(data stored in ACNUC941 zone)

HOGENOM: RAT1_PE988

ID   RAT1_PE988                           STANDARD;      PRT;   381 AA.
AC   RAT1_PE988; P00564; Q6P6R9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase M-type; EC=2.7.3 2;AltName: Full=Creatine
DE   kinase M chain;AltName: Full=M-CK; (RAT1.PE988).
GN   Name=Ckm; Synonyms=Ckmm;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE988.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRM_RAT
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000016837;ENSRNOT00000022895;ENSRNOP00000022895.
DR   EMBL; BC062058; - ;
DR   EMBL; M10140; - ;
DR   EMBL; M14864; - ;
DR   UniProtKB/Swiss-Prot; P00564; Q6P6R9; -.
DR   EMBL; M10140; AAA40935.1; -; mRNA.
DR   EMBL; BC062058; AAH62058.1; -; mRNA.
DR   EMBL; M14864; AAA40936.1; -; mRNA.
DR   IPI; IPI00211053; -.
DR   PIR; A00674; KIRTCM.
DR   RefSeq; NP_036662.1; NM_012530.1.
DR   UniGene; Rn.10756; -.
DR   ProteinModelPortal; P00564; -.
DR   SMR; P00564; 2-381.
DR   STRING; P00564; -.
DR   PhosphoSite; P00564; -.
DR   Rat-heart-2DPAGE; P00564; -.
DR   PRIDE; P00564; -.
DR   GeneID; 24265; -.
DR   KEGG; rno:24265; -.
DR   UCSC; NM_012530; rat.
DR   CTD; 1158; -.
DR   RGD; 2358; Ckm.
DR   eggNOG; roNOG15359; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; P00564; -.
DR   OrthoDB; EOG4R7V9X; -.
DR   NextBio; 602819; -.
DR   ArrayExpress; P00564; -.
DR   Genevestigator; P00564; -.
DR   GermOnline; ENSRNOG00000016837; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; IDA:RGD.
DR   GO; GO:0046314; P:phosphocreatine biosynthetic process; IDA:RGD.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; RAT1.PE988; -.
KW   ENSRNOG00000016837820036002503210000011;
KW   Ckm; KCRM_RAT; BC062058; M10140; M14864;
KW   ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Kinase; Nucleotide-binding; Reference proteome; Transferase.
SQ   SEQUENCE   381 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPFGNTHNKF KLNYKSQEEY PDLSKHNNHM AKVLTPDLYN KLRDKETPSG FTLDDVIQTG
     VDNPGHPFIM TVGCVAGDEE SYTVFKDLFD PIIQDRHGGF KPTDKHKTDL NHENLKGGDD
     LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT
     EQEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM
     EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNEHLGYV LTCPSNLGTG LRGGVHVKLA
     NLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GAVFDISNAD RLGSSEVEQV QLVVDGVKLM
     VEMEKKLEKG QSIDDMIPAQ K
//

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