(data stored in ACNUC941 zone)

HOGENOM: RABITUN0053_1_PE12

ID   RABITUN0053_1_PE12                   STANDARD;      PRT;   388 AA.
AC   RABITUN0053_1_PE12; P00567;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase B-type; EC=2.7.3 2;AltName:
DE   Full=B-CK;AltName: Full=Creatine kinase B chain; (RABITUN0053_1.PE12).
GN   Name=CKB;
OS   ORYCTOLAGUS CUNICULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RABITUN0053_1.PE12.
CC       Oryctolagus cuniculus chromosome Un0053 oryCun2 partial sequence 1..100
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRB_RABIT
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Oryctolagus_cuniculus;ENSOCUG00000008818;ENSOCUT00000008819;ENSOCUP00000007616.
DR   EMBL; M11306; - ;
DR   UniProtKB/Swiss-Prot; P00567; -.
DR   EMBL; M11306; AAA31201.1; -; mRNA.
DR   PIR; A00678; KIRBCB.
DR   RefSeq; NP_001075730.1; NM_001082261.1.
DR   UniGene; Ocu.3366; -.
DR   ProteinModelPortal; P00567; -.
DR   SMR; P00567; 2-381.
DR   Ensembl; ENSOCUT00000008819; ENSOCUP00000007616; ENSOCUG00000008818.
DR   GeneID; 100009085; -.
DR   CTD; 1152; -.
DR   eggNOG; maNOG04306; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   OrthoDB; EOG4R7V9X; -.
DR   GO; GO:0005739; C:mitochondrion; ISS:AgBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; IEA:EC.
DR   GO; GO:0007420; P:brain development; ISS:AgBase.
DR   GO; GO:0030644; P:cellular chloride ion homeostasis; ISS:AgBase.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; RABITUN0053_1.PE12; -.
KW   ENSOCUG00000008818820036002503210000011;
KW   KCRB_RABIT; M11306;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Transferase.
SQ   SEQUENCE   388 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPFSNTHNTL KLRFPAEDEF PDLSAHNNHM AKVLTPEMYA ELRAKSTPSG FTLDDVIQTG
     VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIIEDRHGGY KPSDEHKTDL NPDNALTPGP
     RTQGGDDLDP NYVLSSRVRT GRSIRGFCLP PHCSRGERRA VEKLAVEALS SLDGDLAGRY
     YALKSMTEAE QQQLIDDHFL FDKPVSPLLL ASGMARDWPD ARGIWHNDNK TFLVWINEED
     HLRVISMQKG GNMKEVFTRF CNGLTQIETL FKSKNYEFMW NPHLGYILTC PSNLGTGLRA
     GVHIKLPHLG QHEKFSEVLK RLRLQKRGTG GVDTAAVGGV FDVSNADRLG FSEVELVQMV
     VDGVKLLIEM EQRLEQGQAI DDLMPAQK
//

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