Tools for advanced analysis of continuous glucose monitoring (CGM)
    time-series, implementing GRID (Glucose Rate Increase Detector) and GRID-based
    algorithms for postprandial peak detection, and detection of hypoglycemic and
    hyperglycemic episodes (Levels 1/2/Extended) aligned with international consensus
    CGM metrics. Core algorithms are implemented in optimized C++ using 'Rcpp' to
    provide accurate and fast analysis on large datasets.

Evaluates predictive performance under feature-level missingness in repeated-measures continuous glucose monitoring-like data. The benchmark injects missing values at user-specified rates, imputes incomplete feature matrices using an iterative chained-equations approach inspired by multivariate imputation by chained equations (MICE; Azur et al. (2011) <doi:10.1002/mpr.329>), fits Random Forest regression models (Breiman (2001) <doi:10.1023/A:1010933404324>) and k-nearest-neighbor regression models (Zhang (2016) <doi:10.21037/atm.2016.03.37>), and reports mean absolute percentage error and R-squared across missingness rates.

Continuous glucose monitoring (CGM) systems provide real-time, 
  dynamic glucose information by tracking interstitial glucose values 
  throughout the day. Glycemic variability, also known as glucose variability, 
  is an established risk factor for hypoglycemia (Kovatchev) and 
  has been shown to be a risk factor in diabetes complications. 
  Over 20 metrics of glycemic variability have been identified. 
  Here, we provide functions to calculate glucose summary metrics, 
  glucose variability metrics (as defined in clinical publications), 
  and visualizations to visualize trends in CGM data.
  Cho P, Bent B, Wittmann A, et al. (2020) <https://diabetes.diabetesjournals.org/content/69/Supplement_1/73-LB.abstract>
  American Diabetes Association (2020) <https://professional.diabetes.org/diapro/glucose_calc>
  Kovatchev B (2019) <doi:10.1177/1932296819826111>
  Kovdeatchev BP (2017) <doi:10.1038/nrendo.2017.3>
  Tamborlane W V., Beck RW, Bode BW, et al. (2008) <doi:10.1056/NEJMoa0805017>
  Umpierrez GE, P. Kovatchev B (2018) <doi:10.1016/j.amjms.2018.09.010>.