bfboinet: Backfill Bayesian Optimal Interval Design Using Efficacy and
Toxicity
Implements the Backfill Bayesian Optimal Interval Design (BF-BOIN-ET),
a novel clinical trial methodology for dose optimization that simultaneously consider both efficacy
and toxicity outcome as described in (Takeda et al (2025) <doi:10.1002/pst.2470>).
The package has been extended to include a seamless two-stage phase I/II trial design with backfill
and joint efficacy and toxicity monitoring as described in (Takeda et al (2026) <doi:10.1002/pst.70092>).
| Version: |
1.0.0 |
| Imports: |
Iso, copula, dplyr, tidyselect, magrittr, BOP2FE, boinet, BOIN |
| Published: |
2026-04-14 |
| DOI: |
10.32614/CRAN.package.bfboinet |
| Author: |
Jing Zhu [cre, aut],
Kentaro Takeda [aut],
Yimer Belay Birlie [aut] |
| Maintainer: |
Jing Zhu <zhujing716 at gmail.com> |
| License: |
GPL-3 |
| NeedsCompilation: |
no |
| Materials: |
README, NEWS |
| CRAN checks: |
bfboinet results |
Documentation:
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