(data stored in ACNUC941 zone)

HOGENOM: HS19_PE2366

ID   HS19_PE2366                          STANDARD;      PRT;   381 AA.
AC   HS19_PE2366; P06732; Q96QL9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase M-type; EC=2.7.3 2;AltName: Full=Creatine
DE   kinase M chain;AltName: Full=M-CK; (HS19.PE2366).
GN   Name=CKM; Synonyms=CKMM;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS19.PE2366.
CC       Homo sapiens chromosome 19 GRCh37  sequence 1..59118983 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRM_HUMAN
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Creatine kinase entry;
CC       URL="http://en.wikipedia.org/wiki/Creatine_kinase";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/ckm/";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=CKM entry;
CC       URL="http://en.wikipedia.org/wiki/CKM_(gene)";
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000104879;ENST00000221476;ENSP00000221476.
DR   EMBL; AC005781; - ;
DR   EMBL; AK313281; - ;
DR   EMBL; AY585238; - ;
DR   EMBL; BC007462; - ;
DR   EMBL; BT006793; - ;
DR   EMBL; M14780; - ;
DR   EMBL; M16440; - ;
DR   EMBL; M21488; - ;
DR   EMBL; M21489; - ;
DR   EMBL; M21490; - ;
DR   EMBL; M21491; - ;
DR   EMBL; M21492; - ;
DR   EMBL; M21493; - ;
DR   EMBL; M21494; - ;
DR   UniProtKB/Swiss-Prot; P06732; Q96QL9; -.
DR   EMBL; M14780; AAA52025.1; -; mRNA.
DR   EMBL; M21494; AAA96609.1; -; Genomic_DNA.
DR   EMBL; M21488; AAA96609.1; JOINED; Genomic_DNA.
DR   EMBL; M21489; AAA96609.1; JOINED; Genomic_DNA.
DR   EMBL; M21490; AAA96609.1; JOINED; Genomic_DNA.
DR   EMBL; M21491; AAA96609.1; JOINED; Genomic_DNA.
DR   EMBL; M21492; AAA96609.1; JOINED; Genomic_DNA.
DR   EMBL; M21493; AAA96609.1; JOINED; Genomic_DNA.
DR   EMBL; BT006793; AAP35439.1; -; mRNA.
DR   EMBL; AY585238; AAS79321.1; -; Genomic_DNA.
DR   EMBL; AC005781; AAC62841.1; -; Genomic_DNA.
DR   EMBL; BC007462; AAH07462.1; -; mRNA.
DR   EMBL; M16440; AAA52026.1; ALT_SEQ; mRNA.
DR   IPI; IPI00027487; -.
DR   PIR; A31793; KIHUCM.
DR   RefSeq; NP_001815.2; NM_001824.3.
DR   UniGene; Hs.334347; -.
DR   PDB; 1I0E; X-ray; 3.50 A; A/B/C/D=1-381.
DR   PDBsum; 1I0E; -.
DR   ProteinModelPortal; P06732; -.
DR   SMR; P06732; 8-381.
DR   STRING; P06732; -.
DR   PhosphoSite; P06732; -.
DR   UCD-2DPAGE; P06732; -.
DR   PeptideAtlas; P06732; -.
DR   PRIDE; P06732; -.
DR   Ensembl; ENST00000221476; ENSP00000221476; ENSG00000104879.
DR   GeneID; 1158; -.
DR   KEGG; hsa:1158; -.
DR   UCSC; uc002pbd.1; human.
DR   CTD; 1158; -.
DR   GeneCards; GC19M042241; -.
DR   H-InvDB; HIX0015228; -.
DR   HGNC; HGNC:1994; CKM.
DR   MIM; 123310; gene.
DR   neXtProt; NX_P06732; -.
DR   PharmGKB; PA26532; -.
DR   eggNOG; prNOG05338; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; P06732; -.
DR   OMA; IRASVMM; -.
DR   OrthoDB; EOG4R7V9X; -.
DR   PhylomeDB; P06732; -.
DR   BioCyc; MetaCyc:MONOMER-14572; -.
DR   Reactome; REACT_13; Metabolism of amino acids and derivatives.
DR   DrugBank; DB00148; Creatine.
DR   NextBio; 4804; -.
DR   ArrayExpress; P06732; -.
DR   Bgee; P06732; -.
DR   CleanEx; HS_CKM; -.
DR   Genevestigator; P06732; -.
DR   GermOnline; ENSG00000104879; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; TAS:ProtInc.
DR   GO; GO:0006600; P:creatine metabolic process; EXP:Reactome.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; HS19.PE2366; -.
KW   ENSG000001048791755old_1320000031; ENSP000002214767901old_1320000031;
KW   B2R892_HUMAN; AC005781; AK313281; AY585238; BC007462; BT006793; M14780;
KW   M21488; M21489; M21490; M21491; M21492; M21493; M21494;
KW   3D-structure; ATP-binding; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Kinase; Nucleotide-binding; Polymorphism;
KW   Reference proteome; Transferase.
SQ   SEQUENCE   381 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPFGNTHNKF KLNYKPEEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG FTVDDVIQTG
     VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY KPTDKHKTDL NHENLKGGDD
     LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT
     EKEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM
     EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA
     HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV QLVVDGVKLM
     VEMEKKLEKG QSIDDMIPAQ K
//

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