(data stored in ACNUC941 zone)

HOGENOM: MOUSE13_PE1286

ID   MOUSE13_PE1286                       STANDARD;      PRT;   419 AA.
AC   MOUSE13_PE1286; Q6P8J7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase S-type, mitochondrial; EC=2.7.3 2;AltName:
DE   Full=Basic-type mitochondrial creatine kinase; Short=Mib-CK;AltName:
DE   Full=Sarcomeric mitochondrial creatine kinase; Short=S-MtCK;Flags:
DE   Precursor; (MOUSE13.PE1286).
GN   Name=Ckmt2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE13.PE1286.
CC       Mus musculus chromosome 13 NCBIM37  sequence 1..120284312 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRS_MOUSE
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Exists as an octamer composed of four CKMT2 homodimers
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral
CC       membrane protein; Intermembrane side (By similarity).
CC   -!- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000021622;ENSMUST00000022122;ENSMUSP00000022122.
DR   EMBL; BC061221; - ;
DR   UniProtKB/Swiss-Prot; Q6P8J7; -.
DR   EMBL; BC061221; AAH61221.1; -; mRNA.
DR   IPI; IPI00120076; -.
DR   RefSeq; NP_940807.1; NM_198415.2.
DR   UniGene; Mm.316438; -.
DR   ProteinModelPortal; Q6P8J7; -.
DR   SMR; Q6P8J7; 47-413.
DR   STRING; Q6P8J7; -.
DR   PhosphoSite; Q6P8J7; -.
DR   PRIDE; Q6P8J7; -.
DR   Ensembl; ENSMUST00000022122; ENSMUSP00000022122; ENSMUSG00000021622.
DR   GeneID; 76722; -.
DR   KEGG; mmu:76722; -.
DR   UCSC; uc007rkc.1; mouse.
DR   CTD; 1160; -.
DR   MGI; MGI:1923972; Ckmt2.
DR   eggNOG; roNOG05439; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; Q6P8J7; -.
DR   OMA; LPQFGRK; -.
DR   OrthoDB; EOG40VVPN; -.
DR   PhylomeDB; Q6P8J7; -.
DR   NextBio; 345699; -.
DR   ArrayExpress; Q6P8J7; -.
DR   Bgee; Q6P8J7; -.
DR   CleanEx; MM_CKMT2; -.
DR   Genevestigator; Q6P8J7; -.
DR   GermOnline; ENSMUSG00000021622; Mus musculus.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; TAS:MGI.
DR   GO; GO:0006603; P:phosphocreatine metabolic process; TAS:MGI.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; MOUSE13.PE1286; -.
KW   ENSMUSG000000216225old_1320000031; ENSMUSP000000221221old_1320000031;
KW   BC061221;
KW   ATP-binding; Complete proteome; Direct protein sequencing; Kinase;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Nucleotide-binding; Reference proteome; Transferase; Transit peptide.
SQ   SEQUENCE   419 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASAFSKLLT GRNASLLFTT LGTSALTTGY LLNRQKVSAD AREQHKLFPP SADYPDLRKH
     NNCMAECLTP TIYAKLRNKM TPSGYTLDQC IQTGVDNPGH PFIKTVGMVA GDEESYEVFA
     DLFDPVIKLR HNGYDPRVMK HPTDLDASKI THGQFDERYV LSSRVRTGRS IRGLSLPPAC
     SRAERREVEN VAITALEGLK GDLAGRYYKL SEMTEQDQQR LIDDHFLFDK PVSPLLTCAG
     MARDWPDARG IWHNYDKTFL IWINEEDHTR VISMEKGGNM KRVFERFCRG LKEVERLIQE
     RGWEFMWNER LGYILTCPSN LGTGLRAGVH VRIPKLSKDP RFSKILENLR LQKRGTGGVD
     TAAVADVYDI SNIDRIGRSE VELVQIVIDG VNYLVDCEKK LERGQDIKVP PPLPQFGRK
//

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