GMMAT: Generalized Linear Mixed Model Association Tests

Perform association tests using generalized linear mixed models (GLMMs) in genome-wide association studies (GWAS) and sequencing association studies. First, GMMAT fits a GLMM with covariate adjustment and random effects to account for population structure and familial or cryptic relatedness. For GWAS, GMMAT performs score tests for each genetic variant as proposed in Chen et al. (2016) <doi:10.1016/j.ajhg.2016.02.012>. For candidate gene studies, GMMAT can also perform Wald tests to get the effect size estimate for each genetic variant. For rare variant analysis from sequencing association studies, GMMAT performs the variant Set Mixed Model Association Tests (SMMAT) as proposed in Chen et al. (2019) <doi:10.1016/j.ajhg.2018.12.012>, including the burden test, the sequence kernel association test (SKAT), SKAT-O and an efficient hybrid test of the burden test and SKAT, based on user-defined variant sets.

Version: 1.0.4
Depends: R (≥ 3.2.0)
Imports: Rcpp, SeqArray, SeqVarTools, CompQuadForm, foreach, parallel
LinkingTo: Rcpp, RcppArmadillo
Suggests: doMC, testthat
Published: 2019-03-06
Author: Han Chen, Matthew P. Conomos
Maintainer: Han Chen <Han.Chen.2 at uth.tmc.edu>
License: GPL-3
Copyright: See COPYRIGHTS for details.
GMMAT copyright details
NeedsCompilation: yes
CRAN checks: GMMAT results

Downloads:

Reference manual: GMMAT.pdf
Vignettes: GMMAT
Package source: GMMAT_1.0.4.tar.gz
Windows binaries: r-devel: GMMAT_1.0.4.zip, r-release: GMMAT_1.0.4.zip, r-oldrel: GMMAT_1.0.4.zip
OS X binaries: r-release: not available, r-oldrel: not available
Old sources: GMMAT archive

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