Calculates empirical TL-moments (trimmed L-moments) of arbitrary 
    order and trimming, and converts them to distribution parameters.

Implementation of the classic Genz algorithm and a novel tile-low-rank algorithm for computing	relatively high-dimensional multivariate normal (MVN) and Student-t (MVT) probabilities. 
	References used for this package:
	Foley, James, Andries van Dam, Steven Feiner, and John Hughes. 
	"Computer Graphics: Principle and Practice". Addison-Wesley 
	Publishing Company. Reading, Massachusetts (1987, ISBN:0-201-84840-6 1);
	Genz, A., "Numerical computation of multivariate
	normal probabilities," Journal of Computational and
	Graphical Statistics, 1, 141-149 (1992) <doi:10.1080/10618600.1992.10477010>;
    Cao, J., Genton, M. G., Keyes, D. E., & Turkiyyah, G. M. "Exploiting Low
    Rank Covariance Structures for Computing High-Dimensional Normal and Student-
    t Probabilities," Statistics and Computing, 31.1, 1-16 (2021) 
    <doi:10.1007/s11222-020-09978-y>;
    Cao, J., Genton, M. G., Keyes, D. E., & Turkiyyah, G. M. "tlrmvnmvt: 
    Computing High-Dimensional Multivariate Normal and Student-t Probabilities 
    with Low-Rank Methods in R," Journal of Statistical Software, 101.4, 
    1-25 (2022) <doi:10.18637/jss.v101.i04>.

Functions for point and interval estimation in
	     error-in-variables models via total least squares or
	     generalized total least squares method. See Golub and Van
	     Loan (1980) <doi:10.1137/0717073>, Gleser (1981)
	     <https://www.jstor.org/stable/2240867>, Ivan Markovsky
	     and Huffel (2007) <doi:10.1016/j.sigpro.2007.04.004> for
	     more information.

Fast, reproducible detection and quantitative analysis of tertiary lymphoid structures (TLS) in multiplexed tissue imaging. Implements Independent Component Analysis Trace (ICAT) index, local Ripley's K scanning, automated K Nearest Neighbor (KNN)-based TLS detection, and T-cell clusters identification as described in Amiryousefi et al. (2025) <doi:10.1101/2025.09.21.677465>.