             1) CDISC SDTM terms
             2) Automatic slope selection with the same criterion of WinNonlin(R)
             3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method
             4) Interval(partial) AUCs with 'linear' or 'log' interpolation method
             * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).