Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.

A collection of functions to plot acid/base titration 
    curves (pH vs. volume of titrant), complexation titration curves 
    (pMetal vs. volume of EDTA), redox titration curves (potential 
    vs.volume of titrant), and precipitation titration curves (either 
    pAnalyte or pTitrant vs. volume of titrant). Options include the 
    titration of mixtures, the ability to overlay two or more 
    titration curves, and the ability to show equivalence points.

Specialized toolkit for processing biological and fisheries data from Peru's anchovy (Engraulis ringens) fishery. Provides functions to analyze fishing logbooks, calculate biological indicators (length-weight relationships, juvenile percentages), generate spatial fishing indicators, and visualize regulatory measures from Peru's Ministry of Production. Features automated data processing from multiple file formats, coordinate validation, spatial analysis of fishing zones, and tools for analyzing fishing closure announcements and regulatory compliance. Includes built-in datasets of Peruvian coastal coordinates and parallel lines for analyzing fishing activities within regulatory zones.

Facilitate the management of data from knowledge
   resources that are frequently used alone or together
   in research environments.
   In 'TKCat', knowledge resources are manipulated as modeled database (MDB)
   objects. These objects provide access to the data tables along with a general
   description of the resource and a detail data model documenting the
   tables, their fields and their relationships.
   These MDBs are then gathered in catalogs that can be easily
   explored an shared.
   Finally, 'TKCat' provides tools to easily subset, filter and combine MDBs and
   create new catalogs suited for specific needs.