upndown: Utilities and Design Aids for Up-and-Down Dose-Finding Studies

Up-and-Down (UD) is the most popular design approach to dose-finding, but it has been severely under-served by the statistical and computing communities. This is the first package that comprehensively addresses UD's needs. Development version available on Github: assaforon/upndown. Recent applied UD tutorial: Oron et al., 2022 <doi:10.1097/ALN.0000000000004282>. Recent methodological overview: Oron and Flournoy, 2025 <doi:10.51387/24-NEJSDS74>.

Version:	1.0.0
Imports:	cir, expm, MASS, plyr
Suggests:	knitr, rmarkdown
Published:	2026-11-13
DOI:	10.32614/CRAN.package.upndown
Author:	Assaf P. Oron [cre, aut]
Maintainer:	Assaf P. Oron <assaf.oron at gmail.com>
License:	GPL-2
NeedsCompilation:	no
CRAN checks:	upndown results

Documentation:

Reference manual:	upndown.html , upndown.pdf
Vignettes:	'upndown' Package Vignette 1: Up-and-Down Basics (source, R code)

Downloads:

Package source:	upndown_1.0.0.tar.gz
Windows binaries:	r-devel: upndown_0.3.0.zip, r-release: upndown_0.3.0.zip, r-oldrel: upndown_0.3.0.zip
macOS binaries:	r-release (arm64): upndown_1.0.0.tgz, r-oldrel (arm64): upndown_1.0.0.tgz, r-release (x86_64): upndown_1.0.0.tgz, r-oldrel (x86_64): upndown_1.0.0.tgz
Old sources:	upndown archive

Linking:

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