(data stored in ACNUC941 zone)

HOGENOM: HS5_PE1441

ID   HS5_PE1441                           STANDARD;      PRT;   419 AA.
AC   HS5_PE1441; P17540; Q6ICS8; Q8N1E1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase S-type, mitochondrial; EC=2.7.3 2;AltName:
DE   Full=Basic-type mitochondrial creatine kinase; Short=Mib-CK;AltName:
DE   Full=Sarcomeric mitochondrial creatine kinase; Short=S-MtCK;Flags:
DE   Precursor; (HS5.PE1441).
GN   Name=CKMT2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS5.PE1441.
CC       Homo sapiens chromosome 5 GRCh37  sequence 1..180905260 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRS_HUMAN
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Exists as an octamer composed of four CKMT2 homodimers.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral
CC       membrane protein; Intermembrane side.
CC   -!- TISSUE SPECIFICITY: Sarcomere-specific. Found only in heart and
CC       skeletal muscles.
CC   -!- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000131730;ENST00000254035;ENSP00000254035.
DR   EMBL; AC020901; - ;
DR   EMBL; AC026436; - ;
DR   EMBL; AK122769; - ;
DR   EMBL; AK313293; - ;
DR   EMBL; BC029140; - ;
DR   EMBL; CR450315; - ;
DR   EMBL; J05401; - ;
DR   UniProtKB/Swiss-Prot; P17540; Q6ICS8; Q8N1E1; -.
DR   EMBL; J05401; AAA60561.1; -; mRNA.
DR   EMBL; CR450315; CAG29311.1; -; mRNA.
DR   EMBL; BC029140; AAH29140.1; -; mRNA.
DR   IPI; IPI00015141; -.
DR   PIR; A35756; A35756.
DR   RefSeq; NP_001093205.1; NM_001099735.1.
DR   RefSeq; NP_001093206.1; NM_001099736.1.
DR   RefSeq; NP_001816.2; NM_001825.2.
DR   UniGene; Hs.80691; -.
DR   PDB; 2GL6; X-ray; 2.30 A; A/B/C/D/E/F/G/H=27-416.
DR   PDBsum; 2GL6; -.
DR   ProteinModelPortal; P17540; -.
DR   SMR; P17540; 47-413.
DR   IntAct; P17540; 3.
DR   MINT; MINT-5004086; -.
DR   STRING; P17540; -.
DR   PhosphoSite; P17540; -.
DR   UCD-2DPAGE; P17540; -.
DR   PRIDE; P17540; -.
DR   Ensembl; ENST00000254035; ENSP00000254035; ENSG00000131730.
DR   Ensembl; ENST00000424301; ENSP00000404203; ENSG00000131730.
DR   Ensembl; ENST00000437669; ENSP00000410289; ENSG00000131730.
DR   GeneID; 1160; -.
DR   KEGG; hsa:1160; -.
DR   UCSC; uc003khc.2; human.
DR   CTD; 1160; -.
DR   GeneCards; GC05P075738; -.
DR   H-InvDB; HIX0200769; -.
DR   HGNC; HGNC:1996; CKMT2.
DR   MIM; 123295; gene.
DR   neXtProt; NX_P17540; -.
DR   PharmGKB; PA26534; -.
DR   eggNOG; prNOG18637; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; P17540; -.
DR   OMA; LPQFGRK; -.
DR   OrthoDB; EOG40VVPN; -.
DR   PhylomeDB; P17540; -.
DR   BioCyc; MetaCyc:MONOMER-14594; -.
DR   Reactome; REACT_13; Metabolism of amino acids and derivatives.
DR   DrugBank; DB00148; Creatine.
DR   NextBio; 4814; -.
DR   ArrayExpress; P17540; -.
DR   Bgee; P17540; -.
DR   CleanEx; HS_CKMT2; -.
DR   Genevestigator; P17540; -.
DR   GermOnline; ENSG00000131730; Homo sapiens.
DR   GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; TAS:ProtInc.
DR   GO; GO:0006600; P:creatine metabolic process; EXP:Reactome.
DR   GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; HS5.PE1441; -.
KW   ENSG000001317301755old_1320000031; ENSP000002540357901old_1320000031;
KW   B2R8A3_HUMAN; B3KVA7_HUMAN; D6R998_HUMAN; AC020901; AC026436; AK122769;
KW   BC029140; CR450315; J05401;
KW   3D-structure; ATP-binding; Complete proteome;
KW   Direct protein sequencing; Kinase; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Nucleotide-binding; Reference proteome;
KW   Transferase; Transit peptide.
SQ   SEQUENCE   419 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASIFSKLLT GRNASLLFAT MGTSVLTTGY LLNRQKVCAE VREQPRLFPP SADYPDLRKH
     NNCMAECLTP AIYAKLRNKV TPNGYTLDQC IQTGVDNPGH PFIKTVGMVA GDEESYEVFA
     DLFDPVIKLR HNGYDPRVMK HTTDLDASKI TQGQFDEHYV LSSRVRTGRS IRGLSLPPAC
     TRAERREVEN VAITALEGLK GDLAGRYYKL SEMTEQDQQR LIDDHFLFDK PVSPLLTCAG
     MARDWPDARG IWHNYDKTFL IWINEEDHTR VISMEKGGNM KRVFERFCRG LKEVERLIQE
     RGWEFMWNER LGYILTCPSN LGTGLRAGVH VRIPKLSKDP RFSKILENLR LQKRGTGGVD
     TAAVADVYDI SNIDRIGRSE VELVQIVIDG VNYLVDCEKK LERGQDIKVP PPLPQFGKK
//

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