A collection of functions and 'jamovi' module for the estimation approach to inferential statistics, the approach which emphasizes effect sizes, interval estimates, and meta-analysis. Nearly all functions are based on 'statpsych' and 'metafor'.  This package is still under active development, and breaking changes are likely, especially with the plot and hypothesis test functions.  Data sets are included for all examples from Cumming & Calin-Jageman (2024) <ISBN:9780367531508>.

The experiment selector cross-validated targeted maximum likelihood estimator (ES-CVTMLE) aims to select the experiment that optimizes the bias-variance tradeoff for estimating a causal average treatment effect (ATE) where different experiments may include a randomized controlled trial (RCT) alone or an RCT combined with real-world data. Using cross-validation, the ES-CVTMLE separates the selection of the optimal experiment from the estimation of the ATE for the chosen experiment. The estimated bias term in the selector is a function of the difference in conditional mean outcome under control for the RCT compared to the combined experiment. In order to help include truly unbiased external data in the analysis, the estimated average treatment effect on a negative control outcome may be added to the bias term in the selector. For more details about this method, please see Dang et al. (2022) <arXiv:2210.05802>.

Software of 'esDesign' is developed to implement the adaptive 
    enrichment designs with sample size re-estimation presented in 
    Lin et al. (2021) <doi: 10.1016/j.cct.2020.106216>. In details, 
    three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR),
    AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package 
    also contains several widely used adaptive designs, such as the Marker 
    Sequential Test (MaST) design proposed Freidlin et al. 
    (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs 
    without early stopping (AED or ES), the sample size re-estimation 
    procedure (SSR) based on the conditional power proposed by 
    Proschan and Hunsberger (1995), and some useful functions. 
    In details, we can calculate the futility and/or efficacy stopping 
    boundaries, the sample size required, calibrate the value of the threshold 
    of the difference between subgroup-specific test statistics, conduct the 
    simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.