(data stored in ACNUC941 zone)

HOGENOM: BOVIN21_71_PE2

ID   BOVIN21_71_PE2                       STANDARD;      PRT;   381 AA.
AC   BOVIN21_71_PE2; Q5EA61;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase B-type; EC=2.7.3 2;AltName:
DE   Full=B-CK;AltName: Full=Creatine kinase B chain; (BOVIN21_71.PE2).
GN   Name=CKB;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN21_71.PE2.
CC       Bos taurus chromosome 21 Btau_4.0 partial sequence 68193314..69173390
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRB_BOVIN
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000035998;ENSBTAT00000050490;ENSBTAP00000047181.
DR   EMBL; AF207866; - ;
DR   EMBL; BC102333; - ;
DR   EMBL; BT020708; - ;
DR   UniProtKB/Swiss-Prot; Q5EA61; -.
DR   EMBL; BT020708; AAX08725.1; -; mRNA.
DR   EMBL; BC102333; AAI02334.1; -; mRNA.
DR   IPI; IPI00716827; -.
DR   RefSeq; NP_001015613.1; NM_001015613.1.
DR   UniGene; Bt.88935; -.
DR   ProteinModelPortal; Q5EA61; -.
DR   SMR; Q5EA61; 2-381.
DR   STRING; Q5EA61; -.
DR   PRIDE; Q5EA61; -.
DR   Ensembl; ENSBTAT00000050490; ENSBTAP00000047181; ENSBTAG00000035998.
DR   GeneID; 516210; -.
DR   KEGG; bta:516210; -.
DR   CTD; 1152; -.
DR   eggNOG; maNOG04306; -.
DR   InParanoid; Q5EA61; -.
DR   OrthoDB; EOG4R7V9X; -.
DR   GO; GO:0005739; C:mitochondrion; ISS:AgBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; IEA:EC.
DR   GO; GO:0007420; P:brain development; ISS:AgBase.
DR   GO; GO:0030644; P:cellular chloride ion homeostasis; ISS:AgBase.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; BOVIN21_71.PE2; -.
KW   ENSBTAG00000035998fold_1320000031; ENSBTAP00000047181fold_1320000031;
KW   Q9N1C7_BOVIN; AF207866; BC102333; BT020708;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase.
SQ   SEQUENCE   381 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPFSNSHNTL KLRFPAEDEF PDLSGHNNHM AKVLTPELYA ELRAKSTPSG FTVDDVIQTG
     VDNPGHPYIM TVGCVAGDEE SYDVFKELFD PIIEDRHGGY KPTDEHKTDL NPDNLQGGDD
     LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT
     EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWIN EEDHLRVISM
     QKGGNMKEVF TRFCNGLTQI ETLFKSKNYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP
     HLGKHEKFPE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL
     IEMEQRLEQG QAIDDLMPAQ K
//

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