(data stored in ACNUC941 zone)

SWISSPROT: A2BHA3_DANRE

ID   A2BHA3_DANRE            Unreviewed;       381 AA.
AC   A2BHA3;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 91.
DE   SubName: Full=Creatine kinase, muscle a {ECO:0000313|Ensembl:ENSDARP00000037871};
GN   Name=ckma {ECO:0000313|Ensembl:ENSDARP00000037871,
GN   ECO:0000313|ZFIN:ZDB-GENE-980526-109};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000037871, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000037871, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000037871,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000037871}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000037871};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000155256}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000155256};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU00843,
CC       ECO:0000256|RuleBase:RU000505, ECO:0000256|SAAS:SAAS00872957}.
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DR   EMBL; BX547938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_571007.2; NM_130932.2.
DR   STRING; 7955.ENSDARP00000037871; -.
DR   PaxDb; A2BHA3; -.
DR   Ensembl; ENSDART00000032481; ENSDARP00000037871; ENSDARG00000035327.
DR   Ensembl; ENSDART00000183188; ENSDARP00000155256; ENSDARG00000114671.
DR   GeneID; 30095; -.
DR   KEGG; dre:30095; -.
DR   CTD; 30095; -.
DR   ZFIN; ZDB-GENE-980526-109; ckma.
DR   eggNOG; KOG3581; Eukaryota.
DR   eggNOG; COG3869; LUCA.
DR   GeneTree; ENSGT00950000182772; -.
DR   HOGENOM; HOG000232165; -.
DR   InParanoid; A2BHA3; -.
DR   KO; K00933; -.
DR   OMA; GNTHNNF; -.
DR   OrthoDB; 825025at2759; -.
DR   TreeFam; TF314214; -.
DR   Proteomes; UP000000437; Chromosome 5.
DR   Bgee; ENSDARG00000035327; Expressed in 33 organ(s), highest expression level in bone tissue.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.135.10; -; 1.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR036802; ATP-guanido_PTrfase_N_sf.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   PANTHER; PTHR11547; PTHR11547; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; SSF48034; 1.
DR   SUPFAM; SSF55931; SSF55931; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
PE   1: Evidence at protein level;
DR   PRODOM; A2BHA3.
DR   SWISS-2DPAGE; A2BHA3.
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00843,
KW   ECO:0000256|SAAS:SAAS00872938};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Kinase {ECO:0000256|PROSITE-ProRule:PRU00843,
KW   ECO:0000256|RuleBase:RU000505, ECO:0000256|SAAS:SAAS00872936};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00843,
KW   ECO:0000256|SAAS:SAAS00872945};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2BHA3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00843,
KW   ECO:0000256|RuleBase:RU000505, ECO:0000256|SAAS:SAAS00872952}.
FT   DOMAIN       11     98       Phosphagen kinase N-terminal.
FT                                {ECO:0000259|PROSITE:PS51509}.
FT   DOMAIN      125    367       Phosphagen kinase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51510}.
FT   NP_BIND     128    132       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00843}.
FT   NP_BIND     292    296       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00843}.
FT   NP_BIND     320    325       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00843}.
FT   BINDING     191    191       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00843}.
FT   BINDING     236    236       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00843}.
SQ   SEQUENCE   381 AA;  42815 MW;  D05BA53B83099FD9 CRC64;
     MPFGNTHNNF KLNYSVDEEY PDLSKHNNHM AKVLTKEMYG KLRDKQTSTG FTVDDVIQTG
     VDNPGHPFIM TVGCVAGDEE SYEVFKDLFD PVISDRHGGY KATDKHKTDL NFENLKGGDD
     LDPNYVLSSR VRTGRSIKGY ALPPHNSRGE RRAVEKLSVE ALSSLDGEFK GKYYPLKSMT
     DAEQEQLIAD HFLFDKPVSP LLLAAGMARD WPDARGIWHN ENKTFLVWVN EEDHLRVISM
     QKGGNMKEVF KRFCVGLQRI EEIFKKHNHG FMWNEHLGFV LTCPSNLGTG LRGGVHVKLP
     KLSTHAKFEE ILTRLRLQKR GTGGVDTASV GGVFDISNAD RIGSSEVEQV QCVVDGVKLM
     VEMEKKLEKG ESIDSMIPAQ K
//

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