(data stored in ACNUC941 zone)

HOGENOM: RAT6_PE1172

ID   RAT6_PE1172                          STANDARD;      PRT;   381 AA.
AC   RAT6_PE1172; P07335; A0JPK7; Q499P7; Q5PPJ5; Q6IRE0; Q6P139;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Creatine kinase B-type; EC=2.7.3 2;AltName:
DE   Full=B-CK;AltName: Full=Creatine kinase B chain; (RAT6.PE1172).
GN   Name=Ckb; Synonyms=Ckbb;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT6.PE1172.
CC       Rattus norvegicus chromosome 6 RGSC3.4  sequence 1..147636619 annotated
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCRB_RAT
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: In the kidney localized primarily in the outer
CC       medulla in the thick ascending limb and distal convoluted tubule.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 phosphagen kinase N-terminal domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH87656.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000232165 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000010872;ENSRNOT00000015122;ENSRNOP00000015122.
DR   EMBL; BC065307; - ;
DR   EMBL; BC070955; - ;
DR   EMBL; BC087656; - ;
DR   EMBL; BC099814; - ;
DR   EMBL; BC127477; - ;
DR   EMBL; M14400; - ;
DR   EMBL; M18668; - ;
DR   EMBL; M57664; - ;
DR   EMBL; M57665; - ;
DR   UniProtKB/Swiss-Prot; P07335; A0JPK7; Q499P7; Q5PPJ5; Q6IRE0; Q6P139; -.
DR   EMBL; M14400; AAA40930.1; -; mRNA.
DR   EMBL; M18668; AAA40932.1; -; Genomic_DNA.
DR   EMBL; M57664; AAA40933.1; -; mRNA.
DR   EMBL; M57665; AAA40931.1; -; Genomic_DNA.
DR   EMBL; BC065307; AAH65307.2; -; mRNA.
DR   EMBL; BC070955; AAH70955.2; -; mRNA.
DR   EMBL; BC087656; AAH87656.1; ALT_INIT; mRNA.
DR   EMBL; BC099814; AAH99814.2; -; mRNA.
DR   EMBL; BC127477; AAI27478.2; -; mRNA.
DR   IPI; IPI00470288; -.
DR   PIR; A23980; KIRTCB.
DR   RefSeq; NP_036661.2; NM_012529.2.
DR   UniGene; Rn.1472; -.
DR   ProteinModelPortal; P07335; -.
DR   SMR; P07335; 2-381.
DR   STRING; P07335; -.
DR   PhosphoSite; P07335; -.
DR   World-2DPAGE; 0004:P07335; -.
DR   PRIDE; P07335; -.
DR   Ensembl; ENSRNOT00000015122; ENSRNOP00000015122; ENSRNOG00000010872.
DR   GeneID; 24264; -.
DR   KEGG; rno:24264; -.
DR   UCSC; NM_012529; rat.
DR   CTD; 1152; -.
DR   RGD; 2357; Ckb.
DR   eggNOG; roNOG15359; -.
DR   GeneTree; ENSGT00550000074561; -.
DR   InParanoid; P07335; -.
DR   OrthoDB; EOG4R7V9X; -.
DR   NextBio; 602815; -.
DR   ArrayExpress; P07335; -.
DR   Genevestigator; P07335; -.
DR   GermOnline; ENSRNOG00000010872; Rattus norvegicus.
DR   GO; GO:0005886; C:plasma membrane; TAS:RGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004111; F:creatine kinase activity; TAS:RGD.
DR   GO; GO:0005515; F:protein binding; IPI:RGD.
DR   GO; GO:0007420; P:brain development; IEP:RGD.
DR   GO; GO:0030644; P:cellular chloride ion homeostasis; IMP:RGD.
DR   GO; GO:0006603; P:phosphocreatine metabolic process; TAS:RGD.
DR   InterPro; IPR000749; ATP-guanido_PTrfase.
DR   InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR   InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR   InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   SUPFAM; SSF48034; ATP-gua_Ptrans; 1.
DR   PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR   PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR   PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
DR   HOGENOMDNA; RAT6.PE1172; -.
KW   ENSRNOG00000010872820036002503210000011;
KW   Ckb; KCRB_RAT; BC065307; BC070955; BC087656; BC099814; BC127477; M14400;
KW   M57664; M57665;
KW   ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Transferase.
SQ   SEQUENCE   381 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPFSNSHNTQ KLRFPAEDEF PDLSSHNNHM AKVLTPELYA ELRAKCTPSG FTLDDAIQTG
     VDNPGHPYIM TVGAVAGDEE SYDVFKDLFD PIIEDRHGGY QPSDEHKTDL NPDNLQGGDD
     LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLS GRYYALKSMT
     EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWIN EEDHLRVISM
     QKGGNMKEVF TRFCTGLTQI ETLFKSKNYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP
     HLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL
     IEMEQRLEQG QPIDDLMPAQ K
//

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