(data stored in ACNUC941 zone)

HOGENOM: HS15_PE488

ID   HS15_PE488                           STANDARD;      PRT;   448 AA.
AC   HS15_PE488; P12532; B4DIT8; B7ZA09; Q0VAM3; Q32NF6; Q53FC4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase U-type, mitochondrial; EC=2.7.3 2;AltName:
DE   Full=Acidic-type mitochondrial creatine kinase; Short=Mia-CK;AltName:
DE   Full=Ubiquitous mitochondrial creatine kinase; Short=U-MtCK;Flags:
DE   Precursor; (HS15.PE488).
GN   Name=CKMT1A; Synonyms=CKMT;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS15.PE488.
CC       Homo sapiens chromosome 15 GRCh37  sequence 1..102521392 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRU_HUMAN
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Exists as an octamer composed of four MTCK homodimers.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral
CC       membrane protein; Intermembrane side.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P12532-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P12532-2; Sequence=VSP_038045;
CC   -!- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000223572;ENST00000424065;ENSP00000392779.
DR   EMBL; AC011330; - ;
DR   EMBL; AK223365; - ;
DR   EMBL; AK293790; - ;
DR   EMBL; AK295776; - ;
DR   EMBL; AK316124; - ;
DR   EMBL; AK316319; - ;
DR   EMBL; BC001926; - ;
DR   EMBL; BC006467; - ;
DR   EMBL; BC108652; - ;
DR   EMBL; BC121001; - ;
DR   EMBL; BC121002; - ;
DR   EMBL; BT006628; - ;
DR   EMBL; J04469; - ;
DR   UniProtKB/Swiss-Prot; P12532; B4DIT8; B7ZA09; Q0VAM3; Q32NF6; Q53FC4; -.
DR   EMBL; J04469; AAA98744.1; -; Genomic_DNA.
DR   EMBL; BT006628; AAP35274.1; -; mRNA.
DR   EMBL; AK295776; BAG58600.1; -; mRNA.
DR   EMBL; AK223365; BAD97085.1; -; mRNA.
DR   EMBL; AK316124; BAH14495.1; -; mRNA.
DR   EMBL; AK316319; BAH14690.1; -; mRNA.
DR   EMBL; BC001926; AAH01926.1; -; mRNA.
DR   EMBL; BC006467; AAH06467.1; -; mRNA.
DR   EMBL; BC108652; AAI08653.1; -; mRNA.
DR   EMBL; BC121001; AAI21002.1; -; mRNA.
DR   EMBL; BC121002; AAI21003.1; -; mRNA.
DR   IPI; IPI00658109; -.
DR   IPI; IPI00877726; -.
DR   PIR; A31431; A30789.
DR   RefSeq; NP_001015001.1; NM_001015001.1.
DR   RefSeq; NP_066270.1; NM_020990.3.
DR   UniGene; Hs.425633; -.
DR   UniGene; Hs.654988; -.
DR   PDB; 1QK1; X-ray; 2.70 A; A/B/C/D/E/F/G/H=39-417.
DR   PDBsum; 1QK1; -.
DR   ProteinModelPortal; P12532; -.
DR   SMR; P12532; 39-417.
DR   MINT; MINT-3304503; -.
DR   STRING; P12532; -.
DR   PhosphoSite; P12532; -.
DR   UCD-2DPAGE; P12532; -.
DR   PeptideAtlas; P12532; -.
DR   PRIDE; P12532; -.
DR   Ensembl; ENST00000300283; ENSP00000300283; ENSG00000237289.
DR   Ensembl; ENST00000381694; ENSP00000371113; ENSG00000223572.
DR   Ensembl; ENST00000413453; ENSP00000406577; ENSG00000223572.
DR   Ensembl; ENST00000413657; ENSP00000390428; ENSG00000237289.
DR   Ensembl; ENST00000424065; ENSP00000392779; ENSG00000223572.
DR   Ensembl; ENST00000434505; ENSP00000413165; ENSG00000223572.
DR   Ensembl; ENST00000441322; ENSP00000413255; ENSG00000237289.
DR   GeneID; 1159; -.
DR   GeneID; 548596; -.
DR   KEGG; hsa:1159; -.
DR   KEGG; hsa:548596; -.
DR   UCSC; uc001zsc.1; human.
DR   CTD; 1159; -.
DR   CTD; 548596; -.
DR   GeneCards; GC15P020720; -.
DR   GeneCards; GC15P020808; -.
DR   H-InvDB; HIX0012187; -.
DR   H-InvDB; HIX0023245; -.
DR   HGNC; HGNC:31736; CKMT1A.
DR   HGNC; HGNC:1995; CKMT1B.
DR   MIM; 123290; gene.
DR   MIM; 613415; gene.
DR   neXtProt; NX_P12532; -.
DR   PharmGKB; PA142672108; -.
DR   eggNOG; prNOG10393; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; P12532; -.
DR   OMA; ERHNGYN; -.
DR   OrthoDB; EOG40VVPN; -.
DR   PhylomeDB; P12532; -.
DR   BioCyc; MetaCyc:MONOMER-14593; -.
DR   Reactome; REACT_13; Metabolism of amino acids and derivatives.
DR   DrugBank; DB00148; Creatine.
DR   NextBio; 4808; -.
DR   ArrayExpress; P12532; -.
DR   Bgee; P12532; -.
DR   CleanEx; HS_CKMT1A; -.
DR   CleanEx; HS_CKMT1B; -.
DR   Genevestigator; P12532; -.
DR   GermOnline; ENSG00000166998; Homo sapiens.
DR   GermOnline; ENSG00000168775; Homo sapiens.
DR   GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; TAS:ProtInc.
DR   GO; GO:0006600; P:creatine metabolic process; EXP:Reactome.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; HS15.PE488; -.
KW   ENSG000002235721755old_1320000031; ENSP000003927797901old_1320000031;
KW   B4DEU2_HUMAN; C9J6W7_HUMAN; C9JFS8_HUMAN; C9JT96_HUMAN; AC011330;
KW   AK293790; AK295776; AK316124; AK316319; BC001926; BC006467; BC108652;
KW   BC121002; BT006628; J04469;
KW   3D-structure; Alternative splicing; ATP-binding; Complete proteome;
KW   Kinase; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase;
KW   Transit peptide.
SQ   SEQUENCE   448 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRPEPVRAA SERRRLYPPS QTWPTGQLPG
     NCTRSRRLCP PSMVTGYPLP SAEYPDLRKH NNCMASHLTP AVYARLCDKT TPTGWTLDQC
     IQTGVDNPGH PFIKTVGMVA GDEETYEVFA DLFDPVIQER HNGYDPRTMK HTTDLDASKI
     RSGYFDERYV LSSRVRTGRS IRGLSLPPAC TRAERREVER VVVDALSGLK GDLAGRYYRL
     SEMTEAEQQQ LIDDHFLFDK PVSPLLTAAG MARDWPDARG IWHNNEKSFL IWVNEEDHTR
     VISMEKGGNM KRVFERFCRG LKEVERLIQE RGWEFMWNER LGYILTCPSN LGTGLRAGVH
     IKLPLLSKDS RFPKILENLR LQKRGTGGVD TAATGGVFDI SNLDRLGKSE VELVQLVIDG
     VNYLIDCERR LERGQDIRIP TPVIHTKH
//

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