Augments existing or de-novo cell-type signature matrices to deconvolve bulk gene expression data This package expands on the techniques outlined in Newman et al.’s 2015 Nature Methods paper: ‘Robust enumeration of cell subsets from tissue expression profiles’. to allow a user to easily add their own cell types (e.g. a tumor specific cell type) to Newman’s LM22 or other signature matrix.

To install this package in R, use devtools.




Data for the Vignette can be found at sdanzige/ADAPTSdata, sdanziger/ADAPTSdata2, sdanziger/ADAPTSdata3 and yxinyi2/ADAPTSdata4

More information about this package is available on bioRxiv ( and this package has been officially released as an R package on CRAN (