MRmediation: A Causal Mediation Method with Methylated Region (MR) as the
Mediator
A causal mediation approach under the counterfactual framework
to test the significance of total, direct and indirect effects. In this approach,
a group of methylated sites from a predefined region are utilized as the mediator,
and the functional transformation is used to reduce the possible high dimension
in the region-based methylated sites and account for their location information.
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