(data stored in ACNUC941 zone)

HOGENOM: RAT3_PE1666

ID   RAT3_PE1666                          STANDARD;      PRT;   418 AA.
AC   RAT3_PE1666; P25809;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase U-type, mitochondrial; EC=2.7.3 2;AltName:
DE   Full=Acidic-type mitochondrial creatine kinase; Short=Mia-CK;AltName:
DE   Full=Ubiquitous mitochondrial creatine kinase; Short=U-MtCK;Flags:
DE   Precursor; (RAT3.PE1666).
GN   Name=Ckmt1; Synonyms=Ckmt;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT3.PE1666.
CC       Rattus norvegicus chromosome 3 RGSC3.4  sequence 1..171063335 annotated
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRU_RAT
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Exists as an octamer composed of four MTCK homodimers.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral
CC       membrane protein; Intermembrane side.
CC   -!- TISSUE SPECIFICITY: In many tissues, with highest levels in brain
CC       gut and kidney. In the kidney localized primarily in the outer
CC       medulla in the thick ascending limb and distal convoluted tubule.
CC   -!- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000014573;ENSRNOT00000051354;ENSRNOP00000044253.
DR   EMBL; BC091335; - ;
DR   EMBL; X59737; - ;
DR   UniProtKB/Swiss-Prot; P25809; -.
DR   EMBL; X59737; CAA42415.1; -; mRNA.
DR   IPI; IPI00193445; -.
DR   PIR; S17189; S17189.
DR   UniGene; Rn.155589; -.
DR   ProteinModelPortal; P25809; -.
DR   SMR; P25809; 40-418.
DR   STRING; P25809; -.
DR   PhosphoSite; P25809; -.
DR   World-2DPAGE; 0004:P25809; -.
DR   PRIDE; P25809; -.
DR   UCSC; NM_001012738; rat.
DR   RGD; 61976; Ckmt1.
DR   eggNOG; maNOG10765; -.
DR   InParanoid; P25809; -.
DR   OrthoDB; EOG40VVPN; -.
DR   ArrayExpress; P25809; -.
DR   Genevestigator; P25809; -.
DR   GermOnline; ENSRNOG00000014573; Rattus norvegicus.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; TAS:RGD.
DR   GO; GO:0046314; P:phosphocreatine biosynthetic process; TAS:RGD.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; RAT3.PE1666; -.
KW   ENSRNOG00000014573820036002503210000011;
KW   Ckmt1; KCRU_RAT; Q5BJT9_RAT; BC091335; X59737;
KW   ATP-binding; Complete proteome; Direct protein sequencing; Kinase;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase;
KW   Transit peptide.
SQ   SEQUENCE   418 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGPFSRLLS ARPGLKLLAL AGAGSLAAGI LLRPESVRAA TGERRRLYPP SAEYPDLRKH
     NNCMASHLTP AVYARLCDKT TPTGWTLDQC IQTGVDNPGH PFIKTVGMVA GDEETYEVFA
     ELFDPVIQER HNGYDPRTMK HTTDLDASKI RSGYFDERYV LSSRVRTGRS IRGLSLPPAC
     TRAERREVER VVVDALSGLK GDLAGRYYRL SEMTEAEQQQ LIDDHFLFDK PVSPLLTAAG
     MARDWPDARG IWHNNEKSFL IWVNEEDHTR VISMEKGGNM KRVFERFCRG LKEVEKLIQE
     RGWEFMWNER LGYILTCPSN LGTGLRAGVH VKLPLLSKDS RFPKILENLR LQKRGTGGVD
     TAATGSVFDI SNLDRLGKSE VELVQLVIDG VNYLIDCERR LEKGQDIRIP PPLVHGKH
//

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