The distributed online expectation maximization algorithms are used to solve parameters of Poisson mixture models. The philosophy of the package is described in Guo, G. (2022) <doi:10.1080/02664763.2022.2053949>.

'CRAN' packages 'DoE.base' and 'Rmosek' and non-'CRAN' package 'gurobi' are enhanced with functionality for the creation of optimized arrays for experimentation, where optimization is in terms of generalized minimum aberration. It is also possible to optimally extend existing arrays to larger run size. The package writes 'MPS' (Mathematical Programming System) files for use with any mixed integer optimization software that can process such files. If at least one of the commercial products 'Gurobi' or 'Mosek' (free academic licenses available for both) is available, the package also creates arrays by optimization. For installing 'Gurobi' and its R package 'gurobi', follow instructions at <https://support.gurobi.com/hc/en-us/articles/14462206790033-How-do-I-install-Gurobi-for-R>. For installing 'Mosek' and its R package 'Rmosek', follow instructions at <https://www.mosek.com/downloads/> and <https://docs.mosek.com/8.1/rmosek/install-interface.html>, or use the functionality in the stump CRAN R package 'Rmosek'.

Rare variant association test integrating variant position information. It aims to identify the presence of clusters of disease-risk variants in specific gene regions. For more details, please read the publication from Persyn et al. (2017)  <doi:10.1371/journal.pone.0179364>.

Various kinds of designs for
 (industrial) experiments can be created. The package uses, and sometimes enhances,
        design generation routines from other packages. 
        So far, response surface designs from package 'rsm', Latin hypercube
        samples from packages 'lhs' and 'DiceDesign', and 
        D-optimal designs from package 'AlgDesign' have been implemented.

The 'future' package provides a unifying parallelization framework for R that supports many parallel and distributed backends <doi:10.32614/RJ-2021-048>. The 'foreach' package provides a powerful API for iterating over an R expression in parallel. The 'doFuture' package brings the best of the two together. There are two alternative ways to use this package. The recommended approach is to use 'y <- foreach(...) %dofuture% { ... }', which does not require using 'registerDoFuture()' and has many advantages over '%dopar%'. The alternative is the traditional 'foreach' approach by registering the 'foreach' adapter 'registerDoFuture()' and so that 'y <- foreach(...) %dopar% { ... }' runs in parallelizes with the 'future' framework.