In some phase I trials, the design goal is to find the dose associated with a certain target toxicity rate or the dose with a certain weighted sum of rates of various toxicity grades. 'TITEgBOIN' provides the set up and calculations needed to run a dose-finding trial using bayesian optimal interval (BOIN) (Yuan et al. (2016) <doi:10.1158/1078-0432.CCR-16-0592>), generalized bayesian optimal interval (gBOIN) (Mu et al. (2019) <doi:10.1111/rssc.12263>), time-to-event bayesian optimal interval (TITEBOIN) (Lin et al. (2020) <doi:10.1093/biostatistics/kxz007>) and time-to-event generalized bayesian optimal interval (TITEgBOIN) (Takeda et al. (2022) <doi:10.1002/pst.2182>) designs. 'TITEgBOIN' can conduct tasks: run simulations and get operating characteristics; determine the dose for the next cohort; select maximum tolerated dose (MTD). These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose limiting toxicity (DLT) rates or target normalized equivalent toxicity score (ETS) rates to account for discrete toxicity score, and incorporate safety and/or stopping rules.

Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.

A collection of functions to plot acid/base titration 
    curves (pH vs. volume of titrant), complexation titration curves 
    (pMetal vs. volume of EDTA), redox titration curves (potential 
    vs.volume of titrant), and precipitation titration curves (either 
    pAnalyte or pTitrant vs. volume of titrant). Options include the 
    titration of mixtures, the ability to overlay two or more 
    titration curves, and the ability to show equivalence points.

Specialized toolkit for processing biological and fisheries data from Peru's anchovy (Engraulis ringens) fishery. Provides functions to analyze fishing logbooks, calculate biological indicators (length-weight relationships, juvenile percentages), generate spatial fishing indicators, and visualize regulatory measures from Peru's Ministry of Production. Features automated data processing from multiple file formats, coordinate validation, spatial analysis of fishing zones, and tools for analyzing fishing closure announcements and regulatory compliance. Includes built-in datasets of Peruvian coastal coordinates and parallel lines for analyzing fishing activities within regulatory zones.