Functions for the management and treatment of hydrology and 
  meteorology time-series stored in a 'Sqlite' data base.

A novel decision tree algorithm in the hypothesis testing framework. The algorithm examines the distribution difference between two child nodes over all possible binary partitions. The test statistic of the hypothesis testing is equivalent to the generalized energy distance, which enables the algorithm to be more powerful in detecting the complex structure, not only the mean difference. It is applicable for numeric, nominal, ordinal explanatory variables and the response in general metric space of strong negative type. The algorithm has superior performance compared to other tree models in type I error, power, prediction accuracy, and complexity.

High throughput toxicokinetics ("HTTK") is the 
             combination of 1) chemical-specific in vitro measurements or in
             silico predictions and 2) generic mathematical models, to
             predict absorption, distribution, metabolism, and excretion by the
             body. HTTK methods have been described by Pearce et al. (2017) 
             (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
             Here we provide examples (vignettes) applying HTTK to solve various
             problems in bioinformatics, toxicology, and exposure science.
             In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
             whenever a new HTTK model is developed, the code to generate the 
             figures evaluating that model is added as a new vignettte.

In order to improve performance for HTTP API clients, 'httpcache'
    provides simple tools for caching and invalidating cache. It includes the
    HTTP verb functions GET, PUT, PATCH, POST, and DELETE, which are drop-in
    replacements for those in the 'httr' package. These functions are cache-aware
    and provide default settings for cache invalidation suitable for RESTful
    APIs; the package also enables custom cache-management strategies.
    Finally, 'httpcache' includes a basic logging framework to facilitate the
    measurement of HTTP request time and cache performance.