(data stored in ACNUC941 zone)

HOGENOM: CANFA8_76_PE13

ID   CANFA8_76_PE13                       STANDARD;      PRT;   408 AA.
AC   CANFA8_76_PE13; P05124;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Creatine kinase B-type; EC=2.7.3 2;AltName:
DE   Full=B-CK;AltName: Full=Creatine kinase B chain; (CANFA8_76.PE13).
GN   Name=CKB;
OS   CANIS LUPUS FAMILIARIS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CANFA8_76.PE13.
CC       Canis familiaris chromosome 8 BROADD2 partial sequence 73647349..746473
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRB_CANFA
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Canis_familiaris;ENSCAFG00000018277;ENSCAFT00000029035;ENSCAFP00000026998.
DR   EMBL; M13453; - ;
DR   UniProtKB/Swiss-Prot; P05124; -.
DR   EMBL; M13453; AAA30837.1; -; mRNA.
DR   PIR; A24227; B24686.
DR   ProteinModelPortal; P05124; -.
DR   SMR; P05124; 2-381.
DR   eggNOG; maNOG04306; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; P05124; -.
DR   OrthoDB; EOG4R7V9X; -.
DR   PhylomeDB; P05124; -.
DR   GO; GO:0005739; C:mitochondrion; ISS:AgBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; IEA:EC.
DR   GO; GO:0007420; P:brain development; ISS:AgBase.
DR   GO; GO:0030644; P:cellular chloride ion homeostasis; ISS:AgBase.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; CANFA8_76.PE13; -.
KW   ENSCAFG00000018277fold_1320000031; ENSCAFP00000026998fold_1320000031;
KW   M13453;
KW   ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Transferase.
SQ   SEQUENCE   408 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     APRPELPTDR LPLPRPATRP PSLPAACLPF SNSHNTLKLR FPAEDEFPDL SAHNNHMAKV
     LTPELYAELR AKSTPSGFTL DDVIQTGVDN PGHPYIMTVG CVAGDEESYD VFKELFDPII
     EDRHGGYKPS DEHKTDLNPD NLQGGDDLDP NYVLSSRVRT GRSIRGFCLP PHCSRGERRA
     IEKLAVEALS SLDGDLAGRY YALKSMTEAE QQQLIDDHFL FDKPVSPLLL ASGMARDWPD
     ARGIWHNDNK TFLVWINEED HLRVISMQKG GNMKEVFTRF CNGLTQIETL FKSKNYEFMW
     NPHLGYILTC PSNLGTGLRA GVHIKLPHLG KHEKFPEVLK RLRLQKRGTG GVDTAAVGGV
     FDVSNADRLG FSEVELVQMV VDGVKLLIEM EQRLEQGQAI DDLVPAQK
//

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