(data stored in ACNUC941 zone)

HOGENOM: MOUSE2_PE3087

ID   MOUSE2_PE3087                        STANDARD;      PRT;   418 AA.
AC   MOUSE2_PE3087; P30275;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase U-type, mitochondrial; EC=2.7.3 2;AltName:
DE   Full=Acidic-type mitochondrial creatine kinase; Short=Mia-CK;AltName:
DE   Full=Ubiquitous mitochondrial creatine kinase; Short=U-MtCK;Flags:
DE   Precursor; (MOUSE2.PE3087).
GN   Name=Ckmt1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE2.PE3087.
CC       Mus musculus chromosome 2 NCBIM37  sequence 1..181748087 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRU_MOUSE
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Exists as an octamer composed of four MTCK homodimers.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral
CC       membrane protein; Intermembrane side.
CC   -!- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000000308;ENSMUST00000078222;ENSMUSP00000077349.
DR   EMBL; AK005076; - ;
DR   EMBL; AK131953; - ;
DR   EMBL; AL845466; - ;
DR   EMBL; BC025976; - ;
DR   EMBL; CH466519; - ;
DR   EMBL; Z13968; - ;
DR   EMBL; Z13969; - ;
DR   UniProtKB/Swiss-Prot; P30275; -.
DR   EMBL; Z13968; CAA78371.1; -; mRNA.
DR   EMBL; Z13969; CAA78372.1; -; Genomic_DNA.
DR   EMBL; BC025976; AAH25976.1; -; mRNA.
DR   IPI; IPI00128296; -.
DR   PIR; I48308; S24612.
DR   RefSeq; NP_034027.1; NM_009897.2.
DR   UniGene; Mm.252145; -.
DR   ProteinModelPortal; P30275; -.
DR   SMR; P30275; 40-418.
DR   IntAct; P30275; 3.
DR   STRING; P30275; -.
DR   PhosphoSite; P30275; -.
DR   PRIDE; P30275; -.
DR   Ensembl; ENSMUST00000000317; ENSMUSP00000000317; ENSMUSG00000000308.
DR   Ensembl; ENSMUST00000078222; ENSMUSP00000077349; ENSMUSG00000000308.
DR   GeneID; 12716; -.
DR   KEGG; mmu:12716; -.
DR   CTD; 12716; -.
DR   MGI; MGI:99441; Ckmt1.
DR   InParanoid; P30275; -.
DR   OMA; ERHNGYN; -.
DR   OrthoDB; EOG40VVPN; -.
DR   PhylomeDB; P30275; -.
DR   NextBio; 281988; -.
DR   ArrayExpress; P30275; -.
DR   Bgee; P30275; -.
DR   CleanEx; MM_CKMT1; -.
DR   Genevestigator; P30275; -.
DR   GermOnline; ENSMUSG00000000308; Mus musculus.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; IEA:EC.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; MOUSE2.PE3087; -.
KW   ENSMUSG000000003085old_1320000031; ENSMUSP000000773491old_1320000031;
KW   A2ARP5_MOUSE; B0R0E8_MOUSE; B0R0E9_MOUSE; Q545N7_MOUSE; AK005076;
KW   AL845466; BC025976; CH466519; Z13968; Z13969;
KW   ATP-binding; Complete proteome; Direct protein sequencing; Kinase;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Nitration;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase;
KW   Transit peptide.
SQ   SEQUENCE   418 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGPFSRLLS ARPGLRLLAL AGAGSLTAGI LLRPESVGAA AAERRRLYPP SAEYPDLRKH
     NNCMASHLTP AVYARLCDKT TPTGWTLDQC IQTGVDNPGH PFIKTVGMVA GDEETYEVFA
     ELFDPVIQER HNGYDPRTMK HTTDLDASKI RSGYFDERYV LSSRVRTGRS IRGLSLPPAC
     TRAERREVER VVVDALSGLK GDLAGRYYRL SEMTEAEQQQ LIDDHFLFDK PVSPLLTAAG
     MARDWPDARG IWHNNEKSFL IWVNEEDHTR VISMEKGGNM KRVFERFCRG LKEVEKLIQE
     RGWEFMWNER LGYILTCPSN LGTGLRAGVH IKLPLLSKDN RFPKILENLR LQKRGTGGVD
     TAATGSVFDI SNLDRLGKSE VELVQLVIDG VNYLIDCERR LERGQDIRIP PPLVHSKH
//

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