MafSequence.h

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//
// File: MafSequence.h
// Authors: Julien Dutheil
// Created: Tue Sep 07 2010
//
 
/*
Copyright or © or Copr. Bio++ Development Team, (2010)
 
This software is a computer program whose purpose is to provide classes
for sequences analysis.
 
This software is governed by the CeCILL  license under French law and
abiding by the rules of distribution of free software.  You can  use, 
modify and/ or redistribute the software under the terms of the CeCILL
license as circulated by CEA, CNRS and INRIA at the following URL
"http://www.cecill.info". 
 
As a counterpart to the access to the source code and  rights to copy,
modify and redistribute granted by the license, users are provided only
with a limited warranty  and the software's author,  the holder of the
economic rights,  and the successive licensors  have only  limited
liability. 
 
In this respect, the user's attention is drawn to the risks associated
with loading,  using,  modifying and/or developing or reproducing the
software by the user in light of its specific status of free software,
that may mean  that it is complicated to manipulate,  and  that  also
therefore means  that it is reserved for developers  and  experienced
professionals having in-depth computer knowledge. Users are therefore
encouraged to load and test the software's suitability as regards their
requirements in conditions enabling the security of their systems and/or 
data to be ensured and,  more generally, to use and operate it in the 
same conditions as regards security. 
 
The fact that you are presently reading this means that you have had
knowledge of the CeCILL license and that you accept its terms.
*/
 
#ifndef _MAFSEQUENCE_H_
#define _MAFSEQUENCE_H_
 
#include "../../Feature/SequenceFeature.h"
 
#include <Bpp/Seq/SequenceWithAnnotation.h>
#include <Bpp/Seq/Alphabet/AlphabetTools.h>
#include <Bpp/Seq/SequenceTools.h>
 
namespace bpp {
 
class MafSequence:
  public SequenceWithAnnotation
{
  private:
    bool         hasCoordinates_;
    size_t       begin_;
    std::string  species_;
    std::string  chromosome_;
    char         strand_;
    size_t       size_;
    size_t       srcSize_;
 
  public:
    MafSequence(const Alphabet* alphabet = &AlphabetTools::DNA_ALPHABET):
      EdSymbolList<int>(alphabet),
      EdIntSymbolList(alphabet),
      SequenceWithAnnotation(alphabet), hasCoordinates_(false), begin_(0), species_(""), chromosome_(""), strand_(0), size_(0), srcSize_(0)
    {}
 
    MafSequence(const std::string& name, const std::string& sequence, bool parseName = true, const Alphabet* alphabet = &AlphabetTools::DNA_ALPHABET):
      EdSymbolList<int>(alphabet),
      EdIntSymbolList(alphabet),
      SequenceWithAnnotation(name, sequence, alphabet), hasCoordinates_(false), begin_(0), species_(""), chromosome_(""), strand_(0), size_(0), srcSize_(0)
    {
      size_ = SequenceTools::getNumberOfSites(*this);
      if (parseName)
        splitNameIntoSpeciesAndChromosome(name, species_, chromosome_);
    }
 
    MafSequence(const std::string& name, const std::string& sequence, size_t begin, char strand, size_t srcSize, bool parseName = true, const Alphabet* alphabet = &AlphabetTools::DNA_ALPHABET) :
      EdSymbolList<int>(alphabet),
      EdIntSymbolList(alphabet),
      SequenceWithAnnotation(name, sequence, alphabet), hasCoordinates_(true), begin_(begin), species_(""), chromosome_(""), strand_(strand), size_(0), srcSize_(srcSize)
    {
      size_ = SequenceTools::getNumberOfSites(*this);
      if (parseName)
        splitNameIntoSpeciesAndChromosome(name, species_, chromosome_);
    }
 
    MafSequence* clone() const { 
      return new MafSequence(*this);
    }
 
    MafSequence* cloneMeta() const { 
      return new MafSequence(getName(), std::string(), begin_, strand_, srcSize_, true);
    }
    
    ~MafSequence() {}
 
  public:
    bool hasCoordinates() const { return hasCoordinates_; }
 
    void removeCoordinates() { hasCoordinates_ = false; begin_ = 0; }
 
    size_t start() const {
      if (hasCoordinates_) return begin_;
      else throw Exception("MafSequence::start(). Sequence " + getName() + " does not have coordinates.");
    }
 
    size_t stop() const { 
      if (hasCoordinates_) return begin_ + size_;
      else throw Exception("MafSequence::stop(). Sequence " + getName() + " does not have coordinates.");
    }
 
    Range<size_t> getRange(bool origin = true) const {
      if (hasCoordinates_) {
        if (origin && strand_ == '-') {
          return Range<size_t>(srcSize_ - stop(), srcSize_ - start());
        } else {
          return Range<size_t>(start(), stop());
        }
      }
      else throw Exception("MafSequence::getRange(). Sequence " + getName() + " does not have coordinates.");
    }
 
    void setName(const std::string& name) {
      try {
        splitNameIntoSpeciesAndChromosome(name, species_, chromosome_);
      } catch (Exception& e) {
        species_ = "";
        chromosome_ = "";
      }
      SequenceWithAnnotation::setName(name);
    }
 
    static void splitNameIntoSpeciesAndChromosome(const std::string& name, std::string& species, std::string& chr) {
      size_t pos = name.find(".");
      if (pos != std::string::npos) {
        chr     = name.substr(pos + 1);
        species = name.substr(0, pos);
      } else {
        throw Exception("MafSequence::splitNameIntospeciesAndChromosome(). Invalid sequence name: " + name);
      }
    }
 
    const std::string& getSpecies() const { return species_; }
    
    const std::string& getChromosome() const { return chromosome_; }
    
    char getStrand() const { return strand_; }
    
    size_t getGenomicSize() const { return size_; }
    
    size_t getSrcSize() const { return srcSize_; }
    
    void setStart(size_t begin) { begin_ = begin; hasCoordinates_ = true; }
    
    void setChromosome(const std::string& chr) {
      chromosome_ = chr;
      SequenceWithAnnotation::setName(species_ + "." + chromosome_);
    }
    
    void setSpecies(const std::string& species) {
      species_ = species;
      SequenceWithAnnotation::setName(species_ + "." + chromosome_);
    }
    
    void setStrand(char s) { strand_ = s; }
    
    void setSrcSize(size_t srcSize) { srcSize_ = srcSize; }
  
    std::string getDescription() const { return getName() + strand_ + ":" + (hasCoordinates_ ? TextTools::toString(start()) + "-" + TextTools::toString(stop()) : "?-?"); }
  
    MafSequence* subSequence(size_t startAt, size_t length) const;
    
  private:
    void beforeSequenceChanged(const IntSymbolListEditionEvent& event) {}
    void afterSequenceChanged(const IntSymbolListEditionEvent& event) { size_ = SequenceTools::getNumberOfSites(*this); }
    void beforeSequenceInserted(const IntSymbolListInsertionEvent& event) {}
    void afterSequenceInserted(const IntSymbolListInsertionEvent& event) { size_ = SequenceTools::getNumberOfSites(*this); }
    void beforeSequenceDeleted(const IntSymbolListDeletionEvent& event) {}
    void afterSequenceDeleted(const IntSymbolListDeletionEvent& event) { size_ = SequenceTools::getNumberOfSites(*this); }
    void beforeSequenceSubstituted(const IntSymbolListSubstitutionEvent& event) {}
    void afterSequenceSubstituted(const IntSymbolListSubstitutionEvent& event) {}
};
 
} // end of namespace bpp.
 
#endif //_MAFSEQUENCE_H_