(data stored in ACNUC941 zone)

HOGENOM: HS14_PE1524

ID   HS14_PE1524                          STANDARD;      PRT;   381 AA.
AC   HS14_PE1524; P12277; A8K236; B2R5R4; Q2LE07; Q6FG40; Q9UC66;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase B-type; EC=2.7.3 2;AltName:
DE   Full=B-CK;AltName: Full=Creatine kinase B chain; (HS14.PE1524).
GN   Name=CKB; Synonyms=CKBB;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS14.PE1524.
CC       Homo sapiens chromosome 14 GRCh37  sequence 1..107289540 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRB_HUMAN
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/ckb/";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Creatine kinase entry;
CC       URL="http://en.wikipedia.org/wiki/Creatine_kinase";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=CKB entry;
CC       URL="http://en.wikipedia.org/wiki/CKB_(gene)";
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000166165;ENST00000348956;ENSP00000299198.
DR   EMBL; AK290101; - ;
DR   EMBL; AK312282; - ;
DR   EMBL; BC001190; - ;
DR   EMBL; BC004914; - ;
DR   EMBL; BC008323; - ;
DR   EMBL; BC010002; - ;
DR   EMBL; BC019259; - ;
DR   EMBL; BC019281; - ;
DR   EMBL; CH471061; - ;
DR   EMBL; CR542268; - ;
DR   EMBL; DQ333313; - ;
DR   EMBL; L47647; - ;
DR   EMBL; M16364; - ;
DR   EMBL; M16451; - ;
DR   EMBL; M21237; - ;
DR   EMBL; M21238; - ;
DR   EMBL; M21239; - ;
DR   EMBL; M21240; - ;
DR   EMBL; M21241; - ;
DR   EMBL; M21242; - ;
DR   EMBL; M21243; - ;
DR   EMBL; M22355; - ;
DR   EMBL; M22356; - ;
DR   EMBL; X15334; - ;
DR   UniProtKB/Swiss-Prot; P12277; A8K236; B2R5R4; Q2LE07; Q6FG40; Q9UC66; -.
DR   EMBL; M16451; AAA76851.1; -; mRNA.
DR   EMBL; M21243; AAC31758.1; -; Genomic_DNA.
DR   EMBL; M21237; AAC31758.1; JOINED; Genomic_DNA.
DR   EMBL; M21238; AAC31758.1; JOINED; Genomic_DNA.
DR   EMBL; M21239; AAC31758.1; JOINED; Genomic_DNA.
DR   EMBL; M21240; AAC31758.1; JOINED; Genomic_DNA.
DR   EMBL; M21241; AAC31758.1; JOINED; Genomic_DNA.
DR   EMBL; M21242; AAC31758.1; JOINED; Genomic_DNA.
DR   EMBL; L47647; AAA76852.1; -; mRNA.
DR   EMBL; M16364; AAA76850.1; -; mRNA.
DR   EMBL; X15334; CAA33389.1; -; Genomic_DNA.
DR   EMBL; AK290101; BAF82790.1; -; mRNA.
DR   EMBL; AK312282; BAG35211.1; -; mRNA.
DR   EMBL; CR542268; CAG47064.1; -; mRNA.
DR   EMBL; DQ333313; ABC67465.1; -; Genomic_DNA.
DR   EMBL; CH471061; EAW81822.1; -; Genomic_DNA.
DR   EMBL; BC001190; AAH01190.1; -; mRNA.
DR   EMBL; BC004914; AAH04914.1; -; mRNA.
DR   EMBL; BC008323; AAH08323.1; -; mRNA.
DR   EMBL; BC010002; AAH10002.1; -; mRNA.
DR   EMBL; BC019259; AAH19259.1; -; mRNA.
DR   EMBL; BC019281; AAH19281.1; -; mRNA.
DR   EMBL; M22356; AAA52024.1; -; Genomic_DNA.
DR   EMBL; M22355; AAA52024.1; JOINED; Genomic_DNA.
DR   IPI; IPI00022977; -.
DR   PIR; S15935; KIHUCB.
DR   RefSeq; NP_001814.2; NM_001823.3.
DR   UniGene; Hs.173724; -.
DR   PDB; 3B6R; X-ray; 2.00 A; A/B=1-381.
DR   PDB; 3DRB; X-ray; 2.00 A; A/B=1-381.
DR   PDB; 3DRE; X-ray; 2.20 A; A/B=1-381.
DR   PDBsum; 3B6R; -.
DR   PDBsum; 3DRB; -.
DR   PDBsum; 3DRE; -.
DR   ProteinModelPortal; P12277; -.
DR   SMR; P12277; 6-381.
DR   IntAct; P12277; 12.
DR   MINT; MINT-1484821; -.
DR   STRING; P12277; -.
DR   PhosphoSite; P12277; -.
DR   PHCI-2DPAGE; P12277; -.
DR   REPRODUCTION-2DPAGE; IPI00022977; -.
DR   REPRODUCTION-2DPAGE; P12277; -.
DR   UCD-2DPAGE; P12277; -.
DR   PeptideAtlas; P12277; -.
DR   PRIDE; P12277; -.
DR   Ensembl; ENST00000348956; ENSP00000299198; ENSG00000166165.
DR   GeneID; 1152; -.
DR   KEGG; hsa:1152; -.
DR   UCSC; uc001ynf.1; human.
DR   CTD; 1152; -.
DR   GeneCards; GC14M103986; -.
DR   H-InvDB; HIX0012001; -.
DR   HGNC; HGNC:1991; CKB.
DR   HPA; HPA001254; -.
DR   MIM; 123280; gene.
DR   neXtProt; NX_P12277; -.
DR   PharmGKB; PA26528; -.
DR   eggNOG; prNOG07258; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; P12277; -.
DR   OMA; RGHEFMW; -.
DR   OrthoDB; EOG4R7V9X; -.
DR   PhylomeDB; P12277; -.
DR   BioCyc; MetaCyc:MONOMER-14573; -.
DR   Reactome; REACT_13; Metabolism of amino acids and derivatives.
DR   DrugBank; DB00148; Creatine.
DR   NextBio; 4784; -.
DR   ArrayExpress; P12277; -.
DR   Bgee; P12277; -.
DR   CleanEx; HS_CKB; -.
DR   Genevestigator; P12277; -.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; TAS:ProtInc.
DR   GO; GO:0006600; P:creatine metabolic process; EXP:Reactome.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; HS14.PE1524; -.
KW   ENSG000001661651755old_1320000031; ENSP000002991987901old_1320000031;
KW   AK290101; AK312282; BC001190; BC004914; BC008323; BC010002; BC019259;
KW   CH471061; CR542268; DQ333313; L47647; M16364; M16451; M21237; M21238;
KW   M21240; M21241; M21242; M21243; M22355; M22356; X15334;
KW   3D-structure; ATP-binding; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Polymorphism; Reference proteome; Transferase.
SQ   SEQUENCE   381 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG FTLDDVIQTG
     VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD
     LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT
     EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM
     QKGGNMKEVF TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP
     NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL
     IEMEQRLEQG QAIDDLMPAQ K
//

If you have problems or comments...

PBIL Back to PBIL home page