A shortcut procedure is proposed to implement closed testing for large-scale multiple testings, especially with the global test. This shortcut is asymptotically equivalent to closed testing and post hoc. Users could detect any possible sets of features or pathways with family-wise error rate controlled. The global test is powerful to detect associations between a group of features and an outcome of interest.

Retrieves historical versions of clinical trial registry
    entries from <https://ClinicalTrials.gov>. Package functionality
    and implementation for v 1.0.0 is documented in Carlisle (2022)
    <DOI:10.1371/journal.pone.0270909>.

Estimation and inference methods for the continuous threshold expectile regression.
    It can fit the continuous threshold expectile regression and test the existence of change point,
    for the paper, "Feipeng Zhang and Qunhua Li (2016). A continuous threshold expectile regression, submitted."

Identification and network inference of genetic loci associated
  with correlation changes in quantitative traits (called correlated trait loci, CTLs).
  Arends et al. (2016) <doi:10.21105/joss.00087>.

Estimation of Markov generator matrices from discrete-time observations. The implemented approaches comprise diagonal and weighted adjustment of matrix logarithm based candidate solutions as in Israel (2001) <doi:10.1111/1467-9965.00114> as well as a quasi-optimization approach. Moreover, the expectation-maximization algorithm and the Gibbs sampling approach of Bladt and Sorensen (2005) <doi:10.1111/j.1467-9868.2005.00508.x> are included.

Software to facilitates taking movement data in xyt format and pairing it with raster covariates within a continuous time Markov chain (CTMC) framework.  As described in Hanks et al. (2015) <DOI:10.1214/14-AOAS803> , this allows flexible modeling of movement in response to covariates (or covariate gradients) with model fitting possible within a Poisson GLM framework.

Computes effect sizes, standard errors, and confidence intervals
    for total, direct, and indirect effects in continuous-time mediation models
    as described in Pesigan, Russell, and Chow (2025) <doi:10.1037/met0000779>.