Non-parametric tests (Wilcoxon rank sum test and Wilcoxon signed rank test)
       for clustered data documented in
       Jiang et. al (2020) <doi:10.18637/jss.v096.i06>.

Statistical methods for ROC surface analysis in three-class classification problems for clustered data and in presence of covariates. In particular, the package allows to obtain covariate-specific point and interval estimation for:
  (i) true class fractions (TCFs) at fixed pairs of thresholds;
  (ii) the ROC surface;
  (iii) the volume under ROC surface (VUS);
  (iv) the optimal pairs of thresholds.
  Methods considered in points (i), (ii) and (iv) are proposed and discussed in To et al. (2022) <doi:10.1177/09622802221089029>. Referring to point (iv), three  different selection criteria are implemented: Generalized Youden Index (GYI), Closest to Perfection (CtP) and Maximum Volume (MV). Methods considered in point (iii) are proposed and discussed in Xiong et al. (2018) <doi:10.1177/0962280217742539>. Visualization tools are also provided. We refer readers to the articles cited above for all details.

Implements a new method 'ClussCluster' descried in Ge Jiang and Jun Li, "Simultaneous Detection of Clusters and Cluster-Specific Genes in High-throughput Transcriptome Data" (Unpublished).
	Simultaneously perform clustering analysis and signature 	gene selection on high-dimensional transcriptome data sets. 	To do so, 'ClussCluster' incorporates a Lasso-type 	regularization penalty term to the objective function of K-	means so that cell-type-specific signature genes can be 	identified while clustering the cells.

Evaluates the stability and significance of clusters on 'igraph' graphs.
    Supports weighted and unweighted graphs. Implements the cluster evaluation methods
    defined by Arratia A, Renedo M (2021) <doi:10.7717/peerj-cs.600>. Also includes an
    implementation of the Reduced Mutual Information introduced by Newman et al. (2020) 
    <doi:10.1103/PhysRevE.101.042304>.

A set of tools for evaluating clustering robustness using 
    proportion of ambiguously clustered pairs (Senbabaoglu et al. (2014) 
    <doi:10.1038/srep06207>), as well as similarity across methods 
    and method stability using element-centric clustering comparison (Gates et 
    al. (2019) <doi:10.1038/s41598-019-44892-y>). Additionally, this package 
    enables stability-based parameter assessment for graph-based clustering 
    pipelines typical in single-cell data analysis.