Response surface methods for drug synergy analysis. Available
    methods include generalized and classical Loewe formulations as well as Highest
    Single Agent methodology. Response surfaces can be plotted in an interactive
    3-D plot and formal statistical tests for presence of synergistic effects are
    available. Implemented methods and tests are described in the article 
    "BIGL: Biochemically Intuitive Generalized Loewe null model for prediction 
    of the expected combined effect compatible with partial agonism and antagonism"
    by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas, 
    Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017) 
    <doi:10.1038/s41598-017-18068-5>.

Extend lasso and elastic-net model fitting for large data sets that
  cannot be loaded into memory. Designed to be more memory- and
  computation-efficient than existing lasso-fitting packages like 'glmnet' and
  'ncvreg', thus allowing the user to analyze big data with limited RAM
  <doi:10.32614/RJ-2021-001>.

Calculation of physical (e.g. aerodynamic conductance, surface temperature), 
             and physiological (e.g. canopy conductance, water-use efficiency) ecosystem properties
			 from eddy covariance data and accompanying meteorological measurements. Calculations
			 assume the land surface to behave like a 'big-leaf' and return bulk ecosystem/canopy variables.

Regression for data too large to fit in memory.

Regression for data too large to fit in memory. This package functions exactly like the 'biglm' package, but works with later versions of R.

Implements optimal matching with near-fine balance in large observational studies with the use of optimal calipers to get a sparse network. The caliper is optimal in the sense that it is as small as possible such that a matching exists. The main functions in the 'bigmatch' package are optcal() to find the optimal caliper, optconstant() to find the optimal number of nearest neighbors, and nfmatch() to find a near-fine balance match with a caliper and a restriction on the number of nearest neighbors. 
    Yu, R., Silber, J. H., and Rosenbaum, P. R. (2020). <DOI:10.1214/19-sts699>.